Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: KEYNOTE-164

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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="M1WSqUPknm6HVv3vrHj1fN49bCKkh40uks5hjRUYY1no6aS9SBLScjTX4Arzk7Rq"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="M1WSqUPknm6HVv3vrHj1fN49bCKkh40uks5hjRUYY1no6aS9SBLScjTX4Arzk7Rq"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="M1WSqUPknm6HVv3vrHj1fN49bCKkh40uks5hjRUYY1no6aS9SBLScjTX4Arzk7Rq"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="M1WSqUPknm6HVv3vrHj1fN49bCKkh40uks5hjRUYY1no6aS9SBLScjTX4Arzk7Rq"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="31725351"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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name="csrfmiddlewaretoken" value="M1WSqUPknm6HVv3vrHj1fN49bCKkh40uks5hjRUYY1no6aS9SBLScjTX4Arzk7Rq"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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class="heading" id="heading"> <div class="full-view" id="full-view-heading"> <div class="article-citation"> <div class="publication-type" >Clinical Trial</div> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="full-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Journal of clinical oncology : official journal of the American Society of Clinical Oncology" tabindex="0" aria-controls="full-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Journal of clinical oncology : official journal of the American Society of Clinical Oncology" data-pinger-ignore> J Clin Oncol </button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Journal of clinical oncology : official journal of the American Society of Clinical Oncology"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22J+Clin+Oncol%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22J+Clin+Oncol%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=J Clin Oncol" data-ga-category="search" data-ga-action="journal_link" data-ga-label="J Clin Oncol"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Clin+Oncol%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="J Clin Oncol"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"J Clin Oncol"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"J Clin Oncol"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2020 Jan 1;38(1):11-19.</span> </div> <span class="citation-doi"> doi: 10.1200/JCO.19.02107. </span> <span class="secondary-date"> Epub 2019 Nov 14. </span> </div> <h1 class="heading-title"> Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: KEYNOTE-164 </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Le+DT&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dung T Le">Dung T Le</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kim+TW&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tae Won Kim">Tae Won Kim</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Asan Medical Center, Seoul, Republic of Korea." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Van+Cutsem+E&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Eric Van Cutsem">Eric Van Cutsem</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University Hospitals Gasthuisberg Leuven, KU Leuven, Leuven, Belgium." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Geva+R&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ravit Geva">Ravit Geva</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Tel Aviv Sourasky Medical Center, Tel Aviv, Israel." href="#full-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=J%C3%A4ger+D&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dirk Jäger">Dirk Jäger</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Nationales Centrum Tumorerkrankungen, Heidelberg, Germany." href="#full-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Hara+H&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hiroki Hara">Hiroki Hara</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Saitama Cancer Center, Saitama, Japan." href="#full-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Burge+M&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Matthew Burge">Matthew Burge</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Royal Brisbane and Women's Hospital, Herston, QLD, Australia." href="#full-view-affiliation-7" ref="linksrc=author_aff"> 7 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=O%27Neil+B&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bert O'Neil">Bert O'Neil</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Indiana University Health University Hospital, Indianapolis, IN." href="#full-view-affiliation-8" ref="linksrc=author_aff"> 8 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kavan+P&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Petr Kavan">Petr Kavan</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="McGill University Health Centre, Montréal, Québec, Canada." href="#full-view-affiliation-9" ref="linksrc=author_aff"> 9 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yoshino+T&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Takayuki Yoshino">Takayuki Yoshino</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="National Cancer Center Hospital East, Chiba, Japan." href="#full-view-affiliation-10" ref="linksrc=author_aff"> 10 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Guimbaud+R&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rosine Guimbaud">Rosine Guimbaud</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Centre Hospitalier Universitaire de Toulouse, Toulouse, France." href="#full-view-affiliation-11" ref="linksrc=author_aff"> 11 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Taniguchi+H&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hiroya Taniguchi">Hiroya Taniguchi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Aichi Cancer Center Hospital, Aichi, Japan." href="#full-view-affiliation-12" ref="linksrc=author_aff"> 12 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Elez+E&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Elena Elez">Elena Elez</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Vall d'Hebron Institute of Oncology, Barcelona, Spain." href="#full-view-affiliation-13" ref="linksrc=author_aff"> 13 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Al-Batran+SE&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Salah-Eddin Al-Batran">Salah-Eddin Al-Batran</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Krankenhaus Nordwest, Frankfurt, Germany." href="#full-view-affiliation-14" ref="linksrc=author_aff"> 14 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Boland+PM&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Patrick M Boland">Patrick M Boland</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Roswell Park Comprehensive Cancer Center, Buffalo, NY." href="#full-view-affiliation-15" ref="linksrc=author_aff"> 15 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Crocenzi+T&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Todd Crocenzi">Todd Crocenzi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Providence Cancer Center, Portland, OR." href="#full-view-affiliation-16" ref="linksrc=author_aff"> 16 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Atreya+CE&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Chloe E Atreya">Chloe E Atreya</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA." href="#full-view-affiliation-17" ref="linksrc=author_aff"> 17 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Cui+Y&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yi Cui">Yi Cui</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="MSD China, Beijing, People's Republic of China." href="#full-view-affiliation-18" ref="linksrc=author_aff"> 18 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Dai+T&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tong Dai">Tong Dai</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Merck & Co Inc, Kenilworth, NJ." href="#full-view-affiliation-19" ref="linksrc=author_aff"> 19 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Marinello+P&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Patricia Marinello">Patricia Marinello</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Merck & Co Inc, Kenilworth, NJ." href="#full-view-affiliation-19" ref="linksrc=author_aff"> 19 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Diaz+LA+Jr&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Luis A Diaz Jr">Luis A Diaz Jr</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Memorial Sloan Kettering Cancer Center, New York, NY." href="#full-view-affiliation-20" ref="linksrc=author_aff"> 20 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Andr%C3%A9+T&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Thierry André">Thierry André</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Sorbonne Université, Paris, France." href="#full-view-affiliation-21" ref="linksrc=author_aff"> 21 </a></sup></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/31725351/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.</li> <li data-affiliation-id="full-view-affiliation-2" id="full-view-affiliation-2" ><sup class="key">2</sup> Asan Medical Center, Seoul, Republic of Korea.</li> <li data-affiliation-id="full-view-affiliation-3" id="full-view-affiliation-3" ><sup class="key">3</sup> University Hospitals Gasthuisberg Leuven, KU Leuven, Leuven, Belgium.</li> <li data-affiliation-id="full-view-affiliation-4" id="full-view-affiliation-4" ><sup class="key">4</sup> Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.</li> <li data-affiliation-id="full-view-affiliation-5" id="full-view-affiliation-5" ><sup class="key">5</sup> Nationales Centrum Tumorerkrankungen, Heidelberg, Germany.</li> <li data-affiliation-id="full-view-affiliation-6" id="full-view-affiliation-6" ><sup class="key">6</sup> Saitama Cancer Center, Saitama, Japan.</li> <li data-affiliation-id="full-view-affiliation-7" id="full-view-affiliation-7" ><sup class="key">7</sup> Royal Brisbane and Women's Hospital, Herston, QLD, Australia.</li> <li data-affiliation-id="full-view-affiliation-8" id="full-view-affiliation-8" ><sup class="key">8</sup> Indiana University Health University Hospital, Indianapolis, IN.</li> <li data-affiliation-id="full-view-affiliation-9" id="full-view-affiliation-9" ><sup class="key">9</sup> McGill University Health Centre, Montréal, Québec, Canada.</li> <li data-affiliation-id="full-view-affiliation-10" id="full-view-affiliation-10" ><sup class="key">10</sup> National Cancer Center Hospital East, Chiba, Japan.</li> <li data-affiliation-id="full-view-affiliation-11" id="full-view-affiliation-11" ><sup class="key">11</sup> Centre Hospitalier Universitaire de Toulouse, Toulouse, France.</li> <li data-affiliation-id="full-view-affiliation-12" id="full-view-affiliation-12" ><sup class="key">12</sup> Aichi Cancer Center Hospital, Aichi, Japan.</li> <li data-affiliation-id="full-view-affiliation-13" id="full-view-affiliation-13" ><sup class="key">13</sup> Vall d'Hebron Institute of Oncology, Barcelona, Spain.</li> <li data-affiliation-id="full-view-affiliation-14" id="full-view-affiliation-14" ><sup class="key">14</sup> Krankenhaus Nordwest, Frankfurt, Germany.</li> <li data-affiliation-id="full-view-affiliation-15" id="full-view-affiliation-15" ><sup class="key">15</sup> Roswell Park Comprehensive Cancer Center, Buffalo, NY.</li> <li data-affiliation-id="full-view-affiliation-16" id="full-view-affiliation-16" ><sup class="key">16</sup> Providence Cancer Center, Portland, OR.</li> <li data-affiliation-id="full-view-affiliation-17" id="full-view-affiliation-17" ><sup class="key">17</sup> University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.</li> <li data-affiliation-id="full-view-affiliation-18" id="full-view-affiliation-18" ><sup class="key">18</sup> MSD China, Beijing, People's Republic of China.</li> <li data-affiliation-id="full-view-affiliation-19" id="full-view-affiliation-19" ><sup class="key">19</sup> Merck & Co Inc, Kenilworth, NJ.</li> <li data-affiliation-id="full-view-affiliation-20" id="full-view-affiliation-20" ><sup class="key">20</sup> Memorial Sloan Kettering Cancer Center, New York, NY.</li> <li data-affiliation-id="full-view-affiliation-21" id="full-view-affiliation-21" ><sup class="key">21</sup> Sorbonne Université, Paris, France.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">31725351</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC7031958&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7031958/" data-ga-category="full_text" data-ga-action="PMCID" > PMC7031958 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1200/JCO.19.02107&id_type=DOI" href="https://doi.org/10.1200/jco.19.02107" data-ga-category="full_text" data-ga-action="DOI" > 10.1200/JCO.19.02107 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <div class="publication-type" >Clinical Trial</div> <h1 class="heading-title"> Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: KEYNOTE-164 </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Dung T Le</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> J Clin Oncol<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2020">2020</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/31725351/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change 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aria-controls="short-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Journal of clinical oncology : official journal of the American Society of Clinical Oncology" data-pinger-ignore> J Clin Oncol </button><div id="short-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Journal of clinical oncology : official journal of the American Society of Clinical Oncology"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22J+Clin+Oncol%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22J+Clin+Oncol%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=J Clin Oncol" data-ga-category="search" data-ga-action="journal_link" data-ga-label="J Clin Oncol"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Clin+Oncol%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="J Clin Oncol"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"J Clin Oncol"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"J Clin Oncol"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2020 Jan 1;38(1):11-19.</span> </div> <span class="citation-doi"> doi: 10.1200/JCO.19.02107. </span> <span class="secondary-date"> Epub 2019 Nov 14. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Le+DT&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dung T Le">Dung T Le</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kim+TW&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tae Won Kim">Tae Won Kim</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Asan Medical Center, Seoul, Republic of Korea." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Van+Cutsem+E&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Eric Van Cutsem">Eric Van Cutsem</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University Hospitals Gasthuisberg Leuven, KU Leuven, Leuven, Belgium." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Geva+R&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ravit Geva">Ravit Geva</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Tel Aviv Sourasky Medical Center, Tel Aviv, Israel." href="#short-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=J%C3%A4ger+D&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dirk Jäger">Dirk Jäger</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Nationales Centrum Tumorerkrankungen, Heidelberg, Germany." href="#short-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Hara+H&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hiroki Hara">Hiroki Hara</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Saitama Cancer Center, Saitama, Japan." href="#short-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Burge+M&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Matthew Burge">Matthew Burge</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Royal Brisbane and Women's Hospital, Herston, QLD, Australia." href="#short-view-affiliation-7" ref="linksrc=author_aff"> 7 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=O%27Neil+B&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bert O'Neil">Bert O'Neil</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Indiana University Health University Hospital, Indianapolis, IN." href="#short-view-affiliation-8" ref="linksrc=author_aff"> 8 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kavan+P&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Petr Kavan">Petr Kavan</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="McGill University Health Centre, Montréal, Québec, Canada." href="#short-view-affiliation-9" ref="linksrc=author_aff"> 9 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yoshino+T&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Takayuki Yoshino">Takayuki Yoshino</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="National Cancer Center Hospital East, Chiba, Japan." href="#short-view-affiliation-10" ref="linksrc=author_aff"> 10 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Guimbaud+R&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rosine Guimbaud">Rosine Guimbaud</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Centre Hospitalier Universitaire de Toulouse, Toulouse, France." href="#short-view-affiliation-11" ref="linksrc=author_aff"> 11 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Taniguchi+H&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hiroya Taniguchi">Hiroya Taniguchi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Aichi Cancer Center Hospital, Aichi, Japan." href="#short-view-affiliation-12" ref="linksrc=author_aff"> 12 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Elez+E&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Elena Elez">Elena Elez</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Vall d'Hebron Institute of Oncology, Barcelona, Spain." href="#short-view-affiliation-13" ref="linksrc=author_aff"> 13 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Al-Batran+SE&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Salah-Eddin Al-Batran">Salah-Eddin Al-Batran</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Krankenhaus Nordwest, Frankfurt, Germany." href="#short-view-affiliation-14" ref="linksrc=author_aff"> 14 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Boland+PM&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Patrick M Boland">Patrick M Boland</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Roswell Park Comprehensive Cancer Center, Buffalo, NY." href="#short-view-affiliation-15" ref="linksrc=author_aff"> 15 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Crocenzi+T&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Todd Crocenzi">Todd Crocenzi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Providence Cancer Center, Portland, OR." href="#short-view-affiliation-16" ref="linksrc=author_aff"> 16 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Atreya+CE&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Chloe E Atreya">Chloe E Atreya</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA." href="#short-view-affiliation-17" ref="linksrc=author_aff"> 17 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Cui+Y&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yi Cui">Yi Cui</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="MSD China, Beijing, People's Republic of China." href="#short-view-affiliation-18" ref="linksrc=author_aff"> 18 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Dai+T&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tong Dai">Tong Dai</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Merck & Co Inc, Kenilworth, NJ." href="#short-view-affiliation-19" ref="linksrc=author_aff"> 19 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Marinello+P&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Patricia Marinello">Patricia Marinello</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Merck & Co Inc, Kenilworth, NJ." href="#short-view-affiliation-19" ref="linksrc=author_aff"> 19 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Diaz+LA+Jr&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Luis A Diaz Jr">Luis A Diaz Jr</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Memorial Sloan Kettering Cancer Center, New York, NY." href="#short-view-affiliation-20" ref="linksrc=author_aff"> 20 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Andr%C3%A9+T&cauthor_id=31725351" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Thierry André">Thierry André</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Sorbonne Université, Paris, France." href="#short-view-affiliation-21" ref="linksrc=author_aff"> 21 </a></sup></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.</li> <li data-affiliation-id="short-view-affiliation-2" id="short-view-affiliation-2" ><sup class="key">2</sup> Asan Medical Center, Seoul, Republic of Korea.</li> <li data-affiliation-id="short-view-affiliation-3" id="short-view-affiliation-3" ><sup class="key">3</sup> University Hospitals Gasthuisberg Leuven, KU Leuven, Leuven, Belgium.</li> <li data-affiliation-id="short-view-affiliation-4" id="short-view-affiliation-4" ><sup class="key">4</sup> Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.</li> <li data-affiliation-id="short-view-affiliation-5" id="short-view-affiliation-5" ><sup class="key">5</sup> Nationales Centrum Tumorerkrankungen, Heidelberg, Germany.</li> <li data-affiliation-id="short-view-affiliation-6" id="short-view-affiliation-6" ><sup class="key">6</sup> Saitama Cancer Center, Saitama, Japan.</li> <li data-affiliation-id="short-view-affiliation-7" id="short-view-affiliation-7" ><sup class="key">7</sup> Royal Brisbane and Women's Hospital, Herston, QLD, Australia.</li> <li data-affiliation-id="short-view-affiliation-8" id="short-view-affiliation-8" ><sup class="key">8</sup> Indiana University Health University Hospital, Indianapolis, IN.</li> <li data-affiliation-id="short-view-affiliation-9" id="short-view-affiliation-9" ><sup class="key">9</sup> McGill University Health Centre, Montréal, Québec, Canada.</li> <li data-affiliation-id="short-view-affiliation-10" id="short-view-affiliation-10" ><sup class="key">10</sup> National Cancer Center Hospital East, Chiba, Japan.</li> <li data-affiliation-id="short-view-affiliation-11" id="short-view-affiliation-11" ><sup class="key">11</sup> Centre Hospitalier Universitaire de Toulouse, Toulouse, France.</li> <li data-affiliation-id="short-view-affiliation-12" id="short-view-affiliation-12" ><sup class="key">12</sup> Aichi Cancer Center Hospital, Aichi, Japan.</li> <li data-affiliation-id="short-view-affiliation-13" id="short-view-affiliation-13" ><sup class="key">13</sup> Vall d'Hebron Institute of Oncology, Barcelona, Spain.</li> <li data-affiliation-id="short-view-affiliation-14" id="short-view-affiliation-14" ><sup class="key">14</sup> Krankenhaus Nordwest, Frankfurt, Germany.</li> <li data-affiliation-id="short-view-affiliation-15" id="short-view-affiliation-15" ><sup class="key">15</sup> Roswell Park Comprehensive Cancer Center, Buffalo, NY.</li> <li data-affiliation-id="short-view-affiliation-16" id="short-view-affiliation-16" ><sup class="key">16</sup> Providence Cancer Center, Portland, OR.</li> <li data-affiliation-id="short-view-affiliation-17" id="short-view-affiliation-17" ><sup class="key">17</sup> University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.</li> <li data-affiliation-id="short-view-affiliation-18" id="short-view-affiliation-18" ><sup class="key">18</sup> MSD China, Beijing, People's Republic of China.</li> <li data-affiliation-id="short-view-affiliation-19" id="short-view-affiliation-19" ><sup class="key">19</sup> Merck & Co Inc, Kenilworth, NJ.</li> <li data-affiliation-id="short-view-affiliation-20" id="short-view-affiliation-20" ><sup class="key">20</sup> Memorial Sloan Kettering Cancer Center, New York, NY.</li> <li data-affiliation-id="short-view-affiliation-21" id="short-view-affiliation-21" ><sup class="key">21</sup> Sorbonne Université, Paris, France.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">31725351</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC7031958&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7031958/" data-ga-category="full_text" data-ga-action="PMCID" > PMC7031958 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1200/JCO.19.02107&id_type=DOI" href="https://doi.org/10.1200/jco.19.02107" data-ga-category="full_text" data-ga-action="DOI" > 10.1200/JCO.19.02107 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/31725351/citations/" data-citation-style="nlm" data-pubmed-format-link="/31725351/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> <strong class="sub-title"> Purpose: </strong> KEYNOTE-164 (<a href="http://clinicaltrials.gov/show/NCT02460198" title="See in ClinicalTrials.gov">NCT02460198</a>) evaluated the antitumor activity of pembrolizumab in previously treated, metastatic, microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) colorectal cancer (CRC). </p> <p> <strong class="sub-title"> Methods: </strong> This phase II open-label study involved 128 centers worldwide. Eligible patients were age ≥ 18 years and had metastatic MSI-H/dMMR CRC treated with ≥ 2 prior lines of standard therapy, including fluoropyrimidine, oxaliplatin, and irinotecan with or without anti-vascular endothelial growth factor/epidermal growth factor receptor monoclonal antibody (cohort A) or ≥ 1 prior line of therapy (cohort B). MSI-H/dMMR status was assessed locally. Patients received pembrolizumab 200 mg every 3 weeks for up to 2 years until progression, unacceptable toxicity, or withdrawal. The primary end point was objective response rate by RECIST version 1.1 by independent central review. Secondary end points were duration of response, progression-free survival (PFS), overall survival, safety, and tolerability. </p> <p> <strong class="sub-title"> Results: </strong> A total of 124 patients with MSI-H/dMMR CRC (61 in cohort A, 63 in cohort B) enrolled. At data cutoff, median follow-up was 31.3 months (range, 0.2-35.6 months) for cohort A and 24.2 months (range, 0.1-27.1 months) for cohort B. Objective response rate was 33% (95% CI, 21% to 46%) and 33% (95% CI, 22% to 46%), respectively, with median duration of response not reached in either cohort. Median PFS was 2.3 months (95% CI, 2.1 to 8.1 months) and 4.1 months (95% CI, 2.1 to 18.9 months). Median overall survival was 31.4 months (95% CI, 21.4 months to not reached) and not reached (95% CI, 19.2 months to not reached). Treatment-related grade 3-4 adverse events occurred in 10 patients (16%) in cohort A and 8 (13%) in cohort B, with the most common occurring in ≥ 2 patients being pancreatitis, fatigue, increased alanine aminotransferase, and increased lipase (2 patients each; 3%) in cohort A. </p> <p> <strong class="sub-title"> Conclusion: </strong> Pembrolizumab is effective with a manageable safety profile in patients with MSI-H/dMMR CRC. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="fig-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/f85ea3ecda25/JCO.19.02107f1.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="756" data-image-height="1062" data-image-alt="FIG 1." data-pmc-id="PMC7031958" data-figure-id="f1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/1db840a99858/JCO.19.02107f1.gif" alt="FIG 1." /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="756"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="1062"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG 1. </p> </strong> <div class="figure-caption-contents"><p> Best percent change from baseline… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG 1. </p> </strong> <div class="figure-caption-contents"><p> Best percent change from baseline in target lesion size (RECIST version 1.1 by… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG 1. </strong> <div class="figure-caption-contents">Best percent change from baseline in target lesion size (RECIST version 1.1 by central review) by prior lines of therapy in patients with microsatellite instability–high colorectal cancer in (A) cohort A and (B) cohort B. (*) Two patients in cohort A did not have postbaseline assessments and are not included. (†) One patient in cohort B did not have postbaseline assessments and is not included.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="fig-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/560462fe8cfc/JCO.19.02107f2.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="507" data-image-height="207" data-image-alt="FIG 2." data-pmc-id="PMC7031958" data-figure-id="f2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/22b4f3925e1e/JCO.19.02107f2.gif" alt="FIG 2." /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="507"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="207"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG 2. </p> </strong> <div class="figure-caption-contents"><p> Kaplan-Meier estimates of progression-free survival… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG 2. </p> </strong> <div class="figure-caption-contents"><p> Kaplan-Meier estimates of progression-free survival (RECIST version 1.1 by central review) in patients… </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG 2. </strong> <div class="figure-caption-contents">Kaplan-Meier estimates of progression-free survival (RECIST version 1.1 by central review) in patients with microsatellite instability–high colorectal cancer (MSI-H CRC) in (A) cohort A and (B) cohort B.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="fig-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/e332d434e2c0/JCO.19.02107f3.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="507" data-image-height="203" data-image-alt="FIG 3." data-pmc-id="PMC7031958" data-figure-id="f3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/e9e9add855e7/JCO.19.02107f3.gif" alt="FIG 3." /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="507"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="203"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG 3. </p> </strong> <div class="figure-caption-contents"><p> Kaplan-Meier estimates of overall survival… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG 3. </p> </strong> <div class="figure-caption-contents"><p> Kaplan-Meier estimates of overall survival in patients with microsatellite instability–high colorectal cancer (MSI-H… </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG 3. </strong> <div class="figure-caption-contents">Kaplan-Meier estimates of overall survival in patients with microsatellite instability–high colorectal cancer (MSI-H CRC) in (A) cohort A and (B) cohort B. NR, not reached.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="fig-a1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/6306202d6b70/JCO.19.02107app1.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="768" data-image-height="1152" data-image-alt="FIG A1." data-pmc-id="PMC7031958" data-figure-id="fA.1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/d99bb0482647/JCO.19.02107app1.gif" alt="FIG A1." /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="768"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="1152"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG A1. </p> </strong> <div class="figure-caption-contents"><p> Percent change from baseline in… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG A1. </p> </strong> <div class="figure-caption-contents"><p> Percent change from baseline in target lesion size (RECIST v1.1) with time in… </p></div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG A1. </strong> <div class="figure-caption-contents">Percent change from baseline in target lesion size (RECIST v1.1) with time in patients with microsatellite instability–high/mismatch repair–deficient colorectal cancer in (A) Cohort A and (B) Cohort B. CR, complete response; PD, disease progression; PR, partial response; SD, stable disease.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="4" data-label-slug="fig-a2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/e3e8b2211a38/JCO.19.02107app2.jpg" itemprop="contentUrl" aria-describedby="figure-caption-4" role="button" data-image-width="511" data-image-height="210" data-image-alt="FIG A2." data-pmc-id="PMC7031958" data-figure-id="fA.2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-4" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/67082009c55e/JCO.19.02107app2.gif" alt="FIG A2." /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="511"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="210"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG A2. </p> </strong> <div class="figure-caption-contents"><p> Treatment exposure and duration of… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG A2. </p> </strong> <div class="figure-caption-contents"><p> Treatment exposure and duration of response by BRAF status in patients with microsatellite… </p></div> </div> <figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG A2. </strong> <div class="figure-caption-contents">Treatment exposure and duration of response by BRAF status in patients with microsatellite instability–high/mismatch repair–deficient colorectal cancer in (A) Cohort A and (B) Cohort B. CR, complete response; PR, partial response.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="5" data-label-slug="fig-a3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/cee24ed4ed4f/JCO.19.02107app3.jpg" itemprop="contentUrl" aria-describedby="figure-caption-5" role="button" data-image-width="512" data-image-height="211" data-image-alt="FIG A3." data-pmc-id="PMC7031958" data-figure-id="fA.3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-5" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/7031958/7004ee6437d2/JCO.19.02107app3.gif" alt="FIG A3." /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="512"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="211"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG A3. </p> </strong> <div class="figure-caption-contents"><p> Treatment exposure and duration of… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG A3. </p> </strong> <div class="figure-caption-contents"><p> Treatment exposure and duration of response by RAS status in patients with microsatellite… </p></div> </div> <figcaption id="figure-caption-5" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG A3. </strong> <div class="figure-caption-contents">Treatment exposure and duration of response by RAS status in patients with microsatellite instability–high/mismatch repair–deficient colorectal cancer in (A) Cohort A and (B) Cohort B. 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href="https://gco.iarc.fr/today/data/factsheets/cancers/39-All-cancers-fact-sheet.pdf" rel="noopener nofollow" target="_blank" title="External link: https://gco.iarc.fr/today/data/factsheets/cancers/39-All-cancers-fact-sheet.pdf">https://gco.iarc.fr/today/data/factsheets/cancers/39-All-cancers-fact-sh...</a>. </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34. - <a class="reference-link" href="/30620402/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="30620402" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Koopman M, Kortman GA, Mekenkamp L, et al. Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. Br J Cancer. 2009;100:266–273. - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2634718/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="PMC2634718" > PMC </a> - <a class="reference-link" href="/19165197/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="19165197" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Goldstein J, Tran B, Ensor J, et al. Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H) Ann Oncol. 2014;25:1032–1038. - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4072907/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="PMC4072907" > PMC </a> - <a class="reference-link" href="/24585723/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="24585723" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Venderbosch S, Nagtegaal ID, Maughan TS, et al. Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: A pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies. Clin Cancer Res. 2014;20:5322–5330. - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4201568/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="PMC4201568" > PMC </a> - <a class="reference-link" href="/25139339/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="25139339" > PubMed </a> </li> </ol> </li> </ol> <div class="actions-bar"> <button class="show-all" ref="linksrc=show_all_references_link" aria-controls="top-references-list-1" data-next-page-url="/31725351/references/" data-ga-category="reference" data-ga-action="show_more" > Show all 16 references </button> </div> </div> </div> </div> <div id="publication-types" class="publication-types keywords-section"> <h2 class="title"> Publication types </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword 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class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Antineoplastic+Agents%2C+Immunological%2Fadministration+and+dosage%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Antineoplastic+Agents%2C+Immunological%2Fadministration+and+dosage%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Antineoplastic Agents, Immunological/administration and dosage"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Antineoplastic Agents, Immunological / administration & dosage*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Antineoplastic+Agents%2C+Immunological" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Antineoplastic Agents, Immunological / administration & dosage*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Antineoplastic Agents, Immunological/administration and dosage"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Antineoplastic Agents, Immunological/administration and dosage"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Antineoplastic Agents, Immunological / adverse effects" tabindex="0" aria-controls="keyword-actions-mesh-terms-6" aria-expanded="false" data-pinger-ignore> Antineoplastic Agents, Immunological / adverse effects </button><div id="keyword-actions-mesh-terms-6" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Antineoplastic Agents, Immunological / adverse effects"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Antineoplastic+Agents%2C+Immunological%2Fadverse+effects%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Antineoplastic+Agents%2C+Immunological%2Fadverse+effects%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Antineoplastic Agents, Immunological/adverse effects"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Antineoplastic Agents, Immunological / adverse effects"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Antineoplastic+Agents%2C+Immunological" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Antineoplastic Agents, Immunological / adverse effects"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Antineoplastic Agents, Immunological/adverse effects"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Antineoplastic Agents, Immunological/adverse effects"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Cohort Studies" tabindex="0" aria-controls="keyword-actions-mesh-terms-7" aria-expanded="false" data-pinger-ignore> Cohort Studies </button><div id="keyword-actions-mesh-terms-7" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Cohort Studies"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Cohort+Studies%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Cohort+Studies%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Cohort Studies"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Cohort Studies"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Cohort+Studies" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Cohort Studies"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Cohort Studies"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Cohort Studies"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Colorectal Neoplasms / drug therapy*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-8" aria-expanded="false" data-pinger-ignore> Colorectal Neoplasms / drug therapy* </button><div id="keyword-actions-mesh-terms-major-8" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Colorectal Neoplasms / drug therapy*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Colorectal+Neoplasms%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Colorectal+Neoplasms%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Colorectal Neoplasms/drug therapy"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Colorectal Neoplasms / drug therapy*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Colorectal Neoplasms / drug therapy*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Colorectal Neoplasms/drug therapy"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Colorectal Neoplasms/drug therapy"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Colorectal Neoplasms / genetics*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-9" aria-expanded="false" data-pinger-ignore> Colorectal Neoplasms / genetics* </button><div id="keyword-actions-mesh-terms-major-9" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Colorectal Neoplasms / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Colorectal+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Colorectal+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Colorectal Neoplasms/genetics"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Colorectal Neoplasms / genetics*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Colorectal Neoplasms / genetics*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Colorectal Neoplasms/genetics"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Colorectal Neoplasms/genetics"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword DNA Mismatch Repair*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-10" aria-expanded="false" data-pinger-ignore> DNA Mismatch Repair* </button><div id="keyword-actions-mesh-terms-major-10" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword DNA Mismatch Repair*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22DNA+Mismatch+Repair%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22DNA+Mismatch+Repair%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="DNA Mismatch Repair"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="DNA Mismatch Repair*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=DNA+Mismatch+Repair" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="DNA Mismatch Repair*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""DNA Mismatch Repair"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""DNA Mismatch Repair"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Drug Administration Schedule" tabindex="0" aria-controls="keyword-actions-mesh-terms-11" aria-expanded="false" data-pinger-ignore> Drug Administration Schedule </button><div id="keyword-actions-mesh-terms-11" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Drug Administration Schedule"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Drug+Administration+Schedule%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Drug+Administration+Schedule%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Drug Administration Schedule"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Drug Administration Schedule"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Drug+Administration+Schedule" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Drug Administration Schedule"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Drug Administration Schedule"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Drug Administration Schedule"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Female" tabindex="0" aria-controls="keyword-actions-mesh-terms-12" aria-expanded="false" data-pinger-ignore> Female </button><div id="keyword-actions-mesh-terms-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Female"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Female%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Female%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Female"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Female"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Female" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Female"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Female"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Female"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Humans" tabindex="0" aria-controls="keyword-actions-mesh-terms-13" aria-expanded="false" data-pinger-ignore> Humans </button><div id="keyword-actions-mesh-terms-13" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Humans"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Humans"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Humans"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Humans"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Humans"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Infusions, Intravenous" tabindex="0" aria-controls="keyword-actions-mesh-terms-14" aria-expanded="false" data-pinger-ignore> Infusions, Intravenous </button><div id="keyword-actions-mesh-terms-14" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Infusions, Intravenous"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Infusions%2C+Intravenous%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Infusions%2C+Intravenous%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Infusions, Intravenous"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Infusions, Intravenous"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Infusions%2C+Intravenous" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Infusions, Intravenous"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Infusions, Intravenous"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Infusions, Intravenous"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Male" tabindex="0" aria-controls="keyword-actions-mesh-terms-15" aria-expanded="false" data-pinger-ignore> Male </button><div id="keyword-actions-mesh-terms-15" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Male"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Male"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Male"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Male" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Male"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Male"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Male"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Microsatellite Instability*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-16" aria-expanded="false" data-pinger-ignore> Microsatellite Instability* </button><div id="keyword-actions-mesh-terms-major-16" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Microsatellite Instability*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Microsatellite+Instability%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Microsatellite+Instability%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Microsatellite Instability"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Microsatellite Instability*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Microsatellite+Instability" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Microsatellite Instability*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Microsatellite Instability"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Microsatellite Instability"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Middle Aged" tabindex="0" aria-controls="keyword-actions-mesh-terms-17" aria-expanded="false" data-pinger-ignore> Middle Aged </button><div id="keyword-actions-mesh-terms-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Middle Aged"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Middle Aged"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Middle Aged"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Middle+Aged" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Middle Aged"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Middle Aged"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Middle Aged"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Treatment Outcome" tabindex="0" aria-controls="keyword-actions-mesh-terms-18" aria-expanded="false" data-pinger-ignore> Treatment Outcome </button><div id="keyword-actions-mesh-terms-18" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Treatment Outcome"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Treatment+Outcome%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Treatment+Outcome%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Treatment Outcome"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Treatment Outcome"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Treatment+Outcome" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Treatment Outcome"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Treatment Outcome"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Treatment Outcome"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Young Adult" tabindex="0" aria-controls="keyword-actions-mesh-terms-19" aria-expanded="false" data-pinger-ignore> Young Adult </button><div id="keyword-actions-mesh-terms-19" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Young Adult"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Young+Adult%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Young+Adult%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Young Adult"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Young Adult"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Young+Adult" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Young Adult"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Young Adult"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Young Adult"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Antibodies, Monoclonal, Humanized" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> Antibodies, Monoclonal, Humanized </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Antibodies, Monoclonal, Humanized"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Antibodies%2C+Monoclonal%2C+Humanized%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Antibodies%2C+Monoclonal%2C+Humanized%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Antibodies, Monoclonal, Humanized"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Antibodies, Monoclonal, Humanized"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Antibodies%2C+Monoclonal%2C+Humanized%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Antibodies, Monoclonal, Humanized"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Antibodies, Monoclonal, Humanized"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Antibodies, Monoclonal, Humanized"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Antineoplastic Agents, Immunological" tabindex="0" aria-controls="keyword-actions-substances-1" aria-expanded="false" data-pinger-ignore> Antineoplastic Agents, Immunological </button><div id="keyword-actions-substances-1" class="keyword-actions-dropdown dropdown dropdown-container" 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Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: KEYNOTE-164 - PubMed