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class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Lectin C-type domain</th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:PDB_1jzn_EBI.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/PDB_1jzn_EBI.jpg/220px-PDB_1jzn_EBI.jpg" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/PDB_1jzn_EBI.jpg/330px-PDB_1jzn_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/PDB_1jzn_EBI.jpg/440px-PDB_1jzn_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span><div class="infobox-caption">Pentameric structure of rattlesnake venom lectin which is a galactose binding lectin.<sup id="cite_ref-pmid15049685_1-0" class="reference"><a href="#cite_note-pmid15049685-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> <sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">Lectin_C</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a></th><td class="infobox-data pfam" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF00059">PF00059</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/InterPro" title="InterPro">InterPro</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR001304">IPR001304</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Simple_Modular_Architecture_Research_Tool" title="Simple Modular Architecture Research Tool">SMART</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=CLECT">CLECT</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/PROSITE" title="PROSITE">PROSITE</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://prosite.expasy.org/PS50041">PS50041</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Structural_Classification_of_Proteins" class="mw-redirect" title="Structural Classification of Proteins">SCOP2</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://scop2.mrc-lmb.cam.ac.uk/search?t=txt;q=2msb">2msb</a> / <a rel="nofollow" class="external text" href="https://scop.berkeley.edu/pdb/code=2msb">SCOPe</a> / <a rel="nofollow" class="external text" href="http://supfam.org/SUPERFAMILY/cgi-bin/search.cgi?search_field=2msb">SUPFAM</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Conserved_Domain_Database" title="Conserved Domain Database">CDD</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00037">cd00037</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Available protein structures:</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Pfam" title="Pfam">Pfam</a>  </th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="http://pfam.xfam.org/family/PF00059?tab=pdbBlock">structures</a> / <a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/search?kw=PF00059">ECOD</a>  </td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_annotation.annotation_id:PF00059%20AND%20rcsb_polymer_entity_annotation.type:Pfam">RCSB PDB</a>; <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?pfam_accession:PF00059">PDBe</a>; <a rel="nofollow" class="external text" href="https://pdbj.org/search/pdb?other_db_select=PFam&other_db_field=PF00059">PDBj</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PDBsum" title="PDBsum">PDBsum</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF00059">structure summary</a></td></tr></tbody></table></td></tr></tbody></table> <p>A <b>C-type lectin</b> (<b>CLEC</b>) is a type of carbohydrate-binding <a href="/wiki/Protein" title="Protein">protein</a> known as a <a href="/wiki/Lectin" title="Lectin">lectin</a>.<sup id="cite_ref-pmid16336259_3-0" class="reference"><a href="#cite_note-pmid16336259-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> The C-type designation is from their requirement for <a href="/wiki/Calcium" title="Calcium">calcium</a> for binding.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a>.<sup id="cite_ref-pmid10508765_5-0" class="reference"><a href="#cite_note-pmid10508765-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid19439262_6-0" class="reference"><a href="#cite_note-pmid19439262-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Classification">Classification</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=C-type_lectin&action=edit&section=1" title="Edit section: Classification"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Drickamer <i>et al.</i> classified C-type lectins into 7 subgroups (I to VII) based on the order of the various <a href="/wiki/Protein_domains" class="mw-redirect" title="Protein domains">protein domains</a> in each protein.<sup id="cite_ref-pmid8341801_7-0" class="reference"><a href="#cite_note-pmid8341801-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV).<sup id="cite_ref-pmid12655774_8-0" class="reference"><a href="#cite_note-pmid12655774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Most recently, three further subgroups were added (XV to XVII).<sup id="cite_ref-pmid16336259_3-1" class="reference"><a href="#cite_note-pmid16336259-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <table class="wikitable"> <tbody><tr> <th>Group</th> <th>Name</th> <th>Associated domains </th></tr> <tr> <td>I</td> <td><a href="/wiki/Lectican" title="Lectican">Lecticans</a></td> <td><a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF</a>, <a href="/wiki/Apolipoprotein_H#Sushi_2_protein_domain" title="Apolipoprotein H">Sushi</a>, Ig and Link domains </td></tr> <tr> <td>II</td> <td><a href="/wiki/Asialoglycoprotein" title="Asialoglycoprotein">Asialoglycoprotein</a> and DC receptors</td> <td>None </td></tr> <tr> <td>III</td> <td><a href="/wiki/Collectin" title="Collectin">Collectins</a></td> <td>None </td></tr> <tr> <td>IV</td> <td><a href="/wiki/Selectin" title="Selectin">Selectins</a></td> <td><a href="/wiki/Apolipoprotein_H#Sushi_2_protein_domain" title="Apolipoprotein H">Sushi</a> and <a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF</a> domains </td></tr> <tr> <td>V</td> <td><a href="/wiki/Natural_killer_cell" title="Natural killer cell">NK - cell</a> receptors</td> <td>None </td></tr> <tr> <td>VI</td> <td>Multi-CTLD endocytic receptors</td> <td>FnII and Ricin domains </td></tr> <tr> <td>VII</td> <td>Reg group</td> <td>None </td></tr> <tr> <td>VIII</td> <td><a href="/wiki/Chondrolectin" class="mw-redirect" title="Chondrolectin">Chondrolectin</a>, <a href="/wiki/Layilin" title="Layilin">Layilin</a></td> <td>None </td></tr> <tr> <td>IX</td> <td><a href="/wiki/Tetranectin" class="mw-redirect" title="Tetranectin">Tetranectin</a></td> <td>None </td></tr> <tr> <td>X</td> <td><a href="/wiki/PKD1" class="mw-redirect" title="PKD1">Polycystin</a></td> <td>WSC, REJ, PKD domains </td></tr> <tr> <td>XI</td> <td>Attractin (<a href="/wiki/ATRN" class="mw-redirect" title="ATRN">ATRN</a>)</td> <td>PSI, <a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF</a> and CUB domains </td></tr> <tr> <td>XII</td> <td><a href="/wiki/Major_basic_protein" title="Major basic protein">Eosinophil major basic protein</a> (EMBP)</td> <td>None </td></tr> <tr> <td>XIII</td> <td><a href="/wiki/DGCR2" title="DGCR2">DGCR2</a></td> <td>None </td></tr> <tr> <td>XIV</td> <td><a href="/wiki/Thrombomodulin" title="Thrombomodulin">Thrombomodulin</a>, <a href="/wiki/CD93" title="CD93">CD93</a>, <a href="/wiki/CD248" title="CD248">CD248</a>, <a href="/w/index.php?title=CLEC14A&action=edit&redlink=1" class="new" title="CLEC14A (page does not exist)">CLEC14A</a></td> <td><a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF</a> domains <sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>XV</td> <td><a href="/wiki/Bimlec" class="mw-redirect" title="Bimlec">Bimlec</a></td> <td>None </td></tr> <tr> <td>XVI</td> <td>SEEC</td> <td><a href="/wiki/Sterol_carrier_protein" title="Sterol carrier protein">SCP</a> and <a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF</a> domains </td></tr> <tr> <td>XVII</td> <td>CBCP/<a href="/wiki/Frem1" class="mw-redirect" title="Frem1">Frem1</a>/QBRICK</td> <td>CSPG repeats and <a href="/wiki/Calx-beta_motif" title="Calx-beta motif">CalX-beta</a> domains </td></tr></tbody></table> <p>CLECs include: </p> <ul><li><a href="/wiki/CLEC1A" title="CLEC1A">CLEC1A</a>, <a href="/wiki/CLEC1B" title="CLEC1B">CLEC1B</a></li> <li><a href="/w/index.php?title=CLEC2A&action=edit&redlink=1" class="new" title="CLEC2A (page does not exist)">CLEC2A</a>, <a href="/wiki/CLEC2B" title="CLEC2B">CLEC2B</a>, <a href="/wiki/CD69" title="CD69">CD69</a> (CLEC2C), <a href="/wiki/CLEC2D" title="CLEC2D">CLEC2D</a>, <a href="/w/index.php?title=CLEC2L&action=edit&redlink=1" class="new" title="CLEC2L (page does not exist)">CLEC2L</a></li> <li><a href="/w/index.php?title=CLEC3A&action=edit&redlink=1" class="new" title="CLEC3A (page does not exist)">CLEC3A</a>, <a href="/wiki/CLEC3B" title="CLEC3B">CLEC3B</a></li> <li><a href="/wiki/CLEC4A" title="CLEC4A">CLEC4A</a>, <a href="/wiki/CLEC4C" title="CLEC4C">CLEC4C</a>, <a href="/w/index.php?title=CLEC4D&action=edit&redlink=1" class="new" title="CLEC4D (page does not exist)">CLEC4D</a>, <a href="/wiki/CLEC4E" class="mw-redirect" title="CLEC4E">CLEC4E</a>, <a href="/w/index.php?title=CLEC4F&action=edit&redlink=1" class="new" title="CLEC4F (page does not exist)">CLEC4F</a>, <a href="/w/index.php?title=CLEC4G&action=edit&redlink=1" class="new" title="CLEC4G (page does not exist)">CLEC4G</a>, <a href="/wiki/ASGR1" class="mw-redirect" title="ASGR1">ASGR1</a> (CLEC4H1), <a href="/wiki/ASGR2" class="mw-redirect" title="ASGR2">ASGR2</a> (CLEC4H2), <a href="/wiki/FCER2" class="mw-redirect" title="FCER2">FCER2</a> (CLEC4J), <a href="/wiki/CD207" class="mw-redirect" title="CD207">CD207</a> (CLEC4K), <a href="/wiki/CD209" class="mw-redirect" title="CD209">CD209</a> (CLEC4L), <a href="/wiki/CLEC4M" title="CLEC4M">CLEC4M</a></li> <li><a href="/wiki/CLEC5A" title="CLEC5A">CLEC5A</a></li> <li><a href="/wiki/CLEC6A" title="CLEC6A">CLEC6A</a></li> <li><a href="/wiki/CLEC7A" title="CLEC7A">CLEC7A</a></li> <li><a href="/wiki/OLR1" title="OLR1">OLR1</a> (CLEC8A)</li> <li><a href="/wiki/CLEC9A" title="CLEC9A">CLEC9A</a></li> <li><a href="/wiki/CLEC10A" title="CLEC10A">CLEC10A</a></li> <li><a href="/wiki/CLEC11A" title="CLEC11A">CLEC11A</a></li> <li><a href="/wiki/CLEC12A" title="CLEC12A">CLEC12A</a>, <a href="/w/index.php?title=CLEC12B&action=edit&redlink=1" class="new" title="CLEC12B (page does not exist)">CLEC12B</a></li> <li><a href="/wiki/CD302" title="CD302">CD302</a> (CLEC13A), <a href="/wiki/LY75" class="mw-redirect" title="LY75">LY75</a> (CLEC13B), <a href="/wiki/PLA2R1" title="PLA2R1">PLA2R1</a> (CLEC13C), <a href="/wiki/MRC1" class="mw-redirect" title="MRC1">MRC1</a> (CLEC13D), <a href="/wiki/MRC2" class="mw-redirect" title="MRC2">MRC2</a> (CLEC13E)</li> <li><a href="/w/index.php?title=CLEC14A&action=edit&redlink=1" class="new" title="CLEC14A (page does not exist)">CLEC14A</a></li> <li><a href="/wiki/CLEC16A" title="CLEC16A">CLEC16A</a></li> <li><a href="/w/index.php?title=CLEC17A&action=edit&redlink=1" class="new" title="CLEC17A (page does not exist)">CLEC17A</a></li></ul> <p>The "NK Cell lectin-like receptors" are a very closely related group:<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <ul><li><a href="/wiki/KLRA1" title="KLRA1">KLRA1</a></li> <li><a href="/wiki/KLRB1" title="KLRB1">KLRB1</a> (CLEC5B)</li> <li><a href="/w/index.php?title=KLRC1&action=edit&redlink=1" class="new" title="KLRC1 (page does not exist)">KLRC1</a>, <a href="/wiki/KLRC2" title="KLRC2">KLRC2</a>, <a href="/w/index.php?title=KLRC3&action=edit&redlink=1" class="new" title="KLRC3 (page does not exist)">KLRC3</a>, <a href="/wiki/KLRC4" title="KLRC4">KLRC4</a></li> <li><a href="/wiki/KLRD1" title="KLRD1">KLRD1</a></li> <li><a href="/w/index.php?title=KLRF1&action=edit&redlink=1" class="new" title="KLRF1 (page does not exist)">KLRF1</a> (CLEC5C)</li> <li><a href="/wiki/KLRG1" title="KLRG1">KLRG1</a> (CLEC15A), <a href="/w/index.php?title=KLRG2&action=edit&redlink=1" class="new" title="KLRG2 (page does not exist)">KLRG2</a> (CLEC15B)</li> <li><a href="/wiki/NKG2D" title="NKG2D">KLRK1</a></li></ul> <p>Additional proteins containing this domain include: </p> <ul><li><a href="/w/index.php?title=AGC1&action=edit&redlink=1" class="new" title="AGC1 (page does not exist)">AGC1</a>; <a href="/w/index.php?title=ATRNL1&action=edit&redlink=1" class="new" title="ATRNL1 (page does not exist)">ATRNL1</a></li> <li><a href="/wiki/BCAN" class="mw-redirect" title="BCAN">BCAN</a></li> <li><a href="/wiki/CD248" title="CD248">CD248</a>; <a href="/wiki/CD72" title="CD72">CD72</a>; <a href="/wiki/CD93" title="CD93">CD93</a>; <a href="/wiki/CHODL" title="CHODL">CHODL</a>; <a href="/w/index.php?title=CL-K1-Ia&action=edit&redlink=1" class="new" title="CL-K1-Ia (page does not exist)">CL-K1-Ia</a>; <a href="/w/index.php?title=CL-K1-Ib&action=edit&redlink=1" class="new" title="CL-K1-Ib (page does not exist)">CL-K1-Ib</a>; <a href="/w/index.php?title=CL-K1-Ic&action=edit&redlink=1" class="new" title="CL-K1-Ic (page does not exist)">CL-K1-Ic</a>; <a href="/w/index.php?title=CLECSF5&action=edit&redlink=1" class="new" title="CLECSF5 (page does not exist)">CLECSF5</a>; <a href="/wiki/COLEC10" class="mw-redirect" title="COLEC10">COLEC10</a>; <a href="/w/index.php?title=COLEC11&action=edit&redlink=1" class="new" title="COLEC11 (page does not exist)">COLEC11</a>; <a href="/wiki/COLEC12" class="mw-redirect" title="COLEC12">COLEC12</a>; <a href="/wiki/CSPG3" class="mw-redirect" title="CSPG3">CSPG3</a></li> <li><a href="/wiki/FCER2" class="mw-redirect" title="FCER2">FCER2</a>; <a href="/wiki/FREM1" title="FREM1">FREM1</a>; <a href="/w/index.php?title=HBXBP&action=edit&redlink=1" class="new" title="HBXBP (page does not exist)">HBXBP</a>;</li> <li><a href="/wiki/LAYN" class="mw-redirect" title="LAYN">LAYN</a>; <a href="/w/index.php?title=LOC348174&action=edit&redlink=1" class="new" title="LOC348174 (page does not exist)">LOC348174</a>; <a href="/w/index.php?title=LOC728276&action=edit&redlink=1" class="new" title="LOC728276 (page does not exist)">LOC728276</a></li> <li><a href="/wiki/MAFA" title="MAFA">MAFA</a>; <a href="/wiki/MBL2" class="mw-redirect" title="MBL2">MBL2</a>; <a href="/w/index.php?title=MGC34761&action=edit&redlink=1" class="new" title="MGC34761 (page does not exist)">MGC34761</a>; <a href="/wiki/MICL" class="mw-redirect" title="MICL">MICL</a>; <a href="/wiki/MRC1L1" class="mw-redirect" title="MRC1L1">MRC1L1</a></li> <li><a href="/wiki/OLR1" title="OLR1">OLR1</a></li> <li><a href="/w/index.php?title=Pancreatitis-associated_protein&action=edit&redlink=1" class="new" title="Pancreatitis-associated protein (page does not exist)">PAP</a>; <a href="/wiki/PKD1" class="mw-redirect" title="PKD1">PKD1</a>; <a href="/w/index.php?title=PKD1L2&action=edit&redlink=1" class="new" title="PKD1L2 (page does not exist)">PKD1L2</a>; <a href="/wiki/PLA2R1" title="PLA2R1">PLA2R1</a>; <a href="/wiki/PRG2" class="mw-redirect" title="PRG2">PRG2</a>; <a href="/w/index.php?title=PRG3&action=edit&redlink=1" class="new" title="PRG3 (page does not exist)">PRG3</a></li> <li><a href="/wiki/REG1A" title="REG1A">REG1A</a>; <a href="/wiki/REG1B" title="REG1B">REG1B</a>; <a href="/wiki/REG3A" title="REG3A">REG3A</a>; <a href="/wiki/REG3G" title="REG3G">REG3G</a>; <a href="/wiki/REG4" title="REG4">REG4</a></li> <li><a href="/wiki/SELE" class="mw-redirect" title="SELE">SELE</a>; <a href="/wiki/SELL" class="mw-redirect" title="SELL">SELL</a>; <a href="/wiki/SELP" class="mw-redirect" title="SELP">SELP</a>; <a href="/wiki/SFTPA1" class="mw-redirect" title="SFTPA1">SFTPA1</a>; <a href="/wiki/SFTPA2" class="mw-redirect" title="SFTPA2">SFTPA2</a>; <a href="/wiki/SFTPA2B" class="mw-redirect" title="SFTPA2B">SFTPA2B</a>; <a href="/wiki/SFTPD" class="mw-redirect" title="SFTPD">SFTPD</a>; <a href="/w/index.php?title=SRCL&action=edit&redlink=1" class="new" title="SRCL (page does not exist)">SRCL</a></li> <li><a href="/wiki/THBD" class="mw-redirect" title="THBD">THBD</a></li> <li><a href="/wiki/VCAN" class="mw-redirect" title="VCAN">VCAN</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=C-type_lectin&action=edit&section=2" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-pmid15049685-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid15049685_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFWalkerNagarYoungHirama2004" class="citation journal cs1">Walker JR, Nagar B, Young NM, Hirama T, Rini JM (April 2004). 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Biol</i>. <b>19</b> (9): R375–8. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2009CBio...19.R375C">2009CBio...19.R375C</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cub.2009.03.032">10.1016/j.cub.2009.03.032</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19439262">19439262</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:17409821">17409821</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Curr.+Biol.&rft.atitle=Necrosis%3A+C-type+lectins+sense+cell+death&rft.volume=19&rft.issue=9&rft.pages=R375-8&rft.date=2009-05&rft_id=info%3Adoi%2F10.1016%2Fj.cub.2009.03.032&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A17409821%23id-name%3DS2CID&rft_id=info%3Apmid%2F19439262&rft_id=info%3Abibcode%2F2009CBio...19.R375C&rft.aulast=Cambi&rft.aufirst=A&rft.au=Figdor%2C+C&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.cub.2009.03.032&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC-type+lectin" class="Z3988"></span></span> </li> <li id="cite_note-pmid8341801-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8341801_7-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDrickamer_K1993" class="citation journal cs1">Drickamer K (1993). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0079-6603%2808%2960870-3">"Evolution of Ca(2+)-dependent animal lectins"</a>. <i>Prog. 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A.; McMurray, J. L.; Mohammed, F.; Bicknell, R. (2019). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852297">"C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation"</a>. <i>FEBS Journal</i>. <b>286</b> (17): 3299–3332. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Ffebs.14985">10.1111/febs.14985</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852297">6852297</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/31287944">31287944</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=FEBS+Journal&rft.atitle=C-type+lectin+domain+group+14+proteins+in+vascular+biology%2C+cancer+and+inflammation.&rft.volume=286&rft.issue=17&rft.pages=3299-3332&rft.date=2019&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6852297%23id-name%3DPMC&rft_id=info%3Apmid%2F31287944&rft_id=info%3Adoi%2F10.1111%2Ffebs.14985&rft.aulast=Khan&rft.aufirst=K.+A.&rft.au=McMurray%2C+J.+L.&rft.au=Mohammed%2C+F.&rft.au=Bicknell%2C+R.&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6852297&rfr_id=info%3Asid%2Fen.wikipedia.org%3AC-type+lectin" class="Z3988"></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=NK+Cell+Lectin-Like+Receptors">NK+Cell+Lectin-Like+Receptors</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=C-type_lectin&action=edit&section=3" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://www.functionalglycomics.org/">Functional Glycomics Gateway</a>, a collaboration between the <a href="/wiki/Consortium_for_Functional_Glycomics" title="Consortium for Functional Glycomics">Consortium for Functional Glycomics</a> and <a href="/wiki/Nature_Publishing_Group" class="mw-redirect" title="Nature Publishing Group">Nature Publishing Group</a></li></ul> <div class="navbox-styles"><style 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.navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Protein:_lectins" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" 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abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Lectins" title="Template:Lectins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Lectins" title="Template talk:Lectins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Lectins" title="Special:EditPage/Template:Lectins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Protein:_lectins" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Protein</a>: <a href="/wiki/Lectin" title="Lectin">lectins</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Animal</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a class="mw-selflink selflink">C-type lectins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Asialoglycoprotein_receptor" title="Asialoglycoprotein receptor">Asialoglycoprotein receptor</a></li> <li><a href="/wiki/KLRD1" title="KLRD1">KLRD1</a></li> <li><a href="/wiki/Collectin" title="Collectin">Collectin</a> <ul><li><a href="/wiki/Mannan-binding_lectin" title="Mannan-binding lectin">Mannan-binding lectin</a></li></ul></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">Mannose receptor</a></li> <li><i><a href="/wiki/Proteochondroitin_sulfate" class="mw-redirect" title="Proteochondroitin sulfate">proteochondroitin sulfate</a></i> <ul><li><a href="/wiki/Aggrecan" title="Aggrecan">Aggrecan</a></li> <li><a href="/wiki/Versican" title="Versican">Versican</a></li> <li><a href="/wiki/Brevican" title="Brevican">Brevican</a></li> <li><a href="/wiki/Neurocan" title="Neurocan">Neurocan</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/SIGLEC" class="mw-redirect" title="SIGLEC">SIGLEC</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sialoadhesin" title="Sialoadhesin">Sialoadhesin</a></li> <li><a href="/wiki/CD22" title="CD22">CD22</a></li> <li><a href="/wiki/CD33" title="CD33">CD33</a></li> <li><a href="/wiki/Myelin-associated_glycoprotein" title="Myelin-associated glycoprotein">Myelin-associated glycoprotein</a></li> <li><a href="/wiki/SIGLEC5" title="SIGLEC5">SIGLEC5</a></li> <li><a href="/wiki/SIGLEC6" title="SIGLEC6">SIGLEC6</a></li> <li><a href="/wiki/SIGLEC7" title="SIGLEC7">SIGLEC7</a></li> <li><a href="/wiki/SIGLEC8" title="SIGLEC8">SIGLEC8</a></li> <li><a href="/wiki/SIGLEC9" title="SIGLEC9">SIGLEC9</a></li> <li><a href="/wiki/SIGLEC10" title="SIGLEC10">SIGLEC10</a></li> <li><a href="/wiki/SIGLEC12" class="mw-redirect" title="SIGLEC12">SIGLEC12</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calnexin" title="Calnexin">Calnexin</a></li> <li><a href="/wiki/Calreticulin" title="Calreticulin">Calreticulin</a></li> <li><a href="/wiki/Galectin" title="Galectin">Galectin</a></li> <li><a href="/wiki/N-Acetylglucosamine_receptor" title="N-Acetylglucosamine receptor">N-Acetylglucosamine receptor</a></li> <li><a href="/wiki/Selectin" title="Selectin">Selectin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Plant</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Toxalbumin" title="Toxalbumin">Toxalbumins</a> <ul><li><a href="/wiki/Abrin" title="Abrin">Abrin</a></li> <li><a href="/wiki/Ricin" title="Ricin">Ricin</a></li></ul></li> <li><a href="/wiki/Mitogen" title="Mitogen">Mitogens</a> <ul><li><a href="/wiki/Concanavalin_A" title="Concanavalin A">Concanavalin A</a></li> <li><a href="/wiki/Phytohaemagglutinin" title="Phytohaemagglutinin">Phytohaemagglutinin</a></li> <li><a href="/wiki/Pokeweed_mitogen" title="Pokeweed mitogen">Pokeweed mitogen</a></li></ul></li> <li><a href="/wiki/Legume_lectin" title="Legume lectin">Legume lectin</a></li> <li><a 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