R＆D - GC Cell

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NK 세포는 종양 세포가 T 세포 공격을 회피하는 핵심 역할인 MHC-1(주조직적합성 복합체 1형) 결핍을 인식하여 종양 세포를 감지하고 퍼포린과 그랜자임을 방출하여 사멸시킵니다(Missing self). 반면 건강한 세포는 NK 세포의 면역억제수용체(KIR)와 MHC-1 간의 상호 작용을 통해 NK 세포 살해를 피할 수 있습니다. </p> </div> <div class="inbox inbox--small"> <h4>Mechanism of Action</h4> <div class="ourscience__mechanism"> <div class="ourscience__boxwrap"> <div class="ourscience__item" data-aos="fade"> <div class="ourscience__content"> <div class="ourscience__images"> <button type="button" class="enlarge-layer-open"> <img src="/resources/assets/images/mechanism_01.svg" alt="img" > </button> <button type="button" class="enlarge-layer-open"> <img src="/resources/assets/images/mechanism_02.svg" alt="img" > </button> </div> <div class="ourscience__bottomtitle">NK cell natural function</div> </div> </div> </div> <div class="ourscience__boxwrap"> <div class="ourscience__item" data-aos="fade"> <div class="ourscience__content"> <div class="ourscience__images"> <button type="button" class="enlarge-layer-open"> <img src="/resources/assets/images/mechanism_03.svg" alt="img" > </button> </div> <div class="ourscience__bottomtitle">Antibody dependent cellular cytotoxicity (ADCC)</div> </div> <p>NK 세포는 CD16(항체 인식 수용체)과 종양 항원 모두와 상호 작용하는 단일클론 항체 또는 NK 인게이저와 함께 ‘항체 의존성 세포 독성’ 작용을 통한 종양 세포를 사멸할 수 있습니다.</p> </div> <div class="ourscience__item" data-aos="fade"> <div class="ourscience__content"> <div class="ourscience__images"> <button type="button" class="enlarge-layer-open"> <img src="/resources/assets/images/mechanism_04.svg" alt="img" > </button> </div> <div class="ourscience__bottomtitle">CAR-mediated killing</div> </div> <p>CAR(키메라 항원 수용체)을 형질도입한 NK 세포는 종양 세포에서 과발현된 종양 특이적 항원을 표적으로 삼아 선택적으로 종양 세포를 사멸할 수 있습니다.</p> </div> </div> </div> </div> </div> </article> <article class="article" id="section03"> <div class="site-row"> <div class="inbox"> <h3 class="st-01">Cytokine-Induced Killer(CIK) Cell Therapy</h3> <p class="ko-large"> 세포 표면에 CD3와 CD56을 모두 발현하는 사이토카인 유도 살해(CIK) 세포는 종양 세포를 제거하는 강력한 자가유래 항암 면역세포치료제입니다. CIK 세포는 종양 특이적 항원에 대한 TCR(T 세포 수용체) 매개 뿐만 아니라 TCR 매개 없이도 종양 세포를 인식하고 파괴할 수 있습니다. CIK 세포치료제는 종양 세포에 대한 MHC(주조직적합성 복합체)의 제한 없이 높은 항암 활성을 보일 뿐만 아니라 높은 안전성을 기대할 수 있는 항암 면역세포치료제로 주목받고 있습니다. </p> </div> <div class="inbox inbox--small"> <h4>Mechanism of Action</h4> <div class="ourscience__mechanism"> <div class="ourscience__boxwrap"> <div class="ourscience__item" data-aos="fade"> <div class="ourscience__content"> <div class="ourscience__images"> <button type="button" class="enlarge-layer-open"> <img src="/resources/assets/images/mechanism_05.svg" alt="img" class="pcv" > <img src="/resources/assets/images/mechanism_05_mo.png" alt="img" class="mov" > </button> </div> </div> </div> </div> </div> </div> </div> </article> <article class="article" id="section04"> <div class="site-row"> <div class="sub-shapes pcv"> <span class="shapes shapes--science1"></span> </div> <div class="sub-shapes pcv"> <span class="shapes shapes--science2"></span> </div> <div class="inbox"> <h3 class="st-01">Cytotoxic T Lymphocytes(CTL) Cell Therapy</h3> <p class="ko-large"> 종양 특이적 항원을 인지하는 TCR을 가진 CD8 T 세포는 종양 세포에 존재하는 MHC-1을 인식하여 항암 활성을 나타냅니다. 종양 세포가 면역회피 기전으로 MHC-1을 숨길 경우 종양 특이적 CD8 T 세포는 항암 활성을 나타낼 수 없는데, 이러한 문제점을 극복하기 위해 키메라 항원 수용체(CAR)를 T 세포에 발현시킨 CAR-T 세포가 개발되어 MHC-1의 제한 없이 종양 세포를 사멸할 수 있습니다. </p> </div> <div class="inbox inbox--small"> <h4>Mechanism of Action</h4> <div class="ourscience__mechanism"> <div class="ourscience__boxwrap"> <div class="ourscience__item" data-aos="fade"> <div class="ourscience__content"> <div class="ourscience__images"> <button type="button" class="enlarge-layer-open"> <img src="/resources/assets/images/mechanism_06.svg" alt="img" > </button> </div> </div> </div> </div> </div> </div> </div> </article> </div> <div class="indicator"> <ul> <li> <a href="#section01" class="indicator__wrap"> </a> <div class="indicator__box"> <div class="indicator__text">GC Cell R&D</div> </div> </li> <li> <a href="#section02" class="indicator__wrap"> </a> <div class="indicator__box"> <div class="indicator__text">NK Cell Therapy</div> </div> </li> <li> <a href="#section03" class="indicator__wrap"> </a> <div class="indicator__box"> <div class="indicator__text">CIK Cell Therapy</div> </div> </li> <li> <a href="#section04" class="indicator__wrap"> </a> <div class="indicator__box"> <div class="indicator__text">T cell therapy</div> </div> </li> </ul> </div> </div>  <footer id="footer" class="footer">  <div class="go-top"> <div class="go-top__box go-top__box--contact"> <a href="/ko/etc/contactUs.do" class="go-contact-btn"> <span class="blind">Go contactUs</span> </a> </div> <div class="go-top__box go-top__box--top"></div> </div> <div class="footer__box"> <div class="site-row"> <div class="footer__top"> <span> <a href="/ko/main.do" class="logo"> <span class="blind">GC Cell</span> </a> </span> <div class="footer__information"> <div class="footer__infowrap"> <div class="item"> <b>주소</b> <p>경기도 용인시 기흥구 이현로30번길 107 (보정동) 지씨셀</p> </div> </div> <div class="footer__infowrap"> <div class="item"> <b>Tel</b> <p>+82-31-736-6700</p> </div> <div class="item"> <b>Fax</b> <p>+82-31-280-9959</p> </div> <div class="item"> <b>사업자등록번호</b> <p>142-81-37741</p> </div> </div> </div> <div class="footer__side"> <div class="family-site"> <button type="button" class="btn-family family-open"> <span>GC FAMILY SITE +</span> </button> </div> <ul class="footer-site"> <li><a href="https://recruit.gccorp.com/kor/main" target="_blank">채용 사이트</a></li> <li><a href="#" class="cookie-layer-open">쿠키 정책</a></li> <li><a href="/ko/etc/location.do">찾아오시는길</a></li> <li><a href="/ko/etc/privacy.do">개인정보처리방침</a></li> <li><a href="#" class="email-layer-open">이메일무단수집거부</a></li> </ul> </div> </div> </div> </div> <div class="footer__box"> <div class="site-row"> <div class="footer__bottom"> <p>Copyright ⓒ 2024 GC Cell. 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