CINXE.COM

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<img class="img-banner" src="https://acdbio.com/sites/default/files/science-banner.jpg"><h1 class="general-title">Anatomic Pathology Panels</h1><h2 class="banner-sub-title-seo">RNAscope™ Applications</h2></div><div class="content-container container newapplication"><div id="node-137671" class="node node-application node-promoted" about="/science/applications/research-solutions/anatomic-pathology-panels" typeof="sioc:Item foaf:Document"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs application-bxslider" id="myTab"><li><a href="/science/applications/research-solutions/long-non-coding-rna">Long non-coding RNA</a></li><li><a href="/science/applications/research-solutions/single-cell-analysis">Single Cell Analysis</a></li><li><a href="/science/applications/research-solutions/gene-fusions">Gene Fusions</a></li><li><a href="/science/applications/research-solutions/ngsht-transcriptomic-validation-rna-seq">NGS/HT Transcriptomic Validation (RNA-Seq)</a></li><li><a href="/science/applications/research-solutions/circular-rna">Circular RNA</a></li><li class="active"><a href="/science/applications/research-solutions/anatomic-pathology-panels" class="active">Anatomic Pathology Panels</a></li><li><a href="/science/applications/research-solutions/mirna">miRNA</a></li></ul></div><div class="tab-content"><div id="tab0" class="tab-pane fade in active profile"><h1 class="top-profile">Target probe panels for anatomic pathology</h1><div class="sample-image"></div><div class="profile-content application_node_137671"><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p>With our wide portfolio of ready-to-use probes, ACD provides a broad range of high-quality RNAscope probes for your RNA ISH needs in Anatomical Pathology. We have categorized the key RNAscope probes into thirteen Anatomical Pathology panels, based upon most common tumor, tissue and infectious disease types. Each panel includes RNAscope probes designed to enhance assessment and characterization of target markers in the organ-specific disease states. The Anatomical Pathology panels provide labs with the opportunity to add new markers to complement and add additional confirmation to their traditional IHC panels. </p><h2>Why choose RNAscope™ ISH for your panels?</h2><ul><li><p><strong>Unparalleled sensitivity and specificity</strong> - Detect <em>any</em> marker of interest to complement your IHC or DNA ISH, with consistently reliable results</p></li><li><p><strong>Surpass traditional IHC challenges</strong> - Easy validation, omit issues with high background, low signal or suboptimal antibodies</p></li><li><p><strong>Choose your platform</strong> - Optimize your workflow, RNAscope™ ISH probes are available and ready-to-use in both manual and automated formats. RNAscope probes have been developed for full automation on the Leica BOND and Ventana Discovery platforms</p></li><li><p><strong>Intuitive protocol, implemented seamlessly into your workflow</strong> - The RNAscope™ ISH protocol is easy to follow, similar in many steps to IHC and can be transferred to your established staining platform* with ease</p></li></ul><p><span style="font-size: 10px;">*for Leica BOND and Ventana Discovery platforms</span></p><h2>Ease of Data Analysis</h2><div class="data-analysis"><div class="image-desc"><div class="left-image"><img src="/sites/default/files/ease-data.png" /></div><div class="right-desc"><p>RNAscope™ ISH is easy to interpret and quantify, with a single punctate dot representing 1 RNA molecule, unlike scoring with IHC. In this Non-Small Cell Lung Cancer (NSCLC) FFPE sample, each single dot represents a <em>PDL1</em> RNA molecule. Tumor is highly heterogeneous, with low, medium and high regions of expression identified.</p></div></div></div><div class="panel-list"><h2>List of Panel</h2><div class="panel-contents"><div class="solutions-accordion"><div class="solution-tab"><div class="solution-tab-head"><h3>Breast Pathology</h3></div><div class="solution-tab-content"><table><thead><tr><th>Marker</th><th>Probe Name</th></tr></thead><tbody><tr><td>HER2 (ERBB2)</td><td><a href="/search/site/%252AHs-ERBB2%252A/cms/probes">Hs-ERBB2</a></td></tr><tr><td>ER (ESR1)</td><td><a href="/search/site/%252AHs-ESR1%252A/cms/probes">Hs-ESR1</a></td></tr><tr><td>PR (PGR)</td><td><a href="/search/site/%252AHs-PGR%252A/cms/probes">Hs-PGR</a></td></tr><tr><td>GATA3</td><td><a href="/search/site/%252AHs-GATA3%252A/cms/probes">Hs-GATA3</a></td></tr><tr><td>PD-L1 (CD274)</td><td><a href="/search/site/%252AHs-CD274%252A/cms/probes">Hs-CD274</a></td></tr><tr><td>GCDFP15 (PIP)</td><td><a href="/search/site/%252AHs-PIP%252A/cms/probes">Hs-PIP</a></td></tr></tbody></table></div></div><div class="solution-tab"><div class="solution-tab-head"><h3>Cervical Pathology</h3></div><div class="solution-tab-content"><table><thead><tr><th>Marker</th><th>Probe Name</th></tr></thead><tbody><tr><td>HPV 16</td><td><a href="/search/site/%252AHPV16%252A/cms/probes">HPV 16</a></td></tr><tr><td>HPV 18</td><td><a href="/search/site/%252AHPV18%252A/cms/probes">HPV 18</a></td></tr><tr><td>HPV 16/18</td><td><a href="/search/site/%252AHPV16%252f18%252A/cms/probes">HPV 16/18</a></td></tr><tr><td>HPV 6</td><td><a href="/search/site/%252AHPV%206%252A/cms/probes">HPV 6</a></td></tr><tr><td>HPV 11</td><td><a href="/search/site/%252AHPV11%252A/cms/probes">HPV 11</a></td></tr><tr><td>HPV 6/11</td><td><a href="/search/site/%252AHPV6%252f11%252A/cms/probes">HPV 6/11</a></td></tr><tr><td>HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82)</td><td><a href="/search/site/%252AHPV-HR18%252A/cms/probes">HPV HR18</a></td></tr><tr><td>HPV High Risk 7 Pool (16, 18, 31, 33, 35, 52, & 58)</td><td><a href="/search/site/%252AHPV-HR7%252A/cms/probes">HPV HR7</a></td></tr><tr><td>HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44)</td><td><a href="/search/site/%252AHPV%20LR6%252A/cms/probes">HPV LR6</a></td></tr><tr><td>P16 (CDKN2A)</td><td><a href="/search/site/%252AHs-CDKN2A%252A/cms/probes">Hs-CDKN2A</a></td></tr></tbody></table></div></div><div class="solution-tab"><div class="solution-tab-head"><h3>Colorectal Pathology</h3></div><div class="solution-tab-content"><table><thead><tr><th>Marker</th><th>Probe Name</th></tr></thead><tbody><tr><td>EGFR</td><td><a href="/search/site/%252AHs-EGFR%252A/cms/probes">Hs-EGFR</a></td></tr><tr><td>MLH1</td><td><a href="/search/site/%252AHs-MLH1%252A/cms/probes">Hs-MLH1</a></td></tr><tr><td>MSH2</td><td><a href="/search/site/%252AHs-MSH2%252A/cms/probes">Hs-MSH2</a></td></tr><tr><td>MSH6</td><td><a href="/search/site/%252AHs-MSH6%252A/cms/probes">HS-MSH6</a></td></tr><tr><td>PMS2</td><td><a href="/search/site/%252AHs-PMS2-O1%252A/cms/probes">Hs-PMS2-01</a></td></tr><tr><td>PD-L1 (CD274)</td><td><a href="/search/site/%252AHs-CD274%252A/cms/probes">Hs-CD274</a></td></tr></tbody></table></div></div><div class="solution-tab"><div class="solution-tab-head"><h3>Dermatopathology</h3></div><div class="solution-tab-content"><table><thead><tr><th>Marker</th><th>Probe Name</th></tr></thead><tbody><tr><td>Merkel Cell Polyoma Virus</td><td><a href="/search/site/%252AMCPyV%252A/cms/probes">V-MCPyV-LT-ST-Ag</a></td></tr><tr><td>PD-L1 (CD274)</td><td><a href="/search/site/%252AHs-CD274%252A/cms/probes">Hs-CD274</a></td></tr><tr><td>HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82)</td><td><a href="/search/site/%252AHPV-HR18%252A/cms/probes">HPV HR18</a></td></tr><tr><td>HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44)</td><td><a href="/search/site/%252AHPV%20LR6%252A/cms/probes">HPV LR6</a></td></tr></tbody></table></div></div><div class="solution-tab"><div class="solution-tab-head"><h3>Gynecologic Pathology</h3></div><div class="solution-tab-content"><table><thead><tr><th>Marker</th><th>Probe Name</th></tr></thead><tbody><tr><td>PAX8</td><td><a href="/search/site/%252AHS-PAX8%252A/cms/probes">Hs-PAX8</a></td></tr><tr><td>BRCA1</td><td><a href="/search/site/%252AHs-BRCA1%252A/cms/probes">Hs-BRCA1</a></td></tr><tr><td>P53</td><td><a href="/search/site/%252AHs-TP53%252A/cms/probes">Hs-TP53</a></td></tr></tbody></table></div></div><div class="solution-tab"><div class="solution-tab-head"><h3>Head and Neck Pathology</h3></div><div class="solution-tab-content"><table><thead><tr><th>Marker</th><th>Probe Name</th></tr></thead><tbody><tr><td>HPV 16</td><td><a href="/search/site/%252AHPV16%252A/cms/probes">HPV 16</a></td></tr><tr><td>HPV 18</td><td><a href="/search/site/%252AHPV18%252A/cms/probes">HPV 18</a></td></tr><tr><td>HPV 45</td><td><a href="/search/site/%252AHPV45%252A/cms/probes">HPV 45</a></td></tr><tr><td>HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82)</td><td><a href="/search/site/%252AHPV-HR18%252A/cms/probes">HPV HR18</a></td></tr><tr><td>HPV High Risk 7 Pool (16, 18, 31, 33, 35, 52, & 58)</td><td><a href="/search/site/%252AHPV-HR7%252A/cms/probes">HPV HR7</a></td></tr><tr><td>HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44)</td><td><a href="/search/site/%252AHPV%20LR6%252A/cms/probes">HPV LR6</a></td></tr><tr><td>P16 (CDKN2A)</td><td><a href="/search/site/%252AHs-CDKN2A%252A/cms/probes">Hs-CDKN2A</a></td></tr><tr><td>PD-L1 (CD274)</td><td><a href="/search/site/%252AHs-CD274%252A/cms/probes">Hs-CD274</a></td></tr></tbody></table></div></div><div class="solution-tab"><div class="solution-tab-head"><h3>Hematopathology</h3></div><div class="solution-tab-content"><table><thead><tr><th>Marker</th><th>Probe Name</th></tr></thead><tbody><tr><td>EBV</td><td><a href="http://www.leicabiosystems.com/ihc-ish-fish/acd-ish-probes/products/ebv-probe/">EBV EBER-1</a></td></tr><tr><td>Kappa</td><td><a href="/search/site/%252AHs-IGK%252A/cms/probes">Hs-IGK</a></td></tr><tr><td>Lambda</td><td><a href="/search/site/%252AHs-IGL%252A/cms/probes">Hs-IGL</a></td></tr><tr><td>IGLL5</td><td><a href="/search/site/%252AHs-IGLL5%252A/cms/probes">Hs-IGLL5</a></td></tr><tr><td>CXCL13</td><td><a href="/search/site/%252AHs-CXCL13%252A/cms/probes">Hs-CXCL13</a></td></tr><tr><td>IRTA1 (FCRL4)</td><td><a href="/search/site/%252AHs-FCRL4%252A/cms/probes">Hs-FCRL4</a></td></tr><tr><td>PD-L2 (PDCD1LG2)</td><td><a href="/search/site/%252AHs-PDCD1LG2-O1%252A/cms/probes">Hs-PDCD1LG2-01</a></td></tr><tr><td>PD-L1 (CD274)</td><td><a href="/search/site/%252AHs-CD274%252A/cms/probes">Hs-CD274</a></td></tr><tr><td>Annexin A1 (ANXA1)</td><td><a href="/search/site/%252AHS-ANXA1%252A/cms/probes">Hs-ANXA1</a></td></tr><tr><td>Bartonella hensalae</td><td><a href="/search/site/%252AB-B.henselae-23SrRNA%252A/cms/probes">B-B.henselae-23SrRNA</a></td></tr></tbody></table></div></div><div class="solution-tab"><div class="solution-tab-head"><h3>Infectious Disease Pathology</h3></div><div class="solution-tab-content"><table><thead><tr><th>Marker</th><th>Probe Name</th></tr></thead><tbody><tr><td>EBV</td><td><a href="http://www.leicabiosystems.com/ihc-ish-fish/acd-ish-probes/products/ebv-probe/">EBV EBER-1</a></td></tr><tr><td>CMV</td><td><a href="http://www.leicabiosystems.com/ihc-ish-fish/acd-ish-probes/products/cmv-probe-1/">CMV</a></td></tr><tr><td>HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82)</td><td><a href="/search/site/%252AHPV-HR18%252A/cms/probes">HPV HR18</a></td></tr><tr><td>HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44)</td><td><a href="/search/site/%252AHPV%20LR6%252A/cms/probes">HPV LR6</a></td></tr><tr><td>BK Virus</td><td><a href="/search/site/%252A503528%252A/cms/probes">V-BKV</a></td></tr><tr><td>Merkel Cell Polyoma Virus</td><td><a href="/search/site/%252AMCPyV%252A/cms/probes">V-MCPyV-LT-ST-Ag</a></td></tr><tr><td>Zika Virus</td><td><a href="/search/site/%252AV-ZIKA-pp%252A/cms/probes">V-ZIKA-pp</a></td></tr><tr><td>Bartonella hensalae</td><td><a href="/search/site/%252AB-B.henselae-23SrRNA%252A/cms/probes">B-B.henselae-23SrRNA</a></td></tr><tr><td>Mycobacteria tuberculosis (MTB)</td><td><a href="#">B-MTB</a></td></tr><tr><td>Non-tuberculous mycobacteria (NTM)</td><td><a href="/search/site/%252ANTM%252A/cms/probes">B-NTM</a></td></tr></tbody></table></div></div><div class="solution-tab"><div class="solution-tab-head"><h3>Liver Pathology</h3></div><div class="solution-tab-content"><table><thead><tr><th>Marker</th><th>Probe Name</th></tr></thead><tbody><tr><td>Albumin</td><td><a 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576-8798</p></div><div class="row"><p> </p><div class="row"><h3>Bio-Techne</h3><p>19 Barton Lane <br />Abingdon Science Park<br />Abingdon<br />OX14 3NB<br />United Kingdom<br />Phone 2: +44 1235 529449<br />Fax: +44 1235 533420</p><p> </p></div><div class="row"><h3>Advanced Cell Diagnostics China</h3><p>20F, Tower 3,<br />Raffles City Changning Office,<br />1193 Changning Road, Shanghai 200051</p><p>021-52293200<br /><a href="mailto:info.cn@bio-techne.com">info.cn@bio-techne.com</a><br />Web: <a href="http://www.acdbio.com/cn">www.acdbio.com/cn</a></p></div><div class="row"><p>For general information: <a href="mailto:Info.ACD@bio-techne.com">Info.ACD@bio-techne.com</a><br />For place an order: <a href="mailto:order.ACD@bio-techne.com">order.ACD@bio-techne.com</a><br />For product support: <a href="mailto:support.ACD@bio-techne.com">support.ACD@bio-techne.com</a><br />For career opportunities: <a href="mailto:hr.ACD@bio-techne.com">hr.ACD@bio-techne.com</a></p></div></div><div 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