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CVLs - Twist Bioscience
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href="/de/products/ngs/library-preparation/mechanical-fragmentation-kit" class=""> Kit zur mechanischen Fragmentierung </a> </li> </ul> </div> </li> <li class="menu-item-as-title menu-item" data-column-position=1 data-column-v-weight=1> <a href="/de/productchild/Long-Read-Sequencing" class="menu-item-as-title menu-item level-2-category-item"> Long-Read-Panels </a> </li> <li class="menu-item menu-item--expanded level-2-category-section" data-column-position=1 data-column-v-weight=1> <div class="level-2-category-section "> <a href="https://www.twistbioscience.com/de/products/ngs/rna-seq-solutions" class="menu-item menu-item--expanded level-2-category-section level-2-category-item"> RNA-Sequenzierung > </a> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="https://www.twistbioscience.com/de/products/ngs/rna-sequencing-solutions?tab=rna-library-prep" class=""> RNA Library Prep </a> </li> <li class="menu-item"> <a href="https://www.twistbioscience.com/de/products/ngs/rna-sequencing-solutions?tab=rna-exome" class=""> RNA-Exom </a> </li> <li class="menu-item"> <a href="https://www.twistbioscience.com/de/products/ngs/rna-sequencing-solutions?tab=rna-fusion" class=""> RNA-Fusion </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded level-2-category-section" data-column-position=3 data-column-v-weight=1> <div class="level-2-category-section "> <span class="menu-item menu-item--expanded level-2-category-section level-2-category-item"> Reagenzien und Kits </span> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="/de/products/ngs/reagent-kits/fast-hybridization-and-wash-kit" class=""> Fast Hybridization and Wash Kit </a> </li> <li class="menu-item"> <a href="/de/products/ngs/reagent-kits/standard-hybridization-and-wash-kit" class=""> Standard Hybridization Reagent Kit </a> </li> <li class="menu-item"> <a href="/de/products/ngs/reagent-kits/universal-blockers" class=""> Universal Blockers </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded level-2-category-section" data-column-position=3 data-column-v-weight=1> <div class="level-2-category-section "> <span class="menu-item menu-item--expanded level-2-category-section level-2-category-item"> Kontrollen und Standards </span> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="/de/products/ngs/twist-cfdna-pan-cancer-reference-standards" class=""> cfDNA Pan-Cancer Reference Standards v2<span class="menu-link-new">Neu</span> </a> </li> <li class="menu-item"> <a href="/de/products/ngs/synthetic-viral-controls?tab=monkeypox-controls" class=""> Mpox-Virus-Kontrollen </a> </li> <li class="menu-item"> <a href="/de/products/ngs/synthetic-viral-controls?tab=sars-cov-2-controls" class=""> SARS-COV-2-Kontrollen </a> </li> <li class="menu-item"> <a href="/de/products/ngs/synthetic-viral-controls?tab=respiratory-virus-controls" class=""> Atemwegsvirus-Kontrollen </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded level-2-category-section" data-column-position=1 data-column-v-weight=1> <div class="level-2-category-section "> <span class="menu-item menu-item--expanded level-2-category-section level-2-category-item"> Festpanels </span> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="/de/products/ngs/fixed-panels/exome2" class=""> Exome 2.0 </a> </li> <li class="menu-item"> <a href="/de/products/ngs/fixed-panels/human-comprehensive-exome" class=""> Human Comprehensive Exome </a> </li> <li class="menu-item"> <a href="/de/products/ngs/fixed-panels/human-core-exome" class=""> Human Core Exome </a> </li> <li class="menu-item"> <a href="https://www.twistbioscience.com/de/products/ngs/fixed-panels/human-methylome-panel" class=""> Human Methylome Panel </a> </li> <li class="menu-item"> <a href="/de/products/ngs/fixed-panels/human-refseq-panel" class=""> Human RefSeq Panel </a> </li> <li class="menu-item"> <a href="/de/products/ngs/fixed-panels/mitochondrial-panel" class=""> Mitochondrial Panel </a> </li> <li class="menu-item"> <a href="/de/products/ngs/fixed-panels/mouse-exome-panel" class=""> Mouse Exome Panel </a> </li> <li class="menu-item"> <a href="/de/products/ngs/fixed-panels/respiratory-virus-research-panel" class=""> Twist Respiratory Virus Research Panel </a> </li> <li class="menu-item"> <a href="/de/products/ngs/fixed-panels/comprehensive-viral-research-panel" class=""> Comprehensive Viral Research Panel </a> </li> </ul> </div> </li> </ul> </div> <a href="https://www.twistbioscience.com/de/products/precision-dx" class="promo-box"> <div class="promo-box__image"> <img src="https://www.twistbioscience.com/sites/default/files/2024-03/Twist%20Promo%20Banner%20-%20IVDR%20Clinical%20Icon-213x136-V1%20%281%29.jpg" alt="Twist-Workflow zur Gesamtexom-Libraryvorbereitung. Mehr erfahren >"> </div> <p>Twist-Workflow zur Gesamtexom-Libraryvorbereitung. Mehr erfahren ></p> </a> </div> <div class="primary-menu__dropdown-content" data-tab-drawer-4 data-index="data-tab-drawer-4"> <div class="primary-menu__dropdown-columns"> <h2> <a href="/de/products/libraries"> <img src="https://www.twistbioscience.com/sites/default/files/2021-05/icon-libraries.png" alt="Variant Libraries"> Variant Libraries </a> </h2> <ul class="sub-nav-columns total-columns-2" data-sub-nav-columns="2"> <li data-sub-nav-column="1"></li> <li data-sub-nav-column="2"></li> </ul> <a href="/de/get-quote" class="main-action">Jetzt bestellen</a> <ul class="menu menu-level-2"> <li class="menu-item" data-column-position=1 data-column-v-weight=1> <a href="/de/tcr-libraries" class="menu-item level-2-category-item"> TCR-Libraries <span class="menu-link-new">Neu</span> </a> </li> <li class="menu-item" data-column-position=1 data-column-v-weight=1> <a href="/de/products/libraries/combinatorial-variant-library" class="menu-item level-2-category-item"> CVL </a> </li> <li 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gewährleisten."> </div> <p>Sehen Sie, wie Twist Variant Libraries erstellt, die eine optimale Anwendung gewährleisten.</p> </a> </div> <div class="primary-menu__dropdown-content" data-tab-drawer-5 data-index="data-tab-drawer-5"> <div class="primary-menu__dropdown-columns"> <h2> <a href="/de/products/ngs/synthetic-viral-controls"> <img src="https://www.twistbioscience.com/sites/default/files/2022-01/Synthetic%20Controls-1_0.png" alt="Synthetische Kontrollen"> Synthetische Kontrollen </a> </h2> <ul class="sub-nav-columns total-columns-2" data-sub-nav-columns="2"> <li data-sub-nav-column="1"></li> <li data-sub-nav-column="2"></li> </ul> <a href="https://ecommerce.twistdna.com/app/sars-cov-2" class="main-action">Jetzt bestellen</a> <ul class="menu menu-level-2"> <li class="menu-item menu-item--expanded level-2-category-section" data-column-position=1 data-column-v-weight=1> <div class="level-2-category-section "> <span class="menu-item menu-item--expanded level-2-category-section level-2-category-item"> Flüssigbiopsie </span> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="/de/products/ngs/twist-cfdna-pan-cancer-reference-standards" class=""> cfDNA Pan-Cancer Reference Standards v2<span class="menu-link-new">Neu</span> </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded level-2-category-section" data-column-position=1 data-column-v-weight=1> <div class="level-2-category-section "> <a href="/de/products/ngs/synthetic-viral-controls" class="menu-item menu-item--expanded level-2-category-section level-2-category-item"> Infektionskrankheit </a> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="/de/products/ngs/synthetic-viral-controls?tab=respiratory-virus-controls" class=""> Atemwegsvirus-Kontrollen </a> </li> <li class="menu-item"> <a href="/de/products/ngs/synthetic-viral-controls?tab=sars-cov-2-controls" class=""> SARS-COV-2-Kontrollen </a> </li> <li class="menu-item"> <a href="/de/products/ngs/synthetic-viral-controls?tab=monkeypox-controls" class=""> Mpox-Virus-Kontrollen </a> </li> </ul> </div> </li> </ul> </div> <a href="/de/products/ngs/twist-cfdna-pan-cancer-reference-standards" class="promo-box"> <div class="promo-box__image"> <img src="https://www.twistbioscience.com/sites/default/files/2022-01/synthetic%20controls%20dev_0.png" alt="Sehen Sie sich unsere neuen synthetischen Kontrollen für die Entwicklung von Flüssigbiopsie-Tests an"> </div> <p>Sehen Sie sich unsere neuen synthetischen Kontrollen für die Entwicklung von Flüssigbiopsie-Tests an</p> </a> </div> <div class="primary-menu__dropdown-content" data-tab-drawer-6 data-index="data-tab-drawer-6"> <div class="primary-menu__dropdown-columns"> <h2> <a href="/de/twist-biopharma-solutions"> <img src="https://www.twistbioscience.com/sites/default/files/2021-05/icon-antibodies.png" alt="Antikörperidentifizierung"> Antikörperidentifizierung </a> </h2> <ul class="sub-nav-columns total-columns-2" data-sub-nav-columns="2"> <li data-sub-nav-column="1"></li> <li data-sub-nav-column="2"></li> </ul> <a href="https://ecommerce.twistdna.com/app/igg" class="main-action">Jetzt bestellen</a> <ul class="menu menu-level-2"> <li class="menu-item-as-title menu-item menu-item--expanded level-2-category-section" data-column-position=1 data-column-v-weight=1> <div class="level-2-category-section "> <a href="/de/antibody-discovery/critical-reagents" class="menu-item-as-title menu-item menu-item--expanded level-2-category-section level-2-category-item"> Wichtige Reagenzien und Tool-Antikörper </a> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="https://www.twistbioscience.com/de/product/antibody-discovery/reagents-and-tools/anti-id" class=""> Anti-ID Antibody Discovery </a> </li> <li class="menu-item"> <a href="/de/products/antibody-discovery/in-vivo/abveris-antigen-production-design" class=""> Antigen Generation </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded level-2-category-section" data-column-position=1 data-column-v-weight=1> <div class="level-2-category-section "> <a href="/de/antibody-discovery/in-vitro-antibody-discovery" class="menu-item menu-item--expanded level-2-category-section level-2-category-item"> In-vitro > </a> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="/de/products/antibody-discovery/custom-library-design-and-generation" class=""> Benutzerdefinierte Library erzeugen </a> </li> <li class="menu-item"> <a href="/de/products/antibody-discovery/library-of-libraries" class=""> Library of Libraries: </a> </li> <li class="menu-item"> <a href="/de/products/antibody-discovery/phage-display-antibody-discovery" class=""> Phage Display </a> </li> </ul> </div> </li> <li class="menu-item-as-title menu-item menu-item--expanded level-2-category-section" data-column-position=2 data-column-v-weight=1> <div class="level-2-category-section "> <a href="/de/antibody-discovery/twist-antibody-optimization" class="menu-item-as-title menu-item menu-item--expanded level-2-category-section level-2-category-item"> Optimierung und Entwicklung von Antikörpern </a> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="/de/product/antibody-discovery/engineering-and-optimization/TAO" class=""> Twist Antibody Optimization (TAO) </a> </li> <li class="menu-item"> <a href="/de/product/antibody-discovery/engineering-and-optimization/affinity-maturation" class=""> AI/ML Affinity Maturation </a> </li> <li class="menu-item"> <a href="/de/product/antibody-discovery/engineering-and-optimization/humanization" class=""> In-silico-Humanisierung </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded level-2-category-section" data-column-position=2 data-column-v-weight=1> <div class="level-2-category-section "> <a href="/de/antibody-discovery/in-vivo-antibody-discovery" class="menu-item menu-item--expanded level-2-category-section level-2-category-item"> In-vivo > </a> <ul class="menu 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href="/de/products/antibody-discovery/high-throughput-antibody-production?tab=cho-express-antibodies" class=""> CHO Express-Antikörper </a> </li> <li class="menu-item"> <a href="/de/products/antibody-discovery/high-throughput-antibody-production?tab=hek239-express-antibodies" class=""> HEK293 Express-Antikörper </a> </li> </ul> </div> </li> <li class="menu-item-as-title menu-item menu-item--expanded level-2-category-section" data-column-position=1 data-column-v-weight=1> <div class="level-2-category-section "> <a href="https://www.twistbioscience.com/de/product/antibody-discovery/characterization" class="menu-item-as-title menu-item menu-item--expanded level-2-category-section level-2-category-item"> Antikörpercharakterisierung > </a> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="https://www.twistbioscience.com/de/product/antibody-discovery/characterization/SPR" class=""> Biophysical Characterization by SPR </a> </li> <li class="menu-item"> <a href="/de/product/antibody-discovery/characterization/developability" class=""> Bewertung der Entwicklungsfähigkeit </a> </li> <li class="menu-item"> <a href="/de/product/antibody-discovery/characterization/functional-assays" class=""> Functional Assays </a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded level-2-category-section" data-column-position=2 data-column-v-weight=1> <div class="level-2-category-section "> <a href="/de/antibody-discovery/asset-licensing" class="menu-item menu-item--expanded level-2-category-section level-2-category-item"> Asset-Lizenzierung > </a> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="/de/products/biopharma/antibody-partnerships-and-collaborations" class=""> Partnerschaften und Kooperationen </a> </li> </ul> </div> </li> </ul> </div> <a href="/de/resources/product-sheet/target-molecule" class="promo-box"> <div class="promo-box__image"> <img src="https://www.twistbioscience.com/sites/default/files/2021-05/biopharma-global-213x136%402x_0.png" alt="Lesen Sie unser neues E-Book zur Antikörperidentifizierung und <br>-entwicklung."> </div> <p>Lesen Sie unser neues E-Book zur Antikörperidentifizierung und <br>-entwicklung.</p> </a> </div> </div> </div> </div> </li> <li class="menu-item menu-item--expanded js-primary-menu-wide-mode"> <span title="" id="" name="" rel="" style="" target="" accesskey="">Anwendungen</span> <div data-primary-nav-subnav-container class="wide-menu-sub-navigation"> <div class="primary-nav__drawer-side-bar"> <div class="menu-dropdown menu-dropdown-0"> <ul class="menu menu-level-1" data-tabs > <li class="menu-item menu-item--expanded" data-tab="data-tab-drawer-1" > <a href="https://www.twistbioscience.com/de/good-fight-june-6"> <span>Krebsforschung</span> </a> </li> <li class="menu-item menu-item--large-icon" > <a href="/de/products/storage"> <span>DNA-Datenspeicherung</span> </a> </li> <li 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menu-item--expanded level-2-category-section" data-column-position=1 data-column-v-weight=1> <div class="level-2-category-section "> <span class="menu-item menu-item--expanded level-2-category-section level-2-category-item"> Flüssigbiopsie </span> <ul class="menu menu-level-3"> <li class="menu-item"> <a href="https://www.twistbioscience.com/de/products/ngs/library-preparation/cfDNA-library-prep-kit" class=""> cfDNA Library Preparation Kit<span class="menu-link-new">Neu</span> </a> </li> <li class="menu-item"> <a href="https://www.twistbioscience.com/de/products/ngs/Twist-cfDNA-Pan-Cancer-Reference-Standard-v2" class=""> cfDNA Pan-Cancer Reference Standards v2<span class="menu-link-new">Neu</span> </a> </li> <li class="menu-item"> <a href="/de/pages/personalized-sequencing" class=""> Minimale Resterkrankung<span class="menu-link-new">Neu</span> </a> </li> </ul> </div> </li> </ul> </div> <a href="/de/pages/personalized-sequencing" class="promo-box"> <div class="promo-box__image"> <img 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menu-level-2"> <li class="mobile-menu-item"> <a href="/de/ngs-prolab-certificate-program1"> NGS ProLab </a> </li> <li class="mobile-menu-item"> <a href="/de/productchild/channel-partners-and-distributors-page?tab=overview"> Vertriebspartner und Distributoren </a> </li> </ul> </div> </nav> </section> </aside> <div id="main-wrapper" class="layout-main-wrapper clearfix"> <div id="main"> <div class="row-offcanvas row-offcanvas-left clearfix"> <main class="main-content col" id="content" role="main"> <section class="section"> <a id="main-content" tabindex="-1"></a> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-twist-barrio-content" class="block block-system block-system-main-block"> <div class="content"> <article data-history-node-id="6761" about="/products/libraries/combinatorial-variant-libraries" class="node node--type-product-child node--view-mode-full product-style-orange product-combinatorial-variant-libraries" data-product="combinatorial-variant-libraries"> <div class="node__content"> <div class="field field--name-field-page-banner field--type-entity-reference-revisions field--label-hidden field__item"> <style> @media (min-width: 768px) { .paragraph--type--banner { background-image: url(https://www.twistbioscience.com/sites/default/files/2020-12/bg-libraries-child%402x_0.png); background-size: cover; } } @media (max-width: 767px) { .paragraph--type--banner { background-image: url(https://www.twistbioscience.com/sites/default/files/2020-12/bg-libraries-child%402x_0.png); background-size: cover; } } </style> <div class="banner paragraph paragraph--type--banner paragraph--view-mode--default"> <div class="banner__content"> <div class="banner-preview-image-wrapper tablet-preview-image"> </div> <div class="container"> <div class="row"> <div class="banner__title col-md-7"> <div class="title"> <h1>CVL</h1> </div> </div> <div class="header-right-container-wrapper col-md-5"> </div> </div> </div> </div> </div> </div> <div class="system-picker-for-tabs d-md-none" > <div class="title-picker"> <span class="chosen-tab-title"></span> <select> <option value="1">ÜBERSICHT</option> <option value="2">DATEN</option> <option value="3">BESTELLUNG</option> <option value="4">RESSOURCEN</option> </select> </div> </div> <div class="system-sticky-tabs"> <div class="sticky-wrapper"> <div class="sticky-wrapper-tabs"> <span class="tab-item" data-id="1" data-twist-element="tab" data-twist-location="product-tabs-sticky" data-twist-type="tab">ÜBERSICHT</span> <span class="tab-item" data-id="2" data-twist-element="tab" data-twist-location="product-tabs-sticky" data-twist-type="tab">DATEN</span> <span class="tab-item" data-id="3" data-twist-element="tab" data-twist-location="product-tabs-sticky" data-twist-type="tab">BESTELLUNG</span> <span class="tab-item" data-id="4" data-twist-element="tab" data-twist-location="product-tabs-sticky" data-twist-type="tab">RESSOURCEN</span> </div> </div> </div> <div class="field field--name-field-pc-tabs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item select-picker-0 active-picker" data-id="0"> <div class="no-custom-show-more paragraph paragraph--type--section-tabs paragraph--view-mode--default array" data-style="array"> <div class="field field--name-field-cp-title field--type-string field--label-hidden field__item" id="overview">Übersicht</div> <div class="field field--name-field-cp-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="desktop-layer"> <div class="container"> <div class="virtual-wrapper row"> <div class="virtual-region-left col-md-7"> <div class="clearfix component-paragraph paragraph paragraph--type--component-text paragraph--view-mode--default"> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><h3><span><span><span><span><span><span>Variant Library-Präzisionstechnologie ermöglicht zielgerichtete Analysen</span></span></span></span></span></span></h3> <p><span><span><span><span><span><span>Die massiv parallele siliziumbasierte DNA-Syntheseplattform von Twist erzeugt äußerst einheitliche und genaue Oligonukleotide, wobei 90 % der Oligonukleotide innerhalb des <2,5-Fachen des Mittelwerts liegen, zusammen mit einer branchenführenden niedrigen Fehlerrate von 1:2.000 nt. </span></span></span></span></span></span></p> <p><span><span><span><span><span><span>In Kombination mit unserer umfassenden Erfahrung in der Molekularbiologie ermöglicht die Oligonukleotid-Syntheseplattform von Twist die Herstellung sehr unterschiedlicher Genmutanten-Libraries mit ausgezeichneter Variantenrepräsentation und hochspezifischer benutzerdefinierter Zusammensetzung, und zwar ohne unerwünschte Verzerrungen oder Motive. Die Twist-Library-Technologie ermöglicht eine umfassende Interrogation des Varianten-Sequenzabschnitts.</span></span></span></span></span></span></p></div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div class="field field--name-field-cp-section-label field--type-string field--label-hidden field__item">HAUPTVORTEILE</div> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2020-12/target1-orange_0.svg" alt="Hochdiversitätspräzision" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Hochdiversitätspräzision</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Einfache Integration verschiedener Variantendomänen in eines oder mehrere Scaffolds</div> <div class="field__item">Präzise Kontrolle der Codonverwendung (alle 64 Codone), Verteilung der Aminosäuren und Längenvariation</div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2020-12/icon-benefit-confidence-orange_0.svg" alt="Verifizierte Qualität" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Verifizierte Qualität</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Rigorose Qualitätskontrolle, einschließlich NGS-Verifizierung von modifizierten Bereichen</div> <div class="field__item">Variantenverhältnis der Sequenzen dokumentiert</div> <div class="field__item">Gleichmäßige Verteilung der benutzerdefinierten Varianten</div> <div class="field__item">Keine vorzeitigen Stoppcodons oder unerwünschten Codons</div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2020-12/icon-benefit-flexibility-orange_0.svg" alt="Flexibilität" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Flexibilität</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Design aller Sequenzen, einzelne oder multiple Domänen und Kombinationen – einzelne, paarweise oder dreifache Varianten</div> <div class="field__item">Modulares Synthesesystem befähigt die Iteration von zukünftigen Libraries</div> <div class="field__item">Höhere Flexibilität als TRIM und der Degenerationsansatz </div> </div> </div> </div> </div> <div class="virtual-region-right col-md-4"> <div class="virtual-region-sticky-col"> <div class="orange clearfix component-paragraph paragraph paragraph--type--component-callout paragraph--view-mode--default"> <div class="field field--name-field-cp-callout-title field--type-string field--label-hidden field__item">Variant Library-Präzisionstechnologie ermöglicht zielgerichtete Analysen</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Erfahren Sie mehr über die Fähigkeit von Twist, komplexe Libraries mit hoher Diversität in begrenzten Regionen (z. B. CDRs) zu konstruieren, und stellen technologische Fortschritte vor, die den Aufbau synthetischer DNA-Libraries mit über die Länge der Konstrukte verstreuter Diversität ermöglichen.</p> <p><a class="green-link" href="/de/resources/webinar/precision-variant-library-technology-allows-focused-screening">Webinar ansehen</a></p></div> </div> <div class="orange clearfix component-paragraph paragraph paragraph--type--component-callout paragraph--view-mode--default"> <div class="field field--name-field-cp-callout-title field--type-string field--label-hidden field__item">Wussten Sie, dass die Ionenladung die Antikörper-Target-Bindung beeinflussen kann?</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Erfahren Sie, wie Twist einem führenden Pharmaunternehmen dabei geholfen hat, Schlüsselrückstände, die sowohl an der Target-Erkennung als auch an der Antikörperladung beteiligt sind, durch die Synthese kombinatorischer <a href="https://www.twistbioscience.com/de/resources/application-note/optimizing-candidate-therapeutic-antibody-optimize-pharmacokinetics">Varianten-Libraries</a> <a href="https://www.twistbioscience.com/de/resources/application-note/optimizing-candidate-therapeutic-antibody-optimize-pharmacokinetics">genau zu interrogieren</a>.</p> <p><a href="https://www.twistbioscience.com/de/did-you-know#1857">VIDEO ANSEHEN</a></p> <p> </p> </div> </div> <div class="orange clearfix component-paragraph paragraph paragraph--type--component-callout paragraph--view-mode--default"> <div class="field field--name-field-cp-callout-title field--type-string field--label-hidden field__item">Einführung in das neue Library-Design-Tool von Twist </div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p><span><span><span><span><span><span>Optimiertes Library-Design im Handumdrehen</span></span></span></span></span></span></p> <p><br> <a href="https://www.twistbioscience.com/de/products/libraries/combinatorial-variant-libraries?tab=ordering"><span><span><span><span><span><span><span><span>Mehr erfahren</span></span></span></span></span></span></span></span></a><span><span><span><span><span><span> </span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><img alt="Banner" class="twist-lightbox" data-entity-type="file" data-entity-uuid="1b416cdd-136b-4e07-94cd-99d85b865bf5" id src="https://www.twistbioscience.com/sites/default/files/inline-images/ALTVlibspromobanner628x288%402x_0.png" title width="1257" height="577" data-mfp-src="/sites/default/files/inline-images/ALTVlibspromobanner628x288%402x_0.png" loading="lazy"></span></span></span></span></span></span></span></span></p></div> </div> </div> </div> <div class="clearfix"></div> </div> </div> </div> <div class="mobile-layer"> <div class="clearfix component-paragraph paragraph paragraph--type--component-text paragraph--view-mode--default"> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><h3><span><span><span><span><span><span>Variant Library-Präzisionstechnologie ermöglicht zielgerichtete Analysen</span></span></span></span></span></span></h3> <p><span><span><span><span><span><span>Die massiv parallele siliziumbasierte DNA-Syntheseplattform von Twist erzeugt äußerst einheitliche und genaue Oligonukleotide, wobei 90 % der Oligonukleotide innerhalb des <2,5-Fachen des Mittelwerts liegen, zusammen mit einer branchenführenden niedrigen Fehlerrate von 1:2.000 nt. </span></span></span></span></span></span></p> <p><span><span><span><span><span><span>In Kombination mit unserer umfassenden Erfahrung in der Molekularbiologie ermöglicht die Oligonukleotid-Syntheseplattform von Twist die Herstellung sehr unterschiedlicher Genmutanten-Libraries mit ausgezeichneter Variantenrepräsentation und hochspezifischer benutzerdefinierter Zusammensetzung, und zwar ohne unerwünschte Verzerrungen oder Motive. Die Twist-Library-Technologie ermöglicht eine umfassende Interrogation des Varianten-Sequenzabschnitts.</span></span></span></span></span></span></p></div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div class="field field--name-field-cp-section-label field--type-string field--label-hidden field__item">HAUPTVORTEILE</div> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2020-12/target1-orange_0.svg" alt="Hochdiversitätspräzision" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Hochdiversitätspräzision</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Einfache Integration verschiedener Variantendomänen in eines oder mehrere Scaffolds</div> <div class="field__item">Präzise Kontrolle der Codonverwendung (alle 64 Codone), Verteilung der Aminosäuren und Längenvariation</div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2020-12/icon-benefit-confidence-orange_0.svg" alt="Verifizierte Qualität" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Verifizierte Qualität</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Rigorose Qualitätskontrolle, einschließlich NGS-Verifizierung von modifizierten Bereichen</div> <div class="field__item">Variantenverhältnis der Sequenzen dokumentiert</div> <div class="field__item">Gleichmäßige Verteilung der benutzerdefinierten Varianten</div> <div class="field__item">Keine vorzeitigen Stoppcodons oder unerwünschten Codons</div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2020-12/icon-benefit-flexibility-orange_0.svg" alt="Flexibilität" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Flexibilität</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Design aller Sequenzen, einzelne oder multiple Domänen und Kombinationen – einzelne, paarweise oder dreifache Varianten</div> <div class="field__item">Modulares Synthesesystem befähigt die Iteration von zukünftigen Libraries</div> <div class="field__item">Höhere Flexibilität als TRIM und der Degenerationsansatz </div> </div> </div> </div> <div class="orange clearfix component-paragraph paragraph paragraph--type--component-callout paragraph--view-mode--default"> <div class="field field--name-field-cp-callout-title field--type-string field--label-hidden field__item">Variant Library-Präzisionstechnologie ermöglicht zielgerichtete Analysen</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Erfahren Sie mehr über die Fähigkeit von Twist, komplexe Libraries mit hoher Diversität in begrenzten Regionen (z. B. CDRs) zu konstruieren, und stellen technologische Fortschritte vor, die den Aufbau synthetischer DNA-Libraries mit über die Länge der Konstrukte verstreuter Diversität ermöglichen.</p> <p><a class="green-link" href="/de/resources/webinar/precision-variant-library-technology-allows-focused-screening">Webinar ansehen</a></p></div> </div> <div class="orange clearfix component-paragraph paragraph paragraph--type--component-callout paragraph--view-mode--default"> <div class="field field--name-field-cp-callout-title field--type-string field--label-hidden field__item">Wussten Sie, dass die Ionenladung die Antikörper-Target-Bindung beeinflussen kann?</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Erfahren Sie, wie Twist einem führenden Pharmaunternehmen dabei geholfen hat, Schlüsselrückstände, die sowohl an der Target-Erkennung als auch an der Antikörperladung beteiligt sind, durch die Synthese kombinatorischer <a href="https://www.twistbioscience.com/de/resources/application-note/optimizing-candidate-therapeutic-antibody-optimize-pharmacokinetics">Varianten-Libraries</a> <a href="https://www.twistbioscience.com/de/resources/application-note/optimizing-candidate-therapeutic-antibody-optimize-pharmacokinetics">genau zu interrogieren</a>.</p> <p><a href="https://www.twistbioscience.com/de/did-you-know#1857">VIDEO ANSEHEN</a></p> <p> </p> </div> </div> <div class="orange clearfix component-paragraph paragraph paragraph--type--component-callout paragraph--view-mode--default"> <div class="field field--name-field-cp-callout-title field--type-string field--label-hidden field__item">Einführung in das neue Library-Design-Tool von Twist </div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p><span><span><span><span><span><span>Optimiertes Library-Design im Handumdrehen</span></span></span></span></span></span></p> <p><br> <a href="https://www.twistbioscience.com/de/products/libraries/combinatorial-variant-libraries?tab=ordering"><span><span><span><span><span><span><span><span>Mehr erfahren</span></span></span></span></span></span></span></span></a><span><span><span><span><span><span> </span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><img alt="Banner" class="twist-lightbox" data-entity-type="file" data-entity-uuid="1b416cdd-136b-4e07-94cd-99d85b865bf5" id src="https://www.twistbioscience.com/sites/default/files/inline-images/ALTVlibspromobanner628x288%402x_0.png" title width="1257" height="577" data-mfp-src="/sites/default/files/inline-images/ALTVlibspromobanner628x288%402x_0.png" loading="lazy"></span></span></span></span></span></span></span></span></p></div> </div> </div> </div> </div> </div> <div class="field__item select-picker-1" data-id="1"> <div class="no-custom-show-more paragraph paragraph--type--section-tabs paragraph--view-mode--default array" data-style="array"> <div class="field field--name-field-cp-title field--type-string field--label-hidden field__item" id="data">DATEN</div> <div class="field field--name-field-cp-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="desktop-layer"> <div class="container"> <div class="virtual-wrapper row"> <div class="clearfix"></div> <div class="virtual-region-bottom"> <div class="clearfix component-paragraph paragraph paragraph--type--component-description-figure paragraph--view-mode--default"> <div class="clearfix"> <div class="group-left"> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Hochwertige Daten</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Die siliziumbasierte DNA-Syntheseplattform und Library-Technologie von Twist Bioscience bietet Wissenschaftlern qualitativ hochwertige Libraries, die in kürzerer Zeit zuverlässige Daten liefern. Im Vergleich zu zwei anderen konkurrierenden Technologien (Abbildung 1) zeigte die Twist-Library weniger als 1 % Abweichung von der vorgesehenen Aminosäurefrequenz. Zusätzlich zum präzisen Abgleich der vorgesehenen Aminosäureverhältnisse integriert die In-silico-DNA-Syntheseplattform von Twist nahtlos erwünschte Bindungsmotive und Längenvariationen in Multi-Domain-Libraries, was Wissenschaftlern die Möglichkeit gibt, in präziser Weise Variant Libraries zu entwerfen und anzupassen, die eine umfassende Analyse des Variantenraums ermöglichen.</p> <p>Außerdem werden mit Twist-Libraries die für NNK- und TRIM-Libraries typischen Probleme und Schwierigkeiten vermieden. Jede Variante wird Base für Base gedruckt und vor der Synthese überprüft, um Stoppcodons, Haftungsmotive, unerwünschte Mutationen und unerwünschte Verzerrungen bereits zu Beginn des Prozesses zu eliminieren. Dadurch wird die Library mit den gewünschten funktionalen Varianten angereichert und der Aufwand für das Screening verringert.</p> <p>Unsere branchenführenden, sofort einsatzbereiten, hochdiversen und präzise konzipierten Libraries bieten Wissenschaftlern mehr Möglichkeiten, ihre Forschungsziele zu erreichen.</p> </div> </div> <div class="group-right"> <div class="field field--name-field-cp-df-image field--type-image field--label-hidden field__item"> <img class="twist-lightbox" data-mfp-src="/sites/default/files/2021-10/technology-comparison-nnk-vs-trimer-vs-twist_2.svg" src="/de/sites/default/files/2021-10/technology-comparison-nnk-vs-trimer-vs-twist_2.svg" width="700" height="400" alt="Vergleich der Twist-Technologie NNK im Vergleich zu Trimer im Vergleich zu Twist" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-description-figure paragraph--view-mode--default"> <div class="clearfix"> <div class="group-left"> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Überlegene Libraries</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Twist nutzt die eigene Erfahrung mit Molekularbiologie zur präzisen Konstruktion der Variant Libraries. Unser Ansatz der Einzelbasis-Kontrolle ermöglicht es uns, hochdiverse Libraries ohne Motive zu liefern, die Ihre Screening-Prozesse verwirren könnten. Wir liefern vollständig angepasste Libraries von einmaliger Qualität, in denen die gewünschten Varianten zu von den Nutzern definierten Verhältnissen vorhanden sind. Hier sehen Sie ein CVL-Beispiel, welches diese Qualität repräsentiert. Es wurden Varianten in sieben aufeinanderfolgenden Aminosäurepositionen erzeugt, und alle haben die erwarteten Varianten an den gezeigten Positionen, wobei fast alle das gewünschte Verhältnis aufweisen:</p> <p>An den Positionen 1 und 6 sollte die Wildtyp-Aminosäure bei 40 % (Position 1) und 30 % (Position 7) liegen. Für die übrigen 18 Aminosäuren wurde ein Anteil von 3,3 % gefordert.</p> <p>An den Positionen 3 bis 5 sollten die Aminosäurenreste bei 5,3 % liegen, was dann auch beobachtet wurde.</p> </div> </div> <div class="group-right"> <div class="field field--name-field-cp-df-image field--type-image field--label-hidden field__item"> <img class="twist-lightbox" data-mfp-src="/sites/default/files/2020-12/VariantLibraries-CVL-Distribution1.svg" src="/de/sites/default/files/2020-12/VariantLibraries-CVL-Distribution1.svg" width="700" height="430" alt="Variant Library CVL-Verteilung " loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-description-figure paragraph--view-mode--default"> <div class="clearfix"> <div class="group-left"> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Benutzerdefinierte CDR-Libraries</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Unsere Precise Variant Libraries ermöglichen es Ihnen zu wählen, welche einzigartigen CDR (Complimentary Defining Regions - komplementäre definierende Regionen)-Sequenzen in die Wahl Ihres Frameworks integriert werden sollen.</p> <p>Bei jeder CDR kann eine Codonoptimierung angewendet werden, um die Schaffung von ungewünschten Restriktionsstellen zu vermeiden. Das maschinelle Lernen ist zu einem festen Bestandteil der wissenschaftlichen Forschung geworden und wurde als Instrument zur Analyse von Antikörper-Libraries und zur Identifizierung einzigartiger CDR-Kombinationen eingesetzt, die beispielsweise eine höhere Affinität und Spezifität ergeben würden. </p> <p>Zusammen mit der silikonbasierten Syntheseplattform von Twist können aus der Analyse generierte explizite Library-Kombinationen synthetisiert und nahtlos in eine komplett synthetische Library eingefügt werden, um die Erforschung des Variantenraums weiterzuentwickeln.</p></div> </div> <div class="group-right"> <div class="field field--name-field-cp-df-image field--type-image field--label-hidden field__item"> <img class="twist-lightbox" data-mfp-src="/sites/default/files/2020-12/VariantLibraries-CVL-Design.svg" src="/de/sites/default/files/2020-12/VariantLibraries-CVL-Design.svg" width="700" height="169" alt="Benutzerdefinierte CDR-Libraries" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-table field--type-text-long field--label-hidden field__item"><p><!--td {border: 1px solid #ccc;}br {mso-data-placement:same-cell;}--></p> <p><!--td {border: 1px solid #ccc;}br {mso-data-placement:same-cell;}--></p> <p> </p> </div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-description-figure paragraph--view-mode--default"> <div class="clearfix"> <div class="group-left"> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Klonoption für Librarys</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p><a id="clone"> </a></p> <p><span><span><span><span><span><span>Unsere Plattform ermöglicht die einheitliche Synthese von hochkomplexen Oligonukleotiden, wodurch mögliche Verzerrungen im nachgeschalteten Arbeitsablauf minimiert werden. Unser Wissenschaftlerteam hat eine Strategie entwickelt, um diese Einheitlichkeit während der gesamten Library-Herstellung und des Klonens aufrechtzuerhalten. Dies sind Schritte im Arbeitsablauf, die nachweislich zu Verzerrungen führen, die dazu führen können, dass einige Varianten in den Screens/Assays unverhältnismäßig häufig auftauchen. Durch die Beibehaltung der Einheitlichkeit der Ausgangssubstanz und die Minimierung von Ausfällen und unterrepräsentierten Varianten sind unsere geklonten Librarys in der Lage, ein hohes Maß an Diversität aufrechtzuerhalten, was dazu beiträgt, Zeit und Aufwand für das Screening zu reduzieren. </span></span></span></span></span></span></p> <p> </p> </div> </div> <div class="group-right"> <div class="field field--name-field-cp-df-image field--type-image field--label-hidden field__item"> <img class="twist-lightbox" data-mfp-src="/sites/default/files/2022-05/observed-amino-acid-distribution-across-linear-and-cloned-library.svg" src="/de/sites/default/files/2022-05/observed-amino-acid-distribution-across-linear-and-cloned-library.svg" width="700" height="455" alt="Beobachtete Amino" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-table field--type-text-long field--label-hidden field__item"><hr> <p class="text-align-center"><span><span><span><span><span><span>Die Abbildung zeigt die beobachtete Aminosäureverteilung an jeder Variantenposition nach der Herstellung (linear) und nach dem Klonen im Vergleich zur gewünschten Häufigkeit (erwartet).</span></span></span></span></span></span></p> <p> </p> </div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-description-figure paragraph--view-mode--default"> <div class="clearfix"> <div class="group-left"> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Qualitätskontrolle der Libraries mit NGS</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p><span><span><span><span><span><span>Da alle Librarys mit NGS verifiziert werden, können negative Daten verwendet werden, um Mutationen zu identifizieren, die keine verbesserten Funktionen ergeben, und diese können in der nächsten Iteration des Library-Designs entfernt werden.</span></span></span></span></span></span></p> <p><span><span><span><span><span><span>Die Tabelle zeigt die Aminosäurehäufigkeit (%) an vier Stellen einer mutagenen Domäne nach dem linearen Aufbau der Library und nach dem Klonen. Die erwarteten Spalten für jede Position zeigen die gewünschte Häufigkeit jeder Aminosäuresubstitution. Diese Daten zeigen, dass alle erwarteten Varianten an allen Positionen vorhanden waren und die Einheitlichkeit während der gesamten Assemblierung und Klonierung beibehalten wurde.</span></span></span></span></span></span></p> <p><a id="clone"> </a></p> </div> </div> <div class="group-right"> <div class="field field--name-field-cp-df-image field--type-image field--label-hidden field__item"> <img class="twist-lightbox" data-mfp-src="/sites/default/files/2022-05/orf-aa-position%20%282%29.svg" src="/de/sites/default/files/2022-05/orf-aa-position%20%282%29.svg" width="700" height="454" alt="ORF" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </div> </div> </div> <div class="mobile-layer"> <div class="clearfix component-paragraph paragraph paragraph--type--component-description-figure paragraph--view-mode--default"> <div class="clearfix"> <div class="group-left"> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Hochwertige Daten</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Die siliziumbasierte DNA-Syntheseplattform und Library-Technologie von Twist Bioscience bietet Wissenschaftlern qualitativ hochwertige Libraries, die in kürzerer Zeit zuverlässige Daten liefern. Im Vergleich zu zwei anderen konkurrierenden Technologien (Abbildung 1) zeigte die Twist-Library weniger als 1 % Abweichung von der vorgesehenen Aminosäurefrequenz. Zusätzlich zum präzisen Abgleich der vorgesehenen Aminosäureverhältnisse integriert die In-silico-DNA-Syntheseplattform von Twist nahtlos erwünschte Bindungsmotive und Längenvariationen in Multi-Domain-Libraries, was Wissenschaftlern die Möglichkeit gibt, in präziser Weise Variant Libraries zu entwerfen und anzupassen, die eine umfassende Analyse des Variantenraums ermöglichen.</p> <p>Außerdem werden mit Twist-Libraries die für NNK- und TRIM-Libraries typischen Probleme und Schwierigkeiten vermieden. Jede Variante wird Base für Base gedruckt und vor der Synthese überprüft, um Stoppcodons, Haftungsmotive, unerwünschte Mutationen und unerwünschte Verzerrungen bereits zu Beginn des Prozesses zu eliminieren. Dadurch wird die Library mit den gewünschten funktionalen Varianten angereichert und der Aufwand für das Screening verringert.</p> <p>Unsere branchenführenden, sofort einsatzbereiten, hochdiversen und präzise konzipierten Libraries bieten Wissenschaftlern mehr Möglichkeiten, ihre Forschungsziele zu erreichen.</p> </div> </div> <div class="group-right"> <div class="field field--name-field-cp-df-image field--type-image field--label-hidden field__item"> <img class="twist-lightbox" data-mfp-src="/sites/default/files/2021-10/technology-comparison-nnk-vs-trimer-vs-twist_2.svg" src="/de/sites/default/files/2021-10/technology-comparison-nnk-vs-trimer-vs-twist_2.svg" width="700" height="400" alt="Vergleich der Twist-Technologie NNK im Vergleich zu Trimer im Vergleich zu Twist" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-description-figure paragraph--view-mode--default"> <div class="clearfix"> <div class="group-left"> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Überlegene Libraries</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Twist nutzt die eigene Erfahrung mit Molekularbiologie zur präzisen Konstruktion der Variant Libraries. Unser Ansatz der Einzelbasis-Kontrolle ermöglicht es uns, hochdiverse Libraries ohne Motive zu liefern, die Ihre Screening-Prozesse verwirren könnten. Wir liefern vollständig angepasste Libraries von einmaliger Qualität, in denen die gewünschten Varianten zu von den Nutzern definierten Verhältnissen vorhanden sind. Hier sehen Sie ein CVL-Beispiel, welches diese Qualität repräsentiert. Es wurden Varianten in sieben aufeinanderfolgenden Aminosäurepositionen erzeugt, und alle haben die erwarteten Varianten an den gezeigten Positionen, wobei fast alle das gewünschte Verhältnis aufweisen:</p> <p>An den Positionen 1 und 6 sollte die Wildtyp-Aminosäure bei 40 % (Position 1) und 30 % (Position 7) liegen. Für die übrigen 18 Aminosäuren wurde ein Anteil von 3,3 % gefordert.</p> <p>An den Positionen 3 bis 5 sollten die Aminosäurenreste bei 5,3 % liegen, was dann auch beobachtet wurde.</p> </div> </div> <div class="group-right"> <div class="field field--name-field-cp-df-image field--type-image field--label-hidden field__item"> <img class="twist-lightbox" data-mfp-src="/sites/default/files/2020-12/VariantLibraries-CVL-Distribution1.svg" src="/de/sites/default/files/2020-12/VariantLibraries-CVL-Distribution1.svg" width="700" height="430" alt="Variant Library CVL-Verteilung " loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-description-figure paragraph--view-mode--default"> <div class="clearfix"> <div class="group-left"> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Benutzerdefinierte CDR-Libraries</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Unsere Precise Variant Libraries ermöglichen es Ihnen zu wählen, welche einzigartigen CDR (Complimentary Defining Regions - komplementäre definierende Regionen)-Sequenzen in die Wahl Ihres Frameworks integriert werden sollen.</p> <p>Bei jeder CDR kann eine Codonoptimierung angewendet werden, um die Schaffung von ungewünschten Restriktionsstellen zu vermeiden. Das maschinelle Lernen ist zu einem festen Bestandteil der wissenschaftlichen Forschung geworden und wurde als Instrument zur Analyse von Antikörper-Libraries und zur Identifizierung einzigartiger CDR-Kombinationen eingesetzt, die beispielsweise eine höhere Affinität und Spezifität ergeben würden. </p> <p>Zusammen mit der silikonbasierten Syntheseplattform von Twist können aus der Analyse generierte explizite Library-Kombinationen synthetisiert und nahtlos in eine komplett synthetische Library eingefügt werden, um die Erforschung des Variantenraums weiterzuentwickeln.</p></div> </div> <div class="group-right"> <div class="field field--name-field-cp-df-image field--type-image field--label-hidden field__item"> <img class="twist-lightbox" data-mfp-src="/sites/default/files/2020-12/VariantLibraries-CVL-Design.svg" src="/de/sites/default/files/2020-12/VariantLibraries-CVL-Design.svg" width="700" height="169" alt="Benutzerdefinierte CDR-Libraries" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-table field--type-text-long field--label-hidden field__item"><p><!--td {border: 1px solid #ccc;}br {mso-data-placement:same-cell;}--></p> <p><!--td {border: 1px solid #ccc;}br {mso-data-placement:same-cell;}--></p> <p> </p> </div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-description-figure paragraph--view-mode--default"> <div class="clearfix"> <div class="group-left"> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Klonoption für Librarys</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p><a id="clone"> </a></p> <p><span><span><span><span><span><span>Unsere Plattform ermöglicht die einheitliche Synthese von hochkomplexen Oligonukleotiden, wodurch mögliche Verzerrungen im nachgeschalteten Arbeitsablauf minimiert werden. Unser Wissenschaftlerteam hat eine Strategie entwickelt, um diese Einheitlichkeit während der gesamten Library-Herstellung und des Klonens aufrechtzuerhalten. Dies sind Schritte im Arbeitsablauf, die nachweislich zu Verzerrungen führen, die dazu führen können, dass einige Varianten in den Screens/Assays unverhältnismäßig häufig auftauchen. Durch die Beibehaltung der Einheitlichkeit der Ausgangssubstanz und die Minimierung von Ausfällen und unterrepräsentierten Varianten sind unsere geklonten Librarys in der Lage, ein hohes Maß an Diversität aufrechtzuerhalten, was dazu beiträgt, Zeit und Aufwand für das Screening zu reduzieren. </span></span></span></span></span></span></p> <p> </p> </div> </div> <div class="group-right"> <div class="field field--name-field-cp-df-image field--type-image field--label-hidden field__item"> <img class="twist-lightbox" data-mfp-src="/sites/default/files/2022-05/observed-amino-acid-distribution-across-linear-and-cloned-library.svg" src="/de/sites/default/files/2022-05/observed-amino-acid-distribution-across-linear-and-cloned-library.svg" width="700" height="455" alt="Beobachtete Amino" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-table field--type-text-long field--label-hidden field__item"><hr> <p class="text-align-center"><span><span><span><span><span><span>Die Abbildung zeigt die beobachtete Aminosäureverteilung an jeder Variantenposition nach der Herstellung (linear) und nach dem Klonen im Vergleich zur gewünschten Häufigkeit (erwartet).</span></span></span></span></span></span></p> <p> </p> </div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-description-figure paragraph--view-mode--default"> <div class="clearfix"> <div class="group-left"> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Qualitätskontrolle der Libraries mit NGS</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p><span><span><span><span><span><span>Da alle Librarys mit NGS verifiziert werden, können negative Daten verwendet werden, um Mutationen zu identifizieren, die keine verbesserten Funktionen ergeben, und diese können in der nächsten Iteration des Library-Designs entfernt werden.</span></span></span></span></span></span></p> <p><span><span><span><span><span><span>Die Tabelle zeigt die Aminosäurehäufigkeit (%) an vier Stellen einer mutagenen Domäne nach dem linearen Aufbau der Library und nach dem Klonen. Die erwarteten Spalten für jede Position zeigen die gewünschte Häufigkeit jeder Aminosäuresubstitution. Diese Daten zeigen, dass alle erwarteten Varianten an allen Positionen vorhanden waren und die Einheitlichkeit während der gesamten Assemblierung und Klonierung beibehalten wurde.</span></span></span></span></span></span></p> <p><a id="clone"> </a></p> </div> </div> <div class="group-right"> <div class="field field--name-field-cp-df-image field--type-image field--label-hidden field__item"> <img class="twist-lightbox" data-mfp-src="/sites/default/files/2022-05/orf-aa-position%20%282%29.svg" src="/de/sites/default/files/2022-05/orf-aa-position%20%282%29.svg" width="700" height="454" alt="ORF" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field__item select-picker-2" data-id="2"> <div class="no-custom-show-more paragraph paragraph--type--section-tabs paragraph--view-mode--default array" data-style="array"> <div class="field field--name-field-cp-title field--type-string field--label-hidden field__item" id="ordering">Bestellung</div> <div class="field field--name-field-cp-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="desktop-layer"> <div class="container"> <div class="virtual-wrapper row"> <div class="virtual-region-left col-md-7"> <div class="clearfix component-paragraph paragraph paragraph--type--component-text paragraph--view-mode--default"> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><h4>Eine neue Art, Ihre Librarys zu gestalten</h4> <p>Das neue Library Design Tool ist Ihre Komplettlösung, mit der Sie den Design- und Bestellprozess von DNA-Librarys rationalisieren, optimieren und beschleunigen können.</p> <p><a class="banner-cta-button button hero cta" href="https://ecommerce.twistdna.com/app/">Design jetzt starten</a></p> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img srcset="https://www.twistbioscience.com/sites/default/files/styles/original/public/2024-05/icon-Design-Companion_1_0.png 1x" width="150" height="150" src="https://www.twistbioscience.com/sites/default/files/2024-05/icon-Design-Companion_1_0.png" alt="Design-Partner" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Design-Partner</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Intuitives, interaktives Portal zum einfachen Hochladen Ihrer Library-Sequenzdatei</div> <div class="field__item">Identifizieren Sie potenzielle Fehler in der Sequenz mit sofortiger Rückmeldung und ermöglichen Sie eine sofortige Validierung der Library.</div> <div class="field__item">Entwürfe für spätere Verwendung speichern</div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img srcset="https://www.twistbioscience.com/sites/default/files/styles/original/public/2024-05/icon-Real-time-Optimization%C2%A0_1.png 1x" width="150" height="150" src="https://www.twistbioscience.com/sites/default/files/2024-05/icon-Real-time-Optimization%C2%A0_1.png" alt="Optimierung in Echtzeit" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Optimierung in Echtzeit</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Fehler werden zur Überprüfung markiert, sodass Sie Probleme schnell und ohne Verzögerungen beheben können.</div> <div class="field__item">Unsere Experten für die Gestaltung von Librarys stehen auch in dieser Phase bereit, um Ihnen bei Fragen zu helfen.</div> <div class="field__item">Mit unserem intuitiven Tool und fachkundiger Unterstützung können wir Ihnen helfen, den schnellsten Weg zu einer validierten, hochwertigen Library zu finden.</div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img srcset="https://www.twistbioscience.com/sites/default/files/styles/original/public/2024-05/icon-Faster-Process_1.png 1x" width="150" height="150" src="https://www.twistbioscience.com/sites/default/files/2024-05/icon-Faster-Process_1.png" alt="Schnellerer Prozess" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Schnellerer Prozess</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Die interaktive Schnittstelle für das Library-Design in Echtzeit unterstützt Sie bei der Optimierung Ihres Library-Designs und der Kosteneffizienz.</div> <div class="field__item">Entwürfe für spätere Verwendung speichern</div> <div class="field__item">Erzeugt automatisch eine Leistungsbeschreibung für Ihren Auftrag und beschleunigt so den gesamten Bestellvorgang.</div> </div> </div> </div> </div> <div class="virtual-region-right col-md-4"> <div class="virtual-region-sticky-col"> <div class="grey clearfix component-paragraph paragraph paragraph--type--component-callout paragraph--view-mode--default"> <div class="field field--name-field-cp-callout-title field--type-string field--label-hidden field__item">Experten-Support nur einen Klick entfernt</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Bei Fragen senden Sie uns bitte eine E-Mail an <a href="library@twistbioscience.com"><span class="__cf_email__" data-cfemail="4925202b3b283b30093d3e203a3d2b20263a2a202c272a2c672a2624">[email protected]</span></a>.</p> </div> </div> </div> </div> <div class="clearfix"></div> </div> </div> <div class="virtual-region-bottom_full"> <section class="section-background mb-5 section-no-pad" style="background-color:transparent;"> <div class="container-fluid"> <div class="row paragraph paragraph--type--section paragraph--view-mode--default" > <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4>Werfen Sie einen Blick auf unser Library Design Tool</h4> <h5>Eine neue Art bei Twist, Ihre Librarys zu gestalten</h5></div> </div> </div> <div class="paragraph col--bleed col-lg-12 col-sm-12 col-12 paragraph--type--column paragraph--view-mode--default"> <div class="tile column-background mt-3 " style="background-color:#354652; "> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph media-type-video paragraph--type--media-text-component paragraph--view-mode--default col-md-10"> <div class="clearfix"> <div class="image-container img-video img-normal"> <div class="field field--name-field-media-text-thumbnail field--type-image field--label-hidden field__item"> <img src="https://www.twistbioscience.com/sites/default/files/2024-05/Screen%20Shot%202024-02-09%20at%202.24%201_0_2.png" width="1440" height="1040" alt="Library Design Tool" loading="lazy" typeof="foaf:Image" /> </div> <div class="video-container"> <div class="field field--name-field-media-text-video-url field--type-video field--label-hidden field__item"><iframe width="854" height="480" frameborder="0" allowfullscreen="allowfullscreen" src="https://www.youtube.com/embed/N2M2RDTZua8?autoplay=0&rel=0&start=0"></iframe> </div> </div> </div> <div class="text-container"> <div class="clearfix text-formatted field field--name-field-media-text-text field--type-text-long field--label-hidden field__item"><h2>Sehen Sie sich die schrittweise Anleitung zur Optimierung Ihrer Sequenzen an</h2> <p><a class="button fw240 transparent-bg white-border white-text" href="https://ecommerce.twistdna.com/app/">Design jetzt starten</a></p> </div> </div> </div> </div> </div> </div> </div> </div> <div class="paragraph col--bleed col-lg-8 col-sm-8 col-12 paragraph--type--column paragraph--view-mode--default"> <div class="tile column-background " style="background-color:transparent; "> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><p> </p> <p> </p> <h4>Legen wir los</h4> <p>Das neue Library Design Tool ist Ihre Komplettlösung, mit der Sie den Design- und Bestellprozess von DNA-Librarys rationalisieren, optimieren und beschleunigen können.</p></div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-left background" style="background-color:transparent"> <div class="inner-wrapper style-1"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="https://www.twistbioscience.com/sites/default/files/2024-05/1_0.png" width="150" height="95" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><h5>Schritt 1</h5> <p>Melden Sie sich bei Ihrem Konto an. Wenn Sie noch kein Konto haben, dauert es nur ein paar Minuten, eines einzurichten!</p></div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-left background" style="background-color:transparent"> <div class="inner-wrapper style-1"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="https://www.twistbioscience.com/sites/default/files/2024-05/Group%20506_0.png" width="150" height="95" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><h5>Schritt 2</h5> <p>Beginnen Sie mit der Gestaltung Ihrer Library im neuen interaktiven Library Design Tool, das einen Schritt-für-Schritt-Assistenten zur Verfügung stellt. Mit dieser Option können Sie Ihre Library in Echtzeit optimieren, indem Sie die Preise in Echtzeit validieren und am Ende des Einreichungsprozesses eine Übersicht über Ihre Leistungsbeschreibung erhalten.</p></div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-left background" style="background-color:transparent"> <div class="inner-wrapper style-1"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="https://www.twistbioscience.com/sites/default/files/2024-05/Group%20519_0.png" width="150" height="95" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><h5>Schritt 3</h5> <p>Sobald der Kunde das Angebot akzeptiert hat, sendet das Librarys-Team das Projekt an das Produktionsteam.</p></div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><p><a class="banner-cta-button button hero cta" href="https://ecommerce.twistdna.com/app/">Design jetzt starten</a></p> <p> </p> <div class="note" data-bg="{"background_color":"#FEF7F1","padding":"16px"}" style="background-color:#FEF7F1;padding:16px;"> <h4>Hinweis:</h4> <p>Das Library Design Tool ist derzeit in der Region APAC nicht verfügbar. Bitte erkundigen Sie sich bei Ihrem lokalen Support-Team nach dem Verfügbarkeitsdatum.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> <div class="mobile-layer"> <div class="clearfix component-paragraph paragraph paragraph--type--component-text paragraph--view-mode--default"> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><h4>Eine neue Art, Ihre Librarys zu gestalten</h4> <p>Das neue Library Design Tool ist Ihre Komplettlösung, mit der Sie den Design- und Bestellprozess von DNA-Librarys rationalisieren, optimieren und beschleunigen können.</p> <p><a class="banner-cta-button button hero cta" href="https://ecommerce.twistdna.com/app/">Design jetzt starten</a></p> </div> </div> <div class="grey clearfix component-paragraph paragraph paragraph--type--component-callout paragraph--view-mode--default"> <div class="field field--name-field-cp-callout-title field--type-string field--label-hidden field__item">Experten-Support nur einen Klick entfernt</div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Bei Fragen senden Sie uns bitte eine E-Mail an <a href="library@twistbioscience.com"><span class="__cf_email__" data-cfemail="7e12171c0c1f0c073e0a09170d0a1c17110d1d171b101d1b501d1113">[email protected]</span></a>.</p> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img srcset="https://www.twistbioscience.com/sites/default/files/styles/original/public/2024-05/icon-Design-Companion_1_0.png 1x" width="150" height="150" src="https://www.twistbioscience.com/sites/default/files/2024-05/icon-Design-Companion_1_0.png" alt="Design-Partner" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Design-Partner</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Intuitives, interaktives Portal zum einfachen Hochladen Ihrer Library-Sequenzdatei</div> <div class="field__item">Identifizieren Sie potenzielle Fehler in der Sequenz mit sofortiger Rückmeldung und ermöglichen Sie eine sofortige Validierung der Library.</div> <div class="field__item">Entwürfe für spätere Verwendung speichern</div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img srcset="https://www.twistbioscience.com/sites/default/files/styles/original/public/2024-05/icon-Real-time-Optimization%C2%A0_1.png 1x" width="150" height="150" src="https://www.twistbioscience.com/sites/default/files/2024-05/icon-Real-time-Optimization%C2%A0_1.png" alt="Optimierung in Echtzeit" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Optimierung in Echtzeit</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Fehler werden zur Überprüfung markiert, sodass Sie Probleme schnell und ohne Verzögerungen beheben können.</div> <div class="field__item">Unsere Experten für die Gestaltung von Librarys stehen auch in dieser Phase bereit, um Ihnen bei Fragen zu helfen.</div> <div class="field__item">Mit unserem intuitiven Tool und fachkundiger Unterstützung können wir Ihnen helfen, den schnellsten Weg zu einer validierten, hochwertigen Library zu finden.</div> </div> </div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-benefit paragraph--view-mode--default"> <div class="clearfix"> <div style="background-color:rgb(254,239,225);" class="field field--name-field-cp-benefit-image field--type-image field--label-hidden field__item"> <img srcset="https://www.twistbioscience.com/sites/default/files/styles/original/public/2024-05/icon-Faster-Process_1.png 1x" width="150" height="150" src="https://www.twistbioscience.com/sites/default/files/2024-05/icon-Faster-Process_1.png" alt="Schnellerer Prozess" loading="lazy" typeof="foaf:Image" /> </div> <div class="field field--name-field-component-headline field--type-string field--label-hidden field__item">Schnellerer Prozess</div> <div class="field field--name-field-cp-benefit-detail-text field--type-string field--label-hidden field__items"> <div class="field__item">Die interaktive Schnittstelle für das Library-Design in Echtzeit unterstützt Sie bei der Optimierung Ihres Library-Designs und der Kosteneffizienz.</div> <div class="field__item">Entwürfe für spätere Verwendung speichern</div> <div class="field__item">Erzeugt automatisch eine Leistungsbeschreibung für Ihren Auftrag und beschleunigt so den gesamten Bestellvorgang.</div> </div> </div> </div> <section class="section-background mb-5 section-no-pad" style="background-color:transparent;"> <div class="container-fluid"> <div class="row paragraph paragraph--type--section paragraph--view-mode--default" > <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4>Werfen Sie einen Blick auf unser Library Design Tool</h4> <h5>Eine neue Art bei Twist, Ihre Librarys zu gestalten</h5></div> </div> </div> <div class="paragraph col--bleed col-lg-12 col-sm-12 col-12 paragraph--type--column paragraph--view-mode--default"> <div class="tile column-background mt-3 " style="background-color:#354652; "> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph media-type-video paragraph--type--media-text-component paragraph--view-mode--default col-md-10"> <div class="clearfix"> <div class="image-container img-video img-normal"> <div class="field field--name-field-media-text-thumbnail field--type-image field--label-hidden field__item"> <img src="https://www.twistbioscience.com/sites/default/files/2024-05/Screen%20Shot%202024-02-09%20at%202.24%201_0_2.png" width="1440" height="1040" alt="Library Design Tool" loading="lazy" typeof="foaf:Image" /> </div> <div class="video-container"> <div class="field field--name-field-media-text-video-url field--type-video field--label-hidden field__item"><iframe width="854" height="480" frameborder="0" allowfullscreen="allowfullscreen" src="https://www.youtube.com/embed/N2M2RDTZua8?autoplay=0&rel=0&start=0"></iframe> </div> </div> </div> <div class="text-container"> <div class="clearfix text-formatted field field--name-field-media-text-text field--type-text-long field--label-hidden field__item"><h2>Sehen Sie sich die schrittweise Anleitung zur Optimierung Ihrer Sequenzen an</h2> <p><a class="button fw240 transparent-bg white-border white-text" href="https://ecommerce.twistdna.com/app/">Design jetzt starten</a></p> </div> </div> </div> </div> </div> </div> </div> </div> <div class="paragraph col--bleed col-lg-8 col-sm-8 col-12 paragraph--type--column paragraph--view-mode--default"> <div class="tile column-background " style="background-color:transparent; "> <div class="field field--name-field-paragraph-components field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><p> </p> <p> </p> <h4>Legen wir los</h4> <p>Das neue Library Design Tool ist Ihre Komplettlösung, mit der Sie den Design- und Bestellprozess von DNA-Librarys rationalisieren, optimieren und beschleunigen können.</p></div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-left background" style="background-color:transparent"> <div class="inner-wrapper style-1"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="https://www.twistbioscience.com/sites/default/files/2024-05/1_0.png" width="150" height="95" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><h5>Schritt 1</h5> <p>Melden Sie sich bei Ihrem Konto an. Wenn Sie noch kein Konto haben, dauert es nur ein paar Minuten, eines einzurichten!</p></div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-left background" style="background-color:transparent"> <div class="inner-wrapper style-1"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="https://www.twistbioscience.com/sites/default/files/2024-05/Group%20506_0.png" width="150" height="95" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><h5>Schritt 2</h5> <p>Beginnen Sie mit der Gestaltung Ihrer Library im neuen interaktiven Library Design Tool, das einen Schritt-für-Schritt-Assistenten zur Verfügung stellt. Mit dieser Option können Sie Ihre Library in Echtzeit optimieren, indem Sie die Preise in Echtzeit validieren und am Ende des Einreichungsprozesses eine Übersicht über Ihre Leistungsbeschreibung erhalten.</p></div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-left background" style="background-color:transparent"> <div class="inner-wrapper style-1"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="https://www.twistbioscience.com/sites/default/files/2024-05/Group%20519_0.png" width="150" height="95" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><h5>Schritt 3</h5> <p>Sobald der Kunde das Angebot akzeptiert hat, sendet das Librarys-Team das Projekt an das Produktionsteam.</p></div> </div> </div> </div> <div class="field__item"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><p><a class="banner-cta-button button hero cta" href="https://ecommerce.twistdna.com/app/">Design jetzt starten</a></p> <p> </p> <div class="note" data-bg="{"background_color":"#FEF7F1","padding":"16px"}" style="background-color:#FEF7F1;padding:16px;"> <h4>Hinweis:</h4> <p>Das Library Design Tool ist derzeit in der Region APAC nicht verfügbar. Bitte erkundigen Sie sich bei Ihrem lokalen Support-Team nach dem Verfügbarkeitsdatum.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> </div> </div> <div class="field__item select-picker-3" data-id="3"> <div class="no-custom-show-more paragraph paragraph--type--section-tabs paragraph--view-mode--default array" data-style="array"> <div class="field field--name-field-cp-title field--type-string field--label-hidden field__item" id="resources">RESSOURCEN</div> <div class="field field--name-field-cp-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="desktop-layer"> <div class="container"> <div class="virtual-wrapper row"> <div class="virtual-region-left col-md-12"> <div class="component_link_accordion accordion accordion-flush" id="accordionFlushExample"><div class="accordion-item"><div class="accordion-header accordion-button collapsed" id="flush-406" data-bs-toggle="collapse" data-bs-target="#flush-collapse-406" aria-expanded="false" aria-controls="flush-collapse-406"><img src="https://www.twistbioscience.com/de/sites/default/files/2019-06/dark-datasheet-slate.svg" alt="" class="me-2" />Produktblatt</div><div id="flush-collapse-406" class="accordion-collapse collapse" aria-labelledby="flush-406" data-bs-parent="#accordionFlushExample"><div class="accordion-body"> <div class="clearfix component-paragraph paragraph paragraph--type--component-link paragraph--view-mode--default"> <div class="field field--name-field-cp-link-link field--type-link field--label-hidden field__item"><a href="/de/resources/product-sheet/combinatorial-variant-libraries" target="_blank">Herunterladen </a></div> <div class="field field--name-field-cp-link-resource-type field--type-entity-reference field--label-hidden field__item"><div about="/taxonomy/term/406" id="taxonomy-term-406" class="taxonomy-term vocabulary-resource-types"> <h2> <div class="field field--name-name field--type-string field--label-hidden field__item">Produktblatt</div> </h2> <div class="content"> <div class="field field--name-field-resource-icon-dark field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2019-06/dark-datasheet-slate.svg" alt="Produktblatt" loading="lazy" typeof="Image" /> </div> </div> </div> </div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>CVL-Produktblatt</p></div> </div> </div><div class="accordion-body"> <div class="clearfix component-paragraph paragraph paragraph--type--component-link paragraph--view-mode--default"> <div class="field field--name-field-cp-link-link field--type-link field--label-hidden field__item"><a href="/de/resources/product-sheet/variant-libraries-product-brochure" target="_blank">Herunterladen </a></div> <div class="field field--name-field-cp-link-resource-type field--type-entity-reference field--label-hidden field__item"><div about="/taxonomy/term/406" id="taxonomy-term-406" class="taxonomy-term vocabulary-resource-types"> <h2> <div class="field field--name-name field--type-string field--label-hidden field__item">Produktblatt</div> </h2> <div class="content"> <div class="field field--name-field-resource-icon-dark field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2019-06/dark-datasheet-slate.svg" alt="Produktblatt" loading="lazy" typeof="Image" /> </div> </div> </div> </div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p><span><span><span><span><span><span>Variant Library-Produktbroschüre</span></span></span></span></span></span></p></div> </div> </div></div></div><div class="accordion-item"><div class="accordion-header accordion-button collapsed" id="flush-436" data-bs-toggle="collapse" data-bs-target="#flush-collapse-436" aria-expanded="false" aria-controls="flush-collapse-436"><img src="https://www.twistbioscience.com/de/sites/default/files/2020-08/dark-webinar-slate.svg" alt="" class="me-2" />Webinar</div><div id="flush-collapse-436" class="accordion-collapse collapse" aria-labelledby="flush-436" data-bs-parent="#accordionFlushExample"><div class="accordion-body"> <div class="clearfix component-paragraph paragraph paragraph--type--component-link paragraph--view-mode--default"> <div class="field field--name-field-cp-link-link field--type-link field--label-hidden field__item"><a href="/de/resources/webinar/precision-variant-library-technology-allows-focused-screening" target="_blank">Herunterladen </a></div> <div class="field field--name-field-cp-link-resource-type field--type-entity-reference field--label-hidden field__item"><div about="/taxonomy/term/436" id="taxonomy-term-436" class="taxonomy-term vocabulary-resource-types"> <h2> <div class="field field--name-name field--type-string field--label-hidden field__item">Webinar</div> </h2> <div class="content"> <div class="field field--name-field-resource-icon-dark field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2020-08/dark-webinar-slate.svg" alt="Webinar" loading="lazy" typeof="Image" /> </div> </div> </div> </div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p><span><span><span><span><span><span>Variant Library-Präzisionstechnologie ermöglicht zielgerichtete Analysen</span></span></span></span></span></span></p></div> </div> </div></div></div><div class="accordion-item"><div class="accordion-header accordion-button collapsed" id="flush-1061" data-bs-toggle="collapse" data-bs-target="#flush-collapse-1061" aria-expanded="false" aria-controls="flush-collapse-1061"><img src="https://www.twistbioscience.com/de/sites/default/files/2023-04/flyer-icon-dark.svg" alt="" class="me-2" />Flyer</div><div id="flush-collapse-1061" class="accordion-collapse collapse" aria-labelledby="flush-1061" data-bs-parent="#accordionFlushExample"><div class="accordion-body"> <div class="clearfix component-paragraph paragraph paragraph--type--component-link paragraph--view-mode--default"> <div class="field field--name-field-cp-link-link field--type-link field--label-hidden field__item"><a href="https://www.twistbioscience.com/de/resources/flyer/introducing-new-twist-libraries-design-tool" target="_blank">Herunterladen </a></div> <div class="field field--name-field-cp-link-resource-type field--type-entity-reference field--label-hidden field__item"><div about="/taxonomy/term/1061" id="taxonomy-term-1061" class="taxonomy-term vocabulary-resource-types"> <h2> <div class="field field--name-name field--type-string field--label-hidden field__item">Flyer</div> </h2> <div class="content"> <div class="field field--name-field-resource-icon-dark field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2023-04/flyer-icon-dark.svg" alt="Flyer" loading="lazy" typeof="Image" /> </div> </div> </div> </div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Einführung in das neue Library Design Tool von Twist</p></div> </div> </div></div></div></div> </div> <div class="clearfix"></div> </div> </div> </div> <div class="mobile-layer"> <div class="clearfix component-paragraph paragraph paragraph--type--component-link paragraph--view-mode--default"> <div class="field field--name-field-cp-link-link field--type-link field--label-hidden field__item"><a href="/de/resources/product-sheet/combinatorial-variant-libraries" target="_blank">Herunterladen </a></div> <div class="field field--name-field-cp-link-resource-type field--type-entity-reference field--label-hidden field__item"><div about="/taxonomy/term/406" id="taxonomy-term-406" class="taxonomy-term vocabulary-resource-types"> <h2> <div class="field field--name-name field--type-string field--label-hidden field__item">Produktblatt</div> </h2> <div class="content"> <div class="field field--name-field-resource-icon-dark field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2019-06/dark-datasheet-slate.svg" alt="Produktblatt" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>CVL-Produktblatt</p></div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-link paragraph--view-mode--default"> <div class="field field--name-field-cp-link-link field--type-link field--label-hidden field__item"><a href="/de/resources/webinar/precision-variant-library-technology-allows-focused-screening" target="_blank">Herunterladen </a></div> <div class="field field--name-field-cp-link-resource-type field--type-entity-reference field--label-hidden field__item"><div about="/taxonomy/term/436" id="taxonomy-term-436" class="taxonomy-term vocabulary-resource-types"> <h2> <div class="field field--name-name field--type-string field--label-hidden field__item">Webinar</div> </h2> <div class="content"> <div class="field field--name-field-resource-icon-dark field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2020-08/dark-webinar-slate.svg" alt="Webinar" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p><span><span><span><span><span><span>Variant Library-Präzisionstechnologie ermöglicht zielgerichtete Analysen</span></span></span></span></span></span></p></div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-link paragraph--view-mode--default"> <div class="field field--name-field-cp-link-link field--type-link field--label-hidden field__item"><a href="/de/resources/product-sheet/variant-libraries-product-brochure" target="_blank">Herunterladen </a></div> <div class="field field--name-field-cp-link-resource-type field--type-entity-reference field--label-hidden field__item"><div about="/taxonomy/term/406" id="taxonomy-term-406" class="taxonomy-term vocabulary-resource-types"> <h2> <div class="field field--name-name field--type-string field--label-hidden field__item">Produktblatt</div> </h2> <div class="content"> <div class="field field--name-field-resource-icon-dark field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2019-06/dark-datasheet-slate.svg" alt="Produktblatt" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p><span><span><span><span><span><span>Variant Library-Produktbroschüre</span></span></span></span></span></span></p></div> </div> <div class="clearfix component-paragraph paragraph paragraph--type--component-link paragraph--view-mode--default"> <div class="field field--name-field-cp-link-link field--type-link field--label-hidden field__item"><a href="https://www.twistbioscience.com/de/resources/flyer/introducing-new-twist-libraries-design-tool" target="_blank">Herunterladen </a></div> <div class="field field--name-field-cp-link-resource-type field--type-entity-reference field--label-hidden field__item"><div about="/taxonomy/term/1061" id="taxonomy-term-1061" class="taxonomy-term vocabulary-resource-types"> <h2> <div class="field field--name-name field--type-string field--label-hidden field__item">Flyer</div> </h2> <div class="content"> <div class="field field--name-field-resource-icon-dark field--type-image field--label-hidden field__item"> <img src="/de/sites/default/files/2023-04/flyer-icon-dark.svg" alt="Flyer" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><p>Einführung in das neue Library Design Tool von Twist</p></div> </div> </div> </div> </div> </div> </div> <div class="header-right-container"> <div class="field field--name-field-pc-tag-line field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--component-tagline paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-cp-mobile-text field--type-text field--label-hidden field__item">Eliminierung der Verzerrung und unerwünschter Motive</div> <div class="clearfix text-formatted field field--name-field-cp-tablet-text field--type-text field--label-hidden field__item">Eliminierung der Verzerrung und unerwünschter Motive</div> <div class="clearfix text-formatted field field--name-field-cp-desktop-text field--type-text field--label-hidden field__item">Eliminierung der Verzerrung und unerwünschter Motive</div> </div> </div> <div class="field field--name-field-pc-link-button field--type-link field--label-hidden field__item"><a href="https://designer.twistbioscience.com/library-designs" id="ordernow">DESIGN STARTEN</a></div> </div> </div> </article> </div> </div> <div id="block-twist-barrio-intercomblock" class="block block-twist-custom block-intercom"> <div class="content"> <script data-cfasync="false" src="/de/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script> const APP_ID = "juitcz5w"; window.intercomSettings = { app_id: APP_ID, background_color: "#333333", } </script> <script src="/de/modules/custom/twist_custom/js/intercom/intercom-facade.min.js"></script> </div> </div> <div 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