CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Hatice Gunes - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="Y671oEkeZIKY6OSusl1y1yNwKYe/YSixR0+EmTNeU5IJ9kEagmczO8Lu9aHKOgfh/eWrZymAX96GohyywvmAOw==" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-77f7b87cb1583fc59aa8f94756ebfe913345937eb932042b4077563bebb5fb4b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-9e8218e1301001388038e3fc3427ed00d079a4760ff7745d1ec1b2d59103170a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="author" content="hatice gunes" /> <meta name="description" content="Hatice Gunes: 1 Following, 23 Research papers. Research interests: Turbulence, Sustainable Energy, and Philology." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = '9387f500ddcbb8d05c67bef28a2fe0334f1aafb8'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15268,"monthly_visitors":"113 million","monthly_visitor_count":113758192,"monthly_visitor_count_in_millions":113,"user_count":277668215,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1732980754000); window.Aedu.timeDifference = new Date().getTime() - 1732980754000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-bdb9e8c097f01e611f2fc5e2f1a9dc599beede975e2ae5629983543a1726e947.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-3e572e3b706c3ed2ec5b2c1cb44a411fadc81f62a97963cb7bd9c327a0a9d5f2.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-2e8d3f30eaaddd1debd6ce4630b3453b23a23c91ac7c823ddf8822879835b029.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/HaticeGunes6" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://medium.com/@academia">Blog</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-ae3d0ee232cd83d11499343688b0160a3c7db15e95cb2d0844cae78d49ea53f1.js" defer="defer"></script><script>Aedu.rankings = { showPaperRankingsLink: false } $viewedUser = Aedu.User.set_viewed( {"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6","photo":"/images/s65_no_pic.png","has_photo":false,"is_analytics_public":false,"interests":[{"id":2802,"name":"Turbulence","url":"https://www.academia.edu/Documents/in/Turbulence"},{"id":15284,"name":"Sustainable Energy","url":"https://www.academia.edu/Documents/in/Sustainable_Energy"},{"id":97,"name":"Philology","url":"https://www.academia.edu/Documents/in/Philology"},{"id":2298,"name":"Computational Fluid Dynamics","url":"https://www.academia.edu/Documents/in/Computational_Fluid_Dynamics"},{"id":10875,"name":"Aerodynamics","url":"https://www.academia.edu/Documents/in/Aerodynamics"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/HaticeGunes6","location":"/HaticeGunes6","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/HaticeGunes6","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-10385cbf-3a94-421c-b78a-b827facf76cb"></div> <div id="ProfileCheckPaperUpdate-react-component-10385cbf-3a94-421c-b78a-b827facf76cb"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Hatice Gunes</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Hatice" data-follow-user-id="262028830" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="262028830"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">0</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">1</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="262028830" href="https://www.academia.edu/Documents/in/Turbulence"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/HaticeGunes6","location":"/HaticeGunes6","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/HaticeGunes6","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Turbulence"]}" data-trace="false" data-dom-id="Pill-react-component-1f0d2386-e749-4fac-88c5-0b009571f939"></div> <div id="Pill-react-component-1f0d2386-e749-4fac-88c5-0b009571f939"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="262028830" href="https://www.academia.edu/Documents/in/Sustainable_Energy"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Sustainable Energy"]}" data-trace="false" data-dom-id="Pill-react-component-09a73367-0ef4-486a-b23f-b5af59580f0b"></div> <div id="Pill-react-component-09a73367-0ef4-486a-b23f-b5af59580f0b"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="262028830" href="https://www.academia.edu/Documents/in/Philology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Philology"]}" data-trace="false" data-dom-id="Pill-react-component-097f5205-9304-46c0-9cfb-15196d8c22e9"></div> <div id="Pill-react-component-097f5205-9304-46c0-9cfb-15196d8c22e9"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="262028830" href="https://www.academia.edu/Documents/in/Computational_Fluid_Dynamics"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Computational Fluid Dynamics"]}" data-trace="false" data-dom-id="Pill-react-component-e074e4ab-bf7b-492b-99e9-179c4836641f"></div> <div id="Pill-react-component-e074e4ab-bf7b-492b-99e9-179c4836641f"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="262028830" href="https://www.academia.edu/Documents/in/Aerodynamics"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Aerodynamics"]}" data-trace="false" data-dom-id="Pill-react-component-00f2a2c7-5cd2-4a25-b54d-4555d5f53cd7"></div> <div id="Pill-react-component-00f2a2c7-5cd2-4a25-b54d-4555d5f53cd7"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Hatice Gunes</h3></div><div class="js-work-strip profile--work_container" data-work-id="98686168"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686168/Cytotoxic_Activities_of_Certain_Medicinal_Plants_on_Different_Cancer_Cell_Lines"><img alt="Research paper thumbnail of Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines" class="work-thumbnail" src="https://attachments.academia-assets.com/99969924/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686168/Cytotoxic_Activities_of_Certain_Medicinal_Plants_on_Different_Cancer_Cell_Lines">Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines</a></div><div class="wp-workCard_item"><span>Turkish Journal of Pharmaceutical Sciences</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4ec777e470d24a2b7b340ee2a7bf1221" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969924,"asset_id":98686168,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969924/download_file?st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686168"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686168"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686168; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686168]").text(description); $(".js-view-count[data-work-id=98686168]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686168; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686168']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686168, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4ec777e470d24a2b7b340ee2a7bf1221" } } $('.js-work-strip[data-work-id=98686168]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686168,"title":"Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines","translated_title":"","metadata":{"publisher":"Galenos Yayinevi","grobid_abstract":"Son yıllarda kanserin önlenmesi ve tedavisi için, farklı sınıfta fitokimyasal içerikleri ve daha az yan etkileri nedeniyle bitkilerin kullanımı oldukça önem kazanmaktadır. Bu çalışmada, Türkiye'nin Kars ilinden toplanan dört farklı tıbbi bitki türünün altı farklı kanser hücre hattı ve bir normal hücre hattı üzerindeki sitotoksik etkileri incelenmiştir. Gereç ve Yöntemler: Sitotoksik aktivite MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-dipenyltetrazolium bromide] yöntemiyle belirlenirken, apoptotik hücre ölümü akış sitometri ve kaspaz-3 analizleriyle tespit edilmiştir. Bulgular: Artemisia absinthium yaprak özütü A-549, CCC-221, K-562, MCF-7, PC-3 hücre hatları üzerinde anlamlı sitotoksik etki (≥%70) gösterirken, tohum özütü ise CCC-221, K-562, MCF-7, PC-3 hücreleri üzerinde anlamlı sitotoksik etki (≥%70) göstermiştir. Normal hücre hattı Beas-2B hücresine kıyasla, seçici sitotoksik aktivite yaprak özütüyle A-549 ve K-562 hücreleri üzerinde gözlenirken, tohum özütüyle K-562, MCF-7 ve PC-3 hücreleri üzerinde gözlenmiştir. Her iki özütün sitotoksisite seviyesi düşük konsantrasyonlarda zaman ve doza bağlı olarak değişmektedir. İlave olarak, Plantago major bitki özütüyle A-549 hücreleri üzerinde seçici sitotoksisite (%78) elde edilmiştir. Hyoscyamus niger ve Amaranthus retrosa özütlerinin sitotoksisite aktivitesinin %10 ve %30 olduğu gözlenmiştir. Sonuç: A. absinthium özütleri ve P. major tohum özütü gelecek çalışmalarda bazı kanser hücrelerinin sitotoksisitesi için tedavi edici ilaç geliştirilmesi potansiyeline sahiptirler.","publication_name":"Turkish Journal of Pharmaceutical Sciences","grobid_abstract_attachment_id":99969924},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686168/Cytotoxic_Activities_of_Certain_Medicinal_Plants_on_Different_Cancer_Cell_Lines","translated_internal_url":"","created_at":"2023-03-17T06:03:31.788-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969924,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969924/thumbnails/1.jpg","file_name":"TJPS-14-3.pdf","download_url":"https://www.academia.edu/attachments/99969924/download_file?st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cytotoxic_Activities_of_Certain_Medicina.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969924/TJPS-14-3-libre.pdf?1679062085=\u0026response-content-disposition=attachment%3B+filename%3DCytotoxic_Activities_of_Certain_Medicina.pdf\u0026Expires=1732984353\u0026Signature=K2bV599y~Ida6Nhb-jMQth3UpYO863PN1SgmnTiQF0LxLcXIhAkjsApm96Fn1jv1S3hF7UuTELS1mgtG2zic0zvoBc~GbtKgcbbmet-6c4sjctqeUyvCOCwFUpu~Bq42u3OEyxlWRAF6L9vtxsSLb9aZRxszt35ANSlGlgZH27BZDcKDv4YMLpXo8tDNDy4ihghJpvZMeZljZUP~2PUfEhRUwOwnn0Ef7JdQPS30LPJBSHgdE-6HeZ5h2nJr621czzdzhFf-EVUBkVCKGaQeuHk-eD9VwfeKdmy6omFbOumPJj5N6GOw9qu4HXGPtdSsI5imIkyhfc2fffO8zvb6lg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cytotoxic_Activities_of_Certain_Medicinal_Plants_on_Different_Cancer_Cell_Lines","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969924,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969924/thumbnails/1.jpg","file_name":"TJPS-14-3.pdf","download_url":"https://www.academia.edu/attachments/99969924/download_file?st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cytotoxic_Activities_of_Certain_Medicina.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969924/TJPS-14-3-libre.pdf?1679062085=\u0026response-content-disposition=attachment%3B+filename%3DCytotoxic_Activities_of_Certain_Medicina.pdf\u0026Expires=1732984353\u0026Signature=K2bV599y~Ida6Nhb-jMQth3UpYO863PN1SgmnTiQF0LxLcXIhAkjsApm96Fn1jv1S3hF7UuTELS1mgtG2zic0zvoBc~GbtKgcbbmet-6c4sjctqeUyvCOCwFUpu~Bq42u3OEyxlWRAF6L9vtxsSLb9aZRxszt35ANSlGlgZH27BZDcKDv4YMLpXo8tDNDy4ihghJpvZMeZljZUP~2PUfEhRUwOwnn0Ef7JdQPS30LPJBSHgdE-6HeZ5h2nJr621czzdzhFf-EVUBkVCKGaQeuHk-eD9VwfeKdmy6omFbOumPJj5N6GOw9qu4HXGPtdSsI5imIkyhfc2fffO8zvb6lg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":15019,"name":"Medicinal Plants","url":"https://www.academia.edu/Documents/in/Medicinal_Plants"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":41720,"name":"Human","url":"https://www.academia.edu/Documents/in/Human"},{"id":112576,"name":"Cell Death","url":"https://www.academia.edu/Documents/in/Cell_Death"},{"id":169415,"name":"Article","url":"https://www.academia.edu/Documents/in/Article"},{"id":247477,"name":"Caspase","url":"https://www.academia.edu/Documents/in/Caspase"},{"id":369262,"name":"Amaranthus","url":"https://www.academia.edu/Documents/in/Amaranthus"},{"id":468970,"name":"Drug effect","url":"https://www.academia.edu/Documents/in/Drug_effect"},{"id":546352,"name":"Controlled Study","url":"https://www.academia.edu/Documents/in/Controlled_Study"},{"id":553283,"name":"Cancer cells","url":"https://www.academia.edu/Documents/in/Cancer_cells"},{"id":584594,"name":"Drug Efficacy","url":"https://www.academia.edu/Documents/in/Drug_Efficacy"},{"id":1134083,"name":"Medicinal Plant","url":"https://www.academia.edu/Documents/in/Medicinal_Plant"},{"id":1316597,"name":"Human Cell","url":"https://www.academia.edu/Documents/in/Human_Cell"},{"id":2034545,"name":"Hyoscyamus","url":"https://www.academia.edu/Documents/in/Hyoscyamus"},{"id":2254256,"name":"Artemisia Absinthium","url":"https://www.academia.edu/Documents/in/Artemisia_Absinthium"},{"id":2487926,"name":"drug response","url":"https://www.academia.edu/Documents/in/drug_response"},{"id":3887567,"name":"Antineoplastic activity","url":"https://www.academia.edu/Documents/in/Antineoplastic_activity"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686167"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686167/Solanum_lycopersicum_Yaprak_Ekstrakt%C4%B1n%C4%B1n_Farkl%C4%B1_%C4%B0nsan_H%C3%BCcre_Hatlar%C4%B1ndaki_Sitotoksik_Potansiyeli"><img alt="Research paper thumbnail of Solanum lycopersicum Yaprak Ekstraktının Farklı İnsan Hücre Hatlarındaki Sitotoksik Potansiyeli" class="work-thumbnail" src="https://attachments.academia-assets.com/99969905/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686167/Solanum_lycopersicum_Yaprak_Ekstrakt%C4%B1n%C4%B1n_Farkl%C4%B1_%C4%B0nsan_H%C3%BCcre_Hatlar%C4%B1ndaki_Sitotoksik_Potansiyeli">Solanum lycopersicum Yaprak Ekstraktının Farklı İnsan Hücre Hatlarındaki Sitotoksik Potansiyeli</a></div><div class="wp-workCard_item"><span>Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5d1e4b9af3fe88ead37db11685ceb0e9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969905,"asset_id":98686167,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969905/download_file?st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686167"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686167"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686167; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686167]").text(description); $(".js-view-count[data-work-id=98686167]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686167; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686167']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686167, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5d1e4b9af3fe88ead37db11685ceb0e9" } } $('.js-work-strip[data-work-id=98686167]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686167,"title":"Solanum lycopersicum Yaprak Ekstraktının Farklı İnsan Hücre Hatlarındaki Sitotoksik Potansiyeli","translated_title":"","metadata":{"publisher":"Bilecik Seyh Edebali Universitesi Fen Bilimleri Dergisi","grobid_abstract":"Bitkiler geleneksel olarak çeşitli hastalıklara karşı çare olarak kullanılmaktadır. Bu çalışmada Solanum lycopersicum yapraklarının etanol ekstraktının potansiyel sitotoksik etkileri A549, HeLa, PC-3, MCF-7 ve HEK293 hücre hatlarında araştırılmıştır. Hücre canlılığının belirlenmesi için MTT deneyi kullanılmıştır. Ekstarakt ile muamele edilen A549 ve HeLa hücrelerinde apoptoz ve kaspaz-3 aktivitesi araştırılmıştır. 31.25 µg mL-1 konsantrasyonda, bu ekstrakt, 72 saatte test edilen kanser hücrelerinde % 50'den fazla sitotoksisiteye neden olmuştur. S. lycopersicum ekstraktının A549 ve HeLa hücrelerinde apoptozu indüklediği belirlenmiştir. Ayrıca, S. lycopersicum yapraklarının ekstresi aynı hücrelerde önemli kaspaz-3 aktivitesine neden olmuştur. Bu bulgular temel olarak antikanser ajanların gelişimi için S. lycopersicum yaprak ekstraktının kullanımı ile ilgili araştırmalara katkıda bulunabilir.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi","grobid_abstract_attachment_id":99969905},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686167/Solanum_lycopersicum_Yaprak_Ekstrakt%C4%B1n%C4%B1n_Farkl%C4%B1_%C4%B0nsan_H%C3%BCcre_Hatlar%C4%B1ndaki_Sitotoksik_Potansiyeli","translated_internal_url":"","created_at":"2023-03-17T06:03:31.670-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969905/thumbnails/1.jpg","file_name":"949948.pdf","download_url":"https://www.academia.edu/attachments/99969905/download_file?st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Solanum_lycopersicum_Yaprak_Ekstraktinin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969905/949948-libre.pdf?1679062085=\u0026response-content-disposition=attachment%3B+filename%3DSolanum_lycopersicum_Yaprak_Ekstraktinin.pdf\u0026Expires=1732984353\u0026Signature=ak78TI2YTArgvEBBRnTUdOpfSChN-p5WrXuptobHQfAE7sycI8YKiX8VSVyW8lQfv8of6wL-i8xLySYVo4wMmzEZy5mFgjsReuzm5svYkaETGW9U14m7EfvQ4yaZsOp7~p45vP0HK-Vm~KydGljixkwSLH0veHlQV0V8deCLQVp9BaUuUGtAj~3Bc0w1wQyGH3xwJFIbJ5QCZA1Tg1rNRDz8BQnhzGrl0kbhnzWEcXhlg4NOxfgggbgcTNrgFSTRwH1uwrDjLls4V0mEIkxeQjgYyDCkTvb2Qe0B66mHz83zXlcSntDjfjf2H7bDv~4anctuqmzMNH7vnhFoZfpC5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Solanum_lycopersicum_Yaprak_Ekstraktının_Farklı_İnsan_Hücre_Hatlarındaki_Sitotoksik_Potansiyeli","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969905/thumbnails/1.jpg","file_name":"949948.pdf","download_url":"https://www.academia.edu/attachments/99969905/download_file?st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Solanum_lycopersicum_Yaprak_Ekstraktinin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969905/949948-libre.pdf?1679062085=\u0026response-content-disposition=attachment%3B+filename%3DSolanum_lycopersicum_Yaprak_Ekstraktinin.pdf\u0026Expires=1732984353\u0026Signature=ak78TI2YTArgvEBBRnTUdOpfSChN-p5WrXuptobHQfAE7sycI8YKiX8VSVyW8lQfv8of6wL-i8xLySYVo4wMmzEZy5mFgjsReuzm5svYkaETGW9U14m7EfvQ4yaZsOp7~p45vP0HK-Vm~KydGljixkwSLH0veHlQV0V8deCLQVp9BaUuUGtAj~3Bc0w1wQyGH3xwJFIbJ5QCZA1Tg1rNRDz8BQnhzGrl0kbhnzWEcXhlg4NOxfgggbgcTNrgFSTRwH1uwrDjLls4V0mEIkxeQjgYyDCkTvb2Qe0B66mHz83zXlcSntDjfjf2H7bDv~4anctuqmzMNH7vnhFoZfpC5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":474180,"name":"Solanum","url":"https://www.academia.edu/Documents/in/Solanum"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686166"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686166/Determination_of_the_effects_of_biomaterials_on_human_peripheral_blood_mononuclear_cells_PBMC_"><img alt="Research paper thumbnail of Determination of the effects of biomaterials on human peripheral blood mononuclear cells (PBMC)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686166/Determination_of_the_effects_of_biomaterials_on_human_peripheral_blood_mononuclear_cells_PBMC_">Determination of the effects of biomaterials on human peripheral blood mononuclear cells (PBMC)</a></div><div class="wp-workCard_item"><span>Technology and Health Care</span><span>, Sep 19, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT End-stage liver disease accounts for over 30,000 deaths annually in the United States. O...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT End-stage liver disease accounts for over 30,000 deaths annually in the United States. Orthotopic liver transplantation is the only clinically proven treatment for patients with end-stage liver failure. A limitation of this therapy is a shortage of donor ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686166"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686166"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686166; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686166]").text(description); $(".js-view-count[data-work-id=98686166]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686166; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686166']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686166, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686166]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686166,"title":"Determination of the effects of biomaterials on human peripheral blood mononuclear cells (PBMC)","translated_title":"","metadata":{"abstract":"ABSTRACT End-stage liver disease accounts for over 30,000 deaths annually in the United States. Orthotopic liver transplantation is the only clinically proven treatment for patients with end-stage liver failure. A limitation of this therapy is a shortage of donor ...","publisher":"IOS Press","publication_date":{"day":19,"month":9,"year":2002,"errors":{}},"publication_name":"Technology and Health Care"},"translated_abstract":"ABSTRACT End-stage liver disease accounts for over 30,000 deaths annually in the United States. Orthotopic liver transplantation is the only clinically proven treatment for patients with end-stage liver failure. A limitation of this therapy is a shortage of donor ...","internal_url":"https://www.academia.edu/98686166/Determination_of_the_effects_of_biomaterials_on_human_peripheral_blood_mononuclear_cells_PBMC_","translated_internal_url":"","created_at":"2023-03-17T06:03:31.498-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Determination_of_the_effects_of_biomaterials_on_human_peripheral_blood_mononuclear_cells_PBMC_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":2698,"name":"Biomaterials","url":"https://www.academia.edu/Documents/in/Biomaterials"},{"id":4594,"name":"Carbon Dioxide","url":"https://www.academia.edu/Documents/in/Carbon_Dioxide"},{"id":57799,"name":"Biocompatibility","url":"https://www.academia.edu/Documents/in/Biocompatibility"},{"id":849784,"name":"Health Care Technology","url":"https://www.academia.edu/Documents/in/Health_Care_Technology"},{"id":1198580,"name":"Mononuclear Cells","url":"https://www.academia.edu/Documents/in/Mononuclear_Cells"},{"id":1309704,"name":"Protein Determination","url":"https://www.academia.edu/Documents/in/Protein_Determination"},{"id":3833419,"name":"Peripheral blood","url":"https://www.academia.edu/Documents/in/Peripheral_blood"}],"urls":[{"id":29866548,"url":"https://dl.acm.org/doi/10.5555/781744.781782"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686165"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686165/Antibacterial_and_Antitumor_Activity_of_Crude_Methanolic_Extracts_from_Various_Macrofungi_Species"><img alt="Research paper thumbnail of Antibacterial and Antitumor Activity of Crude Methanolic Extracts from Various Macrofungi Species" class="work-thumbnail" src="https://attachments.academia-assets.com/99969858/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686165/Antibacterial_and_Antitumor_Activity_of_Crude_Methanolic_Extracts_from_Various_Macrofungi_Species">Antibacterial and Antitumor Activity of Crude Methanolic Extracts from Various Macrofungi Species</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mushrooms are considered to be an important natural resource for the investigation of new compoun...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mushrooms are considered to be an important natural resource for the investigation of new compounds with antimicrobial, anti-tumor orimmunomodulatory effects because of their secondary metabolites and degrading enzymes. In this study, antibacterial and antitumorpotential of Cantharellus cibarius, Clitocybe geotropa, Gyromitra esculenta, Lactarius delicious, Melanoleuca exscissa, Ramaria flava,Sarcosphaera crassa, Morchella sp., Stereum hirsutum and Trametes versicolor mushrooms collected from Mugla region have beeninvestigated with disc diffusion method and MTT assay, respectively. Among all mushroom extracts, M. exscissa extract showed the highestantimicrobial effect on E. coli (22 mm, 80 µg/disc inhibition zone). It was observed that 8 out of 16 mushroom extracts did not show anyeffect on all test microorganisms, the others formed up to 9 mm inhibition zone in diameters. In addition, a total of 16 mushroom extracts(400 µg/ml) were tested on 5 different cancer cell lines. It was de...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="212764924367221722252fda50894b84" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969858,"asset_id":98686165,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969858/download_file?st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686165"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686165"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686165; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686165]").text(description); $(".js-view-count[data-work-id=98686165]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686165; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686165']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686165, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "212764924367221722252fda50894b84" } } $('.js-work-strip[data-work-id=98686165]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686165,"title":"Antibacterial and Antitumor Activity of Crude Methanolic Extracts from Various Macrofungi Species","translated_title":"","metadata":{"abstract":"Mushrooms are considered to be an important natural resource for the investigation of new compounds with antimicrobial, anti-tumor orimmunomodulatory effects because of their secondary metabolites and degrading enzymes. In this study, antibacterial and antitumorpotential of Cantharellus cibarius, Clitocybe geotropa, Gyromitra esculenta, Lactarius delicious, Melanoleuca exscissa, Ramaria flava,Sarcosphaera crassa, Morchella sp., Stereum hirsutum and Trametes versicolor mushrooms collected from Mugla region have beeninvestigated with disc diffusion method and MTT assay, respectively. Among all mushroom extracts, M. exscissa extract showed the highestantimicrobial effect on E. coli (22 mm, 80 µg/disc inhibition zone). It was observed that 8 out of 16 mushroom extracts did not show anyeffect on all test microorganisms, the others formed up to 9 mm inhibition zone in diameters. In addition, a total of 16 mushroom extracts(400 µg/ml) were tested on 5 different cancer cell lines. It was de...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"Mushrooms are considered to be an important natural resource for the investigation of new compounds with antimicrobial, anti-tumor orimmunomodulatory effects because of their secondary metabolites and degrading enzymes. In this study, antibacterial and antitumorpotential of Cantharellus cibarius, Clitocybe geotropa, Gyromitra esculenta, Lactarius delicious, Melanoleuca exscissa, Ramaria flava,Sarcosphaera crassa, Morchella sp., Stereum hirsutum and Trametes versicolor mushrooms collected from Mugla region have beeninvestigated with disc diffusion method and MTT assay, respectively. Among all mushroom extracts, M. exscissa extract showed the highestantimicrobial effect on E. coli (22 mm, 80 µg/disc inhibition zone). It was observed that 8 out of 16 mushroom extracts did not show anyeffect on all test microorganisms, the others formed up to 9 mm inhibition zone in diameters. In addition, a total of 16 mushroom extracts(400 µg/ml) were tested on 5 different cancer cell lines. It was de...","internal_url":"https://www.academia.edu/98686165/Antibacterial_and_Antitumor_Activity_of_Crude_Methanolic_Extracts_from_Various_Macrofungi_Species","translated_internal_url":"","created_at":"2023-03-17T06:03:31.339-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969858,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969858/thumbnails/1.jpg","file_name":"257.pdf","download_url":"https://www.academia.edu/attachments/99969858/download_file?st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Antibacterial_and_Antitumor_Activity_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969858/257-libre.pdf?1679062087=\u0026response-content-disposition=attachment%3B+filename%3DAntibacterial_and_Antitumor_Activity_of.pdf\u0026Expires=1732984353\u0026Signature=ERRyBhMaBDoq2Z8rbc9MKoVZGUCNP1NG3Epxa6yy0dr9MF2h5dYtACCkrAB3DQzWd~C6p0ggV8R9t7IcA9DFnXqsUGtfp6slAX8Dtr~uii8HutLxeB55qG9O5OjLN0sQzt6CnqHCs7xrBWwXnDew2PQXCK2YfhTaKyIpPdN9olUieAbAwif0rd8QsLahbwpDMQSntYV8Q5wa-l-XyBcRQQpnM7czBuF8BDHYHOVkegrEm9kbin854KSqbXME7oNkNErivaow7OgT7pNxCBIzDDfr6QLQ3YFlD9AFy4WvkAZk92rgA5oXCnGkM1lSVm0VN5dP~TJBEiSGDroi8kd~hQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Antibacterial_and_Antitumor_Activity_of_Crude_Methanolic_Extracts_from_Various_Macrofungi_Species","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969858,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969858/thumbnails/1.jpg","file_name":"257.pdf","download_url":"https://www.academia.edu/attachments/99969858/download_file?st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Antibacterial_and_Antitumor_Activity_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969858/257-libre.pdf?1679062087=\u0026response-content-disposition=attachment%3B+filename%3DAntibacterial_and_Antitumor_Activity_of.pdf\u0026Expires=1732984353\u0026Signature=ERRyBhMaBDoq2Z8rbc9MKoVZGUCNP1NG3Epxa6yy0dr9MF2h5dYtACCkrAB3DQzWd~C6p0ggV8R9t7IcA9DFnXqsUGtfp6slAX8Dtr~uii8HutLxeB55qG9O5OjLN0sQzt6CnqHCs7xrBWwXnDew2PQXCK2YfhTaKyIpPdN9olUieAbAwif0rd8QsLahbwpDMQSntYV8Q5wa-l-XyBcRQQpnM7czBuF8BDHYHOVkegrEm9kbin854KSqbXME7oNkNErivaow7OgT7pNxCBIzDDfr6QLQ3YFlD9AFy4WvkAZk92rgA5oXCnGkM1lSVm0VN5dP~TJBEiSGDroi8kd~hQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":94562,"name":"Mushroom","url":"https://www.academia.edu/Documents/in/Mushroom"},{"id":220036,"name":"Antimicrobial","url":"https://www.academia.edu/Documents/in/Antimicrobial"},{"id":3287348,"name":"biology sciences","url":"https://www.academia.edu/Documents/in/biology_sciences-1"}],"urls":[{"id":29866547,"url":"http://bibad.gen.tr/index.php/bibad/article/download/258/257"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686164"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686164/Anticancer_effect_of_the_fruit_and_seed_extracts_of_Momordica_charantia_L_Cucurbitaceae_on_human_cancer_cell_lines"><img alt="Research paper thumbnail of Anticancer effect of the fruit and seed extracts of Momordica charantia L. (Cucurbitaceae) on human cancer cell lines" class="work-thumbnail" src="https://attachments.academia-assets.com/99969855/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686164/Anticancer_effect_of_the_fruit_and_seed_extracts_of_Momordica_charantia_L_Cucurbitaceae_on_human_cancer_cell_lines">Anticancer effect of the fruit and seed extracts of Momordica charantia L. (Cucurbitaceae) on human cancer cell lines</a></div><div class="wp-workCard_item"><span>Tropical Journal of Pharmaceutical Research</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose: To investigate anticancer effects of Momordica charantia L. (M. charantia) fruit and see...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose: To investigate anticancer effects of Momordica charantia L. (M. charantia) fruit and seed extracts on some cancer cell lines. Methods: Human cancer cell lines, including lung cancer (A549), breast cancer (MCF-7), chronic myeloid leukemia (K562) and T cell leukemia (Jurkat) were incubated with the extracts (0 - 0.8 mg/mL) for 72 h. The cytotoxic effects of the extracts were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5- dipenyltetrazolium bromide (MTT) assay. A549 and MCF-7 cells were treated with the ethanol fruit extract (FE) for 24 h and stained with propidium iodide (PI) for the analysis of cell cycle arrest using flow cytometry. Annexin V-FITC/PI staining along with flow cytometry analysis and caspase-3 assays were carried out to determine the apoptosis of the cells treated with FE extract for 24 h. Vascular endothelial growth factor (VEGF) secretion of the cells exposed to FE extract for 1 h was determined using enzyme-linked immunosorbent assay (ELISA). Cell invas...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="af9fec81167fffea0500020d67b60104" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969855,"asset_id":98686164,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969855/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686164"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686164"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686164; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686164]").text(description); $(".js-view-count[data-work-id=98686164]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686164; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686164']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686164, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "af9fec81167fffea0500020d67b60104" } } $('.js-work-strip[data-work-id=98686164]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686164,"title":"Anticancer effect of the fruit and seed extracts of Momordica charantia L. (Cucurbitaceae) on human cancer cell lines","translated_title":"","metadata":{"abstract":"Purpose: To investigate anticancer effects of Momordica charantia L. (M. charantia) fruit and seed extracts on some cancer cell lines. Methods: Human cancer cell lines, including lung cancer (A549), breast cancer (MCF-7), chronic myeloid leukemia (K562) and T cell leukemia (Jurkat) were incubated with the extracts (0 - 0.8 mg/mL) for 72 h. The cytotoxic effects of the extracts were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5- dipenyltetrazolium bromide (MTT) assay. A549 and MCF-7 cells were treated with the ethanol fruit extract (FE) for 24 h and stained with propidium iodide (PI) for the analysis of cell cycle arrest using flow cytometry. Annexin V-FITC/PI staining along with flow cytometry analysis and caspase-3 assays were carried out to determine the apoptosis of the cells treated with FE extract for 24 h. Vascular endothelial growth factor (VEGF) secretion of the cells exposed to FE extract for 1 h was determined using enzyme-linked immunosorbent assay (ELISA). Cell invas...","publisher":"African Journals Online (AJOL)","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Tropical Journal of Pharmaceutical Research"},"translated_abstract":"Purpose: To investigate anticancer effects of Momordica charantia L. (M. charantia) fruit and seed extracts on some cancer cell lines. Methods: Human cancer cell lines, including lung cancer (A549), breast cancer (MCF-7), chronic myeloid leukemia (K562) and T cell leukemia (Jurkat) were incubated with the extracts (0 - 0.8 mg/mL) for 72 h. The cytotoxic effects of the extracts were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5- dipenyltetrazolium bromide (MTT) assay. A549 and MCF-7 cells were treated with the ethanol fruit extract (FE) for 24 h and stained with propidium iodide (PI) for the analysis of cell cycle arrest using flow cytometry. Annexin V-FITC/PI staining along with flow cytometry analysis and caspase-3 assays were carried out to determine the apoptosis of the cells treated with FE extract for 24 h. Vascular endothelial growth factor (VEGF) secretion of the cells exposed to FE extract for 1 h was determined using enzyme-linked immunosorbent assay (ELISA). Cell invas...","internal_url":"https://www.academia.edu/98686164/Anticancer_effect_of_the_fruit_and_seed_extracts_of_Momordica_charantia_L_Cucurbitaceae_on_human_cancer_cell_lines","translated_internal_url":"","created_at":"2023-03-17T06:03:31.155-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969855,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969855/thumbnails/1.jpg","file_name":"197849.pdf","download_url":"https://www.academia.edu/attachments/99969855/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Anticancer_effect_of_the_fruit_and_seed.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969855/197849-libre.pdf?1679062084=\u0026response-content-disposition=attachment%3B+filename%3DAnticancer_effect_of_the_fruit_and_seed.pdf\u0026Expires=1732984354\u0026Signature=PxSx5ujBpTtLGnI2LhE56cV~zB~y9JADg~xodZeRCyfk1f~eiHJofHPibgPkOIq4cBbgFzBn3lP~7HOX7b07hv5X8o-OCEl7cjbRcCoOk1pwx79dd1R74Bj3rj5T9yboY972FDGhIvQrG0IdJk1~Cc4GE8NTxjayMhTCKCnES6BBhtkUPLZ4gaUHAIhZd2VvpbaVnym5s7-OV7yLX7zlayZCPzebe5zEx~l0wdF4B0zJV2UKlX6aMu4TzTSWTcJc0PA-gB6I4AvhxIUYI3HsKn8GDt8~83OjA2cmmX9iSFqFgTxhrJ9OU7XEMUizdBBjcA4BuHuI7fZz4D1kQLtD0A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Anticancer_effect_of_the_fruit_and_seed_extracts_of_Momordica_charantia_L_Cucurbitaceae_on_human_cancer_cell_lines","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969855,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969855/thumbnails/1.jpg","file_name":"197849.pdf","download_url":"https://www.academia.edu/attachments/99969855/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Anticancer_effect_of_the_fruit_and_seed.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969855/197849-libre.pdf?1679062084=\u0026response-content-disposition=attachment%3B+filename%3DAnticancer_effect_of_the_fruit_and_seed.pdf\u0026Expires=1732984354\u0026Signature=PxSx5ujBpTtLGnI2LhE56cV~zB~y9JADg~xodZeRCyfk1f~eiHJofHPibgPkOIq4cBbgFzBn3lP~7HOX7b07hv5X8o-OCEl7cjbRcCoOk1pwx79dd1R74Bj3rj5T9yboY972FDGhIvQrG0IdJk1~Cc4GE8NTxjayMhTCKCnES6BBhtkUPLZ4gaUHAIhZd2VvpbaVnym5s7-OV7yLX7zlayZCPzebe5zEx~l0wdF4B0zJV2UKlX6aMu4TzTSWTcJc0PA-gB6I4AvhxIUYI3HsKn8GDt8~83OjA2cmmX9iSFqFgTxhrJ9OU7XEMUizdBBjcA4BuHuI7fZz4D1kQLtD0A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":768729,"name":"Momordica","url":"https://www.academia.edu/Documents/in/Momordica"},{"id":1335154,"name":"Propidium Iodide","url":"https://www.academia.edu/Documents/in/Propidium_Iodide"},{"id":2272583,"name":"MTT assay","url":"https://www.academia.edu/Documents/in/MTT_assay"}],"urls":[{"id":29866546,"url":"https://www.ajol.info/index.php/tjpr/article/download/209844/197849"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686163"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686163/The_Anticancer_and_Anti_inflammatory_Effects_of_Centaurea_solstitialis_Extract_on_Human_Cancer_Cell_Lines"><img alt="Research paper thumbnail of The Anticancer and Anti-inflammatory Effects of Centaurea solstitialis Extract on Human Cancer Cell Lines" class="work-thumbnail" src="https://attachments.academia-assets.com/99969907/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686163/The_Anticancer_and_Anti_inflammatory_Effects_of_Centaurea_solstitialis_Extract_on_Human_Cancer_Cell_Lines">The Anticancer and Anti-inflammatory Effects of Centaurea solstitialis Extract on Human Cancer Cell Lines</a></div><div class="wp-workCard_item"><span>Turkish Journal of Pharmaceutical Sciences</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fe8d91bce9dff025efab71d10f872153" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969907,"asset_id":98686163,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969907/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686163"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686163"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686163; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686163]").text(description); $(".js-view-count[data-work-id=98686163]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686163; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686163']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686163, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fe8d91bce9dff025efab71d10f872153" } } $('.js-work-strip[data-work-id=98686163]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686163,"title":"The Anticancer and Anti-inflammatory Effects of Centaurea solstitialis Extract on Human Cancer Cell Lines","translated_title":"","metadata":{"publisher":"Galenos Yayinevi","grobid_abstract":"Bitkilerden elde edilen doğal ürünler, kanser dahil çeşitli hastalıkların tedavisinde uzun yıllardır kullanılmaktadır. Centaurea solstitialis subsp. solstitialis'in Türk geleneksel tıbbında yeri olduğu bilinmektedir. Bu araştırma, Muğla ilinden toplanan C. solstitialis'in çiçekli kısımlarından elde edilen etanolik özütün in vitro biyolojik etkilerini belirleyen ilk çalışmadır. Gereç ve Yöntemler: Özütün Daudi, A549 ve HeLa kanser hücrelerine ve normal BEAS-2B hücre hattına karşı sitotoksik etkisi MTT (3-(4,5dimetiltiyazol-2-il)-2,5-dipeniltetrazolyum bromür) testi ile belirlendi. Apoptotik hücre ölümü akış sitometri analizi ve kaspaz-3 aktivite deneyleriyle araştırıldı. Özüt ile muamele edilen hücreler tarafından üretilen anjiyojenik faktör [vasküler endotel büyüme faktörü (VEGF)] salınımı ve sitokinlerden interlökin (IL)-lα, IL-6 ve tümör nekroz faktör (TNF)-α'nın salınımı enzim bağlı immünosorbent deneyi testleriyle ölçüldü. Bulgular: Bitki özütü kullanılan tüm kanser hücre hatlarına karşı sitotoksik etki gösterirken, özüte karşı en duyarlı hücrelerin 63.18 µg/mL and 69.27 µg/mL olan IC 50 değerleri ile sırasıyla HeLa ve Daudi hücreleri olduğu gözlendi. Seçici sitotoksisite HeLa ve normal BEAS-2B hücre hatları arasında tespit edildi. Bitki özütü S ve G2 fazlarında hücre döngüsü arrestine yol açtı. Buna ilave olarak, HeLa ve A549 hücrelerinde apoptotik hücre ölümü kaydedildi. Ayrıca bitki özütü A549 hücrelerinin VEGF salgılamasında anlamlı bir düşüşe yol açarken, A549 ile Daudi hücrelerinin IL-lα, IL-6 ve TNF-α salgılamasında önemli değişime neden oldu. Sonuç: Bu bulgular kanser tedavisi ve sitokin salgısının modülasyonunda gerekli olan doğal ilaçların geliştirilmesi için C. solstitialis'in çiçekli kısımlarının potansiyel bir kaynak olabileceğini göstermektedir. Anahtar kelimeler: Centaurea solstitialis, kanser hücre hatları, anti-kanser, anti-inflamatuar Objectives: Natural products originating from plants have been used for many years in the treatment of various diseases, including cancer. Centaurea solstitialis subsp. solstitialis is used in Turkish folk medicine. This study was the first to determine the in vitro biological effects of ethanolic extract from the flowering parts of C. solstitialis L. subsp. solstitialis collected from Muğla Province. Materials and Methods: The cytotoxic effect was evaluated against Daudi, A549, and HeLa cancer cells and one normal BEAS-2B cell line using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-dipenyltetrazolium bromide) assay. Flow cytometric analysis and the caspase-3 activity assay were performed to detect apoptotic cell death. Angiogenic factor [vascular endothelial growth factor (VEGF)] secretion and the release of interleukin (IL)-1α, IL-6, and tumor necrosis factor (TNF)-α by cells treated with the extract were measured using enzyme-linked immunosorbent assay. Results: The extract exhibited cytotoxic effects against all the cancer cell lines used but HeLa and Daudi were the most sensitive cells, with IC 50 values of 63.18 µg/mL and 69.27 µg/mL, respectively. Selective cytotoxicity was observed between the HeLa and normal BEAS-2B cell lines. The extract arrested the cell cycle at the S and G2 phases. In addition, apoptotic cell death was detected in HeLa and A549 cells. Moreover, the plant extract caused a significant decrease in VEGF secretion in A549 cells and a fluctuation in IL-1α, IL-6, and TNF-α secretion in A549 and Daudi cells. Conclusion: These observations suggest that the flowering parts of C. solstitialis may be a potential source in the development of natural drugs for the treatment of cancer and modulation of cytokine secretion.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"Turkish Journal of Pharmaceutical Sciences","grobid_abstract_attachment_id":99969907},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686163/The_Anticancer_and_Anti_inflammatory_Effects_of_Centaurea_solstitialis_Extract_on_Human_Cancer_Cell_Lines","translated_internal_url":"","created_at":"2023-03-17T06:03:31.035-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969907,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969907/thumbnails/1.jpg","file_name":"TJPS-16-273-En.pdf","download_url":"https://www.academia.edu/attachments/99969907/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Anticancer_and_Anti_inflammatory_Eff.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969907/TJPS-16-273-En-libre.pdf?1679062089=\u0026response-content-disposition=attachment%3B+filename%3DThe_Anticancer_and_Anti_inflammatory_Eff.pdf\u0026Expires=1732984354\u0026Signature=HelQ~xMwP~j~tOOIoSy9vX0PFmXJHeXvtIJx68~bgABrF2VDuIFyqMWE5ZRfBijBrF7~klVJkZe1NnbMCDFNtQbNRHc0YjdrcYkbDUEzt8CsN~stQgU~nSBAApCIeoHWGaupjd7Xy6n7HhEi5fMqCwGuz5NLpZxKfWI6OnG0lV3DUvCt6G0u3~diOiZpZgIaHTj8IrU7a2uBX7rlXvDIGQ19RS49IsK2wbvD8YHo4IKlWhP8lP6WufkRh2XJ0MBvRLt1ymh~FvUTbDRKZ7cKBdKkaRbZQ2tx9Q2YSCOAA9zfvJM725y7T3aRb~l1rqWEKHuPC~maghnwJPhPaiP8GA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Anticancer_and_Anti_inflammatory_Effects_of_Centaurea_solstitialis_Extract_on_Human_Cancer_Cell_Lines","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969907,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969907/thumbnails/1.jpg","file_name":"TJPS-16-273-En.pdf","download_url":"https://www.academia.edu/attachments/99969907/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Anticancer_and_Anti_inflammatory_Eff.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969907/TJPS-16-273-En-libre.pdf?1679062089=\u0026response-content-disposition=attachment%3B+filename%3DThe_Anticancer_and_Anti_inflammatory_Eff.pdf\u0026Expires=1732984354\u0026Signature=HelQ~xMwP~j~tOOIoSy9vX0PFmXJHeXvtIJx68~bgABrF2VDuIFyqMWE5ZRfBijBrF7~klVJkZe1NnbMCDFNtQbNRHc0YjdrcYkbDUEzt8CsN~stQgU~nSBAApCIeoHWGaupjd7Xy6n7HhEi5fMqCwGuz5NLpZxKfWI6OnG0lV3DUvCt6G0u3~diOiZpZgIaHTj8IrU7a2uBX7rlXvDIGQ19RS49IsK2wbvD8YHo4IKlWhP8lP6WufkRh2XJ0MBvRLt1ymh~FvUTbDRKZ7cKBdKkaRbZQ2tx9Q2YSCOAA9zfvJM725y7T3aRb~l1rqWEKHuPC~maghnwJPhPaiP8GA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37782,"name":"Cell Culture","url":"https://www.academia.edu/Documents/in/Cell_Culture"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":608958,"name":"HeLa","url":"https://www.academia.edu/Documents/in/HeLa"},{"id":1490737,"name":"Secretion","url":"https://www.academia.edu/Documents/in/Secretion"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686162"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686162/Bioactivities_of_cry_gene_positive_Bacillus_thuringiensis_Berliner_Bacillales_Bacillaceae_strains_on_Ephestia_kuehniella_Zeller_1879_and_Plodia_interpunctella_H%C3%BCbner_1813_Lepidoptera_Pyralidae_"><img alt="Research paper thumbnail of Bioactivities of cry gene positive Bacillus thuringiensis (Berliner) (Bacillales: Bacillaceae) strains on Ephestia kuehniella Zeller, 1879 and Plodia interpunctella (Hübner, 1813) (Lepidoptera: Pyralidae)" class="work-thumbnail" src="https://attachments.academia-assets.com/99969906/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686162/Bioactivities_of_cry_gene_positive_Bacillus_thuringiensis_Berliner_Bacillales_Bacillaceae_strains_on_Ephestia_kuehniella_Zeller_1879_and_Plodia_interpunctella_H%C3%BCbner_1813_Lepidoptera_Pyralidae_">Bioactivities of cry gene positive Bacillus thuringiensis (Berliner) (Bacillales: Bacillaceae) strains on Ephestia kuehniella Zeller, 1879 and Plodia interpunctella (Hübner, 1813) (Lepidoptera: Pyralidae)</a></div><div class="wp-workCard_item"><span>Turkish Journal of Entomology</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6b00d760fdedf9d44104746ae005363c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969906,"asset_id":98686162,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969906/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686162"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686162"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686162; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686162]").text(description); $(".js-view-count[data-work-id=98686162]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686162; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686162']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686162, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6b00d760fdedf9d44104746ae005363c" } } $('.js-work-strip[data-work-id=98686162]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686162,"title":"Bioactivities of cry gene positive Bacillus thuringiensis (Berliner) (Bacillales: Bacillaceae) strains on Ephestia kuehniella Zeller, 1879 and Plodia interpunctella (Hübner, 1813) (Lepidoptera: Pyralidae)","translated_title":"","metadata":{"publisher":"Turkish Journal of Entomology","grobid_abstract":"Bioactivities of cry gene positive Bacillus thuringiensis (Berliner) (Bacillales: Bacillaceae) strains on Ephestia kuehniella Zeller, 1879 and Plodia interpunctella (Hübner, 1813) (Lepidoptera: Pyralidae) 1,2 cry gene pozitif Bacillus thuringiensis (Berliner) (Bacillales: Bacillaceae) izolatlarının","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Turkish Journal of Entomology","grobid_abstract_attachment_id":99969906},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686162/Bioactivities_of_cry_gene_positive_Bacillus_thuringiensis_Berliner_Bacillales_Bacillaceae_strains_on_Ephestia_kuehniella_Zeller_1879_and_Plodia_interpunctella_H%C3%BCbner_1813_Lepidoptera_Pyralidae_","translated_internal_url":"","created_at":"2023-03-17T06:03:30.916-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969906/thumbnails/1.jpg","file_name":"269962.pdf","download_url":"https://www.academia.edu/attachments/99969906/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bioactivities_of_cry_gene_positive_Bacil.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969906/269962-libre.pdf?1679062096=\u0026response-content-disposition=attachment%3B+filename%3DBioactivities_of_cry_gene_positive_Bacil.pdf\u0026Expires=1732984354\u0026Signature=Aq3IsWgYlOdi70Ei5LX~TRb8A0Vz-H~y~YNFcSxEbdaqLTTcNdLDvsmGJ4~UVbQKGFvgIOW~qBEzrh77ojU8f0qeCzPmdAaUEXAadCcU6WLphjnxJXLhgUfXLoeMaq6N0gVoMlQIB0EJBtRnCXCQiLj9mcVpst3SYvHocSB9o47TF2UoYzIs8ykR7nUREXaUjjet2WeNJPEHF8mxoBGaEDWHCJ0BLDktxu7fqUewpkc3ze0j8IqJCmdV6~Nj6YZmuttRRSBG59C2Bsg4GhPT6jPj4YubZDDHYnFyrey6vRq7gImoOaQzb~0JcXYffU9qMiHjU6IWZVNjZ03~IkYwig__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Bioactivities_of_cry_gene_positive_Bacillus_thuringiensis_Berliner_Bacillales_Bacillaceae_strains_on_Ephestia_kuehniella_Zeller_1879_and_Plodia_interpunctella_Hübner_1813_Lepidoptera_Pyralidae_","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969906/thumbnails/1.jpg","file_name":"269962.pdf","download_url":"https://www.academia.edu/attachments/99969906/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bioactivities_of_cry_gene_positive_Bacil.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969906/269962-libre.pdf?1679062096=\u0026response-content-disposition=attachment%3B+filename%3DBioactivities_of_cry_gene_positive_Bacil.pdf\u0026Expires=1732984354\u0026Signature=Aq3IsWgYlOdi70Ei5LX~TRb8A0Vz-H~y~YNFcSxEbdaqLTTcNdLDvsmGJ4~UVbQKGFvgIOW~qBEzrh77ojU8f0qeCzPmdAaUEXAadCcU6WLphjnxJXLhgUfXLoeMaq6N0gVoMlQIB0EJBtRnCXCQiLj9mcVpst3SYvHocSB9o47TF2UoYzIs8ykR7nUREXaUjjet2WeNJPEHF8mxoBGaEDWHCJ0BLDktxu7fqUewpkc3ze0j8IqJCmdV6~Nj6YZmuttRRSBG59C2Bsg4GhPT6jPj4YubZDDHYnFyrey6vRq7gImoOaQzb~0JcXYffU9qMiHjU6IWZVNjZ03~IkYwig__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":67768,"name":"Bacillus thuringiensis","url":"https://www.academia.edu/Documents/in/Bacillus_thuringiensis"},{"id":406914,"name":"Biopesticide","url":"https://www.academia.edu/Documents/in/Biopesticide"},{"id":1006629,"name":"Pyralidae","url":"https://www.academia.edu/Documents/in/Pyralidae"},{"id":3399686,"name":"plodia interpunctella","url":"https://www.academia.edu/Documents/in/plodia_interpunctella"},{"id":3586817,"name":"Bacillaceae","url":"https://www.academia.edu/Documents/in/Bacillaceae"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686161"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686161/Parasporins_as_a_natural_anti_cancer_protein"><img alt="Research paper thumbnail of Parasporins as a natural anti-cancer protein" class="work-thumbnail" src="https://attachments.academia-assets.com/99969902/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686161/Parasporins_as_a_natural_anti_cancer_protein">Parasporins as a natural anti-cancer protein</a></div><div class="wp-workCard_item"><span>ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="027e80d6a7804da2ad486e907e91a01c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969902,"asset_id":98686161,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969902/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686161"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686161"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686161; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686161]").text(description); $(".js-view-count[data-work-id=98686161]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686161; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686161']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686161, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "027e80d6a7804da2ad486e907e91a01c" } } $('.js-work-strip[data-work-id=98686161]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686161,"title":"Parasporins as a natural anti-cancer protein","translated_title":"","metadata":{"publisher":"Anadolu Universitesi Bilim ve Teknoloji Dergisi C : Yasam Bilimleri ve Biyoteknoloji","grobid_abstract":"Bacillus thuringiensis doğada geniş yayılım gösteren, gram pozitif ve spor oluşturan bir bakteridir. Sporulasyon evresinde, sporlarla birlikte birçok böcek çeşidine karşı insektisit etki gösteren kristal proteinleri de üretir. İnsektisidal kristal proteinler Cry ve Cyt proteinler olup; aktivitelerini duyarlı böceklerin orta barsak membranlarında bulunan reseptöre bağlanarak gösterirler. Bu reseptör bağlantılı özgül aktivitelerinden dolayı zirai mücadelede önemlidirler. Daha sonraları, insektisit olanlara göre doğada daha geniş dağılım gösteren insektisit olmayan kristal proteinler üzerindeki çalışmalar yeni bir protein sınıfı olan parasporinleri ortaya çıkarmıştır. Parasporinler ayrıcalıklı olarak kanser hücrelerine karşı sitotoksik etki gösterirken normal hücrelere etki etmez ve hemolitik etki göstermez. Şimdiye kadar altı parasporin ailesi tanımlanmış olup toplamda 19 alt grup bilinmektedir. Parasporinler de insektisidal kristal proteinlere benzer şekilde reseptör bağlantılı etki gösterdiğinden kanser tedavisiyle ilgili çalışmalarda yeni bir araştırma alanının ortaya çıkmasını sağlamıştır. Bu derlemede; parasporinlerin keşfi, özellikleri, çeşitleri ve etki mekanizmaları hakkında yapılmış olan çalışmalar özetle anlatılmıştır.","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology","grobid_abstract_attachment_id":99969902},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686161/Parasporins_as_a_natural_anti_cancer_protein","translated_internal_url":"","created_at":"2023-03-17T06:03:30.797-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969902,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969902/thumbnails/1.jpg","file_name":"338589.pdf","download_url":"https://www.academia.edu/attachments/99969902/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Parasporins_as_a_natural_anti_cancer_pro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969902/338589-libre.pdf?1679062093=\u0026response-content-disposition=attachment%3B+filename%3DParasporins_as_a_natural_anti_cancer_pro.pdf\u0026Expires=1732984354\u0026Signature=B3w1HTf8tsbfI2HFPId1hJruUtEV3iHSs0TKnHLrPEOyQXLsR8UDjogC5dBRamVayWx7Kj4O5O84hKYa7ZZ4nP7yA03lm0d8jMeg1OMtPK1M75PTMTiiVLmHBbSIXcigafkaDfz4fjxuFUbaV1DvRnuj2vsoKZM2BgyGq5iOAU6NLssV4bh6xcGtpJIi-UMsntpEQfmavBU-50ds2BqtV9iPDlQSpI4G0RxBuMs6kVz7nOkoJBPjjaewmoVYJ3S7Q2TbI9FVYFf1HRf~StwdowC8STQgvcy45ufU2q45TAS2OiXNyvApUooiSRxr88yfdGrOQ90b1y1B2116XvT79A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Parasporins_as_a_natural_anti_cancer_protein","translated_slug":"","page_count":11,"language":"tr","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969902,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969902/thumbnails/1.jpg","file_name":"338589.pdf","download_url":"https://www.academia.edu/attachments/99969902/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Parasporins_as_a_natural_anti_cancer_pro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969902/338589-libre.pdf?1679062093=\u0026response-content-disposition=attachment%3B+filename%3DParasporins_as_a_natural_anti_cancer_pro.pdf\u0026Expires=1732984354\u0026Signature=B3w1HTf8tsbfI2HFPId1hJruUtEV3iHSs0TKnHLrPEOyQXLsR8UDjogC5dBRamVayWx7Kj4O5O84hKYa7ZZ4nP7yA03lm0d8jMeg1OMtPK1M75PTMTiiVLmHBbSIXcigafkaDfz4fjxuFUbaV1DvRnuj2vsoKZM2BgyGq5iOAU6NLssV4bh6xcGtpJIi-UMsntpEQfmavBU-50ds2BqtV9iPDlQSpI4G0RxBuMs6kVz7nOkoJBPjjaewmoVYJ3S7Q2TbI9FVYFf1HRf~StwdowC8STQgvcy45ufU2q45TAS2OiXNyvApUooiSRxr88yfdGrOQ90b1y1B2116XvT79A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":1350274,"name":"Archaeology of Natural Places","url":"https://www.academia.edu/Documents/in/Archaeology_of_Natural_Places"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686160"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686160/Endemik_LathyrusT%C3%BCrlerinin_Antimikrobiyal_Ve_Antit%C3%BCm%C3%B6r_Aktiviteleri"><img alt="Research paper thumbnail of Endemik LathyrusTürlerinin Antimikrobiyal Ve Antitümör Aktiviteleri" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686160/Endemik_LathyrusT%C3%BCrlerinin_Antimikrobiyal_Ve_Antit%C3%BCm%C3%B6r_Aktiviteleri">Endemik LathyrusTürlerinin Antimikrobiyal Ve Antitümör Aktiviteleri</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686160"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686160"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686160; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686160]").text(description); $(".js-view-count[data-work-id=98686160]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686160; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686160']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686160, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686160]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686160,"title":"Endemik LathyrusTürlerinin Antimikrobiyal Ve Antitümör Aktiviteleri","translated_title":"","metadata":{},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686160/Endemik_LathyrusT%C3%BCrlerinin_Antimikrobiyal_Ve_Antit%C3%BCm%C3%B6r_Aktiviteleri","translated_internal_url":"","created_at":"2023-03-17T06:03:30.677-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Endemik_LathyrusTürlerinin_Antimikrobiyal_Ve_Antitümör_Aktiviteleri","translated_slug":"","page_count":null,"language":"tr","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686159"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686159/H_G%C3%BCne%C5%9F_M_Oktay_F_%C3%87elebi_B_T%C3%BCl_Screening_of_antimicrobial_and_anticancer_potentials_of_some_plant_extracts_from_Mugla_provience_Journal_of_Applied_Biological_Sciences_8_16_21_2014_"><img alt="Research paper thumbnail of H. Güneş, M. Oktay, F Çelebi, B Tül. Screening of antimicrobial and anticancer potentials of some plant extracts from Mugla provience. Journal of Applied Biological Sciences, 8: 16-21 (2014)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686159/H_G%C3%BCne%C5%9F_M_Oktay_F_%C3%87elebi_B_T%C3%BCl_Screening_of_antimicrobial_and_anticancer_potentials_of_some_plant_extracts_from_Mugla_provience_Journal_of_Applied_Biological_Sciences_8_16_21_2014_">H. Güneş, M. Oktay, F Çelebi, B Tül. Screening of antimicrobial and anticancer potentials of some plant extracts from Mugla provience. Journal of Applied Biological Sciences, 8: 16-21 (2014)</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686159"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686159"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686159; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686159]").text(description); $(".js-view-count[data-work-id=98686159]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686159; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686159']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686159, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686159]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686159,"title":"H. Güneş, M. Oktay, F Çelebi, B Tül. Screening of antimicrobial and anticancer potentials of some plant extracts from Mugla provience. Journal of Applied Biological Sciences, 8: 16-21 (2014)","translated_title":"","metadata":{},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686159/H_G%C3%BCne%C5%9F_M_Oktay_F_%C3%87elebi_B_T%C3%BCl_Screening_of_antimicrobial_and_anticancer_potentials_of_some_plant_extracts_from_Mugla_provience_Journal_of_Applied_Biological_Sciences_8_16_21_2014_","translated_internal_url":"","created_at":"2023-03-17T06:03:30.574-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"H_Güneş_M_Oktay_F_Çelebi_B_Tül_Screening_of_antimicrobial_and_anticancer_potentials_of_some_plant_extracts_from_Mugla_provience_Journal_of_Applied_Biological_Sciences_8_16_21_2014_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686158"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686158/Sitokinlerin_h%C3%BCcre_d%C3%B6ng%C3%BCs%C3%BC_%C3%BCzerinde_etkileri"><img alt="Research paper thumbnail of Sitokinlerin hücre döngüsü üzerinde etkileri" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686158/Sitokinlerin_h%C3%BCcre_d%C3%B6ng%C3%BCs%C3%BC_%C3%BCzerinde_etkileri">Sitokinlerin hücre döngüsü üzerinde etkileri</a></div><div class="wp-workCard_item"><span>Turkish Journal of Biology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ozet: Sitokinler hucresel duzenleyici proteinlerdir. Vucudun farkli dokularinda ceflitli hucreler...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ozet: Sitokinler hucresel duzenleyici proteinlerdir. Vucudun farkli dokularinda ceflitli hucreler tarafindan belli uyaricilara karfli salgilanip pek cok farkli biyolojik fonksiyonlari kontrol eden sitokinlerin en onemli etkilerinden biri hucre bolunmesi uzerindedir. Bazi sitokinler hucre dongusunun ilerlemesinde pozitif rol oynarken, bazilari hucre bolunmesini engelleyici etki gosterirler. Sitokinlerin hucre bolunmesi uzerindeki pozitif ve negatif etkileri hucre tipine bali olarak deiflir. Burada bazi sitokinlerin hucre dongusu uzerindeki etkilerinin molekuler mekanizmalari anlatilmifltir. Anahtar Sozcukler: Hucre Dongusu, Sitokinler, Buyume faktorleri, TGF-β. Effects of Cytokines on Cell Cycle Abstract: Cytokines are cellular regulatory proteins. They are secreted by specific cells, which are activated by certain stimuli, in different tissues. Cytokines control numerous biological functions and one of their important effects is on cell division. Although some of the cytokines have a positive effect on the cell cycle, some play a negative role. The positive and negative effects of cytokines depend upon the cell type. In this paper, the moleculer mechanisms of cytokine effects on the cell cycle are examined.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686158"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686158"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686158; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686158]").text(description); $(".js-view-count[data-work-id=98686158]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686158; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686158']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686158, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686158]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686158,"title":"Sitokinlerin hücre döngüsü üzerinde etkileri","translated_title":"","metadata":{"abstract":"Ozet: Sitokinler hucresel duzenleyici proteinlerdir. Vucudun farkli dokularinda ceflitli hucreler tarafindan belli uyaricilara karfli salgilanip pek cok farkli biyolojik fonksiyonlari kontrol eden sitokinlerin en onemli etkilerinden biri hucre bolunmesi uzerindedir. Bazi sitokinler hucre dongusunun ilerlemesinde pozitif rol oynarken, bazilari hucre bolunmesini engelleyici etki gosterirler. Sitokinlerin hucre bolunmesi uzerindeki pozitif ve negatif etkileri hucre tipine bali olarak deiflir. Burada bazi sitokinlerin hucre dongusu uzerindeki etkilerinin molekuler mekanizmalari anlatilmifltir. Anahtar Sozcukler: Hucre Dongusu, Sitokinler, Buyume faktorleri, TGF-β. Effects of Cytokines on Cell Cycle Abstract: Cytokines are cellular regulatory proteins. They are secreted by specific cells, which are activated by certain stimuli, in different tissues. Cytokines control numerous biological functions and one of their important effects is on cell division. Although some of the cytokines have a positive effect on the cell cycle, some play a negative role. The positive and negative effects of cytokines depend upon the cell type. In this paper, the moleculer mechanisms of cytokine effects on the cell cycle are examined.","publication_name":"Turkish Journal of Biology"},"translated_abstract":"Ozet: Sitokinler hucresel duzenleyici proteinlerdir. Vucudun farkli dokularinda ceflitli hucreler tarafindan belli uyaricilara karfli salgilanip pek cok farkli biyolojik fonksiyonlari kontrol eden sitokinlerin en onemli etkilerinden biri hucre bolunmesi uzerindedir. Bazi sitokinler hucre dongusunun ilerlemesinde pozitif rol oynarken, bazilari hucre bolunmesini engelleyici etki gosterirler. Sitokinlerin hucre bolunmesi uzerindeki pozitif ve negatif etkileri hucre tipine bali olarak deiflir. Burada bazi sitokinlerin hucre dongusu uzerindeki etkilerinin molekuler mekanizmalari anlatilmifltir. Anahtar Sozcukler: Hucre Dongusu, Sitokinler, Buyume faktorleri, TGF-β. Effects of Cytokines on Cell Cycle Abstract: Cytokines are cellular regulatory proteins. They are secreted by specific cells, which are activated by certain stimuli, in different tissues. Cytokines control numerous biological functions and one of their important effects is on cell division. Although some of the cytokines have a positive effect on the cell cycle, some play a negative role. The positive and negative effects of cytokines depend upon the cell type. In this paper, the moleculer mechanisms of cytokine effects on the cell cycle are examined.","internal_url":"https://www.academia.edu/98686158/Sitokinlerin_h%C3%BCcre_d%C3%B6ng%C3%BCs%C3%BC_%C3%BCzerinde_etkileri","translated_internal_url":"","created_at":"2023-03-17T06:03:30.467-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Sitokinlerin_hücre_döngüsü_üzerinde_etkileri","translated_slug":"","page_count":null,"language":"tr","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686157"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686157/Celenk_yay%C4%B1n_PDF_formu_2008"><img alt="Research paper thumbnail of Celenk yayın PDF formu 2008" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686157/Celenk_yay%C4%B1n_PDF_formu_2008">Celenk yayın PDF formu 2008</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686157"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686157"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686157; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686157]").text(description); $(".js-view-count[data-work-id=98686157]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686157; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686157']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686157, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686157]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686157,"title":"Celenk yayın PDF formu 2008","translated_title":"","metadata":{},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686157/Celenk_yay%C4%B1n_PDF_formu_2008","translated_internal_url":"","created_at":"2023-03-17T06:03:30.359-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Celenk_yayın_PDF_formu_2008","translated_slug":"","page_count":null,"language":"tr","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686156"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686156/H746635193663U36_BTpaper_Apayd%C4%B1n_O"><img alt="Research paper thumbnail of H746635193663U36 (BTpaper Apaydın O" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686156/H746635193663U36_BTpaper_Apayd%C4%B1n_O">H746635193663U36 (BTpaper Apaydın O</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686156"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686156"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686156; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686156]").text(description); $(".js-view-count[data-work-id=98686156]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686156; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686156']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686156, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686156]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686156,"title":"H746635193663U36 (BTpaper Apaydın O","translated_title":"","metadata":{},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686156/H746635193663U36_BTpaper_Apayd%C4%B1n_O","translated_internal_url":"","created_at":"2023-03-17T06:03:30.247-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"H746635193663U36_BTpaper_Apaydın_O","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686155"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686155/The_expression_of_forms_of_prolactin_receptors_in_splenocytes_and_thymocytes_of_neonatal_rats_the_effect_of_milk_ingestion"><img alt="Research paper thumbnail of The expression of forms of prolactin receptors in splenocytes and thymocytes of neonatal rats: the effect of milk ingestion" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686155/The_expression_of_forms_of_prolactin_receptors_in_splenocytes_and_thymocytes_of_neonatal_rats_the_effect_of_milk_ingestion">The expression of forms of prolactin receptors in splenocytes and thymocytes of neonatal rats: the effect of milk ingestion</a></div><div class="wp-workCard_item"><span>Endocrine regulations</span><span>, 1993</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Because prolactin (PRL) plays a role in neonatal immune development, we examined the expression o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Because prolactin (PRL) plays a role in neonatal immune development, we examined the expression of prolactin receptors (PRL-R) in neonatal lymphoid tissues. We had shown previously that deprivation of milk-borne PRL, days 2-5 in the neonatal rat, leads to enhanced in vitro mitogenesis of thymocytes and splenocytes as well as a change in lymphoid-specific, cell surface antigens (GROVE et al. 1991). In this present study, we asked if neonatal lymphocytes express PRL-R; which forms of PRL-R are expressed (long vs. short form); when these forms are expressed during development; and if milk ingestion plays a role in receptor expression. Two approaches were taken using neonatal rat thymocytes and splenocytes: RNA was analyzed by polymerase chain reaction (PCR) and cells were stained with antibody to PRL-R and analyzed by flow cytometry. In regard to cell surface expression, the percentage of PRL-R positive splenocytes was greater than thymocytes at all ages tested. In the spleen, the perc...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686155"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686155"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686155; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686155]").text(description); $(".js-view-count[data-work-id=98686155]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686155; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686155']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686155, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686155]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686155,"title":"The expression of forms of prolactin receptors in splenocytes and thymocytes of neonatal rats: the effect of milk ingestion","translated_title":"","metadata":{"abstract":"Because prolactin (PRL) plays a role in neonatal immune development, we examined the expression of prolactin receptors (PRL-R) in neonatal lymphoid tissues. We had shown previously that deprivation of milk-borne PRL, days 2-5 in the neonatal rat, leads to enhanced in vitro mitogenesis of thymocytes and splenocytes as well as a change in lymphoid-specific, cell surface antigens (GROVE et al. 1991). In this present study, we asked if neonatal lymphocytes express PRL-R; which forms of PRL-R are expressed (long vs. short form); when these forms are expressed during development; and if milk ingestion plays a role in receptor expression. Two approaches were taken using neonatal rat thymocytes and splenocytes: RNA was analyzed by polymerase chain reaction (PCR) and cells were stained with antibody to PRL-R and analyzed by flow cytometry. In regard to cell surface expression, the percentage of PRL-R positive splenocytes was greater than thymocytes at all ages tested. In the spleen, the perc...","publication_date":{"day":null,"month":null,"year":1993,"errors":{}},"publication_name":"Endocrine regulations"},"translated_abstract":"Because prolactin (PRL) plays a role in neonatal immune development, we examined the expression of prolactin receptors (PRL-R) in neonatal lymphoid tissues. We had shown previously that deprivation of milk-borne PRL, days 2-5 in the neonatal rat, leads to enhanced in vitro mitogenesis of thymocytes and splenocytes as well as a change in lymphoid-specific, cell surface antigens (GROVE et al. 1991). In this present study, we asked if neonatal lymphocytes express PRL-R; which forms of PRL-R are expressed (long vs. short form); when these forms are expressed during development; and if milk ingestion plays a role in receptor expression. Two approaches were taken using neonatal rat thymocytes and splenocytes: RNA was analyzed by polymerase chain reaction (PCR) and cells were stained with antibody to PRL-R and analyzed by flow cytometry. In regard to cell surface expression, the percentage of PRL-R positive splenocytes was greater than thymocytes at all ages tested. In the spleen, the perc...","internal_url":"https://www.academia.edu/98686155/The_expression_of_forms_of_prolactin_receptors_in_splenocytes_and_thymocytes_of_neonatal_rats_the_effect_of_milk_ingestion","translated_internal_url":"","created_at":"2023-03-17T06:03:30.132-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_expression_of_forms_of_prolactin_receptors_in_splenocytes_and_thymocytes_of_neonatal_rats_the_effect_of_milk_ingestion","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":64657,"name":"Prolactin","url":"https://www.academia.edu/Documents/in/Prolactin"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction"},{"id":238368,"name":"Milk","url":"https://www.academia.edu/Documents/in/Milk"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":396894,"name":"Ingestion","url":"https://www.academia.edu/Documents/in/Ingestion"},{"id":555007,"name":"Receptor","url":"https://www.academia.edu/Documents/in/Receptor"},{"id":809882,"name":"Base Sequence","url":"https://www.academia.edu/Documents/in/Base_Sequence"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data"},{"id":3881526,"name":"In Vitro Techniques","url":"https://www.academia.edu/Documents/in/In_Vitro_Techniques"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686154"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686154/Distribution_occurrence_of_cry_genes_and_lepidopteran_toxicity_of_native_Bacillus_thuringiensis_isolated_from_fig_tree_environments_in_Ayd%C4%B1n_Province"><img alt="Research paper thumbnail of Distribution, occurrence of cry genes, and lepidopteran toxicity of native Bacillus thuringiensis isolated from fig tree environments in Aydın Province" class="work-thumbnail" src="https://attachments.academia-assets.com/99969900/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686154/Distribution_occurrence_of_cry_genes_and_lepidopteran_toxicity_of_native_Bacillus_thuringiensis_isolated_from_fig_tree_environments_in_Ayd%C4%B1n_Province">Distribution, occurrence of cry genes, and lepidopteran toxicity of native Bacillus thuringiensis isolated from fig tree environments in Aydın Province</a></div><div class="wp-workCard_item"><span>TURKISH JOURNAL OF AGRICULTURE AND FORESTRY</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2a8d3acdc28a6b750caeed0df1661961" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969900,"asset_id":98686154,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969900/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686154"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686154"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686154; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686154]").text(description); $(".js-view-count[data-work-id=98686154]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686154; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686154']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686154, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2a8d3acdc28a6b750caeed0df1661961" } } $('.js-work-strip[data-work-id=98686154]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686154,"title":"Distribution, occurrence of cry genes, and lepidopteran toxicity of native Bacillus thuringiensis isolated from fig tree environments in Aydın Province","translated_title":"","metadata":{"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","grobid_abstract":"Bacillus thuringiensis (Bt) has a significant impact on biological pest control because of the insecticidal activity through its parasporal inclusion bodies (crystal proteins). Fig is an economically important plant in Turkey; agricultural pests result in a considerable economic loss in fig quality and cultivation. The aim of this work was to isolate, characterize, and determine the lepidopteran toxicity of Bt obtained from fig groves in Aydın Province. A total of 606 colonies (out of 1167) obtained from 380 samples were identified as Bt based on parasporal crystal formation. The highest Bt index of 0.60 was observed in the Kuyucak region. A total of 288 Bt isolates were characterized in terms of cry gene content by PCR analysis. It was found that the cry1 plus cry2 genotype was the most abundant (40%) in our collection. Bioactivity tests indicated that 6 isolates exhibited high mortalities against Cadra cautella and 3 isolates were found to exhibit high toxicity against Carpophilus hemipterus. Moreover, 13 Bt isolates exhibiting toxic activity against fig pests were further characterized based on specific cry gene content, protein profiles, and PCR-RFLP analysis. Among cry1 genes, the cry1Aa, cry1Ab, cry1Ac, cry1B, cry1C, cry1D, and cry1Ea genes were the most frequent (100%). Protein profiles of isolates toxic to C. cautella were different from those of isolates toxic to C. hemipterus. PCR-RFLP analysis indicated that toxic isolates differed from the reference strain with respect to cry1 type gene. Finally, it was concluded that Bt strains isolated from fig groves showed high level of toxicity against fig pests. These strains can serve as potential biopesticides for the control of C. cautella in the region as well as alternative biopesticides in the case of pesticide resistance in insects.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"TURKISH JOURNAL OF AGRICULTURE AND FORESTRY","grobid_abstract_attachment_id":99969900},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686154/Distribution_occurrence_of_cry_genes_and_lepidopteran_toxicity_of_native_Bacillus_thuringiensis_isolated_from_fig_tree_environments_in_Ayd%C4%B1n_Province","translated_internal_url":"","created_at":"2023-03-17T06:03:30.010-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969900,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969900/thumbnails/1.jpg","file_name":"78fa301f0453d9e6a13830ec77a39b6dd864.pdf","download_url":"https://www.academia.edu/attachments/99969900/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Distribution_occurrence_of_cry_genes_and.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969900/78fa301f0453d9e6a13830ec77a39b6dd864-libre.pdf?1679062084=\u0026response-content-disposition=attachment%3B+filename%3DDistribution_occurrence_of_cry_genes_and.pdf\u0026Expires=1732984354\u0026Signature=ANPr2gWkr0AJpsrGGZFIBGF4X1TR7Y9TWdLRfdPr6tSiNzA3aLD9tZjjyxg3DBjN-We1hoLvcIzDKsZsS-DFRmiv0QbSuyayCTxIrbfVfVms4ssrcPBqRXfcq8GI8jikvUa~rzFmvL4-rcS2nKbXwJIGfzw7IanPGnzJCvQVkyuYL5~s3pfPnSrDdtLdi2bYyqWupllnrJ3JZYqMiJnIvBB389T7giMT7FQh9rhYhGMNg2Xm5mIxFsgQAfGg9n-Q4nOZYXWpcxyWDHsPt4PvaZodlVApIugQB5BZfmji9H94eu1IytWWWUUdeXB8cS-uRchRw5-lf01WQIjL7eoatQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Distribution_occurrence_of_cry_genes_and_lepidopteran_toxicity_of_native_Bacillus_thuringiensis_isolated_from_fig_tree_environments_in_Aydın_Province","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969900,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969900/thumbnails/1.jpg","file_name":"78fa301f0453d9e6a13830ec77a39b6dd864.pdf","download_url":"https://www.academia.edu/attachments/99969900/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Distribution_occurrence_of_cry_genes_and.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969900/78fa301f0453d9e6a13830ec77a39b6dd864-libre.pdf?1679062084=\u0026response-content-disposition=attachment%3B+filename%3DDistribution_occurrence_of_cry_genes_and.pdf\u0026Expires=1732984354\u0026Signature=ANPr2gWkr0AJpsrGGZFIBGF4X1TR7Y9TWdLRfdPr6tSiNzA3aLD9tZjjyxg3DBjN-We1hoLvcIzDKsZsS-DFRmiv0QbSuyayCTxIrbfVfVms4ssrcPBqRXfcq8GI8jikvUa~rzFmvL4-rcS2nKbXwJIGfzw7IanPGnzJCvQVkyuYL5~s3pfPnSrDdtLdi2bYyqWupllnrJ3JZYqMiJnIvBB389T7giMT7FQh9rhYhGMNg2Xm5mIxFsgQAfGg9n-Q4nOZYXWpcxyWDHsPt4PvaZodlVApIugQB5BZfmji9H94eu1IytWWWUUdeXB8cS-uRchRw5-lf01WQIjL7eoatQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":67768,"name":"Bacillus thuringiensis","url":"https://www.academia.edu/Documents/in/Bacillus_thuringiensis"},{"id":181936,"name":"Gene","url":"https://www.academia.edu/Documents/in/Gene"},{"id":988766,"name":"Bioactivity","url":"https://www.academia.edu/Documents/in/Bioactivity"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686153"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686153/RFLP_of_16S_ITSrDNA_Region_to_Differentiate_Lactobacilli_at_Species_Level"><img alt="Research paper thumbnail of RFLP of 16S-ITSrDNA Region to Differentiate Lactobacilli at Species Level" class="work-thumbnail" src="https://attachments.academia-assets.com/99969908/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686153/RFLP_of_16S_ITSrDNA_Region_to_Differentiate_Lactobacilli_at_Species_Level">RFLP of 16S-ITSrDNA Region to Differentiate Lactobacilli at Species Level</a></div><div class="wp-workCard_item"><span>World Journal of Microbiology and Biotechnology</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f670f082db0832c0a569888bf855ce81" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969908,"asset_id":98686153,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969908/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686153"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686153"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686153; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686153]").text(description); $(".js-view-count[data-work-id=98686153]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686153; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686153']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686153, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f670f082db0832c0a569888bf855ce81" } } $('.js-work-strip[data-work-id=98686153]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686153,"title":"RFLP of 16S-ITSrDNA Region to Differentiate Lactobacilli at Species Level","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","grobid_abstract":"The 16S-ITS (internal transcribed spacer) region of the rrn operon was amplified by polymerase chain reaction (PCR). The amplification products were analysed by restriction fragment length polymorphism (RFLP) using a set of restriction enzymes, AluI, HaeIII, and TaqI. Restriction pattern analyses revealed that TaqI restriction enzyme could clearly differentiate the nine reference strains of Lactobacillus used in the study.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"World Journal of Microbiology and Biotechnology","grobid_abstract_attachment_id":99969908},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686153/RFLP_of_16S_ITSrDNA_Region_to_Differentiate_Lactobacilli_at_Species_Level","translated_internal_url":"","created_at":"2023-03-17T06:03:29.886-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969908,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969908/thumbnails/1.jpg","file_name":"4728.pdf","download_url":"https://www.academia.edu/attachments/99969908/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"RFLP_of_16S_ITSrDNA_Region_to_Differenti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969908/4728-libre.pdf?1679062075=\u0026response-content-disposition=attachment%3B+filename%3DRFLP_of_16S_ITSrDNA_Region_to_Differenti.pdf\u0026Expires=1732984354\u0026Signature=QR7D1GqHp3QCReEV553QUqQdnjltM6tksIOoyGswuOiF3uR2RFZp-zfLNXqj7eBNGXMCe8jU2mOHe4wRBQ37uXZWw5ebw6TpgBUwcn6Zf0vmvkmePtVIAGCXYVqHQ~DNU5R9kJj-kSg4qyvd-9NXyWTaDKCP4hgpQIhxn-IVt0xvxc1fpGGaalOA1ulwLpntmKzgzJUd80ldk~N3HZ3tDBw9hwn2Pd34vLz8oaCRyaKG2983~0kplocpbE01~oEvp3bG8-g7uLUMT8G5LYvhTqBZ2spXtx9SbLN91gj-K8yRFDzmDYImQQzj~EgDUThaibrASDEV4l3RT7aGOBVhDA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"RFLP_of_16S_ITSrDNA_Region_to_Differentiate_Lactobacilli_at_Species_Level","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969908,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969908/thumbnails/1.jpg","file_name":"4728.pdf","download_url":"https://www.academia.edu/attachments/99969908/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"RFLP_of_16S_ITSrDNA_Region_to_Differenti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969908/4728-libre.pdf?1679062075=\u0026response-content-disposition=attachment%3B+filename%3DRFLP_of_16S_ITSrDNA_Region_to_Differenti.pdf\u0026Expires=1732984354\u0026Signature=QR7D1GqHp3QCReEV553QUqQdnjltM6tksIOoyGswuOiF3uR2RFZp-zfLNXqj7eBNGXMCe8jU2mOHe4wRBQ37uXZWw5ebw6TpgBUwcn6Zf0vmvkmePtVIAGCXYVqHQ~DNU5R9kJj-kSg4qyvd-9NXyWTaDKCP4hgpQIhxn-IVt0xvxc1fpGGaalOA1ulwLpntmKzgzJUd80ldk~N3HZ3tDBw9hwn2Pd34vLz8oaCRyaKG2983~0kplocpbE01~oEvp3bG8-g7uLUMT8G5LYvhTqBZ2spXtx9SbLN91gj-K8yRFDzmDYImQQzj~EgDUThaibrASDEV4l3RT7aGOBVhDA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":923,"name":"Technology","url":"https://www.academia.edu/Documents/in/Technology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":73606,"name":"World","url":"https://www.academia.edu/Documents/in/World"},{"id":74144,"name":"Lactic Acid Bacteria","url":"https://www.academia.edu/Documents/in/Lactic_Acid_Bacteria"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction"},{"id":2579012,"name":"restriction enzyme","url":"https://www.academia.edu/Documents/in/restriction_enzyme"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686152"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686152/Prolactin_and_The_Development_of_The_Neonatal_Immune_System"><img alt="Research paper thumbnail of Prolactin and The Development of The Neonatal Immune System" class="work-thumbnail" src="https://attachments.academia-assets.com/99969903/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686152/Prolactin_and_The_Development_of_The_Neonatal_Immune_System">Prolactin and The Development of The Neonatal Immune System</a></div><div class="wp-workCard_item"><span>Pediatric Research</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0985a2c694b4607f124d0e354bd2d775" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969903,"asset_id":98686152,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969903/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686152"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686152"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686152; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686152]").text(description); $(".js-view-count[data-work-id=98686152]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686152; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686152']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686152, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0985a2c694b4607f124d0e354bd2d775" } } $('.js-work-strip[data-work-id=98686152]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686152,"title":"Prolactin and The Development of The Neonatal Immune System","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Pediatric Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686152/Prolactin_and_The_Development_of_The_Neonatal_Immune_System","translated_internal_url":"","created_at":"2023-03-17T06:03:29.765-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969903,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969903/thumbnails/1.jpg","file_name":"pr19992273.pdf","download_url":"https://www.academia.edu/attachments/99969903/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prolactin_and_The_Development_of_The_Neo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969903/pr19992273-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DProlactin_and_The_Development_of_The_Neo.pdf\u0026Expires=1732984354\u0026Signature=GurqkQxjVAM8h2uORjZPClqfzUgchkJOA2qkZWEOWznsf1JzR8a2X-DVzb8D~5qsvUTc~HkvhKBOxVnvC5bHQCT6oQdt2NdV5BYxwejFYk~He-pkfNJP3U9Xw8tJgrP36Q01oHt-eI9KWYQkgQpl-JHBNYSyI~KBo-FuAzFAEDfBZqgEqb5OPNSWTDtb5nM5MHEs9c2~cYcpjypUGdwRBq6-GYzVmzWUrW-~rS0bcQBeHxUF3WBbHMEL1CDiMBcKcG55rwqpBnyBdrIDJZ8JZU8-J~JN3t0rEZicXCamx6MAU2LiRXbbqjRmvZnM1Zg07d1w6nYXzwAuVj46TRxU8g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Prolactin_and_The_Development_of_The_Neonatal_Immune_System","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969903,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969903/thumbnails/1.jpg","file_name":"pr19992273.pdf","download_url":"https://www.academia.edu/attachments/99969903/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prolactin_and_The_Development_of_The_Neo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969903/pr19992273-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DProlactin_and_The_Development_of_The_Neo.pdf\u0026Expires=1732984354\u0026Signature=GurqkQxjVAM8h2uORjZPClqfzUgchkJOA2qkZWEOWznsf1JzR8a2X-DVzb8D~5qsvUTc~HkvhKBOxVnvC5bHQCT6oQdt2NdV5BYxwejFYk~He-pkfNJP3U9Xw8tJgrP36Q01oHt-eI9KWYQkgQpl-JHBNYSyI~KBo-FuAzFAEDfBZqgEqb5OPNSWTDtb5nM5MHEs9c2~cYcpjypUGdwRBq6-GYzVmzWUrW-~rS0bcQBeHxUF3WBbHMEL1CDiMBcKcG55rwqpBnyBdrIDJZ8JZU8-J~JN3t0rEZicXCamx6MAU2LiRXbbqjRmvZnM1Zg07d1w6nYXzwAuVj46TRxU8g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":64657,"name":"Prolactin","url":"https://www.academia.edu/Documents/in/Prolactin"},{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686151"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686151/Homofermentative_lactic_acid_bacteria_of_a_traditional_cheese_Comlek_peyniri_from_Cappadocia_region"><img alt="Research paper thumbnail of Homofermentative lactic acid bacteria of a traditional cheese, Comlek peyniri from Cappadocia region" class="work-thumbnail" src="https://attachments.academia-assets.com/99969912/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686151/Homofermentative_lactic_acid_bacteria_of_a_traditional_cheese_Comlek_peyniri_from_Cappadocia_region">Homofermentative lactic acid bacteria of a traditional cheese, Comlek peyniri from Cappadocia region</a></div><div class="wp-workCard_item"><span>Journal of Dairy Research</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Comlek peyniri is a typical artisanal cheese in Central Anatolia. This type of cheese was made by...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Comlek peyniri is a typical artisanal cheese in Central Anatolia. This type of cheese was made by using the indigenous lactic acid bacteria (LAB) flora of cow or ewes&#39; milk. Majority of the samples were taken from fresh cheese because the aim was to isolate homofermentative LAB. Initially 661 microbial isolates were obtained from 17 cheese samples. Only 107 were found to be homofermentative LAB. These isolates were selected and identified by using both phenotypic and molecular methods. Phenotypic identification included curd formation from skim milk, catalase test, Gram staining and light microscopy, growth at different temperatures and salt concentrations, arginine hydrolysis, gas production from glucose, and carbohydrate fermentation. Molecular identification was based on the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of the 16S rRNA gene-ITS (internally transcribed spacer) region. By combining the phenotypic and molecular identification resu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4d0807b21fbda91875ecac7c5dae9587" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969912,"asset_id":98686151,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969912/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686151"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686151"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686151; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686151]").text(description); $(".js-view-count[data-work-id=98686151]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686151; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686151']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686151, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4d0807b21fbda91875ecac7c5dae9587" } } $('.js-work-strip[data-work-id=98686151]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686151,"title":"Homofermentative lactic acid bacteria of a traditional cheese, Comlek peyniri from Cappadocia region","translated_title":"","metadata":{"abstract":"Comlek peyniri is a typical artisanal cheese in Central Anatolia. This type of cheese was made by using the indigenous lactic acid bacteria (LAB) flora of cow or ewes\u0026#39; milk. Majority of the samples were taken from fresh cheese because the aim was to isolate homofermentative LAB. Initially 661 microbial isolates were obtained from 17 cheese samples. Only 107 were found to be homofermentative LAB. These isolates were selected and identified by using both phenotypic and molecular methods. Phenotypic identification included curd formation from skim milk, catalase test, Gram staining and light microscopy, growth at different temperatures and salt concentrations, arginine hydrolysis, gas production from glucose, and carbohydrate fermentation. Molecular identification was based on the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of the 16S rRNA gene-ITS (internally transcribed spacer) region. By combining the phenotypic and molecular identification resu...","publisher":"Cambridge University Press (CUP)","publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Journal of Dairy Research"},"translated_abstract":"Comlek peyniri is a typical artisanal cheese in Central Anatolia. This type of cheese was made by using the indigenous lactic acid bacteria (LAB) flora of cow or ewes\u0026#39; milk. Majority of the samples were taken from fresh cheese because the aim was to isolate homofermentative LAB. Initially 661 microbial isolates were obtained from 17 cheese samples. Only 107 were found to be homofermentative LAB. These isolates were selected and identified by using both phenotypic and molecular methods. Phenotypic identification included curd formation from skim milk, catalase test, Gram staining and light microscopy, growth at different temperatures and salt concentrations, arginine hydrolysis, gas production from glucose, and carbohydrate fermentation. Molecular identification was based on the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of the 16S rRNA gene-ITS (internally transcribed spacer) region. By combining the phenotypic and molecular identification resu...","internal_url":"https://www.academia.edu/98686151/Homofermentative_lactic_acid_bacteria_of_a_traditional_cheese_Comlek_peyniri_from_Cappadocia_region","translated_internal_url":"","created_at":"2023-03-17T06:03:29.584-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969912,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969912/thumbnails/1.jpg","file_name":"7070fcddfb9152d9aaebff67a6a437ee95dc.pdf","download_url":"https://www.academia.edu/attachments/99969912/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Homofermentative_lactic_acid_bacteria_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969912/7070fcddfb9152d9aaebff67a6a437ee95dc-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DHomofermentative_lactic_acid_bacteria_of.pdf\u0026Expires=1732984354\u0026Signature=BVTMuWAVZrZg3dzE2oglN6a0fhcVtAnqKwmu~XUOGBz-Ry2fUxzAgTAM0HupK~KpBDhJ~qOziz01Yh7JQmRai7gW~mwxQ3WyEugb4XDKU8RXarrKVqyhEVSk0PftK4~o9I75B0xBP4gtof7BWLCR0EKv7e0jj-GoCqaH85sWBFBf9mGVNiCQGbyOP7D3pybT9RzO-WuGDOd1cLnOO4Drgqf~vjvq6nM6jdubXHjsfdEgMenirTt8k3UECqAI3qE56YMr-EbIiYmixl9-k6LhZJvmWn6qf~JM5hoOtypfs0dQW5vdk2go7DW9FiwE18lg2WY4KguafH9SNDcR1mNieQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Homofermentative_lactic_acid_bacteria_of_a_traditional_cheese_Comlek_peyniri_from_Cappadocia_region","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969912,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969912/thumbnails/1.jpg","file_name":"7070fcddfb9152d9aaebff67a6a437ee95dc.pdf","download_url":"https://www.academia.edu/attachments/99969912/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Homofermentative_lactic_acid_bacteria_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969912/7070fcddfb9152d9aaebff67a6a437ee95dc-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DHomofermentative_lactic_acid_bacteria_of.pdf\u0026Expires=1732984354\u0026Signature=BVTMuWAVZrZg3dzE2oglN6a0fhcVtAnqKwmu~XUOGBz-Ry2fUxzAgTAM0HupK~KpBDhJ~qOziz01Yh7JQmRai7gW~mwxQ3WyEugb4XDKU8RXarrKVqyhEVSk0PftK4~o9I75B0xBP4gtof7BWLCR0EKv7e0jj-GoCqaH85sWBFBf9mGVNiCQGbyOP7D3pybT9RzO-WuGDOd1cLnOO4Drgqf~vjvq6nM6jdubXHjsfdEgMenirTt8k3UECqAI3qE56YMr-EbIiYmixl9-k6LhZJvmWn6qf~JM5hoOtypfs0dQW5vdk2go7DW9FiwE18lg2WY4KguafH9SNDcR1mNieQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1040,"name":"Food Science","url":"https://www.academia.edu/Documents/in/Food_Science"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":10966,"name":"Turkey","url":"https://www.academia.edu/Documents/in/Turkey"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29980,"name":"Animal Production","url":"https://www.academia.edu/Documents/in/Animal_Production"},{"id":63353,"name":"Identification","url":"https://www.academia.edu/Documents/in/Identification"},{"id":74144,"name":"Lactic Acid Bacteria","url":"https://www.academia.edu/Documents/in/Lactic_Acid_Bacteria"},{"id":113903,"name":"Bacteria","url":"https://www.academia.edu/Documents/in/Bacteria"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction"},{"id":181926,"name":"Dairy","url":"https://www.academia.edu/Documents/in/Dairy"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":238368,"name":"Milk","url":"https://www.academia.edu/Documents/in/Milk"},{"id":251661,"name":"Cheese","url":"https://www.academia.edu/Documents/in/Cheese"},{"id":269129,"name":"Fermentation","url":"https://www.academia.edu/Documents/in/Fermentation"},{"id":427784,"name":"Enterococcus","url":"https://www.academia.edu/Documents/in/Enterococcus"},{"id":573653,"name":"Food Sciences","url":"https://www.academia.edu/Documents/in/Food_Sciences"},{"id":599635,"name":"Cambridge University","url":"https://www.academia.edu/Documents/in/Cambridge_University"},{"id":1074508,"name":"Lactic Acid","url":"https://www.academia.edu/Documents/in/Lactic_Acid"},{"id":1242119,"name":"Lactococcus lactis","url":"https://www.academia.edu/Documents/in/Lactococcus_lactis"}],"urls":[{"id":29866545,"url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0022029904000536"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686150"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686150/Identification_of_extracellular_enzyme_producing_thermophilic_bacilli_from_Balcova_Agamemnon_geothermal_site_by_ITS_rDNA_RFLP"><img alt="Research paper thumbnail of Identification of extracellular enzyme producing thermophilic bacilli from Balcova (Agamemnon) geothermal site by ITS rDNA RFLP" class="work-thumbnail" src="https://attachments.academia-assets.com/99969917/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686150/Identification_of_extracellular_enzyme_producing_thermophilic_bacilli_from_Balcova_Agamemnon_geothermal_site_by_ITS_rDNA_RFLP">Identification of extracellular enzyme producing thermophilic bacilli from Balcova (Agamemnon) geothermal site by ITS rDNA RFLP</a></div><div class="wp-workCard_item"><span>Journal of Applied Microbiology</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="02f692257f1c21939ab81a84ae6fcb38" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969917,"asset_id":98686150,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969917/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686150"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686150"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686150; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686150]").text(description); $(".js-view-count[data-work-id=98686150]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686150; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686150']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686150, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "02f692257f1c21939ab81a84ae6fcb38" } } $('.js-work-strip[data-work-id=98686150]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686150,"title":"Identification of extracellular enzyme producing thermophilic bacilli from Balcova (Agamemnon) geothermal site by ITS rDNA RFLP","translated_title":"","metadata":{"publisher":"Oxford University Press (OUP)","ai_title_tag":"Thermophilic Bacilli with Extracellular Enzymes from Balcova","grobid_abstract":"Aims: Molecular characterization of extracellular enzyme producing thermophilic bacilli from Balcova geothermal site. Methods and Results: Three types of geothermal samples were collected: mud, re-injection water, and samples from uncontrolled hydrothermal vents. Isolates grown at 55°C in culture media prepared in sterilized re-injection water, were screened for extracellular enzyme activity by using eight different substrates: casein, carboxymethylcellulose, pectin, polygalacturonic acid (PGA), soluble starch, Tween 20 and 80, and xylan. In total, 109 thermoaerophilic isolates were selected. All of the isolates could hydrolyse Tween 20 (100%) but not Tween 80. Soluble starch was hydrolysed by 96%, casein by 55%, xylan and carboxymethylcellulose by 9%, and pectin and PGA by 2% of the isolates. The isolates were grouped into 14 different homology groups by the restriction pattern analysis of 16S-internal transcribed spacer (ITS) rDNA RFLP. Each of the RFLP groups was also studied by 16S rRNA gene partial sequence analysis. Plasmid DNA profiles revealed that 15 of the isolated strains contained small plasmid DNA molecules ranging in size from 12 000 to 35 000 bp. Conclusions: Combined analysis of 16S-ITS rDNA RFLP and 16S rRNA gene partial sequence results indicated the presence of novel or existing species of Anoxybacillus (nine species) and Geobacillus (three species). Significance and Impact of the Study: In this study 16S-ITS rDNA RFLP was applied for the first time to differentiate thermophilic bacilli. It was also the first study on thermophilic bacilli of Balcova geothermal site.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Journal of Applied Microbiology","grobid_abstract_attachment_id":99969917},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686150/Identification_of_extracellular_enzyme_producing_thermophilic_bacilli_from_Balcova_Agamemnon_geothermal_site_by_ITS_rDNA_RFLP","translated_internal_url":"","created_at":"2023-03-17T06:03:29.110-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969917,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969917/thumbnails/1.jpg","file_name":"4729.pdf","download_url":"https://www.academia.edu/attachments/99969917/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Identification_of_extracellular_enzyme_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969917/4729-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_extracellular_enzyme_p.pdf\u0026Expires=1732984354\u0026Signature=EOLUMJkwoYMhu1zX6dmesFUGtW7MK4LnqpYZ~E4CvwxckH1awJO0m56CVbcZ5tFuFo~VFbPUgkK44uGEugB3ZYjL~jJnDVnFcAuxoCXKv2b5KKwpPXKac076YBw~Ys7WLgu7ojmh4lfONFOoLiNea2ousLZG6O~q-a~YFlGLYRY~ekc1SOM1X-0Jl-fbkynZU7fd~mPpN3JOmo9VQjGCakt0p6TCyWft7i2WgIJyUgMoaNqtSBX9yCc1aX9ek8nZfw7nDn7Wfj-hxTfGENJg5O29~lw1E6qukfs0tnsDOkwdKs77Y5Z2w8j0g~ext0ADlGcjTs3im~Tk2IVbOVOMcQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Identification_of_extracellular_enzyme_producing_thermophilic_bacilli_from_Balcova_Agamemnon_geothermal_site_by_ITS_rDNA_RFLP","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969917,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969917/thumbnails/1.jpg","file_name":"4729.pdf","download_url":"https://www.academia.edu/attachments/99969917/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Identification_of_extracellular_enzyme_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969917/4729-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_extracellular_enzyme_p.pdf\u0026Expires=1732984354\u0026Signature=EOLUMJkwoYMhu1zX6dmesFUGtW7MK4LnqpYZ~E4CvwxckH1awJO0m56CVbcZ5tFuFo~VFbPUgkK44uGEugB3ZYjL~jJnDVnFcAuxoCXKv2b5KKwpPXKac076YBw~Ys7WLgu7ojmh4lfONFOoLiNea2ousLZG6O~q-a~YFlGLYRY~ekc1SOM1X-0Jl-fbkynZU7fd~mPpN3JOmo9VQjGCakt0p6TCyWft7i2WgIJyUgMoaNqtSBX9yCc1aX9ek8nZfw7nDn7Wfj-hxTfGENJg5O29~lw1E6qukfs0tnsDOkwdKs77Y5Z2w8j0g~ext0ADlGcjTs3im~Tk2IVbOVOMcQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":7730,"name":"Geothermal","url":"https://www.academia.edu/Documents/in/Geothermal"},{"id":19703,"name":"Applied microbiology","url":"https://www.academia.edu/Documents/in/Applied_microbiology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":54433,"name":"Phylogeny","url":"https://www.academia.edu/Documents/in/Phylogeny"},{"id":112332,"name":"Bacillus","url":"https://www.academia.edu/Documents/in/Bacillus"},{"id":168196,"name":"Horses","url":"https://www.academia.edu/Documents/in/Horses"},{"id":190363,"name":"Plasmids","url":"https://www.academia.edu/Documents/in/Plasmids"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":231547,"name":"Soil Microbiology","url":"https://www.academia.edu/Documents/in/Soil_Microbiology"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme"},{"id":469102,"name":"Feces","url":"https://www.academia.edu/Documents/in/Feces"},{"id":526690,"name":"Similarity analysis","url":"https://www.academia.edu/Documents/in/Similarity_analysis"},{"id":676195,"name":"Pectins","url":"https://www.academia.edu/Documents/in/Pectins"},{"id":809882,"name":"Base Sequence","url":"https://www.academia.edu/Documents/in/Base_Sequence"},{"id":1925906,"name":"Bacilli","url":"https://www.academia.edu/Documents/in/Bacilli"},{"id":2545897,"name":"Hot Springs","url":"https://www.academia.edu/Documents/in/Hot_Springs"}],"urls":[{"id":29866544,"url":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1365-2672.2004.02374.x/fullpdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686149"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686149/Prolactin_receptor_gene_expression_in_rat_splenocytes_and_thymocytes_during_oestrous_cycle_pregnancy_and_lactation"><img alt="Research paper thumbnail of Prolactin receptor gene expression in rat splenocytes and thymocytes during oestrous cycle, pregnancy and lactation" class="work-thumbnail" src="https://attachments.academia-assets.com/99969914/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686149/Prolactin_receptor_gene_expression_in_rat_splenocytes_and_thymocytes_during_oestrous_cycle_pregnancy_and_lactation">Prolactin receptor gene expression in rat splenocytes and thymocytes during oestrous cycle, pregnancy and lactation</a></div><div class="wp-workCard_item"><span>Cell Proliferation</span><span>, 1997</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8e29fe3989b998ae46a3810aab75cc95" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969914,"asset_id":98686149,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969914/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686149"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686149"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686149; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686149]").text(description); $(".js-view-count[data-work-id=98686149]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686149; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686149']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686149, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8e29fe3989b998ae46a3810aab75cc95" } } $('.js-work-strip[data-work-id=98686149]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686149,"title":"Prolactin receptor gene expression in rat splenocytes and thymocytes during oestrous cycle, pregnancy and lactation","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"Much evidence suggests that prolactin (PRL) has an immunoregulatory function. Part of this evidence is that the receptors for PRL are present on lymphocytes. Probably the effects of PRL on cells of the immune system depend on the level and specific forms of PRL-R present on the target cells. Therefore, PRL-R expression at both protein and mRNA levels was examined during oestrous cycle, pregnancy and lactation using Western blotting and PCR analysis. Antibody to the long form of PRL-R detected 84 and 42 kDa protein bands in the spleen but only 84 kDa band in the thymus. The expression pattern of these two protein bands was different in the spleen, suggesting that these two isoforms of PRL-R long form are differentially regulated by the hormones of oestrous cycle. In addition, depending on the tissue, the level of mRNA for the short and long forms of PRL-R showed a significant change at different stages of oestrous cycle. Moreover, 42 and 84 kDa PRL-R bands were detected in both spleen and thymus throughout the pregnancy and lactation; however, the expression pattern of 84 kDa protein band was different between tissues. This finding suggests that each tissue exhibits differential response to hormones which affect PRL-R content. An anterior pituitary hormone PRL is primarily responsible for the development of mammary gland and the stimulation of milk protein genes. In addition, it has effect on reproduction, growth, metabolism, behaviour and immunoregulation. Immunoregulatory function of PRL has been supported by many studies. For example, decreased antibody production as well as cell mediated immunity have been observed in hypohysectomized rats (Nagy \u0026-Berczi 1978). Administration of PRL or implantation of pituitary gland reconstituted these immune functions (Berczi et al. 1981, Nagy et al. 1983). In addition, PRL has been shown to regulate DNA synthesis in vivo in lymphoid tissue (Berczi et al. 1991) and to act directly on splenocytes and thymocytes in vitro (Mukherjee et al. 1990, Viselli, Stanek \u0026 Mukherjee 1991). PRL-R expression has been shown in lymphoid cells. For example, binding studics with '2sI-labelled PRL provided evidence that human T-and B-cells have PRL-R (Russell 1985). More definitive studies based on the use of antibodies to PRL-R and flow cytometry confirmed these findings; and indicated that many subsets of rat splenocytes (Viselli \u0026 Mastro 1Y93), rat and murine lymphoid cells (Koh \u0026 Phillips 1YY3, Gagnerault et al.","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"Cell Proliferation","grobid_abstract_attachment_id":99969914},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686149/Prolactin_receptor_gene_expression_in_rat_splenocytes_and_thymocytes_during_oestrous_cycle_pregnancy_and_lactation","translated_internal_url":"","created_at":"2023-03-17T06:03:28.935-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969914,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969914/thumbnails/1.jpg","file_name":"4499.pdf","download_url":"https://www.academia.edu/attachments/99969914/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prolactin_receptor_gene_expression_in_ra.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969914/4499-libre.pdf?1679062083=\u0026response-content-disposition=attachment%3B+filename%3DProlactin_receptor_gene_expression_in_ra.pdf\u0026Expires=1732984354\u0026Signature=Lvv8yZhE-eOe2H2JQQIi1D~Re8qCAE9V3k6EyjyM8nUKCX4fv~pcgTf2KT7tPCiXJSu7xk2QJD7ZWFniO7ZcED-YP5W-YDAg1jOxeHO1M8P2cgMP7cAVmfEysl1DsSO-hk9olE-fN3x-ZJt8WHGq2lol75m9IwlF~93Pp3urbfJMWcJ8-cDflU0GjETu4JNnWuNrJhl5D8pwQ7Y~EvS4DUqkM2QZ69li2dhS5XL33fCi0FurkMUef39RgXj2Mj4M0QaJeHDaZ7kgvW2fYof-sPuh2XwEAXMmD9iJkr7dBKOaVrr2kUOujra4Oe2NCl26c8fnup09957k3EuaSHKC8g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Prolactin_receptor_gene_expression_in_rat_splenocytes_and_thymocytes_during_oestrous_cycle_pregnancy_and_lactation","translated_slug":"","page_count":17,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969914,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969914/thumbnails/1.jpg","file_name":"4499.pdf","download_url":"https://www.academia.edu/attachments/99969914/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prolactin_receptor_gene_expression_in_ra.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969914/4499-libre.pdf?1679062083=\u0026response-content-disposition=attachment%3B+filename%3DProlactin_receptor_gene_expression_in_ra.pdf\u0026Expires=1732984354\u0026Signature=Lvv8yZhE-eOe2H2JQQIi1D~Re8qCAE9V3k6EyjyM8nUKCX4fv~pcgTf2KT7tPCiXJSu7xk2QJD7ZWFniO7ZcED-YP5W-YDAg1jOxeHO1M8P2cgMP7cAVmfEysl1DsSO-hk9olE-fN3x-ZJt8WHGq2lol75m9IwlF~93Pp3urbfJMWcJ8-cDflU0GjETu4JNnWuNrJhl5D8pwQ7Y~EvS4DUqkM2QZ69li2dhS5XL33fCi0FurkMUef39RgXj2Mj4M0QaJeHDaZ7kgvW2fYof-sPuh2XwEAXMmD9iJkr7dBKOaVrr2kUOujra4Oe2NCl26c8fnup09957k3EuaSHKC8g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":19826,"name":"Lactation","url":"https://www.academia.edu/Documents/in/Lactation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":64657,"name":"Prolactin","url":"https://www.academia.edu/Documents/in/Prolactin"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence"},{"id":906079,"name":"Antibody Detection","url":"https://www.academia.edu/Documents/in/Antibody_Detection"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"},{"id":1847499,"name":"Estrous cycle","url":"https://www.academia.edu/Documents/in/Estrous_cycle"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data"},{"id":2950546,"name":"Animal cell","url":"https://www.academia.edu/Documents/in/Animal_cell"}],"urls":[{"id":29866543,"url":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1365-2184.1997.tb00936.x/fullpdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="17348733" id="papers"><div class="js-work-strip profile--work_container" data-work-id="98686168"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686168/Cytotoxic_Activities_of_Certain_Medicinal_Plants_on_Different_Cancer_Cell_Lines"><img alt="Research paper thumbnail of Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines" class="work-thumbnail" src="https://attachments.academia-assets.com/99969924/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686168/Cytotoxic_Activities_of_Certain_Medicinal_Plants_on_Different_Cancer_Cell_Lines">Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines</a></div><div class="wp-workCard_item"><span>Turkish Journal of Pharmaceutical Sciences</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4ec777e470d24a2b7b340ee2a7bf1221" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969924,"asset_id":98686168,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969924/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686168"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686168"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686168; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686168]").text(description); $(".js-view-count[data-work-id=98686168]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686168; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686168']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686168, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4ec777e470d24a2b7b340ee2a7bf1221" } } $('.js-work-strip[data-work-id=98686168]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686168,"title":"Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines","translated_title":"","metadata":{"publisher":"Galenos Yayinevi","grobid_abstract":"Son yıllarda kanserin önlenmesi ve tedavisi için, farklı sınıfta fitokimyasal içerikleri ve daha az yan etkileri nedeniyle bitkilerin kullanımı oldukça önem kazanmaktadır. Bu çalışmada, Türkiye'nin Kars ilinden toplanan dört farklı tıbbi bitki türünün altı farklı kanser hücre hattı ve bir normal hücre hattı üzerindeki sitotoksik etkileri incelenmiştir. Gereç ve Yöntemler: Sitotoksik aktivite MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-dipenyltetrazolium bromide] yöntemiyle belirlenirken, apoptotik hücre ölümü akış sitometri ve kaspaz-3 analizleriyle tespit edilmiştir. Bulgular: Artemisia absinthium yaprak özütü A-549, CCC-221, K-562, MCF-7, PC-3 hücre hatları üzerinde anlamlı sitotoksik etki (≥%70) gösterirken, tohum özütü ise CCC-221, K-562, MCF-7, PC-3 hücreleri üzerinde anlamlı sitotoksik etki (≥%70) göstermiştir. Normal hücre hattı Beas-2B hücresine kıyasla, seçici sitotoksik aktivite yaprak özütüyle A-549 ve K-562 hücreleri üzerinde gözlenirken, tohum özütüyle K-562, MCF-7 ve PC-3 hücreleri üzerinde gözlenmiştir. Her iki özütün sitotoksisite seviyesi düşük konsantrasyonlarda zaman ve doza bağlı olarak değişmektedir. İlave olarak, Plantago major bitki özütüyle A-549 hücreleri üzerinde seçici sitotoksisite (%78) elde edilmiştir. Hyoscyamus niger ve Amaranthus retrosa özütlerinin sitotoksisite aktivitesinin %10 ve %30 olduğu gözlenmiştir. Sonuç: A. absinthium özütleri ve P. major tohum özütü gelecek çalışmalarda bazı kanser hücrelerinin sitotoksisitesi için tedavi edici ilaç geliştirilmesi potansiyeline sahiptirler.","publication_name":"Turkish Journal of Pharmaceutical Sciences","grobid_abstract_attachment_id":99969924},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686168/Cytotoxic_Activities_of_Certain_Medicinal_Plants_on_Different_Cancer_Cell_Lines","translated_internal_url":"","created_at":"2023-03-17T06:03:31.788-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969924,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969924/thumbnails/1.jpg","file_name":"TJPS-14-3.pdf","download_url":"https://www.academia.edu/attachments/99969924/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cytotoxic_Activities_of_Certain_Medicina.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969924/TJPS-14-3-libre.pdf?1679062085=\u0026response-content-disposition=attachment%3B+filename%3DCytotoxic_Activities_of_Certain_Medicina.pdf\u0026Expires=1732984353\u0026Signature=K2bV599y~Ida6Nhb-jMQth3UpYO863PN1SgmnTiQF0LxLcXIhAkjsApm96Fn1jv1S3hF7UuTELS1mgtG2zic0zvoBc~GbtKgcbbmet-6c4sjctqeUyvCOCwFUpu~Bq42u3OEyxlWRAF6L9vtxsSLb9aZRxszt35ANSlGlgZH27BZDcKDv4YMLpXo8tDNDy4ihghJpvZMeZljZUP~2PUfEhRUwOwnn0Ef7JdQPS30LPJBSHgdE-6HeZ5h2nJr621czzdzhFf-EVUBkVCKGaQeuHk-eD9VwfeKdmy6omFbOumPJj5N6GOw9qu4HXGPtdSsI5imIkyhfc2fffO8zvb6lg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cytotoxic_Activities_of_Certain_Medicinal_Plants_on_Different_Cancer_Cell_Lines","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969924,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969924/thumbnails/1.jpg","file_name":"TJPS-14-3.pdf","download_url":"https://www.academia.edu/attachments/99969924/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cytotoxic_Activities_of_Certain_Medicina.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969924/TJPS-14-3-libre.pdf?1679062085=\u0026response-content-disposition=attachment%3B+filename%3DCytotoxic_Activities_of_Certain_Medicina.pdf\u0026Expires=1732984353\u0026Signature=K2bV599y~Ida6Nhb-jMQth3UpYO863PN1SgmnTiQF0LxLcXIhAkjsApm96Fn1jv1S3hF7UuTELS1mgtG2zic0zvoBc~GbtKgcbbmet-6c4sjctqeUyvCOCwFUpu~Bq42u3OEyxlWRAF6L9vtxsSLb9aZRxszt35ANSlGlgZH27BZDcKDv4YMLpXo8tDNDy4ihghJpvZMeZljZUP~2PUfEhRUwOwnn0Ef7JdQPS30LPJBSHgdE-6HeZ5h2nJr621czzdzhFf-EVUBkVCKGaQeuHk-eD9VwfeKdmy6omFbOumPJj5N6GOw9qu4HXGPtdSsI5imIkyhfc2fffO8zvb6lg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":15019,"name":"Medicinal Plants","url":"https://www.academia.edu/Documents/in/Medicinal_Plants"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":41720,"name":"Human","url":"https://www.academia.edu/Documents/in/Human"},{"id":112576,"name":"Cell Death","url":"https://www.academia.edu/Documents/in/Cell_Death"},{"id":169415,"name":"Article","url":"https://www.academia.edu/Documents/in/Article"},{"id":247477,"name":"Caspase","url":"https://www.academia.edu/Documents/in/Caspase"},{"id":369262,"name":"Amaranthus","url":"https://www.academia.edu/Documents/in/Amaranthus"},{"id":468970,"name":"Drug effect","url":"https://www.academia.edu/Documents/in/Drug_effect"},{"id":546352,"name":"Controlled Study","url":"https://www.academia.edu/Documents/in/Controlled_Study"},{"id":553283,"name":"Cancer cells","url":"https://www.academia.edu/Documents/in/Cancer_cells"},{"id":584594,"name":"Drug Efficacy","url":"https://www.academia.edu/Documents/in/Drug_Efficacy"},{"id":1134083,"name":"Medicinal Plant","url":"https://www.academia.edu/Documents/in/Medicinal_Plant"},{"id":1316597,"name":"Human Cell","url":"https://www.academia.edu/Documents/in/Human_Cell"},{"id":2034545,"name":"Hyoscyamus","url":"https://www.academia.edu/Documents/in/Hyoscyamus"},{"id":2254256,"name":"Artemisia Absinthium","url":"https://www.academia.edu/Documents/in/Artemisia_Absinthium"},{"id":2487926,"name":"drug response","url":"https://www.academia.edu/Documents/in/drug_response"},{"id":3887567,"name":"Antineoplastic activity","url":"https://www.academia.edu/Documents/in/Antineoplastic_activity"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686167"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686167/Solanum_lycopersicum_Yaprak_Ekstrakt%C4%B1n%C4%B1n_Farkl%C4%B1_%C4%B0nsan_H%C3%BCcre_Hatlar%C4%B1ndaki_Sitotoksik_Potansiyeli"><img alt="Research paper thumbnail of Solanum lycopersicum Yaprak Ekstraktının Farklı İnsan Hücre Hatlarındaki Sitotoksik Potansiyeli" class="work-thumbnail" src="https://attachments.academia-assets.com/99969905/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686167/Solanum_lycopersicum_Yaprak_Ekstrakt%C4%B1n%C4%B1n_Farkl%C4%B1_%C4%B0nsan_H%C3%BCcre_Hatlar%C4%B1ndaki_Sitotoksik_Potansiyeli">Solanum lycopersicum Yaprak Ekstraktının Farklı İnsan Hücre Hatlarındaki Sitotoksik Potansiyeli</a></div><div class="wp-workCard_item"><span>Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5d1e4b9af3fe88ead37db11685ceb0e9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969905,"asset_id":98686167,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969905/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686167"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686167"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686167; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686167]").text(description); $(".js-view-count[data-work-id=98686167]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686167; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686167']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686167, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5d1e4b9af3fe88ead37db11685ceb0e9" } } $('.js-work-strip[data-work-id=98686167]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686167,"title":"Solanum lycopersicum Yaprak Ekstraktının Farklı İnsan Hücre Hatlarındaki Sitotoksik Potansiyeli","translated_title":"","metadata":{"publisher":"Bilecik Seyh Edebali Universitesi Fen Bilimleri Dergisi","grobid_abstract":"Bitkiler geleneksel olarak çeşitli hastalıklara karşı çare olarak kullanılmaktadır. Bu çalışmada Solanum lycopersicum yapraklarının etanol ekstraktının potansiyel sitotoksik etkileri A549, HeLa, PC-3, MCF-7 ve HEK293 hücre hatlarında araştırılmıştır. Hücre canlılığının belirlenmesi için MTT deneyi kullanılmıştır. Ekstarakt ile muamele edilen A549 ve HeLa hücrelerinde apoptoz ve kaspaz-3 aktivitesi araştırılmıştır. 31.25 µg mL-1 konsantrasyonda, bu ekstrakt, 72 saatte test edilen kanser hücrelerinde % 50'den fazla sitotoksisiteye neden olmuştur. S. lycopersicum ekstraktının A549 ve HeLa hücrelerinde apoptozu indüklediği belirlenmiştir. Ayrıca, S. lycopersicum yapraklarının ekstresi aynı hücrelerde önemli kaspaz-3 aktivitesine neden olmuştur. Bu bulgular temel olarak antikanser ajanların gelişimi için S. lycopersicum yaprak ekstraktının kullanımı ile ilgili araştırmalara katkıda bulunabilir.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi","grobid_abstract_attachment_id":99969905},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686167/Solanum_lycopersicum_Yaprak_Ekstrakt%C4%B1n%C4%B1n_Farkl%C4%B1_%C4%B0nsan_H%C3%BCcre_Hatlar%C4%B1ndaki_Sitotoksik_Potansiyeli","translated_internal_url":"","created_at":"2023-03-17T06:03:31.670-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969905/thumbnails/1.jpg","file_name":"949948.pdf","download_url":"https://www.academia.edu/attachments/99969905/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Solanum_lycopersicum_Yaprak_Ekstraktinin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969905/949948-libre.pdf?1679062085=\u0026response-content-disposition=attachment%3B+filename%3DSolanum_lycopersicum_Yaprak_Ekstraktinin.pdf\u0026Expires=1732984353\u0026Signature=ak78TI2YTArgvEBBRnTUdOpfSChN-p5WrXuptobHQfAE7sycI8YKiX8VSVyW8lQfv8of6wL-i8xLySYVo4wMmzEZy5mFgjsReuzm5svYkaETGW9U14m7EfvQ4yaZsOp7~p45vP0HK-Vm~KydGljixkwSLH0veHlQV0V8deCLQVp9BaUuUGtAj~3Bc0w1wQyGH3xwJFIbJ5QCZA1Tg1rNRDz8BQnhzGrl0kbhnzWEcXhlg4NOxfgggbgcTNrgFSTRwH1uwrDjLls4V0mEIkxeQjgYyDCkTvb2Qe0B66mHz83zXlcSntDjfjf2H7bDv~4anctuqmzMNH7vnhFoZfpC5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Solanum_lycopersicum_Yaprak_Ekstraktının_Farklı_İnsan_Hücre_Hatlarındaki_Sitotoksik_Potansiyeli","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969905/thumbnails/1.jpg","file_name":"949948.pdf","download_url":"https://www.academia.edu/attachments/99969905/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Solanum_lycopersicum_Yaprak_Ekstraktinin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969905/949948-libre.pdf?1679062085=\u0026response-content-disposition=attachment%3B+filename%3DSolanum_lycopersicum_Yaprak_Ekstraktinin.pdf\u0026Expires=1732984353\u0026Signature=ak78TI2YTArgvEBBRnTUdOpfSChN-p5WrXuptobHQfAE7sycI8YKiX8VSVyW8lQfv8of6wL-i8xLySYVo4wMmzEZy5mFgjsReuzm5svYkaETGW9U14m7EfvQ4yaZsOp7~p45vP0HK-Vm~KydGljixkwSLH0veHlQV0V8deCLQVp9BaUuUGtAj~3Bc0w1wQyGH3xwJFIbJ5QCZA1Tg1rNRDz8BQnhzGrl0kbhnzWEcXhlg4NOxfgggbgcTNrgFSTRwH1uwrDjLls4V0mEIkxeQjgYyDCkTvb2Qe0B66mHz83zXlcSntDjfjf2H7bDv~4anctuqmzMNH7vnhFoZfpC5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":474180,"name":"Solanum","url":"https://www.academia.edu/Documents/in/Solanum"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686166"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686166/Determination_of_the_effects_of_biomaterials_on_human_peripheral_blood_mononuclear_cells_PBMC_"><img alt="Research paper thumbnail of Determination of the effects of biomaterials on human peripheral blood mononuclear cells (PBMC)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686166/Determination_of_the_effects_of_biomaterials_on_human_peripheral_blood_mononuclear_cells_PBMC_">Determination of the effects of biomaterials on human peripheral blood mononuclear cells (PBMC)</a></div><div class="wp-workCard_item"><span>Technology and Health Care</span><span>, Sep 19, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT End-stage liver disease accounts for over 30,000 deaths annually in the United States. O...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT End-stage liver disease accounts for over 30,000 deaths annually in the United States. Orthotopic liver transplantation is the only clinically proven treatment for patients with end-stage liver failure. A limitation of this therapy is a shortage of donor ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686166"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686166"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686166; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686166]").text(description); $(".js-view-count[data-work-id=98686166]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686166; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686166']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686166, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686166]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686166,"title":"Determination of the effects of biomaterials on human peripheral blood mononuclear cells (PBMC)","translated_title":"","metadata":{"abstract":"ABSTRACT End-stage liver disease accounts for over 30,000 deaths annually in the United States. Orthotopic liver transplantation is the only clinically proven treatment for patients with end-stage liver failure. A limitation of this therapy is a shortage of donor ...","publisher":"IOS Press","publication_date":{"day":19,"month":9,"year":2002,"errors":{}},"publication_name":"Technology and Health Care"},"translated_abstract":"ABSTRACT End-stage liver disease accounts for over 30,000 deaths annually in the United States. Orthotopic liver transplantation is the only clinically proven treatment for patients with end-stage liver failure. A limitation of this therapy is a shortage of donor ...","internal_url":"https://www.academia.edu/98686166/Determination_of_the_effects_of_biomaterials_on_human_peripheral_blood_mononuclear_cells_PBMC_","translated_internal_url":"","created_at":"2023-03-17T06:03:31.498-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Determination_of_the_effects_of_biomaterials_on_human_peripheral_blood_mononuclear_cells_PBMC_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":2698,"name":"Biomaterials","url":"https://www.academia.edu/Documents/in/Biomaterials"},{"id":4594,"name":"Carbon Dioxide","url":"https://www.academia.edu/Documents/in/Carbon_Dioxide"},{"id":57799,"name":"Biocompatibility","url":"https://www.academia.edu/Documents/in/Biocompatibility"},{"id":849784,"name":"Health Care Technology","url":"https://www.academia.edu/Documents/in/Health_Care_Technology"},{"id":1198580,"name":"Mononuclear Cells","url":"https://www.academia.edu/Documents/in/Mononuclear_Cells"},{"id":1309704,"name":"Protein Determination","url":"https://www.academia.edu/Documents/in/Protein_Determination"},{"id":3833419,"name":"Peripheral blood","url":"https://www.academia.edu/Documents/in/Peripheral_blood"}],"urls":[{"id":29866548,"url":"https://dl.acm.org/doi/10.5555/781744.781782"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686165"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686165/Antibacterial_and_Antitumor_Activity_of_Crude_Methanolic_Extracts_from_Various_Macrofungi_Species"><img alt="Research paper thumbnail of Antibacterial and Antitumor Activity of Crude Methanolic Extracts from Various Macrofungi Species" class="work-thumbnail" src="https://attachments.academia-assets.com/99969858/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686165/Antibacterial_and_Antitumor_Activity_of_Crude_Methanolic_Extracts_from_Various_Macrofungi_Species">Antibacterial and Antitumor Activity of Crude Methanolic Extracts from Various Macrofungi Species</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mushrooms are considered to be an important natural resource for the investigation of new compoun...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mushrooms are considered to be an important natural resource for the investigation of new compounds with antimicrobial, anti-tumor orimmunomodulatory effects because of their secondary metabolites and degrading enzymes. In this study, antibacterial and antitumorpotential of Cantharellus cibarius, Clitocybe geotropa, Gyromitra esculenta, Lactarius delicious, Melanoleuca exscissa, Ramaria flava,Sarcosphaera crassa, Morchella sp., Stereum hirsutum and Trametes versicolor mushrooms collected from Mugla region have beeninvestigated with disc diffusion method and MTT assay, respectively. Among all mushroom extracts, M. exscissa extract showed the highestantimicrobial effect on E. coli (22 mm, 80 µg/disc inhibition zone). It was observed that 8 out of 16 mushroom extracts did not show anyeffect on all test microorganisms, the others formed up to 9 mm inhibition zone in diameters. In addition, a total of 16 mushroom extracts(400 µg/ml) were tested on 5 different cancer cell lines. It was de...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="212764924367221722252fda50894b84" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969858,"asset_id":98686165,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969858/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686165"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686165"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686165; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686165]").text(description); $(".js-view-count[data-work-id=98686165]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686165; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686165']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686165, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "212764924367221722252fda50894b84" } } $('.js-work-strip[data-work-id=98686165]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686165,"title":"Antibacterial and Antitumor Activity of Crude Methanolic Extracts from Various Macrofungi Species","translated_title":"","metadata":{"abstract":"Mushrooms are considered to be an important natural resource for the investigation of new compounds with antimicrobial, anti-tumor orimmunomodulatory effects because of their secondary metabolites and degrading enzymes. In this study, antibacterial and antitumorpotential of Cantharellus cibarius, Clitocybe geotropa, Gyromitra esculenta, Lactarius delicious, Melanoleuca exscissa, Ramaria flava,Sarcosphaera crassa, Morchella sp., Stereum hirsutum and Trametes versicolor mushrooms collected from Mugla region have beeninvestigated with disc diffusion method and MTT assay, respectively. Among all mushroom extracts, M. exscissa extract showed the highestantimicrobial effect on E. coli (22 mm, 80 µg/disc inhibition zone). It was observed that 8 out of 16 mushroom extracts did not show anyeffect on all test microorganisms, the others formed up to 9 mm inhibition zone in diameters. In addition, a total of 16 mushroom extracts(400 µg/ml) were tested on 5 different cancer cell lines. It was de...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"Mushrooms are considered to be an important natural resource for the investigation of new compounds with antimicrobial, anti-tumor orimmunomodulatory effects because of their secondary metabolites and degrading enzymes. In this study, antibacterial and antitumorpotential of Cantharellus cibarius, Clitocybe geotropa, Gyromitra esculenta, Lactarius delicious, Melanoleuca exscissa, Ramaria flava,Sarcosphaera crassa, Morchella sp., Stereum hirsutum and Trametes versicolor mushrooms collected from Mugla region have beeninvestigated with disc diffusion method and MTT assay, respectively. Among all mushroom extracts, M. exscissa extract showed the highestantimicrobial effect on E. coli (22 mm, 80 µg/disc inhibition zone). It was observed that 8 out of 16 mushroom extracts did not show anyeffect on all test microorganisms, the others formed up to 9 mm inhibition zone in diameters. In addition, a total of 16 mushroom extracts(400 µg/ml) were tested on 5 different cancer cell lines. It was de...","internal_url":"https://www.academia.edu/98686165/Antibacterial_and_Antitumor_Activity_of_Crude_Methanolic_Extracts_from_Various_Macrofungi_Species","translated_internal_url":"","created_at":"2023-03-17T06:03:31.339-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969858,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969858/thumbnails/1.jpg","file_name":"257.pdf","download_url":"https://www.academia.edu/attachments/99969858/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Antibacterial_and_Antitumor_Activity_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969858/257-libre.pdf?1679062087=\u0026response-content-disposition=attachment%3B+filename%3DAntibacterial_and_Antitumor_Activity_of.pdf\u0026Expires=1732984353\u0026Signature=ERRyBhMaBDoq2Z8rbc9MKoVZGUCNP1NG3Epxa6yy0dr9MF2h5dYtACCkrAB3DQzWd~C6p0ggV8R9t7IcA9DFnXqsUGtfp6slAX8Dtr~uii8HutLxeB55qG9O5OjLN0sQzt6CnqHCs7xrBWwXnDew2PQXCK2YfhTaKyIpPdN9olUieAbAwif0rd8QsLahbwpDMQSntYV8Q5wa-l-XyBcRQQpnM7czBuF8BDHYHOVkegrEm9kbin854KSqbXME7oNkNErivaow7OgT7pNxCBIzDDfr6QLQ3YFlD9AFy4WvkAZk92rgA5oXCnGkM1lSVm0VN5dP~TJBEiSGDroi8kd~hQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Antibacterial_and_Antitumor_Activity_of_Crude_Methanolic_Extracts_from_Various_Macrofungi_Species","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969858,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969858/thumbnails/1.jpg","file_name":"257.pdf","download_url":"https://www.academia.edu/attachments/99969858/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Antibacterial_and_Antitumor_Activity_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969858/257-libre.pdf?1679062087=\u0026response-content-disposition=attachment%3B+filename%3DAntibacterial_and_Antitumor_Activity_of.pdf\u0026Expires=1732984353\u0026Signature=ERRyBhMaBDoq2Z8rbc9MKoVZGUCNP1NG3Epxa6yy0dr9MF2h5dYtACCkrAB3DQzWd~C6p0ggV8R9t7IcA9DFnXqsUGtfp6slAX8Dtr~uii8HutLxeB55qG9O5OjLN0sQzt6CnqHCs7xrBWwXnDew2PQXCK2YfhTaKyIpPdN9olUieAbAwif0rd8QsLahbwpDMQSntYV8Q5wa-l-XyBcRQQpnM7czBuF8BDHYHOVkegrEm9kbin854KSqbXME7oNkNErivaow7OgT7pNxCBIzDDfr6QLQ3YFlD9AFy4WvkAZk92rgA5oXCnGkM1lSVm0VN5dP~TJBEiSGDroi8kd~hQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":94562,"name":"Mushroom","url":"https://www.academia.edu/Documents/in/Mushroom"},{"id":220036,"name":"Antimicrobial","url":"https://www.academia.edu/Documents/in/Antimicrobial"},{"id":3287348,"name":"biology sciences","url":"https://www.academia.edu/Documents/in/biology_sciences-1"}],"urls":[{"id":29866547,"url":"http://bibad.gen.tr/index.php/bibad/article/download/258/257"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686164"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686164/Anticancer_effect_of_the_fruit_and_seed_extracts_of_Momordica_charantia_L_Cucurbitaceae_on_human_cancer_cell_lines"><img alt="Research paper thumbnail of Anticancer effect of the fruit and seed extracts of Momordica charantia L. (Cucurbitaceae) on human cancer cell lines" class="work-thumbnail" src="https://attachments.academia-assets.com/99969855/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686164/Anticancer_effect_of_the_fruit_and_seed_extracts_of_Momordica_charantia_L_Cucurbitaceae_on_human_cancer_cell_lines">Anticancer effect of the fruit and seed extracts of Momordica charantia L. (Cucurbitaceae) on human cancer cell lines</a></div><div class="wp-workCard_item"><span>Tropical Journal of Pharmaceutical Research</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose: To investigate anticancer effects of Momordica charantia L. (M. charantia) fruit and see...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose: To investigate anticancer effects of Momordica charantia L. (M. charantia) fruit and seed extracts on some cancer cell lines. Methods: Human cancer cell lines, including lung cancer (A549), breast cancer (MCF-7), chronic myeloid leukemia (K562) and T cell leukemia (Jurkat) were incubated with the extracts (0 - 0.8 mg/mL) for 72 h. The cytotoxic effects of the extracts were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5- dipenyltetrazolium bromide (MTT) assay. A549 and MCF-7 cells were treated with the ethanol fruit extract (FE) for 24 h and stained with propidium iodide (PI) for the analysis of cell cycle arrest using flow cytometry. Annexin V-FITC/PI staining along with flow cytometry analysis and caspase-3 assays were carried out to determine the apoptosis of the cells treated with FE extract for 24 h. Vascular endothelial growth factor (VEGF) secretion of the cells exposed to FE extract for 1 h was determined using enzyme-linked immunosorbent assay (ELISA). Cell invas...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="af9fec81167fffea0500020d67b60104" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969855,"asset_id":98686164,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969855/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686164"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686164"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686164; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686164]").text(description); $(".js-view-count[data-work-id=98686164]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686164; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686164']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686164, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "af9fec81167fffea0500020d67b60104" } } $('.js-work-strip[data-work-id=98686164]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686164,"title":"Anticancer effect of the fruit and seed extracts of Momordica charantia L. (Cucurbitaceae) on human cancer cell lines","translated_title":"","metadata":{"abstract":"Purpose: To investigate anticancer effects of Momordica charantia L. (M. charantia) fruit and seed extracts on some cancer cell lines. Methods: Human cancer cell lines, including lung cancer (A549), breast cancer (MCF-7), chronic myeloid leukemia (K562) and T cell leukemia (Jurkat) were incubated with the extracts (0 - 0.8 mg/mL) for 72 h. The cytotoxic effects of the extracts were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5- dipenyltetrazolium bromide (MTT) assay. A549 and MCF-7 cells were treated with the ethanol fruit extract (FE) for 24 h and stained with propidium iodide (PI) for the analysis of cell cycle arrest using flow cytometry. Annexin V-FITC/PI staining along with flow cytometry analysis and caspase-3 assays were carried out to determine the apoptosis of the cells treated with FE extract for 24 h. Vascular endothelial growth factor (VEGF) secretion of the cells exposed to FE extract for 1 h was determined using enzyme-linked immunosorbent assay (ELISA). Cell invas...","publisher":"African Journals Online (AJOL)","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Tropical Journal of Pharmaceutical Research"},"translated_abstract":"Purpose: To investigate anticancer effects of Momordica charantia L. (M. charantia) fruit and seed extracts on some cancer cell lines. Methods: Human cancer cell lines, including lung cancer (A549), breast cancer (MCF-7), chronic myeloid leukemia (K562) and T cell leukemia (Jurkat) were incubated with the extracts (0 - 0.8 mg/mL) for 72 h. The cytotoxic effects of the extracts were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5- dipenyltetrazolium bromide (MTT) assay. A549 and MCF-7 cells were treated with the ethanol fruit extract (FE) for 24 h and stained with propidium iodide (PI) for the analysis of cell cycle arrest using flow cytometry. Annexin V-FITC/PI staining along with flow cytometry analysis and caspase-3 assays were carried out to determine the apoptosis of the cells treated with FE extract for 24 h. Vascular endothelial growth factor (VEGF) secretion of the cells exposed to FE extract for 1 h was determined using enzyme-linked immunosorbent assay (ELISA). Cell invas...","internal_url":"https://www.academia.edu/98686164/Anticancer_effect_of_the_fruit_and_seed_extracts_of_Momordica_charantia_L_Cucurbitaceae_on_human_cancer_cell_lines","translated_internal_url":"","created_at":"2023-03-17T06:03:31.155-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969855,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969855/thumbnails/1.jpg","file_name":"197849.pdf","download_url":"https://www.academia.edu/attachments/99969855/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Anticancer_effect_of_the_fruit_and_seed.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969855/197849-libre.pdf?1679062084=\u0026response-content-disposition=attachment%3B+filename%3DAnticancer_effect_of_the_fruit_and_seed.pdf\u0026Expires=1732984354\u0026Signature=PxSx5ujBpTtLGnI2LhE56cV~zB~y9JADg~xodZeRCyfk1f~eiHJofHPibgPkOIq4cBbgFzBn3lP~7HOX7b07hv5X8o-OCEl7cjbRcCoOk1pwx79dd1R74Bj3rj5T9yboY972FDGhIvQrG0IdJk1~Cc4GE8NTxjayMhTCKCnES6BBhtkUPLZ4gaUHAIhZd2VvpbaVnym5s7-OV7yLX7zlayZCPzebe5zEx~l0wdF4B0zJV2UKlX6aMu4TzTSWTcJc0PA-gB6I4AvhxIUYI3HsKn8GDt8~83OjA2cmmX9iSFqFgTxhrJ9OU7XEMUizdBBjcA4BuHuI7fZz4D1kQLtD0A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Anticancer_effect_of_the_fruit_and_seed_extracts_of_Momordica_charantia_L_Cucurbitaceae_on_human_cancer_cell_lines","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969855,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969855/thumbnails/1.jpg","file_name":"197849.pdf","download_url":"https://www.academia.edu/attachments/99969855/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Anticancer_effect_of_the_fruit_and_seed.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969855/197849-libre.pdf?1679062084=\u0026response-content-disposition=attachment%3B+filename%3DAnticancer_effect_of_the_fruit_and_seed.pdf\u0026Expires=1732984354\u0026Signature=PxSx5ujBpTtLGnI2LhE56cV~zB~y9JADg~xodZeRCyfk1f~eiHJofHPibgPkOIq4cBbgFzBn3lP~7HOX7b07hv5X8o-OCEl7cjbRcCoOk1pwx79dd1R74Bj3rj5T9yboY972FDGhIvQrG0IdJk1~Cc4GE8NTxjayMhTCKCnES6BBhtkUPLZ4gaUHAIhZd2VvpbaVnym5s7-OV7yLX7zlayZCPzebe5zEx~l0wdF4B0zJV2UKlX6aMu4TzTSWTcJc0PA-gB6I4AvhxIUYI3HsKn8GDt8~83OjA2cmmX9iSFqFgTxhrJ9OU7XEMUizdBBjcA4BuHuI7fZz4D1kQLtD0A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":768729,"name":"Momordica","url":"https://www.academia.edu/Documents/in/Momordica"},{"id":1335154,"name":"Propidium Iodide","url":"https://www.academia.edu/Documents/in/Propidium_Iodide"},{"id":2272583,"name":"MTT assay","url":"https://www.academia.edu/Documents/in/MTT_assay"}],"urls":[{"id":29866546,"url":"https://www.ajol.info/index.php/tjpr/article/download/209844/197849"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686163"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686163/The_Anticancer_and_Anti_inflammatory_Effects_of_Centaurea_solstitialis_Extract_on_Human_Cancer_Cell_Lines"><img alt="Research paper thumbnail of The Anticancer and Anti-inflammatory Effects of Centaurea solstitialis Extract on Human Cancer Cell Lines" class="work-thumbnail" src="https://attachments.academia-assets.com/99969907/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686163/The_Anticancer_and_Anti_inflammatory_Effects_of_Centaurea_solstitialis_Extract_on_Human_Cancer_Cell_Lines">The Anticancer and Anti-inflammatory Effects of Centaurea solstitialis Extract on Human Cancer Cell Lines</a></div><div class="wp-workCard_item"><span>Turkish Journal of Pharmaceutical Sciences</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fe8d91bce9dff025efab71d10f872153" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969907,"asset_id":98686163,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969907/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686163"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686163"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686163; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686163]").text(description); $(".js-view-count[data-work-id=98686163]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686163; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686163']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686163, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fe8d91bce9dff025efab71d10f872153" } } $('.js-work-strip[data-work-id=98686163]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686163,"title":"The Anticancer and Anti-inflammatory Effects of Centaurea solstitialis Extract on Human Cancer Cell Lines","translated_title":"","metadata":{"publisher":"Galenos Yayinevi","grobid_abstract":"Bitkilerden elde edilen doğal ürünler, kanser dahil çeşitli hastalıkların tedavisinde uzun yıllardır kullanılmaktadır. Centaurea solstitialis subsp. solstitialis'in Türk geleneksel tıbbında yeri olduğu bilinmektedir. Bu araştırma, Muğla ilinden toplanan C. solstitialis'in çiçekli kısımlarından elde edilen etanolik özütün in vitro biyolojik etkilerini belirleyen ilk çalışmadır. Gereç ve Yöntemler: Özütün Daudi, A549 ve HeLa kanser hücrelerine ve normal BEAS-2B hücre hattına karşı sitotoksik etkisi MTT (3-(4,5dimetiltiyazol-2-il)-2,5-dipeniltetrazolyum bromür) testi ile belirlendi. Apoptotik hücre ölümü akış sitometri analizi ve kaspaz-3 aktivite deneyleriyle araştırıldı. Özüt ile muamele edilen hücreler tarafından üretilen anjiyojenik faktör [vasküler endotel büyüme faktörü (VEGF)] salınımı ve sitokinlerden interlökin (IL)-lα, IL-6 ve tümör nekroz faktör (TNF)-α'nın salınımı enzim bağlı immünosorbent deneyi testleriyle ölçüldü. Bulgular: Bitki özütü kullanılan tüm kanser hücre hatlarına karşı sitotoksik etki gösterirken, özüte karşı en duyarlı hücrelerin 63.18 µg/mL and 69.27 µg/mL olan IC 50 değerleri ile sırasıyla HeLa ve Daudi hücreleri olduğu gözlendi. Seçici sitotoksisite HeLa ve normal BEAS-2B hücre hatları arasında tespit edildi. Bitki özütü S ve G2 fazlarında hücre döngüsü arrestine yol açtı. Buna ilave olarak, HeLa ve A549 hücrelerinde apoptotik hücre ölümü kaydedildi. Ayrıca bitki özütü A549 hücrelerinin VEGF salgılamasında anlamlı bir düşüşe yol açarken, A549 ile Daudi hücrelerinin IL-lα, IL-6 ve TNF-α salgılamasında önemli değişime neden oldu. Sonuç: Bu bulgular kanser tedavisi ve sitokin salgısının modülasyonunda gerekli olan doğal ilaçların geliştirilmesi için C. solstitialis'in çiçekli kısımlarının potansiyel bir kaynak olabileceğini göstermektedir. Anahtar kelimeler: Centaurea solstitialis, kanser hücre hatları, anti-kanser, anti-inflamatuar Objectives: Natural products originating from plants have been used for many years in the treatment of various diseases, including cancer. Centaurea solstitialis subsp. solstitialis is used in Turkish folk medicine. This study was the first to determine the in vitro biological effects of ethanolic extract from the flowering parts of C. solstitialis L. subsp. solstitialis collected from Muğla Province. Materials and Methods: The cytotoxic effect was evaluated against Daudi, A549, and HeLa cancer cells and one normal BEAS-2B cell line using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-dipenyltetrazolium bromide) assay. Flow cytometric analysis and the caspase-3 activity assay were performed to detect apoptotic cell death. Angiogenic factor [vascular endothelial growth factor (VEGF)] secretion and the release of interleukin (IL)-1α, IL-6, and tumor necrosis factor (TNF)-α by cells treated with the extract were measured using enzyme-linked immunosorbent assay. Results: The extract exhibited cytotoxic effects against all the cancer cell lines used but HeLa and Daudi were the most sensitive cells, with IC 50 values of 63.18 µg/mL and 69.27 µg/mL, respectively. Selective cytotoxicity was observed between the HeLa and normal BEAS-2B cell lines. The extract arrested the cell cycle at the S and G2 phases. In addition, apoptotic cell death was detected in HeLa and A549 cells. Moreover, the plant extract caused a significant decrease in VEGF secretion in A549 cells and a fluctuation in IL-1α, IL-6, and TNF-α secretion in A549 and Daudi cells. Conclusion: These observations suggest that the flowering parts of C. solstitialis may be a potential source in the development of natural drugs for the treatment of cancer and modulation of cytokine secretion.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"Turkish Journal of Pharmaceutical Sciences","grobid_abstract_attachment_id":99969907},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686163/The_Anticancer_and_Anti_inflammatory_Effects_of_Centaurea_solstitialis_Extract_on_Human_Cancer_Cell_Lines","translated_internal_url":"","created_at":"2023-03-17T06:03:31.035-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969907,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969907/thumbnails/1.jpg","file_name":"TJPS-16-273-En.pdf","download_url":"https://www.academia.edu/attachments/99969907/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Anticancer_and_Anti_inflammatory_Eff.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969907/TJPS-16-273-En-libre.pdf?1679062089=\u0026response-content-disposition=attachment%3B+filename%3DThe_Anticancer_and_Anti_inflammatory_Eff.pdf\u0026Expires=1732984354\u0026Signature=HelQ~xMwP~j~tOOIoSy9vX0PFmXJHeXvtIJx68~bgABrF2VDuIFyqMWE5ZRfBijBrF7~klVJkZe1NnbMCDFNtQbNRHc0YjdrcYkbDUEzt8CsN~stQgU~nSBAApCIeoHWGaupjd7Xy6n7HhEi5fMqCwGuz5NLpZxKfWI6OnG0lV3DUvCt6G0u3~diOiZpZgIaHTj8IrU7a2uBX7rlXvDIGQ19RS49IsK2wbvD8YHo4IKlWhP8lP6WufkRh2XJ0MBvRLt1ymh~FvUTbDRKZ7cKBdKkaRbZQ2tx9Q2YSCOAA9zfvJM725y7T3aRb~l1rqWEKHuPC~maghnwJPhPaiP8GA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Anticancer_and_Anti_inflammatory_Effects_of_Centaurea_solstitialis_Extract_on_Human_Cancer_Cell_Lines","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969907,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969907/thumbnails/1.jpg","file_name":"TJPS-16-273-En.pdf","download_url":"https://www.academia.edu/attachments/99969907/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Anticancer_and_Anti_inflammatory_Eff.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969907/TJPS-16-273-En-libre.pdf?1679062089=\u0026response-content-disposition=attachment%3B+filename%3DThe_Anticancer_and_Anti_inflammatory_Eff.pdf\u0026Expires=1732984354\u0026Signature=HelQ~xMwP~j~tOOIoSy9vX0PFmXJHeXvtIJx68~bgABrF2VDuIFyqMWE5ZRfBijBrF7~klVJkZe1NnbMCDFNtQbNRHc0YjdrcYkbDUEzt8CsN~stQgU~nSBAApCIeoHWGaupjd7Xy6n7HhEi5fMqCwGuz5NLpZxKfWI6OnG0lV3DUvCt6G0u3~diOiZpZgIaHTj8IrU7a2uBX7rlXvDIGQ19RS49IsK2wbvD8YHo4IKlWhP8lP6WufkRh2XJ0MBvRLt1ymh~FvUTbDRKZ7cKBdKkaRbZQ2tx9Q2YSCOAA9zfvJM725y7T3aRb~l1rqWEKHuPC~maghnwJPhPaiP8GA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37782,"name":"Cell Culture","url":"https://www.academia.edu/Documents/in/Cell_Culture"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":608958,"name":"HeLa","url":"https://www.academia.edu/Documents/in/HeLa"},{"id":1490737,"name":"Secretion","url":"https://www.academia.edu/Documents/in/Secretion"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686162"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686162/Bioactivities_of_cry_gene_positive_Bacillus_thuringiensis_Berliner_Bacillales_Bacillaceae_strains_on_Ephestia_kuehniella_Zeller_1879_and_Plodia_interpunctella_H%C3%BCbner_1813_Lepidoptera_Pyralidae_"><img alt="Research paper thumbnail of Bioactivities of cry gene positive Bacillus thuringiensis (Berliner) (Bacillales: Bacillaceae) strains on Ephestia kuehniella Zeller, 1879 and Plodia interpunctella (Hübner, 1813) (Lepidoptera: Pyralidae)" class="work-thumbnail" src="https://attachments.academia-assets.com/99969906/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686162/Bioactivities_of_cry_gene_positive_Bacillus_thuringiensis_Berliner_Bacillales_Bacillaceae_strains_on_Ephestia_kuehniella_Zeller_1879_and_Plodia_interpunctella_H%C3%BCbner_1813_Lepidoptera_Pyralidae_">Bioactivities of cry gene positive Bacillus thuringiensis (Berliner) (Bacillales: Bacillaceae) strains on Ephestia kuehniella Zeller, 1879 and Plodia interpunctella (Hübner, 1813) (Lepidoptera: Pyralidae)</a></div><div class="wp-workCard_item"><span>Turkish Journal of Entomology</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6b00d760fdedf9d44104746ae005363c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969906,"asset_id":98686162,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969906/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686162"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686162"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686162; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686162]").text(description); $(".js-view-count[data-work-id=98686162]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686162; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686162']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686162, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6b00d760fdedf9d44104746ae005363c" } } $('.js-work-strip[data-work-id=98686162]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686162,"title":"Bioactivities of cry gene positive Bacillus thuringiensis (Berliner) (Bacillales: Bacillaceae) strains on Ephestia kuehniella Zeller, 1879 and Plodia interpunctella (Hübner, 1813) (Lepidoptera: Pyralidae)","translated_title":"","metadata":{"publisher":"Turkish Journal of Entomology","grobid_abstract":"Bioactivities of cry gene positive Bacillus thuringiensis (Berliner) (Bacillales: Bacillaceae) strains on Ephestia kuehniella Zeller, 1879 and Plodia interpunctella (Hübner, 1813) (Lepidoptera: Pyralidae) 1,2 cry gene pozitif Bacillus thuringiensis (Berliner) (Bacillales: Bacillaceae) izolatlarının","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Turkish Journal of Entomology","grobid_abstract_attachment_id":99969906},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686162/Bioactivities_of_cry_gene_positive_Bacillus_thuringiensis_Berliner_Bacillales_Bacillaceae_strains_on_Ephestia_kuehniella_Zeller_1879_and_Plodia_interpunctella_H%C3%BCbner_1813_Lepidoptera_Pyralidae_","translated_internal_url":"","created_at":"2023-03-17T06:03:30.916-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969906/thumbnails/1.jpg","file_name":"269962.pdf","download_url":"https://www.academia.edu/attachments/99969906/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bioactivities_of_cry_gene_positive_Bacil.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969906/269962-libre.pdf?1679062096=\u0026response-content-disposition=attachment%3B+filename%3DBioactivities_of_cry_gene_positive_Bacil.pdf\u0026Expires=1732984354\u0026Signature=Aq3IsWgYlOdi70Ei5LX~TRb8A0Vz-H~y~YNFcSxEbdaqLTTcNdLDvsmGJ4~UVbQKGFvgIOW~qBEzrh77ojU8f0qeCzPmdAaUEXAadCcU6WLphjnxJXLhgUfXLoeMaq6N0gVoMlQIB0EJBtRnCXCQiLj9mcVpst3SYvHocSB9o47TF2UoYzIs8ykR7nUREXaUjjet2WeNJPEHF8mxoBGaEDWHCJ0BLDktxu7fqUewpkc3ze0j8IqJCmdV6~Nj6YZmuttRRSBG59C2Bsg4GhPT6jPj4YubZDDHYnFyrey6vRq7gImoOaQzb~0JcXYffU9qMiHjU6IWZVNjZ03~IkYwig__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Bioactivities_of_cry_gene_positive_Bacillus_thuringiensis_Berliner_Bacillales_Bacillaceae_strains_on_Ephestia_kuehniella_Zeller_1879_and_Plodia_interpunctella_Hübner_1813_Lepidoptera_Pyralidae_","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969906/thumbnails/1.jpg","file_name":"269962.pdf","download_url":"https://www.academia.edu/attachments/99969906/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bioactivities_of_cry_gene_positive_Bacil.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969906/269962-libre.pdf?1679062096=\u0026response-content-disposition=attachment%3B+filename%3DBioactivities_of_cry_gene_positive_Bacil.pdf\u0026Expires=1732984354\u0026Signature=Aq3IsWgYlOdi70Ei5LX~TRb8A0Vz-H~y~YNFcSxEbdaqLTTcNdLDvsmGJ4~UVbQKGFvgIOW~qBEzrh77ojU8f0qeCzPmdAaUEXAadCcU6WLphjnxJXLhgUfXLoeMaq6N0gVoMlQIB0EJBtRnCXCQiLj9mcVpst3SYvHocSB9o47TF2UoYzIs8ykR7nUREXaUjjet2WeNJPEHF8mxoBGaEDWHCJ0BLDktxu7fqUewpkc3ze0j8IqJCmdV6~Nj6YZmuttRRSBG59C2Bsg4GhPT6jPj4YubZDDHYnFyrey6vRq7gImoOaQzb~0JcXYffU9qMiHjU6IWZVNjZ03~IkYwig__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":67768,"name":"Bacillus thuringiensis","url":"https://www.academia.edu/Documents/in/Bacillus_thuringiensis"},{"id":406914,"name":"Biopesticide","url":"https://www.academia.edu/Documents/in/Biopesticide"},{"id":1006629,"name":"Pyralidae","url":"https://www.academia.edu/Documents/in/Pyralidae"},{"id":3399686,"name":"plodia interpunctella","url":"https://www.academia.edu/Documents/in/plodia_interpunctella"},{"id":3586817,"name":"Bacillaceae","url":"https://www.academia.edu/Documents/in/Bacillaceae"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686161"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686161/Parasporins_as_a_natural_anti_cancer_protein"><img alt="Research paper thumbnail of Parasporins as a natural anti-cancer protein" class="work-thumbnail" src="https://attachments.academia-assets.com/99969902/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686161/Parasporins_as_a_natural_anti_cancer_protein">Parasporins as a natural anti-cancer protein</a></div><div class="wp-workCard_item"><span>ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="027e80d6a7804da2ad486e907e91a01c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969902,"asset_id":98686161,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969902/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686161"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686161"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686161; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686161]").text(description); $(".js-view-count[data-work-id=98686161]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686161; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686161']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686161, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "027e80d6a7804da2ad486e907e91a01c" } } $('.js-work-strip[data-work-id=98686161]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686161,"title":"Parasporins as a natural anti-cancer protein","translated_title":"","metadata":{"publisher":"Anadolu Universitesi Bilim ve Teknoloji Dergisi C : Yasam Bilimleri ve Biyoteknoloji","grobid_abstract":"Bacillus thuringiensis doğada geniş yayılım gösteren, gram pozitif ve spor oluşturan bir bakteridir. Sporulasyon evresinde, sporlarla birlikte birçok böcek çeşidine karşı insektisit etki gösteren kristal proteinleri de üretir. İnsektisidal kristal proteinler Cry ve Cyt proteinler olup; aktivitelerini duyarlı böceklerin orta barsak membranlarında bulunan reseptöre bağlanarak gösterirler. Bu reseptör bağlantılı özgül aktivitelerinden dolayı zirai mücadelede önemlidirler. Daha sonraları, insektisit olanlara göre doğada daha geniş dağılım gösteren insektisit olmayan kristal proteinler üzerindeki çalışmalar yeni bir protein sınıfı olan parasporinleri ortaya çıkarmıştır. Parasporinler ayrıcalıklı olarak kanser hücrelerine karşı sitotoksik etki gösterirken normal hücrelere etki etmez ve hemolitik etki göstermez. Şimdiye kadar altı parasporin ailesi tanımlanmış olup toplamda 19 alt grup bilinmektedir. Parasporinler de insektisidal kristal proteinlere benzer şekilde reseptör bağlantılı etki gösterdiğinden kanser tedavisiyle ilgili çalışmalarda yeni bir araştırma alanının ortaya çıkmasını sağlamıştır. Bu derlemede; parasporinlerin keşfi, özellikleri, çeşitleri ve etki mekanizmaları hakkında yapılmış olan çalışmalar özetle anlatılmıştır.","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology","grobid_abstract_attachment_id":99969902},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686161/Parasporins_as_a_natural_anti_cancer_protein","translated_internal_url":"","created_at":"2023-03-17T06:03:30.797-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969902,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969902/thumbnails/1.jpg","file_name":"338589.pdf","download_url":"https://www.academia.edu/attachments/99969902/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Parasporins_as_a_natural_anti_cancer_pro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969902/338589-libre.pdf?1679062093=\u0026response-content-disposition=attachment%3B+filename%3DParasporins_as_a_natural_anti_cancer_pro.pdf\u0026Expires=1732984354\u0026Signature=B3w1HTf8tsbfI2HFPId1hJruUtEV3iHSs0TKnHLrPEOyQXLsR8UDjogC5dBRamVayWx7Kj4O5O84hKYa7ZZ4nP7yA03lm0d8jMeg1OMtPK1M75PTMTiiVLmHBbSIXcigafkaDfz4fjxuFUbaV1DvRnuj2vsoKZM2BgyGq5iOAU6NLssV4bh6xcGtpJIi-UMsntpEQfmavBU-50ds2BqtV9iPDlQSpI4G0RxBuMs6kVz7nOkoJBPjjaewmoVYJ3S7Q2TbI9FVYFf1HRf~StwdowC8STQgvcy45ufU2q45TAS2OiXNyvApUooiSRxr88yfdGrOQ90b1y1B2116XvT79A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Parasporins_as_a_natural_anti_cancer_protein","translated_slug":"","page_count":11,"language":"tr","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969902,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969902/thumbnails/1.jpg","file_name":"338589.pdf","download_url":"https://www.academia.edu/attachments/99969902/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Parasporins_as_a_natural_anti_cancer_pro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969902/338589-libre.pdf?1679062093=\u0026response-content-disposition=attachment%3B+filename%3DParasporins_as_a_natural_anti_cancer_pro.pdf\u0026Expires=1732984354\u0026Signature=B3w1HTf8tsbfI2HFPId1hJruUtEV3iHSs0TKnHLrPEOyQXLsR8UDjogC5dBRamVayWx7Kj4O5O84hKYa7ZZ4nP7yA03lm0d8jMeg1OMtPK1M75PTMTiiVLmHBbSIXcigafkaDfz4fjxuFUbaV1DvRnuj2vsoKZM2BgyGq5iOAU6NLssV4bh6xcGtpJIi-UMsntpEQfmavBU-50ds2BqtV9iPDlQSpI4G0RxBuMs6kVz7nOkoJBPjjaewmoVYJ3S7Q2TbI9FVYFf1HRf~StwdowC8STQgvcy45ufU2q45TAS2OiXNyvApUooiSRxr88yfdGrOQ90b1y1B2116XvT79A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":1350274,"name":"Archaeology of Natural Places","url":"https://www.academia.edu/Documents/in/Archaeology_of_Natural_Places"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686160"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686160/Endemik_LathyrusT%C3%BCrlerinin_Antimikrobiyal_Ve_Antit%C3%BCm%C3%B6r_Aktiviteleri"><img alt="Research paper thumbnail of Endemik LathyrusTürlerinin Antimikrobiyal Ve Antitümör Aktiviteleri" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686160/Endemik_LathyrusT%C3%BCrlerinin_Antimikrobiyal_Ve_Antit%C3%BCm%C3%B6r_Aktiviteleri">Endemik LathyrusTürlerinin Antimikrobiyal Ve Antitümör Aktiviteleri</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686160"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686160"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686160; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686160]").text(description); $(".js-view-count[data-work-id=98686160]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686160; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686160']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686160, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686160]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686160,"title":"Endemik LathyrusTürlerinin Antimikrobiyal Ve Antitümör Aktiviteleri","translated_title":"","metadata":{},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686160/Endemik_LathyrusT%C3%BCrlerinin_Antimikrobiyal_Ve_Antit%C3%BCm%C3%B6r_Aktiviteleri","translated_internal_url":"","created_at":"2023-03-17T06:03:30.677-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Endemik_LathyrusTürlerinin_Antimikrobiyal_Ve_Antitümör_Aktiviteleri","translated_slug":"","page_count":null,"language":"tr","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686159"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686159/H_G%C3%BCne%C5%9F_M_Oktay_F_%C3%87elebi_B_T%C3%BCl_Screening_of_antimicrobial_and_anticancer_potentials_of_some_plant_extracts_from_Mugla_provience_Journal_of_Applied_Biological_Sciences_8_16_21_2014_"><img alt="Research paper thumbnail of H. Güneş, M. Oktay, F Çelebi, B Tül. Screening of antimicrobial and anticancer potentials of some plant extracts from Mugla provience. Journal of Applied Biological Sciences, 8: 16-21 (2014)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686159/H_G%C3%BCne%C5%9F_M_Oktay_F_%C3%87elebi_B_T%C3%BCl_Screening_of_antimicrobial_and_anticancer_potentials_of_some_plant_extracts_from_Mugla_provience_Journal_of_Applied_Biological_Sciences_8_16_21_2014_">H. Güneş, M. Oktay, F Çelebi, B Tül. Screening of antimicrobial and anticancer potentials of some plant extracts from Mugla provience. Journal of Applied Biological Sciences, 8: 16-21 (2014)</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686159"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686159"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686159; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686159]").text(description); $(".js-view-count[data-work-id=98686159]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686159; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686159']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686159, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686159]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686159,"title":"H. Güneş, M. Oktay, F Çelebi, B Tül. Screening of antimicrobial and anticancer potentials of some plant extracts from Mugla provience. Journal of Applied Biological Sciences, 8: 16-21 (2014)","translated_title":"","metadata":{},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686159/H_G%C3%BCne%C5%9F_M_Oktay_F_%C3%87elebi_B_T%C3%BCl_Screening_of_antimicrobial_and_anticancer_potentials_of_some_plant_extracts_from_Mugla_provience_Journal_of_Applied_Biological_Sciences_8_16_21_2014_","translated_internal_url":"","created_at":"2023-03-17T06:03:30.574-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"H_Güneş_M_Oktay_F_Çelebi_B_Tül_Screening_of_antimicrobial_and_anticancer_potentials_of_some_plant_extracts_from_Mugla_provience_Journal_of_Applied_Biological_Sciences_8_16_21_2014_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686158"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686158/Sitokinlerin_h%C3%BCcre_d%C3%B6ng%C3%BCs%C3%BC_%C3%BCzerinde_etkileri"><img alt="Research paper thumbnail of Sitokinlerin hücre döngüsü üzerinde etkileri" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686158/Sitokinlerin_h%C3%BCcre_d%C3%B6ng%C3%BCs%C3%BC_%C3%BCzerinde_etkileri">Sitokinlerin hücre döngüsü üzerinde etkileri</a></div><div class="wp-workCard_item"><span>Turkish Journal of Biology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ozet: Sitokinler hucresel duzenleyici proteinlerdir. Vucudun farkli dokularinda ceflitli hucreler...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ozet: Sitokinler hucresel duzenleyici proteinlerdir. Vucudun farkli dokularinda ceflitli hucreler tarafindan belli uyaricilara karfli salgilanip pek cok farkli biyolojik fonksiyonlari kontrol eden sitokinlerin en onemli etkilerinden biri hucre bolunmesi uzerindedir. Bazi sitokinler hucre dongusunun ilerlemesinde pozitif rol oynarken, bazilari hucre bolunmesini engelleyici etki gosterirler. Sitokinlerin hucre bolunmesi uzerindeki pozitif ve negatif etkileri hucre tipine bali olarak deiflir. Burada bazi sitokinlerin hucre dongusu uzerindeki etkilerinin molekuler mekanizmalari anlatilmifltir. Anahtar Sozcukler: Hucre Dongusu, Sitokinler, Buyume faktorleri, TGF-β. Effects of Cytokines on Cell Cycle Abstract: Cytokines are cellular regulatory proteins. They are secreted by specific cells, which are activated by certain stimuli, in different tissues. Cytokines control numerous biological functions and one of their important effects is on cell division. Although some of the cytokines have a positive effect on the cell cycle, some play a negative role. The positive and negative effects of cytokines depend upon the cell type. In this paper, the moleculer mechanisms of cytokine effects on the cell cycle are examined.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686158"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686158"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686158; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686158]").text(description); $(".js-view-count[data-work-id=98686158]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686158; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686158']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686158, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686158]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686158,"title":"Sitokinlerin hücre döngüsü üzerinde etkileri","translated_title":"","metadata":{"abstract":"Ozet: Sitokinler hucresel duzenleyici proteinlerdir. Vucudun farkli dokularinda ceflitli hucreler tarafindan belli uyaricilara karfli salgilanip pek cok farkli biyolojik fonksiyonlari kontrol eden sitokinlerin en onemli etkilerinden biri hucre bolunmesi uzerindedir. Bazi sitokinler hucre dongusunun ilerlemesinde pozitif rol oynarken, bazilari hucre bolunmesini engelleyici etki gosterirler. Sitokinlerin hucre bolunmesi uzerindeki pozitif ve negatif etkileri hucre tipine bali olarak deiflir. Burada bazi sitokinlerin hucre dongusu uzerindeki etkilerinin molekuler mekanizmalari anlatilmifltir. Anahtar Sozcukler: Hucre Dongusu, Sitokinler, Buyume faktorleri, TGF-β. Effects of Cytokines on Cell Cycle Abstract: Cytokines are cellular regulatory proteins. They are secreted by specific cells, which are activated by certain stimuli, in different tissues. Cytokines control numerous biological functions and one of their important effects is on cell division. Although some of the cytokines have a positive effect on the cell cycle, some play a negative role. The positive and negative effects of cytokines depend upon the cell type. In this paper, the moleculer mechanisms of cytokine effects on the cell cycle are examined.","publication_name":"Turkish Journal of Biology"},"translated_abstract":"Ozet: Sitokinler hucresel duzenleyici proteinlerdir. Vucudun farkli dokularinda ceflitli hucreler tarafindan belli uyaricilara karfli salgilanip pek cok farkli biyolojik fonksiyonlari kontrol eden sitokinlerin en onemli etkilerinden biri hucre bolunmesi uzerindedir. Bazi sitokinler hucre dongusunun ilerlemesinde pozitif rol oynarken, bazilari hucre bolunmesini engelleyici etki gosterirler. Sitokinlerin hucre bolunmesi uzerindeki pozitif ve negatif etkileri hucre tipine bali olarak deiflir. Burada bazi sitokinlerin hucre dongusu uzerindeki etkilerinin molekuler mekanizmalari anlatilmifltir. Anahtar Sozcukler: Hucre Dongusu, Sitokinler, Buyume faktorleri, TGF-β. Effects of Cytokines on Cell Cycle Abstract: Cytokines are cellular regulatory proteins. They are secreted by specific cells, which are activated by certain stimuli, in different tissues. Cytokines control numerous biological functions and one of their important effects is on cell division. Although some of the cytokines have a positive effect on the cell cycle, some play a negative role. The positive and negative effects of cytokines depend upon the cell type. In this paper, the moleculer mechanisms of cytokine effects on the cell cycle are examined.","internal_url":"https://www.academia.edu/98686158/Sitokinlerin_h%C3%BCcre_d%C3%B6ng%C3%BCs%C3%BC_%C3%BCzerinde_etkileri","translated_internal_url":"","created_at":"2023-03-17T06:03:30.467-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Sitokinlerin_hücre_döngüsü_üzerinde_etkileri","translated_slug":"","page_count":null,"language":"tr","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686157"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686157/Celenk_yay%C4%B1n_PDF_formu_2008"><img alt="Research paper thumbnail of Celenk yayın PDF formu 2008" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686157/Celenk_yay%C4%B1n_PDF_formu_2008">Celenk yayın PDF formu 2008</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686157"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686157"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686157; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686157]").text(description); $(".js-view-count[data-work-id=98686157]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686157; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686157']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686157, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686157]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686157,"title":"Celenk yayın PDF formu 2008","translated_title":"","metadata":{},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686157/Celenk_yay%C4%B1n_PDF_formu_2008","translated_internal_url":"","created_at":"2023-03-17T06:03:30.359-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Celenk_yayın_PDF_formu_2008","translated_slug":"","page_count":null,"language":"tr","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686156"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686156/H746635193663U36_BTpaper_Apayd%C4%B1n_O"><img alt="Research paper thumbnail of H746635193663U36 (BTpaper Apaydın O" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686156/H746635193663U36_BTpaper_Apayd%C4%B1n_O">H746635193663U36 (BTpaper Apaydın O</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686156"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686156"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686156; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686156]").text(description); $(".js-view-count[data-work-id=98686156]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686156; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686156']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686156, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686156]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686156,"title":"H746635193663U36 (BTpaper Apaydın O","translated_title":"","metadata":{},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686156/H746635193663U36_BTpaper_Apayd%C4%B1n_O","translated_internal_url":"","created_at":"2023-03-17T06:03:30.247-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"H746635193663U36_BTpaper_Apaydın_O","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686155"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686155/The_expression_of_forms_of_prolactin_receptors_in_splenocytes_and_thymocytes_of_neonatal_rats_the_effect_of_milk_ingestion"><img alt="Research paper thumbnail of The expression of forms of prolactin receptors in splenocytes and thymocytes of neonatal rats: the effect of milk ingestion" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686155/The_expression_of_forms_of_prolactin_receptors_in_splenocytes_and_thymocytes_of_neonatal_rats_the_effect_of_milk_ingestion">The expression of forms of prolactin receptors in splenocytes and thymocytes of neonatal rats: the effect of milk ingestion</a></div><div class="wp-workCard_item"><span>Endocrine regulations</span><span>, 1993</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Because prolactin (PRL) plays a role in neonatal immune development, we examined the expression o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Because prolactin (PRL) plays a role in neonatal immune development, we examined the expression of prolactin receptors (PRL-R) in neonatal lymphoid tissues. We had shown previously that deprivation of milk-borne PRL, days 2-5 in the neonatal rat, leads to enhanced in vitro mitogenesis of thymocytes and splenocytes as well as a change in lymphoid-specific, cell surface antigens (GROVE et al. 1991). In this present study, we asked if neonatal lymphocytes express PRL-R; which forms of PRL-R are expressed (long vs. short form); when these forms are expressed during development; and if milk ingestion plays a role in receptor expression. Two approaches were taken using neonatal rat thymocytes and splenocytes: RNA was analyzed by polymerase chain reaction (PCR) and cells were stained with antibody to PRL-R and analyzed by flow cytometry. In regard to cell surface expression, the percentage of PRL-R positive splenocytes was greater than thymocytes at all ages tested. In the spleen, the perc...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686155"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686155"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686155; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686155]").text(description); $(".js-view-count[data-work-id=98686155]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686155; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686155']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686155, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=98686155]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686155,"title":"The expression of forms of prolactin receptors in splenocytes and thymocytes of neonatal rats: the effect of milk ingestion","translated_title":"","metadata":{"abstract":"Because prolactin (PRL) plays a role in neonatal immune development, we examined the expression of prolactin receptors (PRL-R) in neonatal lymphoid tissues. We had shown previously that deprivation of milk-borne PRL, days 2-5 in the neonatal rat, leads to enhanced in vitro mitogenesis of thymocytes and splenocytes as well as a change in lymphoid-specific, cell surface antigens (GROVE et al. 1991). In this present study, we asked if neonatal lymphocytes express PRL-R; which forms of PRL-R are expressed (long vs. short form); when these forms are expressed during development; and if milk ingestion plays a role in receptor expression. Two approaches were taken using neonatal rat thymocytes and splenocytes: RNA was analyzed by polymerase chain reaction (PCR) and cells were stained with antibody to PRL-R and analyzed by flow cytometry. In regard to cell surface expression, the percentage of PRL-R positive splenocytes was greater than thymocytes at all ages tested. In the spleen, the perc...","publication_date":{"day":null,"month":null,"year":1993,"errors":{}},"publication_name":"Endocrine regulations"},"translated_abstract":"Because prolactin (PRL) plays a role in neonatal immune development, we examined the expression of prolactin receptors (PRL-R) in neonatal lymphoid tissues. We had shown previously that deprivation of milk-borne PRL, days 2-5 in the neonatal rat, leads to enhanced in vitro mitogenesis of thymocytes and splenocytes as well as a change in lymphoid-specific, cell surface antigens (GROVE et al. 1991). In this present study, we asked if neonatal lymphocytes express PRL-R; which forms of PRL-R are expressed (long vs. short form); when these forms are expressed during development; and if milk ingestion plays a role in receptor expression. Two approaches were taken using neonatal rat thymocytes and splenocytes: RNA was analyzed by polymerase chain reaction (PCR) and cells were stained with antibody to PRL-R and analyzed by flow cytometry. In regard to cell surface expression, the percentage of PRL-R positive splenocytes was greater than thymocytes at all ages tested. In the spleen, the perc...","internal_url":"https://www.academia.edu/98686155/The_expression_of_forms_of_prolactin_receptors_in_splenocytes_and_thymocytes_of_neonatal_rats_the_effect_of_milk_ingestion","translated_internal_url":"","created_at":"2023-03-17T06:03:30.132-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_expression_of_forms_of_prolactin_receptors_in_splenocytes_and_thymocytes_of_neonatal_rats_the_effect_of_milk_ingestion","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":64657,"name":"Prolactin","url":"https://www.academia.edu/Documents/in/Prolactin"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction"},{"id":238368,"name":"Milk","url":"https://www.academia.edu/Documents/in/Milk"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":396894,"name":"Ingestion","url":"https://www.academia.edu/Documents/in/Ingestion"},{"id":555007,"name":"Receptor","url":"https://www.academia.edu/Documents/in/Receptor"},{"id":809882,"name":"Base Sequence","url":"https://www.academia.edu/Documents/in/Base_Sequence"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data"},{"id":3881526,"name":"In Vitro Techniques","url":"https://www.academia.edu/Documents/in/In_Vitro_Techniques"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686154"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686154/Distribution_occurrence_of_cry_genes_and_lepidopteran_toxicity_of_native_Bacillus_thuringiensis_isolated_from_fig_tree_environments_in_Ayd%C4%B1n_Province"><img alt="Research paper thumbnail of Distribution, occurrence of cry genes, and lepidopteran toxicity of native Bacillus thuringiensis isolated from fig tree environments in Aydın Province" class="work-thumbnail" src="https://attachments.academia-assets.com/99969900/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686154/Distribution_occurrence_of_cry_genes_and_lepidopteran_toxicity_of_native_Bacillus_thuringiensis_isolated_from_fig_tree_environments_in_Ayd%C4%B1n_Province">Distribution, occurrence of cry genes, and lepidopteran toxicity of native Bacillus thuringiensis isolated from fig tree environments in Aydın Province</a></div><div class="wp-workCard_item"><span>TURKISH JOURNAL OF AGRICULTURE AND FORESTRY</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2a8d3acdc28a6b750caeed0df1661961" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969900,"asset_id":98686154,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969900/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686154"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686154"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686154; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686154]").text(description); $(".js-view-count[data-work-id=98686154]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686154; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686154']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686154, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2a8d3acdc28a6b750caeed0df1661961" } } $('.js-work-strip[data-work-id=98686154]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686154,"title":"Distribution, occurrence of cry genes, and lepidopteran toxicity of native Bacillus thuringiensis isolated from fig tree environments in Aydın Province","translated_title":"","metadata":{"publisher":"The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS","grobid_abstract":"Bacillus thuringiensis (Bt) has a significant impact on biological pest control because of the insecticidal activity through its parasporal inclusion bodies (crystal proteins). Fig is an economically important plant in Turkey; agricultural pests result in a considerable economic loss in fig quality and cultivation. The aim of this work was to isolate, characterize, and determine the lepidopteran toxicity of Bt obtained from fig groves in Aydın Province. A total of 606 colonies (out of 1167) obtained from 380 samples were identified as Bt based on parasporal crystal formation. The highest Bt index of 0.60 was observed in the Kuyucak region. A total of 288 Bt isolates were characterized in terms of cry gene content by PCR analysis. It was found that the cry1 plus cry2 genotype was the most abundant (40%) in our collection. Bioactivity tests indicated that 6 isolates exhibited high mortalities against Cadra cautella and 3 isolates were found to exhibit high toxicity against Carpophilus hemipterus. Moreover, 13 Bt isolates exhibiting toxic activity against fig pests were further characterized based on specific cry gene content, protein profiles, and PCR-RFLP analysis. Among cry1 genes, the cry1Aa, cry1Ab, cry1Ac, cry1B, cry1C, cry1D, and cry1Ea genes were the most frequent (100%). Protein profiles of isolates toxic to C. cautella were different from those of isolates toxic to C. hemipterus. PCR-RFLP analysis indicated that toxic isolates differed from the reference strain with respect to cry1 type gene. Finally, it was concluded that Bt strains isolated from fig groves showed high level of toxicity against fig pests. These strains can serve as potential biopesticides for the control of C. cautella in the region as well as alternative biopesticides in the case of pesticide resistance in insects.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"TURKISH JOURNAL OF AGRICULTURE AND FORESTRY","grobid_abstract_attachment_id":99969900},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686154/Distribution_occurrence_of_cry_genes_and_lepidopteran_toxicity_of_native_Bacillus_thuringiensis_isolated_from_fig_tree_environments_in_Ayd%C4%B1n_Province","translated_internal_url":"","created_at":"2023-03-17T06:03:30.010-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969900,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969900/thumbnails/1.jpg","file_name":"78fa301f0453d9e6a13830ec77a39b6dd864.pdf","download_url":"https://www.academia.edu/attachments/99969900/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Distribution_occurrence_of_cry_genes_and.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969900/78fa301f0453d9e6a13830ec77a39b6dd864-libre.pdf?1679062084=\u0026response-content-disposition=attachment%3B+filename%3DDistribution_occurrence_of_cry_genes_and.pdf\u0026Expires=1732984354\u0026Signature=ANPr2gWkr0AJpsrGGZFIBGF4X1TR7Y9TWdLRfdPr6tSiNzA3aLD9tZjjyxg3DBjN-We1hoLvcIzDKsZsS-DFRmiv0QbSuyayCTxIrbfVfVms4ssrcPBqRXfcq8GI8jikvUa~rzFmvL4-rcS2nKbXwJIGfzw7IanPGnzJCvQVkyuYL5~s3pfPnSrDdtLdi2bYyqWupllnrJ3JZYqMiJnIvBB389T7giMT7FQh9rhYhGMNg2Xm5mIxFsgQAfGg9n-Q4nOZYXWpcxyWDHsPt4PvaZodlVApIugQB5BZfmji9H94eu1IytWWWUUdeXB8cS-uRchRw5-lf01WQIjL7eoatQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Distribution_occurrence_of_cry_genes_and_lepidopteran_toxicity_of_native_Bacillus_thuringiensis_isolated_from_fig_tree_environments_in_Aydın_Province","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969900,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969900/thumbnails/1.jpg","file_name":"78fa301f0453d9e6a13830ec77a39b6dd864.pdf","download_url":"https://www.academia.edu/attachments/99969900/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Distribution_occurrence_of_cry_genes_and.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969900/78fa301f0453d9e6a13830ec77a39b6dd864-libre.pdf?1679062084=\u0026response-content-disposition=attachment%3B+filename%3DDistribution_occurrence_of_cry_genes_and.pdf\u0026Expires=1732984354\u0026Signature=ANPr2gWkr0AJpsrGGZFIBGF4X1TR7Y9TWdLRfdPr6tSiNzA3aLD9tZjjyxg3DBjN-We1hoLvcIzDKsZsS-DFRmiv0QbSuyayCTxIrbfVfVms4ssrcPBqRXfcq8GI8jikvUa~rzFmvL4-rcS2nKbXwJIGfzw7IanPGnzJCvQVkyuYL5~s3pfPnSrDdtLdi2bYyqWupllnrJ3JZYqMiJnIvBB389T7giMT7FQh9rhYhGMNg2Xm5mIxFsgQAfGg9n-Q4nOZYXWpcxyWDHsPt4PvaZodlVApIugQB5BZfmji9H94eu1IytWWWUUdeXB8cS-uRchRw5-lf01WQIjL7eoatQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":67768,"name":"Bacillus thuringiensis","url":"https://www.academia.edu/Documents/in/Bacillus_thuringiensis"},{"id":181936,"name":"Gene","url":"https://www.academia.edu/Documents/in/Gene"},{"id":988766,"name":"Bioactivity","url":"https://www.academia.edu/Documents/in/Bioactivity"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686153"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686153/RFLP_of_16S_ITSrDNA_Region_to_Differentiate_Lactobacilli_at_Species_Level"><img alt="Research paper thumbnail of RFLP of 16S-ITSrDNA Region to Differentiate Lactobacilli at Species Level" class="work-thumbnail" src="https://attachments.academia-assets.com/99969908/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686153/RFLP_of_16S_ITSrDNA_Region_to_Differentiate_Lactobacilli_at_Species_Level">RFLP of 16S-ITSrDNA Region to Differentiate Lactobacilli at Species Level</a></div><div class="wp-workCard_item"><span>World Journal of Microbiology and Biotechnology</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f670f082db0832c0a569888bf855ce81" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969908,"asset_id":98686153,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969908/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686153"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686153"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686153; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686153]").text(description); $(".js-view-count[data-work-id=98686153]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686153; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686153']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686153, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f670f082db0832c0a569888bf855ce81" } } $('.js-work-strip[data-work-id=98686153]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686153,"title":"RFLP of 16S-ITSrDNA Region to Differentiate Lactobacilli at Species Level","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","grobid_abstract":"The 16S-ITS (internal transcribed spacer) region of the rrn operon was amplified by polymerase chain reaction (PCR). The amplification products were analysed by restriction fragment length polymorphism (RFLP) using a set of restriction enzymes, AluI, HaeIII, and TaqI. Restriction pattern analyses revealed that TaqI restriction enzyme could clearly differentiate the nine reference strains of Lactobacillus used in the study.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"World Journal of Microbiology and Biotechnology","grobid_abstract_attachment_id":99969908},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686153/RFLP_of_16S_ITSrDNA_Region_to_Differentiate_Lactobacilli_at_Species_Level","translated_internal_url":"","created_at":"2023-03-17T06:03:29.886-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969908,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969908/thumbnails/1.jpg","file_name":"4728.pdf","download_url":"https://www.academia.edu/attachments/99969908/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"RFLP_of_16S_ITSrDNA_Region_to_Differenti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969908/4728-libre.pdf?1679062075=\u0026response-content-disposition=attachment%3B+filename%3DRFLP_of_16S_ITSrDNA_Region_to_Differenti.pdf\u0026Expires=1732984354\u0026Signature=QR7D1GqHp3QCReEV553QUqQdnjltM6tksIOoyGswuOiF3uR2RFZp-zfLNXqj7eBNGXMCe8jU2mOHe4wRBQ37uXZWw5ebw6TpgBUwcn6Zf0vmvkmePtVIAGCXYVqHQ~DNU5R9kJj-kSg4qyvd-9NXyWTaDKCP4hgpQIhxn-IVt0xvxc1fpGGaalOA1ulwLpntmKzgzJUd80ldk~N3HZ3tDBw9hwn2Pd34vLz8oaCRyaKG2983~0kplocpbE01~oEvp3bG8-g7uLUMT8G5LYvhTqBZ2spXtx9SbLN91gj-K8yRFDzmDYImQQzj~EgDUThaibrASDEV4l3RT7aGOBVhDA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"RFLP_of_16S_ITSrDNA_Region_to_Differentiate_Lactobacilli_at_Species_Level","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969908,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969908/thumbnails/1.jpg","file_name":"4728.pdf","download_url":"https://www.academia.edu/attachments/99969908/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"RFLP_of_16S_ITSrDNA_Region_to_Differenti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969908/4728-libre.pdf?1679062075=\u0026response-content-disposition=attachment%3B+filename%3DRFLP_of_16S_ITSrDNA_Region_to_Differenti.pdf\u0026Expires=1732984354\u0026Signature=QR7D1GqHp3QCReEV553QUqQdnjltM6tksIOoyGswuOiF3uR2RFZp-zfLNXqj7eBNGXMCe8jU2mOHe4wRBQ37uXZWw5ebw6TpgBUwcn6Zf0vmvkmePtVIAGCXYVqHQ~DNU5R9kJj-kSg4qyvd-9NXyWTaDKCP4hgpQIhxn-IVt0xvxc1fpGGaalOA1ulwLpntmKzgzJUd80ldk~N3HZ3tDBw9hwn2Pd34vLz8oaCRyaKG2983~0kplocpbE01~oEvp3bG8-g7uLUMT8G5LYvhTqBZ2spXtx9SbLN91gj-K8yRFDzmDYImQQzj~EgDUThaibrASDEV4l3RT7aGOBVhDA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":923,"name":"Technology","url":"https://www.academia.edu/Documents/in/Technology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":73606,"name":"World","url":"https://www.academia.edu/Documents/in/World"},{"id":74144,"name":"Lactic Acid Bacteria","url":"https://www.academia.edu/Documents/in/Lactic_Acid_Bacteria"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction"},{"id":2579012,"name":"restriction enzyme","url":"https://www.academia.edu/Documents/in/restriction_enzyme"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686152"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686152/Prolactin_and_The_Development_of_The_Neonatal_Immune_System"><img alt="Research paper thumbnail of Prolactin and The Development of The Neonatal Immune System" class="work-thumbnail" src="https://attachments.academia-assets.com/99969903/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686152/Prolactin_and_The_Development_of_The_Neonatal_Immune_System">Prolactin and The Development of The Neonatal Immune System</a></div><div class="wp-workCard_item"><span>Pediatric Research</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0985a2c694b4607f124d0e354bd2d775" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969903,"asset_id":98686152,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969903/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686152"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686152"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686152; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686152]").text(description); $(".js-view-count[data-work-id=98686152]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686152; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686152']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686152, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0985a2c694b4607f124d0e354bd2d775" } } $('.js-work-strip[data-work-id=98686152]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686152,"title":"Prolactin and The Development of The Neonatal Immune System","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Pediatric Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686152/Prolactin_and_The_Development_of_The_Neonatal_Immune_System","translated_internal_url":"","created_at":"2023-03-17T06:03:29.765-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969903,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969903/thumbnails/1.jpg","file_name":"pr19992273.pdf","download_url":"https://www.academia.edu/attachments/99969903/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prolactin_and_The_Development_of_The_Neo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969903/pr19992273-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DProlactin_and_The_Development_of_The_Neo.pdf\u0026Expires=1732984354\u0026Signature=GurqkQxjVAM8h2uORjZPClqfzUgchkJOA2qkZWEOWznsf1JzR8a2X-DVzb8D~5qsvUTc~HkvhKBOxVnvC5bHQCT6oQdt2NdV5BYxwejFYk~He-pkfNJP3U9Xw8tJgrP36Q01oHt-eI9KWYQkgQpl-JHBNYSyI~KBo-FuAzFAEDfBZqgEqb5OPNSWTDtb5nM5MHEs9c2~cYcpjypUGdwRBq6-GYzVmzWUrW-~rS0bcQBeHxUF3WBbHMEL1CDiMBcKcG55rwqpBnyBdrIDJZ8JZU8-J~JN3t0rEZicXCamx6MAU2LiRXbbqjRmvZnM1Zg07d1w6nYXzwAuVj46TRxU8g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Prolactin_and_The_Development_of_The_Neonatal_Immune_System","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969903,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969903/thumbnails/1.jpg","file_name":"pr19992273.pdf","download_url":"https://www.academia.edu/attachments/99969903/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prolactin_and_The_Development_of_The_Neo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969903/pr19992273-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DProlactin_and_The_Development_of_The_Neo.pdf\u0026Expires=1732984354\u0026Signature=GurqkQxjVAM8h2uORjZPClqfzUgchkJOA2qkZWEOWznsf1JzR8a2X-DVzb8D~5qsvUTc~HkvhKBOxVnvC5bHQCT6oQdt2NdV5BYxwejFYk~He-pkfNJP3U9Xw8tJgrP36Q01oHt-eI9KWYQkgQpl-JHBNYSyI~KBo-FuAzFAEDfBZqgEqb5OPNSWTDtb5nM5MHEs9c2~cYcpjypUGdwRBq6-GYzVmzWUrW-~rS0bcQBeHxUF3WBbHMEL1CDiMBcKcG55rwqpBnyBdrIDJZ8JZU8-J~JN3t0rEZicXCamx6MAU2LiRXbbqjRmvZnM1Zg07d1w6nYXzwAuVj46TRxU8g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":64657,"name":"Prolactin","url":"https://www.academia.edu/Documents/in/Prolactin"},{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686151"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686151/Homofermentative_lactic_acid_bacteria_of_a_traditional_cheese_Comlek_peyniri_from_Cappadocia_region"><img alt="Research paper thumbnail of Homofermentative lactic acid bacteria of a traditional cheese, Comlek peyniri from Cappadocia region" class="work-thumbnail" src="https://attachments.academia-assets.com/99969912/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686151/Homofermentative_lactic_acid_bacteria_of_a_traditional_cheese_Comlek_peyniri_from_Cappadocia_region">Homofermentative lactic acid bacteria of a traditional cheese, Comlek peyniri from Cappadocia region</a></div><div class="wp-workCard_item"><span>Journal of Dairy Research</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Comlek peyniri is a typical artisanal cheese in Central Anatolia. This type of cheese was made by...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Comlek peyniri is a typical artisanal cheese in Central Anatolia. This type of cheese was made by using the indigenous lactic acid bacteria (LAB) flora of cow or ewes&#39; milk. Majority of the samples were taken from fresh cheese because the aim was to isolate homofermentative LAB. Initially 661 microbial isolates were obtained from 17 cheese samples. Only 107 were found to be homofermentative LAB. These isolates were selected and identified by using both phenotypic and molecular methods. Phenotypic identification included curd formation from skim milk, catalase test, Gram staining and light microscopy, growth at different temperatures and salt concentrations, arginine hydrolysis, gas production from glucose, and carbohydrate fermentation. Molecular identification was based on the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of the 16S rRNA gene-ITS (internally transcribed spacer) region. By combining the phenotypic and molecular identification resu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4d0807b21fbda91875ecac7c5dae9587" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969912,"asset_id":98686151,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969912/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686151"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686151"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686151; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686151]").text(description); $(".js-view-count[data-work-id=98686151]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686151; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686151']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686151, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4d0807b21fbda91875ecac7c5dae9587" } } $('.js-work-strip[data-work-id=98686151]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686151,"title":"Homofermentative lactic acid bacteria of a traditional cheese, Comlek peyniri from Cappadocia region","translated_title":"","metadata":{"abstract":"Comlek peyniri is a typical artisanal cheese in Central Anatolia. This type of cheese was made by using the indigenous lactic acid bacteria (LAB) flora of cow or ewes\u0026#39; milk. Majority of the samples were taken from fresh cheese because the aim was to isolate homofermentative LAB. Initially 661 microbial isolates were obtained from 17 cheese samples. Only 107 were found to be homofermentative LAB. These isolates were selected and identified by using both phenotypic and molecular methods. Phenotypic identification included curd formation from skim milk, catalase test, Gram staining and light microscopy, growth at different temperatures and salt concentrations, arginine hydrolysis, gas production from glucose, and carbohydrate fermentation. Molecular identification was based on the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of the 16S rRNA gene-ITS (internally transcribed spacer) region. By combining the phenotypic and molecular identification resu...","publisher":"Cambridge University Press (CUP)","publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Journal of Dairy Research"},"translated_abstract":"Comlek peyniri is a typical artisanal cheese in Central Anatolia. This type of cheese was made by using the indigenous lactic acid bacteria (LAB) flora of cow or ewes\u0026#39; milk. Majority of the samples were taken from fresh cheese because the aim was to isolate homofermentative LAB. Initially 661 microbial isolates were obtained from 17 cheese samples. Only 107 were found to be homofermentative LAB. These isolates were selected and identified by using both phenotypic and molecular methods. Phenotypic identification included curd formation from skim milk, catalase test, Gram staining and light microscopy, growth at different temperatures and salt concentrations, arginine hydrolysis, gas production from glucose, and carbohydrate fermentation. Molecular identification was based on the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of the 16S rRNA gene-ITS (internally transcribed spacer) region. By combining the phenotypic and molecular identification resu...","internal_url":"https://www.academia.edu/98686151/Homofermentative_lactic_acid_bacteria_of_a_traditional_cheese_Comlek_peyniri_from_Cappadocia_region","translated_internal_url":"","created_at":"2023-03-17T06:03:29.584-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969912,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969912/thumbnails/1.jpg","file_name":"7070fcddfb9152d9aaebff67a6a437ee95dc.pdf","download_url":"https://www.academia.edu/attachments/99969912/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Homofermentative_lactic_acid_bacteria_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969912/7070fcddfb9152d9aaebff67a6a437ee95dc-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DHomofermentative_lactic_acid_bacteria_of.pdf\u0026Expires=1732984354\u0026Signature=BVTMuWAVZrZg3dzE2oglN6a0fhcVtAnqKwmu~XUOGBz-Ry2fUxzAgTAM0HupK~KpBDhJ~qOziz01Yh7JQmRai7gW~mwxQ3WyEugb4XDKU8RXarrKVqyhEVSk0PftK4~o9I75B0xBP4gtof7BWLCR0EKv7e0jj-GoCqaH85sWBFBf9mGVNiCQGbyOP7D3pybT9RzO-WuGDOd1cLnOO4Drgqf~vjvq6nM6jdubXHjsfdEgMenirTt8k3UECqAI3qE56YMr-EbIiYmixl9-k6LhZJvmWn6qf~JM5hoOtypfs0dQW5vdk2go7DW9FiwE18lg2WY4KguafH9SNDcR1mNieQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Homofermentative_lactic_acid_bacteria_of_a_traditional_cheese_Comlek_peyniri_from_Cappadocia_region","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969912,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969912/thumbnails/1.jpg","file_name":"7070fcddfb9152d9aaebff67a6a437ee95dc.pdf","download_url":"https://www.academia.edu/attachments/99969912/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Homofermentative_lactic_acid_bacteria_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969912/7070fcddfb9152d9aaebff67a6a437ee95dc-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DHomofermentative_lactic_acid_bacteria_of.pdf\u0026Expires=1732984354\u0026Signature=BVTMuWAVZrZg3dzE2oglN6a0fhcVtAnqKwmu~XUOGBz-Ry2fUxzAgTAM0HupK~KpBDhJ~qOziz01Yh7JQmRai7gW~mwxQ3WyEugb4XDKU8RXarrKVqyhEVSk0PftK4~o9I75B0xBP4gtof7BWLCR0EKv7e0jj-GoCqaH85sWBFBf9mGVNiCQGbyOP7D3pybT9RzO-WuGDOd1cLnOO4Drgqf~vjvq6nM6jdubXHjsfdEgMenirTt8k3UECqAI3qE56YMr-EbIiYmixl9-k6LhZJvmWn6qf~JM5hoOtypfs0dQW5vdk2go7DW9FiwE18lg2WY4KguafH9SNDcR1mNieQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1040,"name":"Food Science","url":"https://www.academia.edu/Documents/in/Food_Science"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":10966,"name":"Turkey","url":"https://www.academia.edu/Documents/in/Turkey"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29980,"name":"Animal Production","url":"https://www.academia.edu/Documents/in/Animal_Production"},{"id":63353,"name":"Identification","url":"https://www.academia.edu/Documents/in/Identification"},{"id":74144,"name":"Lactic Acid Bacteria","url":"https://www.academia.edu/Documents/in/Lactic_Acid_Bacteria"},{"id":113903,"name":"Bacteria","url":"https://www.academia.edu/Documents/in/Bacteria"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction"},{"id":181926,"name":"Dairy","url":"https://www.academia.edu/Documents/in/Dairy"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":238368,"name":"Milk","url":"https://www.academia.edu/Documents/in/Milk"},{"id":251661,"name":"Cheese","url":"https://www.academia.edu/Documents/in/Cheese"},{"id":269129,"name":"Fermentation","url":"https://www.academia.edu/Documents/in/Fermentation"},{"id":427784,"name":"Enterococcus","url":"https://www.academia.edu/Documents/in/Enterococcus"},{"id":573653,"name":"Food Sciences","url":"https://www.academia.edu/Documents/in/Food_Sciences"},{"id":599635,"name":"Cambridge University","url":"https://www.academia.edu/Documents/in/Cambridge_University"},{"id":1074508,"name":"Lactic Acid","url":"https://www.academia.edu/Documents/in/Lactic_Acid"},{"id":1242119,"name":"Lactococcus lactis","url":"https://www.academia.edu/Documents/in/Lactococcus_lactis"}],"urls":[{"id":29866545,"url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0022029904000536"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686150"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686150/Identification_of_extracellular_enzyme_producing_thermophilic_bacilli_from_Balcova_Agamemnon_geothermal_site_by_ITS_rDNA_RFLP"><img alt="Research paper thumbnail of Identification of extracellular enzyme producing thermophilic bacilli from Balcova (Agamemnon) geothermal site by ITS rDNA RFLP" class="work-thumbnail" src="https://attachments.academia-assets.com/99969917/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686150/Identification_of_extracellular_enzyme_producing_thermophilic_bacilli_from_Balcova_Agamemnon_geothermal_site_by_ITS_rDNA_RFLP">Identification of extracellular enzyme producing thermophilic bacilli from Balcova (Agamemnon) geothermal site by ITS rDNA RFLP</a></div><div class="wp-workCard_item"><span>Journal of Applied Microbiology</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="02f692257f1c21939ab81a84ae6fcb38" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969917,"asset_id":98686150,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969917/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686150"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686150"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686150; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686150]").text(description); $(".js-view-count[data-work-id=98686150]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686150; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686150']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686150, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "02f692257f1c21939ab81a84ae6fcb38" } } $('.js-work-strip[data-work-id=98686150]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686150,"title":"Identification of extracellular enzyme producing thermophilic bacilli from Balcova (Agamemnon) geothermal site by ITS rDNA RFLP","translated_title":"","metadata":{"publisher":"Oxford University Press (OUP)","ai_title_tag":"Thermophilic Bacilli with Extracellular Enzymes from Balcova","grobid_abstract":"Aims: Molecular characterization of extracellular enzyme producing thermophilic bacilli from Balcova geothermal site. Methods and Results: Three types of geothermal samples were collected: mud, re-injection water, and samples from uncontrolled hydrothermal vents. Isolates grown at 55°C in culture media prepared in sterilized re-injection water, were screened for extracellular enzyme activity by using eight different substrates: casein, carboxymethylcellulose, pectin, polygalacturonic acid (PGA), soluble starch, Tween 20 and 80, and xylan. In total, 109 thermoaerophilic isolates were selected. All of the isolates could hydrolyse Tween 20 (100%) but not Tween 80. Soluble starch was hydrolysed by 96%, casein by 55%, xylan and carboxymethylcellulose by 9%, and pectin and PGA by 2% of the isolates. The isolates were grouped into 14 different homology groups by the restriction pattern analysis of 16S-internal transcribed spacer (ITS) rDNA RFLP. Each of the RFLP groups was also studied by 16S rRNA gene partial sequence analysis. Plasmid DNA profiles revealed that 15 of the isolated strains contained small plasmid DNA molecules ranging in size from 12 000 to 35 000 bp. Conclusions: Combined analysis of 16S-ITS rDNA RFLP and 16S rRNA gene partial sequence results indicated the presence of novel or existing species of Anoxybacillus (nine species) and Geobacillus (three species). Significance and Impact of the Study: In this study 16S-ITS rDNA RFLP was applied for the first time to differentiate thermophilic bacilli. It was also the first study on thermophilic bacilli of Balcova geothermal site.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Journal of Applied Microbiology","grobid_abstract_attachment_id":99969917},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686150/Identification_of_extracellular_enzyme_producing_thermophilic_bacilli_from_Balcova_Agamemnon_geothermal_site_by_ITS_rDNA_RFLP","translated_internal_url":"","created_at":"2023-03-17T06:03:29.110-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969917,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969917/thumbnails/1.jpg","file_name":"4729.pdf","download_url":"https://www.academia.edu/attachments/99969917/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Identification_of_extracellular_enzyme_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969917/4729-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_extracellular_enzyme_p.pdf\u0026Expires=1732984354\u0026Signature=EOLUMJkwoYMhu1zX6dmesFUGtW7MK4LnqpYZ~E4CvwxckH1awJO0m56CVbcZ5tFuFo~VFbPUgkK44uGEugB3ZYjL~jJnDVnFcAuxoCXKv2b5KKwpPXKac076YBw~Ys7WLgu7ojmh4lfONFOoLiNea2ousLZG6O~q-a~YFlGLYRY~ekc1SOM1X-0Jl-fbkynZU7fd~mPpN3JOmo9VQjGCakt0p6TCyWft7i2WgIJyUgMoaNqtSBX9yCc1aX9ek8nZfw7nDn7Wfj-hxTfGENJg5O29~lw1E6qukfs0tnsDOkwdKs77Y5Z2w8j0g~ext0ADlGcjTs3im~Tk2IVbOVOMcQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Identification_of_extracellular_enzyme_producing_thermophilic_bacilli_from_Balcova_Agamemnon_geothermal_site_by_ITS_rDNA_RFLP","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969917,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969917/thumbnails/1.jpg","file_name":"4729.pdf","download_url":"https://www.academia.edu/attachments/99969917/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Identification_of_extracellular_enzyme_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969917/4729-libre.pdf?1679062078=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_extracellular_enzyme_p.pdf\u0026Expires=1732984354\u0026Signature=EOLUMJkwoYMhu1zX6dmesFUGtW7MK4LnqpYZ~E4CvwxckH1awJO0m56CVbcZ5tFuFo~VFbPUgkK44uGEugB3ZYjL~jJnDVnFcAuxoCXKv2b5KKwpPXKac076YBw~Ys7WLgu7ojmh4lfONFOoLiNea2ousLZG6O~q-a~YFlGLYRY~ekc1SOM1X-0Jl-fbkynZU7fd~mPpN3JOmo9VQjGCakt0p6TCyWft7i2WgIJyUgMoaNqtSBX9yCc1aX9ek8nZfw7nDn7Wfj-hxTfGENJg5O29~lw1E6qukfs0tnsDOkwdKs77Y5Z2w8j0g~ext0ADlGcjTs3im~Tk2IVbOVOMcQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":7730,"name":"Geothermal","url":"https://www.academia.edu/Documents/in/Geothermal"},{"id":19703,"name":"Applied microbiology","url":"https://www.academia.edu/Documents/in/Applied_microbiology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":54433,"name":"Phylogeny","url":"https://www.academia.edu/Documents/in/Phylogeny"},{"id":112332,"name":"Bacillus","url":"https://www.academia.edu/Documents/in/Bacillus"},{"id":168196,"name":"Horses","url":"https://www.academia.edu/Documents/in/Horses"},{"id":190363,"name":"Plasmids","url":"https://www.academia.edu/Documents/in/Plasmids"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":231547,"name":"Soil Microbiology","url":"https://www.academia.edu/Documents/in/Soil_Microbiology"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme"},{"id":469102,"name":"Feces","url":"https://www.academia.edu/Documents/in/Feces"},{"id":526690,"name":"Similarity analysis","url":"https://www.academia.edu/Documents/in/Similarity_analysis"},{"id":676195,"name":"Pectins","url":"https://www.academia.edu/Documents/in/Pectins"},{"id":809882,"name":"Base Sequence","url":"https://www.academia.edu/Documents/in/Base_Sequence"},{"id":1925906,"name":"Bacilli","url":"https://www.academia.edu/Documents/in/Bacilli"},{"id":2545897,"name":"Hot Springs","url":"https://www.academia.edu/Documents/in/Hot_Springs"}],"urls":[{"id":29866544,"url":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1365-2672.2004.02374.x/fullpdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="98686149"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/98686149/Prolactin_receptor_gene_expression_in_rat_splenocytes_and_thymocytes_during_oestrous_cycle_pregnancy_and_lactation"><img alt="Research paper thumbnail of Prolactin receptor gene expression in rat splenocytes and thymocytes during oestrous cycle, pregnancy and lactation" class="work-thumbnail" src="https://attachments.academia-assets.com/99969914/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/98686149/Prolactin_receptor_gene_expression_in_rat_splenocytes_and_thymocytes_during_oestrous_cycle_pregnancy_and_lactation">Prolactin receptor gene expression in rat splenocytes and thymocytes during oestrous cycle, pregnancy and lactation</a></div><div class="wp-workCard_item"><span>Cell Proliferation</span><span>, 1997</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8e29fe3989b998ae46a3810aab75cc95" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":99969914,"asset_id":98686149,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/99969914/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="98686149"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="98686149"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 98686149; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=98686149]").text(description); $(".js-view-count[data-work-id=98686149]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 98686149; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='98686149']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 98686149, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8e29fe3989b998ae46a3810aab75cc95" } } $('.js-work-strip[data-work-id=98686149]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":98686149,"title":"Prolactin receptor gene expression in rat splenocytes and thymocytes during oestrous cycle, pregnancy and lactation","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"Much evidence suggests that prolactin (PRL) has an immunoregulatory function. Part of this evidence is that the receptors for PRL are present on lymphocytes. Probably the effects of PRL on cells of the immune system depend on the level and specific forms of PRL-R present on the target cells. Therefore, PRL-R expression at both protein and mRNA levels was examined during oestrous cycle, pregnancy and lactation using Western blotting and PCR analysis. Antibody to the long form of PRL-R detected 84 and 42 kDa protein bands in the spleen but only 84 kDa band in the thymus. The expression pattern of these two protein bands was different in the spleen, suggesting that these two isoforms of PRL-R long form are differentially regulated by the hormones of oestrous cycle. In addition, depending on the tissue, the level of mRNA for the short and long forms of PRL-R showed a significant change at different stages of oestrous cycle. Moreover, 42 and 84 kDa PRL-R bands were detected in both spleen and thymus throughout the pregnancy and lactation; however, the expression pattern of 84 kDa protein band was different between tissues. This finding suggests that each tissue exhibits differential response to hormones which affect PRL-R content. An anterior pituitary hormone PRL is primarily responsible for the development of mammary gland and the stimulation of milk protein genes. In addition, it has effect on reproduction, growth, metabolism, behaviour and immunoregulation. Immunoregulatory function of PRL has been supported by many studies. For example, decreased antibody production as well as cell mediated immunity have been observed in hypohysectomized rats (Nagy \u0026-Berczi 1978). Administration of PRL or implantation of pituitary gland reconstituted these immune functions (Berczi et al. 1981, Nagy et al. 1983). In addition, PRL has been shown to regulate DNA synthesis in vivo in lymphoid tissue (Berczi et al. 1991) and to act directly on splenocytes and thymocytes in vitro (Mukherjee et al. 1990, Viselli, Stanek \u0026 Mukherjee 1991). PRL-R expression has been shown in lymphoid cells. For example, binding studics with '2sI-labelled PRL provided evidence that human T-and B-cells have PRL-R (Russell 1985). More definitive studies based on the use of antibodies to PRL-R and flow cytometry confirmed these findings; and indicated that many subsets of rat splenocytes (Viselli \u0026 Mastro 1Y93), rat and murine lymphoid cells (Koh \u0026 Phillips 1YY3, Gagnerault et al.","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"Cell Proliferation","grobid_abstract_attachment_id":99969914},"translated_abstract":null,"internal_url":"https://www.academia.edu/98686149/Prolactin_receptor_gene_expression_in_rat_splenocytes_and_thymocytes_during_oestrous_cycle_pregnancy_and_lactation","translated_internal_url":"","created_at":"2023-03-17T06:03:28.935-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":262028830,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":99969914,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969914/thumbnails/1.jpg","file_name":"4499.pdf","download_url":"https://www.academia.edu/attachments/99969914/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prolactin_receptor_gene_expression_in_ra.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969914/4499-libre.pdf?1679062083=\u0026response-content-disposition=attachment%3B+filename%3DProlactin_receptor_gene_expression_in_ra.pdf\u0026Expires=1732984354\u0026Signature=Lvv8yZhE-eOe2H2JQQIi1D~Re8qCAE9V3k6EyjyM8nUKCX4fv~pcgTf2KT7tPCiXJSu7xk2QJD7ZWFniO7ZcED-YP5W-YDAg1jOxeHO1M8P2cgMP7cAVmfEysl1DsSO-hk9olE-fN3x-ZJt8WHGq2lol75m9IwlF~93Pp3urbfJMWcJ8-cDflU0GjETu4JNnWuNrJhl5D8pwQ7Y~EvS4DUqkM2QZ69li2dhS5XL33fCi0FurkMUef39RgXj2Mj4M0QaJeHDaZ7kgvW2fYof-sPuh2XwEAXMmD9iJkr7dBKOaVrr2kUOujra4Oe2NCl26c8fnup09957k3EuaSHKC8g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Prolactin_receptor_gene_expression_in_rat_splenocytes_and_thymocytes_during_oestrous_cycle_pregnancy_and_lactation","translated_slug":"","page_count":17,"language":"en","content_type":"Work","owner":{"id":262028830,"first_name":"Hatice","middle_initials":null,"last_name":"Gunes","page_name":"HaticeGunes6","domain_name":"independent","created_at":"2023-03-17T05:58:55.362-07:00","display_name":"Hatice Gunes","url":"https://independent.academia.edu/HaticeGunes6"},"attachments":[{"id":99969914,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/99969914/thumbnails/1.jpg","file_name":"4499.pdf","download_url":"https://www.academia.edu/attachments/99969914/download_file?st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&st=MTczMjk4MDc1NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prolactin_receptor_gene_expression_in_ra.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/99969914/4499-libre.pdf?1679062083=\u0026response-content-disposition=attachment%3B+filename%3DProlactin_receptor_gene_expression_in_ra.pdf\u0026Expires=1732984354\u0026Signature=Lvv8yZhE-eOe2H2JQQIi1D~Re8qCAE9V3k6EyjyM8nUKCX4fv~pcgTf2KT7tPCiXJSu7xk2QJD7ZWFniO7ZcED-YP5W-YDAg1jOxeHO1M8P2cgMP7cAVmfEysl1DsSO-hk9olE-fN3x-ZJt8WHGq2lol75m9IwlF~93Pp3urbfJMWcJ8-cDflU0GjETu4JNnWuNrJhl5D8pwQ7Y~EvS4DUqkM2QZ69li2dhS5XL33fCi0FurkMUef39RgXj2Mj4M0QaJeHDaZ7kgvW2fYof-sPuh2XwEAXMmD9iJkr7dBKOaVrr2kUOujra4Oe2NCl26c8fnup09957k3EuaSHKC8g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":19826,"name":"Lactation","url":"https://www.academia.edu/Documents/in/Lactation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":64657,"name":"Prolactin","url":"https://www.academia.edu/Documents/in/Prolactin"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence"},{"id":906079,"name":"Antibody Detection","url":"https://www.academia.edu/Documents/in/Antibody_Detection"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"},{"id":1847499,"name":"Estrous cycle","url":"https://www.academia.edu/Documents/in/Estrous_cycle"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data"},{"id":2950546,"name":"Animal cell","url":"https://www.academia.edu/Documents/in/Animal_cell"}],"urls":[{"id":29866543,"url":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1365-2184.1997.tb00936.x/fullpdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "b487c1a4b74da89c1a5309eb141b9cdd34ba9c6b01f416104537e214e31a488a", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="/Vz5+XBgDxlKXf3Xc013+Ovj4PT0gpuqdxXYNfWo3CuXBE1DuxlYoBBb7NgLKgLONXZiFGJj7MW2+EAeBA8Pgg==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/HaticeGunes6" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="z/8ho5uyZQT9T0ducSSeFQKSTNz67mJQ5qyLTwF3yoqlp5UZUMsyvadJVmEJQ+sj3AfOPGwPFT8nQRNk8NAZIw==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>