Targeted Protein Degradation and Induced Proximity Product Guide

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The PROTAC Degraders approach employs small molecules, which simultaneously bind to the target protein of interest and an E3 ligase to form a ternary complex. This initiates the ubiquitination of the target protein and its subsequent destruction by the proteasome. Using this technology, efficient and highly selective protein knock-down can be achieved both in vitro and in vivo.This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research:Tools for target validation and exploration, including a wide range of active Degraders and the TAG Degradation Platform (dTAG, aTAG and BromoTag\u00ae)Products and services to facilitate design and synthesis of your own Degraders, including Degrader Building Blocks and our online PROTAC\u00ae Panel Builder toolAssays for Degrader development and analysis of downstream effects (including TR-FRET/FP and Simple WesternTM , automated western blotting instruments to monitor degradation of protein)Protein Degraders, validated antibodies and reagentsTools for Induced Proximity research.Learn more about how Bio-Techne supports your Targeted Protein Degradation Research.PROTAC\u00ae is a registered trademark of Arvinas Operations, Inc., and is used under license.BromoTag\u00ae is a registered trademark of the University of Dundee and is used under license.","image":"https://resources.bio-techne.com/bio-techne-assets/images/literature/bio-techne-tpd-brochure-thumb.jpg","author":{"@type":"Organization","name":"Bio-techne","url":"https://www.bio-techne.com/"},"publisher":{"logo":{"url":"https://resources.bio-techne.com/bio-techne-assets/images/brands/bio-techne-og.png"}},"datePublished":"2022-11-04T08:12:27-05:00","dateModified":"2024-10-07T10:55:52-05:00"}</script> <meta http-equiv="x-ua-compatible" content="ie=edge" /> <link rel="alternate" hreflang="en" href="https://www.bio-techne.com/resources/literature/targeted-protein-degradation-research-guide" /> <link rel="alternate" hreflang="zh-hans" href="https://www.bio-techne.com/cn/node/6786" /> <link rel="icon" href="/themes/custom/bio_techne_global/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="preconnect" href="https://resources.bio-techne.com" /> 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href="/resources/literature?tid%5B411%5D=411" class="badge-pill badge-primary font-weight-bold bg-white a___border-bt-blue bg-white text-bt-blue d-inline-block mb-3"> Product Guides and Listings </a> </div> </div> <div class="card p-4"> <div class="row"> <div class="col-md-6"> <h3>Product Guides and Listings Summary</h3> <div class="d-flex justify-content-center"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/literature/bio-techne-tpd-brochure-thumb.jpg" alt="TPD Brochure FrontImg" loading="lazy" > </div> <div> <div><h2>Supporting Targeted Protein Degradation Research</h2><p>Targeted Protein Degradation (TPD) is a simple and versatile method to knock-down a target protein of interest using small molecules (including PROTAC<sup>®</sup> Degraders, SNIPERS, molecular glues etc.) and is an area of increasing research interest. The PROTAC Degraders approach employs small molecules, which simultaneously bind to the target protein of interest and an E3 ligase to form a ternary complex. This initiates the ubiquitination of the target protein and its subsequent destruction by the proteasome. Using this technology, efficient and highly selective protein knock-down can be achieved both <em>in vitro</em> and <em>in vivo</em>.</p><p>This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research:</p><ul><li>Tools for target validation and exploration, including a wide range of active Degraders and the TAG Degradation Platform (dTAG, aTAG and BromoTag<sup>®</sup>)</li><li>Products and services to facilitate design and synthesis of your own Degraders, including Degrader Building Blocks and our online PROTAC<sup>®</sup> Panel Builder tool</li><li>Assays for Degrader development and analysis of downstream effects (including TR-FRET/FP and Simple Western<sup>TM </sup>, automated western blotting instruments to monitor degradation of protein)</li><li>Protein Degraders, validated antibodies and reagents</li><li>Tools for Induced Proximity research.</li></ul><p>Learn more about how Bio-Techne supports your <a href="/research-areas/targeted-protein-degradation">Targeted Protein Degradation Research</a>.</p><p><em>PROTAC<sup>®</sup> is a registered trademark of Arvinas Operations, Inc., and is used under license</em>.</p><p><em>BromoTag<sup>®</sup> is a registered trademark of the University of Dundee and is used under license.</em></p></div> </div> </div> <div class="col-md-6" id="marketo-component-div" data-literaturedetails="{"formId":"7172","documentID":"<a href=\"https:\/\/www.bio-techne.com\/resources\/literature\/targeted-protein-degradation-research-guide\">https:\/\/www.bio-techne.com\/resources\/literature\/targeted-protein-degrad\u2026<\/a>","documentName":"Targeted Protein Degradation and Induced Proximity","documentproducts":"NULL","documentType":"Brochures and Datasheets"}"> <h3>Request Literature</h3> <p>To access this literature content please fill out the form below. </p> <div> <div id="block-bio-techne-global-content" class="paragraph"> <article> <div 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