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</nav><nav class="breadcrumb-and-search-bar navbar navbar-expand navbar-light d-print d-flex justify-content-between"> <div><ol class="breadcrumb navbar-text my-0 pl-1" itemscope="itemscope" itemtype="https://schema.org/BreadcrumbList"><li itemprop="itemListElement" itemscope itemtype="https://schema.org/ListItem"> <a href="https://clinicaltrials.ucsf.edu/" itemscope="itemscope" itemprop="item" itemtype="https://schema.org/Thing" id="navbar--breadcrumb--link-1"> Home <meta itemprop="name" content="UCSF Clinical Trials"> </a> <meta itemprop="position" content="1"></li><li itemprop="itemListElement" itemscope itemtype="https://schema.org/ListItem"> <a href="https://clinicaltrials.ucsf.edu/neuroblastoma" itemscope="itemscope" itemprop="item" itemtype="https://schema.org/Thing" aria-description="See all trials related to Neuroblastoma" id="navbar--breadcrumb--link-2"> <span itemprop="name">Neuroblastoma</span> Studies </a> <meta itemprop="position" content="2"></li><li class="active">This trial</li></ol></div> <div><div class="d-none d-md-block navbar-text"><form method="GET" action="https://clinicaltrials.ucsf.edu/" class="form-inline my-1" role="search"> <label class="sr-only" for="header-search--input">Search</label> <input id="header-search--input" name="q" type="text" class="form-control form-control-sm" placeholder="Search UCSF clinical trials" title="Search clinical trials at UCSF"> <input class="sr-only form-control-sm btn btn-sm btn-secondary" type="submit" value="Search trials"> </form></div></div> </nav></header><main id="content" class="mx-1 mx-md-0"> <div class="container-xl px-5"><div class="row"><div class="col-md-9 col-lg-8" role="main" id="main-column"><div id="summary" class="page-header show-jargon-definitions"><div class="h3 alert alert-danger text-center">This study is in progress, not accepting new patients</div><h1 id="summary--title"> A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma </h1><p class="h3 hide-long-content">a study on <span class="comma-list"><span class="comma-list-item"> <a href="../neuroblastoma">Neuroblastoma</a></span></span></p></div><div id="trial-details-container"><div id="key-points" class="trial-details-block"><div class="row"> <div class="col"><h2 class="sr-only h3">Summary</h2><dl id="key-points-bullets" class="row"><dt class="d-none d-sm-block col-sm-1 col-lg-2"> <i class="fa fa-user fa-lg fa-fw" aria-hidden="true"></i> <span class="sr-only">Eligibility</span></dt><dd class="col-12 col-sm-11 col-lg-10"> <strong>for people ages 2-21</strong> (<a href="#eligibility">full criteria</a>) </dd><dt class="d-none d-sm-block col-sm-1 col-lg-2"> <i class="fa fa-map-marker fa-lg fa-fw" aria-hidden="true"></i> <span class="sr-only">Location</span></dt><dd class="col-12 col-sm-11 col-lg-10"> <a href="#location"> at San Francisco, California and other locations </a> </dd><dt class="d-none d-sm-block col-sm-1 col-lg-2"> <i class="fa fa-calendar fa-lg fa-fw" aria-hidden="true"></i> <span class="sr-only">Dates</span></dt><dd class="col-12 col-sm-11 col-lg-10"><div> study started <span itemscope itemtype="https://schema.org/WebPage"><time itemprop="dateCreated" datetime="2020-06-11">June 2020</time></span></div><div> completion around <time datetime="2025-08-31">August 2025</time></div><div itemscope itemtype="https://schema.org/WebPage" aria-hidden="true" class="d-none"><meta itemprop="datePublished" content="2019-09-26"></div></dd></dl></div> </div></div><div id="description" class="trial-details-block"><h2 class="h3">Description</h2><div class="show-jargon-definitions"><h3 class="h4">Summary</h3><div class="hide-long-content"><p>The reason for this study is to see if the study drug LY3295668 erbumine is safe in participants with relapsed/refractory <a href="../neuroblastoma" class="trial--link-to-condition-in-text">neuroblastoma</a>.</p></div><h3 class="h4">Official Title</h3><p class="hide-long-content">A Phase 1 Study of Aurora Kinase A Inhibitor LY3295668 Erbumine as a Single Agent and in Combination in Patients With Relapsed/Refractory Neuroblastoma</p><h3 class="h4">Keywords</h3><p class=" hide-long-content"><span> <a href="../neuroblastoma" class="trial--link-to-condition-in-text">Neuroblastoma</a></span>, <span> aurora kinase A</span>, <span> kinase</span>, <span> aurora A</span>, <span> aurora kinase inhibitor</span>, <span> aurora kinase A inhibitor</span>, <span> kinase inhibitor</span>, <span> AURKA</span>, <span> AurA</span>, <span> pediatric neuroblastoma</span>, <span> children</span>, <span> Cyclophosphamide</span>, <span> Topotecan</span>, <span> LY3295668 Erbumine</span>, <span> LY3295668 Erbumine Escalation</span>, <span> LY3295668 Erbumine + Topotecan + Cyclophosphamide Escalation</span>, <span> LY3295668 Erbumine Expansion</span>, <span> LY3295668 Erbumine + Topotecan + Cyclophosphamide Expansion</span></p></div></div><div id="eligibility" class="trial-details-block show-jargon-definitions"><h2 class="h3">Eligibility</h2><div class="hide-long-content"><div class="row"><div class="col-12 col-lg-6"><h3 class="h4 mt-0"> <i class="fa fa-check-square-o" aria-hidden="true"></i> You can join if… </h3><div><p><strong>Open to people ages 2-21</strong></p><ul><li>Participants must have relapsed/refractory <a href="../neuroblastoma" class="trial--link-to-condition-in-text">neuroblastoma</a> and have active disease in at least one site: bone, bone marrow or soft tissue. Participants must be able to submit an archival sample of tissue.</li><li>Participants must be able to swallow capsules.</li></ul></div></div><div class="col-12 col-lg-6"><h3 class="h4 mt-0"> <i class="fa fa-ban" aria-hidden="true"></i> You CAN'T join if... </h3><div><ul><li>Participants must not have had an <a href="../allogeneic-hematopoietic-cell" class="trial--link-to-condition-in-text">allogeneic hematopoietic stem cell</a>, bone marrow, or solid organ transplant.</li><li>Participants must not have untreated tumor that has spread to the brain or spinal cord.</li><li>Participants must not have a serious active disease other than <a href="../neuroblastoma" class="trial--link-to-condition-in-text">neuroblastoma</a>.</li><li>Participants must not have a condition affecting absorption.</li><li>Participants must not have had prior aurora kinase inhibitor exposure.</li><li>Participants must not have a known allergy to the study treatment.</li><li>Participants must not have symptomatic human immunodeficiency virus (HIV) infection or symptomatic activated/reactivated <a href="../hepatitis-a" class="trial--link-to-condition-in-text">hepatitis A</a>, B, or C.</li></ul></div></div></div></div></div><div id="location" class="trial-details-block"><h2 class="h3">Locations</h2><ul id="locations-list" class="hide-long-content "><li class="location location-is-institutional" itemprop="address" itemscope itemtype="https://schema.org/PostalAddress"><span class="location-name" itemprop="name">UCSF Medical Center at Mission Bay</span><br><span class="location-address comma-list comma-list--without-and"><span class="comma-list-item" itemprop="addressLocality"> San Francisco</span><span class="comma-list-item" itemprop="addressRegion"> California</span><span class="comma-list-item" itemprop="postalCode"> 94158</span><span class="comma-list-item" itemprop="addressCountry"> United States</span></span></li><li class="location " itemprop="address" itemscope itemtype="https://schema.org/PostalAddress"><span class="location-name" itemprop="name">Children's Hospital Colorado</span><br><span class="location-address comma-list comma-list--without-and"><span class="comma-list-item" itemprop="addressLocality"> Aurora</span><span class="comma-list-item" itemprop="addressRegion"> Colorado</span><span class="comma-list-item" itemprop="postalCode"> 80045</span><span class="comma-list-item" itemprop="addressCountry"> United States</span></span></li></ul></div><div id="details" class="trial-details-block"><h2 class="h3">Details</h2><dl class="row"><dt class="col-sm-3 text-sm-right">Status</dt><dd class="col-sm-9"> in progress, not accepting new patients </dd><dt class="col-sm-3 text-sm-right">Start Date</dt><dd class="col-sm-9"><time datetime="2020-06-11">June 2020</time></dd><dt class="col-sm-3 text-sm-right">Completion Date</dt><dd class="col-sm-9"><time datetime="2025-08-31">August 2025</time> (estimated)</dd><dt class="col-sm-3 text-sm-right">Sponsor</dt><dd class="col-sm-9">Eli Lilly and Company</dd><dt class="col-sm-3 text-sm-right">Links</dt><dd class="col-sm-9"> <a href="https://trials.lillytrialguide.com/en-US/trial/50gRHl2d9N02mw6yfhdI4Z" class="trial--link-to-external-study-link d-block" target="_blank" rel="noopener ugc nofollow"><i class="fa fa-link" aria-hidden="true"></i> A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma</a> </dd><dt class="col-sm-3 text-sm-right">ID</dt><dd class="col-sm-9"> <a href="https://clinicaltrials.gov/ct2/show/NCT04106219" class="trial--link-to-clinicaltrials-gov" target="_blank" rel="noopener nofollow" title="ClinicalTrials.gov identifier">NCT04106219</a> </dd><dt class="col-sm-3 text-sm-right">Phase</dt><dd class="col-sm-9">Phase 1 Neuroblastoma Research Study</dd><dt class="col-sm-3 text-sm-right">Study Type</dt><dd class="col-sm-9">Interventional</dd><dt class="col-sm-3 text-sm-right">Participants</dt><dd class="col-sm-9">Expecting 71 study participants</dd><dt class="col-sm-3 text-sm-right">Last Updated</dt><dd class="col-sm-9"><span itemscope itemtype="https://schema.org/WebPage"><time itemprop="dateModified" datetime="2024-08-27">August 27, 2024</time></span></dd></dl></div><div id="faq" class="trial-details-block d-print-none" role="complementary"><h2 class="h3">Frequently Asked Questions</h2><ul><li><a href="../about/how-clinical-trials-work">How Do Clinical Trials Work?</a></li><li><a href="../about/what-to-expect">What to Expect</a></li><li><a href="../about/who-can-join">Who Can Join</a></li><li><a href="../about/our-researchers">Our Researchers</a></li></ul></div></div> </div><div class="col-md-3 text-center offset-lg-1 d-none d-md-block d-print-none" id="secondary-column"> <div id="sidebar"></div> </div></div> </div> <script type="application/ld+json"> [{"@context":"https://schema.org/","@type":"MedicalTrial","additionalType":"Product","alternateName":"A Phase 1 Study of Aurora Kinase A Inhibitor 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