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Adaptation to extrauterine life - Wikipedia
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Unsourced or poorly sourced material may be challenged and <a href="/wiki/Wikipedia:Verifiability#Burden_of_evidence" title="Wikipedia:Verifiability">removed</a>. <small><span class="plainlinks"><i>Find sources:</i> <a rel="nofollow" class="external text" href="https://www.google.com/search?as_eq=wikipedia&q=%22Adaptation+to+extrauterine+life%22">"Adaptation to extrauterine life"</a> – <a rel="nofollow" class="external text" href="https://www.google.com/search?tbm=nws&q=%22Adaptation+to+extrauterine+life%22+-wikipedia&tbs=ar:1">news</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?&q=%22Adaptation+to+extrauterine+life%22&tbs=bkt:s&tbm=bks">newspapers</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?tbs=bks:1&q=%22Adaptation+to+extrauterine+life%22+-wikipedia">books</a> <b>·</b> <a rel="nofollow" class="external text" href="https://scholar.google.com/scholar?q=%22Adaptation+to+extrauterine+life%22">scholar</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.jstor.org/action/doBasicSearch?Query=%22Adaptation+to+extrauterine+life%22&acc=on&wc=on">JSTOR</a></span></small></span> <span class="date-container"><i>(<span class="date">November 2018</span>)</i></span></div></td><td class="mbox-imageright"><div class="mbox-image-div"><span typeof="mw:File"><span><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/52px-Star_of_life.svg.png" decoding="async" width="52" height="50" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/77px-Star_of_life.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/103px-Star_of_life.svg.png 2x" data-file-width="198" data-file-height="192" /></span></span></div></td></tr></tbody></table> <p class="mw-empty-elt"> </p><p>At the end of <a href="/wiki/Pregnancy" title="Pregnancy">pregnancy</a>, the <a href="/wiki/Fetus" title="Fetus">fetus</a> must take the journey of <a href="/wiki/Childbirth" title="Childbirth">childbirth</a> to leave the <a href="/wiki/Reproductive" class="mw-redirect" title="Reproductive">reproductive</a> <a href="/wiki/Mother" title="Mother">mother</a>. Upon its entry to the air-breathing world, the <a href="/wiki/Newborn" class="mw-redirect" title="Newborn">newborn</a> must begin to adjust to life outside the <a href="/wiki/Uterus" title="Uterus">uterus</a>. This is true for all <a href="/wiki/Viviparous" class="mw-redirect" title="Viviparous">viviparous</a> animals; this article discusses humans as the most-researched example.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (December 2021)">citation needed</span></a></i>]</sup> </p><p>The outside environment is a drastic change for the neonate, therefore the neonate must be assessed frequently and thoroughly. The <a href="/wiki/Apgar_score" title="Apgar score">Apgar scale</a> is an assessment performed immediately following birth. It consists of the assessment of heart rate, respiratory effort, muscle tone, reflex irritability, and generalized skin color. Apgar scoring is performed one minute and five minutes after birth. Scoring ranges from 0 to 10, with 0 indicating severe neonatal distress and 10 indicating a smooth transition to extrauterine life.<sup id="cite_ref-Lowdermilk_1-0" class="reference"><a href="#cite_note-Lowdermilk-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>Newborns transitioning into extrauterine life will undergo periods of reactivity. These periods are divided into three stages. The first stage occurs in the first 30 minutes of life; during this stage the infant is alert and responsive with heart rate peaking at 160-180 beats per minute and then stabilizes to a baseline rate of 100-120 beats per minute. Crackles upon auscultation and irregular respirations are a normal finding. In the second stage, there is a decrease in responsiveness and motor activity which is often manifested as sleep. This period can last from 1–2 hours. The third stage marks the second period of reactivity. This period can occur anywhere in the first 2 to 8 hours after birth and lasts anywhere from 10 minutes to several hours. <a href="/wiki/Tachycardia" title="Tachycardia">Tachycardia</a> and <a href="/wiki/Tachypnea" title="Tachypnea">tachypnea</a> may be present during brief periods. Passing of <a href="/wiki/Meconium" title="Meconium">meconium</a> also occurs.<sup id="cite_ref-Lowdermilk_1-1" class="reference"><a href="#cite_note-Lowdermilk-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Cardiac">Cardiac</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adaptation_to_extrauterine_life&action=edit&section=1" title="Edit section: Cardiac"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Physiology: In utero, the placenta delivers oxygenated blood to the fetus through the umbilical vein. Upon delivery, the umbilical cord is cut. The cardiovascular system must now adapt. Blood CO<sub>2</sub> rises because it is now not removed by the placenta. This is a powerful stimulus for the infant to start breathing. Breathing sharply increases O<sub>2</sub> in the lungs, thus quickly reverting hypoxic pulmonary vasoconstriction that had held the pulmonary vascular resistance high during the uterine life. Lung ventilation also extends the so far convoluted, shrunk pulmonary vessels, also contributing to the quick and marked drop in the pulmonary vascular resistance. As a result, much higher proportion of the right ventricle output flows into the pulmonary vessels than into the systemic circulation through the ductus arteriosus. The detachment of the placenta causes an increase in systemic vascular resistance, which leads to an increase in pressure gradient from the left atrium.<sup id="cite_ref-Morton_2-0" class="reference"><a href="#cite_note-Morton-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> The left atrium now has higher pressure than the right atrium causing the <a href="/wiki/Foramen_ovale_(heart)" title="Foramen ovale (heart)">foramen ovale</a> to close. Within the first 10 minutes of birth, blood begins to flow left-to-right through the <a href="/wiki/Ductus_arteriosus" title="Ductus arteriosus">ductus arteriosus</a>. This causes a significant increase in output of the left ventricle and increase in stroke volume. Subsequently, <a href="/wiki/Calcium_channel" title="Calcium channel">calcium channel</a> activity increases and potassium channel decreases furthering ductal constriction. Functional closure of the ductus arteriosus occurs within the first 24 hours, with permanent closure following within 4 weeks. Lastly cardiac output increases to nearly double what it was in utero. All of these <a href="/wiki/Cardiovascular_system" class="mw-redirect" title="Cardiovascular system">cardiovascular system</a> changes result in the adaptation from fetal circulation patterns to an <a href="/wiki/Adult" title="Adult">adult</a> <a href="/wiki/Circulatory_system" title="Circulatory system">circulation</a> pattern. During this transition, some types of congenital heart disease that were not symptomatic <i><a href="/wiki/Uterus" title="Uterus">in utero</a></i> during fetal circulation will present with <a href="/wiki/Cyanosis" title="Cyanosis">cyanosis</a> or <a href="/wiki/Respiration_(physiology)" title="Respiration (physiology)">respiratory</a> signs. </p> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Postnatal_genetics_en.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/87/Postnatal_genetics_en.svg/300px-Postnatal_genetics_en.svg.png" decoding="async" width="300" height="229" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/87/Postnatal_genetics_en.svg/450px-Postnatal_genetics_en.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/87/Postnatal_genetics_en.svg/600px-Postnatal_genetics_en.svg.png 2x" data-file-width="800" data-file-height="610" /></a><figcaption>Changing the composition of hemoglobin before and after birth. Also identifies the types of cells and organs in which the gene expression (data on <i>Wood W.G.</i>, (1976). <b>Br. Med. Bull. 32, 282.</b>)</figcaption></figure> <p>Manifestations: When the newborn cries, there is a reversal of blood flow through the foramen ovale which causes the newborn to appear mildly cyanotic in the first few days of life. The heart rate of the newborn should be between 110 and 160 beats per minute and it is common for the heart rate to be irregular in the first few hours following birth. The heart sounds will have a variation in pitch, duration, and intensity than that of an adult. Blood pressure readings should range from 60 to 80 mm Hg systolic and 40–50 mm Hg diastolic. Mean arterial pressure should be the same as the weeks of <a href="/wiki/Gestation" title="Gestation">gestation</a> at birth. Within the first hour after birth, there may be a drop of up to 15 mm Hg in the systolic blood pressure.<sup id="cite_ref-Lowdermilk_1-2" class="reference"><a href="#cite_note-Lowdermilk-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Delayed_cord_clamping" class="mw-redirect" title="Delayed cord clamping">Delayed cord clamping</a> is defined as waiting more than 2 minutes to clamp the newborn's <a href="/wiki/Umbilical_cord" title="Umbilical cord">umbilical cord</a>. This has been proven to be beneficial in improving hematocrit and iron while also decreasing anemia. These benefits can last up to 6 months for the newborn.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>Assessments/Interventions: Assessment and monitoring of vital signs and skin color are important in detecting cardiovascular issues in the infant. The apical pulse rate should be auscultated for one full minute when the newborn is calm or sleeping. Any irregular heart rate after the first few hours of life that is not related to crying or another outside factor should be monitored and evaluated.<sup id="cite_ref-Lowdermilk_1-3" class="reference"><a href="#cite_note-Lowdermilk-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Blood pressure will be taken with an appropriately sized cuff, preferably when the newborn is at rest. Consistent tachycardia should be evaluated for conditions such as anemia, hyperthermia, hypovolemia, and sepsis. Consistent bradycardia could be an indication of congenital heart block or hypoxemia. Pallor and central cyanosis (cyanosis in hands and feet is a common and normal finding) can also indicate cardiovascular issues.<sup id="cite_ref-Lowdermilk_1-4" class="reference"><a href="#cite_note-Lowdermilk-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Ventilation_and_Oxygenation">Ventilation and Oxygenation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adaptation_to_extrauterine_life&action=edit&section=2" title="Edit section: Ventilation and Oxygenation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Physiology: Upon birth, the newborn's lungs become the center for gas exchange. There are a variety of factors that influence newborn respiratory functions; these factors include chemical, mechanical, thermal, and sensory. Respirations begin when fetal aortic and carotid chemoreceptors are stimulated by the varying concentrations of oxygen and carbon dioxide. During vaginal birth, the newborn's chest is compressed by the birth canal. Upon delivery, negative pressure allows air into the lungs. The first cries of the infant allow for alveoli expansion and absorption of fetal lung fluid. Temperature changes and other sensory stimulation contributes to respiratory function as well. </p><p>Manifestations: Breathing patterns are often irregular and shallow. The infants respiration rate should be between 30 and 60 breaths per minute with preference for nasal breathing. Ribs expands horizontally. Breath sounds should be clear and equal in both lungs. Abdominal breathing is normal. Acrocyanosis is a normal finding.<sup id="cite_ref-Lowdermilk_1-5" class="reference"><a href="#cite_note-Lowdermilk-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>Assessments/Interventions: Suctioning of nasal and oral secretions promotes fluid clearance. Auscultation of lung sounds to assess for any abnormalities. Pulse oximetry is performed to determine oxygen saturation. Monitor signs of respiratory distress such as: nasal flaring, grunting, central cyanosis.<sup id="cite_ref-Lowdermilk_1-6" class="reference"><a href="#cite_note-Lowdermilk-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Metabolic">Metabolic</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adaptation_to_extrauterine_life&action=edit&section=3" title="Edit section: Metabolic"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Physiology: At birth, the newborn is cut off from the mother's glucose supply and will begin to rely on stored fat for energy. <a href="/wiki/Glycogen" title="Glycogen">Glycogen</a> stores are maximal at term. Within the first hour of life, blood glucose will typically reach its lowest point and then stabilize within 2 to 4 hours, hence <a href="/wiki/Breastfeeding" title="Breastfeeding">breastfeeding</a> is promoted immediately. In cases where feeding is delayed, the neonate can use <a href="/wiki/Lactic_acid" title="Lactic acid">lactate</a>, free-fatty acids, and ketone bodies. </p><p>Manifestations: Normal blood glucose levels range from 40 to 50 mg/dl.<sup id="cite_ref-Lowdermilk_1-7" class="reference"><a href="#cite_note-Lowdermilk-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Rooting and sucking reflex should be present and the neonate will eat small amounts frequently. All vital signs should be within normal limits coinciding with the neonates presentation of calmness and satiation. </p><p>Assessments/Interventions: Monitor blood glucose level and encourage breastfeeding or formula feeding as early as possible. Lactation and breastfeeding education should be provided as appropriate. </p> <div class="mw-heading mw-heading2"><h2 id="Temperature_regulation">Temperature regulation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adaptation_to_extrauterine_life&action=edit&section=4" title="Edit section: Temperature regulation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Physiology: Newborns lack the ability of thermogenesis due to underdeveloped shivering mechanism. Body heat is lost through conduction, convection, and radiant heat.<sup id="cite_ref-Lowdermilk_1-8" class="reference"><a href="#cite_note-Lowdermilk-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Thermoregulation is achieved through several methods: the metabolism of brown fat and Kangaroo care, also known as skin to skin. <a href="/wiki/Brown_adipose_tissue" title="Brown adipose tissue">"Brown fat"</a> is specialized adipose tissue with a high concentration of mitochondria designed to rapidly oxidize fatty acids in order to generate metabolic heat.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="removed citation to predatory publisher content (December 2019)">citation needed</span></a></i>]</sup> Skin to skin to care is the immediate placement of the neonate directly onto a caregiver's bare chest. This promotes thermoregulation of the neonate through heat generated from caregiver. </p><p>Manifestations: Normal temperature ranges from 97.7 to 100.0 °F (36.5 to 37.8 °C). Cold infants may cry or appear restless. The neonates' arms and legs maintain a fetal position, lessening their body surface area and reducing heat loss.<sup id="cite_ref-Lowdermilk_1-9" class="reference"><a href="#cite_note-Lowdermilk-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>Assessments/Interventions: Dry neonate immediately after birth and initiate skin-to-skin contact. Provide warm blankets and a hat. Utilize a radiant warmer if skin-to-skin is not appropriate. Frequently monitor axillary body temperature. Limit neonate's exposure during diaper changes and assessments. </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adaptation_to_extrauterine_life&action=edit&section=5" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Shock_of_birth" title="Shock of birth">Shock of birth</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Adaptation_to_extrauterine_life&action=edit&section=6" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-Lowdermilk-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-Lowdermilk_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Lowdermilk_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Lowdermilk_1-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Lowdermilk_1-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Lowdermilk_1-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-Lowdermilk_1-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-Lowdermilk_1-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-Lowdermilk_1-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-Lowdermilk_1-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-Lowdermilk_1-9"><sup><i><b>j</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFLowdermilk._D.Perry,_S._E.Cashion,_K.Alden,_K.R.2016" class="citation book cs1">Lowdermilk. D.; Perry, S. E.; Cashion, K.; Alden, K.R. (2016). <i>Maternity & Women's Health Care</i>. St. Louis: Mosby.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Maternity+%26+Women%27s+Health+Care&rft.place=St.+Louis&rft.pub=Mosby&rft.date=2016&rft.au=Lowdermilk.+D.&rft.au=Perry%2C+S.+E.&rft.au=Cashion%2C+K.&rft.au=Alden%2C+K.R.&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAdaptation+to+extrauterine+life" class="Z3988"></span></span> </li> <li id="cite_note-Morton-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-Morton_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMortonBrodsky2016" class="citation journal cs1">Morton, Sarah U.; Brodsky, Dara (September 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987541">"Fetal Physiology and the Transition to Extrauterine Life"</a>. <i>Clinics in Perinatology</i>. <b>43</b> (3): 395–407. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.clp.2016.04.001">10.1016/j.clp.2016.04.001</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987541">4987541</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27524443">27524443</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Clinics+in+Perinatology&rft.atitle=Fetal+Physiology+and+the+Transition+to+Extrauterine+Life&rft.volume=43&rft.issue=3&rft.pages=395-407&rft.date=2016-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4987541%23id-name%3DPMC&rft_id=info%3Apmid%2F27524443&rft_id=info%3Adoi%2F10.1016%2Fj.clp.2016.04.001&rft.aulast=Morton&rft.aufirst=Sarah+U.&rft.au=Brodsky%2C+Dara&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4987541&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAdaptation+to+extrauterine+life" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAnderson2011" class="citation journal cs1">Anderson, O (15 November 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217058">"Effect of delayed versus early umbilical cord clamping on neonatal outcomes and iron status at 4 months: a randomised controlled trial"</a>. <i>The BMJ</i>. <b>343</b>: d7157. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fbmj.d7157">10.1136/bmj.d7157</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217058">3217058</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22089242">22089242</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+BMJ&rft.atitle=Effect+of+delayed+versus+early+umbilical+cord+clamping+on+neonatal+outcomes+and+iron+status+at+4+months%3A+a+randomised+controlled+trial&rft.volume=343&rft.pages=d7157&rft.date=2011-11-15&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3217058%23id-name%3DPMC&rft_id=info%3Apmid%2F22089242&rft_id=info%3Adoi%2F10.1136%2Fbmj.d7157&rft.aulast=Anderson&rft.aufirst=O&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3217058&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAdaptation+to+extrauterine+life" class="Z3988"></span></span> </li> </ol></div></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist 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href="/wiki/Template:Pregnancy" title="Template:Pregnancy"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Pregnancy" title="Template talk:Pregnancy"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Pregnancy" title="Special:EditPage/Template:Pregnancy"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Pregnancy_and_childbirth" style="font-size:114%;margin:0 4em"><a href="/wiki/Pregnancy" title="Pregnancy">Pregnancy</a> and <a href="/wiki/Childbirth" title="Childbirth">childbirth</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Family_planning" title="Family planning">Planning</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Birth_control" title="Birth control">Birth control</a></li> <li><a href="/wiki/Natural_family_planning" title="Natural family planning">Natural family planning</a></li> <li><a href="/wiki/Male_contraceptive" title="Male contraceptive">Male contraceptive</a></li> <li><a href="/wiki/Pre-conception_counseling" title="Pre-conception counseling">Pre-conception counseling</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Human_fertilization" title="Human fertilization">Conception</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Assisted_reproductive_technology" title="Assisted reproductive technology">Assisted reproductive technology</a> <ul><li><a href="/wiki/Artificial_insemination" title="Artificial insemination">artificial insemination</a></li> <li><a href="/wiki/Fertility_fraud" title="Fertility fraud">fertility fraud</a></li> <li><a href="/wiki/Fertility_medication" title="Fertility medication">fertility medication</a></li> <li><a href="/wiki/In_vitro_fertilisation" title="In vitro fertilisation">in vitro fertilisation</a></li> <li><a href="/wiki/Partner-assisted_reproduction" title="Partner-assisted reproduction">partner-assisted reproduction</a></li></ul></li> <li><a href="/wiki/Fertility_awareness" title="Fertility awareness">Fertility awareness</a></li> <li><a href="/wiki/Unintended_pregnancy" title="Unintended pregnancy">Unintended pregnancy</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Testing</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3D_ultrasound" title="3D ultrasound">3D ultrasound</a></li> <li><a href="/wiki/Obstetric_ultrasonography" title="Obstetric ultrasonography">Obstetric ultrasonography</a></li> <li><a href="/wiki/Pregnancy_test" title="Pregnancy test">Pregnancy test</a> <ul><li><a href="/wiki/HCG_pregnancy_strip_test" class="mw-redirect" title="HCG pregnancy strip test">home testing</a></li></ul></li> <li><a href="/wiki/Prenatal_testing" title="Prenatal testing">Prenatal testing</a></li> <li><a href="/wiki/Medical_imaging_in_pregnancy" title="Medical imaging in pregnancy">Medical imaging</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cervical_pregnancy" title="Cervical pregnancy">Cervical</a></li> <li><a href="/wiki/Cryptic_pregnancy" title="Cryptic pregnancy">Cryptic</a></li> <li><a href="/wiki/Ectopic_pregnancy" title="Ectopic pregnancy">Ectopic</a></li> <li><a href="/wiki/Abdominal_pregnancy" title="Abdominal pregnancy">Abdominal</a></li> <li><a href="/wiki/Heterotopic_pregnancy" title="Heterotopic pregnancy">Heterotopic</a></li> <li><a href="/wiki/Molar_pregnancy" title="Molar pregnancy">Molar</a></li> <li><a href="/wiki/Ovarian_pregnancy" title="Ovarian pregnancy">Ovarian</a></li> <li><a href="/wiki/Postterm_pregnancy" title="Postterm pregnancy">Postterm</a></li> <li><a href="/wiki/Unintended_pregnancy" title="Unintended pregnancy">Unintended</a></li> <li><a href="/wiki/Interstitial_pregnancy" title="Interstitial pregnancy">Interstitial</a></li> <li><a href="/wiki/Rudimentary_horn_pregnancy" title="Rudimentary horn pregnancy">Rudimentary horn</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Childbirth" title="Childbirth">Childbirth</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Preparation</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bradley_method_of_natural_childbirth" title="Bradley method of natural childbirth">Bradley method</a></li> <li><a href="/wiki/Hypnotherapy_in_childbirth" class="mw-redirect" title="Hypnotherapy in childbirth">Hypnobirthing</a></li> <li><a href="/wiki/Lamaze_technique" title="Lamaze technique">Lamaze</a></li> <li><a href="/wiki/Nesting_instinct" title="Nesting instinct">Nesting instinct</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Roles</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mother" title="Mother">Mother</a></li> <li><a href="/wiki/Infant" title="Infant">Newborn</a> <ul><li><a href="/wiki/Preterm_birth" title="Preterm birth">Preterm birth</a></li></ul></li> <li><a href="/wiki/Postterm_pregnancy" title="Postterm pregnancy">Postterm pregnancy</a></li> <li><a href="/wiki/Doula" title="Doula">Doula</a></li> <li><a href="/wiki/Birth_attendant" title="Birth attendant">Birth attendant</a></li> <li><a href="/wiki/Men%27s_role_in_childbirth" title="Men's role in childbirth">Men's roles</a></li> <li><a href="/wiki/Midwife" title="Midwife">Midwife</a> <ul><li><a href="/wiki/Auxiliary_nurse_midwife" title="Auxiliary nurse midwife">Auxiliary nurse midwife</a></li></ul></li> <li><a href="/wiki/Obstetrics_and_gynaecology" title="Obstetrics and gynaecology">Obstetrician</a></li> <li><a href="/wiki/Obstetrical_nursing" title="Obstetrical nursing">Perinatal nurse</a></li> <li><a href="/wiki/Traditional_birth_attendant" title="Traditional birth attendant">Traditional birth attendant</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Delivery</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pelvimetry" title="Pelvimetry">Pelvimetry</a> / <a href="/wiki/Bishop_score" title="Bishop score">Bishop score</a> <ul><li><a href="/wiki/Cervical_dilation" title="Cervical dilation">cervical dilation</a></li> <li><a href="/wiki/Cervical_effacement" title="Cervical effacement">cervical effacement</a></li> <li><a href="/wiki/Position_(obstetrics)" title="Position (obstetrics)">position</a></li></ul></li> <li><a href="/wiki/Bloody_show" title="Bloody show">Bloody show</a></li> <li><a href="/wiki/Uterine_contraction" title="Uterine contraction">Uterine contraction</a></li> <li><a href="/wiki/Vaginal_delivery" title="Vaginal delivery">Vaginal delivery</a></li> <li><a href="/wiki/Presentation_(obstetrics)" title="Presentation (obstetrics)">Presentation</a> <ul><li><a href="/wiki/Breech_birth" title="Breech birth">breech</a></li> <li><a href="/wiki/Cephalic_presentation" title="Cephalic presentation">cephalic</a></li> <li><a href="/wiki/Shoulder_presentation" title="Shoulder presentation">shoulder</a></li></ul></li> <li><a href="/wiki/Rupture_of_membranes" title="Rupture of membranes">Rupture of membranes</a></li> <li><a href="/wiki/Caesarean_section" title="Caesarean section">Caesarean</a></li> <li><a href="/wiki/Childbirth_positions" title="Childbirth positions">Childbirth positions</a></li> <li><a href="/wiki/Home_birth" title="Home birth">Home birth</a></li> <li><a href="/wiki/Labor_induction" title="Labor induction">Labor induction</a></li> <li><a href="/wiki/Multiple_birth" title="Multiple birth">Multiple birth</a></li> <li><a href="/wiki/Natural_childbirth" title="Natural childbirth">Natural childbirth</a></li> <li><a href="/wiki/Silent_birth" title="Silent birth">Silent birth</a></li> <li><a href="/wiki/Unassisted_childbirth" title="Unassisted childbirth">Unassisted childbirth</a></li> <li><a href="/wiki/Water_birth" title="Water birth">Water birth</a></li> <li><a href="/wiki/Placental_expulsion" title="Placental expulsion">Placental expulsion</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Prenatal</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Anatomy</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amniotic_fluid" title="Amniotic fluid">Amniotic fluid</a></li> <li><a href="/wiki/Amniotic_sac" title="Amniotic sac">Amniotic sac</a></li> <li><a href="/wiki/Endometrium" title="Endometrium">Endometrium</a></li> <li><a href="/wiki/Placenta" title="Placenta">Placenta</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Prenatal_development" title="Prenatal development">Development</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Human_embryonic_development" title="Human embryonic development">Embryo</a></li> <li><a href="/wiki/Fetus" title="Fetus">Fetus</a></li> <li><a href="/wiki/Fundal_height" title="Fundal height">Fundal height</a></li> <li><a href="/wiki/Gestational_age" title="Gestational age">Gestational age</a></li> <li><a href="/wiki/Maternal_physiological_changes_in_pregnancy" title="Maternal physiological changes in pregnancy">Maternal physiological changes</a></li> <li><a href="/wiki/Postpartum_physiological_changes" title="Postpartum physiological changes">Postpartum physiological changes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Prenatal_care" title="Prenatal care">Care</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Brain_health_and_pollution" title="Brain health and pollution">Brain health and pollution</a></li> <li>Nutrition <ul><li><a href="/wiki/Environmental_toxicants_and_fetal_development" title="Environmental toxicants and fetal development">environmental toxicants</a></li> <li><a href="/wiki/Nutrition_and_pregnancy" title="Nutrition and pregnancy">in pregnancy</a></li> <li><a href="/wiki/Prenatal_nutrition" title="Prenatal nutrition">prenatal</a></li></ul></li> <li><a href="/wiki/Antenatal_depression" title="Antenatal depression">Prenatal depression</a></li> <li><a href="/wiki/Immunization_during_pregnancy" title="Immunization during pregnancy">Immunization</a></li> <li>Concomitant conditions <ul><li><a href="/wiki/Anemia_in_pregnancy" title="Anemia in pregnancy">Anemia</a></li> <li><a href="/wiki/Hypertensive_disease_of_pregnancy" title="Hypertensive disease of pregnancy">Hypertension</a></li> <li><a href="/wiki/Hypercoagulability_in_pregnancy" title="Hypercoagulability in pregnancy">Hypercoagulability</a></li> <li><a href="/wiki/Drugs_in_pregnancy" title="Drugs in pregnancy">Substance use</a> <ul><li><a href="/wiki/Smoking_and_pregnancy" title="Smoking and pregnancy">Smoking</a></li> <li><a href="/wiki/Alcohol_and_pregnancy" class="mw-redirect" title="Alcohol and pregnancy">Alcohol</a></li> <li><a href="/wiki/Cannabis_in_pregnancy" title="Cannabis in pregnancy">Cannabis</a></li> <li><a href="/wiki/Opioids_and_pregnancy" title="Opioids and pregnancy">Opioids</a></li></ul></li> <li>Endocrine diseases <ul><li><a href="/wiki/Diabetes_and_pregnancy" title="Diabetes and pregnancy">Diabetes</a></li> <li><a href="/wiki/Thyroid_disease_in_pregnancy" title="Thyroid disease in pregnancy">Thyroid disease</a></li></ul></li> <li>Liver diseases <ul><li><a href="/wiki/Acute_fatty_liver_of_pregnancy" title="Acute fatty liver of pregnancy">Acute fatty liver</a></li> <li><a href="/wiki/Intrahepatic_cholestasis_of_pregnancy" title="Intrahepatic cholestasis of pregnancy">Intrahepatic cholestasis</a></li></ul></li> <li>Infections <ul><li><a href="/wiki/HIV_and_pregnancy" title="HIV and pregnancy">HIV</a></li> <li><a href="/wiki/COVID-19_in_pregnancy" title="COVID-19 in pregnancy">COVID-19</a></li> <li><a href="/wiki/HCV_in_children_and_pregnancy" title="HCV in children and pregnancy">Hepatitis C</a></li> <li><a href="/wiki/Pregnancy-associated_malaria" title="Pregnancy-associated malaria">Malaria</a></li></ul></li> <li>Skin diseases <ul><li><a href="/wiki/Lupus_and_pregnancy" title="Lupus and pregnancy">Lupus</a></li> <li><a href="/wiki/Pruritic_folliculitis_of_pregnancy" title="Pruritic folliculitis of pregnancy">Pruritic folliculitis</a></li> <li><a href="/wiki/Dermatoses_of_pregnancy" title="Dermatoses of pregnancy">Dermatoses</a></li></ul></li> <li>Others <ul><li><a href="/wiki/Drugs_in_pregnancy" title="Drugs in pregnancy">Drugs</a></li> <li><a href="/wiki/Vaginal_flora_in_pregnancy" title="Vaginal flora in pregnancy">Vaginal flora</a></li> <li><a href="/wiki/Obstetrical_bleeding" title="Obstetrical bleeding">Bleeding</a></li> <li><a href="/wiki/Motor_vehicle_emissions_and_pregnancy" class="mw-redirect" title="Motor vehicle emissions and pregnancy">Motor vehicle emissions</a></li> <li><a href="/wiki/Pre-existing_disease_in_pregnancy" title="Pre-existing disease in pregnancy">Pre-existing disease</a></li> <li><a href="/wiki/Pregnancy_and_sleep" title="Pregnancy and sleep">Sleep</a></li></ul></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Procedures</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amniocentesis" title="Amniocentesis">Amniocentesis</a></li> <li><a href="/wiki/Cardiotocography" title="Cardiotocography">Cardiotocography</a></li> <li><a href="/wiki/Chorionic_villus_sampling" title="Chorionic villus sampling">Chorionic villus sampling</a></li> <li><a href="/wiki/Nonstress_test" title="Nonstress test">Nonstress test</a></li> <li><a href="/wiki/Abortion" title="Abortion">Abortion</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Postpartum_period" title="Postpartum period">Postpartum</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Maternal</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lochia" title="Lochia">Lochia</a></li> <li><a href="/wiki/Postpartum_care" title="Postpartum care">Postpartum care</a></li> <li><a href="/wiki/Postpartum_depression" title="Postpartum depression">Postpartum depression</a></li> <li><a href="/wiki/Postpartum_confinement" title="Postpartum confinement">Postpartum confinement</a></li> <li><a href="/wiki/Sex_after_pregnancy" title="Sex after pregnancy">Sex after pregnancy</a></li> <li><a href="/wiki/Psychiatric_disorders_of_childbirth" title="Psychiatric disorders of childbirth">Psychiatric disorders of childbirth</a></li> <li><a href="/wiki/Postpartum_physiological_changes" title="Postpartum physiological changes">Postpartum physiological changes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Roles</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Doula" title="Doula">Doula</a></li> <li><a href="/wiki/Health_visitor" title="Health visitor">Health visitor</a></li> <li><a href="/wiki/Lactation_consultant" title="Lactation consultant">Lactation consultant</a></li> <li><a href="/wiki/Monthly_nurse" title="Monthly nurse">Monthly nurse</a></li> <li><a href="/wiki/Nanny#Maternity_nurse_/_newborn_care_specialists_/_confinement_nanny" title="Nanny">Confinement nanny</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Infant</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Adaptation to extrauterine life</a></li> <li><a href="/wiki/Apgar_score" title="Apgar score">Apgar score</a></li> <li><a href="/wiki/Child_care" title="Child care">Child care</a></li> <li><a href="/wiki/Birth_defect" title="Birth defect">Congenital disorders</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Obstetric history</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a 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