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micelles</title> <meta name="description" content="Search results for: micelles"> <meta name="keywords" content="micelles"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="micelles"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 54</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: micelles</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">54</span> Amino Acid Based Biodegradable Amphiphilic Polymers and Micelles as Drug Delivery Systems: Synthesis and Study </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sophio%20Kobauri">Sophio Kobauri</a>, <a href="https://publications.waset.org/abstracts/search?q=Vladimir%20P.%20Torchilin"> Vladimir P. Torchilin</a>, <a href="https://publications.waset.org/abstracts/search?q=David%20Tugushi"> David Tugushi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ramaz%20Katsarava"> Ramaz Katsarava</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanotherapy is an actual newest mode of treatment numerous diseases using nanoparticles (NPs) loading with different pharmaceuticals. NPs of biodegradable polymeric micelles (PMs) are gaining increased attention for their numerous and attractive abilities to be used in a variety of applications in the various fields of medicine. The present paper deals with the synthesis of a class of biodegradable micelle-forming polymers, namely ABA triblock-copolymer in which A-blocks represent amino-poly(ethylene glycol) (H<sub>2</sub>N-PEG) and B-block is biodegradable amino acid-based poly(ester amide) constituted of α-amino acid – L-phenylalanine. The obtained copolymer formed micelles of 70±4 nm size at 10 mg/mL concentration. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amino%20acids" title="amino acids">amino acids</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20poly%20%28ester%20amide%29" title=" biodegradable poly (ester amide)"> biodegradable poly (ester amide)</a>, <a href="https://publications.waset.org/abstracts/search?q=amphiphilic%20triblock-copolymer" title=" amphiphilic triblock-copolymer"> amphiphilic triblock-copolymer</a>, <a href="https://publications.waset.org/abstracts/search?q=micelles" title=" micelles"> micelles</a> </p> <a href="https://publications.waset.org/abstracts/85545/amino-acid-based-biodegradable-amphiphilic-polymers-and-micelles-as-drug-delivery-systems-synthesis-and-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85545.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">191</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">53</span> Bile Salt Induced Microstructural Changes of Gemini Surfactant Micelles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vijaykumar%20Patel">Vijaykumar Patel</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Bahadur"> P. Bahadur</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Microstructural evolution of a cationic gemini surfactant 12-4-12 micelles in the presence of bile salts has been investigated using different techniques. A negative value of interaction parameter evaluated from surface tension measurements is a signature of strong synergistic interaction between oppositely charged surfactants. Both the bile salts compete with each other in inducing the micellar transition of 12-4-12 micelles depending on their hydrophobicity. Viscosity measurements disclose that loading of bile salts induces morphological changes in 12-4-12 micelles; sodium deoxycholate is more efficient in altering the aggregation behaviour of 12-4-12 micelles compared to sodium cholate and presents pronounced increase in viscosity and micellar growth which is suppressed at elevated temperatures. A remarkable growth of 12-4-12 micelles in the presence of sodium deoxycholate at low pH has been ascribed to the solubilization of bile acids formed in acidic medium. Small angle neutron scattering experiments provided size and shape of 12-4-12/bile salt mixed micelles are explicated on the basis of hydrophobicity of bile salts. The location of bile salts in micelle was determined from nuclear overhauser effect spectroscopy. The present study characterizes 12-4-12 gemini-bile salt mixed systems which significantly enriches our knowledge, and such a structural transition provides an opportunity to use these bioamphiphiles as delivery vehicles and in some pharmaceutical formulations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gemini%20surfactants" title="gemini surfactants">gemini surfactants</a>, <a href="https://publications.waset.org/abstracts/search?q=bile%20salts" title=" bile salts"> bile salts</a>, <a href="https://publications.waset.org/abstracts/search?q=SANS%20%28small%20angle%20neutron%20scattering%29" title=" SANS (small angle neutron scattering)"> SANS (small angle neutron scattering)</a>, <a href="https://publications.waset.org/abstracts/search?q=NOESY%20%28nuclear%20overhauser%20effect%20spectroscopy%29" title=" NOESY (nuclear overhauser effect spectroscopy)"> NOESY (nuclear overhauser effect spectroscopy)</a> </p> <a href="https://publications.waset.org/abstracts/75883/bile-salt-induced-microstructural-changes-of-gemini-surfactant-micelles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75883.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">151</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">52</span> Micelles Made of Pseudo-Proteins for Solubilization of Hydrophobic Biologicals</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sophio%20Kobauri">Sophio Kobauri</a>, <a href="https://publications.waset.org/abstracts/search?q=David%20Tugushi"> David Tugushi</a>, <a href="https://publications.waset.org/abstracts/search?q=Vladimir%20P.%20Torchilin"> Vladimir P. Torchilin</a>, <a href="https://publications.waset.org/abstracts/search?q=Ramaz%20Katsarava"> Ramaz Katsarava</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrophobic / hydrophilically modified functional polymers are of high interest in modern biomedicine due to their ability to solubilize water-insoluble / poorly soluble (hydrophobic) drugs. Among the many approaches that are being developed in this direction, one of the most effective methods is the use of polymeric micelles (PMs) (micelles formed by amphiphilic block-copolymers) for solubilization of hydrophobic biologicals. For therapeutic purposes, PMs are required to be stable and biodegradable, although quite a few amphiphilic block-copolymers are described capable of forming stable micelles with good solubilization properties. For obtaining micelle-forming block-copolymers, polyethylene glycol (PEG) derivatives are desirable to use as hydrophilic shell because it represents the most popular biocompatible hydrophilic block and various hydrophobic blocks (polymers) can be attached to it. Although the construction of the hydrophobic core, due to the complex requirements and micelles structure development, is the very actual and the main problem for nanobioengineers. Considering the above, our research goal was obtaining biodegradable micelles for the solubilization of hydrophobic drugs and biologicals. For this purpose, we used biodegradable polymers– pseudo-proteins (PPs)(synthesized with naturally occurring amino acids and other non-toxic building blocks, such as fatty diols and dicarboxylic acids) as hydrophobic core since these polymers showed reasonable biodegradation rates and excellent biocompatibility. In the present study, we used the hydrophobic amino acid – L-phenylalanine (MW 4000-8000Da) instead of L-leucine. Amino-PEG (MW 2000Da) was used as hydrophilic fragments for constructing the suitable micelles. The molecular weight of PP (the hydrophobic core of micelle) was regulated by variation of used monomers ratios. Micelles were obtained by dissolving of synthesized amphiphilic polymer in water. The micelle-forming property was tested using dynamic light scattering (Malvern zetasizer NanoZSZEN3600). The study showed that obtaining amphiphilic block-copolymer form stable neutral micelles 100 ± 7 nm in size at 10mg/mL concentration, which is considered as an optimal range for pharmaceutical micelles. The obtained preliminary data allow us to conclude that the obtained micelles are suitable for the delivery of poorly water-soluble drugs and biologicals. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amino%20acid%20%E2%80%93%20L-phenylalanine" title="amino acid – L-phenylalanine">amino acid – L-phenylalanine</a>, <a href="https://publications.waset.org/abstracts/search?q=pseudo-proteins" title=" pseudo-proteins"> pseudo-proteins</a>, <a href="https://publications.waset.org/abstracts/search?q=amphiphilic%20block-copolymers" title=" amphiphilic block-copolymers"> amphiphilic block-copolymers</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20micelles" title=" biodegradable micelles"> biodegradable micelles</a> </p> <a href="https://publications.waset.org/abstracts/109290/micelles-made-of-pseudo-proteins-for-solubilization-of-hydrophobic-biologicals" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/109290.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">134</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">51</span> Diselenide-Linked Redox Stimuli-Responsive Methoxy Poly(Ethylene Glycol)-b-Poly(Lactide-Co-Glycolide) Micelles for the Delivery of Doxorubicin in Cancer Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yihenew%20Simegniew%20Birhan">Yihenew Simegniew Birhan</a>, <a href="https://publications.waset.org/abstracts/search?q=Hsieh%20Chih%20Tsai"> Hsieh Chih Tsai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The recent advancements in synthetic chemistry and nanotechnology fostered the development of different nanocarriers for enhanced intracellular delivery of pharmaceutical agents to tumor cells. Polymeric micelles (PMs), characterized by small size, appreciable drug loading capacity (DLC), better accumulation in tumor tissue via enhanced permeability and retention (EPR) effect, and the ability to avoid detection and subsequent clearance by the mononuclear phagocyte (MNP) system, are convenient to improve the poor solubility, slow absorption and non-selective biodistribution of payloads embedded in their hydrophobic cores and hence, enhance the therapeutic efficacy of chemotherapeutic agents. Recently, redox-responsive polymeric micelles have gained significant attention for the delivery and controlled release of anticancer drugs in tumor cells. In this study, we synthesized redox-responsive diselenide bond containing amphiphilic polymer, Bi(mPEG-PLGA)-Se₂ from mPEG-PLGA, and 3,3'-diselanediyldipropanoic acid (DSeDPA) using DCC/DMAP as coupling agents. The successful synthesis of the copolymers was verified by different spectroscopic techniques. Above the critical micelle concentration, the amphiphilic copolymer, Bi(mPEG-PLGA)-Se₂, self-assembled into stable micelles. The DLS data indicated that the hydrodynamic diameter of the micelles (123.9 ± 0.85 nm) was suitable for extravasation into the tumor cells through the EPR effect. The drug loading content (DLC) and encapsulation efficiency (EE) of DOX-loaded micelles were found to be 6.61 wt% and 54.9%, respectively. The DOX-loaded micelles showed initial burst release accompanied by sustained release trend where 73.94% and 69.54% of encapsulated DOX was released upon treatment with 6mM GSH and 0.1% H₂O₂, respectively. The biocompatible nature of Bi(mPEG-PLGA)-Se₂ copolymer was confirmed by the cell viability study. In addition, the DOX-loaded micelles exhibited significant inhibition against HeLa cells (44.46%), at a maximum dose of 7.5 µg/mL. The fluorescent microscope images of HeLa cells treated with 3 µg/mL (equivalent DOX concentration) revealed efficient internalization and accumulation of DOX-loaded Bi(mPEG-PLGA)-Se₂ micelles in the cytosol of cancer cells. In conclusion, the intelligent, biocompatible, and the redox stimuli-responsive behavior of Bi(mPEG-PLGA)-Se₂ copolymer marked the potential applications of diselenide-linked mPEG-PLGA micelles for the delivery and on-demand release of chemotherapeutic agents in cancer cells. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anticancer%20drug%20delivery" title="anticancer drug delivery">anticancer drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=diselenide%20bond" title=" diselenide bond"> diselenide bond</a>, <a href="https://publications.waset.org/abstracts/search?q=polymeric%20micelles" title=" polymeric micelles"> polymeric micelles</a>, <a href="https://publications.waset.org/abstracts/search?q=redox-responsive" title=" redox-responsive"> redox-responsive</a> </p> <a href="https://publications.waset.org/abstracts/118642/diselenide-linked-redox-stimuli-responsive-methoxy-polyethylene-glycol-b-polylactide-co-glycolide-micelles-for-the-delivery-of-doxorubicin-in-cancer-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/118642.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">110</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">50</span> Targeted Delivery of Docetaxel Drug Using Cetuximab Conjugated Vitamin E TPGS Micelles Increases the Anti-Tumor Efficacy and Inhibit Migration of MDA-MB-231 Triple Negative Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=V.%20K.%20Rajaletchumy">V. K. Rajaletchumy</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20L.%20Chia"> S. L. Chia</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20I.%20Setyawati"> M. I. Setyawati</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20S.%20Muthu"> M. S. Muthu</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20S.%20Feng"> S. S. Feng</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20T.%20Leong"> D. T. Leong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Triple negative breast cancers (TNBC) can be classified as one of the most aggressive with a high rate of local recurrences and systematic metastases. TNBCs are insensitive to existing hormonal therapy or targeted therapies such as the use of monoclonal antibodies, due to the lack of oestrogen receptor (ER) and progesterone receptor (PR) and the absence of overexpression of human epidermal growth factor receptor 2 (HER2) compared with other types of breast cancers. The absence of targeted therapies for selective delivery of therapeutic agents into tumours, led to the search for druggable targets in TNBC. In this study, we developed a targeted micellar system of cetuximab-conjugated micelles of D-α-tocopheryl polyethylene glycol succinate (vitamin E TPGS) for targeted delivery of docetaxel as a model anticancer drug for the treatment of TNBCs. We examined the efficacy of our micellar system in xenograft models of triple negative breast cancers and explored the effect of the micelles on post-treatment tumours in order to elucidate the mechanism underlying the nanomedicine treatment in oncology. The targeting micelles were found preferentially accumulated in tumours immediately after the administration of the micelles compare to normal tissue. The fluorescence signal gradually increased up to 12 h at the tumour site and sustained for up to 24 h, reflecting the increases in targeted micelles (TPFC) micelles in MDA-MB-231/Luc cells. In comparison, for the non-targeting micelles (TPF), the fluorescence signal was evenly distributed all over the body of the mice. Only a slight increase in fluorescence at the chest area was observed after 24 h post-injection, reflecting the moderate uptake of micelles by the tumour. The successful delivery of docetaxel into tumour by the targeted micelles (TPDC) exhibited a greater degree of tumour growth inhibition than Taxotere® after 15 days of treatment. The ex vivo study has demonstrated that tumours treated with targeting micelles exhibit enhanced cell cycle arrest and attenuated proliferation compared with the control and with those treated non-targeting micelles. Furthermore, the ex vivo investigation revealed that both the targeting and non-targeting micellar formulations shows significant inhibition of cell migration with migration indices reduced by 0.098- and 0.28-fold, respectively, relative to the control. Overall, both the in vivo and ex vivo data increased the confidence that our micellar formulations effectively targeted and inhibited EGF-overexpressing MDA-MB-231 tumours. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20polymers" title="biodegradable polymers">biodegradable polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20nanotechnology" title=" cancer nanotechnology"> cancer nanotechnology</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20targeting" title=" drug targeting"> drug targeting</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20biomaterials" title=" molecular biomaterials"> molecular biomaterials</a>, <a href="https://publications.waset.org/abstracts/search?q=nanomedicine" title=" nanomedicine"> nanomedicine</a> </p> <a href="https://publications.waset.org/abstracts/50350/targeted-delivery-of-docetaxel-drug-using-cetuximab-conjugated-vitamin-e-tpgs-micelles-increases-the-anti-tumor-efficacy-and-inhibit-migration-of-mda-mb-231-triple-negative-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50350.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">281</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">49</span> Microstructure of Virgin and Aged Asphalts by Small-Angle X-Ray Scattering</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dong%20Tang">Dong Tang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yongli%20Zhao"> Yongli Zhao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study of the microstructure of asphalt is of great importance for the analysis of its macroscopic properties. However, the peculiarities of the chemical composition of the asphalt itself and the limitations of existing direct imaging techniques have caused researchers to face many obstacles in studying the microstructure of asphalt. The advantage of small-angle X-ray scattering (SAXS) is that it allows quantitative determination of the internal structure of opaque materials and is suitable for analyzing the microstructure of materials. Therefore, the SAXS technique was used to study the evolution of microstructures on the nanoscale during asphalt aging. And the reasons for the change in scattering contrast during asphalt aging were also explained with the help of Fourier transform infrared spectroscopy (FTIR). SAXS experimental results show that the SAXS curves of asphalt are similar to the scattering curves of scattering objects with two-level structures. The Porod curve for asphalt shows that there is no obvious interface between the micelles and the surrounding mediums, and there is only a fluctuation of the hot electron density between the two. The Beaucage model fit SAXS patterns shows that the scattering coefficient P of the asphaltene clusters as well as the size of the micelles, gradually increase with the aging of the asphalt. Furthermore, aggregation exists between the micelles of asphalt and becomes more pronounced with increasing aging. During asphalt aging, the electron density difference between the micelles and the surrounding mediums gradually increases, leading to an increase in the scattering contrast of the asphalt. Under long-term aging conditions due to the gradual transition from maltenes to asphaltenes, the electron density difference between the micelles and the surrounding mediums decreases, resulting in a decrease in the scattering contrast of asphalt SAXS. Finally, this paper correlates the macroscopic properties of asphalt with microstructural parameters, and the results show that the high-temperature rutting resistance of asphalt is enhanced and the low-temperature cracking resistance decreases due to the aggregation of micelles and the generation of new micelles. These results are useful for understanding the relationship between changes in microstructure and changes in properties during asphalt aging and provide theoretical guidance for the regeneration of aged asphalt. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=asphalt" title="asphalt">asphalt</a>, <a href="https://publications.waset.org/abstracts/search?q=Beaucage%20model" title=" Beaucage model"> Beaucage model</a>, <a href="https://publications.waset.org/abstracts/search?q=microstructure" title=" microstructure"> microstructure</a>, <a href="https://publications.waset.org/abstracts/search?q=SAXS" title=" SAXS"> SAXS</a> </p> <a href="https://publications.waset.org/abstracts/165750/microstructure-of-virgin-and-aged-asphalts-by-small-angle-x-ray-scattering" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165750.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">80</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">48</span> Polymersomes in Drug Delivery: A Comparative Review with Liposomes and Micelles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Salma%20E.%20Ahmed">Salma E. Ahmed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Since the mid 50’s, enormous attention has been paid towards nanocarriers and their applications in drug and gene delivery. Among these vesicles, liposomes and micelles have been heavily investigated due to their many advantages over other types. Liposomes, for instance, are mostly distinguished by their ability to encapsulate hydrophobic, hydrophilic and amphiphilic drugs. Micelles, on the other hand, are self-assembled shells of lipids, amphiphilic or oppositely charged block copolymers that, once exposed to aqueous media, can entrap hydrophobic agents, and possess prolonged circulation in the bloodstream. Both carriers are considered compatible and biodegradable. Nevertheless, they have limited stabilities, chemical versatilities, and drug encapsulation efficiencies. In order to overcome these downsides, strategies for optimizing a novel drug delivery system that has the architecture of liposomes and polymeric characteristics of micelles have been evolved. Polymersomes are vehicles with fluidic cores and hydrophobic shells that are protected and isolated from the aqueous media by the hydrated hydrophilic brushes which give the carrier its distinctive polymeric bilayer shape. Similar to liposomes, this merit enables the carrier to encapsulate a wide range of agents, despite their affinities and solubilities in water. Adding to this, the high molecular weight of the amphiphiles that build the body of the polymersomes increases their colloidal and chemical stabilities and reduces the permeability of the polymeric membranes, which makes the vesicles more protective to the encapsulated drug. These carriers can also be modified in ways that make them responsive when targeted or triggered, by manipulating their composition and attaching moieties and conjugates to the body of the carriers. These appealing characteristics, in addition to the ease of synthesis, gave the polymersomes greater potentials in the area of drug delivery. Thus, their design and characterization, in comparison with liposomes and micelles, are briefly reviewed in this work. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title="controlled release">controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=liposomes" title=" liposomes"> liposomes</a>, <a href="https://publications.waset.org/abstracts/search?q=micelles" title=" micelles"> micelles</a>, <a href="https://publications.waset.org/abstracts/search?q=polymersomes" title=" polymersomes"> polymersomes</a>, <a href="https://publications.waset.org/abstracts/search?q=targeting" title=" targeting"> targeting</a> </p> <a href="https://publications.waset.org/abstracts/67371/polymersomes-in-drug-delivery-a-comparative-review-with-liposomes-and-micelles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67371.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">194</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">47</span> Preparation and Characterization of Nickel-Tungsten Nanoparticles Using Microemulsion Mediated Synthesis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Pal">S. Pal</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Singh"> R. Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Sivakumar"> S. Sivakumar</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Kunzru"> D. Kunzru</a> </p> <p class="card-text"><strong>Abstract:</strong></p> AOT stabilized reverse micelles of deionized water, dispersed in isooctane have been used to synthesize bimetallic nickel tungsten nanoparticles. Prepared nanoparticles were supported on γ-Al2O3 followed by calcination at 500oC. Characterizations of the nanoparticles were done by TEM, XRD, FTIR, XRF, TGA and BET. XRF results showed that this method gave good composition control with W/Ni weight ratio equal to 3.2. TEM images showed particle size of 5-10 nm. Removal of surfactant after calcination was confirmed by TGA and FTIR. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title="nanoparticles">nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=reverse%20micelles" title=" reverse micelles"> reverse micelles</a>, <a href="https://publications.waset.org/abstracts/search?q=nickel" title=" nickel"> nickel</a>, <a href="https://publications.waset.org/abstracts/search?q=tungsten" title=" tungsten "> tungsten </a> </p> <a href="https://publications.waset.org/abstracts/19384/preparation-and-characterization-of-nickel-tungsten-nanoparticles-using-microemulsion-mediated-synthesis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19384.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">592</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">46</span> Photophysics and Rotational Relaxation Dynamics of 6-Methoxyquinoline Fluorophore in Cationic Alkyltrimethylammonium Bromide Micelles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tej%20Varma%20Y">Tej Varma Y</a>, <a href="https://publications.waset.org/abstracts/search?q=Debi%20D.%20Pant"> Debi D. Pant</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Photophysics and rotational dynamics of the fluorescent probe, 6-methoxyquinoline (6MQ) with cationic surfactant, alkyltrimethylammonium bromide (nTAB) micelle solutions have been investigated (n = 12, 14 and 16). Absorption and emission peaks of the dye have been observed to shift at concentrations around critical micellar concentration (cmc) of nTAB compared to that of bulk solutions suggesting probe is in a lower polar environment. The probe senses changes in polarity (ET (30)) brought about by variation of surfactant chain length concentration and is invariably solubilized in the aqueous interface or palisade layer. The order of change in polarity observed was DTAB > CTAB > TTAB. The binding constant study shows that the probe binds strongest with TTAB (is of the order TTAB > CTAB > DTAB) due to deeper penetration into the micelle. The anisotropy decay for the probe in all the nTAB micelles studied have been rationalized based on a two-step model consisting of fast-restricted rotation of the probe and slow lateral diffusion of the probe in the micelle that is coupled to the overall rotation of the micelle. Fluorescence lifetime measurements of probe in the cationic micelles demonstrate the close proximity of the 6MQ to the Br - counterions. The fluorescence lifetimes of TTAB and DTAB are much shorter than in CTAB. These results indicate that 6MQ resides to a substantial degree in the head group region of the micelles. All the changes observed in the steady state fluorescence, microenvironment, fluorescence lifetimes, fluorescence anisotropy, and other calculations are in agreement with each other suggesting binding of the cationic surfactant with the neutral dye molecule. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=photophysics" title="photophysics">photophysics</a>, <a href="https://publications.waset.org/abstracts/search?q=chain%20length" title=" chain length"> chain length</a>, <a href="https://publications.waset.org/abstracts/search?q=ntaB" title=" ntaB"> ntaB</a>, <a href="https://publications.waset.org/abstracts/search?q=micelles" title=" micelles"> micelles</a> </p> <a href="https://publications.waset.org/abstracts/39913/photophysics-and-rotational-relaxation-dynamics-of-6-methoxyquinoline-fluorophore-in-cationic-alkyltrimethylammonium-bromide-micelles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39913.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">636</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">45</span> Development of Novel Amphiphilic Block Copolymer of Renewable ε-Decalactone for Drug Delivery Application</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Deepak%20Kakde">Deepak Kakde</a>, <a href="https://publications.waset.org/abstracts/search?q=Steve%20Howdle"> Steve Howdle</a>, <a href="https://publications.waset.org/abstracts/search?q=Derek%20Irvine"> Derek Irvine</a>, <a href="https://publications.waset.org/abstracts/search?q=Cameron%20Alexander"> Cameron Alexander</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The poor aqueous solubility is one of the major obstacles in the formulation development of many drugs. Around 70% of drugs are poorly soluble in aqueous media. In the last few decades, micelles have emerged as one of the major tools for solubilization of hydrophobic drugs. Micelles are nanosized structures (10-100nm) obtained by self-assembly of amphiphilic molecules into the water. The hydrophobic part of the micelle forms core which is surrounded by a hydrophilic outer shell called corona. These core-shell structures have been used as a drug delivery vehicle for many years. Although, the utility of micelles have been reduced due to the lack of sustainable materials. In the present study, a novel methoxy poly(ethylene glycol)-b-poly(ε-decalactone) (mPEG-b-PεDL) copolymer was synthesized by ring opening polymerization (ROP) of renewable ε-decalactone (ε-DL) monomers on methoxy poly(ethylene glycol) (mPEG) initiator using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as a organocatalyst. All the reactions were conducted in bulk to avoid the use of toxic organic solvents. The copolymer was characterized by nuclear magnetic resonance spectroscopy (NMR), gel permeation chromatography (GPC) and differential scanning calorimetry (DSC).The mPEG-b-PεDL block copolymeric micelles containing indomethacin (IND) were prepared by nanoprecipitation method and evaluated as drug delivery vehicle. The size of the micelles was less than 40nm with narrow polydispersity pattern. TEM image showed uniform distribution of spherical micelles defined by clear surface boundary. The indomethacin loading was 7.4% for copolymer with molecular weight of 13000 and drug/polymer weight ratio of 4/50. The higher drug/polymer ratio decreased the drug loading. The drug release study in PBS (pH7.4) showed a sustained release of drug over a period of 24hr. In conclusion, we have developed a new sustainable polymeric material for IND delivery by combining the green synthetic approach with the use of renewable monomer for sustainable development of polymeric nanomedicine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dopolymer" title="dopolymer">dopolymer</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%B5-decalactone" title=" ε-decalactone"> ε-decalactone</a>, <a href="https://publications.waset.org/abstracts/search?q=indomethacin" title=" indomethacin"> indomethacin</a>, <a href="https://publications.waset.org/abstracts/search?q=micelles" title=" micelles"> micelles</a> </p> <a href="https://publications.waset.org/abstracts/37066/development-of-novel-amphiphilic-block-copolymer-of-renewable-e-decalactone-for-drug-delivery-application" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37066.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">295</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">44</span> Pharmacokinetic and Tissue Distribution of Etoposide Loaded Modified Glycol Chitosan Nanoparticles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Akhtar%20Aman">Akhtar Aman</a>, <a href="https://publications.waset.org/abstracts/search?q=Abida%20Raza"> Abida Raza</a>, <a href="https://publications.waset.org/abstracts/search?q=Shumaila%20Bashir"> Shumaila Bashir</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehboob%20Alam"> Mehboob Alam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The development of efficient delivery systems remains a major concern in cancer chemotherapy as many efficacious anticancer drugs are hydrophobic and difficult to formulate. Nanomedicines based on drug-loaded amphiphilic glycol chitosan micelles offer potential advantages for the formulation of drugs such as etoposide that may improve the pharmacokinetics and reduce the formulation-related adverse effects observed with current formulations. Amphiphilic derivatives of glycol chitosan were synthesized by chemical grafting of palmitic acid N-hydroxysuccinimide and quaternization to glycol chitosan backbone. To this end, a 7.9 kDa glycol chitosan was modified by palmitoylation and quaternization, yielding a 13 kDa amphiphilic polymer. Micelles prepared from this amphiphilic polymer had a size of 162nm and were able to encapsulate up to 3 mg/ml etoposide. Pharmacokinetic results indicated that the GCPQ micelles transformed the biodistribution pattern and increased etoposide concentration in the brain significantly compared to free drugs after intravenous administration. AUC 0.5-24h showed statistically significant difference in ETP-GCPQ vs. Commercial preparation in liver (25 vs.70, p<0.001), spleen (27 vs.36, p<0.05), lungs (42 vs.136,p<0.001),kidneys(25 vs.70,p< 0.05),and brain(19 vs.9,p<0.001). ETP-GCPQ crossed the blood-brain barrier, and 4, 3.5, 2.6, 1.8, 1.7, 1.5, and 2.5 fold higher levels of etoposide were observed at 0.5, 1, 2, 4, 6, 12, and 24hrs; respectively suggesting these systems could deliver hydrophobic anticancer drugs such as etoposide to tumors but also increased their transport through the biological barriers, thus making it a good delivery system <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=glycol%20chitosan" title="glycol chitosan">glycol chitosan</a>, <a href="https://publications.waset.org/abstracts/search?q=micelles" title=" micelles"> micelles</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmacokinetics" title=" pharmacokinetics"> pharmacokinetics</a>, <a href="https://publications.waset.org/abstracts/search?q=tissue%20distribution" title=" tissue distribution"> tissue distribution</a> </p> <a href="https://publications.waset.org/abstracts/156481/pharmacokinetic-and-tissue-distribution-of-etoposide-loaded-modified-glycol-chitosan-nanoparticles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/156481.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">104</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">43</span> Mixed Micellization Study of Adiphenine Hydrochloride with 1-Decyl-3-Methylimidazolium Chloride</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abbul%20B.%20Khan">Abbul B. Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Neeraj%20Dohare"> Neeraj Dohare</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajan%20Patel"> Rajan Patel </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The mixed micellization of adiphenine hydrochloride (ADP) with 1-decyl-3-methylimidazolium chloride (C10mim.Cl), was investigated at different mole fractions and temperatures by surface tension measurements. The synergistic behavior (i.e., non-ideal behavior) for binary mixtures was explained by the deviation of critical micelle concentration (cmc) from ideal critical micelle concentration (cmc*), micellar mole fraction (Xim) from ideal micellar mole fraction (Xiideal), the values of interaction parameter (β) and activity coefficients (fi) (for both mixed micelles and mixed monolayer). The excess free energy (∆Gex) for the ADP- C10mim.Cl binary mixtures explain the stability of mixed micelles in comparison to micelles of pure ADP and C10mim.Cl. Interfacial parameters, i.e., Gibbs surface excess (Гmax), minimum head group area at air/ water interface (Amin), and free energy of micellization (ΔG0m) were also evaluated for the systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adiphenine%20hydrochloride" title="adiphenine hydrochloride">adiphenine hydrochloride</a>, <a href="https://publications.waset.org/abstracts/search?q=critical%20micelle%20concentration" title=" critical micelle concentration"> critical micelle concentration</a>, <a href="https://publications.waset.org/abstracts/search?q=interaction%20parameter" title=" interaction parameter"> interaction parameter</a>, <a href="https://publications.waset.org/abstracts/search?q=activity%20coefficient" title=" activity coefficient"> activity coefficient</a> </p> <a href="https://publications.waset.org/abstracts/21352/mixed-micellization-study-of-adiphenine-hydrochloride-with-1-decyl-3-methylimidazolium-chloride" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21352.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">269</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">42</span> 4-Allylpyrocatechol Loaded Polymeric Micelles for Solubility Enhancing and Effects on Streptococcus mutans Biofilms</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Siriporn%20Okonogi">Siriporn Okonogi</a>, <a href="https://publications.waset.org/abstracts/search?q=Pimpak%20Phumat"> Pimpak Phumat</a>, <a href="https://publications.waset.org/abstracts/search?q=Sakornrat%20Khongkhunthian"> Sakornrat Khongkhunthian</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Piper betle has been extensively reported for various pharmacological effects including antimicrobial activity. 4-Allylpyrocatechol (AC) is a principle active compound found in P. betle. However, AC has a problem of solubility in water. The aims of the present study were to prepare AC loaded polymeric micelles for enhancing its water solubility and to evaluate its anti-biofilm activity against oral phathogenic bacteria. AC was loaded in polymeric micelles (PM) of Pluronic F127 by using thin film hydration method to obtain AC loaded PM (PMAC). The results revealed that AC in the form of PMAC possessed high water solubility. PMAC particles were characterized using a transmission electron microscope and photon correlation spectroscopy. Determination of entrapment efficiency (EE) and loading capacity (LC) of PMAC was done by using high-performance liquid chromatography. The highest EE (86.33 ± 14.27 %) and LC (19.25 ± 3.18 %) of PMAC were found when the weight ratio of polymer to AC was 4 to 1. At this ratio, the particles showed spherical in shape with the size of 38.83 ± 1.36 nm and polydispersity index of 0.28 ± 0.10. Zeta potential of the particles is negative with the value of 16.43 ± 0.55 mV. Crystal violet assay and confocal microscopy were applied to evaluate the effects of PMAC on Streptococcus mutans biofilms using chlorhexidine (CHX) as a positive control. PMAC contained 1.5 mg/mL AC could potentially inhibit (102.01 ± 9.18%) and significantly eradicate (85.05 ± 2.03 %) these biofilms (p < 0.05). Comparison with CHX, PMAC showed slightly similar biofilm inhibition but significantly stronger biofilm eradication (p < 0.05) than CHX. It is concluded that PMAC can enhance water solubility and anti-biofilm activity of AC. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pluronic" title="pluronic">pluronic</a>, <a href="https://publications.waset.org/abstracts/search?q=polymeric%20micelles" title=" polymeric micelles"> polymeric micelles</a>, <a href="https://publications.waset.org/abstracts/search?q=solubility" title=" solubility"> solubility</a>, <a href="https://publications.waset.org/abstracts/search?q=4-allylpyrocathecol" title=" 4-allylpyrocathecol"> 4-allylpyrocathecol</a>, <a href="https://publications.waset.org/abstracts/search?q=Streptococcus%20mutans" title=" Streptococcus mutans"> Streptococcus mutans</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-biofilm" title=" anti-biofilm"> anti-biofilm</a> </p> <a href="https://publications.waset.org/abstracts/106535/4-allylpyrocatechol-loaded-polymeric-micelles-for-solubility-enhancing-and-effects-on-streptococcus-mutans-biofilms" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/106535.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">144</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">41</span> Tri/Tetra-Block Copolymeric Nanocarriers as a Potential Ocular Delivery System of Lornoxicam: Experimental Design-Based Preparation, in-vitro Characterization and in-vivo Estimation of Transcorneal Permeation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alaa%20Hamed%20Salama">Alaa Hamed Salama</a>, <a href="https://publications.waset.org/abstracts/search?q=Rehab%20Nabil%20Shamma"> Rehab Nabil Shamma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Polymeric micelles that can deliver drug to intended sites of the eye have attracted much scientific attention recently. The aim of this study was to review the aqueous-based formulation of drug-loaded polymeric micelles that hold significant promise for ophthalmic drug delivery. This study investigated the synergistic performance of mixed polymeric micelles made of linear and branched poly (ethylene oxide)-poly (propylene oxide) for the more effective encapsulation of Lornoxicam (LX) as a hydrophobic model drug. Methods: The co-micellization process of 10% binary systems combining different weight ratios of the highly hydrophilic poloxamers; Synperonic® PE/P84, and Synperonic® PE/F127 and the hydrophobic poloxamine counterpart (Tetronic® T701) was investigated by means of photon correlation spectroscopy and cloud point. The drug-loaded micelles were tested for their solubilizing capacity towards LX. Results: Results showed a sharp solubility increase from 0.46 mg/ml up to more than 4.34 mg/ml, representing about 136-fold increase. Optimized formulation was selected to achieve maximum drug solubilizing power and clarity with lowest possible particle size. The optimized formulation was characterized by 1HNMR analysis which revealed complete encapsulation of the drug within the micelles. Further investigations by histopathological and confocal laser studies revealed the non-irritant nature and good corneal penetrating power of the proposed nano-formulation. Conclusion: LX-loaded polymeric nanomicellar formulation was fabricated allowing easy application of the drug in the form of clear eye drops that do not cause blurred vision or discomfort, thus achieving high patient compliance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=confocal%20laser%20scanning%20microscopy" title="confocal laser scanning microscopy">confocal laser scanning microscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=Histopathological%20studies" title=" Histopathological studies"> Histopathological studies</a>, <a href="https://publications.waset.org/abstracts/search?q=Lornoxicam" title=" Lornoxicam"> Lornoxicam</a>, <a href="https://publications.waset.org/abstracts/search?q=micellar%20solubilization" title=" micellar solubilization"> micellar solubilization</a> </p> <a href="https://publications.waset.org/abstracts/30660/tritetra-block-copolymeric-nanocarriers-as-a-potential-ocular-delivery-system-of-lornoxicam-experimental-design-based-preparation-in-vitro-characterization-and-in-vivo-estimation-of-transcorneal-permeation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30660.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">449</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">40</span> Polymeric Micelles Based on Block Copolymer α-Tocopherol Succinate-g-Carboxymethyl Chitosan for Tamoxifen Delivery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sunil%20K.%20Jena">Sunil K. Jena</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjaya%20K.%20Samal"> Sanjaya K. Samal</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahesh%20Chand"> Mahesh Chand</a>, <a href="https://publications.waset.org/abstracts/search?q=Abhay%20T.%20Sangamwar"> Abhay T. Sangamwar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tamoxifen (TMX) and its analogues are approved as a first line therapy for the treatment of estrogen receptor-positive tumors. However, clinical development of TMX has been hampered by its low bioavailability and severe hepatotoxicity. Herein, we attempt to design a new drug delivery vehicle that could enhance the pharmacokinetic performance of TMX. Initially, high-molecular weight carboxymethyl chitosan was hydrolyzed to low-molecular weight carboxymethyl chitosan (LMW CMC) with hydrogen peroxide under the catalysis of phosphotungstic acid. Amphiphilic block copolymers of LMW CMC were synthesized via amidation reaction between the carboxyl group of α-tocopherol succinate (TS) and an amine group of LMW CMC. These amphiphilic block copolymers were self-assembled to nanosize core-shell-structural micelles in the aqueous medium. The critical micelle concentration (CMC) decreased with the increasing substitution of TS on LMW CMC, which ranged from 1.58 × 10-6 to 7.94 × 10-8 g/mL. Maximum TMX loading up to 8.08 ± 0.98% was achieved with Cmc-TS4.5 (TMX/Cmc-TS4.5 with 1:8 weight ratio). Both blank and TMX-loaded polymeric micelles (TMX-PM) of Cmc-TS4.5 exhibits spherical shape with the particle size below 200 nm. TMX-PM has been found to be stable in the gastrointestinal conditions and released only 44.5% of the total drug content by the first 72 h in simulated gastric fluid (SGF), pH 1.2. However, the presence of pepsin does not significantly increased the TMX release in SGF, pH 1.2, released only about 46.2% by the first 72 h suggesting its inability to cleave the peptide bond. In contrast, the release of TMX from TMX-PM4.5 in SIF, pH 6.8 (without pancreatin) was slow and sustained, released only about 10.43% of the total drug content within the first 30 min and nearly about 12.41% by the first 72 h. The presence of pancreatin in SIF, pH 6.8 led to an improvement in drug release. About 28.09% of incorporated TMX was released in the presence of pancreatin in 72 h. A cytotoxicity study demonstrated that TMX-PM exhibited time-delayed cytotoxicity in human MCF-7 breast cancer cells. Pharmacokinetic studies on Sprague-Dawley rats revealed a remarkable increase in oral bioavailability (1.87-fold) with significant (p < 0.0001) enhancement in AUC0-72 h, t1/2 and MRT of TMX-PM4.5 than that of TMX-suspension. Thus, the results suggested that CMC-TS micelles are a promising carrier for TMX delivery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carboxymethyl%20chitosan" title="carboxymethyl chitosan">carboxymethyl chitosan</a>, <a href="https://publications.waset.org/abstracts/search?q=d-%CE%B1-tocopherol%20succinate" title=" d-α-tocopherol succinate"> d-α-tocopherol succinate</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmacokinetic" title=" pharmacokinetic"> pharmacokinetic</a>, <a href="https://publications.waset.org/abstracts/search?q=polymeric%20micelles" title=" polymeric micelles"> polymeric micelles</a>, <a href="https://publications.waset.org/abstracts/search?q=tamoxifen" title=" tamoxifen"> tamoxifen</a> </p> <a href="https://publications.waset.org/abstracts/40966/polymeric-micelles-based-on-block-copolymer-a-tocopherol-succinate-g-carboxymethyl-chitosan-for-tamoxifen-delivery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40966.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">329</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">39</span> Charged Amphiphilic Polypeptide Based Micelle Hydrogel Composite for Dual Drug Release</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Monika%20Patel">Monika Patel</a>, <a href="https://publications.waset.org/abstracts/search?q=Kazuaki%20Matsumura"> Kazuaki Matsumura</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Synthetic hydrogels, with their unique properties such as porosity, strength, and swelling in aqueous environment, are being used in many fields from food additives to regenerative medicines, from diagnostic and pharmaceuticals to drug delivery systems (DDS). But, hydrogels also have some limitations in terms of homogeneity of drug distribution and quantity of loaded drugs. As an alternate, polymeric micelles are extensively used as DDS. With the ease of self-assembly, and distinct stability they remarkably improve the solubility of hydrophobic drugs. However, presently, combinational therapy is the need of time and so are systems which are capable of releasing more than one drug. And it is one of the major challenges towards DDS to control the release of each drug independently, which simple DDS cannot meet. In this work, we present an amphiphilic polypeptide based micelle hydrogel composite to study the dual drug release for wound healing purposes using Amphotericin B (AmpB) and Curcumin as model drugs. Firstly, two differently charged amphiphilic polypeptide chains were prepared namely, poly L-Lysine-b-poly phenyl alanine (PLL-PPA) and poly Glutamic acid-b-poly phenyl alanine (PGA-PPA) through ring opening polymerization of amino acid N-carboxyanhydride. These polymers readily self-assemble to form micelles with hydrophobic PPA block as core and hydrophilic PLL/PGA as shell with an average diameter of about 280nm. The thus formed micelles were loaded with the model drugs. The PLL-PPA micelle was loaded with curcumin and PGA-PPA was loaded with AmpB by dialysis method. Drug loaded micelles showed a slight increase in the mean diameter and were fairly stable in solution and lyophilized forms. For forming the micelles hydrogel composite, the drug loaded micelles were dissolved and were cross linked using genipin. Genipin uses the free –NH2 groups in the PLL-PPA micelles to form a hydrogel network with free PGA-PPA micelles trapped in between the 3D scaffold formed. Different composites were tested by changing the weight ratios of the both micelles and were seen to alter its resulting surface charge from positive to negative with increase in PGA-PPA ratio. The composites with high surface charge showed a burst release of drug in initial phase, were as the composites with relatively low net charge showed a sustained release. Thus the resultant surface charge of the composite can be tuned to tune its drug release profile. Also, while studying the degree of cross linking among the PLL-PPA particles for effect on dual drug release, it was seen that as the degree of crosslinking increases, an increase in the tendency to burst release the drug (AmpB) is seen in PGA-PPA particle, were as on the contrary the PLL-PPA particles showed a slower release of Curcumin with increasing the cross linking density. Thus, two different pharmacokinetic profile of drugs were seen by changing the cross linking degree. In conclusion, a unique charged amphiphilic polypeptide based micelle hydrogel composite for dual drug delivery. This composite can be finely tuned on the basis of need of drug release profiles by changing simple parameters such as composition, cross linking and pH. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amphiphilic%20polypeptide" title="amphiphilic polypeptide">amphiphilic polypeptide</a>, <a href="https://publications.waset.org/abstracts/search?q=dual%20drug%20release" title=" dual drug release"> dual drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=micelle%20hydrogel%20composite" title=" micelle hydrogel composite"> micelle hydrogel composite</a>, <a href="https://publications.waset.org/abstracts/search?q=tunable%20DDS" title=" tunable DDS"> tunable DDS</a> </p> <a href="https://publications.waset.org/abstracts/56879/charged-amphiphilic-polypeptide-based-micelle-hydrogel-composite-for-dual-drug-release" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/56879.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">207</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">38</span> Hydrophobically Modified Glycol Chitosan Nanoparticles as a Carrier for Etoposide</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Akhtar%20Aman">Akhtar Aman</a>, <a href="https://publications.waset.org/abstracts/search?q=Abida%20Raza"> Abida Raza</a>, <a href="https://publications.waset.org/abstracts/search?q=Shumaila%20Bashir"> Shumaila Bashir</a>, <a href="https://publications.waset.org/abstracts/search?q=Javaid%20Irfan"> Javaid Irfan</a>, <a href="https://publications.waset.org/abstracts/search?q=Andreas%20G.%20Sch%C3%A4tzlein"> Andreas G. Schätzlein</a>, <a href="https://publications.waset.org/abstracts/search?q=Ijeoma%20F%20Uchegbeu"> Ijeoma F Uchegbeu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Development of efficient delivery system for hydrophobic drugs remains a major concern in chemotherapy. The objective of the current study was to develop polymeric drug-delivery system for etoposide from amphiphilic derivatives of glycol chitosan, capable to improve the pharmacokinetics and to reduce the adverse effects of etoposide due to various organic solvents used in commercial formulations for solubilisation of etoposide. As a promising carrier, amphiphilic derivatives of glycol chitosan were synthesized by chemical grafting of palmitic acid N-hydroxy succinimide and quaternisation to glycol chitosan backbone. To this end a 7.9 kDa glycol chitosan was modified by palmitoylation and quaternisation into 13 kDa. Nano sized micelles prepared from this amphiphilic polymer had the capability to encapsulate up to 3 mg/ml etoposide. The pharmacokinetic results indicated that GCPQ based etoposide formulation transformed the biodistribution pattern. AUC 0.5-24 hr showed statistically significant difference in ETP-GCPQ vs. commercial preparation in liver (25 vs 70, p<0.001), spleen (27 vs. 36, P<0.05), lungs (42 vs. 136, p<0.001), kidneys (25 vs. 30, p<0.05) and brain (19 vs. 9,p<0.001). Using the hydrophobic fluorescent dye Nile red, we showed that micelles efficiently delivered their payload to MCF7 and A2780 cancer cells in-vitro and to A431 xenograft tumor in-vivo, suggesting these systems could deliver hydrophobic anti- cancer drugs such as etoposide to tumors. The pharmacokinetic results indicated that the GCPQ micelles transformed the biodistribution pattern and increased etoposide concentration in the brain significantly compared to free drug after intravenous administration. GCPQ based formulations not only reduced side effects associated with current available formulations but also increased their transport through the biological barriers, thus making it a good delivery system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=glycol%20chitosan" title="glycol chitosan">glycol chitosan</a>, <a href="https://publications.waset.org/abstracts/search?q=Nile%20red" title=" Nile red"> Nile red</a>, <a href="https://publications.waset.org/abstracts/search?q=micelles" title=" micelles"> micelles</a>, <a href="https://publications.waset.org/abstracts/search?q=etoposide" title=" etoposide"> etoposide</a>, <a href="https://publications.waset.org/abstracts/search?q=A431%20xenografts" title=" A431 xenografts"> A431 xenografts</a> </p> <a href="https://publications.waset.org/abstracts/15339/hydrophobically-modified-glycol-chitosan-nanoparticles-as-a-carrier-for-etoposide" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15339.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">310</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">37</span> Static Light Scattering Method for the Analysis of Raw Cow's Milk</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=V.%20Villa-Cruz">V. Villa-Cruz</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20P%C3%A9rez-Ladron%20de%20Guevara"> H. Pérez-Ladron de Guevara</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20E.%20Diaz-D%C3%ADaz"> J. E. Diaz-Díaz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Static Light Scattering (SLS) was used as a method to analyse cow's milk raw, coming from the town of Lagos de Moreno, Jalisco, Mexico. This method is based on the analysis of the dispersion of light laser produced by a set of particles in solution. Based on the above, raw milk, which contains particles of fat globules, with a diameter of 2000 nm and particles of micelles of protein with 300 nm in diameter were analyzed. For this, dilutions of commercial milk were made (1.0%, 2.0% and 3.3%) to obtain a pattern of laser light scattering and also made measurements of raw cow's milk. Readings were taken in a sweep initial angle 10° to 170°, results were analyzed with the program OriginPro 7. The SLS method gives us an estimate of the percentage of fat content in milk samples. It can be concluded that the SLS method, is a quick method of analysis to detect adulteration in raw cow's milk. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=light%20scattering" title="light scattering">light scattering</a>, <a href="https://publications.waset.org/abstracts/search?q=milk%20analysis" title=" milk analysis"> milk analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=adulteration%20in%20milk" title=" adulteration in milk"> adulteration in milk</a>, <a href="https://publications.waset.org/abstracts/search?q=micelles" title=" micelles"> micelles</a>, <a href="https://publications.waset.org/abstracts/search?q=OriginPro" title=" OriginPro "> OriginPro </a> </p> <a href="https://publications.waset.org/abstracts/28216/static-light-scattering-method-for-the-analysis-of-raw-cows-milk" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28216.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">375</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">36</span> Photophysics of a Coumarin Molecule in Graphene Oxide Containing Reverse Micelle</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aloke%20Bapli">Aloke Bapli</a>, <a href="https://publications.waset.org/abstracts/search?q=Debabrata%20Seth"> Debabrata Seth</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Graphene oxide (GO) is the two-dimensional (2D) nanoscale allotrope of carbon having several physiochemical properties such as high mechanical strength, high surface area, strong thermal and electrical conductivity makes it an important candidate in various modern applications such as drug delivery, supercapacitors, sensors etc. GO has been used in the photothermal treatment of cancers and Alzheimer’s disease etc. The main idea to choose GO in our work is that it is a surface active molecule, it has a large number of hydrophilic functional groups such as carboxylic acid, hydroxyl, epoxide on its surface and in basal plane. So it can easily interact with organic fluorophores through hydrogen bonding or any other kind of interaction and easily modulate the photophysics of the probe molecules. We have used different spectroscopic techniques for our work. The Ground-state absorption spectra and steady-state fluorescence emission spectra were measured by using UV-Vis spectrophotometer from Shimadzu (model-UV-2550) and spectrofluorometer from Horiba Jobin Yvon (model-Fluoromax 4P) respectively. All the fluorescence lifetime and anisotropy decays were collected by using time-correlated single photon counting (TCSPC) setup from Edinburgh instrument (model: LifeSpec-II, U.K.). Herein, we described the photophysics of a hydrophilic molecule 7-(n,n׀-diethylamino) coumarin-3-carboxylic acid (7-DCCA) in the reverse micelles containing GO. It was observed that photophysics of dye is modulated in the presence of GO compared to photophysics of dye in the absence of GO inside the reverse micelles. Here we have reported the solvent relaxation and rotational relaxation time in GO containing reverse micelle and compare our work with normal reverse micelle system by using 7-DCCA molecule. Normal reverse micelle means reverse micelle in the absence of GO. The absorption maxima of 7-DCCA were blue shifted and emission maxima were red shifted in GO containing reverse micelle compared to normal reverse micelle. The rotational relaxation time in GO containing reverse micelle is always faster compare to normal reverse micelle. Solvent relaxation time, at lower w₀ values, is always slower in GO containing reverse micelle compare to normal reverse micelle and at higher w₀ solvent relaxation time of GO containing reverse micelle becomes almost equal to normal reverse micelle. Here emission maximum of 7-DCCA exhibit bathochromic shift in GO containing reverse micelles compared to that in normal reverse micelles because in presence of GO the polarity of the system increases, as polarity increases the emission maxima was red shifted an average decay time of GO containing reverse micelle is less than that of the normal reverse micelle. In GO containing reverse micelle quantum yield, decay time, rotational relaxation time, solvent relaxation time at λₑₓ=375 nm is always higher than λₑₓ=405 nm, shows the excitation wavelength dependent photophysics of 7-DCCA in GO containing reverse micelles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=photophysics" title="photophysics">photophysics</a>, <a href="https://publications.waset.org/abstracts/search?q=reverse%20micelle" title=" reverse micelle"> reverse micelle</a>, <a href="https://publications.waset.org/abstracts/search?q=rotational%20relaxation" title=" rotational relaxation"> rotational relaxation</a>, <a href="https://publications.waset.org/abstracts/search?q=solvent%20relaxation" title=" solvent relaxation"> solvent relaxation</a> </p> <a href="https://publications.waset.org/abstracts/98137/photophysics-of-a-coumarin-molecule-in-graphene-oxide-containing-reverse-micelle" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/98137.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">155</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">35</span> Composite Coatings of Piezoelectric Quartz Sensors Based on Viscous Sorbents and Casein Micelles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shuba%20Anastasiia">Shuba Anastasiia</a>, <a href="https://publications.waset.org/abstracts/search?q=Kuchmenko%20Tatiana"> Kuchmenko Tatiana</a>, <a href="https://publications.waset.org/abstracts/search?q=Umarkhanov%20Ruslan"> Umarkhanov Ruslan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The development of new sensitive coatings for sensors is one of the key directions in the development of sensor technologies. Recently, there has been a trend towards the creation of multicomponent coatings for sensors, which make it possible to increase the sensitivity, and specificity, and improve the performance properties of sensors. When analyzing samples with a complex matrix of biological origin, the inclusion of micelles of bioactive substances (amino and nucleic acids, peptides, proteins) in the composition of the sensor coating can also increase useful analytical information. The purpose of this work is to evaluate the analytical characteristics of composite coatings of piezoelectric quartz sensors based on medium-molecular viscous sorbents with incorporated micellar casein concentrate during the sorption of vapors of volatile organic compounds. The sorption properties of the coatings were studied by piezoelectric quartz microbalance. Macromolecular compounds (dicyclohexyl-18-crown-6, triton X-100, lanolin, micellar casein concentrate) were used as sorbents. Highly volatile organic compounds of various classes (alcohols, acids, aldehydes, esters) and water were selected as test substances. It has been established that composite coatings of sensors with the inclusion of micellar casein are more stable and selective to vapors of highly volatile compounds than to water vapors. The method and technique of forming a composite coating using molecular viscous sorbents do not affect the kinetic features of VOC sorption. When casein micelles are used, the features of kinetic sorption depend on the matrix of the coating. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=piezoquartz%20sensor" title="piezoquartz sensor">piezoquartz sensor</a>, <a href="https://publications.waset.org/abstracts/search?q=viscous%20sorbents" title=" viscous sorbents"> viscous sorbents</a>, <a href="https://publications.waset.org/abstracts/search?q=micellar%20casein" title=" micellar casein"> micellar casein</a>, <a href="https://publications.waset.org/abstracts/search?q=coating" title=" coating"> coating</a>, <a href="https://publications.waset.org/abstracts/search?q=volatile%20compounds" title=" volatile compounds"> volatile compounds</a> </p> <a href="https://publications.waset.org/abstracts/163492/composite-coatings-of-piezoelectric-quartz-sensors-based-on-viscous-sorbents-and-casein-micelles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163492.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">122</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">34</span> Soybean Lecithin Based Reverse Micellar Extraction of Pectinase from Synthetic Solution</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sivananth%20Murugesan">Sivananth Murugesan</a>, <a href="https://publications.waset.org/abstracts/search?q=I.%20Regupathi"> I. Regupathi</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Vishwas%20Prabhu"> B. Vishwas Prabhu</a>, <a href="https://publications.waset.org/abstracts/search?q=Ankit%20Devatwal"> Ankit Devatwal</a>, <a href="https://publications.waset.org/abstracts/search?q=Vishnu%20Sivan%20Pillai"> Vishnu Sivan Pillai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Pectinase is an important enzyme which has a wide range of applications including textile processing and bioscouring of cotton fibers, coffee and tea fermentation, purification of plant viruses, oil extraction etc. Selective separation and purification of pectinase from fermentation broth and recover the enzyme form process stream for reuse are cost consuming process in most of the enzyme based industries. It is difficult to identify a suitable medium to enhance enzyme activity and retain its enzyme characteristics during such processes. The cost effective, selective separation of enzymes through the modified Liquid-liquid extraction is of current research interest worldwide. Reverse micellar extraction, globally acclaimed Liquid-liquid extraction technique is well known for its separation and purification of solutes from the feed which offers higher solute specificity and partitioning, ease of operation and recycling of extractants used. Surfactant concentrations above critical micelle concentration to an apolar solvent form micelles and addition of micellar phase to water in turn forms reverse micelles or water-in-oil emulsions. Since, electrostatic interaction plays a major role in the separation/purification of solutes using reverse micelles. These interaction parameters can be altered with the change in pH, addition of cosolvent, surfactant and electrolyte and non-electrolyte. Even though many chemical based commercial surfactant had been utilized for this purpose, the biosurfactants are more suitable for the purification of enzymes which are used in food application. The present work focused on the partitioning of pectinase from the synthetic aqueous solution within the reverse micelle phase formed by a biosurfactant, Soybean Lecithin dissolved in chloroform. The critical micelle concentration of soybean lecithin/chloroform solution was identified through refractive index and density measurements. Effect of surfactant concentrations above and below the critical micelle concentration was considered to study its effect on enzyme activity, enzyme partitioning within the reverse micelle phase. The effect of pH and electrolyte salts on the partitioning behavior was studied by varying the system pH and concentration of different salts during forward and back extraction steps. It was observed that lower concentrations of soybean lecithin enhanced the enzyme activity within the water core of the reverse micelle with maximizing extraction efficiency. The maximum yield of pectinase of 85% with a partitioning coefficient of 5.7 was achieved at 4.8 pH during forward extraction and 88% yield with a partitioning coefficient of 7.1 was observed during backward extraction at a pH value of 5.0. However, addition of salt decreased the enzyme activity and especially at higher salt concentrations enzyme activity declined drastically during both forward and back extraction steps. The results proved that reverse micelles formed by Soybean Lecithin and chloroform may be used for the extraction of pectinase from aqueous solution. Further, the reverse micelles can be considered as nanoreactors to enhance enzyme activity and maximum utilization of substrate at optimized conditions, which are paving a way to process intensification and scale-down. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pectinase" title="pectinase">pectinase</a>, <a href="https://publications.waset.org/abstracts/search?q=reverse%20micelles" title=" reverse micelles"> reverse micelles</a>, <a href="https://publications.waset.org/abstracts/search?q=soybean%20lecithin" title=" soybean lecithin"> soybean lecithin</a>, <a href="https://publications.waset.org/abstracts/search?q=selective%20partitioning" title=" selective partitioning"> selective partitioning</a> </p> <a href="https://publications.waset.org/abstracts/67512/soybean-lecithin-based-reverse-micellar-extraction-of-pectinase-from-synthetic-solution" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67512.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">372</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">33</span> Synthesis of a Hybrid of PEG-b-PCL and G1-PEA Dendrimer Based Six-Armed Star Polymer for Nano Delivery of Vancomycin</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Calvin%20A.%20Omolo">Calvin A. Omolo</a>, <a href="https://publications.waset.org/abstracts/search?q=Rahul%20S.%20Kalhapure"> Rahul S. Kalhapure</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahantesh%20Jadhav"> Mahantesh Jadhav</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjeev%20Rambharose"> Sanjeev Rambharose</a>, <a href="https://publications.waset.org/abstracts/search?q=Chunderika%20Mocktar"> Chunderika Mocktar</a>, <a href="https://publications.waset.org/abstracts/search?q=Thirumala%20Govender"> Thirumala Govender</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Treatment of infections is compromised by limitations of conventional dosage forms and drug resistance. Nanocarrier system is a strategy to overcome these challenges and improve therapy. Thus, the development of novel materials for drug delivery via nanocarriers is essential. The aim of the study was to synthesize a multi-arm polymer (6-mPEPEA) for enhanced activity of vancomycin (VM) against susceptible and resistant Staphylococcus aureus (MRSA). The synthesis steps of the star polymer followed reported procedures. The synthesized 6-mPEPEA was characterized by FTIR, ¹H and ¹³CNMR and MTT assays. VM loaded micelles were prepared from 6-mPEPEA and characterized for size, polydispersity index (PI) and surface charge (ZP) (Dynamic Light Scattering), morphology by TEM, drug loading (UV Spectrophotometry), drug release (dialysis bag), in vitro and in vivo efficacy against sensitive and resistant S. aureus. 6-mPEPEA was synthesized, and its structure was confirmed. MTT assays confirmed its nontoxic nature with a high cell viability (77%-85%). Unimolecular spherical micelles were prepared. Size, PI, and ZP was 52.48 ± 2.6 nm, 0.103 ± 0.047, -7.3 ± 1.3 mV, respectively and drug loading was 62.24 ± 3.8%. There was a 91% drug release from VCM-6-mPEPEA after 72 hours. In vitro antibacterial test revealed that VM-6-mPEPEA had 8 and 16-fold greater activity against S. aureus and MRSA when compared to bare VM. Further investigations using flow cytometry showed that VM-6-mPEPEA had 99.5% killing rate of MRSA at the MIC concentration. In vivo antibacterial activity revealed that treatment with VM-6-mPEPEA had a 190 and a 15-fold reduction in the MRSA load in untreated and VM treated respectively. These findings confirmed the potential of 6-mPEPEA as a promising bio-degradable nanocarrier for antibiotic delivery to improve treatment of bacterial infections. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biosafe" title="biosafe">biosafe</a>, <a href="https://publications.waset.org/abstracts/search?q=MRSA" title=" MRSA"> MRSA</a>, <a href="https://publications.waset.org/abstracts/search?q=nanocarrier" title=" nanocarrier"> nanocarrier</a>, <a href="https://publications.waset.org/abstracts/search?q=resistance" title=" resistance"> resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=unimolecular-micelles" title=" unimolecular-micelles"> unimolecular-micelles</a> </p> <a href="https://publications.waset.org/abstracts/82449/synthesis-of-a-hybrid-of-peg-b-pcl-and-g1-pea-dendrimer-based-six-armed-star-polymer-for-nano-delivery-of-vancomycin" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/82449.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">188</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">32</span> d-Block Metal Nanoparticles Confined in Triphenylphosphine Oxide Functionalized Core-Crosslinked Micelles for the Application in Biphasic Hydrogenation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=C.%20Joseph%20Abou-Fayssal">C. Joseph Abou-Fayssal</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Philippot"> K. Philippot</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Poli"> R. Poli</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Manoury"> E. Manoury</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Riisager"> A. Riisager</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The use of soluble polymer-supported metal nanoparticles (MNPs) has received significant attention for the ease of catalyst recovery and recycling. Of particular interest are MNPs that are supported on polymers that are either soluble or form stable colloidal dispersion in water, as this allows to combine of the advantages of the aqueous biphasic protocol with the catalytical performances of MNPs. The objective is to achieve good confinement of the catalyst in the nanoreactor cores and, thus, a better catalyst recovery in order to overcome the previously witnessed MNP extraction. Inspired by previous results, we are interested in the design of polymeric nanoreactors functionalized with ligands able to solidly anchor metallic nanoparticles in order to control the activity and selectivity of the developed nanocatalysts. The nanoreactors are core-crosslinked micelles (CCM) synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. Varying the nature of the core-linked functionalities allows us to get differently stabilized metal nanoparticles and thus compare their performance in the catalyzed aqueous biphasic hydrogenation of model substrates. Particular attention is given to catalyst recyclability. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biphasic%20catalysis" title="biphasic catalysis">biphasic catalysis</a>, <a href="https://publications.waset.org/abstracts/search?q=metal%20nanoparticles" title=" metal nanoparticles"> metal nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=polymeric%20nanoreactors" title=" polymeric nanoreactors"> polymeric nanoreactors</a>, <a href="https://publications.waset.org/abstracts/search?q=catalyst%20recovery" title=" catalyst recovery"> catalyst recovery</a>, <a href="https://publications.waset.org/abstracts/search?q=RAFT%20polymerization" title=" RAFT polymerization"> RAFT polymerization</a> </p> <a href="https://publications.waset.org/abstracts/158379/d-block-metal-nanoparticles-confined-in-triphenylphosphine-oxide-functionalized-core-crosslinked-micelles-for-the-application-in-biphasic-hydrogenation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/158379.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">100</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">31</span> Preparation of Magnetothermally Responsive Polymer Multilayer Films for Controlled Release Applications from Surfaces</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eda%20Cagli">Eda Cagli</a>, <a href="https://publications.waset.org/abstracts/search?q=Irem%20Erel%20Goktepe"> Irem Erel Goktepe</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Externally triggered and effective release of therapeutics from polymer nanoplatforms is one of the key issues in cancer treatment. In this study, we aim to prepare polymer multilayer films which are stable at physiological conditions (little or no drug release) but release drug molecules at acidic pH and via application of AC magnetic field. First, novel stimuli responsive diblock copolymers composed of pH- and temperature-responsive blocks were synthesized. Then, block copolymer micelles with pH-responsive core and temperature responsive coronae will be obtained via pH-induced self-assembly of these block copolymers in aqueous environment. A model anticancer drug, e.g. Doxorubicin will be loaded in the micellar cores. Second, superparamagnetic nanoparticles will be synthesized. Magnetic nanoparticles and drug loaded block copolymer micelles will be used as building blocks to construct the multilayers. To mimic the acidic nature of the tumor tissues, Doxorubicin release from the micellar cores will be induced at acidic conditions. Moreover, Doxorubicin release from the multilayers will be facilitated via magnetothermal trigger. Application of AC magnetic field will induce the heating of magnetic nanoparticles resulting in an increase in the temperature of the polymer platform. This increase in temperature is expected to trigger conformational changes on the temperature-responsive micelle coronae and facilitate the release of Doxorubicin from the surface. Such polymer platform may find use in biomedical applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=layer-by-layer%20films" title="layer-by-layer films">layer-by-layer films</a>, <a href="https://publications.waset.org/abstracts/search?q=magnetothermal%20trigger" title=" magnetothermal trigger"> magnetothermal trigger</a>, <a href="https://publications.waset.org/abstracts/search?q=smart%20polymers" title=" smart polymers"> smart polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=stimuli%20responsive" title=" stimuli responsive"> stimuli responsive</a> </p> <a href="https://publications.waset.org/abstracts/44684/preparation-of-magnetothermally-responsive-polymer-multilayer-films-for-controlled-release-applications-from-surfaces" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/44684.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">364</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">30</span> Nanopharmaceutical: A Comprehensive Appearance of Drug Delivery System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahsa%20Fathollahzadeh">Mahsa Fathollahzadeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The various nanoparticles employed in drug delivery applications include micelles, liposomes, solid lipid nanoparticles, polymeric nanoparticles, functionalized nanoparticles, nanocrystals, cyclodextrins, dendrimers, and nanotubes. Micelles, composed of amphiphilic block copolymers, can encapsulate hydrophobic molecules, allowing for targeted delivery. Liposomes, vesicular structures made up of phospholipids, can encapsulate both hydrophobic and hydrophilic molecules, providing a flexible platform for delivering therapeutic agents. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are designed to improve the stability and bioavailability of lipophilic drugs. Polymeric nanoparticles, such as poly(lactic-co-glycolic acid) (PLGA), are biodegradable and can be engineered to release drugs in a controlled manner. Functionalized nanoparticles, coated with targeting ligands or antibodies, can specifically target diseased cells or tissues. Nanocrystals, engineered to have specific surface properties, can enhance the solubility and bioavailability of poorly soluble drugs. Cyclodextrins, doughnut-shaped molecules with hydrophobic cavities, can be complex with hydrophobic molecules, allowing for improved solubility and bioavailability. Dendrimers, branched polymers with a central core, can be designed to deliver multiple therapeutic agents simultaneously. Nanotubes and metallic nanoparticles, such as gold nanoparticles, offer real-time tracking capabilities and can be used to detect biomolecular interactions. The use of these nanoparticles has revolutionized the field of drug delivery, enabling targeted and controlled release of therapeutic agents, reduced toxicity, and improved patient outcomes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanotechnology" title="nanotechnology">nanotechnology</a>, <a href="https://publications.waset.org/abstracts/search?q=nanopharmaceuticals" title=" nanopharmaceuticals"> nanopharmaceuticals</a>, <a href="https://publications.waset.org/abstracts/search?q=drug-delivery" title=" drug-delivery"> drug-delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=proteins" title=" proteins"> proteins</a>, <a href="https://publications.waset.org/abstracts/search?q=ligands" title=" ligands"> ligands</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=chemistry" title=" chemistry"> chemistry</a> </p> <a href="https://publications.waset.org/abstracts/186065/nanopharmaceutical-a-comprehensive-appearance-of-drug-delivery-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186065.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">51</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">29</span> Preliminary Studies on Poloxamer-Based Hydrogels with Oregano Essential Oil as Potential Topical Treatment of Cutaneous Papillomas</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ana%20Maria%20Mu%C8%9B">Ana Maria Muț</a>, <a href="https://publications.waset.org/abstracts/search?q=Georgeta%20Coneac"> Georgeta Coneac</a>, <a href="https://publications.waset.org/abstracts/search?q=Ioana%20Olariu"> Ioana Olariu</a>, <a href="https://publications.waset.org/abstracts/search?q=%C8%98tefana%20Avram"> Ștefana Avram</a>, <a href="https://publications.waset.org/abstracts/search?q=Ioana%20Zinuca%20Pavel"> Ioana Zinuca Pavel</a>, <a href="https://publications.waset.org/abstracts/search?q=Ionela%20Daliana%20Minda"> Ionela Daliana Minda</a>, <a href="https://publications.waset.org/abstracts/search?q=Lavinia%20Vlaia"> Lavinia Vlaia</a>, <a href="https://publications.waset.org/abstracts/search?q=Cristina%20Adriana%20Dehelean"> Cristina Adriana Dehelean</a>, <a href="https://publications.waset.org/abstracts/search?q=Corina%20Danciu"> Corina Danciu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Oregano essential oil is obtained from different parts of the plant Origanum vulgare (fam. Lamiaceae) and carvacrol and thymol are primary components, widely recognized for their antimicrobial activity, as well as their antiviral and antifungal properties. Poloxamers are triblock copolymers (Pluronic®), formed of three non-ionic blocks with a hydrophobic polyoxypropylene central chain flanked by two polyoxyethylene hydrophilic chains. They are known for their biocompatibility, sensitivity to temperature changes (sol-to-gel transition of aqueous solution with temperature increase), but also for their amphiphilic and surface active nature determining the formation of micelles, useful for solubilization of different hydrophobic compounds such as the terpenes and terpenoids contained in essential oils. Thus, these polymers, listed in European and US Pharmacopoeia and approved by FDA, are widely used as solubilizers and gelling agents for various pharmaceutical preparations, including topical hydrogels. The aim of this study was to investigate the posibility of solubilizing oregano essential oil (OEO) in polymeric micelles using polyoxypropylene (PPO)-polyoxyethylene (PEO)-polyoxypropylene (PPO) triblock polymers to obtain semisolid systems suitable for topical application. A formulation screening was performed, using Pluronic® F-127 in concentration of 20%, Pluronic® L-31, Pluronic® L-61 and Pluronic® L-62 in concentration of 0.5%, 0.8% respectively 1% to obtain the polymeric micelles-based systems. Then, to each selected system, with or without 10% absolute ethanol, 5% or 8% OEO was added. The obtained transparent poloxamer-based hydrogels containing solubilized OEO were further evaluated for pH, rheological characteristics (flow behaviour, viscosity, consistency and spreadability), using consacrated techniques like potentiometric titration, stationary shear flow test, penetrometric method and parallel plate method. Also, in vitro release and permeation of carvacrol from the hydrogels was carried out, using vertical diffusion cells and synthetic hydrophilic membrane and porcine skin respectively. The pH values and rheological features of all tested formulations were in accordance with official requirements for semisolid cutaneous preparations. But, the formulation containing 0.8% Pluronic® L-31, 10% absolute ethanol, 8% OEO and water and the formulation with 1% Pluronic® L-31, 5% OEO and water, produced the highest cumulative amounts of carvacrol released/permeated through the membrane. The present study demonstrated that oregano essential oil can be successfully solubilized in the investigated poloxamer-based hydrogels. These systems can be further investigated as potential topical therapy for cutaneous papillomas. Funding: This research was funded by Project PN-III-P1-1.1-TE2019-0130, Contract number TE47, Romania. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=oregano%20essential%20oil" title="oregano essential oil">oregano essential oil</a>, <a href="https://publications.waset.org/abstracts/search?q=carvacrol" title=" carvacrol"> carvacrol</a>, <a href="https://publications.waset.org/abstracts/search?q=poloxamer" title=" poloxamer"> poloxamer</a>, <a href="https://publications.waset.org/abstracts/search?q=topical%20hydrogels" title=" topical hydrogels"> topical hydrogels</a> </p> <a href="https://publications.waset.org/abstracts/150229/preliminary-studies-on-poloxamer-based-hydrogels-with-oregano-essential-oil-as-potential-topical-treatment-of-cutaneous-papillomas" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/150229.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">113</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">28</span> Re-Entrant Direct Hexagonal Phases in a Lyotropic System Induced by Ionic Liquids </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saheli%20Mitra">Saheli Mitra</a>, <a href="https://publications.waset.org/abstracts/search?q=Ramesh%20Karri"> Ramesh Karri</a>, <a href="https://publications.waset.org/abstracts/search?q=Praveen%20K.%20Mylapalli"> Praveen K. Mylapalli</a>, <a href="https://publications.waset.org/abstracts/search?q=Arka.%20B.%20Dey"> Arka. B. Dey</a>, <a href="https://publications.waset.org/abstracts/search?q=Gourav%20Bhattacharya"> Gourav Bhattacharya</a>, <a href="https://publications.waset.org/abstracts/search?q=Gouriprasanna%20Roy"> Gouriprasanna Roy</a>, <a href="https://publications.waset.org/abstracts/search?q=Syed%20M.%20Kamil"> Syed M. Kamil</a>, <a href="https://publications.waset.org/abstracts/search?q=Surajit%20Dhara"> Surajit Dhara</a>, <a href="https://publications.waset.org/abstracts/search?q=Sunil%20K.%20Sinha"> Sunil K. Sinha</a>, <a href="https://publications.waset.org/abstracts/search?q=Sajal%20K.%20Ghosh"> Sajal K. Ghosh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The most well-known structures of lyotropic liquid crystalline systems are the two dimensional hexagonal phase of cylindrical micelles with a positive interfacial curvature and the lamellar phase of flat bilayers with zero interfacial curvature. In aqueous solution of surfactants, the concentration dependent phase transitions have been investigated extensively. However, instead of changing the surfactant concentrations, the local curvature of an aggregate can be altered by tuning the electrostatic interactions among the constituent molecules. Intermediate phases with non-uniform interfacial curvature are still unexplored steps to understand the route of phase transition from hexagonal to lamellar. Understanding such structural evolution in lyotropic liquid crystalline systems is important as it decides the complex rheological behavior of the system, which is one of the main interests of the soft matter industry. Sodium dodecyl sulfate (SDS) is an anionic surfactant and can be considered as a unique system to tune the electrostatics by cationic additives. In present study, imidazolium-based ionic liquids (ILs) with different number of carbon atoms in their single hydrocarbon chain were used as the additive in the aqueous solution of SDS. At a fixed concentration of total non-aqueous components (SDS and IL), the molar ratio of these components was changed, which effectively altered the electrostatic interactions between the SDS molecules. As a result, the local curvature is observed to modify, and correspondingly, the structure of the hexagonal liquid crystalline phases are transformed into other phases. Polarizing optical microscopy of SDS and imidazole-based-IL systems have exhibited different textures of the liquid crystalline phases as a function of increasing concentration of the ILs. The small angle synchrotron x-ray diffraction (SAXD) study has indicated the hexagonal phase of direct cylindrical micelles to transform to a rectangular phase at the presence of short (two hydrocarbons) chain IL. However, the hexagonal phase is transformed to a lamellar phase at the presence of long (ten hydrocarbons) chain IL. Interestingly, at the presence of a medium (four hydrocarbons) chain IL, the hexagonal phase is transformed to another hexagonal phase of direct cylindrical micelles through the lamellar phase. To the best of our knowledge, such a phase sequence has not been reported earlier. Even though the small angle x-ray diffraction study has revealed the lattice parameters of these phases to be similar to each other, their rheological behavior has been distinctly different. These rheological studies have shed lights on how these phases differ in their viscoelastic behavior. Finally, the packing parameters, calculated for these phases based on the geometry of the aggregates, have explained the formation of the self-assembled aggregates. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lyotropic%20liquid%20crystals" title="lyotropic liquid crystals">lyotropic liquid crystals</a>, <a href="https://publications.waset.org/abstracts/search?q=polarizing%20optical%20microscopy" title=" polarizing optical microscopy"> polarizing optical microscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=rheology" title=" rheology"> rheology</a>, <a href="https://publications.waset.org/abstracts/search?q=surfactants" title=" surfactants"> surfactants</a>, <a href="https://publications.waset.org/abstracts/search?q=small%20angle%20x-ray%20diffraction" title=" small angle x-ray diffraction"> small angle x-ray diffraction</a> </p> <a href="https://publications.waset.org/abstracts/104719/re-entrant-direct-hexagonal-phases-in-a-lyotropic-system-induced-by-ionic-liquids" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/104719.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">138</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">27</span> Nanoparticles Made from PNIPAM-G-PEO Double Hydrophilic Copolymers for Temperature-Controlled Drug Delivery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Victoria%20I.%20Michailova">Victoria I. Michailova</a>, <a href="https://publications.waset.org/abstracts/search?q=Denitsa%20B.%20Momekova"> Denitsa B. Momekova</a>, <a href="https://publications.waset.org/abstracts/search?q=Hristiana%20A.%20Velichkova"> Hristiana A. Velichkova</a>, <a href="https://publications.waset.org/abstracts/search?q=Evgeni%20H.%20Ivanov"> Evgeni H. Ivanov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this work is to design and develop thermo-responsive nanosized drug delivery systems based on poly(N-isopropylacrylamide)-g-poly(ethylene oxide) (PNIPAM-g-PEO) double hydrophilic graft copolymers. The PNIPAM-g-PEO copolymers are able to self-assemble in water into nanoparticles above the LCST of the thermo-responsive PNIPAM backbone and to disassemble and rapidly release the entrapped drugs upon cooling. However, their drug delivery applications are often hindered by their low loading capacity as the drugs to be encapsulated do not dissolve in water. In order to overcome this limitation, here we applied a low-temperature procedure with ethanol as an alternative route to the formation and loading a model hydrophobic drug, Indomethacin (IMC), into PNIPAM-g-PEO nanoparticles. The rationale for this approach was that ethanol dissolves both IMC and the copolymer and its mixing with water may induce micellization of PNIPAM-g-PEO at temperatures lower than the LCST. The influence of the volume fraction of ethanol and the temperature on the aggregation characteristics of PNIPAM-g-PEO copolymers (2.7 mol% PEO) was investigated by means of DLS, TEM and rheological dynamic oscillatory tests. The studies showed rich phase behavior at T < LCST, incl. the formation of highly solvated 500-1000 nm complex structures, 30-70 nm micelles and polymersomes as well as giant polymersomes, as the fraction of added ethanol increased. We believe that the PNIPAM-g-PEO self-assembly is favored due to the different solvation of its constituting blocks in ethanol-water mixtures. The incorporation of IMC led to alteration of the physicochemical and morphological characteristics of the blank nanoparticles. In this case, only monodisperse polymersomes and micelles were observed in the solutions with an average diameter less than 65 nm and substantial drug loading (DLC ~117 – 146 wt%). Indomethacin release from the nanoparticles was responsive to temperature changes, being much faster at a temperature of 42oC compared to that of 37oC under otherwise the same conditions. The results obtained suggest that these PNIPAM-g-PEO nanoparticles could be potential in mild hyper-thermic delivery of nonsteroidal anti-inflammatory drugs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title="drug delivery">drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=poly%28N-isopropylacryl%20amide%29-g-poly%28ethylene%20oxide%29" title=" poly(N-isopropylacryl amide)-g-poly(ethylene oxide)"> poly(N-isopropylacryl amide)-g-poly(ethylene oxide)</a>, <a href="https://publications.waset.org/abstracts/search?q=thermo-responsive" title=" thermo-responsive"> thermo-responsive</a> </p> <a href="https://publications.waset.org/abstracts/47702/nanoparticles-made-from-pnipam-g-peo-double-hydrophilic-copolymers-for-temperature-controlled-drug-delivery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/47702.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">288</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">26</span> Superchaotropicity: Grafted Surface to Probe the Adsorption of Nano-Ions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Raimoana%20Frogier">Raimoana Frogier</a>, <a href="https://publications.waset.org/abstracts/search?q=Luc%20Girard"> Luc Girard</a>, <a href="https://publications.waset.org/abstracts/search?q=Pierre%20Bauduin"> Pierre Bauduin</a>, <a href="https://publications.waset.org/abstracts/search?q=Diane%20Rebiscoul"> Diane Rebiscoul</a>, <a href="https://publications.waset.org/abstracts/search?q=Olivier%20Diat"> Olivier Diat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nano-ions (NIs) are ionic species or clusters of nanometric size. Their low charge density and the delocalization of their charges give special properties to some of NIs belonging to chemical classes of polyoxometalates (POMs) or boron clusters. They have the particularity of interacting non-covalently with neutral hydrated surface or interfaces such as assemblies of surface-active molecules (micelles, vesicles, lyotropic liquid crystals), foam bubbles or emulsion droplets. This makes possible to classify those NIs in the Hofmeister series as superchaotropic ions. The mechanism of adsorption is complex, linked to the simultaneous dehydration of the ion and the molecule or supramolecular assembly with which it can interact, all with an enthalpic gain on the free energy of the system. This interaction process is reversible and is sufficiently pronounced to induce changes in molecular and supramolecular shape or conformation, phase transitions in the liquid phase, all at sub-millimolar ionic concentrations. This new property of some NIs opens up new possibilities for applications in fields as varied as biochemistry for solubilization, recovery of metals of interest by foams in the form of NIs... In order to better understand the physico-chemical mechanisms at the origin of this interaction, we use silicon wafers functionalized by non-ionic oligomers (polyethylene glycol chains or PEG) to study in situ by X-ray reflectivity this interaction of NIs with the grafted chains. This study carried out at ESRF (European Synchrotron Radiation Facility) and has shown that the adsorption of the NIs, such as POMs, has a very fast kinetics. Moreover the distribution of the NIs in the grafted PEG chain layer was quantify. These results are very encouraging and confirm what has been observed on soft interfaces such as micelles or foams. The possibility to play on the density, length and chemical nature of the grafted chains makes this system an ideal tool to provide kinetic and thermodynamic information to decipher the complex mechanisms at the origin of this adsorption. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adsorption" title="adsorption">adsorption</a>, <a href="https://publications.waset.org/abstracts/search?q=nano-ions" title=" nano-ions"> nano-ions</a>, <a href="https://publications.waset.org/abstracts/search?q=solid-liquid%20interface" title=" solid-liquid interface"> solid-liquid interface</a>, <a href="https://publications.waset.org/abstracts/search?q=superchaotropicity" title=" superchaotropicity"> superchaotropicity</a> </p> <a href="https://publications.waset.org/abstracts/165312/superchaotropicity-grafted-surface-to-probe-the-adsorption-of-nano-ions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165312.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">67</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25</span> Development of Micelle-Mediated Sr(II) Fluorescent Analysis System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Akutsu">K. Akutsu</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Mori"> S. Mori</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Hanashima"> T. Hanashima</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fluorescent probes are useful for the selective detection of trace amount of ions and biomolecular imaging in living cells. Various kinds of metal ion-selective fluorescent compounds have been developed, and some compounds have been applied as effective metal ion-selective fluorescent probes. However, because competition between the ligand and water molecules for the metal ion constitutes a major contribution to the stability of a complex in aqueous solution, it is difficult to develop a highly sensitive, selective, and stable fluorescent probe in aqueous solution. The micelles, these are formed in the surfactant aqueous solution, provides a unique hydrophobic nano-environment for stabilizing metal-organic complexes in aqueous solution. Therefore, we focused on the unique properties of micelles to develop a new fluorescence analysis system. We have been developed a fluorescence analysis system for Sr(II) by using a Sr(II) fluorescent sensor, N-(2-hydroxy-3-(1H-benzimidazol-2-yl)-phenyl)-1-aza-18-crown-6-ether (BIC), and studied its complexation behavior with Sr(II) in micellar solution. We revealed that the stability constant of Sr(II)-BIC complex was 10 times higher than that in aqueous solution. In addition, its detection limit value was also improved up to 300 times by this system. However, the mechanisms of these phenomena have remained obscure. In this study, we investigated the structure of Sr(II)-BIC complex in aqueous micellar solution by combining use the extended X-ray absorption fine structure (EXAFS) and neutron reflectivity (NR) method to understand the unique properties of the fluorescence analysis system from the view point of structural chemistry. EXAFS and NR experiments were performed on BL-27B at KEK-PF and on BL17 SHARAKU at J-PARC MLF, respectively. The obtained EXAFS spectra and their fitting results indicated that Sr(II) and BIC formed a Sr(18-crown-6-ether)-like complex in aqueous micellar solution. The EXAFS results also indicated that the hydrophilic head group of surfactant molecule was directly coordinated with Sr(II). In addition, the NR results also indicated that Sr(II)-BIC complex would interact with the surface of micelle molecules. Therefore, we concluded that Sr(II), BIC, and surfactant molecule formed a ternary complexes in aqueous micellar solution, and at least, it is clear that the improvement of the stability constant in micellar solution is attributed to the result of the formation of Sr(BIC)(surfactant) complex. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=micell" title="micell">micell</a>, <a href="https://publications.waset.org/abstracts/search?q=fluorescent%20probe" title=" fluorescent probe"> fluorescent probe</a>, <a href="https://publications.waset.org/abstracts/search?q=neutron%20reflectivity" title=" neutron reflectivity"> neutron reflectivity</a>, <a href="https://publications.waset.org/abstracts/search?q=EXAFS" title=" EXAFS"> EXAFS</a> </p> <a href="https://publications.waset.org/abstracts/79352/development-of-micelle-mediated-srii-fluorescent-analysis-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/79352.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">183</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=micelles&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=micelles&page=2" rel="next">&rsaquo;</a></li> </ul> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a 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