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class="breadcrumb-link-text-wrap">Biopharmaceutical</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-current-title">Unlocking the Future of Medicine: Exploring Therapeutic Oligonucleotides</span></div></div></header><div class="site-inner"><div class="content-sidebar-wrap"><main class="content"><article class="post-17181 post type-post status-publish format-standard has-post-thumbnail category-biopharmaceutical tag-biopharmaceutical tag-columns-and-consumables tag-hplc tag-oligonucleotide entry" aria-label="Unlocking the Future of Medicine: Exploring Therapeutic Oligonucleotides"><header class="entry-header"><h1 class="entry-title">Unlocking the Future of Medicine: Exploring Therapeutic Oligonucleotides</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/analyteguru/tf-author/lizzie-gallagher/" title="Posts by Lizzie Gallagher" rel="author">Lizzie Gallagher, Market Development Manager, Pharma and BioPharma, Thermo Fisher Scientific</a> </span> <span class="post-info-date"> 03.05.2024 </span> </header><div class="entry-content"> <p><em>This is the fourth in a five-part BioPharma Blog Series.</em></p> <p>You may have noticed an increased mention of oligonucleotides. The reason for this surge in attention is quite remarkable. Therapeutic oligonucleotides have emerged as a rapidly expanding category of drugs, poised to revolutionize the standard of care for numerous diseases and pave the way for personalized medicine. As part of this blog, you will find our four most recent posters, which recently were presented at a U.S.-based conference in Texas.</p> <figure class="wp-block-image size-large"><img decoding="async" width="1024" height="576" src="https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/03/Blog-2048x1152-1-1024x576.jpg" alt="Oligonucleotide analysis" class="wp-image-17183" srcset="https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/03/Blog-2048x1152-1-1024x576.jpg 1024w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/03/Blog-2048x1152-1-300x169.jpg 300w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/03/Blog-2048x1152-1-768x432.jpg 768w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/03/Blog-2048x1152-1-1536x864.jpg 1536w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/03/Blog-2048x1152-1.jpg 2048w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure> <p>These posters detail how the most recent advances in analytical technology allow those working with oligonucleotides to:</p> <ul class="wp-block-list"> <li>Conquer the challenges related to controlling the immune response</li> <li>Enhance the stability of the therapeutic products</li> <li>Fine-tune the delivery system to effectively target the intended therapy site</li> </ul> <p>It’s worth noting that regulatory guidelines are continuously evolving due to the complexity of oligonucleotide molecules and the various modifications being applied to them. Therefore, accurate and robust analytical characterization is essential for the analysis of oligonucleotide therapeutics.</p> <p>To support your oligonucleotide workflow comprehensively, the Thermo Scientific portfolio offers an array of cutting-edge solutions:</p> <ul class="wp-block-list"> <li>DNAPac HPLC columns for precise analysis</li> <li>The Vanquish HPLC family for robust performance</li> <li>The Orbitrap Exploris mass spectrometer for accurate results</li> <li>The BioPharma Finder software to streamline your workflow</li> </ul> <h3 class="wp-block-heading" id="h-related-information"><strong>Related information</strong></h3> <p>Blog 1: <a href="https://www.thermofisher.com/blog/analyteguru/revolutionizing-host-cell-protein-detection-in-biopharma/" target="_blank" rel="noreferrer noopener">Revolutionizing Host Cell Protein Detection and mAb Analysis in Biopharmaceuticals</a><br>Blog 2: <a href="https://www.thermofisher.com/blog/analyteguru/poster-series-on-biopharma-column-chemistry/" target="_blank" rel="noreferrer noopener">Poster Series: A Journey into the World of Biopharma Column Chemistry</a><br>Blog 3: <a href="https://www.thermofisher.com/blog/analyteguru/take-a-step-closer-to-unlocking-full-potential-of-aav-gene-therapy-download-the-poster/" target="_blank" rel="noreferrer noopener">Take a Step Closer to Unlocking Full Potential of AAV Gene Therapy – Download the Poster</a><br>Blog 5: <a href="https://www.thermofisher.com/blog/analyteguru/unveiling-hidden-impurities-lc-hrms-for-biopharmaceutical-analysis/" target="_blank" rel="noreferrer noopener">Unveiling Hidden Impurities: LC-HRMS for Biopharmaceutical Analysis</a><br>Download our <a href="https://www.thermofisher.com/us/en/home/global/forms/industrial/unlocking-future-medicine.html?cid=E.23CMD.PB103.17953.01" target="_blank" rel="noreferrer noopener">conference posters</a> to see how we applied advanced analytical technology to achieve the best results for oligonucleotide analysis</p> <p>On LinkedIn? Visit our <a href="https://www.linkedin.com/showcase/chromatography-&-mass-spectrometry/posts/?feedView=all" target="_blank" rel="noreferrer noopener">LinkedIn page</a> #biopharmaceutical</p> </div></article><section class="author-box"><h4 class="author-box-title">Lizzie Gallagher</h4><div class="author-box-content" itemprop="description">Lizzie Gallagher is a market development manager for the pharma and biopharma market at Thermo Fisher Science, having spent a number of years in both industry, and sales and marketing. Lizzie has widespread experience with the challenges and trends of the biopharma and pharma market. </div></section><div class="adjacent-entry-pagination pagination"><div class="pagination-previous alignleft"><i class="fa fa-icon fa-chevron-left"></i> <a href="https://www.thermofisher.com/blog/analyteguru/analyzing-natural-gas-a-new-way-to-determine-alkanolamines/" rel="prev">Analyzing Natural Gas? A New Way to Determine Alkanolamines With Improved Separation Technology</a></div><div class="pagination-next alignright"><a href="https://www.thermofisher.com/blog/analyteguru/methylmercury-in-edible-fish-how-to-detect-critical-levels-in-cod-and-tuna/" rel="next">Methylmercury in Edible Fish: How to Detect Critical Levels in Cod and Tuna?</a> <i class="fa fa-icon fa-chevron-right"></i></div></div></main></div></div><footer class="site-footer"><div class="wrap"><div class="creds"><p class="footer-links"><a href="https://corporate.thermofisher.com/en/footer/privacy-statement.html" target="_blank" rel="noopener noreferrer">Privacy Statement</a><a href="https://corporate.thermofisher.com/en/footer/terms-and-conditions.html" target="_blank" rel="noopener noreferrer">Terms & Conditions</a><a href="/blog/locations/">Locations</a><a href="/blog/sitemap/">Sitemap</a></p><p>© 2024 <a href="https://www.thermofisher.com">Thermo Fisher Scientific</a>. 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