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rotate(270deg);" class="fr-fic fr-dii" data-id="54a8c63d-dd4f-4683-b09a-39f4f5eb13b6" data-name="Teal-Triangle-Full-Opacity" alt="teal triangle graphic"><div><h1 class="d-none d-md-block">R&D Pipeline</h1><h4 class="d-block d-md-none">R&D Pipeline</h4></div></div> </div> </div> </div> <div class="row one-column-section"> <div class="col-md-12"> <div class="fr-view"> <div class="d-flex justify-content-between" style="background-color:#c6ebe4;padding:4vw 7vw 0vw 7vw;"><div class="col-md-4"><h3 style="color:#387e86;">Pipeline of Key Proprietary Product Candidates</h3></div><div class="col-md-6"><h5>We have a pipeline of product candidates in development for psychiatric and neurological disorders.</h5><h5 class="mb-0"><br>These programs are investigating treatments or indications that have not received approval from a health authority. The information presented is not intended to convey conclusions of safety or efficacy. There is no guarantee that the outcome of these studies will result in approval by a health authority.</h5></div></div> </div> </div> </div> </div> <div class="pipeline"> <div> <div class="head d-none d-md-block"> <ul> <li>Discovery</li> <li>Preclinical</li> <li>Phase 1</li> <li>Phase 2</li> <li>Phase 3</li> </ul> </div> <div class="body"> <ul> <li class="molecule py-3"> <p class="m-0 pb-4">Olanzapine and samidorphan</p> <div class="toggle-overlay"></div> <ul> <li class="product"> <p>Schizophrenia and Bipolar I Disorder (Pediatric)</p> <div class="my-3 phase-100"> <div style="width:100%"></div> </div> <p class="d-md-none pb-3"> <span>Phase 3</span> </p> </li> </ul> <div class="extra"> <div><strong>Overview</strong> <p>Olanzapine and samidorphan is a once-daily, oral atypical antipsychotic drug approved for adults in the U.S.</p></div> <div><strong>Clinical Trials</strong> <p>Olanzapine and samidorphan is currently being evaluated for pediatric use in a phase 3 study. For more information about this study, please visit <strong><a href="https://www.enlightenyouthstudy.com" target="_blank">enlightenyouthstudy.com</a></strong> (U.S. audiences only) or <a href="https://www.clinicaltrials.gov/study/NCT05303064" target="_blank"><strong>clinicaltrials.gov/study/NCT05303064</strong></a>.</p></div> <div class="d-flex m-0"> </div> </div> </li> <li class="molecule py-3"> <p class="m-0 pb-4">ALKS 2680</p> <div class="toggle-overlay"></div> <ul> <li class="product"> <p>Narcolepsy Type 1</p> <div class="my-3 phase-80"> <div style="width:80%"></div> </div> <p class="d-md-none pb-3"> <span>Phase 2</span> </p> </li> <li class="product"> <p>Narcolepsy Type 2</p> <div class="my-3 phase-80"> <div style="width:80%"></div> </div> <p class="d-md-none pb-3"> <span>Phase 2</span> </p> </li> <li class="product"> <p>Idiopathic Hypersomnia</p> <div class="my-3 phase-60"> <div style="width:60%"></div> </div> <p class="d-md-none pb-3"> <span>Phase 1</span> </p> </li> </ul> <div class="extra"> <div><strong>Overview</strong> <p>ALKS 2680 is an investigational, oral orexin 2 receptor agonist in development as a once-daily treatment for narcolepsy type 1, narcolepsy type 2 and idiopathic hypersomnia.</p> </div> <div><strong>Clinical Trials</strong> <p>ALKS 2680 is currently being evaluated in Vibrance-1, a phase 2 study in adults with narcolepsy type 1, and Vibrance-2, a phase 2 study in adults with narcolepsy type 2.<br /> <br /> For more information about these studies, please visit <strong><a href="https://vibrancestudies.com/?utm_source=alkermes&utm_medium=pipeline&utm_campaign=pipeline-2024" target="_blank">vibrancestudies.com</a></strong> (for U.S. audiences only) or the respective clinicaltrials.gov listings:</p> <ul> <li><strong>Vibrance-1: <a href="https://www.clinicaltrials.gov/study/NCT06358950" target="_blank">clinicaltrials.gov/study/NCT06358950</a></strong></li> <li><strong>Vibrance-2: <a href="https://www.clinicaltrials.gov/study/NCT06555783" target="_blank">clinicaltrials.gov/study/NCT06555783</a></strong></li> </ul> </div> <div class="d-flex m-0"> </div> </div> </li> <li class="molecule py-3"> <p class="m-0 pb-4">ALKS 4510</p> <div class="toggle-overlay"></div> <ul> <li class="product"> <p>Neuroscience Indications</p> <div class="my-3 phase-39"> <div style="width:39%"></div> </div> <p class="d-md-none pb-3"> <span>Preclinical</span> </p> </li> </ul> <div class="extra"> <div><strong>Overview</strong> <p>ALKS 4510 is an investigational orexin 2 receptor agonist being evaluated preclinically for the treatment of central nervous system disorders.</p> </div> <div class="d-flex m-0"> </div> </div> </li> <li class="molecule py-3"> <p class="m-0 pb-4">ALKS 7290</p> <div class="toggle-overlay"></div> <ul> <li class="product"> <p>Neuroscience Indications</p> <div class="my-3 phase-39"> <div style="width:39%"></div> </div> <p class="d-md-none pb-3"> <span>Preclinical</span> </p> </li> </ul> <div class="extra"> <div><strong>Overview</strong> <p>ALKS 7290 is an investigational orexin 2 receptor agonist being evaluated preclinically for the treatment of central nervous system disorders.</p> </div> <div class="d-flex m-0"> </div> </div> </li> </ul> </div> <div class="foot"> <div class="fr-view"> <div style="display:flex;flex-direction:row;justify-content:space-between;flex-wrap:wrap;"><div style="width:100%;"><em>Last updated: January 2025</em></div></div> </div> <div> </div> </div> </div> </div> <div> <div> </div> </div> </div> </div> <div class="footer-wrapper"> <footer> <div class="footer-container"> <div class="row"> <div class="col-xs-3 logo"> <img src="/images/logo.svg" alt="logo" /> </div> <div class="col-xs-9 col-md-6"> <ul> <li> <a href="/contact-us">Contact Us</a> </li> <li> <a href="/terms-of-use">Terms of Use</a> </li> <li> <a href="/privacy">Privacy Policy</a> </li> <li> <a href="/sitemap">Sitemap</a> </li> </ul> </div> <div class="col-xs-3"> <div class="d-none d-md-block col-md-3"></div> <div class="col-xs-3"> <a href="https://www.youtube.com/channel/UC1CXRHrg3JzXO962jQctF7w" target="_blank" class="followus-link"> <img src="/images/youtube_logo.svg" alt="logo" /> </a> </div> <div class="col-xs-3"> <a href="https://twitter.com/alkermes" target="_blank" class="followus-link"> <img src="/images/tw-x_logo.svg" alt="logo" /> </a> </div> <div class="col-xs-3"> <a href="https://www.linkedin.com/company/alkermes" target="_blank" class="followus-link"> <img src="/images/li_logo.svg" alt="logo" /> </a> </div> </div> <div class="col-md-12 col-xs-9"> <div class="copyright"> © 2025 Alkermes. 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