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<span>Gene structure</span> </div> </a> <ul id="toc-Gene_structure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Tissue-specific_expression" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Tissue-specific_expression"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Tissue-specific expression</span> </div> </a> <ul id="toc-Tissue-specific_expression-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Protein_structure" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Protein_structure"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Protein structure</span> </div> </a> <ul id="toc-Protein_structure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Associated_diseases" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Associated_diseases"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Associated diseases</span> </div> </a> <button aria-controls="toc-Associated_diseases-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Associated diseases subsection</span> </button> <ul id="toc-Associated_diseases-sublist" class="vector-toc-list"> <li id="toc-Multi-system_form_of_type_I_pseudohypoaldosteronism_(PHA1B)" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Multi-system_form_of_type_I_pseudohypoaldosteronism_(PHA1B)"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>Multi-system form of type I pseudohypoaldosteronism (PHA1B)</span> </div> </a> <ul id="toc-Multi-system_form_of_type_I_pseudohypoaldosteronism_(PHA1B)-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Liddle_syndrome" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Liddle_syndrome"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>Liddle syndrome</span> </div> </a> <ul id="toc-Liddle_syndrome-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Interactions" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Interactions</span> </div> </a> <ul id="toc-Interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Notes" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Notes"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Notes</span> </div> </a> <ul id="toc-Notes-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 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id="mw-indicator-Journal_Icon.svg" class="mw-indicator"><div class="mw-parser-output"><span typeof="mw:File"><a href="https://doi.org/10.1016/J.GENE.2015.12.061" title="This article was updated by an external expert under a dual publication model. The corresponding peer-reviewed article was published in the journal Gene. Click to view." rel="nofollow"><img alt="This article was updated by an external expert under a dual publication model. The corresponding peer-reviewed article was published in the journal Gene. Click to view." src="//upload.wikimedia.org/wikipedia/commons/thumb/6/63/Journal_Icon.svg/20px-Journal_Icon.svg.png" decoding="async" width="20" height="18" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/63/Journal_Icon.svg/30px-Journal_Icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/63/Journal_Icon.svg/40px-Journal_Icon.svg.png 2x" data-file-width="525" data-file-height="479" /></a></span></div></div> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">SCNN1G</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/10602">SCNN1G</a></span>, BESC3, ENaCg, ENaCgamma, PHA1, SCNEG, sodium channel epithelial 1 gamma subunit, LDLS2, sodium channel epithelial 1 subunit gamma</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/600761">600761</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:104695">104695</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=20280">20280</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=SCNN1G">SCNN1G</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000166828">SCNN1G - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_16.svg" class="mw-file-description" title="Chromosome 16 (human)"><img alt="Chromosome 16 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/300px-Ideogram_human_chromosome_16.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/450px-Ideogram_human_chromosome_16.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/600px-Ideogram_human_chromosome_16.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_16_(human)" class="mw-redirect" title="Chromosome 16 (human)">Chromosome 16 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_16_ideogram.svg" class="mw-file-description" title="Chromosome 16 (human)"><img alt="Chromosome 16 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Human_chromosome_16_ideogram.svg/300px-Human_chromosome_16_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Human_chromosome_16_ideogram.svg/450px-Human_chromosome_16_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Human_chromosome_16_ideogram.svg/600px-Human_chromosome_16_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 70.136423998301px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for SCNN1G"><img alt="Genomic location for SCNN1G" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 76.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for SCNN1G"><img alt="Genomic location for SCNN1G" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">16p12.2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">23,182,745 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">23,216,883 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_7.svg" class="mw-file-description" title="Chromosome 7 (mouse)"><img alt="Chromosome 7 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/390px-Ideogram_house_mouse_chromosome_7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/520px-Ideogram_house_mouse_chromosome_7.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 7 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_7.svg" class="mw-file-description" title="Chromosome 7 (mouse)"><img alt="Chromosome 7 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/300px-Ideogram_of_house_mouse_chromosome_7.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/450px-Ideogram_of_house_mouse_chromosome_7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/600px-Ideogram_of_house_mouse_chromosome_7.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 240.01330896055px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for SCNN1G"><img alt="Genomic location for SCNN1G" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 246px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for SCNN1G"><img alt="Genomic location for SCNN1G" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">7 F2|7 65.07 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">121,333,702 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">121,367,698 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000166828">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">renal medulla</li><br /><li style="line-height: 137%;">bronchial epithelial cell</li><br /><li style="line-height: 137%;">human kidney</li><br /><li style="line-height: 137%;">mucosa of paranasal sinus</li><br /><li style="line-height: 137%;">lower lobe of lung</li><br /><li style="line-height: 137%;">salivary gland</li><br /><li style="line-height: 137%;">minor salivary glands</li><br /><li style="line-height: 137%;">parotid gland</li><br /><li style="line-height: 137%;">skin of leg</li><br /><li style="line-height: 137%;">upper lobe of lung</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000000216">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right lung lobe</li><br /><li style="line-height: 137%;">left lung</li><br /><li style="line-height: 137%;">transitional epithelium of urinary bladder</li><br /><li style="line-height: 137%;">vestibular membrane of cochlear duct</li><br /><li style="line-height: 137%;">left lung lobe</li><br /><li style="line-height: 137%;">right kidney</li><br /><li style="line-height: 137%;">medullary collecting duct</li><br /><li style="line-height: 137%;">renal pelvis</li><br /><li style="line-height: 137%;">connecting tubule</li><br /><li style="line-height: 137%;">human kidney</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000166828">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005272">sodium channel activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005216">ion channel activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050699">WW domain binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015280">ligand-gated sodium channel activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034706">sodium channel complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016324">apical plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070062">extracellular exosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009897">external side of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007588">excretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035725">sodium ion transmembrane transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050896">response to stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006814">sodium ion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006811">ion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0055078">sodium ion homeostasis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050891">multicellular organismal water homeostasis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050909">sensory perception of taste</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034220">ion transmembrane transport</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=6340&rn=1">6340</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=20278&rn=1">20278</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000166828;db=core">ENSG00000166828</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000000216;db=core">ENSMUSG00000000216</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P51170">P51170</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9WU39">Q9WU39</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001039">NM_001039</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_011326">NM_011326</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001030">NP_001030</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_035456">NP_035456</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr16:23182745-23216883">Chr 16: 23.18 – 23.22 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr7:121333702-121367698">Chr 7: 121.33 – 121.37 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18031405" class="extiw" title="d:Q18031405">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18253957" class="extiw" title="d:Q18253957">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p>The <i><b>SCNN1G</b></i> gene encodes for the γ subunit of the epithelial sodium channel <a href="/wiki/ENaC" class="mw-redirect" title="ENaC">ENaC</a> in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by <i><a href="/wiki/SCNN1A" title="SCNN1A">SCNN1A</a></i>, <i><a href="/wiki/SCNN1B" title="SCNN1B">SCNN1B</a></i>, and <i><a href="/wiki/SCNN1D" title="SCNN1D">SCNN1D</a></i>.<sup id="cite_ref-2016-Hanukoglu_5-0" class="reference"><a href="#cite_note-2016-Hanukoglu-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>ENaC is expressed in epithelial cells and is different from the voltage-gated sodium channel that is involved in the generation of action potentials in neurons. The abbreviation for the genes encoding for voltage-gated sodium channel starts with three letters: SCN. In contrast to these sodium channels, ENaC is constitutively active and is not voltage-dependent. The second N in the abbreviation (SCNN1) represents that these are NON-voltage-gated channels. </p><p>In most vertebrates, sodium ions are the major determinant of the osmolarity of the extracellular fluid.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> ENaC allows transfer of sodium ions across the epithelial cell membrane in so-called "tight-epithelia" that have low permeability. The flow of sodium ions across epithelia affects osmolarity of the extracellular fluid. Thus, ENaC plays a central role in the regulation of body fluid and electrolyte homeostasis and consequently affects blood pressure.<sup id="cite_ref-2015-Rossier_7-0" class="reference"><a href="#cite_note-2015-Rossier-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>As ENaC is strongly inhibited by <a href="/wiki/Amiloride" title="Amiloride">amiloride</a>, it is also referred to as an "amiloride-sensitive sodium channel". </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=1" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The first cDNA encoding the gamma subunit of ENaC was cloned and sequenced by Canessa et al. from rat mRNA.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> A year later, two independent groups reported the cDNA sequences of the beta- and gamma-subunits of the human ENaC.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-1995-Voilley_10-0" class="reference"><a href="#cite_note-1995-Voilley-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The complete coding sequence human γ subunit was reported by Saxena et al.<sup id="cite_ref-2002-Saxena_11-0" class="reference"><a href="#cite_note-2002-Saxena-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Gene_structure">Gene structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=2" title="Edit section: Gene structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>While the human gene <a href="/wiki/SCNN1A" title="SCNN1A">SCNN1A</a> is located in chromosome 12p,<sup id="cite_ref-1998-Ludwig_12-0" class="reference"><a href="#cite_note-1998-Ludwig-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> the human genes encoding SCNN1B and SCNN1G are located in juxtoposition in the short arm of chromosome 16 (16p12-p13).<sup id="cite_ref-1995-Voilley_10-1" class="reference"><a href="#cite_note-1995-Voilley-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The structures of the human and rat SCNN1G genes were first reported by Thomas et al.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Later studies by Saxena et al. reported the complete coding sequence of the human SCNN1G gene establishing that it has 13 exons <sup id="cite_ref-2002-Saxena_11-1" class="reference"><a href="#cite_note-2002-Saxena-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> The positions of introns are conserved in all three human ENaC genes, SCNN1A, SCNN1B and SCNN1G.<sup id="cite_ref-1998-Saxena_15-0" class="reference"><a href="#cite_note-1998-Saxena-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> The positions of the introns are also highly conserved across vertebrates See: <a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/Gene/Compara_Tree?db=core;g=ENSG00000168447;r=16:23278231-23381299">Ensembl GeneTree</a>. </p> <figure class="mw-halign-left" typeof="mw:File/Frame"><a href="http://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000166828;r=16:23182715-23216883;t=ENST00000300061" rel="nofollow"><img src="//upload.wikimedia.org/wikipedia/commons/8/8b/SCNN1G-gene-transcript-Hanukoglu.png" decoding="async" width="956" height="202" class="mw-file-element" data-file-width="956" data-file-height="202" /></a><figcaption>Fig. 1. Exon-intron structure of the major transcript of the human SCNN1B. The number of each exon is marked above the exon. The serial number of the transcript is shown above the transcript. Clicking on the figure will direct the reader to the list of transcripts in the Ensembl database.</figcaption></figure> <div style="clear:both;" class=""></div> <div class="mw-heading mw-heading2"><h2 id="Tissue-specific_expression">Tissue-specific expression</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=3" title="Edit section: Tissue-specific expression"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The three ENaC subunits encoded by <a href="/wiki/SCNN1A" title="SCNN1A">SCNN1A</a>, SCNN1B, and SCNN1G are commonly expressed in tight epithelia that have low water permeability. The major organs where ENaC is expressed include parts of the kidney tubular epithelia,<sup id="cite_ref-2016-Hanukoglu_5-1" class="reference"><a href="#cite_note-2016-Hanukoglu-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-2015-Rossier_7-1" class="reference"><a href="#cite_note-2015-Rossier-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-1994-Duc_16-0" class="reference"><a href="#cite_note-1994-Duc-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> the respiratory airway,<sup id="cite_ref-2012-Enuka_17-0" class="reference"><a href="#cite_note-2012-Enuka-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> the female reproductive tract,<sup id="cite_ref-2012-Enuka_17-1" class="reference"><a href="#cite_note-2012-Enuka-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> colon, salivary and sweat glands.<sup id="cite_ref-1994-Duc_16-1" class="reference"><a href="#cite_note-1994-Duc-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p><p>ENaC is also expressed in the tongue, where it has been shown to be essential for the perception of salt taste.<sup id="cite_ref-1994-Duc_16-2" class="reference"><a href="#cite_note-1994-Duc-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p><p>The expression of ENaC subunit genes is regulated mainly by the mineralocorticoid hormone aldosterone that is activated by the renin-angiotensin system.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Protein_structure">Protein structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=4" title="Edit section: Protein structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The primary structures of all four ENaC subunits show strong similarity. Thus, these four proteins represent a family of proteins that share a common ancestor. In global alignment (meaning alignments of sequences along their entire length and not just a partial segment), the human γ subunit shares 34% identity with the β subunit and 27 and 23% identity with the α and δ subunits. </p><p>All four ENaC subunit sequences have two hydrophobic stretches that form two transmembrane segments named as TM1 and TM2.<sup id="cite_ref-2016-Hanukoglu_5-2" class="reference"><a href="#cite_note-2016-Hanukoglu-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> In the membrane-bound form, the TM segments are embedded in the membrane bilayer, the amino- and carboxy-terminal regions are located inside the cell, and the segment between the two TMs remains outside of the cell as the extracellular region of ENaC. This extracellular region includes about 70% of the residues of each subunit. Thus, in the membrane-bound form, the bulk of each subunit is located outside of the cell.<sup id="cite_ref-2016-Hanukoglu_5-3" class="reference"><a href="#cite_note-2016-Hanukoglu-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>The structure of ENaC has not been yet determined. Yet, the structure of a homologous protein ASIC1 has been resolved.<sup id="cite_ref-2007-Jasti_21-0" class="reference"><a href="#cite_note-2007-Jasti-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> The chicken ASIC1 structure revealed that ASIC1 is assembled as a homotrimer of three identical subunits. The authors of the original study suggested that the ASIC1 trimer resembles a hand holding a ball.<sup id="cite_ref-2007-Jasti_21-1" class="reference"><a href="#cite_note-2007-Jasti-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> Hence distinct domains of ASIC1 have been referred to as palm, knuckle, finger, thumb, and β-ball.<sup id="cite_ref-2007-Jasti_21-2" class="reference"><a href="#cite_note-2007-Jasti-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p><p>Site-directed mutagenesis of the human γ subunit suggests that ENaC subunits have a structure similar to that of ASIC1.<sup id="cite_ref-2014-Edelheit_23-0" class="reference"><a href="#cite_note-2014-Edelheit-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> The ion selectivity filter of ENaC has been modeled based on the ASIC1 structure.<sup id="cite_ref-2016-Hanukoglu-b_24-0" class="reference"><a href="#cite_note-2016-Hanukoglu-b-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p><p>Alignment of ENaC subunit sequences with ASIC1 sequence reveals that TM1 and TM2 segments and palm domain are conserved, and the knuckle, finger and thumb domains have insertions in ENaC. Site-directed mutagenesis studies on ENaC subunits provide evidence that many basic features of the ASIC1 structural model apply to ENaC as well.<sup id="cite_ref-2016-Hanukoglu_5-4" class="reference"><a href="#cite_note-2016-Hanukoglu-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>In the carboxy terminus of three ENaC subunits, (α, β and γ) there is a special conserved consensus sequence PPPXYXXL that is called the PY motif. This sequence is recognized by the so-called WW domains in a special E3 ubiquitin-protein ligase named Nedd4-2.<sup id="cite_ref-2011-Rotin_25-0" class="reference"><a href="#cite_note-2011-Rotin-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> Nedd4-2 ligates <a href="/wiki/Ubiquitin" title="Ubiquitin">ubiquitin</a> to the C-terminus of the ENaC subunit which marks the protein for degradation.<sup id="cite_ref-2011-Rotin_25-1" class="reference"><a href="#cite_note-2011-Rotin-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Associated_diseases">Associated diseases</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=5" title="Edit section: Associated diseases"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>At present, three major hereditary disorders are known to be associated with mutations in the SCNN1G gene. These are: 1. Multisystem pseudohypoaldosteronism, 2. Liddle syndrome, and 3. Cystic fibrosis-like disease.<sup id="cite_ref-2016-Hanukoglu_5-5" class="reference"><a href="#cite_note-2016-Hanukoglu-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Multi-system_form_of_type_I_pseudohypoaldosteronism_(PHA1B)"><span id="Multi-system_form_of_type_I_pseudohypoaldosteronism_.28PHA1B.29"></span>Multi-system form of type I pseudohypoaldosteronism (PHA1B)</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=6" title="Edit section: Multi-system form of type I pseudohypoaldosteronism (PHA1B)"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The disease most commonly associated with mutations in SCNN1B is the multi-system form of type I pseudohypoaldosteronism (PHA1B) that was first characterized by A. Hanukoglu as an autosomal recessive disease.<sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> This is a syndrome of unresponsiveness to aldosterone in patients that have high serum levels of aldosterone but suffer from symptoms of aldosterone deficiency with a high risk of mortality due to severe salt loss. Initially, this disease was thought to be a result of a mutation in the mineralocorticoid receptor (NR3C2) that binds aldosterone. But homozygosity mapping in 11 affected families revealed that the disease is associated with two loci on chromosome 12p13.1-pter and chromosome 16p12.2-13 that include the genes for SCNN1A and SCNN1B and SCNN1G respectively.<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> Sequencing of the ENaC genes identified mutation in affected patients, and functional expression of the mutated cDNAs further confirmed that identified mutations lead to the loss of activity of ENaC.<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> </p><p>In the majority of the patients with multi-system PHA1B a homozygous mutation or two compound heterozygous mutations have been detected.<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Liddle_syndrome">Liddle syndrome</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=7" title="Edit section: Liddle syndrome"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Liddle syndrome is generally caused by mutations in the PY motif or truncation of the C-terminus including loss of the PY motif in the β or γ ENaC subunits.<sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-35" class="reference"><a href="#cite_note-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-37" class="reference"><a href="#cite_note-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> Even though there is a PY motif also in the α subunit, so far Liddle disease has not observed in association with a mutation in the α subunit. Liddle syndrome is inherited as an autosomal dominant disease with a phenotype that includes early onset hypertension, metabolic alkalosis and low levels of plasma renin activity and mineralocorticoid hormone aldosterone. In the absence of a recognizable PY motif, ubiquitin-protein ligase Nedd4-2 cannot bind to the ENaC subunit and hence cannot attach a ubiquitin to it. Consequently, proteolysis of ENaC by proteasome is inhibited and ENaC accumulates in the membrane leading to enhanced activity of ENaC that causes hypertension.<sup id="cite_ref-38" class="reference"><a href="#cite_note-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-39" class="reference"><a href="#cite_note-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-40" class="reference"><a href="#cite_note-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-41" class="reference"><a href="#cite_note-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=8" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SCNN1G has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <ul><li><a href="/wiki/NEDD4" title="NEDD4">NEDD4</a>,<sup id="cite_ref-pmid10642508_42-0" class="reference"><a href="#cite_note-pmid10642508-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12167593_43-0" class="reference"><a href="#cite_note-pmid12167593-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11244092_44-0" class="reference"><a href="#cite_note-pmid11244092-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/STX1A" title="STX1A">STX1A</a>,<sup id="cite_ref-pmid14996668_45-0" class="reference"><a href="#cite_note-pmid14996668-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/Ubiquitin_C" title="Ubiquitin C">Ubiquitin C</a><sup id="cite_ref-pmid18632802_46-0" class="reference"><a href="#cite_note-pmid18632802-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid18322022_47-0" class="reference"><a href="#cite_note-pmid18322022-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=9" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Epithelial_sodium_channel" title="Epithelial sodium channel">Epithelial sodium channel</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Notes">Notes</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=10" title="Edit section: Notes"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1251242444">.mw-parser-output .ambox{border:1px solid #a2a9b1;border-left:10px solid #36c;background-color:#fbfbfb;box-sizing:border-box}.mw-parser-output .ambox+link+.ambox,.mw-parser-output .ambox+link+style+.ambox,.mw-parser-output .ambox+link+link+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+style+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+link+.ambox{margin-top:-1px}html body.mediawiki .mw-parser-output .ambox.mbox-small-left{margin:4px 1em 4px 0;overflow:hidden;width:238px;border-collapse:collapse;font-size:88%;line-height:1.25em}.mw-parser-output .ambox-speedy{border-left:10px solid #b32424;background-color:#fee7e6}.mw-parser-output .ambox-delete{border-left:10px solid #b32424}.mw-parser-output .ambox-content{border-left:10px solid #f28500}.mw-parser-output .ambox-style{border-left:10px solid #fc3}.mw-parser-output .ambox-move{border-left:10px solid #9932cc}.mw-parser-output .ambox-protection{border-left:10px solid #a2a9b1}.mw-parser-output .ambox .mbox-text{border:none;padding:0.25em 0.5em;width:100%}.mw-parser-output .ambox .mbox-image{border:none;padding:2px 0 2px 0.5em;text-align:center}.mw-parser-output .ambox .mbox-imageright{border:none;padding:2px 0.5em 2px 0;text-align:center}.mw-parser-output .ambox .mbox-empty-cell{border:none;padding:0;width:1px}.mw-parser-output .ambox .mbox-image-div{width:52px}@media(min-width:720px){.mw-parser-output .ambox{margin:0 10%}}@media print{body.ns-0 .mw-parser-output .ambox{display:none!important}}</style><table class="plainlinks metadata ambox ambox-notice" role="presentation" style="margin: 0 10%; border: 1px solid #aaa; border-left: 10px solid #1e90ff; background: #fbfbfb;"><tbody><tr><td class="mbox-image"><div class="mbox-image-div"><span typeof="mw:File"><a href="http://www.example.com" title="Journal" rel="nofollow"><img alt="Journal" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/63/Journal_Icon.svg/48px-Journal_Icon.svg.png" decoding="async" width="48" height="44" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/63/Journal_Icon.svg/72px-Journal_Icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/63/Journal_Icon.svg/96px-Journal_Icon.svg.png 2x" data-file-width="525" data-file-height="479" /></a></span></div></td><td class="mbox-text"><div class="mbox-text-span">The 2016 version of this article was updated by an external expert under a dual publication model. The corresponding <a href="/wiki/Scholarly_peer_review" title="Scholarly peer review">academic peer reviewed</a> article was published in <i><b>Gene </b></i> and can be cited as:<br /><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation journal cs1"><a href="/wiki/Israel_Hanukoglu" title="Israel Hanukoglu">Israel Hanukoglu</a>; Aaron Hanukoglu (1 April 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756657">"Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases"</a>. <i><a href="/wiki/Gene_(journal)" title="Gene (journal)">Gene</a></i>. Gene Wiki Review Series. <b>579</b> (2): 95–132. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FJ.GENE.2015.12.061">10.1016/J.GENE.2015.12.061</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0378-1119">0378-1119</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756657">4756657</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26772908">26772908</a>. <a href="/wiki/WDQ_(identifier)" class="mw-redirect" title="WDQ (identifier)">Wikidata</a> <a href="https://www.wikidata.org/wiki/Q28272095" class="extiw" title="d:Q28272095">Q28272095</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Epithelial+sodium+channel+%28ENaC%29+family%3A+Phylogeny%2C+structure-function%2C+tissue+distribution%2C+and+associated+inherited+diseases&rft.volume=579&rft.issue=2&rft.pages=95-132&rft.date=2016-04-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4756657%23id-name%3DPMC&rft.issn=0378-1119&rft_id=info%3Apmid%2F26772908&rft_id=info%3Adoi%2F10.1016%2FJ.GENE.2015.12.061&rft.au=Israel+Hanukoglu&rft.au=Aaron+Hanukoglu&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4756657&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASCNN1G" class="Z3988"></span></div></td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=11" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 33em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000166828">GRCh38: Ensembl release 89: ENSG00000166828</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000000216">GRCm38: Ensembl release 89: ENSMUSG00000000216</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=6340">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D6340&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASCNN1G" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=20278">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D20278&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASCNN1G" class="Z3988"></span></span> </li> <li id="cite_note-2016-Hanukoglu-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-2016-Hanukoglu_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-2016-Hanukoglu_5-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-2016-Hanukoglu_5-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-2016-Hanukoglu_5-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-2016-Hanukoglu_5-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-2016-Hanukoglu_5-5"><sup><i><b>f</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHanukogluHanukoglu2016" class="citation journal cs1">Hanukoglu I, Hanukoglu A (Jan 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756657">"Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases"</a>. <i>Gene</i>. <b>579</b> (2): 95–132. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.gene.2015.12.061">10.1016/j.gene.2015.12.061</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756657">4756657</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26772908">26772908</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Epithelial+sodium+channel+%28ENaC%29+family%3A+Phylogeny%2C+structure-function%2C+tissue+distribution%2C+and+associated+inherited+diseases.&rft.volume=579&rft.issue=2&rft.pages=95-132&rft.date=2016-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4756657%23id-name%3DPMC&rft_id=info%3Apmid%2F26772908&rft_id=info%3Adoi%2F10.1016%2Fj.gene.2015.12.061&rft.aulast=Hanukoglu&rft.aufirst=I&rft.au=Hanukoglu%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4756657&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASCNN1G" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBourque2008" class="citation journal cs1">Bourque CW (Jul 2008). 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Am.+J.+Physiol.+Renal+Physiol.&rft.atitle=Nedd4-2+isoforms+ubiquitinate+individual+epithelial+sodium+channel+subunits+and+reduce+surface+expression+and+function+of+the+epithelial+sodium+channel&rft.volume=294&rft.issue=5&rft.pages=F1157-65&rft.date=2008-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2424110%23id-name%3DPMC&rft_id=info%3Apmid%2F18322022&rft_id=info%3Adoi%2F10.1152%2Fajprenal.00339.2007&rft.aulast=Raikwar&rft.aufirst=NS&rft.au=Thomas%2C+CP&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2424110&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASCNN1G" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=12" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 33em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStaubGautschiIshikawaBreitschopf1998" class="citation journal cs1">Staub O, Gautschi I, Ishikawa T, Breitschopf K, Ciechanover A, Schild L, Rotin D (1998). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170239">"Regulation of stability and function of the epithelial Na<sup>+</sup> channel (ENaC) by ubiquitination"</a>. <i>EMBO J</i>. <b>16</b> (21): 6325–36. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Femboj%2F16.21.6325">10.1093/emboj/16.21.6325</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170239">1170239</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9351815">9351815</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=EMBO+J.&rft.atitle=Regulation+of+stability+and+function+of+the+epithelial+Na%3Csup%3E%2B%3C%2Fsup%3E+channel+%28ENaC%29+by+ubiquitination&rft.volume=16&rft.issue=21&rft.pages=6325-36&rft.date=1998&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1170239%23id-name%3DPMC&rft_id=info%3Apmid%2F9351815&rft_id=info%3Adoi%2F10.1093%2Femboj%2F16.21.6325&rft.aulast=Staub&rft.aufirst=O&rft.au=Gautschi%2C+I&rft.au=Ishikawa%2C+T&rft.au=Breitschopf%2C+K&rft.au=Ciechanover%2C+A&rft.au=Schild%2C+L&rft.au=Rotin%2C+D&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1170239&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASCNN1G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAraiZachmanShibasakiChrousos1999" class="citation journal cs1">Arai K, Zachman K, Shibasaki T, Chrousos GP (1999). <a rel="nofollow" class="external text" href="https://doi.org/10.1210%2Fjcem.84.7.5857">"Polymorphisms of amiloride-sensitive sodium channel subunits in five sporadic cases of pseudohypoaldosteronism: do they have pathologic potential?"</a>. <i>J. 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Metab</i>. <b>84</b> (7): 2434–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1210%2Fjcem.84.7.5857">10.1210/jcem.84.7.5857</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10404817">10404817</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Clin.+Endocrinol.+Metab.&rft.atitle=Polymorphisms+of+amiloride-sensitive+sodium+channel+subunits+in+five+sporadic+cases+of+pseudohypoaldosteronism%3A+do+they+have+pathologic+potential%3F&rft.volume=84&rft.issue=7&rft.pages=2434-7&rft.date=1999&rft_id=info%3Adoi%2F10.1210%2Fjcem.84.7.5857&rft_id=info%3Apmid%2F10404817&rft.aulast=Arai&rft.aufirst=K&rft.au=Zachman%2C+K&rft.au=Shibasaki%2C+T&rft.au=Chrousos%2C+GP&rft_id=https%3A%2F%2Fdoi.org%2F10.1210%252Fjcem.84.7.5857&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASCNN1G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAuerbachLoftusItaniThomas2000" class="citation journal cs1">Auerbach SD, Loftus RW, Itani OA, Thomas CP (2000). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220937">"Human amiloride-sensitive epithelial Na<sup>+</sup> channel gamma subunit promoter: functional analysis and identification of a polypurine-polypyrimidine tract with the potential for triplex DNA formation"</a>. <i>Biochem. J</i>. <b>347</b> (1): 105–14. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1042%2F0264-6021%3A3470105">10.1042/0264-6021:3470105</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220937">1220937</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10727408">10727408</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochem.+J.&rft.atitle=Human+amiloride-sensitive+epithelial+Na%3Csup%3E%2B%3C%2Fsup%3E+channel+gamma+subunit+promoter%3A+functional+analysis+and+identification+of+a+polypurine-polypyrimidine+tract+with+the+potential+for+triplex+DNA+formation&rft.volume=347&rft.issue=1&rft.pages=105-14&rft.date=2000&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1220937%23id-name%3DPMC&rft_id=info%3Apmid%2F10727408&rft_id=info%3Adoi%2F10.1042%2F0264-6021%3A3470105&rft.aulast=Auerbach&rft.aufirst=SD&rft.au=Loftus%2C+RW&rft.au=Itani%2C+OA&rft.au=Thomas%2C+CP&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1220937&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASCNN1G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFShiAsherChigaevYung2002" class="citation journal cs1">Shi H, Asher C, Chigaev A, Yung Y, Reuveny E, Seger R, Garty H (2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M111717200">"Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation"</a>. <i>J. Biol. Chem</i>. <b>277</b> (16): 13539–47. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M111717200">10.1074/jbc.M111717200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11805112">11805112</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Interactions+of+beta+and+gamma+ENaC+with+Nedd4+can+be+facilitated+by+an+ERK-mediated+phosphorylation&rft.volume=277&rft.issue=16&rft.pages=13539-47&rft.date=2002&rft_id=info%3Adoi%2F10.1074%2Fjbc.M111717200&rft_id=info%3Apmid%2F11805112&rft.aulast=Shi&rft.aufirst=H&rft.au=Asher%2C+C&rft.au=Chigaev%2C+A&rft.au=Yung%2C+Y&rft.au=Reuveny%2C+E&rft.au=Seger%2C+R&rft.au=Garty%2C+H&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M111717200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASCNN1G" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=SCNN1G&action=edit&section=13" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a 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this template">e</abbr></a></li></ul></div><div id="Membrane_transport_protein:_ion_channels_(TC_1A)" style="font-size:114%;margin:0 4em"><a href="/wiki/Membrane_transport_protein" title="Membrane transport protein">Membrane transport protein</a>: <a href="/wiki/Ion_channel" title="Ion channel">ion channels</a> (<a href="/wiki/Transporter_Classification_Database#1._Channels/Pores" title="Transporter Classification Database">TC 1A</a>)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="Ca2+:_Calcium_channel" style="font-size:114%;margin:0 4em"><i>Ca<sup>2+</sup>:</i> <a href="/wiki/Calcium_channel" title="Calcium channel">Calcium channel</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;">Ligand-gated</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Inositol_trisphosphate_receptor" title="Inositol trisphosphate receptor">Inositol trisphosphate receptor</a> <ul><li><a href="/wiki/ITPR1" title="ITPR1">1</a></li> <li><a href="/wiki/ITPR2" title="ITPR2">2</a></li> <li><a href="/wiki/ITPR3" title="ITPR3">3</a></li></ul></li> <li><a href="/wiki/Ryanodine_receptor" title="Ryanodine receptor">Ryanodine receptor</a> <ul><li><a href="/wiki/RYR1" class="mw-redirect" title="RYR1">1</a></li> <li><a href="/wiki/Ryanodine_receptor_2" title="Ryanodine receptor 2">2</a></li> <li><a href="/wiki/RYR3" class="mw-redirect" title="RYR3">3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Voltage-gated_calcium_channel" title="Voltage-gated calcium channel">Voltage-gated</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/L-type_calcium_channel" title="L-type calcium channel">L-type</a>/<i>Ca<sub>v</sub>α</i> <ul><li><a href="/wiki/Cav1.1" title="Cav1.1">1.1</a></li> <li><a href="/wiki/Cav1.2" title="Cav1.2">1.2</a></li> <li><a href="/wiki/Cav1.3" title="Cav1.3">1.3</a></li> <li><a href="/wiki/Cav1.4" title="Cav1.4">1.4</a></li></ul></li> <li><a href="/wiki/N-type_calcium_channel" title="N-type calcium channel">N-type</a>/<i>Ca<sub>v</sub>α2.2</i></li> <li><a href="/wiki/P-type_calcium_channel" title="P-type calcium channel">P-type</a>/<i>Ca<sub>v</sub>α</i> <ul><li><a href="/wiki/Cav2.1" title="Cav2.1">2.1</a></li></ul></li> <li><a href="/wiki/Q-type_calcium_channel" title="Q-type calcium channel">Q-type</a>/<i>Ca<sub>v</sub>α2.1</i></li> <li><a href="/wiki/R-type_calcium_channel" title="R-type calcium channel">R-type</a>/<i>Ca<sub>v</sub>α2.3</i></li> <li><a href="/wiki/T-type_calcium_channel" title="T-type calcium channel">T-type</a>/<i>Ca<sub>v</sub>α</i> <ul><li><a href="/wiki/CACNA1G" title="CACNA1G">3.1</a></li> <li><a href="/wiki/CACNA1H" class="mw-redirect" title="CACNA1H">3.2</a></li> <li><a href="/wiki/CACNA1I" title="CACNA1I">3.3</a></li></ul></li></ul> <ul><li><i>α<sub>2</sub>δ-subunits</i> <ul><li><a href="/wiki/CACNA2D1" title="CACNA2D1">1</a></li> <li><a href="/wiki/CACNA2D2" title="CACNA2D2">2</a></li></ul></li> <li><i>β-subunits</i> <ul><li><a href="/wiki/CACNB1" title="CACNB1">β1</a></li> <li><a href="/wiki/CACNB2" title="CACNB2">β2</a></li> <li><a href="/wiki/CACNB3" title="CACNB3">β3</a></li> <li><a href="/wiki/CACNB4" title="CACNB4">β4</a></li></ul></li> <li><i>γ-subunits</i> <ul><li><a href="/wiki/CACNG1" title="CACNG1">γ1</a></li> <li><a href="/wiki/CACNG2" title="CACNG2">γ2</a></li> <li><a href="/wiki/CACNG3" title="CACNG3">γ3</a></li> <li><a href="/wiki/CACNG4" title="CACNG4">γ4</a></li></ul></li></ul> <ul><li><a href="/wiki/Cation_channels_of_sperm" title="Cation channels of sperm">Cation channels of sperm</a> <ul><li><a href="/wiki/CatSper1" title="CatSper1">1</a></li> <li><a href="/wiki/CatSper2" title="CatSper2">2</a></li> <li><a href="/wiki/CatSper3" title="CatSper3">3</a></li> <li><a href="/wiki/CatSper4" title="CatSper4">4</a></li></ul></li> <li><a href="/wiki/Two-pore_channel" title="Two-pore channel">Two-pore channel</a> <ul><li><a href="/wiki/TPCN1" title="TPCN1">1</a></li> <li><a href="/wiki/TPCN2" title="TPCN2">2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="Na+:_Sodium_channel" style="font-size:114%;margin:0 4em"><i>Na<sup>+</sup>:</i> <a href="/wiki/Sodium_channel" title="Sodium channel">Sodium channel</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;">Constitutively active</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Epithelial_sodium_channel" title="Epithelial sodium channel">Epithelial sodium channel</a> <ul><li><a href="/wiki/SCNN1A" title="SCNN1A">α</a></li> <li><a href="/wiki/SCNN1B" title="SCNN1B">β</a></li> <li><a class="mw-selflink selflink">γ</a></li> <li><a href="/wiki/SCNN1D" title="SCNN1D">δ</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Hydron_(chemistry)" title="Hydron (chemistry)">Proton</a>-gated</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acid-sensing_ion_channel" title="Acid-sensing ion channel">Amiloride-sensitive cation channel</a> <ul><li><a href="/wiki/ACCN1" class="mw-redirect" title="ACCN1">1</a></li> <li><a href="/wiki/ACCN2" class="mw-redirect" title="ACCN2">2</a></li> <li><a href="/wiki/ACCN3" class="mw-redirect" title="ACCN3">3</a></li> <li><a href="/wiki/ACCN4" class="mw-redirect" title="ACCN4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Voltage-gated_sodium_channel" title="Voltage-gated sodium channel">Voltage-gated</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>Na<sub>v</sub>α</i> <ul><li><a href="/wiki/Nav1.1" class="mw-redirect" title="Nav1.1">1.1</a></li> <li><a href="/wiki/Nav1.2" class="mw-redirect" title="Nav1.2">1.2</a></li> <li><a href="/wiki/SCN3A" title="SCN3A">1.3</a></li> <li><a href="/wiki/Nav1.4" title="Nav1.4">1.4</a></li> <li><a href="/wiki/Nav1.5" class="mw-redirect" title="Nav1.5">1.5</a></li> <li><a href="/wiki/SCN8A" title="SCN8A">1.6</a></li> <li><a href="/wiki/Nav1.7" class="mw-redirect" title="Nav1.7">1.7</a></li> <li><a href="/wiki/SCN10A" class="mw-redirect" title="SCN10A">1.8</a></li> <li><a href="/wiki/Nav1.9" title="Nav1.9">1.9</a></li> <li><a href="/wiki/SCN7A" title="SCN7A">7A</a></li></ul></li> <li><i>Na<sub>v</sub>β</i> <ul><li><a href="/wiki/SCN1B" title="SCN1B">1</a></li> <li><a href="/wiki/SCN2B" title="SCN2B">2</a></li> <li><a href="/wiki/SCN3B" title="SCN3B">3</a></li> <li><a href="/wiki/SCN4B" title="SCN4B">4</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="K+:_Potassium_channel" style="font-size:114%;margin:0 4em"><i>K<sup>+</sup>:</i> <a href="/wiki/Potassium_channel" title="Potassium channel">Potassium channel</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Calcium-activated_potassium_channel" title="Calcium-activated potassium channel">Calcium-activated</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BK_channel" title="BK channel">BK channel</a> <ul><li><a href="/wiki/Calcium-activated_potassium_channel_subunit_alpha-1" title="Calcium-activated potassium channel subunit alpha-1">α1</a></li> <li><a href="/wiki/KCNMB1" title="KCNMB1">β1</a></li> <li><a href="/wiki/KCNMB2" title="KCNMB2">β2</a></li> <li><a href="/wiki/KCNMB3" title="KCNMB3">β3</a></li> <li><a href="/wiki/KCNMB4" title="KCNMB4">β4</a></li></ul></li> <li><a href="/wiki/SK_channel" title="SK channel">SK channel</a> <ul><li><a href="/wiki/KCNN1" title="KCNN1">SK1</a></li> <li><a href="/wiki/KCNN2" title="KCNN2">SK2</a></li> <li><a href="/wiki/SK3" title="SK3">SK3</a></li></ul></li> <li>IK channel <ul><li><a href="/wiki/KCNN4" title="KCNN4">IK1</a></li></ul></li> <li><i>K<sub>Ca</sub></i> <ul><li><a href="/wiki/Calcium-activated_potassium_channel_subunit_alpha-1" title="Calcium-activated potassium channel subunit alpha-1">1.1</a></li> <li><a href="/wiki/KCNN1" title="KCNN1">2.1</a></li> <li><a href="/wiki/KCNN2" title="KCNN2">2.2</a></li> <li><a href="/wiki/SK3" title="SK3">2.3</a></li> <li><a href="/wiki/KCNN4" title="KCNN4">3.1</a></li> <li><a href="/wiki/KCNT1" title="KCNT1">4.1</a></li> <li><a href="/wiki/KCNT2" title="KCNT2">4.2</a></li> <li><a href="/wiki/KCNU1" title="KCNU1">5.1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Inward-rectifier_potassium_ion_channel" class="mw-redirect" title="Inward-rectifier potassium ion channel">Inward-rectifier</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ATP-sensitive_potassium_channel" title="ATP-sensitive potassium channel">K<sub>ATP</sub></a></li> <li><i>K<sub>ir</sub></i> <ul><li><a href="/wiki/ROMK" title="ROMK">1.1</a></li> <li><a href="/wiki/Kir2.1" title="Kir2.1">2.1</a></li> <li><a href="/wiki/KCNJ12" title="KCNJ12">2.2</a></li> <li><a href="/wiki/KCNJ4" title="KCNJ4">2.3</a></li> <li><a href="/wiki/KCNJ14" title="KCNJ14">2.4</a></li> <li><a href="/wiki/Kir2.6" title="Kir2.6">2.6</a></li></ul></li> <li><a href="/wiki/G_protein-coupled_inwardly_rectifying_potassium_channel" title="G protein-coupled inwardly rectifying potassium channel">GIRK</a>/<i>K<sub>ir</sub></i> <ul><li><a href="/wiki/KCNJ3" title="KCNJ3">3.1</a></li> <li><a href="/wiki/KCNJ6" title="KCNJ6">3.2</a></li> <li><a href="/wiki/KCNJ9" title="KCNJ9">3.3</a></li> <li><a href="/wiki/KCNJ5" title="KCNJ5">3.4</a></li></ul></li> <li><i>K<sub>ir</sub></i> <ul><li><a href="/wiki/KCNJ10" title="KCNJ10">4.1</a></li> <li><a href="/wiki/KCNJ15" title="KCNJ15">4.2</a></li> <li><a href="/wiki/KCNJ16" title="KCNJ16">5.1</a></li> <li><a href="/wiki/KCNJ8" title="KCNJ8">6.1</a></li> <li><a href="/wiki/Kir6.2" title="Kir6.2">6.2</a></li> <li><a href="/wiki/KCNJ13" title="KCNJ13">7.1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Tandem_pore_domain_potassium_channel" class="mw-redirect" title="Tandem pore domain potassium channel">Tandem pore domain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>K2P</i> <ul><li><a href="/wiki/KCNK1" title="KCNK1">1</a></li> <li><a href="/wiki/KCNK2" title="KCNK2">2</a></li> <li><a href="/wiki/KCNK3" title="KCNK3">3</a></li> <li><a href="/wiki/KCNK4" title="KCNK4">4</a></li> <li><a href="/wiki/KCNK5" title="KCNK5">5</a></li> <li><a href="/wiki/KCNK6" title="KCNK6">6</a></li> <li><a href="/wiki/KCNK7" title="KCNK7">7</a></li> <li><a href="/wiki/KCNK9" title="KCNK9">9</a></li> <li><a href="/wiki/KCNK10" title="KCNK10">10</a></li> <li><a href="/wiki/KCNK12" title="KCNK12">12</a></li> <li><a href="/wiki/KCNK13" title="KCNK13">13</a></li> <li><a href="/wiki/KCNK15" title="KCNK15">15</a></li> <li><a href="/wiki/KCNK16" title="KCNK16">16</a></li> <li><a href="/wiki/KCNK17" title="KCNK17">17</a></li> <li><a href="/wiki/KCNK18" title="KCNK18">18</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Voltage-gated_potassium_channel" title="Voltage-gated potassium channel">Voltage-gated</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>K<sub>v</sub>α1-6</i> <ul><li><a href="/wiki/Kv1.1" title="Kv1.1">1.1</a></li> <li><a href="/wiki/KCNA2" title="KCNA2">1.2</a></li> <li><a href="/wiki/KCNA3" title="KCNA3">1.3</a></li> <li><a href="/wiki/KCNA4" title="KCNA4">1.4</a></li> <li><a href="/wiki/KCNA5" title="KCNA5">1.5</a></li> <li><a href="/wiki/KCNA6" title="KCNA6">1.6</a></li> <li><a href="/wiki/KCNA7" title="KCNA7">1.7</a></li> <li><a href="/wiki/KCNA10" title="KCNA10">1.8</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNB1" title="KCNB1">2.1</a></li> <li><a href="/wiki/KCNB2" title="KCNB2">2.2</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNC1" title="KCNC1">3.1</a></li> <li><a href="/wiki/KCNC2" title="KCNC2">3.2</a></li> <li><a href="/wiki/KCNC3" title="KCNC3">3.3</a></li> <li><a href="/wiki/KCNC4" title="KCNC4">3.4</a></li></ul></li> <li> <ul><li><a href="/wiki/KCND1" title="KCND1">4.1</a></li> <li><a href="/wiki/KCND2" title="KCND2">4.2</a></li> <li><a href="/wiki/KCND3" title="KCND3">4.3</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNF1" title="KCNF1">5.1</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNG1" title="KCNG1">6.1</a></li> <li><a href="/wiki/KCNG2" title="KCNG2">6.2</a></li> <li><a href="/wiki/KCNG3" title="KCNG3">6.3</a></li> <li><a href="/wiki/KCNG4" title="KCNG4">6.4</a></li></ul></li></ul> <ul><li><i>K<sub>v</sub>α7-12</i> <ul><li><a href="/wiki/KvLQT1" title="KvLQT1">7.1</a></li> <li><a href="/wiki/KvLQT2" title="KvLQT2">7.2</a></li> <li><a href="/wiki/KvLQT3" title="KvLQT3">7.3</a></li> <li><a href="/wiki/KCNQ4" title="KCNQ4">7.4</a></li> <li><a href="/wiki/KCNQ5" title="KCNQ5">7.5</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNV1" title="KCNV1">8.1</a></li> <li><a href="/wiki/KCNV2" title="KCNV2">8.2</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNS1" title="KCNS1">9.1</a></li> <li><a href="/wiki/KCNS2" title="KCNS2">9.2</a></li> <li><a href="/wiki/KCNS3" title="KCNS3">9.3</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNH1" title="KCNH1">10.1</a></li> <li><a href="/wiki/KCNH5" title="KCNH5">10.2</a></li></ul></li> <li> <ul><li><a href="/wiki/HERG" title="HERG">11.1/hERG</a></li> <li><a href="/wiki/KCNH6" title="KCNH6">11.2</a></li> <li><a href="/wiki/KCNH7" title="KCNH7">11.3</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNH8" title="KCNH8">12.1</a></li> <li><a href="/wiki/KCNH3" title="KCNH3">12.2</a></li> <li><a href="/wiki/KCNH4" title="KCNH4">12.3</a></li></ul></li></ul> <ul><li><i>K<sub>v</sub>β</i> <ul><li><a href="/wiki/KCNAB1" title="KCNAB1">1</a></li> <li><a href="/wiki/KCNAB2" title="KCNAB2">2</a></li> <li><a href="/wiki/KCNAB3" title="KCNAB3">3</a></li></ul></li> <li><i>KCNIP</i> <ul><li><a href="/wiki/KCNIP1" title="KCNIP1">1</a></li> <li><a href="/wiki/KCNIP2" title="KCNIP2">2</a></li> <li><a href="/wiki/Calsenilin" title="Calsenilin">3</a></li> <li><a href="/wiki/KCNIP4" title="KCNIP4">4</a></li></ul></li> <li><a href="/wiki/KCNE1" title="KCNE1">minK/ISK</a></li> <li><a href="/wiki/KCNE1L" class="mw-redirect" title="KCNE1L">minK/ISK-like</a></li> <li><i>MiRP</i> <ul><li><a href="/wiki/KCNE2" title="KCNE2">1</a></li> <li><a href="/wiki/KCNE3" title="KCNE3">2</a></li> <li><a href="/wiki/KCNE4" title="KCNE4">3</a></li></ul></li> <li><a href="/wiki/Shaker_(gene)" title="Shaker (gene)">Shaker (gene)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="Miscellaneous" style="font-size:114%;margin:0 4em"><i>Miscellaneous</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Chloride" title="Chloride">Cl<sup>−</sup></a>:</i> <a href="/wiki/Chloride_channel" title="Chloride channel">Chloride channel</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcium-activated_chloride_channel" class="mw-redirect" title="Calcium-activated chloride channel">Calcium-activated chloride channels</a> <ul><li><i>Anoctamin</i> <ul><li><a href="/wiki/ANO1" title="ANO1">ANO1</a></li></ul></li> <li><i>Bestrophin</i> <ul><li><a href="/wiki/Bestrophin_1" title="Bestrophin 1">1</a></li> <li><a href="/wiki/BEST2" class="mw-redirect" title="BEST2">2</a></li></ul></li> <li><i>Chloride Channel Accessory</i> <ul><li><a href="/wiki/CLCA1" title="CLCA1">1</a></li> <li><a href="/wiki/CLCA2" title="CLCA2">2</a></li> <li><a href="/wiki/CLCA3" title="CLCA3">3</a></li> <li><a href="/wiki/CLCA4" title="CLCA4">4</a></li></ul></li></ul></li> <li><a href="/wiki/Cystic_fibrosis_transmembrane_conductance_regulator" title="Cystic fibrosis transmembrane conductance regulator">CFTR</a></li> <li><i>CLCN</i> <ul><li><a href="/wiki/CLCN1" title="CLCN1">1</a></li> <li><a href="/wiki/CLCN2" title="CLCN2">2</a></li> <li><a href="/wiki/CLCN3" title="CLCN3">3</a></li> <li><a href="/wiki/CLCN4" title="CLCN4">4</a></li> <li><a href="/wiki/CLCN5" title="CLCN5">5</a></li> <li><a href="/wiki/CLCN6" title="CLCN6">6</a></li> <li><a href="/wiki/CLCN7" title="CLCN7">7</a></li> <li><a href="/wiki/CLCNKA" title="CLCNKA">KA</a></li> <li><a href="/wiki/CLCNKB" title="CLCNKB">KB</a></li></ul></li> <li><i>CLIC</i> <ul><li><a href="/wiki/CLIC1" title="CLIC1">1</a></li> <li><a href="/wiki/CLIC2" title="CLIC2">2</a></li> <li><a href="/wiki/CLIC3" title="CLIC3">3</a></li> <li><a href="/wiki/CLIC4" title="CLIC4">4</a></li> <li><a href="/wiki/CLIC5" title="CLIC5">5</a></li> <li><a href="/wiki/CLIC6" title="CLIC6">6</a></li> <li><a href="/wiki/CLCC1" title="CLCC1">L1</a></li></ul></li> <li><i>CLNS</i> <ul><li><a href="/wiki/CLNS1A" title="CLNS1A">1A</a></li> <li><a href="/wiki/CLNS1B" title="CLNS1B">1B</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Hydron_(chemistry)" title="Hydron (chemistry)">H<sup>+</sup></a>:</i> <a href="/wiki/Voltage-gated_proton_channel" title="Voltage-gated proton channel">Proton channel</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HVCN1" title="HVCN1">HVCN1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Ion#Anions_and_cations" title="Ion">M<sup>+</sup></a>:</i> <a href="/wiki/Cyclic_nucleotide-gated_ion_channel" class="mw-redirect" title="Cyclic nucleotide-gated ion channel">CNG cation channel</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>α</i> <ul><li><a href="/wiki/Cyclic_nucleotide-gated_channel_alpha_1" title="Cyclic nucleotide-gated channel alpha 1">1</a></li> <li><a href="/wiki/Cyclic_nucleotide-gated_channel_alpha_2" title="Cyclic nucleotide-gated channel alpha 2">2</a></li> <li><a href="/wiki/Cyclic_nucleotide-gated_channel_alpha_3" title="Cyclic nucleotide-gated channel alpha 3">3</a></li> <li><a href="/wiki/Cyclic_nucleotide-gated_channel_alpha_4" title="Cyclic nucleotide-gated channel alpha 4">4</a></li></ul></li> <li><i>β</i> <ul><li><a href="/wiki/CNGB1" title="CNGB1">1</a></li> <li><a href="/wiki/Cyclic_nucleotide-gated_channel_alpha_4" title="Cyclic nucleotide-gated channel alpha 4">2</a></li> <li><a href="/wiki/Cyclic_nucleotide_gated_channel_beta_3" title="Cyclic nucleotide gated channel beta 3">3</a></li></ul></li> <li><i><a href="/wiki/HCN_channel" title="HCN channel">HCN</a></i> <ul><li><a href="/wiki/Funny_current" class="mw-redirect" title="Funny current">FC</a></li> <li><a href="/wiki/HCN1" title="HCN1">1</a></li> <li><a href="/wiki/HCN2" title="HCN2">2</a></li> <li><a href="/wiki/HCN3" title="HCN3">3</a></li> <li><a href="/wiki/HCN4" title="HCN4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Ion#Anions_and_cations" title="Ion">M<sup>+</sup></a>:</i> <a href="/wiki/Transient_receptor_potential_channel" title="Transient receptor potential channel">TRP cation channel</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TRPA_(channel)" class="mw-redirect" title="TRPA (channel)">TRPA</a> (<a href="/wiki/Transient_receptor_potential_cation_channel,_member_A1" class="mw-redirect" title="Transient receptor potential cation channel, member A1">1</a>)</li> <li><a href="/wiki/TRPC" title="TRPC">TRPC</a> <ul><li><a href="/wiki/TRPC1" title="TRPC1">1</a></li> <li><a href="/wiki/TRPC2" title="TRPC2">2</a></li> <li><a href="/wiki/TRPC3" title="TRPC3">3</a></li> <li><a href="/wiki/TRPC4" title="TRPC4">4</a></li> <li><a href="/wiki/TRPC4AP" title="TRPC4AP">4AP</a></li> <li><a href="/wiki/TRPC5" title="TRPC5">5</a></li> <li><a href="/wiki/TRPC6" title="TRPC6">6</a></li> <li><a href="/wiki/TRPC7" title="TRPC7">7</a></li></ul></li> <li><a href="/wiki/TRPM" title="TRPM">TRPM</a> <ul><li><a href="/wiki/TRPM1" title="TRPM1">1</a></li> <li><a href="/wiki/TRPM2" title="TRPM2">2</a></li> <li><a href="/wiki/TRPM3" title="TRPM3">3</a></li> <li><a href="/wiki/TRPM4" title="TRPM4">4</a></li> <li><a href="/wiki/TRPM5" title="TRPM5">5</a></li> <li><a href="/wiki/TRPM6" title="TRPM6">6</a></li> <li><a href="/wiki/TRPM7" title="TRPM7">7</a></li> <li><a href="/wiki/TRPM8" title="TRPM8">8</a></li></ul></li> <li><a href="/wiki/TRPML" title="TRPML">TRPML</a> <ul><li><a href="/wiki/Mucolipin-1" class="mw-redirect" title="Mucolipin-1">1</a></li> <li><a href="/wiki/MCOLN2" title="MCOLN2">2</a></li> <li><a href="/wiki/MCOLN3" title="MCOLN3">3</a></li></ul></li> <li><a href="/wiki/TRPN" title="TRPN">TRPN</a></li> <li><a href="/wiki/TRPP" title="TRPP">TRPP</a> <ul><li><a href="/wiki/PKD1" class="mw-redirect" title="PKD1">1</a></li> <li><a href="/wiki/Polycystic_kidney_disease_2" class="mw-redirect" title="Polycystic kidney disease 2">2</a></li></ul></li> <li><a href="/wiki/TRPV" title="TRPV">TRPV</a> <ul><li><a href="/wiki/TRPV1" title="TRPV1">1</a></li> <li><a href="/wiki/TRPV2" title="TRPV2">2</a></li> <li><a href="/wiki/TRPV3" title="TRPV3">3</a></li> <li><a href="/wiki/TRPV4" title="TRPV4">4</a></li> <li><a href="/wiki/TRPV5" title="TRPV5">5</a></li> <li><a href="/wiki/TRPV6" title="TRPV6">6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Water" title="Water">H<sub>2</sub>O</a> (+ <a href="/wiki/Solutes" class="mw-redirect" title="Solutes">solutes</a>):</i> <a href="/wiki/Porin_(protein)" title="Porin (protein)">Porin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aquaporin" title="Aquaporin">Aquaporin</a> <ul><li><a href="/wiki/MIP_(gene)" class="mw-redirect" title="MIP (gene)">0</a></li> <li><a href="/wiki/Aquaporin_1" class="mw-redirect" title="Aquaporin 1">1</a></li> <li><a href="/wiki/Aquaporin_2" class="mw-redirect" title="Aquaporin 2">2</a></li> <li><a href="/wiki/Aquaporin_3" class="mw-redirect" title="Aquaporin 3">3</a></li> <li><a href="/wiki/Aquaporin_4" class="mw-redirect" title="Aquaporin 4">4</a></li> <li><a href="/wiki/AQP5" class="mw-redirect" title="AQP5">5</a></li> <li><a href="/wiki/AQP6" class="mw-redirect" title="AQP6">6</a></li> <li><a href="/wiki/AQP7" class="mw-redirect" title="AQP7">7</a></li> <li><a href="/wiki/AQP8" class="mw-redirect" title="AQP8">8</a></li> <li><a href="/wiki/AQP9" class="mw-redirect" title="AQP9">9</a></li></ul></li> <li><a href="/wiki/Voltage-dependent_anion_channel" title="Voltage-dependent anion channel">Voltage-dependent anion channel</a> <ul><li><a href="/wiki/VDAC1" title="VDAC1">1</a></li> <li><a href="/wiki/VDAC2" title="VDAC2">2</a></li> <li><a href="/wiki/VDAC3" title="VDAC3">3</a></li></ul></li> <li><a href="/wiki/General_bacterial_porin_family" title="General bacterial porin family">General bacterial porin family</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Cytoplasm" title="Cytoplasm">Cytoplasm</a>:</i> <a href="/wiki/Gap_junction" title="Gap junction">Gap junction</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Connexin" title="Connexin">Connexin</a> <ul><li>A <ul><li><a href="/wiki/GJA1" title="GJA1">GJA1</a></li> <li><a href="/wiki/GJA3" title="GJA3">GJA3</a></li> <li><a href="/wiki/GJA4" title="GJA4">GJA4</a></li> <li><a href="/wiki/GJA5" title="GJA5">GJA5</a></li> <li><a href="/wiki/GJA8" title="GJA8">GJA8</a></li> <li><a href="/wiki/GJD2" title="GJD2">GJA9</a></li> <li><a href="/wiki/GJA10" title="GJA10">GJA10</a></li></ul></li> <li>B <ul><li><a href="/wiki/GJB1" title="GJB1">GJB1</a></li> <li><a href="/wiki/GJB2" title="GJB2">GJB2</a></li> <li><a href="/wiki/GJB3" title="GJB3">GJB3</a></li> <li><a href="/wiki/GJB4" title="GJB4">GJB4</a></li> <li><a href="/wiki/GJB5" title="GJB5">GJB5</a></li> <li><a href="/wiki/GJB6" title="GJB6">GJB6</a></li> <li><a href="/wiki/GJB7" title="GJB7">GJB7</a></li></ul></li> <li>C <ul><li><a href="/wiki/GJC1" title="GJC1">GJC1</a></li> <li><a href="/wiki/GJC2" title="GJC2">GJC2</a></li> <li><a href="/wiki/GJC3" title="GJC3">GJC3</a></li></ul></li> <li>D <ul><li><a href="/wiki/GJD2" title="GJD2">GJD2</a></li> <li><a href="/wiki/GJD3" title="GJD3">GJD3</a></li> <li><a href="/wiki/GJD4" title="GJD4">GJD4</a></li></ul></li></ul></li> <li><a href="/wiki/Innexin" title="Innexin">Innexin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="By_gating_mechanism" style="font-size:114%;margin:0 4em"><i>By gating mechanism</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Ion_channel_class" scope="row" class="navbox-group" style="width:15em;text-align:left;"><i>Ion channel class</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ligand-gated_ion_channel" title="Ligand-gated ion channel">Ligand-gated</a></li> <li><a href="/wiki/Light-gated_ion_channel" title="Light-gated ion channel">Light-gated</a></li> <li><a href="/wiki/Voltage-gated_ion_channel" title="Voltage-gated ion channel">Voltage-gated</a></li> <li><a href="/wiki/Stretch-activated_ion_channel" class="mw-redirect" title="Stretch-activated ion channel">Stretch-activated</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite; padding: 0px;"><div><i>see also <a href="/wiki/Template:Channelopathy" title="Template:Channelopathy">disorders</a></i></div></td></tr></tbody></table></div>    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