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ASPET | Keynote Speakers
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title-block" style="" data-placeholder-label="Title Block Container"> <div id="ContentPlaceholder_T76CE7C69010_Col00" class="sf_colsIn sf_1col_1in_100"><div class="sf_cols "> <div class="sf_colsOut title-block__background" style="" data-placeholder-label="Tile Block Photo"> <div id="ContentPlaceholder_T76CE7C69011_Col00" class="sf_colsIn sf_1col_1in_100"> <div > <div class="sfContentBlock sf-Long-text" ><img src="/images/default-source/meeting-and-event-images/aspet2024/page-panners/keynote-speaker.jpg" alt="Keynote Speakers" /></div> </div> </div> </div> </div><div class="sf_cols "> <div class="sf_colsOut title-block__content page-bounds" style="" data-placeholder-label="Title Block Content"> <div id="ContentPlaceholder_T76CE7C69012_Col00" class="sf_colsIn sf_1col_1in_100"> <h1>Keynote Speakers</h1><div id="ContentPlaceholder_T76CE7C69006"> <div class="breadcrumb"> <span id="ContentPlaceholder_T76CE7C69006_ctl00_ctl00_BreadcrumbLabel" class="sfBreadcrumbLabel" 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class="interior-nav "> <h5 class="interior-nav__title" data-toggle-target="next">In This Section</h5> <nav class="interior-nav__nav"> <ul id="ContentPlaceholder_T76CE7C69007_ctl00_ctl00_navigationUl"> <li> <a href="/aspet/meetings-awards/meetingsannual-meeting/annual-meeting-archives/aspet-2024/aspet-2024-annual-meeting-program/aspet-committee-and-board-meetings">ASPET Committee and Board Meetings</a> </li> <li> <a href="/aspet/meetings-awards/meetingsannual-meeting/annual-meeting-archives/aspet-2024/aspet-2024-annual-meeting-program/explore-dc">Explore DC</a> </li> <li> <a href="/aspet/meetings-awards/meetingsannual-meeting/annual-meeting-archives/aspet-2024/aspet-2024-annual-meeting-program/division-town-halls">ASPET Town Halls</a> </li> <li> <a href="/aspet/meetings-awards/meetingsannual-meeting/annual-meeting-archives/aspet-2024/aspet-2024-annual-meeting-program/opportunities-for-students-postdocs">Opportunities for Students/Postdocs</a> </li> <li> <a href="/aspet/meetings-awards/meetingsannual-meeting/annual-meeting-archives/aspet-2024/aspet-2024-annual-meeting-program/aspet-capitol-hill-day">ASPET Capitol Hill Day</a> </li> <li> <a href="/aspet/meetings-awards/meetingsannual-meeting/annual-meeting-archives/aspet-2024/aspet-2024-annual-meeting-program/program-details">Program Details</a> </li> <li class="is-current"> <a href="/aspet/meetings-awards/meetingsannual-meeting/annual-meeting-archives/aspet-2024/aspet-2024-annual-meeting-program/keynote-speakers">Keynote Speakers</a> </li> <li> <a href="/aspet/meetings-awards/meetingsannual-meeting/annual-meeting-archives/aspet-2024/aspet-2024-annual-meeting-program/online-programming">Online Programming</a> </li> </ul> </nav> </div> </div> </div> <div class="sf_colsOut interior-layout__main" style="width: 25%;" data-placeholder-label="Main"> <div id="ContentPlaceholder_T76CE7C69009_Col02" class="sf_colsIn sf_4cols_3in_25"><div id="ContentPlaceholder_C005_Col00" class="sf_colsIn container" data-sf-element="Container"><div class="sf_cols" data-sf-element="Row"> <div class="sf_colsOut sf_1col_1_100"> <div id="ContentPlaceholder_C032_Col00" class="sf_colsIn sf_1col_1in_100" data-sf-element="Column 1"> <div > <div class="sfContentBlock sf-Long-text" ><!--<div class="grid"> <div class="grid__unit grid__unit--1-2"> <div class="card card--primary"> <div class="card__body"><img src="/images/default-source/meeting-and-event-images/aspet2024/thumbnail_bernard-mariepic.png" title="Bernard Marie" /></div> </div> </div> <div class="grid__unit grid__unit--1-2"> <div class="card card--primary"> <div class="card-grid"> <div class="card" style="border:1px solid #ffff;"> <div class="card__body"> <h3 id="name" class="header">Marie A. Bernard, M.D.</h3> <div class="button button--action button--tertiary">Chief Officer for Scientific Workforce Diversity (COSWD)</div><em></em><em></em> <div class="card__body"> <div class="card__footer" style="border-color:#F05A28;padding-bottom:3em;"> <p class="header">Deputy Director of the National Institute on Aging (NIA) </p> </div> <h3 id="Bernard" class="header">Diverse Perspectives in Science: Why and How?</h3> </div> <div class="card__body" style="border-color:#F05A28;"><em></em> <p>Marie A. Bernard, M.D., is the National Institutes of Health (NIH) Chief Officer for Scientific Workforce Diversity (COSWD). As the COSWD, she leads NIH thought regarding the science of scientific workforce diversity, assuring that the full range of talent is accessed to promote scientific creativity and innovation. Dr. Bernard co-led the development and is co-leading the implementation of the Fiscal Years 2023 – 2027 NIH-wide Strategic Plan for Diversity, Equity, Inclusion, and Accessibility (DEIA). She also cochairs the NIH Advisory Committee to the Director Working Group on Diversity, the NIH Steering Committee Working Group on DEIA, and the NIH UNITE initiative to identify and address any structural racism that may exist within NIH and throughout the biomedical and behavioral workforce. Prior to being selected as the COSWD, Dr. Bernard served as the Deputy Director of the National Institute on Aging (NIA), following a productive research and leadership career as an academic geriatrician. </p> </div> </div> </div> </div> </div> </div> </div>--></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><div class="grid"><div class="grid__unit grid__unit--1-2"><div class="card card--primary"><div class="card__body" style="padding-bottom:3.5em;"><img src="/images/default-source/meeting-and-event-images/aspet2024/thumbnail_bernard-mariepic.png" style="height:auto;" title="Marie A. Bernard" width="310" /></div></div></div><div class="grid__unit grid__unit--1-2"><div class="card card--primary"><div class="card-grid"><div class="card" style="border:1px solid #ffff;"><div class="card__body" style="margin-top:3em;padding-top:3em;"><h3 id="name" class="header">Marie A. Bernard, M.D.</h3><div class="button button--action button--tertiary">Chief Officer for Scientific Workforce Diversity (COSWD)</div><em></em><em></em><div class="card__body"><div class="card__footer" style="border-color:#F05A28;padding-bottom:3em;text-align:center;"><em>National Institutes of Health (NIH)</em></div></div></div></div></div></div></div></div></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><div class="card card--primary"><div class="card__body" style="border-color:#F05A28;"><em></em><h3 id="Bernard" class="header">Diverse Perspectives in Science: Why and How?</h3><p>Marie A. Bernard, M.D., is the National Institutes of Health (NIH)* Chief Officer for Scientific Workforce Diversity (COSWD). As the COSWD, she leads NIH thought regarding the science of scientific workforce diversity, assuring that the full range of talent is accessed to promote scientific creativity and innovation. Dr. Bernard co-led the development and is co-leading the implementation of the Fiscal Years 2023 – 2027 NIH-wide Strategic Plan for Diversity, Equity, Inclusion, and Accessibility (DEIA). She also cochairs the NIH Advisory Committee to the Director Working Group on Diversity, the NIH Steering Committee Working Group on DEIA, and the NIH UNITE initiative to identify and address any structural racism that may exist within NIH and throughout the biomedical and behavioral workforce. Prior to being selected as the COSWD, Dr. Bernard served as the Deputy Director of the National Institute on Aging (NIA), following a productive research and leadership career as an academic geriatrician.</p><p><em>*Disclaimer: No endorsement of ASPET, their programs or services, by NIH is intended. </em></p></div></div></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><div class="space-b-050 space-t-050 space-b-250-m space-t-250-m"></div></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><div class="grid" id="suliman"><div class="grid__unit grid__unit--1-2"><div class="card card--primary"><div class="card__body" style="padding-bottom:3.5em;"><img src="//www.aspet.org/images/default-source/meeting-and-event-images/aspet2024/shehnaazsuliman-web.png" style="height:auto;" title="Shehnaaz Suliman" width="310" /></div></div></div><div class="grid__unit grid__unit--1-2"><div class="card card--primary"><div class="card-grid"><div class="card" style="border:1px solid #ffff;"><div class="card__body" style="margin-top:3em;padding-top:3em;"><h3 id="name" class="header">Shehnaaz Suliman, M.D., M.Phil. MBA</h3><div class="button button--action button--tertiary" style="width:100%;" id="speaker_s">Chief Executive Officer </div><em></em></div><div class="card__footer" style="border-color:#F05A28;padding-bottom:3em;text-align:center;"><em>ReCode Therapeutics</em></div><!-- <div class="card__body"> <div class="card__footer" style="border-color:#F05A28;padding-bottom:3em;text-align:center;"><em>ReCode Therapeutics</em></div> </div>--> </div></div></div></div></div></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><div class="card card--primary"><div class="card__body" style="border-color:#F05A28;"><em></em><h3 class="header">What’s Next in Biotech? Where We Are and Where Are We Headed</h3><p>Dr. Shehnaaz Suliman is CEO of ReCode Therapeutics – a leading genetic medicines company focused on powering the next wave of genetic medicines through tissue-specific lipid nanoparticle delivery. Dr. Suliman is a physician, drug-developer, company builder and has played a leading role over 25 years in transforming high growth companies through advancing clinical pipelines and executing partnerships and acquisitions at Alector, Theravance, Genentech, Roche and Gilead. Dr. Suliman has been honored by <em>Forbes</em>, Fierce Biotech, <em>Silicon Valley Business Journal</em> and <em>San Francisco Business Times</em> as a nationally acclaimed leader female business leader and advocate for healthcare equity and access. She received her M.D. at the University of Cape Town Medical School, South Africa, and holds an MBA, with distinction, and M.Phil. degrees from Oxford University, where she was a Rhodes Scholar. Dr. Suliman serves on the Ultragenyx Pharmaceutical and 10x Genomic Boards. Dr. Suliman is forging paths for underrepresented individuals with the Board Room Ready program and is a mentor to dozens of rising stars. </p></div></div></div> </div> </div> </div> </div> <div > <div class="sfContentBlock sf-Long-text" ><div class="space-b-050 space-t-050 space-b-250-m space-t-250-m"></div></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><div class="grid" id="shoichet"><div class="grid__unit grid__unit--1-2"><div class="card card--primary"><div class="card__body" style="padding-bottom:3.5em;"><img src="https://www.aspet.org/images/default-source/meeting-and-event-images/aspet2024/brian-shoichet.png" style="height:auto;" title="Brian Shoichet" width="310" /></div></div></div><div class="grid__unit grid__unit--1-2"><div class="card card--primary"><div class="card-grid"><div class="card" style="border:1px solid #ffff;"><div class="card__body" style="margin-top:3em;padding-top:3em;"><h3 id="name" class="header">Brian Shoichet, PhD</h3><div class="button button--action button--tertiary" style="width:100%;" id="speaker_s">Professor, Pharmaceutical Chemistry </div><em></em><div class="card__footer" style="border-color:#F05A28;padding-bottom:3em;text-align:center;"><em>University of California, San Francisco </em></div></div></div></div></div></div></div></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><div class="card card--primary"><div class="card__body" style="border-color:#F05A28;"><em></em><h3 class="header">Following the Rabbit into Chemical Space</h3><p>Dr. Brian Shoichet is a Professor of Pharmaceutical Chemistry at the University of California, San Francisco. Recently, docking libraries have expanded from three million “in-stock” to billions of make-on-demand (“tangible”) molecules. Docking these new libraries has revealed novel scaffolds with nM and sub-nM potencies directly from the docking.</p><p>Dr. Shoichet will discuss recent applications to several targets where in vivo active leads have been developed for analgesia and for metabolic control. In the Shoichert Lab, scientists are developing new computational methods for ligand discovery and applying these to G-Protein Coupled Receptors (GPCR). </p><p>His lab develops new molecular docking and chemoinformatics methods that are tested in experimental model systems, and applied to targets of active biological interest, often GPCRs. </p></div></div></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><div class="space-b-050 space-t-050 space-b-250-m space-t-250-m"></div></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><div class="grid" id="shoichet"><div class="grid__unit grid__unit--1-2"><div class="card card--primary"><div class="card__body" style="padding-bottom:3.5em;"><img src="/images/default-source/meeting-and-event-images/aspet2024/julie-lade.png" style="height:auto;" title="Julie Lade" width="310" /></div></div></div><div class="grid__unit grid__unit--1-2"><div class="card card--primary"><div class="card-grid"><div class="card" style="border:1px solid #ffff;"><div class="card__body" style="-top:3em;padding-top:3em;"><h3 id="name" class="header">Julie Lade, PhD</h3><div class="button button--action button--tertiary" style="width:100%;" id="speaker_s">Scientific Associate Director </div><em></em><div class="card__footer" style="border-color:#F05A28;padding-bottom:3em;text-align:center;"><p><em>Amgen</em></p></div></div></div></div></div></div></div></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><div class="card card--primary"><div class="card__body" style="border-color:#F05A28;"><em></em><h3 class="header">Government Leadership Panel on the Cancer Moonshot Initiative</h3><p>Featuring leaders from the Food and Drug Administration (FDA), National Cancer Institute (NCI), the Advanced Research Projects Agency for Health (ARPA-H), and the White House Office of Science and Technology Policy (OSTP), this panel will discuss the critical work occurring in various parts of the federal government focused on the Cancer Moonshot Initiative. Moderated by Julie Lade, PhD, Scientific Associate Director with Amgen, panelists will share how their agency has contributed to the fight against cancer, what their future initiatives in this area will focus on to drive progress across the cancer journey and how their work will impact the field of pharmacology. </p><p>Dr. Lade's work focuses on driving preclinical and clinical development of small molecules and RNA therapeutics across several therapeutic areas. She has been an active member of ASPET since 2014 and is currently on the executive committee for the Division of Drug Metabolism & Disposition as acting secretary/treasurer. </p></div></div></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><!--<div class="card card--primary"> <div class="card__body" style="border-color:#F05A28;"><em></em> <h3 class="header">Meet the Panelists</h3> <p><strong>Tamy Kim, PharmD</strong><br />Director for Regulatory Affairs and Regulatory Policy<br />U.S. Food and Drug Administration</p> <p><strong>James H. Doroshow, MD</strong><br />Director, Division of Cancer Treatment and Diagnosis<br />National Cancer Institute, NIH</p> <p><strong>Melissa Antman, PhD</strong><br />Deputy Director, PATIO<br />Advanced Research Projects Agency for Health (ARPA-H)</p> </div> </div>--></div> </div><div class="sf_cols" data-sf-element="Row"> <div class="sf_colsOut sf_2cols_1_33"> <div id="ContentPlaceholder_C029_Col00" class="sf_colsIn sf_2cols_1in_33" data-sf-element="Column 1"> <div > <div class="sfContentBlock sf-Long-text" ><!--<img src="/images/default-source/meeting-and-event-images/aspet2024/thumbnail_bernard-mariepic.png" title="Bernard Marie" />--> <!--<div style="position:relative;padding-bottom:56.25%;padding-top:30px;height:0;overflow:hidden;width:100%;max-width:100%;max-height:calc(100vh - 64px);margin-top:2%;"><iframe width="100%" height="315" src="https://www.youtube.com/embed/5HCKtb4rbAw?rel=0?version=3&modestbranding=1&autoplay=1&mute=1&playlist=5HCKtb4rbAw&loop=1" title="Dr. Yasmin Hurd" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen="" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></div>--></div> </div> </div> </div> <div class="sf_colsOut sf_2cols_2_67"> <div id="ContentPlaceholder_C029_Col01" class="sf_colsIn sf_2cols_2in_67" data-sf-element="Column 2"> <div > <div class="sfContentBlock sf-Long-text" ><!--<div class="card-grid"> <div class="card" style="border:1px solid #ffff;"> <div class="card__body"> <h3 id="Bernard" class="header">Marie A. Bernard, M.D.</h3> <div class="button button--action button--tertiary">Chief Officer for Scientific Workforce Diversity (COSWD)</div><em></em></div><em></em> <div class="card__footer"><em></em> <p class="header">Deputy Director of the National Institute on Aging (NIA) </p> </div> </div> </div>--></div> </div> <div > <div class="sfContentBlock sf-Long-text" ><!--<div class="space-b-050 space-t-050 space-b-250-m space-t-250-m"></div> <h6><em>Diverse Perspectives in Science: Why and How?</em></h6> <p>Marie A. Bernard, M.D., is the National Institutes of Health (NIH) Chief Officer for Scientific Workforce Diversity (COSWD). As the COSWD, she leads NIH thought regarding the science of scientific workforce diversity, assuring that the full range of talent is accessed to promote scientific creativity and innovation. Dr. Bernard co-led the development and is co-leading the implementation of the Fiscal Years 2023 – 2027 NIH-wide Strategic Plan for Diversity, Equity, Inclusion, and Accessibility (DEIA). She also cochairs the NIH Advisory Committee to the Director Working Group on Diversity, the NIH Steering Committee Working Group on DEIA, and the NIH UNITE initiative to identify and address any structural racism that may exist within NIH and throughout the biomedical and behavioral workforce. Prior to being selected as the COSWD, Dr. Bernard served as the Deputy Director of the National Institute on Aging (NIA), following a productive research and leadership career as an academic geriatrician. </p>--></div> </div> </div> </div> </div><div class="sf_cols" data-sf-element="Row"> <div class="sf_colsOut sf_2cols_1_50"> <div id="ContentPlaceholder_C014_Col00" class="sf_colsIn sf_2cols_1in_50" data-sf-element="Column 1"> </div> </div> <div class="sf_colsOut sf_2cols_2_50"> <div id="ContentPlaceholder_C014_Col01" class="sf_colsIn sf_2cols_2in_50" data-sf-element="Column 2"> </div> </div> </div><div class="sf_cols"> <div class="sf_colsOut sf_1col_1_100"> <div id="ContentPlaceholder_C022_Col00" class="sf_colsIn sf_1col_1in_100"> </div> </div> </div><div class="sf_cols" data-sf-element="Row"> <div class="sf_colsOut sf_2cols_1_50"> <div id="ContentPlaceholder_C015_Col00" class="sf_colsIn sf_2cols_1in_50" data-sf-element="Column 1"> <div > <div class="sfContentBlock sf-Long-text" ><!--<div class="card-grid"> <div class="card" style="border:1px solid #ffff;"> <div class="card__body"> <h3 id="kaelin">William G. Kaelin, Jr., MD</h3> <div class="speaker_header">Nobel Prize-winning Physician </div><em></em></div><em></em> <div class="card__footer"><em></em> <p>Sidney Farber Professor of Medicine Harvard Medical School Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Investigator, Howard Hughes Medical Institute </p> </div> </div> </div>--></div> </div> </div> </div> <div class="sf_colsOut sf_2cols_2_50"> <div id="ContentPlaceholder_C015_Col01" class="sf_colsIn sf_2cols_2in_50" data-sf-element="Column 2"> <div > <div class="sfContentBlock sf-Long-text" ><!--<div style="position:relative;padding-bottom:56.25%;padding-top:30px;height:0;overflow:hidden;width:100%;max-width:100%;max-height:calc(100vh - 64px);margin-top:2%;"><iframe width="100%" height="315" src="https://www.youtube.com/embed/JpvX3CIMhvk?rel=0&modestbranding=1&autoplay=1&mute=1&playlist=JpvX3CIMhvk&loop=1" title="Dr. William Kaelin" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen="" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></div>--></div> </div> </div> </div> </div> <div > <div class="sfContentBlock sf-Long-text" ><!--<div class="space-b-050 space-t-050 space-b-250-m space-t-250-m"></div> <h6><em>The VHL Tumor Suppressor Protein: Insights into Oxygen Sensing and Cancer</em></h6> <p>This keynote address will describe new drugs emerging from studies of the VHL tumor suppressor protein (pVHL), which is usually defective in clear cell renal cell carcinomas (ccRCCs). pVHL forms a ubiquitin ligase that targets the alpha subunits of the HIF transcription factor for proteasomal degradation provided they are prolyl hydroxylated by the oxygen-sensitive EglN (also called PHD) 2-oxoglutarate (2-OG)-dependent dioxygenases. HIF2α promotes ccRCC and HIF1α inhibits ccRCC in preclinical models. An allosteric HIF2α inhibitor has advanced to Phase 3 testing in sporadic ccRCC and was recently approved for the treatment of VHL Disease. Conversely, drugs that stabilize HIF are being developed for the treatment of anemia and ischemic diseases (e.g., heart attack and stroke). Dr. Kaelin's team also recently showed that GPR35 agonists are protective in ischemic models. He will describe their recent efforts to identify new cancer targets based on synthetic lethality and to find protein degraders for “undruggable” oncoproteins. </p> <p><strong>Dr. William Kaelin</strong> is the Sidney Farber Professor of Medicine at Harvard Medical School and Dana-Farber Cancer Institute, Senior Physician in Medicine at Brigham and Women's Hospital and Howard Hughes Medical Institute Investigator. A Nobel Laureate, Dr. Kaelin received the 2019 Nobel Prize in Physiology or Medicine. Dr. Kaelin’s research seeks to understand how, mechanistically, mutations affecting tumor-suppressor genes cause cancer. His laboratory is currently focused on studies of the VHL, RB-1, and p53 biochemical functions of tumor suppressor genes. The team uses genetic and biochemical approaches with both human and mouse cells, including genetically engineered mouse models. He is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, the National Academy of Medicine, the American Society of Clinical Investigation, and the American College of Physicians.</p>--></div> </div><div class="sf_cols"> <div class="sf_colsOut sf_1col_1_100"> <div id="ContentPlaceholder_C023_Col00" class="sf_colsIn sf_1col_1in_100"> <div > <div class="sfContentBlock sf-Long-text" ><div class="space-b-050 space-t-050 space-b-250-m space-t-250-m"></div></div> </div> </div> </div> </div><div class="sf_cols" data-sf-element="Row"> <div class="sf_colsOut sf_2cols_1_50"> <div id="ContentPlaceholder_C008_Col00" class="sf_colsIn sf_2cols_1in_50" data-sf-element="Column 1"> <div > <div class="sfContentBlock sf-Long-text" ><!--<div class="card-grid"> <div class="card" style="border:1px solid #ffff;"> <div class="card__body"> <h3 id="thorp">Holden Thorp, PhD</h3> <div class="speaker_header"><em>Science, </em> Journal Editor-in-Chief </div> </div><em></em> <div class="card__footer"><em></em> <p>Rita Levi-Montalcini Distinguished University Professor, Washington University </p> </div> </div> </div>--></div> </div> </div> </div> <div class="sf_colsOut sf_2cols_2_50"> <div id="ContentPlaceholder_C008_Col01" class="sf_colsIn sf_2cols_2in_50" data-sf-element="Column 2"> <div > <div class="sfContentBlock sf-Long-text" ><!--<div style="position:relative;padding-bottom:56.25%;padding-top:30px;height:0;overflow:hidden;width:100%;max-width:100%;max-height:calc(100vh - 64px);margin-top:2%;"><iframe width="100%" height="315" src="https://www.youtube.com/embed/Om0JWQV06wQ?rel=0&modestbranding=1&autoplay=1&mute=1&playlist=Om0JWQV06wQ&loop=1" title="Dr. Holden Thorp" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen="" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></div>--></div> </div> </div> </div> </div> </div> <div class="sf_cols" data-sf-element="Row"> <div class="sf_colsOut sf_1col_1_100"> <div id="ContentPlaceholder_C004_Col00" class="sf_colsIn sf_1col_1in_100" data-sf-element="Column 1"> <div > <div class="sfContentBlock sf-Long-text" ><!--<div class="space-b-050 space-t-050 space-b-250-m space-t-250-m"></div> <h6><em>Understanding Anti-Science: Why Scientists Should Learn History</em><strong></strong></h6> <p>The COVID pandemic has brought a stark reminder of the difficulties in convincing the public of scientific facts that conflict with their ideology. An examination of the history of anti-science shows that the patterns that obtained during the pandemic were the same as those that occurred during controversies around evolution, smoking, ozone, and climate change. These patterns are driven by politics but also by the dogma within science to remain objective. To prevent similar episodes in the past, the scientific enterprise needs a reckoning about how consensus within science is managed.</p> <p><strong>Dr. Holden Thorp </strong>became Editor-in-Chief of the <em>Science </em>family of journals in October 2019. He joined the Science journals from Washington University, where he was provost from 2013 to 2019 and where he is Rita Levi-Montalcini Distinguished University Professor and holds appointments in both chemistry and medicine. Dr. Thorp joined Washington University after spending three decades at the University of North Carolina at Chapel Hill, where he served as the 10th chancellor from 2008 through 2013. In his research career, Dr. Thorp studied electron-transfer reactions of nucleric acid, developed technology for electronic DNA chips, and cofounded Viamet Pharmaceuticals, which developed VIVJOA (oteseconazole), now approved by the FDA. Dr. Thorp is a fellow of the American Academy of Arts and Sciences, the National Academy of Inventors, and the American Association for the Advancement of Science.</p>--></div> </div> </div> </div> </div> </div> </div> <div class="sf_colsOut interior-layout__aside" style="width: 25%;" data-placeholder-label="Aside"> <div id="ContentPlaceholder_T76CE7C69009_Col03" class="sf_colsIn sf_4cols_4in_25"> <div > <div class="sfContentBlock sf-Long-text" ><h5><span class="quicklinks__icon"><em class="fa-thin fa-calendar-circle-exclamation"></em></span> Important Dates</h5><div style="display:flex;flex-direction:column;justify-content:space-between;"><!-- <div style="margin-bottom:1em;"> <div class="date_container"> <div class="date_cover"> <div class="month_box"> <p>Dec </p> </div> <div class="date_box"> <p>11</p> </div> </div> <div style="flex-basis:80%;"> <p>Abstract Deadline Extended</p> </div> </div> </div> <div style="margin-bottom:1em;"> <div class="date_container"> <div class="date_cover"> <div class="month_box"> <p>Dec </p> </div> <div class="date_box"> <p>15</p> </div> </div> <div style="flex-basis:80%;"> <p>Last day to apply for the ASPET Mentoring Network </p> </div> </div> </div> <div style="margin-bottom:1em;"> <div class="date_container"> <div class="date_cover"> <div class="month_box"> <p>Feb </p> </div> <div class="date_box"> <p>8</p> </div> </div> <div style="flex-basis:80%;"> <p>Registration Discounts End </p> </div> </div> </div> <div style="margin-bottom:1em;"> <div class="date_container"> <div class="date_cover"> <div class="month_box"> <p>Feb</p> </div> <div class="date_box"> <p>22</p> </div> </div> <div style="flex-basis:80%;"> <p>The abstract submission deadline for the poster presentation ends today.</p> </div> </div> </div> <div style="margin-bottom:1em;"> <div class="date_container"> <div class="date_cover" style="width:3.25em !important;"> <div class="month_box"> <p>Apr </p> </div> <div class="date_box"> <p> </p> </div> </div> <div style="flex-basis:80%;"> <p>Online VIP award lectures and division town halls </p> </div> </div> </div>--> <div style="margin-bottom:1em;"><div class="date_container"><div class="date_cover"><div class="month_box"><p>May </p></div><div class="date_box"><p>16-19</p></div></div><div style="flex-basis:80%;"><p>ASPET Annual Meeting in Arlington, VA </p></div></div></div><div style="margin-bottom:1em;"><div class="date_container"><div class="date_cover"><div class="month_box"><p>May</p></div><div class="date_box"><p>19-20</p></div></div><div style="flex-basis:80%;"><p>ADDC/ASPET Colloquium </p></div></div></div><div style="margin-bottom:1em;"><div class="date_container"><div class="date_cover"><div class="month_box"><p>April </p></div><div class="date_box"><p>3-6</p></div></div><div style="flex-basis:80%;"><p>ASPET 2025 Annual Meeting <br />Portland, OR </p></div></div></div><div style="margin-bottom:1em;"><div class="date_container"><div class="date_cover"><div 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Providing a value for 'defaultId' will cover cases where // the string is blank or consists entirely of characters we will strip out function generateHtmlId(str, defaultId) { // sanitize our id value a bit. The html5 spec is /very/ permissive about // what can be in an id (pretty much anything but spaces goes), but strip // out some additional characters in case we're using this as a url fragment var idString = str .trim() .replace(/\s+/g, '-') .replace(/[\.\?\$\/ #&%@,]/g, '') .toLowerCase(); idString = idString || defaultId || ''; // in case str was empty or all special chars // if we have an id conflict, increment until we don't. We could append // some kind of random value, but we want this to produce the same // linkable hash each run var tryCount = 0; var existingElement = document.getElementById(idString); while (existingElement) { tryCount++; existingElement = document.getElementById(idString + '-' + String(tryCount)); } if (tryCount > 0) { idString += '-' + String(tryCount); } return idString; } // xhr helper function xhr(method, url, callback, data) { var _validMethods = ['GET', 'POST', 'HEAD', 'PUT', 'DELETE', 'CONNECT', 'OPTIONS', 'TRACE', 'PATCH'], xhr = new XMLHttpRequest(); if (!method) { console.error('No method provided to xhr'); return false; } method = method.toUpperCase(); if (!_validMethods.includes(method)) { console.error(method + ' is not a valid http request method'); return false; } if (!url) { console.error('No url provided to xhr'); return false; } xhr.onreadystatechange = function () { if (xhr.readyState === XMLHttpRequest.DONE) { if (xhr.status === 200) { if (callback && typeof callback === 'function') { callback(xhr.responseText); } else { console.log(xhr.responseText); } } else { console.error('XHR returned a status of ' + xhr.status); console.log(xhr); } } }; xhr.open(method, url); if (method === 'POST' && data) { xhr.setRequestHeader('Content-Type', 'application/x-www-form-urlencoded'); if (typeof data === 'object') { xhr.send(objectToParameters(data)); } else { xhr.send(data); } } else { xhr.send(); } } /* =toggles * ======== * * a one-to-many class toggler activated on click * * default elements: * <el data-toggle-target="[keyword|selector]" /> * * external toggle interactions * <el data-toggle-exit="esc outside" /> */ var toggles = (function () { var toggleList = [], togglePrototype = { origin: null, targets: [], activeClass: 'is-active', deactivateOnEsc: false, deactivateOnOutside: false, useFragments: false, // make toggle go activate: function activate(force) { _.forEach([this.origin].concat(this.targets), function (el, i) { if (typeof force === 'boolean') { el.classList.toggle(this.activeClass, force); } else { el.classList.toggle(this.activeClass); } // if this is the origin, set control state if (i === 0) { el.setAttribute('aria-expanded', (el.classList.contains(this.activeClass)).toString()); // if this is a toggle, set aria hidden state } else { el.setAttribute('aria-hidden', (!el.classList.contains(this.activeClass)).toString()); } }.bind(this)); // focus first target as a convenience to kb/sr users if (this.origin.classList.contains(this.activeClass) && this.targets.length > 0) { this.targets[0].focus(); } // write url fragment, if applicable if (this.useFragments && this.origin.id) { if (this.origin.classList.contains(this.activeClass)) { window.history.replaceState(null, '', '#' + encodeURIComponent(this.origin.id)); } else { window.history.replaceState(null, '', window.location.href.split('#')[0]); } } if (typeof this.onActivate === 'function') { this.onActivate(this); } return this; }, // get targets, generate a11y attributes, and add event listeners init: function init() { this.targets = toArray(this.targets); // set up ids this.origin.id = this.origin.id || generateHtmlId(this.origin.textContent.substr(0, 24), 'toggle'); _.forEach(this.targets, function generateTargetId(target) { target.id = target.id || generateHtmlId(this.origin.textContent.substr(0, 24) + '-pane', 'pane'); }.bind(this)); // set initial a11y attributes this.origin.setAttribute('role', 'button'); this.origin.setAttribute('aria-expanded', (this.origin.classList.contains(this.activeClass)).toString()); this.origin.setAttribute('aria-controls', this.targets[0].id); _.forEach(this.targets, function linkTargetToOrigin(target) { target.setAttribute('aria-labelledby', this.origin.id); target.setAttribute('aria-hidden', (!this.origin.classList.contains(this.activeClass)).toString()); }.bind(this)); // make toggle focusable if it isn't a focusable element by default this.origin.setAttribute('tabindex', '0'); // allow programmatic focus on first target content element if (this.targets.length > 0) { this.targets[0].setAttribute('tabindex', '-1'); } // bind listeners this.origin.addEventListener('click', function (ev) { ev.preventDefault(); this.activate(); }.bind(this)); this.origin.addEventListener('keydown', function (ev) { // bind spacebar and return in case we're not using a native // button element that includes these interactions implicitly if (ev.keyCode === 13 || ev.keyCode === 32) { ev.preventDefault(); this.activate(); } }.bind(this)); if (typeof this.onInit === 'function') { this.onInit(this); } return this; }, // optional callbacks onActivate: null, onInit: null }; // private: parses a target string and returns a matching array function findTargets(el) { var targetString = el.getAttribute('data-toggle-target'); if (!targetString) { return []; } else if (targetString === 'next') { return [el.nextElementSibling]; } else if (targetString === 'parent') { return [el.parentNode]; } else if (targetString === 'parentparent') { return [el.parentNode.parentNode]; } else if (targetString === 'parentnext') { return [el.parentNode.nextElementSibling]; } else if (targetString === 'parentparentnext') { return [el.parentNode.parentNode.nextElementSibling]; } return toArray(document.querySelectorAll(targetString)); } // public: make node or nodeList toggleable function add(els, options) { options = options || {}; els = toArray(els); _.forEach(els, function (el) { var toggle = _.assign(Object.create(togglePrototype), { origin: el }, options); toggleList.push(toggle); toggle.init(); }); return list(); } // public: returns an array of all toggles on the page function list() { return toggleList; } // public: returns all toggle objects whose origins match a given css selector function find(selector) { var result = []; _.forEach(list(), function (toggle) { if (toggle.origin.matches(selector)) { result.push(toggle); } }); return result; } // public: returns a single toggle object whose origin matches a given css selector function get(selector) { var result = null; _.forEach(list(), function (toggle) { if (toggle.origin.matches(selector)) { result = toggle; return false; } }); return result; } // public: initialize by adding default elements function init() { _.forEach(document.querySelectorAll('[data-toggle-target]'), function addNewToggle(el) { var options = { targets: findTargets(el), deactivateOnEsc: (/\besc\b/.test(el.getAttribute('data-toggle-exit'))), deactivateOnOutside: (/\boutside\b/.test(el.getAttribute('data-toggle-exit'))), useFragments: Boolean(el.getAttribute('data-toggle-fragment')), }; add(el, options); }); // open any toggles that match url fragment if (window.location.hash) { var urlFragment = decodeURIComponent(window.location.hash.substr(1)); _.forEach(list(), function matchGroupFragment(group) { _.forEach([group.origin].concat(group.targets), function matchElementFragment(el) { if (el.id === urlFragment) { group.activate(true); } }); }); } // add global close listeners document.documentElement.addEventListener('keyup', function (ev) { if (ev.keyCode === 27) { _.forEach(list(), function (toggle) { if (toggle.deactivateOnEsc) { toggle.activate(false); } }); } }); document.body.addEventListener('click', function (ev) { _.forEach(list().filter(function (toggle) { return toggle.deactivateOnOutside; }), function (toggle) { var deactivate = true, els = [toggle.origin].concat(toggle.targets); for (var i = els.length - 1; i >= 0; i--) { if (els[i] === ev.target || els[i].contains(ev.target)) { deactivate = false; break; } } if (deactivate) { toggle.activate(false); } }); }); } return { add: add, list: list, find: find, get: get, init: init }; }()); /* =tabs * ===== * * a class switcher wherein only one element (or pair of elements) * may be active at a time * * default elements: * <el class="tabs [is-automated]?"> * <el class="tabs__tab" /> * <el class="tabs__pane" /> * </el> */ var tabs = (function () { var tabGroupList = [], tabGroupPrototype = { // preferences automated: false, slideDuration: 5000, useFragments: false, // calculated attributes active: 0, count: 0, // elements container: null, tabs: null, panes: null, nextTriggers: null, previousTriggers: null, playTriggers: null, pauseTriggers: null, // default (overrideable) selectors used in init() containerSelector: '.tabs', tabSelector: '.tabs__tab', paneSelector: '.tabs__pane', nextSelector: '.tabs__next', previousSelector: '.tabs__previous', playSelector: '.tabs__play', pauseSelector: '.tabs__pause', // classes activeClass: 'is-active', lastActiveClass: 'is-last-active', nextClass: 'is-next', previousClass: 'is-previous', initClass: 'is-enhanced', playingClass: 'is-playing', // utility timer: null, changeTo: function changeTo(index, interruptTimer, isFirstLoad) { if (index === 'next') { index = this.getNextIndex(); } else if (index === 'previous') { index = this.getPreviousIndex(); } else if (typeof index !== 'number' || index < 0 || index >= this.count) { console.warn('given index not recognized'); return this; } if (interruptTimer && this.automated) { this.pause(); } // reset state classes to blank slate _.forEach(this.tabs.concat(this.panes), function (el) { el.classList.remove(this.activeClass); el.classList.remove(this.lastActiveClass); el.classList.remove(this.nextClass); el.classList.remove(this.previousClass); }.bind(this)); // reset aria attributes to defaults _.forEach(this.tabs, function (tab) { tab.setAttribute('aria-selected', 'false'); }.bind(this)); _.forEach(this.panes, function (pane) { pane.setAttribute('aria-hidden', 'true'); }.bind(this)); // mark the tab we're changing /from/ for the purposes of animation if (this.active !== index) { if (this.tabs[this.active]) { this.tabs[this.active].classList.add(this.lastActiveClass); } if (this.panes[this.active]) { this.panes[this.active].classList.add(this.lastActiveClass); } } // make it so this.active = index; // add all state classes and aria states if (this.tabs[index]) { this.tabs[index].classList.add(this.activeClass); this.tabs[index].setAttribute('aria-selected', 'true'); } if (this.panes[index]) { this.panes[index].classList.add(this.activeClass); this.panes[index].setAttribute('aria-hidden', 'false'); } if (this.tabs[this.getNextIndex()]) { this.tabs[this.getNextIndex()].classList.add(this.nextClass); } if (this.panes[this.getNextIndex()]) { this.panes[this.getNextIndex()].classList.add(this.nextClass); } if (this.tabs[this.getPreviousIndex()]) { this.tabs[this.getPreviousIndex()].classList.add(this.previousClass); } if (this.panes[this.getPreviousIndex()]) { this.panes[this.getPreviousIndex()].classList.add(this.previousClass); } // handle fragment ids // no need to do this on initial page load, because either it's loading the default // (first) tab or we're loading from an existing fragment specifier if (this.useFragments && this.tabs[index] && this.tabs[index].id && !isFirstLoad) { window.history.replaceState(null, '', '#' + encodeURIComponent(this.tabs[index].id)); } // focus first element inside selected pane for a better screen-reader experience if (!isFirstLoad && !this.automated && this.panes[index] && this.panes[index].children.length > 0) { this.panes[index].children[0].setAttribute('tabindex', '-1'); this.panes[index].children[0].focus(); } if (interruptTimer && this.automated) { this.play(); } if (typeof this.onChange === 'function') { this.onChange(this); } return this; }, play: function play() { this.container.classList.add(this.playingClass); if (this.timer > 0) { return false; } this.timer = setInterval(function () { this.changeTo('next'); }.bind(this), this.slideDuration); if (typeof this.onPlay === 'function') { this.onPlay(this); } return this; }, pause: function pause() { this.container.classList.remove(this.playingClass); clearInterval(this.timer); this.timer = 0; if (typeof this.onPause === 'function') { this.onPause(this); } return this; }, getNextIndex: function getNextIndex() { return (this.active + 1) % this.count; }, getPreviousIndex: function getPreviousIndex() { return this.active <= 0 ? this.count - 1 : this.active - 1; }, generateTabIds: function generateTabIds() { _.forEach(this.tabs, function generateTabId(el) { if (el.id) return false; // skip if an id has been provided for us el.id = generateHtmlId(el.textContent, 'tab'); }); }, generateAriaAttributes: function generateAriaAttributes() { for (var i = 0; i < this.count; i++) { // make sure each pane also has an id // if an id is not present, generate from the associated tab id if (this.tabs[i] && this.panes[i]) { if (!this.panes[i].id) { this.panes[i].id = this.tabs[i].id + '-pane'; } // make sure each tab is linked to its associated pane if (this.tabs[i].tagName.toLowerCase() == 'a') { this.tabs[i].href = '#' + this.panes[i].id; } this.tabs[i].setAttribute('aria-controls', this.panes[i].id); // make sure each pane is labeled by its associated tab this.panes[i].setAttribute('aria-labelledby', this.tabs[i].id); } } }, init: function init() { // default elements this.tabs = toArray(this.tabs || getElementsWithoutParent(this.tabSelector, this.containerSelector, this.container)); this.panes = toArray(this.panes || getElementsWithoutParent(this.paneSelector, this.containerSelector, this.container)); this.nextTriggers = toArray(this.nextTriggers || getElementsWithoutParent(this.nextSelector, this.containerSelector, this.container)); this.previousTriggers = toArray(this.previousTriggers || getElementsWithoutParent(this.previousSelector, this.containerSelector, this.container)); this.playTriggers = toArray(this.playTriggers || getElementsWithoutParent(this.playSelector, this.containerSelector, this.container)); this.pauseTriggers = toArray(this.pauseTriggers || getElementsWithoutParent(this.pauseSelector, this.containerSelector, this.container)); // get final tabs count this.count = Math.max(this.tabs.length, this.panes.length); // generate tab ids for a11y and fragment links this.generateTabIds(); // link tabs and panes in markup for screen reader benefit this.generateAriaAttributes(); // apply count as container class to help css sizing this.container.classList.add('tabs--' + String(this.count)); // attach event listeners _.forEach(this.tabs, function (tab, index) { tab.setAttribute('tabindex', '0'); tab.addEventListener('click', function (ev) { ev.preventDefault(); this.changeTo(index, true); }.bind(this)); tab.addEventListener('keydown', function (ev) { if (ev.keyCode === 13 || ev.keyCode === 32) { ev.preventDefault(); this.changeTo(index, true); } }.bind(this)); }.bind(this)); _.forEach(this.nextTriggers, function (el) { el.addEventListener('click', function (ev) { ev.preventDefault(); this.changeTo('next', true); }.bind(this)); }.bind(this)); _.forEach(this.previousTriggers, function (el) { el.addEventListener('click', function (ev) { ev.preventDefault(); this.changeTo('previous', true); }.bind(this)); }.bind(this)); _.forEach(this.pauseTriggers, function (el) { el.addEventListener('click', function (ev) { ev.preventDefault(); this.pause(); }.bind(this)); }.bind(this)); _.forEach(this.playTriggers, function (el) { el.addEventListener('click', function (ev) { ev.preventDefault(); this.play(); }.bind(this)); }.bind(this)); // automated slideshows get paused on mouseover if (this.automated) { this.container.addEventListener('mouseenter', this.pause.bind(this)); this.container.addEventListener('mouseleave', this.play.bind(this)); } // if we have a fragment specifier, use it; otherwise, the first tab is open by default if (this.useFragments && window.location.hash) { var fragment = decodeURIComponent(window.location.hash.substr(1)); for (var i = 0; i < this.tabs.length; i++) { if (this.tabs[i].id === fragment) { this.active = i; break; } } } this.changeTo(this.active, false, true); if (this.automated) { this.play(); } if (typeof this.onInit === 'function') { this.onInit(this); } this.container.classList.add(this.initClass); return this; }, // optional callbacks onChange: null, onPlay: null, onPause: null, onInit: null }; // public: make node or nodeList into tab groups function add(els, options) { options = options || {}; els = toArray(els); _.forEach(els, function (el) { var tabGroup = _.assign(Object.create(tabGroupPrototype), { container: el }, options); tabGroupList.push(tabGroup); tabGroup.init(); }); return list(); } // public: returns an array of all tab groups on the page function list() { return tabGroupList; } // public: returns all tab groups whose containers match a given css selector function find(selector) { var result = []; _.forEach(list(), function (tabGroup) { if (tabGroup.container.matches(selector)) { result.push(tabGroup); } }); return result; } // public: returns a single tab group whose container matches a given css selector function get(selector) { var result = null; _.forEach(list(), function (tabGroup) { if (tabGroup.container.matches(selector)) { result = tabGroup; return false; } }); return result; } // public: initialize by adding default elements function init() { _.forEach(toArray(document.getElementsByClassName('tabs')), function addTabsContainer(container) { add(container, { automated: container.matches('.tabs--automated'), useFragments: container.matches('.tabs--use-fragments'), }); }); } return { add: add, list: list, find: find, get: get, init: init }; }()); /* =shared height elements * ======================= * * match minimum heights across disparate elements * * usage: * <el data-height-group="groupname" /> */ var sharedHeights = (function () { var heightGroups = {}; // public: update all shared-height elements function update() { var g, thisGroup, heights, maxHeight; function resetHeight(el) { el.style.minHeight = 0; heights.push(el.offsetHeight); } function applyHeight(el) { el.style.minHeight = maxHeight + 'px'; } for (g in heightGroups) { if (heightGroups.hasOwnProperty(g)) { thisGroup = heightGroups[g]; heights = []; _.forEach(thisGroup, resetHeight); maxHeight = Math.max.apply(null, heights); _.forEach(thisGroup, applyHeight); } } } // public: add shared-height functionality to a node or nodelist function add(els, groupName) { _.forEach(toArray(els), function (el) { var group = groupName || el.getAttribute('data-height-group'); if (!group) { console.warn('No group specified for shared-height element'); return false; } heightGroups[group] = heightGroups[group] || []; heightGroups[group].push(el); }); return list(); } // public: return heightGroups object function list() { return heightGroups; } // public: initialize with default elements function init() { add(document.querySelectorAll('[data-height-group]')); update(); } var debouncedUpdate = _.debounce(update, 75); window.addEventListener('resize', debouncedUpdate); window.addEventListener('load', debouncedUpdate); return { add: add, list: list, update: update, init: init }; }()); /* =waypoints * ========== * * a scrolling waypoint-based class switcher, for when skrollr is overkill * * default elements: * <el data-waypoints="waypoint[ persist]?: class" /> * where waypoint is a number and a unit of measurement (%, px, em). * multiple waypoints may be separated by commas */ var waypoints = (function () { var waypointElementList = [], waypointElementPrototype = { el: null, waypoints: [], init: function () { var configString = this.el.getAttribute('data-waypoints'); if (!configString) { return false; } _.forEach(configString.split(','), function (config) { var configParts = config.split(':'), val, cl, unit, persist = false, waypoint; try { val = configParts[0].trim(); cl = configParts[1].trim(); if (val.substr(-7) === 'persist') { persist = true; val = val.slice(0, -7).trim(); } unit = val.replace(/\d|,/g, '') || '%'; val = parseFloat(val); if (!cl || isNaN(val) || typeof val !== 'number') { throw 'Bad config'; } waypoint = _.assign(Object.create(waypointPrototype), { unit: unit, val: val, cl: cl, persistent: persist }); this.waypoints.push(waypoint); } catch (e) { console.warn('Bad inline configuration provided to waypoints in element ', this.el, ' at waypoint ', configParts[0]); } }.bind(this)); } }, waypointPrototype = { val: 50, unit: '%', cl: '', persistent: false }; function scrollListener() { var viewportHeight = document.documentElement.clientHeight; _.forEachRight(waypointElementList, function (waypointElement, elementIndex) { var offset = waypointElement.el.getBoundingClientRect().top - viewportHeight, scroll = window.scrollY; if (offset < 0 && window.scrollY > 0) { _.forEachRight(waypointElement.waypoints, function (waypoint, waypointIndex) { var test = false; switch (waypoint.unit) { case '%': var percentage = -offset / waypointElement.el.offsetHeight * 100; test = percentage > waypoint.val; break; case 'em': var elementFontSize = parseFloat(getComputedStyle(waypointElement.el).fontSize); test = -offset > elementFontSize * waypoint.val; break; case 'rem': var documentFontSize = parseFloat(getComputedStyle(document.body).fontSize); test = -offset > documentFontSize * waypoint.val; break; case 'vh': test = -offset > viewportHeight / 100 * waypoint.val; break; default: // px test = -offset > waypoint.val; break; } if (test) { waypointElement.el.classList.add(waypoint.cl); // no need to continue tracking persistent elements after activation if (waypoint.persistent) { waypointElement.waypoints.splice(waypointIndex, 1); } } else { waypointElement.el.classList.remove(waypoint.cl); } }); } else { _.forEach(waypointElement.waypoints, function (waypoint) { waypointElement.el.classList.remove(waypoint.cl); }); } // prune inactive waypoint elements if (waypointElement.waypoints.length === 0) { waypointElementList.splice(elementIndex, 1); } }); } // public: add elements to scroll tracking function add(els, options) { options = options || {}; els = toArray(els); _.forEach(els, function (el) { var waypointElement = _.assign(Object.create(waypointElementPrototype), { el: el, waypoints: [] }, options); waypointElementList.push(waypointElement); waypointElement.init(); }); return list(); } // public: returns an array of all elements currently tracked by waypoints function list() { return waypointElementList; } // public: track default elements and add scroll listener function init() { _.forEach(document.querySelectorAll('[data-waypoints]'), add); // do initial pass scrollListener(); // debounce function and listen window.addEventListener('scroll', _.throttle(scrollListener, 150)); } return { init: init, list: list, add: add }; }()); /* =social share links * =================== * * unobtrusive 'share' buttons that don't use too much bandwidth or create * privacy concerns * * default elements: * <div data-share-to="facebook twitter google linkedin reddit pinterest tumblr email"></div> */ var sharing = (function () { // glean some default parameters from the page var defaultOptions = { services: 'facebook twitter linkedin email', url: (function () { var link = document.querySelector('link[rel="canonical"]'), og = document.querySelector('meta[property="og:url"]'); if (link) { return link.getAttribute('href'); } else if (og) { return og.getAttribute('content'); } return window.location.href; })(), title: (function () { var og = document.querySelector('meta[property="og:title"]'); if (og) { return og.getAttribute('content'); } return document.title; })(), abstract: (function () { var og = document.querySelector('meta[property="og:description"]'), meta = document.querySelector('meta[name="description"]'); if (og) { return og.getAttribute('content'); } else if (meta) { return meta.getAttribute('content'); } return null; })(), thumbnail: (function () { var og = document.querySelector('meta[property="og:image"]'), apple = document.querySelector('link[rel="apple-touch-icon-precomposed"]'); if (og) { return og.getAttribute('content'); } else if (apple) { return apple.getAttribute('href'); } return null; })(), cite: (function () { var og = document.querySelector('meta[property="og:site_name"]'), link = document.querySelector('link[rel="start"][title]'); if (og) { return og.getAttribute('content'); } else if (link) { return link.getAttribute('title'); } return null; })() }; // generate services and their params using passed-in options data function generateServiceData(options) { options = options || {}; return { facebook: { name: 'Facebook', icon: 'fab fa-facebook-square', url: 'https://www.facebook.com/sharer/sharer.php', params: [ { name: 'u', value: options.url }, { name: 'title', value: options.title }, { name: 'quote', value: options.text }, { name: 'description', value: options.abstract }, { name: 'caption', value: options.cite }, { name: 'picture', value: options.thumbnail } ] }, twitter: { name: 'Twitter', icon: 'fab fa-twitter-square', url: 'https://twitter.com/intent/tweet', params: [ { name: 'url', value: options.url }, { name: 'text', value: options.text } ] }, google: { name: 'Google Plus', icon: 'fab fa-google-plus-square', url: 'https://plus.google.com/share', params: [ { name: 'url', value: options.url } ] }, linkedin: { name: 'LinkedIn', icon: 'fab fa-linkedin', url: 'https://www.linkedin.com/shareArticle', params: [ { name: 'url', value: options.url }, { name: 'mini', value: 'true' }, { name: 'title', value: options.title }, { name: 'summary', value: options.abstract }, { name: 'source', value: options.cite } ] }, reddit: { name: 'Reddit', icon: 'fab fa-reddit-square', url: 'https://www.reddit.com/submit', params: [ { name: 'url', value: options.url }, { name: 'title', value: options.title } ] }, pinterest: { name: 'Pinterest', icon: 'fab fa-pinterest-square', url: 'https://pinterest.com/pin/create/button/', params: [ { name: 'url', value: options.url }, { name: 'media', value: options.thumbnail }, { name: 'description', value: options.title } ] }, tumblr: { name: 'Tumblr', icon: 'fab fa-tumblr-square', url: 'https://www.tumblr.com/widgets/share/tool', params: [ { name: 'canonicalUrl', value: options.url }, { name: 'title', value: options.title }, { name: 'caption', value: options.abstract } ] }, email: { name: 'Email', icon: 'fas fa-envelope-square', url: 'mailto:', params: [ { name: 'subject', value: options.title }, { name: 'body', value: options.url + '\n' + (options.text || '') }, ] } }; } // populate our container with share buttons function generateMarkup(el, options) { var serviceData = generateServiceData(options), button = document.createElement('a'); button.setAttribute('target', '_blank'); button.className = 'share-buttons__button'; _.forEach(options.services.split(/\s+/), function (service) { if (!service) return false; var thisButton = button.cloneNode(true), thisData = serviceData[service]; if (!thisData) return false; thisButton.innerHTML = '<span class="' + thisData.icon + '"></span>'; thisButton.setAttribute('title', 'Share via ' + thisData.name); thisButton.href = thisData.url + '?' + thisData.params.map(function (param) { if (param.value) { return encodeURIComponent(param.name) + '=' + encodeURIComponent(param.value); } return null; }).filter(function (param) { return !!param; }).join('&'); el.appendChild(thisButton); }); } // add share buttons to a container function add(els, options) { els = toArray(els); options = options || {}; _.forEach(els, function (el) { // look for 'data-share-to' attribute on container if no services are passed var declaredServices = {}; if (!options.services && el.getAttribute('data-share-to')) { declaredServices.services = el.getAttribute('data-share-to'); } generateMarkup(el, _.assign(defaultOptions, options, declaredServices)); }); } // initialize with default elements function init() { add(document.querySelector('[data-share-to]')); } return { init: init, add: add }; })(); /* =truncators * =========== * * truncate containers to number of lines, fixed height, and so on * * usage: * <div data-truncate-to="5 lines" data-truncate-text="Show More"></div> * <div data-truncate-to="100px"></div> * <div data-truncate-to="2em"></div> * <div data-truncate-to="3 items"></div> * etc. */ var truncators = (function () { var buttonPrototype = document.createElement('button'), truncatorList = [], truncatorPrototype = { container: null, button: null, buttonText: "Show More", expandedButtonText: "Show Less", limit: null, limitUnit: null, isRepeatable: false, isTruncated: false, init: function () { var configString = this.container.getAttribute('data-truncate-to'); // parse units if ((!this.limit || !this.limitUnit) && configString) { this.limit = parseInt((configString.match(/^\d+/) || [''])[0], 10); this.limitUnit = (configString.match(/[a-z]+$/i) || [''])[0].trim(); } if (!this.limit || isNaN(this.limit) || !this.limitUnit) { console.error("Bad limit or unit config provided to following truncator:", this.container); return; } if (!this.button) { this.button = buttonPrototype.cloneNode(true); } this.truncate(); this.button.addEventListener('click', function (ev) { if (this.isTruncated) { this.expand(); } else { this.truncate(); } }.bind(this)); }, truncate: function () { var normalizedLimit, buttonSuffix = ''; // if we're limiting by items, we can hide items instead of limiting pixel height if (this.limitUnit === 'item' || this.limitUnit === 'items') { var items = this.container.children, hideCount = items.length - this.limit; // do no truncation if there aren't enough items if (hideCount <= 0) { return; } for (var i = this.limit; i < items.length; i++) { items[i].style.display = 'none'; } if (hideCount > 0) { buttonSuffix = ' (' + hideCount + (hideCount > 1 ? ' items' : ' item') + ')'; } // if we're not limiting by items, we'll need to calculate a max-height } else { this.container.style.overflow = 'hidden'; switch (this.limitUnit) { case '%': normalizedLimit = this.container.clientHeight * this.limit / 100; break; case 'em': // compute font size of element in px and multiply normalizedLimit = parseFloat(getComputedStyle(this.container).fontSize) * this.limit; break; case 'rem': // compute font size of body in px and multiply normalizedLimit = parseFloat(getComputedStyle(document.body).fontSize) * this.limit; break; case 'vh': // take a percentage of viewport height normalizedLimit = document.documentElement.clientHeight * this.limit / 100; break; case 'vw': // take a percentage of viewport width normalizedLimit = document.documentElement.clientWidth * this.limit / 100; break; case 'line': case 'lines': // calculate pixel height of a line and multiply (function (container, limit) { var testEl = document.createElement('div'), lineHeight; testEl.textContent = 'A'; container.insertBefore(testEl, container.firstElementChild); lineHeight = testEl.offsetHeight; container.removeChild(testEl); normalizedLimit = lineHeight * limit; })(this.container, this.limit); break; default: // px normalizedLimit = this.limit; break; } this.container.style.maxHeight = normalizedLimit + 'px'; } this.button.textContent = this.buttonText + buttonSuffix; this.container.parentNode.insertBefore(this.button, this.container.nextElementSibling); this.isTruncated = true; }, expand: function () { if (this.limitUnit === 'item' || this.limitUnit === 'items') { _.forEach(this.container.children, function (item) { item.style.display = ''; }); } else { this.container.style.overflow = ''; this.container.style.maxHeight = ''; } if (this.isRepeatable) { this.button.textContent = this.expandedButtonText; } else { this.button.parentNode.removeChild(this.button); } this.isTruncated = false; } }; buttonPrototype.setAttribute('type', 'button'); buttonPrototype.className = 'truncator-expand'; function add(els, options) { els = toArray(els); options = options || {}; _.forEach(els, function (el) { var truncator = _.assign(Object.create(truncatorPrototype), {container: el}, options); truncatorList.push(truncator); truncator.init(); }); } function init() { add(document.querySelectorAll('[data-truncate-to]')); } return { init: init, add: add }; })(); /* =horizontal scrollers * ===================== * * Add controls for horizontal scrollers * * <section class="horizontal [horizontal--loop]?"> * <div class="horizontal__scroller"> * <div class="horizontal__contents"> * <div class="horizontal__item"> ... </div> * ... * </div> * </div> * </setion> */ var horizontalScrollers = (function () { var scrollers = [], scrollerPrototype = { loop: false, el: null, scrollEl: null, contentWrapper: null, contentEls: null, leftButton: null, rightButton: null, atStartClass: 'horizontal--is-at-start', atEndClass: 'horizontal--is-at-end', margin: 20, /* * Initialize this scroller, create buttons, and bind listeners */ init: function init(container) { this.el = container; this.scrollEl = container.querySelector('.horizontal__scroller'); if (!this.scrollEl) { throw new Error('Expected scroller wrapper for horizontal scroller'); } this.contentWrapper = container.querySelector('.horizontal__content'); if (!this.contentWrapper) { throw new Error('Expected inner container for horizontal scroller'); } this.contentEls = toArray(this.contentWrapper.children); if (this.contentEls.length === 0) { throw new Error('Expected inner contents for horizontal scroller'); } this.leftButton = this.createButton('left'); this.leftButton.addEventListener('click', this.pageLeft.bind(this)); this.rightButton = this.createButton('right'); this.rightButton.addEventListener('click', this.pageRight.bind(this)); if (!this.loop) { const throttledDetectEdges = _.throttle(this.detectEdges.bind(this), 150); this.scrollEl.addEventListener('scroll', throttledDetectEdges); window.addEventListener('resize', throttledDetectEdges); this.detectEdges(); setTimeout(this.detectEdges.bind(this), 1000); window.addEventListener('load', this.detectEdges.bind(this)); } }, /* * Detects whether the scrollable area is at its very start or end * and applies css classes to match * * Throttle this function and use it as an event handler */ detectEdges: function detectEdges(ev) { if (this.loop) return; const pageSize = this.scrollEl.clientWidth; const contentSize = this.contentWrapper.scrollWidth; if (this.scrollEl.scrollLeft < this.margin) { this.el.classList.add(this.atStartClass); } else { this.el.classList.remove(this.atStartClass); } if (this.scrollEl.scrollLeft > contentSize - pageSize - this.margin) { this.el.classList.add(this.atEndClass); } else { this.el.classList.remove(this.atEndClass); } }, /* * Scroll this horizontal scroller to the very start */ scrollToStart: function scrollToStart() { this.scrollEl.scrollLeft = 0; }, /* * Scroll this horizontal scroller to the far end */ scrollToEnd: function scrollToEnd() { const pageSize = this.scrollEl.clientWidth; const contentSize = this.contentWrapper.scrollWidth; this.scrollEl.scrollLeft = contentSize - pageSize; }, /* * Scroll this area one page left, where a "page" is the width of * the visible area */ pageLeft: function pageLeft() { const pageSize = this.scrollEl.clientWidth; const currentOffset = this.scrollEl.scrollLeft; const targetOffset = Math.max(currentOffset - pageSize, 0); const nearestEl = this.getNearestContentEl(targetOffset); if (this.loop && currentOffset < this.margin) { this.scrollToEnd(); } else { this.scrollEl.scrollLeft = this.contentEls[nearestEl].offsetLeft; } }, /* * Scroll this area one page right, where a "page" is the width of * the visible area */ pageRight: function pageRight() { var pageSize = this.scrollEl.clientWidth; const contentSize = this.contentWrapper.scrollWidth; const currentOffset = this.scrollEl.scrollLeft; const maxOffset = contentSize - pageSize; const targetOffset = Math.min(currentOffset + pageSize, maxOffset); const nearestEl = this.getNearestContentEl(targetOffset); if (this.loop && currentOffset > maxOffset - this.margin) { this.scrollToStart(); } else if (targetOffset === maxOffset || this.contentEls.length <= nearestEl + 1) { this.scrollEl.scrollLeft = targetOffset; } else { this.scrollEl.scrollLeft = this.contentEls[nearestEl + 1].offsetLeft; } }, /* * Create a left or right control button and append it to this * scroller's container */ createButton: function createButton(dir) { const result = document.createElement('button'); result.setAttribute('type', 'button'); result.className = 'horizontal__control horizontal__control--' + dir; result.innerHTML = `<i class="fa-light fa-chevron-${dir}" title="Scroll ${dir}"></i>`; this.el.appendChild(result); return result; }, /* * Given a pixel offset from the left side of this scroller, returns * the element that lies directly underneath it. If that offset would * lie on a gap instead, returns the element to the left of the gap */ getNearestContentEl: function getNearestContentEl(scrollDistance) { for (let i = 0; i < this.contentEls.length; ++i) { if (this.contentEls[i].offsetLeft > scrollDistance) { return i > 0 ? i - 1 : 0; } } return 0; }, }; // public: return a list of scrolling sections tracked by this module function list() { return scrollers; } // public: add this module's functionality to a container element // see module comment for expected structure function add(container, options) { try { const scroller = Object.assign(Object.create(scrollerPrototype), (options || {})); scroller.init(container); scrollers.push(scroller); } catch (e) { console.error(e); } } // public: initialize this module function init() { _.forEach(document.querySelectorAll('.horizontal'), function (container) { add(container, { loop: container.classList.contains('horizontal--loop'), }); }); } return { add: add, list: list, init: init, }; }()); /* =misc * ===== * * miscellaneous enhancements that aren't large enough to justify a module */ var misc = (function () { var exports = Object.create(null); // mobile menu toggle exports.addMobileMenuToggle = function addMobileMenuToggle() { var inactiveClass = 'mobile-menu-was-open'; toggles.add(document.getElementsByClassName('page-header__toggle'), { targets: toArray(document.querySelectorAll('body, .page-header__content')), activeClass: 'mobile-menu-is-open', deactivateOnEsc: true, onActivate: function (toggle) { // add an inactive class only after the menu has been opened and then closed if (!toggle.origin.classList.contains(toggle.activeClass)) { _.forEach([toggle.origin].concat(toggle.targets), function (el) { el.classList.add(inactiveClass); }); } else { _.forEach([toggle.origin].concat(toggle.targets), function (el) { el.classList.remove(inactiveClass); }); } } }); }; // subnav toggles for mobile drilldown exports.addNavDrilldownButtons = function addNavDrilldownButtons() { var toggle = document.createElement('button'); toggle.className = 'header-nav__toggle'; toggle.setAttribute('type', 'button'); toggle.setAttribute('data-toggle-target', 'next'); toggle.innerHTML = 'Expand subnavigation for previous item'; _.forEach(document.querySelectorAll('.header-nav a + ul'), function (sublist) { sublist.parentNode.insertBefore(toggle.cloneNode(true), sublist); }); }; // allow visual focus and selection indicators of input labels exports.focusInputLabels = function focusInputLabels() { _.forEach(document.querySelectorAll('label[for]'), function (label) { var input = document.getElementById(label.getAttribute('for')); // track search container for disclosure search only var searchContainer = null; if (label.classList.contains('header-search__label')) { searchContainer = document.querySelector('.header-search'); } if (input) { input.addEventListener('focus', function (ev) { label.classList.add('is-focused'); if (searchContainer) { searchContainer.classList.add('is-focused'); } }); input.addEventListener('blur', function (ev) { label.classList.remove('is-focused'); if (searchContainer) { searchContainer.classList.remove('is-focused'); } }); if (input.type.toLowerCase() === 'radio' || input.type.toLowerCase() === 'checkbox') { input.addEventListener('change', function (ev) { if (input.checked) { label.classList.add('is-selected'); } else { label.classList.remove('is-selected'); } }); } // trigger 'change' event manually in order to populate highlight states on page load if ("createEvent" in document) { var ev = document.createEvent("HTMLEvents"); ev.initEvent("change", false, true); input.dispatchEvent(ev); } else { input.fireEvent("onchange"); } } }); }; // add utility classes to form inputs // this makes dynamic labels possible, for example exports.addInputUtilityClasses = function addInputUtilityClasses() { var inputs = toArray(document.getElementsByTagName('input')) .filter(isTextInput) .concat(toArray(document.getElementsByTagName('textarea'))); var currentContentClass = 'has-content'; var pastContentClass = 'did-have-content'; _.forEach(inputs, function addClassesToInput(input) { var hasContainedContent = false; // initial state if (input.value) { input.classList.add(currentContentClass); hasContainedContent = true; } // changes input.addEventListener('input', function (ev) { if (input.value) { hasContainedContent = true; input.classList.remove(pastContentClass); input.classList.add(currentContentClass); } else { input.classList.remove(currentContentClass); if (hasContainedContent) { input.classList.add(pastContentClass); } } }); }); }; var isTextInput = (function () { var textInputTypes = ['color', 'date', 'email', 'number', 'password', 'search', 'tel', 'text', 'time', 'url']; return function isTextInput(el) { return textInputTypes.includes(el.getAttribute('type')); }; })(); /* * Keyboard submenu accessibility */ exports.dropdownKeyboardNav = function dropdownKeyboardNav() { const activeClass = 'is-focused'; const mainNavLinks = Array.from(document.querySelectorAll('.header-nav > ul > li > a')); let currentDropdown; // open dropdowns on spacebar/downarrow mainNavLinks.forEach(function (link) { link.addEventListener('keydown', function (ev) { if (['ArrowDown', 'Space'].indexOf(ev.code) > -1) { ev.preventDefault(); const dropdown = this.parentNode.querySelector('ul'); if (!dropdown) return; dropdown.classList.add(activeClass); dropdown.querySelector('a').focus(); currentDropdown = dropdown; document.body.addEventListener('click', handleClickOutside); document.body.addEventListener('keyup', handleEsc); Array.from(dropdown.querySelectorAll('a')) .forEach(link => link.addEventListener('blur', handleFocusOutside)); } }); }); // handle clicking outside a focused dropdown function handleClickOutside(ev) { if (currentDropdown.contains(ev.target)) return; closeDropdown(false); } function handleEsc(ev) { if (ev.code === 'Escape') closeDropdown(true); } // handle tabbing away from a focused dropdown function handleFocusOutside(ev) { const links = Array.from(currentDropdown.querySelectorAll('a')); // since this is on the blur event of each dropdown link, we need to give // the browser time to actually focus the next element setTimeout(function () { if (links.indexOf(document.activeElement) > -1) return; closeDropdown(true); }, 0); } function closeDropdown(focus) { currentDropdown.classList.remove(activeClass); document.body.removeEventListener('click', handleClickOutside); document.body.removeEventListener('keyup', handleEsc); Array.from(currentDropdown.querySelectorAll('a')) .forEach(link => link.removeEventListener('blur', handleFocusOutside)); if (focus) currentDropdown.parentNode.firstElementChild.focus(); currentDropdown = null; } }; // automatically create slideshow tab indicators exports.createHomeSlideshowTabs = function createHomeSlideshowTabs() { var tab = document.createElement('button'); tab.className = 'home-feature__tab tabs__tab'; tab.setAttribute('type', 'button'); _.forEach(document.getElementsByClassName('home-feature'), function (feature) { var nav = feature.querySelector('.home-feature__nav'); if (!nav) { nav = document.createElement('div'); nav.className = 'home-feature__nav'; feature.appendChild(nav); } _.forEach(feature.querySelectorAll('.tabs__pane'), function (pane) { nav.appendChild(tab.cloneNode(true)); }); }); }; // initialize ukiyo for parallax effects exports.initializeParallax = function initializeParallax() { if (typeof Ukiyo === 'function') { _.forEach(document.querySelectorAll('.use-parallax'), function (el) { new Ukiyo(el, { scale: 1.25, speed: 1.5, willChange: true, wrapperClass: 'use-parallax__wrapper', }); }); } }; // combine adjacent tabs modules when placed in Sitefinity exports.combineTabs = function combineTabs() { // combine under the first parent var containers = toArray(document.querySelectorAll('.sf_cols.tabs')), currentContainer, currentType, children; if (containers.length > 0 && !document.body.classList.contains('sfPageEditor')) { for (var i = 0; i < containers.length; i++) { currentContainer = containers[i]; currentType = currentContainer.className; while (currentContainer.nextElementSibling && currentContainer.nextElementSibling.className === currentType) { children = toArray(currentContainer.nextElementSibling.querySelectorAll('.tabs__tab, .tabs__pane')); while (children.length) { currentContainer.appendChild(children.shift()); } currentContainer.parentNode.removeChild(currentContainer.nextElementSibling); } } } // reorder and count children _.forEach(document.querySelectorAll('.sf_cols.tabs'), function (container) { _.forEach(container.querySelectorAll('.tabs__tab'), function (tab) { container.appendChild(tab); }); _.forEach(container.querySelectorAll('.tabs__pane'), function (pane) { container.appendChild(pane); }); }); }; // add body waypoint for sticky header exports.addHeaderWaypoint = function addHeaderWaypoint() { document.body.setAttribute('data-waypoints', '1px: is-scrolled'); }; return exports; }()); /* =initialize modules * =================== */ var init = function () { // functions that must run before large modules // e.g. functions that output toggles that must then be initialized misc.combineTabs(); misc.addHeaderWaypoint(); misc.addNavDrilldownButtons(); misc.createHomeSlideshowTabs(); // large modules toggles.init(); tabs.init(); sharedHeights.init(); waypoints.init(); truncators.init(); horizontalScrollers.init(); sharing.init(); // misc modules misc.addMobileMenuToggle(); misc.focusInputLabels(); misc.dropdownKeyboardNav(); misc.addInputUtilityClasses(); misc.initializeParallax(); document.documentElement.classList.remove('no-js'); document.documentElement.classList.add('js'); }; /* =public * ======= */ return { xhr: xhr, toggles: toggles, tabs: tabs, sharedHeights: sharedHeights, waypoints: waypoints, sharing: sharing, horizontalScrollers: horizontalScrollers, init: init, }; }(window, document)); RDJS.init(); </script><script type="text/javascript" src="/Scripts/Annual2023-scripts/ukiyo.min.js"></script><script type="text/javascript">document.addEventListener('DOMContentLoaded', function () { var docExts = [".pdf", ".doc", ".xls", ".ppt", ".txt", "/docs/"]; docExts.forEach(function (index) { document.querySelectorAll('a[href*="' + index + '"]').forEach( function (e) { e.onclick = function () { // old ga('send', 'event', 'Document', 'Download', this.href); // new dataLayer.push({ 'event': 'gaEvent', 'eventCategory': 'Document', 'eventAction': 'Download', 'eventLabel': this.href }); 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