Cardiovascular and metabolic disease research at Novartis

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title="Novartis quality management system (QMS)" href="/about/quality/novartis-quality-management-system-qms" > <i class="borderH"></i> Novartis quality management system (QMS)  </a> </li> <li class="we-mega-menu-li" data-level="2" data-element-type="we-mega-menu-li" data-id="1c43d8d3-d2b2-46b0-bd57-e2b1fe5a0077" data-submenu="0" data-group="0" data-class="" data-icon="" data-caption="" data-alignsub="" data-target=""> <i class="borderH"></i> <a class="we-mega-menu-li" title="Product and patient safety training" href="/about/quality/product-and-patient-safety-training" > <i class="borderH"></i> Product and patient safety training  </a> </li> <li class="we-mega-menu-li" data-level="2" data-element-type="we-mega-menu-li" data-id="901cc6b8-10c6-49ee-83a1-a3316ea720c5" data-submenu="0" data-group="0" data-class="" data-icon="" data-caption="" data-alignsub="" data-target=""> <i class="borderH"></i> <a class="we-mega-menu-li" title="Regulatory inspections" 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data-level="1" data-element-type="we-mega-menu-li" data-id="23da37d2-b27b-4c8c-9b93-9b1bc88b131d" data-submenu="0" data-group="0" data-class="" data-icon="" data-caption="" data-alignsub="" data-target=""> <i class="borderH"></i> <a class="we-mega-menu-li" title="Awards and recognition" href="/about/awards-and-recognition" > <i class="borderH"></i> Awards and recognition  </a> </li> </ul> </div> <div class="we-mega-menu-col span6" data-element-type="we-mega-menu-col" data-width="6" data-block="polaris_aboutusmegamenu" data-blocktitle="0" data-hidewhencollapse="" data-class=""> <div class="type-of-block"><div class="block-inner"><div class="megamenu-content-block"> <div id="block-polaris-aboutusmegamenu" data-block-plugin-id="block_content:b3e5f886-7b1e-4657-9cdf-7edd29b61713" class="block-content-mega_menu"> <div class="section-image"> <img src="/sites/novartis_com/files/styles/image_mega_menu/public/2023-11/mother-daughter-cuddling-on-a-bed-kid-room-menu.jpg.webp?itok=KmIUz5U9" alt="Mother and daughter cuddling on a bed in a kids room" title="Mother and daughter cuddling on a bed in a kids room"/> </div> <div class="section-content"> <p>About</p> </div> <div class="section-description" > <p><span lang="EN-GB">Novartis is an innovative medicines company. Every day, we work to reimagine medicine to improve and extend people’s lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach more than 250 million people worldwide.</span><span lang="EN-GB"></span></p> </div> </div> </div> </div></div> </div> </div> </div> </div> </li> <li class="we-mega-menu-li dropdown-menu" data-level="0" data-element-type="we-mega-menu-li" data-id="46c98121-e544-4ac9-bc64-a92da86975ca" data-submenu="1" data-group="0" data-class="" data-icon="" data-caption="" data-alignsub="" data-target=""> <i class="borderH"></i> <a class="we-mega-menu-li" title="Patients and caregivers" href="/patients-and-caregivers" > <i class="borderH"></i> Patients and caregivers  </a> <div class="we-mega-menu-submenu" data-element-type="we-mega-menu-submenu"> <span class="more_from"></span> <div class="we-mega-menu-submenu-inner"> <div class="we-mega-menu-row" data-element-type="we-mega-menu-row" data-custom-row="1"> <div class="we-mega-menu-col span6" data-element-type="we-mega-menu-col" data-width="6" data-block="" data-blocktitle="0" data-hidewhencollapse="" data-class=""> <ul class="nav 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data-id="0617991d-c0cc-4cdf-a385-b0656846b215" data-submenu="0" data-group="0" data-class="" data-icon="" data-caption="" data-alignsub="" data-target=""> <i class="borderH"></i> <a class="we-mega-menu-li" title="Patient organization funding" href="/investors/reporting-and-transparency-hub/patient-organization-funding" > <i class="borderH"></i> Patient organization funding  </a> </li> <li class="we-mega-menu-li" data-level="1" data-element-type="we-mega-menu-li" data-id="a60978a2-5d32-4919-acce-3930fd343297" data-submenu="0" data-group="0" data-class="" data-icon="" data-caption="" data-alignsub="" data-target=""> <i class="borderH"></i> <a class="we-mega-menu-li" title="Patients perspectives stories" href="/news/stories/patient-perspectives" > <i class="borderH"></i> Patients perspectives stories  </a> </li> </ul> </div> <div class="we-mega-menu-col span6" data-element-type="we-mega-menu-col" data-width="6" data-block="polaris_pastprogramsmegamenu" data-blocktitle="0" data-hidewhencollapse="" data-class=""> <div class="type-of-block"><div class="block-inner"><div class="megamenu-content-block"> <div id="block-polaris-pastprogramsmegamenu" data-block-plugin-id="block_content:ed5e103c-408c-400f-b126-a637a4f8892b" class="block-content-mega_menu"> <div class="section-image"> <img src="/sites/novartis_com/files/styles/image_mega_menu/public/2023-11/daughter-talking-to-senior-parents-on-bench-in-park-menu.jpg.webp?itok=5-8i5oYL" alt="Adult daughter talking to her senior parents on a bench in a park" title="Adult daughter talking to her senior parents on a bench in a park"/> </div> <div class="section-content"> <p>Patients and caregivers</p> </div> <div class="section-description"> <p>Information for patients and their caregivers including clinical trial recruiting, managed access programs, funding opportunities for patient organizations and side effects reporting.</p> </div> </div> </div> </div></div> </div> </div> </div> </div> </li> <li 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Explore the Novartis in Society Integrated Report.</p> </div> </div> </div> </div></div> </div> </div> </div> </div> </li> <li class="we-mega-menu-li dropdown-menu" data-level="0" data-element-type="we-mega-menu-li" data-id="201d99e2-cf92-4d8f-adb4-ba5c192edb83" data-submenu="1" data-group="0" data-class="" data-icon="" data-caption="" data-alignsub="" data-target=""> <i class="borderH"></i> <a class="we-mega-menu-li" title="Investors" href="/investors" > <i class="borderH"></i> Investors  </a> <div class="we-mega-menu-submenu" data-element-type="we-mega-menu-submenu"> <span class="more_from"></span> <div class="we-mega-menu-submenu-inner"> <div class="we-mega-menu-row" data-element-type="we-mega-menu-row" data-custom-row="1"> <div class="we-mega-menu-col span6" data-element-type="we-mega-menu-col" data-width="6" data-block="" data-blocktitle="0" data-hidewhencollapse="" data-class=""> <ul class="nav nav-tabs subul"> <li class="we-mega-menu-li" data-level="1" 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href="https://www.novartis.com/research-and-development/research-disease-areas/cardiovascular-and-metabolic-disease-research-novartis">Cardiovascular and metabolic disease research at Novartis</a> </li> </ol> </nav> </div> </div> </div> <div class="container"> <div class="page_title "> <section class="row region region-page-title"> <div id="block-polaris-page-title" data-block-plugin-id="page_title_block" class="block block-core block-page-title-block"> <div class="content"> <h1 class="title"><span class="field field--name-title field--type-string field--label-hidden">Cardiovascular and metabolic disease research at Novartis</span> </h1> </div> </div> </section> </div> </div> <div id="main" class="container-fluid custom_width"> <div class="row row-offcanvas row-offcanvas-left clearfix"> <div class="container"> <div class="main-content col order-last col-md-8 col-sm-12 content_left_side column-three-fourth float-start" id="content"> <section class="section"> <div id="block-polaris-content" data-block-plugin-id="system_main_block" class="block block-system block-system-main-block"> <div class="content"> <div about="/research-and-development/research-disease-areas/cardiovascular-and-metabolic-disease-research-novartis" class="node node--type-interior-page node--view-mode-full clearfix"> <header> </header> <div class="node__content clearfix"> <div class="page_content"> <div class="row content_middle"> <div class="col-sm-12 content_left_side"> <div class="field_body_txt "> <div class="field field--name-field-body field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--rich-text-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-with-summary field--label-hidden field__item"><p><em>With new tools and approaches comes broader opportunity to benefit patients.</em></p> <p>Cardiovascular and metabolic diseases are responsible for nearly 18 million deaths worldwide each year and represent a huge burden for individuals and society.</p> <p>Our cardiovascular and metabolic disease researchers are developing a diverse portfolio of approaches to prevent, slow, or reverse these conditions.</p> <figure role="group" class="caption caption-drupal-media"> <div> <div class="field field--name-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/novartis_com/files/styles/crop_freeform/public/2021-10/cardiomyocytes-cvm-hero.jpg.webp?itok=jnSP36Tj" width="800" height="450" alt="Heart muscle cells." title="Cardiomyocytes." typeof="foaf:Image" class="image-style-crop-freeform"> </div> </div> <figcaption>Super-resolution microscopy of cardiomyocytes. Credit Frederique Black.</figcaption> </figure> <p>Led by <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="8a14d343-c6c1-406b-b25d-16eb6faa6043" href="/stories/exploring-longstanding-questions-about-heart-disease" title="Exploring longstanding questions about heart disease">Shaun Coughlin</a>, the team uses every tool at its disposal to better understand the root causes of cardiovascular and metabolic diseases, discover and develop drugs against relevant targets, and better identify patients by prognosis and mechanism to provide them with maximum benefit at minimum risk.</p> <p>Our priorities include:</p> <ul> <li><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="e6a1cad2-07db-4565-89ee-d3c6b40c0bba" href="/stories/need-new-heart-disease-medicines-drives-wave-potential-therapies" title="Need for new heart disease medicines drives wave of potential therapies">Atherosclerosis</a>: Atherosclerosis causes most heart attacks, strokes and peripheral arterial disease and remains the single leading cause of morbidity and premature mortality. Our portfolio and pipeline focus on therapies to reduce low-density lipoprotein (LDL) cholesterol and decrease inflammation, key drivers of the formation of plaques in the arteries. Strategies to reverse atherosclerosis are also under exploration.</li> <li><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="e614c449-8f3e-4a5f-80c6-89f6538ca25a" href="/stories/living-hfpef-patients-story" title="Living with HFpEF – a patient’s story">Heart failure</a>: Heart failure with preserved ejection fraction is an increasingly prevalent disorder in which the pumping chamber becomes stiff and unable to function normally. We seek to understand the mechanisms driving this form of heart failure and develop novel therapies. We continue to develop next generation therapies to treat or prevent heart failure with reduced ejection fraction.</li> <li><strong>Atrial fibrillation</strong>: We seek to develop safer antiarrhythmic drugs to maintain normal sinus rhythm and to understand the root cause of atrial fibrillation to ultimately prevent it.</li> <li><strong>Obesity-driven disease</strong>: Obesity is epidemic and drives type-2 diabetes, cardiovascular risk, and a host of other diseases. We seek therapies that can deliver substantial and durable weight loss to reverse and prevent obesity-driven diseases.</li> </ul> <p>"Cardiovascular and metabolic diseases remain a major cause of morbidity and mortality and Novartis is committed to addressing this unmet need," says Coughlin. "With the tremendous tools and technologies available, there is a great opportunity to change medicine and impact public health.”</p></div> </div> </div> <div class="field__item"> <div class="cta-teaser"> <h3 class="cta_title " > Reimagine medicine with Novartis </h3> <div class="cta_description"></div> <a class="link_button button_text" href="/careers/career-search?search_api_fulltext=Cardio&items_per_page=10&job_division%5B0%5D=DIV_RE&field_job_posted_date=All" target="_self" title="Learn about opportunities to join our team" >Learn about opportunities to join our team</a> </div> </div> </div> </div> </div> </div> <div class="content_bottom"> <div class="field field--name-field-protected field--type-nc-content-protection-code field--label-hidden field__item"></div> </div> </div> </div> </div> </div> </div> </section> </div> <div class="sidebar_second sidebar col-md-3 offset-md-1 col-sm-12 content_right_side float-end" id="sidebar_second"> <div class="section second-sidebar"> <div 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