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} </style> <meta name="follow.it-verification-code-YjBieUhIbjlSaTlwVGJ3TCttMnFRWTNDY2NxN1pUUlpTN2hkZm9zZ1BSTHdJTE1NVFZmU2I5MkF4Z1RPK3FqN0lNR2Vjd1l3NVE3eC9hVzJCR092MUhxNVY3ek52SlpyQ2kvdm9MUXViT0FYdSs1eW1YeWtYdEg3RFRqNm1lMEV8bzBEc0VDNjlTMzdxb3FrOUdNYzJrbmxEbEtaQlI5WTNGQTZIc3VQQVo5ND0=" content="d4BS8a1CMehBt5r4ASFd"/> <meta name="viewport" content="width=device-width, initial-scale=1"><meta property="og:image:secure_url" content="https://tron-mainz.de/de/wp-content/uploads/sites/9/2021/02/SARSCoV2_BioRxiv.png" data-id="sfsi-plus"/><meta property="og:image:type" content="" data-id="sfsi-plus"/><meta property="og:image:width" content="1200" data-id="sfsi-plus"/><meta property="og:image:height" content="360" data-id="sfsi-plus"/><meta property="og:description" content="Within the last year, a few infections with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) quickly turned into the global COVID-19 pandemic infecting and threatening death for millions of people all over the globe. The viral spike protein is responsible for viral binding and entry to host cells and thus mediates infection. Hence, the protein is also of particular interest and the major target for recently approved mRNA vaccines or neutralizing antibodies. In this study, Barbara Schr枚rs and her colleagues gathered 147,413 genomic assemblies and 2,393 NGS sequencing datasets to detect non-synonymous spike protein mutations and infer their frequency within a given sample and the effect on potential antibody binding sites and known T cell epitopes. They confirm a low mutation rate, but also discovered an increase of mutation rates of the spike protein over time. In addition, some of the discovered mutations might have an effect on antibody binding or T-cell recognition and thus have an impact on the efficacy of current or upcoming vaccines. The authors conclude that the results demonstrate the increasing importance of monitoring SARS-CoV-2 sequences for an early detection of variants that require adaptations in preventive and therapeutic strategies. The study was published as a pre-print in BioRxiv (https://www.biorxiv.org/content/10.1101/2021.02.04.429765v1). 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type="submit" class="fa fa-search submit" name="submit" value="Search"></button> </form> <div class="fix"></div> </div></div> </li> </ul> </li> </ul> </div> </section> <a href="#top" class="nav-close"> <i class="fa fa-times"></i> <span>Return to Content</span> </a> </nav> </div> </header> </div>  <div id="content" class="col-full"> <div id="main-sidebar-container">  <section id="main"> <article class="post-9307 post type-post status-publish format-standard has-post-thumbnail hentry category-spotlight-2017"> <header> <h1 class="title entry-title">Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates</h1> </header> <div class="post-meta"><span class="small">By</span> <span class="author vcard"><span class="fn"><a href="https://web.archive.org/web/20210415105652/https://tron-mainz.de/de/blog/author/thomas/" title="Beitr盲ge von thomas" rel="author">thomas</a></span></span> <span class="small">on</span> <abbr class="date time published updated" title="2021-02-05T07:43:47+0100">5. Februar 2021</abbr> <span class="small">in</span> <span class="categories"><a href="https://web.archive.org/web/20210415105652/https://tron-mainz.de/de/blog/category/spotlight-2017/" title="View all items in spotlight-2017">spotlight-2017</a></span> </div> <section class="entry"> <p>Within the last year, a few infections with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) quickly turned into the global COVID-19 pandemic infecting and threatening death for millions of people all over the globe. The viral spike protein is responsible for viral binding and entry to host cells and thus mediates infection. Hence, the protein is also of particular interest and the major target for recently approved mRNA vaccines or neutralizing antibodies.<br/> In this study, Barbara Schr枚rs and her colleagues gathered 147,413 genomic assemblies and 2,393 NGS sequencing datasets to detect non-synonymous spike protein mutations and infer their frequency within a given sample and the effect on potential antibody binding sites and known T cell epitopes. They confirm a low mutation rate, but also discovered an increase of mutation rates of the spike protein over time. In addition, some of the discovered mutations might have an effect on antibody binding or T-cell recognition and thus have an impact on the efficacy of current or upcoming vaccines.<br/> The authors conclude that the results demonstrate the increasing importance of monitoring SARS-CoV-2 sequences for an early detection of variants that require adaptations in preventive and therapeutic strategies.</p> <p>The study was published as a pre-print in BioRxiv (<a href="https://web.archive.org/web/20210415105652/https://www.biorxiv.org/content/10.1101/2021.02.04.429765v1">https://www.biorxiv.org/content/10.1101/2021.02.04.429765v1</a>).</p> [Image: SARS-CoV-2 spike-glycoprotein (PDB: <a href="https://web.archive.org/web/20210415105652/https://pdb101.rcsb.org/motm/246">https://pdb101.rcsb.org/motm/246</a>)] </section> <div class="fix"></div> <div class="post-utility"></div> </article> <div class="post-entries"> <div class="nav-prev fl"><a href="https://web.archive.org/web/20210415105652/https://tron-mainz.de/de/blog/2021/02/01/akademiepreis-des-landes-rheinland-pfalz-fuer-ugur-sahin-und-oezlem-tuereci/" rel="prev"><i class="fa fa-angle-left"></i> Akademiepreis des Landes Rheinland-Pfalz f眉r Ugur Sahin und 脰zlem T眉reci</a></div> <div class="nav-next fr"><a href="https://web.archive.org/web/20210415105652/https://tron-mainz.de/de/blog/2021/02/22/iodine-124-pet-quantification-of-organ-specific-delivery-and-expression-of-nis-encoding-rna/" rel="next">Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA <i class="fa fa-angle-right"></i></a></div> <div class="fix"></div> </div> </section> <aside id="sidebar"> <div id="recent-posts-2" class="widget widget_recent_entries"> <h3>Recent News</h3> <ul> <li> <a href="https://web.archive.org/web/20210415105652/https://tron-mainz.de/de/blog/2021/03/01/bundesverdienstkreuz-fuer-ugur-sahin-und-oezlem-tuereci/">Bundesverdienstkreuz f眉r Ugur Sahin und 脰zlem T眉reci</a> </li> <li> <a href="https://web.archive.org/web/20210415105652/https://tron-mainz.de/de/blog/2021/02/22/iodine-124-pet-quantification-of-organ-specific-delivery-and-expression-of-nis-encoding-rna/">Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA</a> </li> <li> <a href="https://web.archive.org/web/20210415105652/https://tron-mainz.de/de/blog/2021/02/05/large-scale-analysis-of-sars-cov-2-spike-glycoprotein-mutants-demonstrates-the-need-for-continuous-screening-of-virus-isolates/" aria-current="page">Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates</a> </li> <li> <a href="https://web.archive.org/web/20210415105652/https://tron-mainz.de/de/blog/2021/02/01/akademiepreis-des-landes-rheinland-pfalz-fuer-ugur-sahin-und-oezlem-tuereci/">Akademiepreis des Landes Rheinland-Pfalz f眉r Ugur Sahin und 脰zlem T眉reci</a> </li> <li> <a 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