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href=\"/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%A2%D0%B0%D0%BA%D0%BC%D0%B8%D1%87%D0%B5%D1%9A%D0%B5_%D1%83_%D0%BF%D0%B8%D1%81%D0%B0%D1%9A%D1%83_%D1%87%D0%BB%D0%B0%D0%BD%D0%B0%D0%BA%D0%B0/%D0%A3_%D1%81%D0%B2%D0%B5%D1%82%D1%83_%D0%A4%D0%BB%D0%BE%D1%80%D0%B5_%D0%B8_%D0%A4%D0%B0%D1%83%D0%BD%D0%B5\" title=\"Википедија:Такмичење у писању чланака/У свету Флоре и Фауне\"\u003EФлоре и фауне\u003C/a\u003E\u003C/b\u003E.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\n\u003Cdiv class=\"noticebanner\"\u003E\u003Cdiv class=\"plainlinks\" style=\"background-color: #FBEBEA; border-radius:5px; margin-top:10px; position:relative; border: 1px solid #aaa; font-family: \u0026#39;Helvetica\u0026#39;, \u0026#39;Arial\u0026#39;, sans-serif; line-height: 18px; box-shadow: 0 1px 1px rgba( 0, 0, 0, 0.15 ); overflow:hidden;\"\u003E\u003Cdiv style=\"display:block; top:4px; width:100%; text-align:center;;\"\u003E\u003Cdiv style=\"color:#000085; 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class=\"noticebanner\"\u003E\u003Cdiv class=\"plainlinks\" style=\"background-color: #FBEBEA; border-radius:5px; margin-top:10px; position:relative; border: 1px solid #aaa; font-family: \u0026#39;Helvetica\u0026#39;, \u0026#39;Arial\u0026#39;, sans-serif; line-height: 18px; box-shadow: 0 1px 1px rgba( 0, 0, 0, 0.15 ); overflow:hidden;\"\u003E\u003Cdiv style=\"display:block; top:4px; width:100%; text-align:center;;\"\u003E\u003Cdiv style=\"color:#000085; font-size:25px; line-height:25px\"\u003E\u003Cdiv style=\"padding-left:50px;\"\u003E\u003C/div\u003E\u003C/div\u003E\u003Cdiv style=\"padding-top:2px; color:#444; font-size:1.15em; line-height:1.5;\"\u003E\u003Cdiv style=\"padding-left:8px; padding-right:8px;\"\u003EУчествујте у \u003Cb\u003E\u003Ca href=\"https://sr.wikiquote.org/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D1%86%D0%B8%D1%82%D0%B0%D1%82:%D0%9A%D0%B0%D0%BC%D0%BF%D0%B0%D1%9A%D0%B0_SheSaid_2024\" class=\"extiw\" title=\"q:Викицитат:Кампања SheSaid 2024\"\u003Eкампањи писања цитата значајних жена\u003C/a\u003E\u003C/b\u003E на Викицитату.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\n\u003Cdiv class=\"noticebanner\"\u003E\u003Cdiv class=\"plainlinks\" style=\"background-color: #FBEBEA; border-radius:5px; margin-top:10px; position:relative; border: 1px solid #aaa; font-family: \u0026#39;Helvetica\u0026#39;, \u0026#39;Arial\u0026#39;, sans-serif; line-height: 18px; box-shadow: 0 1px 1px rgba( 0, 0, 0, 0.15 ); overflow:hidden;\"\u003E\u003Cdiv style=\"display:block; top:4px; width:100%; text-align:center;;\"\u003E\u003Cdiv style=\"color:#000085; font-size:25px; line-height:25px\"\u003E\u003Cdiv style=\"padding-left:50px;\"\u003E\u003C/div\u003E\u003C/div\u003E\u003Cdiv style=\"padding-top:2px; color:#444; font-size:1.15em; line-height:1.5;\"\u003E\u003Cdiv style=\"padding-left:8px; padding-right:8px;\"\u003EПридружите се \u003Cb\u003E\u003Ca href=\"/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%90%D0%BA%D1%86%D0%B8%D1%98%D0%B0_%D0%BF%D1%80%D0%BE%D1%88%D0%B8%D1%80%D0%B8%D0%B2%D0%B0%D1%9A%D0%B0_%D0%BA%D0%BB%D0%B8%D1%86%D0%B0\" title=\"Википедија:Акција проширивања клица\"\u003Eакцији проширивања клица\u003C/a\u003E\u003C/b\u003E.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E";}}());</script></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Сајт"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Садржај" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Садржај</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">помери на страну</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">сакриј</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Почетак</div> </a> </li> <li id="toc-Opis" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Opis"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Opis</span> </div> </a> <ul id="toc-Opis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Prednosti" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Prednosti"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Prednosti</span> </div> </a> <ul id="toc-Prednosti-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Nedostaci" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Nedostaci"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Nedostaci</span> </div> </a> <ul id="toc-Nedostaci-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Vidi_još" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Vidi_još"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Vidi još</span> </div> </a> <ul id="toc-Vidi_još-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Literatura" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Literatura"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Literatura</span> </div> </a> <ul id="toc-Literatura-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Spoljašnje_veze" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Spoljašnje_veze"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Spoljašnje veze</span> </div> </a> <button aria-controls="toc-Spoljašnje_veze-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Садржај одељка Spoljašnje veze</span> </button> <ul id="toc-Spoljašnje_veze-sublist" class="vector-toc-list"> <li id="toc--{OPM}-_baza_podataka" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#-{OPM}-_baza_podataka"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>OPM baza podataka</span> </div> </a> <ul id="toc--{OPM}-_baza_podataka-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pregledi" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Pregledi"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2</span> <span>Pregledi</span> </div> </a> <ul id="toc-Pregledi-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Drugi_srodni_resursi" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Drugi_srodni_resursi"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.3</span> <span>Drugi srodni resursi</span> </div> </a> <ul id="toc-Drugi_srodni_resursi-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Садржај" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Прикажи/сакриј садржај" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Прикажи/сакриј садржај</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Baza podataka orijentacija proteina u membranama</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Чланак на другим језицима. 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البروتينات في الأغشية" data-language-autonym="العربية" data-language-local-name="арапски" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Orientations_of_Proteins_in_Membranes_database" title="Orientations of Proteins in Membranes database — енглески" lang="en" hreflang="en" data-title="Orientations of Proteins in Membranes database" data-language-autonym="English" data-language-local-name="енглески" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/OPM_(base_de_donn%C3%A9es)" title="OPM (base de données) — француски" lang="fr" hreflang="fr" data-title="OPM (base de données)" data-language-autonym="Français" data-language-local-name="француски" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Orientations_of_Proteins_in_Membranes" title="Orientations of Proteins in Membranes — галицијски" lang="gl" hreflang="gl" data-title="Orientations of Proteins in Membranes" data-language-autonym="Galego" data-language-local-name="галицијски" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/Orientations_of_Proteins_in_Membranes_database" title="Orientations of Proteins in Membranes database — јапански" lang="ja" hreflang="ja" data-title="Orientations of Proteins in Membranes database" data-language-autonym="日本語" data-language-local-name="јапански" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Baza_podataka_orijentacija_proteina_u_membranama" title="Baza podataka orijentacija proteina u membranama — српскохрватски" lang="sh" hreflang="sh" 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class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Алатке странице"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Изглед"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Изглед</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">помери на страну</button> <button 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srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/62/1h6h.png/300px-1h6h.png 1.5x, //upload.wikimedia.org/wikipedia/commons/6/62/1h6h.png 2x" data-file-width="386" data-file-height="461" /></a><figcaption><a href="/w/index.php?title=Periferni_protein&action=edit&redlink=1" class="new" title="Periferni protein (страница не постоји)">Periferni protein</a> iz OPM baze podataka (P40phox <a href="/wiki/PX_domen" title="PX domen">PX domen</a> NADPH oksidaze). Srednja ravan lipidnog dvosloja - srne tačke. Granica ugljenovodoničnog centralnog regiona - plave tačke (intracelularna strana). Slog lipidnih fosfata - žute tačke. </figcaption></figure> <p><b>Baza podataka orijentacija proteina u membranama (<a href="/wiki/%D0%95%D0%BD%D0%B3%D0%BB%D0%B5%D1%81%D0%BA%D0%B8_%D1%98%D0%B5%D0%B7%D0%B8%D0%BA" title="Енглески језик">engl.</a> <span lang="en"><i><i><span lang="en" title="енглески текст">Orientations of Proteins in Membranes</span></i></i></span>, OPM)</b> sadrži prostorne orijentacije proteinskih tri-dimenzionalnih struktura u odnosu na <a href="/wiki/Lipidni_dvosloj" title="Lipidni dvosloj">lipidni dvosloj</a>.<sup id="cite_ref-OPM-cite_1-0" class="reference"><a href="#cite_note-OPM-cite-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OPM1_2-0" class="reference"><a href="#cite_note-OPM1-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-peripheral_3-0" class="reference"><a href="#cite_note-peripheral-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Ova baza podatak je bila korišćena u eksperimentalnim i teoretskim studijama za membranu-vezanih proteina.<sup id="cite_ref-park-helms_4-0" class="reference"><a href="#cite_note-park-helms-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-marsh-jost-peggion_5-0" class="reference"><a href="#cite_note-marsh-jost-peggion-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pfb-2007_6-0" class="reference"><a href="#cite_note-pfb-2007-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-cyl-2006_7-0" class="reference"><a href="#cite_note-cyl-2006-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pbm-2006_8-0" class="reference"><a href="#cite_note-pbm-2006-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Opis">Opis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baza_podataka_orijentacija_proteina_u_membranama&veaction=edit&section=1" title="Уредите одељак „Opis”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Baza_podataka_orijentacija_proteina_u_membranama&action=edit&section=1" title="Уреди извор одељка: Opis"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Proteinske strukture su uzet iz <a href="/w/index.php?title=Baza_podataka_proteina&action=edit&redlink=1" class="new" title="Baza podataka proteina (страница не постоји)">baze podataka proteina</a>. Pozicije proteina u hidrofobnoj ploči su izračunate koristeći <a href="/w/index.php?title=Implicitna_solvatacija&action=edit&redlink=1" class="new" title="Implicitna solvatacija (страница не постоји)">model implicitne solvatacije</a>. </p><p>OPM sadrži strukturnu klasifikaciju za membranu-vezanih proteina u familije i superfamilije (baziranu na <a href="/wiki/Strukturna_klasifikacija_proteina" title="Strukturna klasifikacija proteina">SCOP</a> klasifikacije), <a href="/w/index.php?title=Membranska_topologija&action=edit&redlink=1" class="new" title="Membranska topologija (страница не постоји)">membransku topologiju</a>, i tip odredišta <a href="/wiki/Biolo%C5%A1ka_membrana" title="Biološka membrana">membrane</a> za svaki protein. Svi fajlovi sa proteinskim koordinatama sa izračunatim membranskim granicama su slobodno dostupni. </p><p>Ovaj sajt omogućava vizuelizaciju proteinskih struktura sa ravnima membranskih granica koristeći <a href="/wiki/Jmol" title="Jmol">Jmol</a>, <a href="/w/index.php?title=MDL_Chime&action=edit&redlink=1" class="new" title="MDL Chime (страница не постоји)">MDL Chime</a> i WebMol. </p> <div class="mw-heading mw-heading2"><h2 id="Prednosti">Prednosti</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baza_podataka_orijentacija_proteina_u_membranama&veaction=edit&section=2" title="Уредите одељак „Prednosti”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Baza_podataka_orijentacija_proteina_u_membranama&action=edit&section=2" title="Уреди извор одељка: Prednosti"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Ova baza podataka sadrži prostorne pozicije <a href="/wiki/Transmembranski_protein" title="Transmembranski protein">transmembranskih</a> i <a href="/w/index.php?title=Periferni_membranski_proteini&action=edit&redlink=1" class="new" title="Periferni membranski proteini (страница не постоји)">perifernih membranskih</a> proteina u lipidnom dvosloju, zajedno sa bazom podataka transmembranskih proteina<sup id="cite_ref-pdbtm_9-0" class="reference"><a href="#cite_note-pdbtm-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> koja uvrštava samo transmembranske proteine. Izračunate pozicije proteina su bile kompajlirane sa relevantnim eksperimentalnim podacima za 24 transmembranska i 53 periferno membranska proteina<sup id="cite_ref-peripheral_3-1" class="reference"><a href="#cite_note-peripheral-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> uključujući <a href="/w/index.php?title=Mesto-usmereno_spinsko_obele%C5%BEavanje&action=edit&redlink=1" class="new" title="Mesto-usmereno spinsko obeležavanje (страница не постоји)">mesto-usmereno spinsko obeležavanje</a>,<sup id="cite_ref-Malmberg_10-0" class="reference"><a href="#cite_note-Malmberg-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> hemijsko obeležavanje, merenja membranskih vezivnih afiniteta proteinskih <a href="/w/index.php?title=Mutageneza&action=edit&redlink=1" class="new" title="Mutageneza (страница не постоји)">mutanata</a>,<sup id="cite_ref-Spencer_11-0" class="reference"><a href="#cite_note-Spencer-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Fluorescencija" title="Fluorescencija">fluorescentnu</a> spektroskopiju,<sup id="cite_ref-Lathrop_12-0" class="reference"><a href="#cite_note-Lathrop-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> <a href="/wiki/NMR_spektroskopija" class="mw-redirect" title="NMR spektroskopija">NMR spektroskopiju</a> rastvora ili čvrstog-stanja ,<sup id="cite_ref-Kuta_13-0" class="reference"><a href="#cite_note-Kuta-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> ATR <a href="/w/index.php?title=FTIR&action=edit&redlink=1" class="new" title="FTIR (страница не постоји)">FTIR spektroskopiju</a>,<sup id="cite_ref-Tatulian_14-0" class="reference"><a href="#cite_note-Tatulian-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> i difrakcione studije proteina u lipidnim slojevima X-zracima ili neutronima<sup id="cite_ref-Hristova_15-0" class="reference"><a href="#cite_note-Hristova-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Nedostaci">Nedostaci</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baza_podataka_orijentacija_proteina_u_membranama&veaction=edit&section=3" title="Уредите одељак „Nedostaci”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Baza_podataka_orijentacija_proteina_u_membranama&action=edit&section=3" title="Уреди извор одељка: Nedostaci"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>OPM kolekcija <a href="/w/index.php?title=Periferni_membranski_protein&action=edit&redlink=1" class="new" title="Periferni membranski protein (страница не постоји)">perifernih membranskih proteina</a> nije kompletna. Ova baza podataka verovatno sadrži manje od 50% PDB perifernih proteina, zato što za-membranu-učvršćujući elementi <a href="/w/index.php?title=Periferni_protein&action=edit&redlink=1" class="new" title="Periferni protein (страница не постоји)">perifernih proteina</a> (<a href="/wiki/%D0%90%D0%BC%D1%84%D0%B8%D1%84%D0%B8%D0%BB" class="mw-redirect" title="Амфифил">amfifilni</a> <a href="/wiki/%D0%90%D0%BB%D1%84%D0%B0_%D1%85%D0%B5%D0%BB%D0%B8%D0%BA%D1%81" title="Алфа хеликс">alfa heliksi</a>, izloženi nonpolarni ostaci, ili <a href="/wiki/Lipid-vezani_proteini" title="Lipid-vezani proteini">lipid-vezani proteini</a>) nedostaju ili su neuređeni u eksperimentalnim proteinskim strukturama, i stoga mod protein-membranske veze ne može biti računski predviđen<sup id="cite_ref-peripheral_3-2" class="reference"><a href="#cite_note-peripheral-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Vidi_još"><span id="Vidi_jo.C5.A1"></span>Vidi još</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baza_podataka_orijentacija_proteina_u_membranama&veaction=edit&section=4" title="Уредите одељак „Vidi još”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Baza_podataka_orijentacija_proteina_u_membranama&action=edit&section=4" title="Уреди извор одељка: Vidi još"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Transmembranski_protein" title="Transmembranski protein">Transmembranski protein</a></li> <li><a href="/wiki/Integralni_membranski_protein" title="Integralni membranski protein">Integralni membranski protein</a></li> <li><a href="/w/index.php?title=Periferni_membranski_protein&action=edit&redlink=1" class="new" title="Periferni membranski protein (страница не постоји)">Periferni membranski protein</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Literatura">Literatura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baza_podataka_orijentacija_proteina_u_membranama&veaction=edit&section=5" title="Уредите одељак „Literatura”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Baza_podataka_orijentacija_proteina_u_membranama&action=edit&section=5" title="Уреди извор одељка: Literatura"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r28440201">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-OPM-cite-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-OPM-cite_1-0">^</a></b></span> <span class="reference-text"><cite class="citation journal">Lomize, Mikhail A.; Lomize, Andrei L; Pogozheva, Irina D.; Mosberg, Henry I. (2006). <a rel="nofollow" class="external text" href="http://opm.phar.umich.edu/OPM.pdf">„OPM: Orientations of Proteins in Membranes database”</a> <span style="font-size:85%;">(PDF)</span>. <i>Bioinformatics</i>. <b>22</b> (5): 623—625. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/16397007">16397007</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fbioinformatics%2Fbtk023">10.1093/bioinformatics/btk023</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3ABaza+podataka+orijentacija+proteina+u+membranama&rft.atitle=OPM%3A+Orientations+of+Proteins+in+Membranes+database&rft.au=Lomize%2C+Andrei+L&rft.au=Mosberg%2C+Henry+I.&rft.au=Pogozheva%2C+Irina+D.&rft.aufirst=Mikhail+A.&rft.aulast=Lomize&rft.date=2006&rft.genre=article&rft.issue=5&rft.jtitle=Bioinformatics&rft.pages=623-625&rft.volume=22&rft_id=http%3A%2F%2Fopm.phar.umich.edu%2FOPM.pdf&rft_id=info%3Adoi%2F10.1093%2Fbioinformatics%2Fbtk023&rft_id=info%3Apmid%2F16397007&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-OPM1-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-OPM1_2-0">^</a></b></span> <span class="reference-text"><cite class="citation journal">Lomize, Andrei L; Pogozheva, Irina D.; Lomize, Mikhail A.; Mosberg, Henry I. 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(2001). „Changes in Ca<sup>2+</sup> affinity upon activation of <i>Agkistrodon piscivorus piscivorus</i> phospholipase A<sub>2</sub>”. <i>Biochemistry</i>. <b>40</b> (11): 3264—72. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/11258945">11258945</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Fbi001901n">10.1021/bi001901n</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3ABaza+podataka+orijentacija+proteina+u+membranama&rft.atitle=Changes+in+Ca%3Csup%3E2%2B%3C%2Fsup%3E+affinity+upon+activation+of+Agkistrodon+piscivorus+piscivorus+phospholipase+A%3Csub%3E2%3C%2Fsub%3E&rft.au=Biltonen%2C+Rodney+L.&rft.au=Gadd%2C+Martha&rft.au=Rule%2C+Gordon+S.&rft.aufirst=Brian&rft.aulast=Lathrop&rft.date=2001&rft.genre=article&rft.issue=11&rft.jtitle=Biochemistry&rft.pages=3264-72&rft.volume=40&rft_id=info%3Adoi%2F10.1021%2Fbi001901n&rft_id=info%3Apmid%2F11258945&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-Kuta-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-Kuta_13-0">^</a></b></span> <span class="reference-text"><cite class="citation journal">Kutateladze, Tatiana; Overduin, Michael (2001). „Structural Mechanism of Endosome Docking by the FYVE Domain”. <i>Science</i>. <b>291</b> (5509): 1793—6. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/11230696">11230696</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.291.5509.1793">10.1126/science.291.5509.1793</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3ABaza+podataka+orijentacija+proteina+u+membranama&rft.atitle=Structural+Mechanism+of+Endosome+Docking+by+the+FYVE+Domain&rft.au=Overduin%2C+Michael&rft.aufirst=Tatiana&rft.aulast=Kutateladze&rft.date=2001&rft.genre=article&rft.issue=5509&rft.jtitle=Science&rft.pages=1793-6&rft.volume=291&rft_id=info%3Adoi%2F10.1126%2Fscience.291.5509.1793&rft_id=info%3Apmid%2F11230696&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-Tatulian-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-Tatulian_14-0">^</a></b></span> <span class="reference-text"><cite class="citation journal">Tatulian, Suren A.; Qin, Shan; Pande, Abhay H.; He, Xiaomei (2005). „Positioning membrane proteins by novel protein engineering and biophysical approaches”. <i>J Mol Biol</i>. <b>351</b> (5): 939—947. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/16055150">16055150</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jmb.2005.06.080">10.1016/j.jmb.2005.06.080</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3ABaza+podataka+orijentacija+proteina+u+membranama&rft.atitle=Positioning+membrane+proteins+by+novel+protein+engineering+and+biophysical+approaches&rft.au=He%2C+Xiaomei&rft.au=Pande%2C+Abhay+H.&rft.au=Qin%2C+Shan&rft.aufirst=Suren+A.&rft.aulast=Tatulian&rft.date=2005&rft.genre=article&rft.issue=5&rft.jtitle=J+Mol+Biol&rft.pages=939-947&rft.volume=351&rft_id=info%3Adoi%2F10.1016%2Fj.jmb.2005.06.080&rft_id=info%3Apmid%2F16055150&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-Hristova-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-Hristova_15-0">^</a></b></span> <span class="reference-text"><cite class="citation journal">Hristova, Kalina; Wimley, William C.; Mishra, Vinod K.; Anantharamiah, G.M.; Segrest, Jere P.; White, Stephen H. (1999). „An amphipathic α-helix at a membrane interface: a structural study using a novel X-ray diffraction method”. <i>J Mol Biol</i>. <b>290</b> (1): 99—117. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/10388560">10388560</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fjmbi.1999.2840">10.1006/jmbi.1999.2840</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3ABaza+podataka+orijentacija+proteina+u+membranama&rft.atitle=An+amphipathic+%CE%B1-helix+at+a+membrane+interface%3A+a+structural+study+using+a+novel+X-ray+diffraction+method&rft.au=Anantharamiah%2C+G.M.&rft.au=Mishra%2C+Vinod+K.&rft.au=Segrest%2C+Jere+P.&rft.au=White%2C+Stephen+H.&rft.au=Wimley%2C+William+C.&rft.aufirst=Kalina&rft.aulast=Hristova&rft.date=1999&rft.genre=article&rft.issue=1&rft.jtitle=J+Mol+Biol&rft.pages=99-117&rft.volume=290&rft_id=info%3Adoi%2F10.1006%2Fjmbi.1999.2840&rft_id=info%3Apmid%2F10388560&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Spoljašnje_veze"><span id="Spolja.C5.A1nje_veze"></span>Spoljašnje veze</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a 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