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<!DOCTYPE html> <html lang="en"> <head> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta name="format-detection" content="telephone=no"> <link rel="canonical" href="https://www.pulsus.com/abstract/presynaptic-dysfunction-in-developmental-and-epileptic-encephalopathies-synaptopathies-in-developmental-and-epileptic-en-10405.html"> <link rel="alternate" href="https://www.pulsus.com/abstract/presynaptic-dysfunction-in-developmental-and-epileptic-encephalopathies-synaptopathies-in-developmental-and-epileptic-en-10405.html" hreflang="en"/> <meta name="ROBOTS" content="INDEX,FOLLOW"> <meta name="googlebot" content="INDEX,FOLLOW"> <meta name="google-site-verification" content="EWYHnSFnfoIJJ1MEuBg2fdhwKNr_vX5Sm_3KMDh-CBM" /> <link rel="shortcut icon" href="https://www.pulsus.com/images/favicon.ico" type="image/x-icon"> <link rel="icon" href="https://www.pulsus.com/images/favicon.ico" type="image/x-icon">  <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.1.1/css/bootstrap.min.css"> <link rel="stylesheet" href="https://use.fontawesome.com/releases/v5.0.10/css/all.css"> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css"> <link rel="stylesheet" href="//cdnjs.cloudflare.com/ajax/libs/metisMenu/2.7.7/metisMenu.min.css"> <link href="https://www.pulsus.com/css/global.css" rel="stylesheet" type="text/css"> <link href="https://www.pulsus.com/css/styles.css" rel="stylesheet" type="text/css"> <link href="https://www.pulsus.com/assets/css/author.css" rel="stylesheet" type="text/css">  <script src="https://ajax.googleapis.com/ajax/libs/jquery/3.3.1/jquery.min.js"></script> <link rel="stylesheet" type="text/css" href="/css/main-coolautosuggest.css"/> <script async src="https://www.pulsus.com/js/jquery.coolautosuggest.js"></script> <script async src="https://www.pulsus.com/js/jquery.coolfieldset.js"></script>   <script async src="https://www.googletagmanager.com/gtag/js?id=G-VJ1G6PL033"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-VJ1G6PL033'); </script> <script type="application/ld+json"> { "@context": "https://schema.org", "@type": "Organization", "url": "https://www.pulsus.com/", "logo": "https://www.pulsus.com/images/pulsus-logo-red.svg" } </script>  <script> !function(f,b,e,v,n,t,s){if(f.fbq)return;n=f.fbq=function(){n.callMethod? n.callMethod.apply(n,arguments):n.queue.push(arguments)};if(!f._fbq)f._fbq=n; n.push=n;n.loaded=!0;n.version='2.0';n.queue=[];t=b.createElement(e);t.async=!0; t.src=v;s=b.getElementsByTagName(e)[0];s.parentNode.insertBefore(t,s)}(window, document,'script','//connect.facebook.net/en_US/fbevents.js'); fbq('init', '297919997051754'); fbq('track', "PageView"); </script> <title>Pre-synaptic Dysfunction in Developmental and Epileptic Encephalopathies Synaptopathies in Developmental and Epileptic Encephalopathies | Abstract</title> <meta name="keywords" content="Priyanshu Sharma, Pre-synaptic Dysfunction, Epileptic, Encephalopathies"/> <meta name="description" content="The pre- and post-synaptic membranes, the synaptic cleft, and the surrounding glial cells and extracellular matrix all play a role in the correct conn.. "/> <meta name="citation_publisher" content="Pulsus Group" /> <meta name="citation_journal_title" content="Journal of Neurology and Clinical Neuroscience"> <meta name="citation_title" content="Pre-synaptic Dysfunction in Developmental and Epileptic Encephalopathies Synaptopathies in Developmental and Epileptic Encephalopathies"> <meta name="citation_author" content="Priyanshu Sharma" /> <meta name="citation_year" content="2022"> <meta name="citation_volume" content="6"> <meta name="citation_issue" content="2"> <meta name="citation_issn" content="2752-809X"> <meta name="citation_publication_date" content="2022/03/28" /> <meta name="citation_abstract" content="The pre- and post-synaptic membranes, the synaptic cleft, and the surrounding glial cells and extracellular matrix all play a role in the correct connection between pre- and post-synaptic nerve cells. Synaptopathy is a change in the systems that control the physiological synergy between these synaptic components. Several neuropsychiatric illnesses are linked to mutations in genes producing proteins involved in neuronal transmission, but only a few are linked to Developmental and Epileptic Encephalopathies (DEEs). A diverse set of epileptic syndromes linked with cognitive disturbances/intellectual impairment, autistic traits, and movement abnormalities make up these ailments. This review focuses on processes influencing the neuronal pre-synaptic terminal and its function in the development of DEEs in order to better understand the aetiology of these diseases."> <meta name="citation_pdf_url" content="https://www.pulsus.com/scholarly-articles/presynaptic-dysfunction-in-developmental-and-epileptic-encephalopathies-synaptopathies-in-developmental-and-epileptic-en.pdf"> <meta name="citation_abstract_html_url" content="https://www.pulsus.com/abstract/presynaptic-dysfunction-in-developmental-and-epileptic-encephalopathies-synaptopathies-in-developmental-and-epileptic-en-10405.html"> </head> <body> <header class="m-b-0"> <div class="container py-3 d-none d-lg-block"> <div class="row justify-content-between"> <div class="col-12 col-sm-4 col-md-3"> <a href="https://www.pulsus.com/" title="Pulsus Group"> <img alt="Pulsus" src="/images/pulsus-logo-red.svg" class="img-fluid"></a> </div> <div class="col-12 col-sm-8 my-4 my-sm-0"> <a href="https://www.pulsus.com/submit-manuscript.html"><img alt="Pulsus health tech" src="/images/80.jpg" class="img-fluid float-right" /></a> </div> </div> </div> <div class="container"> <a href="tel:+44 2033180199"><i class="fa fa-phone" aria-hidden="true"></i> 44 2033180199</a> </div> <div class="whatup"> <ul> <li><a href="tel:+44 7389646106">+44 7389646106<i class="fa fa-whatsapp" aria-hidden="true"></i></a></li> </ul> </div> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light bg-transparent main-nav">  <a class="navbar-brand d-lg-none" href="#"><img alt="Pulsus" src="https://www.pulsus.com/images/pulsus-logo-red.svg" class="img-fluid" width="150"></a> <button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#main-menu" aria-controls="main-menu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button>  <div class="collapse navbar-collapse justify-content-start" id="main-menu" > <div class="navbar-nav"> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="javascript:void(0)" data-target="#" id="AboutPulsus" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> About </a> <div class="dropdown-menu" aria-labelledby="AboutPulsus"> <a class="dropdown-item" href="https://www.pulsus.com/pulsus-profile.html" title="Pulsus Profile">Pulsus Profile</a> <a class="dropdown-item" href="https://www.pulsus.com/abstracting-indexing.html" title="Abstracting and Indexing">Abstracting and Indexing</a> <a class="dropdown-item" href="https://www.pulsus.com/editorial-policy-and-review-process.html" title="Editorial Policy and Review Process">Editorial Policy and Review Process</a> </div> </div> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle" data-target="#" href="javascript:void(0)" id="Journals" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Journals </a> <div class="dropdown-menu" aria-labelledby="Journals"> <a class="dropdown-item" href="https://www.pulsus.com/journals.html" title="A-Z Journals">A-Z Journals</a> <a class="dropdown-item" href="https://www.pulsus.com/scientific-journals.html" title="Browse By Subject">Browse By Subject</a> </div> </div>  <a class="nav-item nav-link" href="https://www.pulsus.com/international-scientific-conferences.html" target="_blank" title="Pulsus Conferences">Conferences</a> <a class="nav-item nav-link" href="https://www.pulsus.com/membership.html" title="Membership">Membership</a> <a class="nav-item nav-link" href="https://www.pulsus.com/covid-19-peer-reviewed-journals-articles-special-issues.html" title="COVID-19">Covid-19 Journal Articles Issues</a> <a class="nav-item nav-link" href="https://www.pulsus.com/contactus.html" title="Contact Us">Contact Us</a> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="javascript:void(0)" data-target="#" id="AboutPulsus" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Careers </a> <div class="dropdown-menu" aria-labelledby="AboutPulsus"> <a class="dropdown-item" href="https://www.pulsus.com/careers/pulsus-hyderabad-jobs-vacancies-salaries-reviews.html" title="Click here">Hyderabad </a> <a class="dropdown-item" href="https://www.pulsus.com/careers/pulsus-gurgaon-jobs-vacancies-salaries-reviews.html" title="Click here">Gurgaon </a> <a class="dropdown-item" href="https://www.pulsus.com/careers/pulsus-chennai-jobs-vacancies-salaries-reviews.html" title="Click here">Chennai </a> <a class="dropdown-item" href="https://www.pulsus.com/careers/pulsus-vizag-jobs-vacancies-salaries-reviews.html" title="Click here">Vizag </a> </div> </div> <a class="nav-item nav-link" href="https://www.pulsus.com/skill-development.html" title="Skill Development">Skill Development</a> </div>  </div>   <div id="google_translate_element"></div> <script> function googleTranslateElementInit() { new google.translate.TranslateElement( { pageLanguage: 'en' }, 'google_translate_element' ); 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href="presynaptic-dysfunction-in-developmental-and-epileptic-encephalopathies-synaptopathies-in-developmental-and-epileptic-en-10405.html" title="Pre-synaptic Dysfunction in Developmental and Epileptic Encephalopathies Synaptopathies in Developmental and Epileptic Encephalopathies">Pre-synaptic Dysfunction in Developmental and Epileptic Encephalopathies Synaptopathies in Developmental and Epileptic Encephalopathies</a></h3> <strong>Author(s):</strong> <em> <a href='https://www.pulsus.com/author/priyanshu-sharma-13946' style='color:#555; border-bottom:1px dotted #CCC;' title='Priyanshu Sharma'>Priyanshu Sharma</a>* </em><br /><br /> <p>The pre- and post-synaptic membranes, the synaptic cleft, and the surrounding glial cells and extracellular matrix all play a role in the correct connection between pre- and post-synaptic nerve cells. Synaptopathy is a change in the systems that control the physiological synergy between these synaptic components. Several neuropsychiatric illnesses are linked to mutations in genes producing proteins involved in neuronal transmission, but only a few are linked to Developmental and Epileptic Encephalopathies (DEEs). A diverse set of epileptic syndromes linked with cognitive disturbances/intellectual impairment, autistic traits, and movement abnormalities make up these ailments. This review focuses on processes influencing the neuronal pre-synaptic terminal and its function in the development of DEEs in order to better understand the aetiology of these diseases.</p><br> <a href="https://www.pulsus.com/scholarly-articles/presynaptic-dysfunction-in-developmental-and-epileptic-encephalopathies-synaptopathies-in-developmental-and-epileptic-en.pdf" title="PDF">PDF</a> </div>  <div class="col-md-2"><ul class="sidebar-soc"> <li><a class="soc-twitter" href="https://twitter.com/pulsus5" target="_blank"></a></li> <li><a class="soc-linkedin" href="https://www.linkedin.com/company/pulsus-journals" target="_blank"></a></li> <li><a class="soc-rss soc-icon-last" href="https://www.pulsus.com/rss/journal-of-neurology-and-clinical-neuroscience.xml" title="Click here"></a></li> </ul> <div> </div>     <div class="mx-auto d-none d-sm-block"> <a class="twitter-timeline" href="https://twitter.com/clinicaneurosci" data-width="300" data-height="400">Tweets by clinicaneurosci</a> <script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script> </div>     <h6><a target="_blank" style="color: #2b7bb9;" href="https://scholar.google.com/citations?user=xHMu03UAAAAJ&hl=en" title="Click here">Google Scholar citation report</a></h6> <h6 style="font-weight:bold;">Citations : 500</h6> <p><a target="_blank" href="https://scholar.google.com/citations?user=xHMu03UAAAAJ&hl=en" title="Click here">Journal of Neurology and Clinical Neuroscience received 500 citations as per Google Scholar report</a></p> <div class="card shadow-sm sidebar mb-3 mt-3"> <a href="https://www.pulsus.com/journal-neurology-clinical-neuroscience/citations.html" title="Click here"><img src="https://www.pulsus.com/admin/citation-images/journal-of-neurology-and-clinical-neuroscience-citation.png" alt="Flyer image" class="img-fluid p_rel" /></a> </div>  <h6><a href="https://publons.com/journal/66433/journal-of-neurology-and-clinical-neuroscience/" style="color: #2b7bb9;" target="_blank" title="Click here">Journal of Neurology and Clinical Neuroscience peer review process verified at publons</a></h6> <div class="card shadow-sm sidebar mb-3 mt-3"> <a href="https://publons.com/journal/66433/journal-of-neurology-and-clinical-neuroscience/" target="_blank" title="Click here"><img src="https://www.pulsus.com/admin/publon-images/journal-of-neurology-and-clinical-neuroscience-publon.png" alt="Publon image" class="img-fluid p_rel" height="200px" /></a> </div> <div class="card shadow-sm sidebar mb-3"> <h4 class="card-header pr-0" style="padding:6px 0px 6px 7px; 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