CINXE.COM

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this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,x.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[R,S,Se,Ne,he,N,D,Pe,ke],loaderType:"pro"})})()})();</script> <meta name="keywords" content="" /> <link rel="canonical" href="https://www.novusbio.com/search?keywords=sox1" /> <title>Product Search for SOX1: Novus Biologicals</title> <meta name="description" content="Research reagents for SOX1. Find antibodies, kits, proteins, RNAi and other reagents all backed by our Guarantee+." /> <meta name="robots" content="noindex" /> <meta name="baidu-site-verification" content="xQr2vSIwwB" /> <script id="json-ld" type="application/ld+json">[{"@context":"http://schema.org","@type":"SearchResultsPage","about":[{"@type":"Thing","url":["https://www.novusbio.com/products/sox1-antibody_af3369"],"name":["SOX1 Antibody [Unconjugated]"],"image":[[{"@type":"ImageObject","caption":"Western blot shows lysates of undifferentiated iBJ6 human iPS cells and iBJ6 human iPS cells differentiated into neuroprogenitor cells. PVDF membrane was probed with 1 \u00b5g/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for SOX1 at approximately 39 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.","url":"https://images.novusbio.com/fullsize2/SOX1_AF3369_Western_Blot_21133.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"SOX1 was detected in immersion fixed BG01V human embryonic stem cells differentiated into neural progenitor cells using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 \u00b5g/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Nestin was also detected using Mouse Anti-Mouse/Rat Nestin Monoclonal Antibody (MAB2736) and stained using the NorthernLights™ 493-conjugated Anti-Mouse IgG Secondary Antibody (green; Catalog # NL009). Specific staining of SOX1 was localized to nuclei. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips.","url":"https://images.novusbio.com/fullsize2/SOX1_AF3369_Immunocytochemistry_13805.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"SOX1 was detected in immersion fixed NTera-2 human testicular embryonic carcinoma cell line differentiated with retinoic acid using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 \u00b5g/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 493-conjugated Anti-Goat IgG Secondary Antibody (green, upper panel; NL003) and counterstained with DAPI (blue, lower panel). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.","url":"https://images.novusbio.com/fullsize2/SOX1_AF3369_Immunocytochemistry_9786.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"SOX1 was detected in immersion fixed rat cortical stem cells (NSC001) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 \u00b5g/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.","url":"https://images.novusbio.com/fullsize2/SOX1_AF3369_Immunocytochemistry_12364.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"SOX1 was detected in immersion fixed mouse cortical stem cells (Catalog # NSC002) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 \u00b5g/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.","url":"https://images.novusbio.com/fullsize2/SOX1_AF3369_Immunocytochemistry_12365.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"SOX1 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei in neuron. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.","url":"https://images.novusbio.com/fullsize2/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-immunohistochemistry-19202111112.jpg","width":400,"height":400},{"@type":"ImageObject","caption":" Simple Western lane view shows lysates of undifferentiated iBJ6 human iPS cells andiBJ6 human iPS cells differentiated into neuroprogenitor cells, loaded at 0.2 mg/mL. A specific band was detected for SOX1 at approximately 50 kDa (as indicated) using 10 \u00b5g/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system. ","url":"https://images.novusbio.com/fullsize2/SOX1_AF3369_Simple_Western_21134.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Characterization of NSCs and cortical neurons derived from FKRP\u2010 and CRISPR/Cas9 corrected\u2010iPSCsA, BRepresentative images of NSCs derived from FKRP\u2010 and corrected\u2010iPSC lines expressing SOX1, SOX2, and nestin.C, DQuantification of percentage of SOX1+ (C) and SOX2+ (D) cells in culture. The efficiency of neural induction is more than 99% in FKRP\u2010 and corrected\u2010iPSC (5D17, 5D23, and 3B17) lines. Data are mean\u00a0\u00b1\u00a0s.d. n\u00a0=\u00a04 technical replicates.E, FFKRP\u2010 and corrected\u2010NSC lines can be further differentiated to cortical neural progenitor cells, expressing PAX6, OTX2, and vimentin.G\u2013IQuantification of percentage of PAX6+ (G) and OTX2+ (H) cells in culture. About 91\u201098% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express PAX6 (G). About 93\u201096% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express OTX2 (H). Of the OTX2+ population, about 60\u201067% cells are also Ki67+ cycling progenitors (I). Data are mean\u00a0\u00b1\u00a0s.d. n\u00a0=\u00a04 technical replicates.J, KGlutamatergic projection neurons derived from FKRP and corrected (5D17, 5D23, and 3B17) progenitor cells. The vast majority of neurons contain vGlut1+ punctae in their neurites (labeled by Tuj1). Right panels are enlarged images from the insets of left panels.Data information: Scale bars, 50\u00a0\u03bcm. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31566294), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-4120241048547.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Characterization of NSCs and cortical neurons derived from FKRP\u2010 and CRISPR/Cas9 corrected\u2010iPSCsA, BRepresentative images of NSCs derived from FKRP\u2010 and corrected\u2010iPSC lines expressing SOX1, SOX2, and nestin.C, DQuantification of percentage of SOX1+ (C) and SOX2+ (D) cells in culture. The efficiency of neural induction is more than 99% in FKRP\u2010 and corrected\u2010iPSC (5D17, 5D23, and 3B17) lines. Data are mean\u00a0\u00b1\u00a0s.d. n\u00a0=\u00a04 technical replicates.E, FFKRP\u2010 and corrected\u2010NSC lines can be further differentiated to cortical neural progenitor cells, expressing PAX6, OTX2, and vimentin.G\u2013IQuantification of percentage of PAX6+ (G) and OTX2+ (H) cells in culture. About 91\u201098% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express PAX6 (G). About 93\u201096% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express OTX2 (H). Of the OTX2+ population, about 60\u201067% cells are also Ki67+ cycling progenitors (I). Data are mean\u00a0\u00b1\u00a0s.d. n\u00a0=\u00a04 technical replicates.J, KGlutamatergic projection neurons derived from FKRP and corrected (5D17, 5D23, and 3B17) progenitor cells. The vast majority of neurons contain vGlut1+ punctae in their neurites (labeled by Tuj1). Right panels are enlarged images from the insets of left panels.Data information: Scale bars, 50\u00a0\u03bcm. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31566294), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-41202410485410.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Expression of NSUN2 in the Human Developing Brain and NES Cells(A) DAPI-stained human embryo (6\u00a0weeks of gestation) marked for prosencephalon, mesencephalon, and rhombencephalon. Region in square is magnified in (B). Scale bar, 1\u00a0mm.(B) Prosencephalon labeled for NSUN2 and SOX1. Region in squares are magnified in (b\u2032) and (b\u2033). Arrows indicate NSUN2-positive cells. Scale bar, 100\u00a0\u03bcm.(C\u2013F) Bright-field image (C) and immunofluorescence (D\u2013F) of AF22 (upper panels) and Sai1 (lower panels) cells labeled for Nestin (D), SOX2 (E), and beta III-tubulin (F). Scale bar, 50\u00a0\u03bcm.(G and H) NES cells co-labeled for NSUN2 and Nestin (NES) (G) or SOX1 (H).(I) Differentiation protocol.(J\u2013L) Differentiated AF22 and Sai1 cells (day 15) labeled for Nestin (NES; J), SOX2 (K), and beta III-tubulin (L). Scale bars: 50\u00a0\u03bcm.(M) Western blot for NSUN2, beta III-tubulin (TUBB3), GFAP, SOX2, and Nestin during differentiation (days). alpha -Tubulin served as loading control.Nuclei are counterstained with DAPI (A, B, D\u2013F, J\u2013L). Image collected and cropped by CiteAb from the following publication (//linkinghub.elsevier.com/retrieve/pii/S2213671116302764), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-4120241048241.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Expression of NSUN2 in the Human Developing Brain and NES Cells(A) DAPI-stained human embryo (6\u00a0weeks of gestation) marked for prosencephalon, mesencephalon, and rhombencephalon. Region in square is magnified in (B). Scale bar, 1\u00a0mm.(B) Prosencephalon labeled for NSUN2 and SOX1. Region in squares are magnified in (b\u2032) and (b\u2033). Arrows indicate NSUN2-positive cells. Scale bar, 100\u00a0\u03bcm.(C\u2013F) Bright-field image (C) and immunofluorescence (D\u2013F) of AF22 (upper panels) and Sai1 (lower panels) cells labeled for Nestin (D), SOX2 (E), and beta III-tubulin (F). Scale bar, 50\u00a0\u03bcm.(G and H) NES cells co-labeled for NSUN2 and Nestin (NES) (G) or SOX1 (H).(I) Differentiation protocol.(J\u2013L) Differentiated AF22 and Sai1 cells (day 15) labeled for Nestin (NES; J), SOX2 (K), and beta III-tubulin (L). Scale bars: 50\u00a0\u03bcm.(M) Western blot for NSUN2, beta III-tubulin (TUBB3), GFAP, SOX2, and Nestin during differentiation (days). alpha -Tubulin served as loading control.Nuclei are counterstained with DAPI (A, B, D\u2013F, J\u2013L). Image collected and cropped by CiteAb from the following publication (//linkinghub.elsevier.com/retrieve/pii/S2213671116302764), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-41202410482417.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"GPI anchored proteins are required for neural differentiation.(A). Representative example of images of hiPSC-derived EBs and EB-derived rosettes during neural differentiation. Neural induction and rosette formation upon neural induction was assessed in three cell lines using a serum-free EB generation method. On day 2 (left) of hiPSC-derived EBs from PIGAwt, PIGAc.1234C>T, and PIGAnull after forced aggregation (20X magnification, scale bar is 50\u03bcm). On day 4 (middle), single homogeneous hiPSC-EBs collected were pooled in a 10 cm plate (4X magnification, scale bar is 100\u03bcm). On day 11 (right), neuroepithelial cells appeared and neural tube-like rosettes formed (EB-derived rosettes) and scale bar is 50\u03bcm. (B). Neural induction rates from EB-derived rosettes. The percentage of EB derived rosettes was 88.8% \u00b1 4.6, 75.5% \u00b1 9.8 and 68.4% \u00b1 6.9 for PIGAwt, PIGAc.1234C>T, and PIGAnull, respectively. PIGAwt versus PIGAc.1234C>T (p>0.05, NS) and PIGAwt versus PIGAnull (*pT compared to PIGAwt. (F). Graphs depict the percentage of positive cells for SOX-1 (left) and Pax6 (right) in hNPCs derived from PIGAwt, PIGAc.1234C>T, and PIGAnull hiPSC lines. The hNPCs derived from the PIGAnull hiPSCs showed significantly decreased expression of SOX1 and PAX6. Similar levels of SOX1 and PAX6 were expressed in hNPCs from PIGAwt and PIGAc.1234C>T. All values represent mean \u00b1 SD. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0174074), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-41202410485430.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/sox1-antibody_nbp2-24486"],"name":["SOX1 Antibody"],"image":[[{"@type":"ImageObject","caption":"Western Blot: SOX1 Antibody [NBP2-24486] - Analysis of extracts from mouse brain using SOX1 antibody (NBP2-24486, 1:100). Image from verified customer review.","url":"https://images.novusbio.com/fullsize/SOX1-Antibody-Western-Blot-NBP2-24486-img0005.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Western Blot: SOX1 Antibody [NBP2-24486] - Analysis of SOX1 in human brain lysate in the 1) absence and 2) presence of immunizing peptide. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.","url":"https://images.novusbio.com/fullsize/SOX1-Antibody-Western-Blot-NBP2-24486-img0003.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Western Blot: SOX1 Antibody [NBP2-24486] - Analysis in D3 cell lysate in the 1) absence and 2) presence of immunizing peptide using NBP2-24486 at 1 ug/mL. Goat anti-rabbit Ig HRP secondary antibody (Novus, 20301) and PicoTect ECL substrate solution (Novus, 10087K) were used.","url":"https://images.novusbio.com/fullsize/SOX1-Antibody-Western-Blot-NBP2-24486-img0004.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/sox9-antibody_af3075"],"name":["SOX9 Antibody [Unconjugated]"],"image":[[{"@type":"ImageObject","caption":"Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, KATO-III human gastric carcinoma cell line, COLO 205 human colorectal adenocarcinoma cell line, and Hep3B human hepatocellular carcinoma cell line. PVDF membrane was probed with 0.5 \u00b5g/mL of Goat Anti-Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for SOX9 at approximately 75 kDa (as indicated). GAPDH (Catalog # AF5718) is shown as a loading control. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.","url":"https://images.novusbio.com/fullsize2/SOX9_AF3075_Western_Blot_21580.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"SOX9 was detected in immersion fixed HEK293 human embryonic kidney cell line using 10 µg/mL Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.","url":"https://images.novusbio.com/fullsize2/SOX9_AF3075_Immunocytochemistry_6490.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"SOX9 was detected in immersion fixed BG01V human embryonic stem cells differentiated into early proximal lung progenitor cells using Goat Anti-Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) at 10 \u00b5g/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips.","url":"https://images.novusbio.com/fullsize2/SOX9_AF3075_Immunocytochemistry_15995.jpg","width":400,"height":400},{"@type":"ImageObject","caption":" Simple Western lane view shows lysates of normal adjacent tissue and Crohns tissue, loaded at 0.2 mg/mL. A specific band was detected for SOX9 at approximately 107 kDa (as indicated) using 20 \u00b5g/mL of Goat Anti-Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system. ","url":"https://images.novusbio.com/fullsize2/SOX9_AF3075_Simple_Western_22563.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Comparison of E12.5 Sox9IE/IE and Sox9FE/FE embryos based on EGFP intensity and Western blotting.(A) Left panel: white light images of E12.5 Sox9IE/IE and Sox9FE/FE embryos; right panel: same embryos imaged by fluorescence microscopy showed a higher EGFP fluorescence in the Sox9FE/FE embryo compared to the Sox9IE/IE embryo, with EGFP expression in Sox9-specific domains in both. (B) Mean overall EGFP fluorescence of E12.5 Sox9IE/IE (13880.04\u00b11015.55; n\u200a=\u200a8) and Sox9FE/FE (84579.48\u00b12822.09; n\u200a=\u200a4) embryos analyzed by flow cytometry. Overall EGFP fluorescence was calculated by multiplying the MFI and percentage of EGFP-positive cells. Two-tailed Student's T test, ***p<0.0001. (C) Western blot analysis of E12.5 Sox9IE/IE and Sox9FE/FE embryo lysates, resolved on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) gels and immunoblotted with anti-Sox9 (upper panel) and anti-GFP (middle panel) antibodies. In the upper panel, Sox9-EGFP fusion protein and Sox9-2A (2A - residual 23 amino acids of F2A) was only detected in the Sox9FE/FE embryo lysate, but not in the CD-1 WT or Sox9IE/IE embryo lysates. Middle panel: Sox9-EGFP fusion protein was not detected in the Sox9FE/FE embryos but EGFP was detected in both the Sox9IE/IE and Sox9FE/FE lysates at predicted molecular weight. CD-1 WT lysate served as negative control for EGFP. Bottom panel: immunoblotting with anti-histone antibody showed equal loading. WT \u2013 wild-type. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0028885), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-4120241032148.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Dbx1\u2010expressing progenitors give rise to preB\u00f6tC neurons and glia. A. Confocal images of Dbx1CreERT2; Rosa26tdTomato mouse preB\u00f6tC sections immunostained for NeuN. Dbx1\u2010derived neurons (white arrowhead) expressed tdTomato and were immunoreactive for NeuN. Dbx1\u2010derived glia (gray arrowhead) expressed tdTomato and were not immunoreactive for NeuN. B. Confocal images of Dbx1CreERT2; Rosa26tdTomato mouse preB\u00f6tC sections 72\u00a0h after injection with AAV\u2010hSyn\u2010GFP. Dbx1\u2010derived non\u2010neuronal cells extend diffuse fibrils that are closely apposed to the outer surface of microvasculature (white arrows). C, Confocal images of Dbx1CreERT2; Rosa26tdTomato mouse preB\u00f6tC sections immunostained for Sox9. Glia (gray arrowheads) were immunoreactive for Sox9. Dbx1\u2010derived neurons (white arrowhead) expressed tdTomato but were not immunoreactive for Sox9. Dbx1\u2010derived glia expressed tdTomato and were immunoreactive for Sox9 (see \u201coverlay\u201d panel). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28611151), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410325582.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Feeder-free expansion of SOX9+ BCs. (A) Immunostaining of SOX9+ BCs with anti-P63, anti-KRT5 and anti-SOX9 antibodies. (B) SOX9+ BCs in rugae of 3rd order human airway by anti-SOX9, anti-P63 and anti-CC10 immunostaining. Scale bar, 100 \u03bcm. (C) SOX9+ BCs in rugae of 3rd order human airway by anti-KI67 immunostaining. (D) BC colony cultured on feeder-free condition. (E) Karyotyping of cultured BCs. (F) qPCR showing alveolar and bronchial epithelium marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (G) qPCR showing progenitor cell marker (Krt5, P63 and SOX9) gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (H) Western blotting showing marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-4120241033837.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Transplantated SOX9+ BCs regenerate functional human lungin vivo. (A) Left, direct fluorescence image under stereomicroscope showing NOD-SCID mouse lung without (upper panel) or with (lower panel) GFP-labeled SOX9+ BC transplantation. Right, cryo-section and direct fluorescence imaging of transplanted GFP-labeled SOX9+ BCs in lung parenchyma. Scale bar, 100 \u03bcm. (B) Immunofluorescence imaging of transplanted GFP-labeled SOX9+ BCs in lung parenchyma with human specific Lamin A+C marker costaining. (C) Fully differentiated GFP+ cells lost SOX9 marker expression (arrowhead indicated). Scale bar, 10 \u03bcm. (D) Confocal image with human specific Lamin A+C immunostaining (HuLamin) showing regenerated type I (AQP5+) alveolar cells. No type II (SPC+) cells were observed. (E) Confocal image showing regenerated AEC1 (AQP5+ and HOPX+). AQP5 as a membrane-bound protein distributes on surface of GFP+ cells. Arrowheads indicated the overlay of HOPX with GFP signal in nucleus. Scale bar, 20 \u03bcm. (F) qPCR with human specific primers showing alveolar and bronchiolar epithelium marker gene expression in SOX9+ BC transplanted chimeric lung (AEC1: AQP5 and HOPX; AEC2: SPB and LAMP3; bronchiolar cells: SCGB1A1 and MUC1). Biological replicates, n = 3. Error bars, S.E.M. (G) Left, clonogenic BCs isolated from human cervix epithelium obtained by biopsy. Right, transplantation of equal numbers of BCs from lung and cervix indicated different incorporation efficiency Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410333016.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Feeder-free expansion of SOX9+ BCs. (A) Immunostaining of SOX9+ BCs with anti-P63, anti-KRT5 and anti-SOX9 antibodies. (B) SOX9+ BCs in rugae of 3rd order human airway by anti-SOX9, anti-P63 and anti-CC10 immunostaining. Scale bar, 100 \u03bcm. (C) SOX9+ BCs in rugae of 3rd order human airway by anti-KI67 immunostaining. (D) BC colony cultured on feeder-free condition. (E) Karyotyping of cultured BCs. (F) qPCR showing alveolar and bronchial epithelium marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (G) qPCR showing progenitor cell marker (Krt5, P63 and SOX9) gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (H) Western blotting showing marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410333024.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Feeder-free expansion of SOX9+ BCs. (A) Immunostaining of SOX9+ BCs with anti-P63, anti-KRT5 and anti-SOX9 antibodies. (B) SOX9+ BCs in rugae of 3rd order human airway by anti-SOX9, anti-P63 and anti-CC10 immunostaining. Scale bar, 100 \u03bcm. (C) SOX9+ BCs in rugae of 3rd order human airway by anti-KI67 immunostaining. (D) BC colony cultured on feeder-free condition. (E) Karyotyping of cultured BCs. (F) qPCR showing alveolar and bronchial epithelium marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (G) qPCR showing progenitor cell marker (Krt5, P63 and SOX9) gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (H) Western blotting showing marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410325531.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Evolution of alveolar epithelial gene expression patterns in the developing mouse lung. Sections of E15.5, 16.5, 17.5 and 18.5 wild-type mouse lungs stained for markers of differentiation. (A) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, LPCAT1 (tip cells from E16.5, then AT2 cells). (B) Green, CEBPA (sub-set of tip cells from E16.5, then AT2 cells); red, pro-SFTPC (embryonic epithelium, stronger from E16.5, later specific to AT2 cells). (C) Green, pro-SFTPC (stronger from E16.5, later specific to AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (D) Green, LPCAT1 (tip cells from E16.5, then AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (E) Green, HOPX (stalk cells from E16.5, AT1 cells); red, SOX9 (tip cells); white, E-CAD (epithelial cells). (F) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, HOPX (stalk cells from E16.5, AT1 cells). (G) Green, HOPX (stalk cells from E16.5, AT1 cells); red, LPCAT1 (tip cells from E16.5, then AT2 cells). Arrows, LPCAT1+ HOPX+ cells; arrowheads, LPCAT1+ HOPX\u2212 cells. Blue, DAPI (nuclei). Dashed line, edge of lung. Scale bars: 50\u2005\u03bcm in A-F, 20\u2005\u03bcm in G and insets. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721191.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Glucocorticoid signalling is sufficient, but not essential, to specify alveolar fate. (A) Experimental design: Tomato+ E12.5 or 16.5 tip or stalk was grafted into E12.5 host lung and grown with 50\u2005nM Dx throughout culture. (B) Examples of alveolar-fated tip grafts stained for: green, LPCAT1 (alveolar fate); red, Tomato (graft); white, PDPN (basal and AT1 cells). Arrowheads, PDPN+ AT1 cells. (C) Split bar graph showing results from B. Each type of graft was analysed in at least three independent experiments. (D) E12.5 wild-type lungs were grown with or without Dx for up to 6\u2005days; two independent experimental replicates. Note precocious expression of alveolar markers in the presence of Dx. Lungs cultured without Dx do express LPCAT1 from experimental day\u00a05. Green, LPCAT1 (late tip progenitors and type 2 cells); red, SOX9 (tip progenitors). (E,F) Sections of GR\u2212/\u2212 and GR+/+ sibling lungs at E17.5 and E18.5 stained for: green, HOPX (AT1 cells); red, SOX9 (tip progenitors); white, E-CAD (epithelium) (E), and: green, LPCAT1 (late tip progenitors and AT2 cells); red, LAMP3 (AT2 cells); magenta, PDPN (late tip progenitors and AT1 cells) (F). A total of five GR\u2212/\u2212 and 5 GR+/+ sibling lungs from three independent litters were observed at both E17.5 and E18.5. Blue, DAPI. Dashed line, edge of lung. Scale bars: 100\u2005\u03bcm in B; 50\u2005\u03bcm in D-F. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721165.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Evolution of alveolar epithelial gene expression patterns in the developing mouse lung. Sections of E15.5, 16.5, 17.5 and 18.5 wild-type mouse lungs stained for markers of differentiation. (A) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, LPCAT1 (tip cells from E16.5, then AT2 cells). (B) Green, CEBPA (sub-set of tip cells from E16.5, then AT2 cells); red, pro-SFTPC (embryonic epithelium, stronger from E16.5, later specific to AT2 cells). (C) Green, pro-SFTPC (stronger from E16.5, later specific to AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (D) Green, LPCAT1 (tip cells from E16.5, then AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (E) Green, HOPX (stalk cells from E16.5, AT1 cells); red, SOX9 (tip cells); white, E-CAD (epithelial cells). (F) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, HOPX (stalk cells from E16.5, AT1 cells). (G) Green, HOPX (stalk cells from E16.5, AT1 cells); red, LPCAT1 (tip cells from E16.5, then AT2 cells). Arrows, LPCAT1+ HOPX+ cells; arrowheads, LPCAT1+ HOPX\u2212 cells. Blue, DAPI (nuclei). Dashed line, edge of lung. Scale bars: 50\u2005\u03bcm in A-F, 20\u2005\u03bcm in G and insets. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721139.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Glucocorticoid signalling is sufficient, but not essential, to specify alveolar fate. (A) Experimental design: Tomato+ E12.5 or 16.5 tip or stalk was grafted into E12.5 host lung and grown with 50\u2005nM Dx throughout culture. (B) Examples of alveolar-fated tip grafts stained for: green, LPCAT1 (alveolar fate); red, Tomato (graft); white, PDPN (basal and AT1 cells). Arrowheads, PDPN+ AT1 cells. (C) Split bar graph showing results from B. Each type of graft was analysed in at least three independent experiments. (D) E12.5 wild-type lungs were grown with or without Dx for up to 6\u2005days; two independent experimental replicates. Note precocious expression of alveolar markers in the presence of Dx. Lungs cultured without Dx do express LPCAT1 from experimental day\u00a05. Green, LPCAT1 (late tip progenitors and type 2 cells); red, SOX9 (tip progenitors). (E,F) Sections of GR\u2212/\u2212 and GR+/+ sibling lungs at E17.5 and E18.5 stained for: green, HOPX (AT1 cells); red, SOX9 (tip progenitors); white, E-CAD (epithelium) (E), and: green, LPCAT1 (late tip progenitors and AT2 cells); red, LAMP3 (AT2 cells); magenta, PDPN (late tip progenitors and AT1 cells) (F). A total of five GR\u2212/\u2212 and 5 GR+/+ sibling lungs from three independent litters were observed at both E17.5 and E18.5. Blue, DAPI. Dashed line, edge of lung. Scale bars: 100\u2005\u03bcm in B; 50\u2005\u03bcm in D-F. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721128.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Evolution of alveolar epithelial gene expression patterns in the developing mouse lung. Sections of E15.5, 16.5, 17.5 and 18.5 wild-type mouse lungs stained for markers of differentiation. (A) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, LPCAT1 (tip cells from E16.5, then AT2 cells). (B) Green, CEBPA (sub-set of tip cells from E16.5, then AT2 cells); red, pro-SFTPC (embryonic epithelium, stronger from E16.5, later specific to AT2 cells). (C) Green, pro-SFTPC (stronger from E16.5, later specific to AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (D) Green, LPCAT1 (tip cells from E16.5, then AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (E) Green, HOPX (stalk cells from E16.5, AT1 cells); red, SOX9 (tip cells); white, E-CAD (epithelial cells). (F) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, HOPX (stalk cells from E16.5, AT1 cells). (G) Green, HOPX (stalk cells from E16.5, AT1 cells); red, LPCAT1 (tip cells from E16.5, then AT2 cells). Arrows, LPCAT1+ HOPX+ cells; arrowheads, LPCAT1+ HOPX\u2212 cells. Blue, DAPI (nuclei). Dashed line, edge of lung. Scale bars: 50\u2005\u03bcm in A-F, 20\u2005\u03bcm in G and insets. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241723625.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Validation of stem cell associated proteins after HGF stimulation.A, FACS demonstrated up-regulation of CD49b (240%), CD49f (22%), CD44 (26%), together with down-regulation of CD24 (\u221269%) after HGF stimulation. Thin gray line represents labelling with secondary antibody only (negative control), thin black line DU145 without HGF, and thick black line DU145 with HGF. B, Western blot showed enhancement of SOX9 expression upon HGF stimulation from 2 to 24 hours. C, FACS demonstrated induction of double-labelled CD44+/CD24\u2212 DU145 cells (control 8% versus HGF 26%). Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/22110593), licensed under a CC-BY license. Not internally tested by R&D Systems.","url":"https://images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-812025557255.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/sox9-antibody-cl0639_nbp2-52943"],"name":["SOX9 Antibody (CL0639)"],"image":[[{"@type":"ImageObject","caption":"Western Blot: SOX9 Antibody (CL0639) [NBP2-52943] - 251 Cells transfected with: control siRNA, target specific siRNA probe #1, target specific siRNA probe #2, using Anti-SOX9 monoclonal antibody. Downregulation of antibody signal confirms target specificity. Remaining % intensity, relative control lane, is indicated. Anti-GAPDH monoclonal antibody was used as loading control.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Western-Blot-NBP2-52943-img0011.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Analysis in human cerebral cortex and liver tissues using NBP2-52943antibody. Corresponding SOX9 RNA-seq data are presented for the same tissues.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0018.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunocytochemistry/Immunofluorescence: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of U-251 cells using the anti-SOX9 monoclonal antibody, showing specific staining in the nucleoplasm in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available). Antibody staining is shown in green.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunocytochemistry-Immunofluorescence-NBP2-52943-img0016.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of human liver shows no nuclear positivity in hepatocytes as expected.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0021.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of mouse embryo E11 shows nuclear positivity in the developing neural tube.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-NBP2-52943-img0013.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of mouse embryo E14 shows nuclear immunoreactivity in the developing eye.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-NBP2-52943-img0014.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of human cerebral cortex shows moderate to strong nuclear positivity in a subset of glial cells. ","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0019.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of human testis shows strong nuclear positivity in a subset of cells in seminiferious ducts.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0020.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/sox9-antibody_nbp1-85551"],"name":["SOX9 Antibody"],"image":[[{"@type":"ImageObject","caption":"Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining in human testis and skeletal muscle tissues . Corresponding SOX9 RNA-seq data are presented for the same tissues.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0034.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Western Blot: SOX9 Antibody [NBP1-85551] - Analysis in U-251MG cells transfected with control siRNA, target specific siRNA probe #1 and #2, using anti-SOX9 antibody. Remaining relative intensity is presented. Loading control: anti-GAPDH.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Western-Blot-NBP1-85551-img0035.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunocytochemistry/Immunofluorescence: SOX9 Antibody [NBP1-85551] - Further analysis of P2X7-EGFP expressing cells in the dentate gyrus and CA1 region. Co-staining of EGFP with the alternative astrocyte marker SOX9 in the CA1 region. Scale bar: 50 um. DAPI staining in blue (n = at least three animals in all experiments). Image collected and cropped by CiteAb from the following publication (//elifesciences.org/articles/36217), licensed under a CC-BY license.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-85551-img0037.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Western Blot: SOX9 Antibody [NBP1-85551] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Western-Blot-NBP1-85551-img0025.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunocytochemistry/Immunofluorescence: SOX9 Antibody [NBP1-85551] - Staining of human cell line U-251 MG shows localization to nucleoplasm. Antibody staining is shown in green.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-85551-img0036.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human colorectal cancer shows moderate to strong nuclear positivity in tumor cells.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0029.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human glioma shows moderate to strong nuclear positivity in tumor cells.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0030.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human skeletal muscle shows no nuclear positivity in striated muscle fibers as expected.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0031.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human small intestine shows moderate nuclear positivity in a subset of glandular cells.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0032.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human testis shows moderate nuclear positivity in a subset of cells in seminiferous ducts.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0033.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Simple Western: SOX9 Antibody [NBP1-85551] - Simple Western lane view shows a specific band for SOX9 in 0.1 mg/ml of U-251MG sp (left) and HepG2 (right) lysate. 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Scale bar represents 50\u00a0\u03bcm. Image collected & cropped by CiteAb from the following publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-244), licensed under a CC-BY license. 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Antibody concentration 10 ug/ml.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-3C10-Immunocytochemistry-Immunofluorescence-H00006662-M02-img0008.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry-Paraffin: SOX9 Antibody (3C10) [H00006662-M02] - Analysis of monoclonal antibody to SOX9 on formalin-fixed paraffin-embedded human tonsil. 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Image from verified customer review.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-3C10-Immunohistochemistry-Paraffin-H00006662-M02-img0006.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunoprecipitation: SOX9 Antibody (3C10) [H00006662-M02] - Analysis of SOX9 transfected lysate using anti-SOX9 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with SOX9 MaxPab rabbit polyclonal antibody.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-3C10-Immunoprecipitation-H00006662-M02-img0011.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"ELISA: SOX9 Antibody (3C10) [H00006662-M02] - Detection limit for recombinant GST tagged SOX9 is 0.1 ng/ml as a capture antibody.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-3C10-ELISA-H00006662-M02-img0015.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/sox9-antibody_nbp2-24659"],"name":["SOX9 Antibody"],"image":[[{"@type":"ImageObject","caption":"Simple Western: SOX9 Antibody [NBP2-24659] - Simple Western lane view shows a specific band for SOX9 in 0.5 mg/ml of Human Brain lysate. 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(C) Immunohistochemical staining of Sox9 in DMM-induced OA mice with administration of PBS and 3'-sialyllactose. Image collected and cropped by CiteAb from the following publication (//doi.wiley.com/10.1111/jcmm.13292), licensed under a CC-BY license.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-NBP2-24659-img0008.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunohistochemistry-Frozen: SOX9 Antibody [NBP2-24659] - Feline optic nerve tissue section was incubated with antibody at 1:200 and further stained with Alexa secondary antibody. Image was captured with an epifluorescence microscope. This image was submitted via customer review.","url":"https://images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Frozen-NBP2-24659-img0005.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Western Blot: SOX9 Antibody [NBP2-24659] - Analysis of SOX9 in mouse embryo brain lysate in the 1) absence and 2) presence of immunizing peptide using SOX9 antibody at 2 ug/ml. 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Not internally tested by Novus Biologicals.","url":"https://images.novusbio.com/fullsize/nbp2-24659_rabbit-polyclonal-sox9-antibody-310202416113513.jpg","width":400,"height":400}]]},{"@type":"Thing","url":["https://www.novusbio.com/products/braf35-antibody-1f6_h00010362-m01"],"name":["BRAF35 Antibody (1F6)"],"image":[[{"@type":"ImageObject","caption":"Western Blot: BRAF35 Antibody (1F6) [H00010362-M01] - HMG20B monoclonal antibody (M01), clone IF6 Analysis of HMG20B expression in HeLa.","url":"https://images.novusbio.com/fullsize/BRAF35-Antibody-1F6-Western-Blot-H00010362-M01-img0010.jpg","width":400,"height":400},{"@type":"ImageObject","caption":"Immunocytochemistry/Immunofluorescence: BRAF35 Antibody (1F6) [H00010362-M01] - Analysis of monoclonal antibody to HMG20B on HeLa cell. 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class="search_facet_name">SOX9<span class=facet_count> (6)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&common_name=SOX1" rel="nofollow"><span data-facet="SOX1 (2)" class="search_facet_name">SOX1<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_common_name" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&common_name=BRAF35" rel="nofollow"><span data-facet="BRAF35 (1)" class="search_facet_name">BRAF35<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_applications"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Applications</span></h4> <div class="facet_list"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Western%20Blot" rel="nofollow"><span data-facet="Western Blot (9)" class="search_facet_name">Western Blot<span class=facet_count> (9)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Immunocytochemistry/%20Immunofluorescence" rel="nofollow"><span data-facet="Immunocytochemistry/ Immunofluorescence (6)" class="search_facet_name">Immunocytochemistry / Immunofluorescence<span class=facet_count> (6)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Immunohistochemistry" rel="nofollow"><span data-facet="Immunohistochemistry (6)" class="search_facet_name">Immunohistochemistry<span class=facet_count> (6)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Simple%20Western" rel="nofollow"><span data-facet="Simple Western (4)" class="search_facet_name">Simple Western<span class=facet_count> (4)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Affinity%20Purification" rel="nofollow"><span data-facet="Affinity Purification (1)" class="search_facet_name">Affinity Purification<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=ELISA" rel="nofollow"><span data-facet="ELISA (3)" class="search_facet_name">ELISA<span class=facet_count> (3)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Functional%20Assay" rel="nofollow"><span data-facet="Functional Assay (1)" class="search_facet_name">Functional Assay<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Gel%20Shift" rel="nofollow"><span data-facet="Gel Shift (1)" class="search_facet_name">Gel Shift<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Immunocytochemistry/%20Immunofluorescence" rel="nofollow"><span data-facet="Immunocytochemistry / Immunofluorescence (6)" class="search_facet_name">Immunocytochemistry / Immunofluorescence<span class=facet_count> (6)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Immunohistochemistry" rel="nofollow"><span data-facet="Immunohistochemistry (6)" class="search_facet_name">Immunohistochemistry<span class=facet_count> (6)</span></span></a></li></ul><ul class="more_facets"><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Immunoprecipitation" rel="nofollow"><span data-facet="Immunoprecipitation (1)" class="search_facet_name">Immunoprecipitation<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Knockdown%20Validated" rel="nofollow"><span data-facet="Knockdown Validated (2)" class="search_facet_name">Knockdown Validated<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Microarray" rel="nofollow"><span data-facet="Microarray (1)" class="search_facet_name">Microarray<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=SDS-PAGE" rel="nofollow"><span data-facet="SDS-PAGE (1)" class="search_facet_name">SDS-PAGE<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Simple%20Western" rel="nofollow"><span data-facet="Simple Western (4)" class="search_facet_name">Simple Western<span class=facet_count> (4)</span></span></a></li><li><input type="checkbox" name="fc_applications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&applications=Western%20Blot" rel="nofollow"><span data-facet="Western Blot (9)" class="search_facet_name">Western Blot<span class=facet_count> (9)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_reactivity"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Reactivity</span></h4> <div class="facet_list"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Human" rel="nofollow"><span data-facet="Human (9)" class="search_facet_name">Human<span class=facet_count> (9)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Mouse" rel="nofollow"><span data-facet="Mouse (5)" class="search_facet_name">Mouse<span class=facet_count> (5)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Rat" rel="nofollow"><span data-facet="Rat (5)" class="search_facet_name">Rat<span class=facet_count> (5)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Canine" rel="nofollow"><span data-facet="Canine (3)" class="search_facet_name">Canine<span class=facet_count> (3)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Bovine" rel="nofollow"><span data-facet="Bovine (2)" class="search_facet_name">Bovine<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Canine" rel="nofollow"><span data-facet="Canine (3)" class="search_facet_name">Canine<span class=facet_count> (3)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Chimpanzee" rel="nofollow"><span data-facet="Chimpanzee (1)" class="search_facet_name">Chimpanzee<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Equine" rel="nofollow"><span data-facet="Equine (2)" class="search_facet_name">Equine<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Feline" rel="nofollow"><span data-facet="Feline (2)" class="search_facet_name">Feline<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Goat" rel="nofollow"><span data-facet="Goat (1)" class="search_facet_name">Goat<span class=facet_count> (1)</span></span></a></li></ul><ul class="more_facets"><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Human" rel="nofollow"><span data-facet="Human (9)" class="search_facet_name">Human<span class=facet_count> (9)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Monkey" rel="nofollow"><span data-facet="Monkey (1)" class="search_facet_name">Monkey<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Mouse" rel="nofollow"><span data-facet="Mouse (5)" class="search_facet_name">Mouse<span class=facet_count> (5)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Opossum" rel="nofollow"><span data-facet="Opossum (2)" class="search_facet_name">Opossum<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Porcine" rel="nofollow"><span data-facet="Porcine (1)" class="search_facet_name">Porcine<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Primate" rel="nofollow"><span data-facet="Primate (2)" class="search_facet_name">Primate<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Rat" rel="nofollow"><span data-facet="Rat (5)" class="search_facet_name">Rat<span class=facet_count> (5)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Sheep" rel="nofollow"><span data-facet="Sheep (1)" class="search_facet_name">Sheep<span class=facet_count> (1)</span></span></a></li><li><input type="checkbox" name="fc_species" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&species=Xenopus" rel="nofollow"><span data-facet="Xenopus (1)" class="search_facet_name">Xenopus<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1" class="search_clear_link">clear</a><div class="facet_container_citation"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Citation</span></h4> <div class="facet_list"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_count_publications" class="facet_input" checked="checked"><a href="/search?keywords=SOX1" rel="nofollow"><span data-facet="1 or more (9)" class="search_facet_name">1 or more (9)</span></a></li><li><input type="radio" name="fc_count_publications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=10" rel="nofollow"><span data-facet="10 or more (4)" class="search_facet_name">10 or more (4)</span></a></li><li><input type="radio" name="fc_count_publications" class="facet_input"><a href="/search?keywords=SOX1&count_publications=100" rel="nofollow"><span data-facet="100 or more (2)" class="search_facet_name">100 or more (2)</span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_antibody-validation"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Antibody Validation</span></h4> <div class="facet_list"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="checkbox" name="fc_image_badge_data" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&image_badge_data=Genetic%20Strategies" rel="nofollow"><span data-facet="Genetic Strategies (2)" class="search_facet_name">Genetic Strategies<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_image_badge_data" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&image_badge_data=Orthogonal%20Strategies" rel="nofollow"><span data-facet="Orthogonal Strategies (2)" class="search_facet_name">Orthogonal Strategies<span class=facet_count> (2)</span></span></a></li><li><input type="checkbox" name="fc_image_badge_data" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&image_badge_data=Biological%20Strategies" rel="nofollow"><span data-facet="Biological Strategies (1)" class="search_facet_name">Biological Strategies<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_reviews"><h4><span class="facet_logo facet_logo_open"></span> <span class="facet_name">Reviews</span></h4> <div class="facet_list"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_stars_novus" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&stars_novus=5.0" rel="nofollow"><span data-facet=" 5 (4)" class="search_facet_name"><span class="searchImage_star5"></span> 5 (4)</span></a></li><li><input type="radio" name="fc_stars_novus" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&stars_novus=3.0" rel="nofollow"><span data-facet=" 3 & Up (5)" class="search_facet_name"><span class="searchImage_star3"></span> 3 & Up (5)</span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_host"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Host</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_host" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&host=Mouse" rel="nofollow"><span data-facet="Mouse (3)" class="search_facet_name">Mouse<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&host=Rabbit" rel="nofollow"><span data-facet="Rabbit (3)" class="search_facet_name">Rabbit<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_host" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&host=Goat" rel="nofollow"><span data-facet="Goat (2)" class="search_facet_name">Goat<span class=facet_count> (2)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_available-conjugates"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Available Conjugates</span></h4> <div class="facet_list compacted"><input type="text" class="facet_category_search" value="Search"> <div class="search_icon"></div><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Unconjugated" rel="nofollow"><span data-facet="Unconjugated (9)" class="search_facet_name">Unconjugated<span class=facet_count> (9)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Biotin" rel="nofollow"><span data-facet="Biotin (3)" class="search_facet_name">Biotin<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Alexa%20Fluor%20350" rel="nofollow"><span data-facet="Alexa Fluor 350 (2)" class="search_facet_name">Alexa Fluor 350<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Alexa%20Fluor%20405" rel="nofollow"><span data-facet="Alexa Fluor 405 (2)" class="search_facet_name">Alexa Fluor 405<span class=facet_count> (2)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Alexa%20Fluor%20350" rel="nofollow"><span data-facet="Alexa Fluor 350 (2)" class="search_facet_name">Alexa Fluor 350<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Alexa%20Fluor%20405" rel="nofollow"><span data-facet="Alexa Fluor 405 (2)" class="search_facet_name">Alexa Fluor 405<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Alexa%20Fluor%20488" rel="nofollow"><span data-facet="Alexa Fluor 488 (2)" class="search_facet_name">Alexa Fluor 488<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Alexa%20Fluor%20532" rel="nofollow"><span data-facet="Alexa Fluor 532 (2)" class="search_facet_name">Alexa Fluor 532<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Alexa%20Fluor%20594" rel="nofollow"><span data-facet="Alexa Fluor 594 (2)" class="search_facet_name">Alexa Fluor 594<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Alexa%20Fluor%20647" rel="nofollow"><span data-facet="Alexa Fluor 647 (2)" class="search_facet_name">Alexa Fluor 647<span class=facet_count> (2)</span></span></a></li></ul><ul class="more_facets"><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Alexa%20Fluor%20700" rel="nofollow"><span data-facet="Alexa Fluor 700 (2)" class="search_facet_name">Alexa Fluor 700<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Alexa%20Fluor%20750" rel="nofollow"><span data-facet="Alexa Fluor 750 (2)" class="search_facet_name">Alexa Fluor 750<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Allophycocyanin" rel="nofollow"><span data-facet="Allophycocyanin (2)" class="search_facet_name">Allophycocyanin<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Biotin" rel="nofollow"><span data-facet="Biotin (3)" class="search_facet_name">Biotin<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=CoraFluor%201" rel="nofollow"><span data-facet="CoraFluor 1 (2)" class="search_facet_name">CoraFluor 1<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=DyLight%20350" rel="nofollow"><span data-facet="DyLight 350 (2)" class="search_facet_name">DyLight 350<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=DyLight%20405" rel="nofollow"><span data-facet="DyLight 405 (2)" class="search_facet_name">DyLight 405<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=DyLight%20488" rel="nofollow"><span data-facet="DyLight 488 (2)" class="search_facet_name">DyLight 488<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=DyLight%20550" rel="nofollow"><span data-facet="DyLight 550 (2)" class="search_facet_name">DyLight 550<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=DyLight%20594" rel="nofollow"><span data-facet="DyLight 594 (2)" class="search_facet_name">DyLight 594<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=DyLight%20650" rel="nofollow"><span data-facet="DyLight 650 (2)" class="search_facet_name">DyLight 650<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=DyLight%20680" rel="nofollow"><span data-facet="DyLight 680 (2)" class="search_facet_name">DyLight 680<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=DyLight%20755" rel="nofollow"><span data-facet="DyLight 755 (2)" class="search_facet_name">DyLight 755<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=FITC" rel="nofollow"><span data-facet="FITC (1)" class="search_facet_name">FITC<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=HRP" rel="nofollow"><span data-facet="HRP (2)" class="search_facet_name">HRP<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Janelia%20Fluor%20525" rel="nofollow"><span data-facet="Janelia Fluor 525 (2)" class="search_facet_name">Janelia Fluor 525<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Janelia%20Fluor%20549" rel="nofollow"><span data-facet="Janelia Fluor 549 (2)" class="search_facet_name">Janelia Fluor 549<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Janelia%20Fluor%20646" rel="nofollow"><span data-facet="Janelia Fluor 646 (2)" class="search_facet_name">Janelia Fluor 646<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Janelia%20Fluor%20669" rel="nofollow"><span data-facet="Janelia Fluor 669 (2)" class="search_facet_name">Janelia Fluor 669<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=NL557" rel="nofollow"><span data-facet="NL557 (1)" class="search_facet_name">NL557<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=PE" rel="nofollow"><span data-facet="PE (2)" class="search_facet_name">PE<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=PerCP" rel="nofollow"><span data-facet="PerCP (2)" class="search_facet_name">PerCP<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=Unconjugated" rel="nofollow"><span data-facet="Unconjugated (9)" class="search_facet_name">Unconjugated<span class=facet_count> (9)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=mFluor%20Violet%20450%20SE" rel="nofollow"><span data-facet="mFluor Violet 450 SE (2)" class="search_facet_name">mFluor Violet 450 SE<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=mFluor%20Violet%20500%20SE" rel="nofollow"><span data-facet="mFluor Violet 500 SE (2)" class="search_facet_name">mFluor Violet 500 SE<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_facet_conjugate" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&facet_conjugate=mFluor%20Violet%20610%20SE" rel="nofollow"><span data-facet="mFluor Violet 610 SE (2)" class="search_facet_name">mFluor Violet 610 SE<span class=facet_count> (2)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_marker"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Marker</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_marker" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&marker=Sertoli%20Cell%20Marker" rel="nofollow"><span data-facet="Sertoli Cell Marker (3)" class="search_facet_name">Sertoli Cell Marker<span class=facet_count> (3)</span></span></a></li><li><input type="radio" name="fc_marker" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&marker=Ectoderm%20Marker" rel="nofollow"><span data-facet="Ectoderm Marker (1)" class="search_facet_name">Ectoderm Marker<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_modification"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Modification</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_modification" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&modification=No%20Modification" rel="nofollow"><span data-facet="No Modification (9)" class="search_facet_name">No Modification <span class=facet_count> (9)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_clonality"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Clonality</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_clonality" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&clonality=Polyclonal" rel="nofollow"><span data-facet="Polyclonal (5)" class="search_facet_name">Polyclonal<span class=facet_count> (5)</span></span></a></li><li><input type="radio" name="fc_clonality" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&clonality=Monoclonal" rel="nofollow"><span data-facet="Monoclonal (3)" class="search_facet_name">Monoclonal<span class=facet_count> (3)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_clone"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Clone</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_clone" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&clone=1F6" rel="nofollow"><span data-facet="1F6 (1)" class="search_facet_name">1F6<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&clone=3C10" rel="nofollow"><span data-facet="3C10 (1)" class="search_facet_name">3C10<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_clone" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&clone=CL0639" rel="nofollow"><span data-facet="CL0639 (1)" class="search_facet_name">CL0639<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_gene-symbol"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Gene Symbol</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&gene_symbol=SOX9" rel="nofollow"><span data-facet="SOX9 (6)" class="search_facet_name">SOX9<span class=facet_count> (6)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&gene_symbol=SOX1" rel="nofollow"><span data-facet="SOX1 (2)" class="search_facet_name">SOX1<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_gene_symbol" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&gene_symbol=HMG20B" rel="nofollow"><span data-facet="HMG20B (1)" class="search_facet_name">HMG20B<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_images-type"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Images Type</span></h4> <div class="facet_list compacted"><div class="search_top_category_facets search_category_facets"><ul><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Western%20Blot" rel="nofollow"><span data-facet="Western Blot (8)" class="search_facet_name">Western Blot<span class=facet_count> (8)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Immunocytochemistry/%20Immunofluorescence" rel="nofollow"><span data-facet="Immunocytochemistry/ Immunofluorescence (6)" class="search_facet_name">Immunocytochemistry / Immunofluorescence<span class=facet_count> (6)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Immunohistochemistry" rel="nofollow"><span data-facet="Immunohistochemistry (5)" class="search_facet_name">Immunohistochemistry<span class=facet_count> (5)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Immunohistochemistry-Paraffin" rel="nofollow"><span data-facet="Immunohistochemistry-Paraffin (5)" class="search_facet_name">Immunohistochemistry-Paraffin<span class=facet_count> (5)</span></span></a></li><li class="a-z">-------------- All A - Z ---------------</li></ul></div> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=ELISA" rel="nofollow"><span data-facet="ELISA (1)" class="search_facet_name">ELISA<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Immunocytochemistry" rel="nofollow"><span data-facet="Immunocytochemistry (2)" class="search_facet_name">Immunocytochemistry<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Immunocytochemistry/%20Immunofluorescence" rel="nofollow"><span data-facet="Immunocytochemistry / Immunofluorescence (6)" class="search_facet_name">Immunocytochemistry / Immunofluorescence<span class=facet_count> (6)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Immunohistochemistry" rel="nofollow"><span data-facet="Immunohistochemistry (5)" class="search_facet_name">Immunohistochemistry<span class=facet_count> (5)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Immunohistochemistry-Frozen" rel="nofollow"><span data-facet="Immunohistochemistry-Frozen (1)" class="search_facet_name">Immunohistochemistry-Frozen<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Immunohistochemistry-Paraffin" rel="nofollow"><span data-facet="Immunohistochemistry-Paraffin (5)" class="search_facet_name">Immunohistochemistry-Paraffin<span class=facet_count> (5)</span></span></a></li></ul><ul class="more_facets"><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Immunoprecipitation" rel="nofollow"><span data-facet="Immunoprecipitation (1)" class="search_facet_name">Immunoprecipitation<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=SDS-PAGE" rel="nofollow"><span data-facet="SDS-PAGE (1)" class="search_facet_name">SDS-PAGE<span class=facet_count> (1)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Simple%20Western" rel="nofollow"><span data-facet="Simple Western (4)" class="search_facet_name">Simple Western<span class=facet_count> (4)</span></span></a></li><li><input type="radio" name="fc_images_type" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&images_type=Western%20Blot" rel="nofollow"><span data-facet="Western Blot (8)" class="search_facet_name">Western Blot<span class=facet_count> (8)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_isotype"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Isotype</span></h4> <div class="facet_list compacted"> <div class="search_all_category_facets search_category_facets"> <ul><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&isotype=IgG" rel="nofollow"><span data-facet="IgG (5)" class="search_facet_name">IgG<span class=facet_count> (5)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&isotype=IgG2a%20Kappa" rel="nofollow"><span data-facet="IgG2a Kappa (2)" class="search_facet_name">IgG2a Kappa<span class=facet_count> (2)</span></span></a></li><li><input type="radio" name="fc_isotype" class="facet_input"><a href="/search?keywords=SOX1&count_publications=1&isotype=IgG2a" rel="nofollow"><span data-facet="IgG2a (1)" class="search_facet_name">IgG2a<span class=facet_count> (1)</span></span></a></li> </ul> </div> </div> </div><a href="/search?keywords=SOX1&count_publications=1" class="search_clear_link">clear</a><div class="facet_container_preservative"><h4><span class="facet_logo facet_logo_closed"></span> <span class="facet_name">Preservative</span></h4> <div class="facet_list 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PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for SOX1 at approximately 39 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox"> <img src="//images.novusbio.com/images2/SOX1_AF3369_Western_Blot_21133.jpg" title="Western blot shows lysates of undifferentiated iBJ6 human iPS cells and iBJ6 human iPS cells differentiated into neuroprogenitor cells. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for SOX1 at approximately 39 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." alt="Western blot shows lysates of undifferentiated iBJ6 human iPS cells and iBJ6 human iPS cells differentiated into neuroprogenitor cells. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for SOX1 at approximately 39 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize2/SOX1_AF3369_Immunocytochemistry_13805.jpg" title="SOX1 was detected in immersion fixed BG01V human embryonic stem cells differentiated into neural progenitor cells using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Nestin was also detected using Mouse Anti-Mouse/Rat Nestin Monoclonal Antibody (MAB2736) and stained using the NorthernLights™ 493-conjugated Anti-Mouse IgG Secondary Antibody (green; Catalog # NL009). Specific staining of SOX1 was localized to nuclei. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips." class="big_lightbox"> <img src="//images.novusbio.com/images2/SOX1_AF3369_Immunocytochemistry_13805.jpg" alt="SOX1 was detected in immersion fixed BG01V human embryonic stem cells differentiated into neural progenitor cells using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Nestin was also detected using Mouse Anti-Mouse/Rat Nestin Monoclonal Antibody (MAB2736) and stained using the NorthernLights™ 493-conjugated Anti-Mouse IgG Secondary Antibody (green; Catalog # NL009). Specific staining of SOX1 was localized to nuclei. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize2/SOX1_AF3369_Immunocytochemistry_9786.jpg" title="SOX1 was detected in immersion fixed NTera-2 human testicular embryonic carcinoma cell line differentiated with retinoic acid using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 493-conjugated Anti-Goat IgG Secondary Antibody (green, upper panel; NL003) and counterstained with DAPI (blue, lower panel). View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_lightbox"> <img src="//images.novusbio.com/images2/SOX1_AF3369_Immunocytochemistry_9786.jpg" alt="SOX1 was detected in immersion fixed NTera-2 human testicular embryonic carcinoma cell line differentiated with retinoic acid using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 493-conjugated Anti-Goat IgG Secondary Antibody (green, upper panel; NL003) and counterstained with DAPI (blue, lower panel). View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize2/SOX1_AF3369_Immunocytochemistry_12364.jpg" title="SOX1 was detected in immersion fixed rat cortical stem cells (NSC001) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_lightbox"> <img src="//images.novusbio.com/images2/SOX1_AF3369_Immunocytochemistry_12364.jpg" alt="SOX1 was detected in immersion fixed rat cortical stem cells (NSC001) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize2/SOX1_AF3369_Immunocytochemistry_12365.jpg" title="SOX1 was detected in immersion fixed mouse cortical stem cells (Catalog # NSC002) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_lightbox"> <img src="//images.novusbio.com/images2/SOX1_AF3369_Immunocytochemistry_12365.jpg" alt="SOX1 was detected in immersion fixed mouse cortical stem cells (Catalog # NSC002) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize2/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-immunohistochemistry-19202111112.jpg" title="SOX1 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei in neuron. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." class="big_lightbox"> <img src="//images.novusbio.com/images2/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-immunohistochemistry-19202111112.jpg" alt="SOX1 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei in neuron. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize2/SOX1_AF3369_Simple_Western_21134.jpg" title=" Simple Western lane view shows lysates of undifferentiated iBJ6 human iPS cells andiBJ6 human iPS cells differentiated into neuroprogenitor cells, loaded at 0.2 mg/mL. A specific band was detected for SOX1 at approximately 50 kDa (as indicated) using 10 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system. " class="big_lightbox"> <img src="//images.novusbio.com/images2/SOX1_AF3369_Simple_Western_21134.jpg" alt=" Simple Western lane view shows lysates of undifferentiated iBJ6 human iPS cells andiBJ6 human iPS cells differentiated into neuroprogenitor cells, loaded at 0.2 mg/mL. A specific band was detected for SOX1 at approximately 50 kDa (as indicated) using 10 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system. " class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-4120241048547.jpg" title="Characterization of NSCs and cortical neurons derived from FKRP‐ and CRISPR/Cas9 corrected‐iPSCsA, BRepresentative images of NSCs derived from FKRP‐ and corrected‐iPSC lines expressing SOX1, SOX2, and nestin.C, DQuantification of percentage of SOX1+ (C) and SOX2+ (D) cells in culture. The efficiency of neural induction is more than 99% in FKRP‐ and corrected‐iPSC (5D17, 5D23, and 3B17) lines. Data are mean ± s.d. n = 4 technical replicates.E, FFKRP‐ and corrected‐NSC lines can be further differentiated to cortical neural progenitor cells, expressing PAX6, OTX2, and vimentin.G–IQuantification of percentage of PAX6+ (G) and OTX2+ (H) cells in culture. About 91‐98% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express PAX6 (G). About 93‐96% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express OTX2 (H). Of the OTX2+ population, about 60‐67% cells are also Ki67+ cycling progenitors (I). Data are mean ± s.d. n = 4 technical replicates.J, KGlutamatergic projection neurons derived from FKRP and corrected (5D17, 5D23, and 3B17) progenitor cells. The vast majority of neurons contain vGlut1+ punctae in their neurites (labeled by Tuj1). Right panels are enlarged images from the insets of left panels.Data information: Scale bars, 50 μm. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31566294), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-4120241048547.jpg" alt="Characterization of NSCs and cortical neurons derived from FKRP‐ and CRISPR/Cas9 corrected‐iPSCsA, BRepresentative images of NSCs derived from FKRP‐ and corrected‐iPSC lines expressing SOX1, SOX2, and nestin.C, DQuantification of percentage of SOX1+ (C) and SOX2+ (D) cells in culture. The efficiency of neural induction is more than 99% in FKRP‐ and corrected‐iPSC (5D17, 5D23, and 3B17) lines. Data are mean ± s.d. n = 4 technical replicates.E, FFKRP‐ and corrected‐NSC lines can be further differentiated to cortical neural progenitor cells, expressing PAX6, OTX2, and vimentin.G–IQuantification of percentage of PAX6+ (G) and OTX2+ (H) cells in culture. About 91‐98% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express PAX6 (G). About 93‐96% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express OTX2 (H). Of the OTX2+ population, about 60‐67% cells are also Ki67+ cycling progenitors (I). Data are mean ± s.d. n = 4 technical replicates.J, KGlutamatergic projection neurons derived from FKRP and corrected (5D17, 5D23, and 3B17) progenitor cells. The vast majority of neurons contain vGlut1+ punctae in their neurites (labeled by Tuj1). Right panels are enlarged images from the insets of left panels.Data information: Scale bars, 50 μm. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31566294), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-41202410485410.jpg" title="Characterization of NSCs and cortical neurons derived from FKRP‐ and CRISPR/Cas9 corrected‐iPSCsA, BRepresentative images of NSCs derived from FKRP‐ and corrected‐iPSC lines expressing SOX1, SOX2, and nestin.C, DQuantification of percentage of SOX1+ (C) and SOX2+ (D) cells in culture. The efficiency of neural induction is more than 99% in FKRP‐ and corrected‐iPSC (5D17, 5D23, and 3B17) lines. Data are mean ± s.d. n = 4 technical replicates.E, FFKRP‐ and corrected‐NSC lines can be further differentiated to cortical neural progenitor cells, expressing PAX6, OTX2, and vimentin.G–IQuantification of percentage of PAX6+ (G) and OTX2+ (H) cells in culture. About 91‐98% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express PAX6 (G). About 93‐96% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express OTX2 (H). Of the OTX2+ population, about 60‐67% cells are also Ki67+ cycling progenitors (I). Data are mean ± s.d. n = 4 technical replicates.J, KGlutamatergic projection neurons derived from FKRP and corrected (5D17, 5D23, and 3B17) progenitor cells. The vast majority of neurons contain vGlut1+ punctae in their neurites (labeled by Tuj1). Right panels are enlarged images from the insets of left panels.Data information: Scale bars, 50 μm. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31566294), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-41202410485410.jpg" alt="Characterization of NSCs and cortical neurons derived from FKRP‐ and CRISPR/Cas9 corrected‐iPSCsA, BRepresentative images of NSCs derived from FKRP‐ and corrected‐iPSC lines expressing SOX1, SOX2, and nestin.C, DQuantification of percentage of SOX1+ (C) and SOX2+ (D) cells in culture. The efficiency of neural induction is more than 99% in FKRP‐ and corrected‐iPSC (5D17, 5D23, and 3B17) lines. Data are mean ± s.d. n = 4 technical replicates.E, FFKRP‐ and corrected‐NSC lines can be further differentiated to cortical neural progenitor cells, expressing PAX6, OTX2, and vimentin.G–IQuantification of percentage of PAX6+ (G) and OTX2+ (H) cells in culture. About 91‐98% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express PAX6 (G). About 93‐96% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express OTX2 (H). Of the OTX2+ population, about 60‐67% cells are also Ki67+ cycling progenitors (I). Data are mean ± s.d. n = 4 technical replicates.J, KGlutamatergic projection neurons derived from FKRP and corrected (5D17, 5D23, and 3B17) progenitor cells. The vast majority of neurons contain vGlut1+ punctae in their neurites (labeled by Tuj1). Right panels are enlarged images from the insets of left panels.Data information: Scale bars, 50 μm. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31566294), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-4120241048241.jpg" title="Expression of NSUN2 in the Human Developing Brain and NES Cells(A) DAPI-stained human embryo (6 weeks of gestation) marked for prosencephalon, mesencephalon, and rhombencephalon. Region in square is magnified in (B). Scale bar, 1 mm.(B) Prosencephalon labeled for NSUN2 and SOX1. Region in squares are magnified in (b′) and (b″). Arrows indicate NSUN2-positive cells. Scale bar, 100 μm.(C–F) Bright-field image (C) and immunofluorescence (D–F) of AF22 (upper panels) and Sai1 (lower panels) cells labeled for Nestin (D), SOX2 (E), and beta III-tubulin (F). Scale bar, 50 μm.(G and H) NES cells co-labeled for NSUN2 and Nestin (NES) (G) or SOX1 (H).(I) Differentiation protocol.(J–L) Differentiated AF22 and Sai1 cells (day 15) labeled for Nestin (NES; J), SOX2 (K), and beta III-tubulin (L). Scale bars: 50 μm.(M) Western blot for NSUN2, beta III-tubulin (TUBB3), GFAP, SOX2, and Nestin during differentiation (days). alpha -Tubulin served as loading control.Nuclei are counterstained with DAPI (A, B, D–F, J–L). Image collected and cropped by CiteAb from the following publication (//linkinghub.elsevier.com/retrieve/pii/S2213671116302764), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-4120241048241.jpg" alt="Expression of NSUN2 in the Human Developing Brain and NES Cells(A) DAPI-stained human embryo (6 weeks of gestation) marked for prosencephalon, mesencephalon, and rhombencephalon. Region in square is magnified in (B). Scale bar, 1 mm.(B) Prosencephalon labeled for NSUN2 and SOX1. Region in squares are magnified in (b′) and (b″). Arrows indicate NSUN2-positive cells. Scale bar, 100 μm.(C–F) Bright-field image (C) and immunofluorescence (D–F) of AF22 (upper panels) and Sai1 (lower panels) cells labeled for Nestin (D), SOX2 (E), and beta III-tubulin (F). Scale bar, 50 μm.(G and H) NES cells co-labeled for NSUN2 and Nestin (NES) (G) or SOX1 (H).(I) Differentiation protocol.(J–L) Differentiated AF22 and Sai1 cells (day 15) labeled for Nestin (NES; J), SOX2 (K), and beta III-tubulin (L). Scale bars: 50 μm.(M) Western blot for NSUN2, beta III-tubulin (TUBB3), GFAP, SOX2, and Nestin during differentiation (days). alpha -Tubulin served as loading control.Nuclei are counterstained with DAPI (A, B, D–F, J–L). Image collected and cropped by CiteAb from the following publication (//linkinghub.elsevier.com/retrieve/pii/S2213671116302764), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-41202410482417.jpg" title="Expression of NSUN2 in the Human Developing Brain and NES Cells(A) DAPI-stained human embryo (6 weeks of gestation) marked for prosencephalon, mesencephalon, and rhombencephalon. Region in square is magnified in (B). Scale bar, 1 mm.(B) Prosencephalon labeled for NSUN2 and SOX1. Region in squares are magnified in (b′) and (b″). Arrows indicate NSUN2-positive cells. Scale bar, 100 μm.(C–F) Bright-field image (C) and immunofluorescence (D–F) of AF22 (upper panels) and Sai1 (lower panels) cells labeled for Nestin (D), SOX2 (E), and beta III-tubulin (F). Scale bar, 50 μm.(G and H) NES cells co-labeled for NSUN2 and Nestin (NES) (G) or SOX1 (H).(I) Differentiation protocol.(J–L) Differentiated AF22 and Sai1 cells (day 15) labeled for Nestin (NES; J), SOX2 (K), and beta III-tubulin (L). Scale bars: 50 μm.(M) Western blot for NSUN2, beta III-tubulin (TUBB3), GFAP, SOX2, and Nestin during differentiation (days). alpha -Tubulin served as loading control.Nuclei are counterstained with DAPI (A, B, D–F, J–L). Image collected and cropped by CiteAb from the following publication (//linkinghub.elsevier.com/retrieve/pii/S2213671116302764), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-41202410482417.jpg" alt="Expression of NSUN2 in the Human Developing Brain and NES Cells(A) DAPI-stained human embryo (6 weeks of gestation) marked for prosencephalon, mesencephalon, and rhombencephalon. Region in square is magnified in (B). Scale bar, 1 mm.(B) Prosencephalon labeled for NSUN2 and SOX1. Region in squares are magnified in (b′) and (b″). Arrows indicate NSUN2-positive cells. Scale bar, 100 μm.(C–F) Bright-field image (C) and immunofluorescence (D–F) of AF22 (upper panels) and Sai1 (lower panels) cells labeled for Nestin (D), SOX2 (E), and beta III-tubulin (F). Scale bar, 50 μm.(G and H) NES cells co-labeled for NSUN2 and Nestin (NES) (G) or SOX1 (H).(I) Differentiation protocol.(J–L) Differentiated AF22 and Sai1 cells (day 15) labeled for Nestin (NES; J), SOX2 (K), and beta III-tubulin (L). Scale bars: 50 μm.(M) Western blot for NSUN2, beta III-tubulin (TUBB3), GFAP, SOX2, and Nestin during differentiation (days). alpha -Tubulin served as loading control.Nuclei are counterstained with DAPI (A, B, D–F, J–L). Image collected and cropped by CiteAb from the following publication (//linkinghub.elsevier.com/retrieve/pii/S2213671116302764), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-41202410485430.jpg" title="GPI anchored proteins are required for neural differentiation.(A). Representative example of images of hiPSC-derived EBs and EB-derived rosettes during neural differentiation. Neural induction and rosette formation upon neural induction was assessed in three cell lines using a serum-free EB generation method. On day 2 (left) of hiPSC-derived EBs from PIGAwt, PIGAc.1234C>T, and PIGAnull after forced aggregation (20X magnification, scale bar is 50μm). On day 4 (middle), single homogeneous hiPSC-EBs collected were pooled in a 10 cm plate (4X magnification, scale bar is 100μm). On day 11 (right), neuroepithelial cells appeared and neural tube-like rosettes formed (EB-derived rosettes) and scale bar is 50μm. (B). Neural induction rates from EB-derived rosettes. The percentage of EB derived rosettes was 88.8% ± 4.6, 75.5% ± 9.8 and 68.4% ± 6.9 for PIGAwt, PIGAc.1234C>T, and PIGAnull, respectively. PIGAwt versus PIGAc.1234C>T (p>0.05, NS) and PIGAwt versus PIGAnull (*pT compared to PIGAwt. (F). Graphs depict the percentage of positive cells for SOX-1 (left) and Pax6 (right) in hNPCs derived from PIGAwt, PIGAc.1234C>T, and PIGAnull hiPSC lines. The hNPCs derived from the PIGAnull hiPSCs showed significantly decreased expression of SOX1 and PAX6. Similar levels of SOX1 and PAX6 were expressed in hNPCs from PIGAwt and PIGAc.1234C>T. All values represent mean ± SD. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0174074), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3369_human-mouse-rat-sox1-affinity-purified-polyclonal-ab-41202410485430.jpg" alt="GPI anchored proteins are required for neural differentiation.(A). Representative example of images of hiPSC-derived EBs and EB-derived rosettes during neural differentiation. Neural induction and rosette formation upon neural induction was assessed in three cell lines using a serum-free EB generation method. On day 2 (left) of hiPSC-derived EBs from PIGAwt, PIGAc.1234C>T, and PIGAnull after forced aggregation (20X magnification, scale bar is 50μm). On day 4 (middle), single homogeneous hiPSC-EBs collected were pooled in a 10 cm plate (4X magnification, scale bar is 100μm). On day 11 (right), neuroepithelial cells appeared and neural tube-like rosettes formed (EB-derived rosettes) and scale bar is 50μm. (B). Neural induction rates from EB-derived rosettes. The percentage of EB derived rosettes was 88.8% ± 4.6, 75.5% ± 9.8 and 68.4% ± 6.9 for PIGAwt, PIGAc.1234C>T, and PIGAnull, respectively. PIGAwt versus PIGAc.1234C>T (p>0.05, NS) and PIGAwt versus PIGAnull (*pT compared to PIGAwt. (F). Graphs depict the percentage of positive cells for SOX-1 (left) and Pax6 (right) in hNPCs derived from PIGAwt, PIGAc.1234C>T, and PIGAnull hiPSC lines. The hNPCs derived from the PIGAnull hiPSCs showed significantly decreased expression of SOX1 and PAX6. Similar levels of SOX1 and PAX6 were expressed in hNPCs from PIGAwt and PIGAc.1234C>T. All values represent mean ± SD. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0174074), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div></div><div id="ss_next0" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-0" class="cycle-circle-pager"></div><div id="image-caption-AF3369"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Simple Western">Simple Western</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Simple Western">Simple Western</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span></div><div class="field not3column"><label>Host:</label><div class="value">Goat Polyclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Goat Polyclonal</div><div class="field not3column"><label>Sizes:</label><div class="value">Sample Size Available</div></div><div class="forcol3 bottom_margin"><strong>Sizes:</strong> Sample Size Available</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  </div></div> </div><div class="product-attributes" style="margin-top:-10px;padding-top:0px;"><div class="field not3column"><label>&nbsp</label><div class="value"><div class="list_expand not3column options_closed" data-name="Formulations" data-wrapper-type=".formulations_wrapper" style="margin-left:0px;">Available Formulations <div class="expander option_closed"></div></div></div></div></div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="formulations">Formulations</button></div><div class="formulations_wrapper" data-title="SOX1 Antibody [Unconjugated]" data-catnum="AF3369"><table class="scf_table"> <thead> <tr> <th>Formulation</th> <th>Catalog #</th> <th>Availability</th> <th>Price</th> <th> </th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="AF3369-SP"> <td><a href="/products/sox1-antibody_af3369">Carrier Free</a></td> <td><a href="/products/sox1-antibody_af3369">AF3369-SP</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/429691"><div class="purchase_cart"></div></a></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["AF3369-SP"]' data-rendered="false"></div></div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"AF3369","Product Name":"Human\/Mouse\/Rat SOX1 Antibody","Description":"","Reactivity":"Human, Mouse, Rat","Applications":"WB, Simple Western, IHC, ICC\/IF","Source":"","Purification":"","Immunogen":"E. coli-derived recombinant human SOX1Asn242-Gly379 (Leu276Ile)Accession # NP_005977","Citations":"140","Purity":"","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/sox1-antibody_af3369\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/sox1-antibody_nbp2-24486">NBP2-24486</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-24486" data-name="SOX1 Antibody" data-position="2" class="ecommerce_link" href="/products/sox1-antibody_nbp2-24486" title="SOX1 Antibody" ><span> SOX1 Antibody</span></a><div class="ibubble not3column" title="</span><b>Purity:</b> Immunogen affinity purified<br/><b>Immunogen:</b> A portion of amino acids 100-150 of human SOX1 was used as the immunogen.<br/><b>Other Names:</b> SRY (sex determining region Y)-box 1, SRY-related HMG-box gene 1, transcription factor SOX-1<br/>"></div></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/sox1-antibody_nbp2-24486#ReviewsSection"><span class="stars5"></span> (1 Review)</a> </div> <div class="segment"> <a title="1 Publication specific to this product" href="/products/sox1-antibody_nbp2-24486#PublicationSection"><span class="publications"></span> (1 Publication)</a> </div> <div class="segment" style="float:right;"> <strong>0.1 mg</strong><span class="product_price" data-sku="NBP2-24486"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/sox1-antibody_nbp2-24486">NBP2-24486</a> </div><div id="ss_prev1" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-1" data-cycle-prev="#ss_prev1" data-cycle-next="#ss_next1" data-cycle-caption="#image-caption-NBP2-24486" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/SOX1-Antibody-Western-Blot-NBP2-24486-img0005.jpg" title="Western Blot: SOX1 Antibody [NBP2-24486] - Analysis of extracts from mouse brain using SOX1 antibody (NBP2-24486, 1:100). Image from verified customer review." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX1-Antibody-Western-Blot-NBP2-24486-img0005.jpg" title="Western Blot: SOX1 Antibody [NBP2-24486] - Analysis of extracts from mouse brain using SOX1 antibody (NBP2-24486, 1:100). Image from verified customer review." alt="Western Blot: SOX1 Antibody [NBP2-24486] - Analysis of extracts from mouse brain using SOX1 antibody (NBP2-24486, 1:100). Image from verified customer review." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX1-Antibody-Western-Blot-NBP2-24486-img0003.jpg" title="Western Blot: SOX1 Antibody [NBP2-24486] - Analysis of SOX1 in human brain lysate in the 1) absence and 2) presence of immunizing peptide. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX1-Antibody-Western-Blot-NBP2-24486-img0003.jpg" alt="Western Blot: SOX1 Antibody [NBP2-24486] - Analysis of SOX1 in human brain lysate in the 1) absence and 2) presence of immunizing peptide. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX1-Antibody-Western-Blot-NBP2-24486-img0004.jpg" title="Western Blot: SOX1 Antibody [NBP2-24486] - Analysis in D3 cell lysate in the 1) absence and 2) presence of immunizing peptide using NBP2-24486 at 1 ug/mL. Goat anti-rabbit Ig HRP secondary antibody (Novus, 20301) and PicoTect ECL substrate solution (Novus, 10087K) were used." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX1-Antibody-Western-Blot-NBP2-24486-img0004.jpg" alt="Western Blot: SOX1 Antibody [NBP2-24486] - Analysis in D3 cell lysate in the 1) absence and 2) presence of immunizing peptide using NBP2-24486 at 1 ug/mL. Goat anti-rabbit Ig HRP secondary antibody (Novus, 20301) and PicoTect ECL substrate solution (Novus, 10087K) were used." class="big_thumb" /> </a> </div></div><div id="ss_next1" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-1" class="cycle-circle-pager"></div><div id="image-caption-NBP2-24486"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Equine">Eq</span>, <span title="Opossum">Ma-Op</span>, <span title="Primate">Pm</span>, <span title="Xenopus">Xp</span>, <span title="Rat">Rt</span>, <span title="Bovine">Bv</span>, <span title="Canine">Ca</span>, <span title="Feline">Fe</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Equine">Eq</span>, <span title="Opossum">Ma-Op</span>, <span title="Primate">Pm</span>, <span title="Xenopus">Xp</span>, <span title="Rat">Rt</span>, <span title="Bovine">Bv</span>, <span title="Canine">Ca</span>, <span title="Feline">Fe</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Western Blot">WB</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Western Blot">WB</span></div><div class="field not3column"><label>Host:</label><div class="value">Rabbit Polyclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Rabbit Polyclonal</div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMG-6446A</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMG-6446A</div><div class="field not3column"><label>Sizes:</label><div class="value">Sample Size Available</div></div><div class="forcol3 bottom_margin"><strong>Sizes:</strong> Sample Size Available</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  <div class="list_expand not3column options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper">Available Conjugates: <div class="expander option_closed"></div></div></div></div> </div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="conjugates">Conjugates</button></div><div class="conjugates_wrapper" data-title="SOX1 Antibody" data-catnum="NBP2-24486"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="NBP2-24486AF350"> <td><a href="/products/sox1-antibody_nbp2-24486af350">Alexa Fluor 350</a></td> <td><a href="/products/sox1-antibody_nbp2-24486af350">NBP2-24486AF350</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486AF405"> <td><a href="/products/sox1-antibody_nbp2-24486af405">Alexa Fluor 405</a></td> <td><a href="/products/sox1-antibody_nbp2-24486af405">NBP2-24486AF405</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486AF488"> <td><a href="/products/sox1-antibody_nbp2-24486af488">Alexa Fluor 488</a></td> <td><a href="/products/sox1-antibody_nbp2-24486af488">NBP2-24486AF488</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486AF532"> <td><a href="/products/sox1-antibody_nbp2-24486af532">Alexa Fluor 532</a></td> <td><a href="/products/sox1-antibody_nbp2-24486af532">NBP2-24486AF532</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486AF594"> <td><a href="/products/sox1-antibody_nbp2-24486af594">Alexa Fluor 594</a></td> <td><a href="/products/sox1-antibody_nbp2-24486af594">NBP2-24486AF594</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486AF647"> <td><a href="/products/sox1-antibody_nbp2-24486af647">Alexa Fluor 647</a></td> <td><a href="/products/sox1-antibody_nbp2-24486af647">NBP2-24486AF647</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486AF700"> <td><a href="/products/sox1-antibody_nbp2-24486af700">Alexa Fluor 700</a></td> <td><a href="/products/sox1-antibody_nbp2-24486af700">NBP2-24486AF700</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486AF750"> <td><a href="/products/sox1-antibody_nbp2-24486af750">Alexa Fluor 750</a></td> <td><a href="/products/sox1-antibody_nbp2-24486af750">NBP2-24486AF750</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486APC"> <td><a href="/products/sox1-antibody_nbp2-24486apc">Allophycocyanin</a></td> <td><a href="/products/sox1-antibody_nbp2-24486apc">NBP2-24486APC</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486B"> <td><a href="/products/sox1-antibody_nbp2-24486b">Biotin</a></td> <td><a href="/products/sox1-antibody_nbp2-24486b">NBP2-24486B</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486CL1"> <td><a href="/products/sox1-antibody_nbp2-24486cl1">CoraFluor 1</a></td> <td><a href="/products/sox1-antibody_nbp2-24486cl1">NBP2-24486CL1</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486UV"> <td><a href="/products/sox1-antibody_nbp2-24486uv">DyLight 350</a></td> <td><a href="/products/sox1-antibody_nbp2-24486uv">NBP2-24486UV</a></td> <td><div class="popup_stock"></div></td> <td><div 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data-sku="NBP2-24486MFV450"> <td><a href="/products/sox1-antibody_nbp2-24486mfv450">mFluor Violet 450 SE</a></td> <td><a href="/products/sox1-antibody_nbp2-24486mfv450">NBP2-24486MFV450</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486MFV500"> <td><a href="/products/sox1-antibody_nbp2-24486mfv500">mFluor Violet 500 SE</a></td> <td><a href="/products/sox1-antibody_nbp2-24486mfv500">NBP2-24486MFV500</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24486MFV610"> <td><a href="/products/sox1-antibody_nbp2-24486mfv610">mFluor Violet 610 SE</a></td> <td><a href="/products/sox1-antibody_nbp2-24486mfv610">NBP2-24486MFV610</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["NBP2-24486AF350","NBP2-24486AF405","NBP2-24486AF488","NBP2-24486AF532","NBP2-24486AF594","NBP2-24486AF647","NBP2-24486AF700","NBP2-24486AF750","NBP2-24486APC","NBP2-24486B","NBP2-24486CL1","NBP2-24486UV","NBP2-24486V","NBP2-24486G","NBP2-24486R","NBP2-24486DL594","NBP2-24486C","NBP2-24486FR","NBP2-24486IR","NBP2-24486H","NBP2-24486JF525","NBP2-24486JF549","NBP2-24486JF646","NBP2-24486JF669","NBP2-24486PE","NBP2-24486PCP","NBP2-24486MFV450","NBP2-24486MFV500","NBP2-24486MFV610"]' data-rendered="false"></div></div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-24486","Product Name":"SOX1 Antibody","Description":"","Reactivity":"Human, Mouse, Equine, Opossum, Primate, Xenopus, Rat, Bovine, Canine, Feline","Applications":"WB","Source":"","Purification":"","Immunogen":"A portion of amino acids 100-150 of human SOX1 was used as the immunogen.","Citations":"1","Purity":"Immunogen affinity purified","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/sox1-antibody_nbp2-24486\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/sox9-antibody_af3075">AF3075</a> </div><h2 class="col3_hdr"><a data-brand="rnd" data-id="AF3075" data-name="SOX9 Antibody [Unconjugated]" data-position="3" class="ecommerce_link" href="/products/sox9-antibody_af3075" title="SOX9 Antibody [Unconjugated]" ><span> SOX9 Antibody [Unconjugated]</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="2 Reviews for this product" href="/products/sox9-antibody_af3075#ReviewsSection"><span class="stars5"></span> (2 Reviews)</a> </div> <div class="segment"> <a title="155 Publications specific to this product" href="/products/sox9-antibody_af3075#PublicationSection"><span class="publications"></span> (155 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>100 μg</strong><span class="product_price" data-sku="AF3075"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/sox9-antibody_af3075">AF3075</a> </div><div id="ss_prev2" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-2" data-cycle-prev="#ss_prev2" data-cycle-next="#ss_next2" data-cycle-caption="#image-caption-AF3075" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/SOX9_AF3075_Western_Blot_21580.jpg" title="Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, KATO-III human gastric carcinoma cell line, COLO 205 human colorectal adenocarcinoma cell line, and Hep3B human hepatocellular carcinoma cell line. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for SOX9 at approximately 75 kDa (as indicated). GAPDH (Catalog # AF5718) is shown as a loading control. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox"> <img src="//images.novusbio.com/images2/SOX9_AF3075_Western_Blot_21580.jpg" title="Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, KATO-III human gastric carcinoma cell line, COLO 205 human colorectal adenocarcinoma cell line, and Hep3B human hepatocellular carcinoma cell line. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for SOX9 at approximately 75 kDa (as indicated). GAPDH (Catalog # AF5718) is shown as a loading control. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." alt="Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, KATO-III human gastric carcinoma cell line, COLO 205 human colorectal adenocarcinoma cell line, and Hep3B human hepatocellular carcinoma cell line. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for SOX9 at approximately 75 kDa (as indicated). GAPDH (Catalog # AF5718) is shown as a loading control. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize2/SOX9_AF3075_Immunocytochemistry_6490.jpg" title="SOX9 was detected in immersion fixed HEK293 human embryonic kidney cell line using 10 µg/mL Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_lightbox"> <img src="//images.novusbio.com/images2/SOX9_AF3075_Immunocytochemistry_6490.jpg" alt="SOX9 was detected in immersion fixed HEK293 human embryonic kidney cell line using 10 µg/mL Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize2/SOX9_AF3075_Immunocytochemistry_15995.jpg" title="SOX9 was detected in immersion fixed BG01V human embryonic stem cells differentiated into early proximal lung progenitor cells using Goat Anti-Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips." class="big_lightbox"> <img src="//images.novusbio.com/images2/SOX9_AF3075_Immunocytochemistry_15995.jpg" alt="SOX9 was detected in immersion fixed BG01V human embryonic stem cells differentiated into early proximal lung progenitor cells using Goat Anti-Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize2/SOX9_AF3075_Simple_Western_22563.jpg" title=" Simple Western lane view shows lysates of normal adjacent tissue and Crohns tissue, loaded at 0.2 mg/mL. A specific band was detected for SOX9 at approximately 107 kDa (as indicated) using 20 µg/mL of Goat Anti-Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system. " class="big_lightbox"> <img src="//images.novusbio.com/images2/SOX9_AF3075_Simple_Western_22563.jpg" alt=" Simple Western lane view shows lysates of normal adjacent tissue and Crohns tissue, loaded at 0.2 mg/mL. A specific band was detected for SOX9 at approximately 107 kDa (as indicated) using 20 µg/mL of Goat Anti-Human SOX9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3075) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system. " class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-4120241032148.jpg" title="Comparison of E12.5 Sox9IE/IE and Sox9FE/FE embryos based on EGFP intensity and Western blotting.(A) Left panel: white light images of E12.5 Sox9IE/IE and Sox9FE/FE embryos; right panel: same embryos imaged by fluorescence microscopy showed a higher EGFP fluorescence in the Sox9FE/FE embryo compared to the Sox9IE/IE embryo, with EGFP expression in Sox9-specific domains in both. (B) Mean overall EGFP fluorescence of E12.5 Sox9IE/IE (13880.04±1015.55; n = 8) and Sox9FE/FE (84579.48±2822.09; n = 4) embryos analyzed by flow cytometry. Overall EGFP fluorescence was calculated by multiplying the MFI and percentage of EGFP-positive cells. Two-tailed Student's T test, ***p<0.0001. (C) Western blot analysis of E12.5 Sox9IE/IE and Sox9FE/FE embryo lysates, resolved on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) gels and immunoblotted with anti-Sox9 (upper panel) and anti-GFP (middle panel) antibodies. In the upper panel, Sox9-EGFP fusion protein and Sox9-2A (2A - residual 23 amino acids of F2A) was only detected in the Sox9FE/FE embryo lysate, but not in the CD-1 WT or Sox9IE/IE embryo lysates. Middle panel: Sox9-EGFP fusion protein was not detected in the Sox9FE/FE embryos but EGFP was detected in both the Sox9IE/IE and Sox9FE/FE lysates at predicted molecular weight. CD-1 WT lysate served as negative control for EGFP. Bottom panel: immunoblotting with anti-histone antibody showed equal loading. WT – wild-type. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0028885), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-4120241032148.jpg" alt="Comparison of E12.5 Sox9IE/IE and Sox9FE/FE embryos based on EGFP intensity and Western blotting.(A) Left panel: white light images of E12.5 Sox9IE/IE and Sox9FE/FE embryos; right panel: same embryos imaged by fluorescence microscopy showed a higher EGFP fluorescence in the Sox9FE/FE embryo compared to the Sox9IE/IE embryo, with EGFP expression in Sox9-specific domains in both. (B) Mean overall EGFP fluorescence of E12.5 Sox9IE/IE (13880.04±1015.55; n = 8) and Sox9FE/FE (84579.48±2822.09; n = 4) embryos analyzed by flow cytometry. Overall EGFP fluorescence was calculated by multiplying the MFI and percentage of EGFP-positive cells. Two-tailed Student's T test, ***p<0.0001. (C) Western blot analysis of E12.5 Sox9IE/IE and Sox9FE/FE embryo lysates, resolved on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) gels and immunoblotted with anti-Sox9 (upper panel) and anti-GFP (middle panel) antibodies. In the upper panel, Sox9-EGFP fusion protein and Sox9-2A (2A - residual 23 amino acids of F2A) was only detected in the Sox9FE/FE embryo lysate, but not in the CD-1 WT or Sox9IE/IE embryo lysates. Middle panel: Sox9-EGFP fusion protein was not detected in the Sox9FE/FE embryos but EGFP was detected in both the Sox9IE/IE and Sox9FE/FE lysates at predicted molecular weight. CD-1 WT lysate served as negative control for EGFP. Bottom panel: immunoblotting with anti-histone antibody showed equal loading. WT – wild-type. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0028885), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410325582.jpg" title="Dbx1‐expressing progenitors give rise to preBötC neurons and glia. A. Confocal images of Dbx1CreERT2; Rosa26tdTomato mouse preBötC sections immunostained for NeuN. Dbx1‐derived neurons (white arrowhead) expressed tdTomato and were immunoreactive for NeuN. Dbx1‐derived glia (gray arrowhead) expressed tdTomato and were not immunoreactive for NeuN. B. Confocal images of Dbx1CreERT2; Rosa26tdTomato mouse preBötC sections 72 h after injection with AAV‐hSyn‐GFP. Dbx1‐derived non‐neuronal cells extend diffuse fibrils that are closely apposed to the outer surface of microvasculature (white arrows). C, Confocal images of Dbx1CreERT2; Rosa26tdTomato mouse preBötC sections immunostained for Sox9. Glia (gray arrowheads) were immunoreactive for Sox9. Dbx1‐derived neurons (white arrowhead) expressed tdTomato but were not immunoreactive for Sox9. Dbx1‐derived glia expressed tdTomato and were immunoreactive for Sox9 (see “overlay” panel). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28611151), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410325582.jpg" alt="Dbx1‐expressing progenitors give rise to preBötC neurons and glia. A. Confocal images of Dbx1CreERT2; Rosa26tdTomato mouse preBötC sections immunostained for NeuN. Dbx1‐derived neurons (white arrowhead) expressed tdTomato and were immunoreactive for NeuN. Dbx1‐derived glia (gray arrowhead) expressed tdTomato and were not immunoreactive for NeuN. B. Confocal images of Dbx1CreERT2; Rosa26tdTomato mouse preBötC sections 72 h after injection with AAV‐hSyn‐GFP. Dbx1‐derived non‐neuronal cells extend diffuse fibrils that are closely apposed to the outer surface of microvasculature (white arrows). C, Confocal images of Dbx1CreERT2; Rosa26tdTomato mouse preBötC sections immunostained for Sox9. Glia (gray arrowheads) were immunoreactive for Sox9. Dbx1‐derived neurons (white arrowhead) expressed tdTomato but were not immunoreactive for Sox9. Dbx1‐derived glia expressed tdTomato and were immunoreactive for Sox9 (see “overlay” panel). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28611151), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-4120241033837.jpg" title="Feeder-free expansion of SOX9+ BCs. (A) Immunostaining of SOX9+ BCs with anti-P63, anti-KRT5 and anti-SOX9 antibodies. (B) SOX9+ BCs in rugae of 3rd order human airway by anti-SOX9, anti-P63 and anti-CC10 immunostaining. Scale bar, 100 μm. (C) SOX9+ BCs in rugae of 3rd order human airway by anti-KI67 immunostaining. (D) BC colony cultured on feeder-free condition. (E) Karyotyping of cultured BCs. (F) qPCR showing alveolar and bronchial epithelium marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (G) qPCR showing progenitor cell marker (Krt5, P63 and SOX9) gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (H) Western blotting showing marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-4120241033837.jpg" alt="Feeder-free expansion of SOX9+ BCs. (A) Immunostaining of SOX9+ BCs with anti-P63, anti-KRT5 and anti-SOX9 antibodies. (B) SOX9+ BCs in rugae of 3rd order human airway by anti-SOX9, anti-P63 and anti-CC10 immunostaining. Scale bar, 100 μm. (C) SOX9+ BCs in rugae of 3rd order human airway by anti-KI67 immunostaining. (D) BC colony cultured on feeder-free condition. (E) Karyotyping of cultured BCs. (F) qPCR showing alveolar and bronchial epithelium marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (G) qPCR showing progenitor cell marker (Krt5, P63 and SOX9) gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (H) Western blotting showing marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410333016.jpg" title="Transplantated SOX9+ BCs regenerate functional human lungin vivo. (A) Left, direct fluorescence image under stereomicroscope showing NOD-SCID mouse lung without (upper panel) or with (lower panel) GFP-labeled SOX9+ BC transplantation. Right, cryo-section and direct fluorescence imaging of transplanted GFP-labeled SOX9+ BCs in lung parenchyma. Scale bar, 100 μm. (B) Immunofluorescence imaging of transplanted GFP-labeled SOX9+ BCs in lung parenchyma with human specific Lamin A+C marker costaining. (C) Fully differentiated GFP+ cells lost SOX9 marker expression (arrowhead indicated). Scale bar, 10 μm. (D) Confocal image with human specific Lamin A+C immunostaining (HuLamin) showing regenerated type I (AQP5+) alveolar cells. No type II (SPC+) cells were observed. (E) Confocal image showing regenerated AEC1 (AQP5+ and HOPX+). AQP5 as a membrane-bound protein distributes on surface of GFP+ cells. Arrowheads indicated the overlay of HOPX with GFP signal in nucleus. Scale bar, 20 μm. (F) qPCR with human specific primers showing alveolar and bronchiolar epithelium marker gene expression in SOX9+ BC transplanted chimeric lung (AEC1: AQP5 and HOPX; AEC2: SPB and LAMP3; bronchiolar cells: SCGB1A1 and MUC1). Biological replicates, n = 3. Error bars, S.E.M. (G) Left, clonogenic BCs isolated from human cervix epithelium obtained by biopsy. Right, transplantation of equal numbers of BCs from lung and cervix indicated different incorporation efficiency Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410333016.jpg" alt="Transplantated SOX9+ BCs regenerate functional human lungin vivo. (A) Left, direct fluorescence image under stereomicroscope showing NOD-SCID mouse lung without (upper panel) or with (lower panel) GFP-labeled SOX9+ BC transplantation. Right, cryo-section and direct fluorescence imaging of transplanted GFP-labeled SOX9+ BCs in lung parenchyma. Scale bar, 100 μm. (B) Immunofluorescence imaging of transplanted GFP-labeled SOX9+ BCs in lung parenchyma with human specific Lamin A+C marker costaining. (C) Fully differentiated GFP+ cells lost SOX9 marker expression (arrowhead indicated). Scale bar, 10 μm. (D) Confocal image with human specific Lamin A+C immunostaining (HuLamin) showing regenerated type I (AQP5+) alveolar cells. No type II (SPC+) cells were observed. (E) Confocal image showing regenerated AEC1 (AQP5+ and HOPX+). AQP5 as a membrane-bound protein distributes on surface of GFP+ cells. Arrowheads indicated the overlay of HOPX with GFP signal in nucleus. Scale bar, 20 μm. (F) qPCR with human specific primers showing alveolar and bronchiolar epithelium marker gene expression in SOX9+ BC transplanted chimeric lung (AEC1: AQP5 and HOPX; AEC2: SPB and LAMP3; bronchiolar cells: SCGB1A1 and MUC1). Biological replicates, n = 3. Error bars, S.E.M. (G) Left, clonogenic BCs isolated from human cervix epithelium obtained by biopsy. Right, transplantation of equal numbers of BCs from lung and cervix indicated different incorporation efficiency Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410333024.jpg" title="Feeder-free expansion of SOX9+ BCs. (A) Immunostaining of SOX9+ BCs with anti-P63, anti-KRT5 and anti-SOX9 antibodies. (B) SOX9+ BCs in rugae of 3rd order human airway by anti-SOX9, anti-P63 and anti-CC10 immunostaining. Scale bar, 100 μm. (C) SOX9+ BCs in rugae of 3rd order human airway by anti-KI67 immunostaining. (D) BC colony cultured on feeder-free condition. (E) Karyotyping of cultured BCs. (F) qPCR showing alveolar and bronchial epithelium marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (G) qPCR showing progenitor cell marker (Krt5, P63 and SOX9) gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (H) Western blotting showing marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410333024.jpg" alt="Feeder-free expansion of SOX9+ BCs. (A) Immunostaining of SOX9+ BCs with anti-P63, anti-KRT5 and anti-SOX9 antibodies. (B) SOX9+ BCs in rugae of 3rd order human airway by anti-SOX9, anti-P63 and anti-CC10 immunostaining. Scale bar, 100 μm. (C) SOX9+ BCs in rugae of 3rd order human airway by anti-KI67 immunostaining. (D) BC colony cultured on feeder-free condition. (E) Karyotyping of cultured BCs. (F) qPCR showing alveolar and bronchial epithelium marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (G) qPCR showing progenitor cell marker (Krt5, P63 and SOX9) gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (H) Western blotting showing marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410325531.jpg" title="Feeder-free expansion of SOX9+ BCs. (A) Immunostaining of SOX9+ BCs with anti-P63, anti-KRT5 and anti-SOX9 antibodies. (B) SOX9+ BCs in rugae of 3rd order human airway by anti-SOX9, anti-P63 and anti-CC10 immunostaining. Scale bar, 100 μm. (C) SOX9+ BCs in rugae of 3rd order human airway by anti-KI67 immunostaining. (D) BC colony cultured on feeder-free condition. (E) Karyotyping of cultured BCs. (F) qPCR showing alveolar and bronchial epithelium marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (G) qPCR showing progenitor cell marker (Krt5, P63 and SOX9) gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (H) Western blotting showing marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-41202410325531.jpg" alt="Feeder-free expansion of SOX9+ BCs. (A) Immunostaining of SOX9+ BCs with anti-P63, anti-KRT5 and anti-SOX9 antibodies. (B) SOX9+ BCs in rugae of 3rd order human airway by anti-SOX9, anti-P63 and anti-CC10 immunostaining. Scale bar, 100 μm. (C) SOX9+ BCs in rugae of 3rd order human airway by anti-KI67 immunostaining. (D) BC colony cultured on feeder-free condition. (E) Karyotyping of cultured BCs. (F) qPCR showing alveolar and bronchial epithelium marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (G) qPCR showing progenitor cell marker (Krt5, P63 and SOX9) gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages. n = 3, biological replicates. Error bars, S.E.M. (H) Western blotting showing marker gene expression of human lung sample and SOX9+ BCs in early (P2) and late (P8) passages Image collected and cropped by CiteAb from the following publication (//academic.oup.com/proteincell/article/9/3/267/6760074), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721191.jpg" title="Evolution of alveolar epithelial gene expression patterns in the developing mouse lung. Sections of E15.5, 16.5, 17.5 and 18.5 wild-type mouse lungs stained for markers of differentiation. (A) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, LPCAT1 (tip cells from E16.5, then AT2 cells). (B) Green, CEBPA (sub-set of tip cells from E16.5, then AT2 cells); red, pro-SFTPC (embryonic epithelium, stronger from E16.5, later specific to AT2 cells). (C) Green, pro-SFTPC (stronger from E16.5, later specific to AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (D) Green, LPCAT1 (tip cells from E16.5, then AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (E) Green, HOPX (stalk cells from E16.5, AT1 cells); red, SOX9 (tip cells); white, E-CAD (epithelial cells). (F) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, HOPX (stalk cells from E16.5, AT1 cells). (G) Green, HOPX (stalk cells from E16.5, AT1 cells); red, LPCAT1 (tip cells from E16.5, then AT2 cells). Arrows, LPCAT1+ HOPX+ cells; arrowheads, LPCAT1+ HOPX− cells. Blue, DAPI (nuclei). Dashed line, edge of lung. Scale bars: 50 μm in A-F, 20 μm in G and insets. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721191.jpg" alt="Evolution of alveolar epithelial gene expression patterns in the developing mouse lung. Sections of E15.5, 16.5, 17.5 and 18.5 wild-type mouse lungs stained for markers of differentiation. (A) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, LPCAT1 (tip cells from E16.5, then AT2 cells). (B) Green, CEBPA (sub-set of tip cells from E16.5, then AT2 cells); red, pro-SFTPC (embryonic epithelium, stronger from E16.5, later specific to AT2 cells). (C) Green, pro-SFTPC (stronger from E16.5, later specific to AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (D) Green, LPCAT1 (tip cells from E16.5, then AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (E) Green, HOPX (stalk cells from E16.5, AT1 cells); red, SOX9 (tip cells); white, E-CAD (epithelial cells). (F) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, HOPX (stalk cells from E16.5, AT1 cells). (G) Green, HOPX (stalk cells from E16.5, AT1 cells); red, LPCAT1 (tip cells from E16.5, then AT2 cells). Arrows, LPCAT1+ HOPX+ cells; arrowheads, LPCAT1+ HOPX− cells. Blue, DAPI (nuclei). Dashed line, edge of lung. Scale bars: 50 μm in A-F, 20 μm in G and insets. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721165.jpg" title="Glucocorticoid signalling is sufficient, but not essential, to specify alveolar fate. (A) Experimental design: Tomato+ E12.5 or 16.5 tip or stalk was grafted into E12.5 host lung and grown with 50 nM Dx throughout culture. (B) Examples of alveolar-fated tip grafts stained for: green, LPCAT1 (alveolar fate); red, Tomato (graft); white, PDPN (basal and AT1 cells). Arrowheads, PDPN+ AT1 cells. (C) Split bar graph showing results from B. Each type of graft was analysed in at least three independent experiments. (D) E12.5 wild-type lungs were grown with or without Dx for up to 6 days; two independent experimental replicates. Note precocious expression of alveolar markers in the presence of Dx. Lungs cultured without Dx do express LPCAT1 from experimental day 5. Green, LPCAT1 (late tip progenitors and type 2 cells); red, SOX9 (tip progenitors). (E,F) Sections of GR−/− and GR+/+ sibling lungs at E17.5 and E18.5 stained for: green, HOPX (AT1 cells); red, SOX9 (tip progenitors); white, E-CAD (epithelium) (E), and: green, LPCAT1 (late tip progenitors and AT2 cells); red, LAMP3 (AT2 cells); magenta, PDPN (late tip progenitors and AT1 cells) (F). A total of five GR−/− and 5 GR+/+ sibling lungs from three independent litters were observed at both E17.5 and E18.5. Blue, DAPI. Dashed line, edge of lung. Scale bars: 100 μm in B; 50 μm in D-F. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721165.jpg" alt="Glucocorticoid signalling is sufficient, but not essential, to specify alveolar fate. (A) Experimental design: Tomato+ E12.5 or 16.5 tip or stalk was grafted into E12.5 host lung and grown with 50 nM Dx throughout culture. (B) Examples of alveolar-fated tip grafts stained for: green, LPCAT1 (alveolar fate); red, Tomato (graft); white, PDPN (basal and AT1 cells). Arrowheads, PDPN+ AT1 cells. (C) Split bar graph showing results from B. Each type of graft was analysed in at least three independent experiments. (D) E12.5 wild-type lungs were grown with or without Dx for up to 6 days; two independent experimental replicates. Note precocious expression of alveolar markers in the presence of Dx. Lungs cultured without Dx do express LPCAT1 from experimental day 5. Green, LPCAT1 (late tip progenitors and type 2 cells); red, SOX9 (tip progenitors). (E,F) Sections of GR−/− and GR+/+ sibling lungs at E17.5 and E18.5 stained for: green, HOPX (AT1 cells); red, SOX9 (tip progenitors); white, E-CAD (epithelium) (E), and: green, LPCAT1 (late tip progenitors and AT2 cells); red, LAMP3 (AT2 cells); magenta, PDPN (late tip progenitors and AT1 cells) (F). A total of five GR−/− and 5 GR+/+ sibling lungs from three independent litters were observed at both E17.5 and E18.5. Blue, DAPI. Dashed line, edge of lung. Scale bars: 100 μm in B; 50 μm in D-F. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721139.jpg" title="Evolution of alveolar epithelial gene expression patterns in the developing mouse lung. Sections of E15.5, 16.5, 17.5 and 18.5 wild-type mouse lungs stained for markers of differentiation. (A) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, LPCAT1 (tip cells from E16.5, then AT2 cells). (B) Green, CEBPA (sub-set of tip cells from E16.5, then AT2 cells); red, pro-SFTPC (embryonic epithelium, stronger from E16.5, later specific to AT2 cells). (C) Green, pro-SFTPC (stronger from E16.5, later specific to AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (D) Green, LPCAT1 (tip cells from E16.5, then AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (E) Green, HOPX (stalk cells from E16.5, AT1 cells); red, SOX9 (tip cells); white, E-CAD (epithelial cells). (F) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, HOPX (stalk cells from E16.5, AT1 cells). (G) Green, HOPX (stalk cells from E16.5, AT1 cells); red, LPCAT1 (tip cells from E16.5, then AT2 cells). Arrows, LPCAT1+ HOPX+ cells; arrowheads, LPCAT1+ HOPX− cells. Blue, DAPI (nuclei). Dashed line, edge of lung. Scale bars: 50 μm in A-F, 20 μm in G and insets. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721139.jpg" alt="Evolution of alveolar epithelial gene expression patterns in the developing mouse lung. Sections of E15.5, 16.5, 17.5 and 18.5 wild-type mouse lungs stained for markers of differentiation. (A) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, LPCAT1 (tip cells from E16.5, then AT2 cells). (B) Green, CEBPA (sub-set of tip cells from E16.5, then AT2 cells); red, pro-SFTPC (embryonic epithelium, stronger from E16.5, later specific to AT2 cells). (C) Green, pro-SFTPC (stronger from E16.5, later specific to AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (D) Green, LPCAT1 (tip cells from E16.5, then AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (E) Green, HOPX (stalk cells from E16.5, AT1 cells); red, SOX9 (tip cells); white, E-CAD (epithelial cells). (F) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, HOPX (stalk cells from E16.5, AT1 cells). (G) Green, HOPX (stalk cells from E16.5, AT1 cells); red, LPCAT1 (tip cells from E16.5, then AT2 cells). Arrows, LPCAT1+ HOPX+ cells; arrowheads, LPCAT1+ HOPX− cells. Blue, DAPI (nuclei). Dashed line, edge of lung. Scale bars: 50 μm in A-F, 20 μm in G and insets. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721128.jpg" title="Glucocorticoid signalling is sufficient, but not essential, to specify alveolar fate. (A) Experimental design: Tomato+ E12.5 or 16.5 tip or stalk was grafted into E12.5 host lung and grown with 50 nM Dx throughout culture. (B) Examples of alveolar-fated tip grafts stained for: green, LPCAT1 (alveolar fate); red, Tomato (graft); white, PDPN (basal and AT1 cells). Arrowheads, PDPN+ AT1 cells. (C) Split bar graph showing results from B. Each type of graft was analysed in at least three independent experiments. (D) E12.5 wild-type lungs were grown with or without Dx for up to 6 days; two independent experimental replicates. Note precocious expression of alveolar markers in the presence of Dx. Lungs cultured without Dx do express LPCAT1 from experimental day 5. Green, LPCAT1 (late tip progenitors and type 2 cells); red, SOX9 (tip progenitors). (E,F) Sections of GR−/− and GR+/+ sibling lungs at E17.5 and E18.5 stained for: green, HOPX (AT1 cells); red, SOX9 (tip progenitors); white, E-CAD (epithelium) (E), and: green, LPCAT1 (late tip progenitors and AT2 cells); red, LAMP3 (AT2 cells); magenta, PDPN (late tip progenitors and AT1 cells) (F). A total of five GR−/− and 5 GR+/+ sibling lungs from three independent litters were observed at both E17.5 and E18.5. Blue, DAPI. Dashed line, edge of lung. Scale bars: 100 μm in B; 50 μm in D-F. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241721128.jpg" alt="Glucocorticoid signalling is sufficient, but not essential, to specify alveolar fate. (A) Experimental design: Tomato+ E12.5 or 16.5 tip or stalk was grafted into E12.5 host lung and grown with 50 nM Dx throughout culture. (B) Examples of alveolar-fated tip grafts stained for: green, LPCAT1 (alveolar fate); red, Tomato (graft); white, PDPN (basal and AT1 cells). Arrowheads, PDPN+ AT1 cells. (C) Split bar graph showing results from B. Each type of graft was analysed in at least three independent experiments. (D) E12.5 wild-type lungs were grown with or without Dx for up to 6 days; two independent experimental replicates. Note precocious expression of alveolar markers in the presence of Dx. Lungs cultured without Dx do express LPCAT1 from experimental day 5. Green, LPCAT1 (late tip progenitors and type 2 cells); red, SOX9 (tip progenitors). (E,F) Sections of GR−/− and GR+/+ sibling lungs at E17.5 and E18.5 stained for: green, HOPX (AT1 cells); red, SOX9 (tip progenitors); white, E-CAD (epithelium) (E), and: green, LPCAT1 (late tip progenitors and AT2 cells); red, LAMP3 (AT2 cells); magenta, PDPN (late tip progenitors and AT1 cells) (F). A total of five GR−/− and 5 GR+/+ sibling lungs from three independent litters were observed at both E17.5 and E18.5. Blue, DAPI. Dashed line, edge of lung. Scale bars: 100 μm in B; 50 μm in D-F. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241723625.jpg" title="Evolution of alveolar epithelial gene expression patterns in the developing mouse lung. Sections of E15.5, 16.5, 17.5 and 18.5 wild-type mouse lungs stained for markers of differentiation. (A) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, LPCAT1 (tip cells from E16.5, then AT2 cells). (B) Green, CEBPA (sub-set of tip cells from E16.5, then AT2 cells); red, pro-SFTPC (embryonic epithelium, stronger from E16.5, later specific to AT2 cells). (C) Green, pro-SFTPC (stronger from E16.5, later specific to AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (D) Green, LPCAT1 (tip cells from E16.5, then AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (E) Green, HOPX (stalk cells from E16.5, AT1 cells); red, SOX9 (tip cells); white, E-CAD (epithelial cells). (F) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, HOPX (stalk cells from E16.5, AT1 cells). (G) Green, HOPX (stalk cells from E16.5, AT1 cells); red, LPCAT1 (tip cells from E16.5, then AT2 cells). Arrows, LPCAT1+ HOPX+ cells; arrowheads, LPCAT1+ HOPX− cells. Blue, DAPI (nuclei). Dashed line, edge of lung. Scale bars: 50 μm in A-F, 20 μm in G and insets. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-22820241723625.jpg" alt="Evolution of alveolar epithelial gene expression patterns in the developing mouse lung. Sections of E15.5, 16.5, 17.5 and 18.5 wild-type mouse lungs stained for markers of differentiation. (A) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, LPCAT1 (tip cells from E16.5, then AT2 cells). (B) Green, CEBPA (sub-set of tip cells from E16.5, then AT2 cells); red, pro-SFTPC (embryonic epithelium, stronger from E16.5, later specific to AT2 cells). (C) Green, pro-SFTPC (stronger from E16.5, later specific to AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (D) Green, LPCAT1 (tip cells from E16.5, then AT2 cells); red, LAMP3 (rare tip cells; AT2 cells); magenta, PDPN (tip cells from E16.5, then AT1 cells). (E) Green, HOPX (stalk cells from E16.5, AT1 cells); red, SOX9 (tip cells); white, E-CAD (epithelial cells). (F) Green, SOX2 (differentiating bronchioles); red, SOX9 (tips); white, HOPX (stalk cells from E16.5, AT1 cells). (G) Green, HOPX (stalk cells from E16.5, AT1 cells); red, LPCAT1 (tip cells from E16.5, then AT2 cells). Arrows, LPCAT1+ HOPX+ cells; arrowheads, LPCAT1+ HOPX− cells. Blue, DAPI (nuclei). Dashed line, edge of lung. Scale bars: 50 μm in A-F, 20 μm in G and insets. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/27578791), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/af3075_human-sox9-affinity-purified-polyclonal-ab-812025557255.jpg" title="Validation of stem cell associated proteins after HGF stimulation.A, FACS demonstrated up-regulation of CD49b (240%), CD49f (22%), CD44 (26%), together with down-regulation of CD24 (−69%) after HGF stimulation. Thin gray line represents labelling with secondary antibody only (negative control), thin black line DU145 without HGF, and thick black line DU145 with HGF. B, Western blot showed enhancement of SOX9 expression upon HGF stimulation from 2 to 24 hours. C, FACS demonstrated induction of double-labelled CD44+/CD24− DU145 cells (control 8% versus HGF 26%). Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/22110593), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox"> <img src="//images.novusbio.com/images/af3075_human-sox9-affinity-purified-polyclonal-ab-812025557255.jpg" alt="Validation of stem cell associated proteins after HGF stimulation.A, FACS demonstrated up-regulation of CD49b (240%), CD49f (22%), CD44 (26%), together with down-regulation of CD24 (−69%) after HGF stimulation. Thin gray line represents labelling with secondary antibody only (negative control), thin black line DU145 without HGF, and thick black line DU145 with HGF. B, Western blot showed enhancement of SOX9 expression upon HGF stimulation from 2 to 24 hours. C, FACS demonstrated induction of double-labelled CD44+/CD24− DU145 cells (control 8% versus HGF 26%). Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/22110593), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_thumb" /> </a> </div></div><div id="ss_next2" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-2" class="cycle-circle-pager"></div><div id="image-caption-AF3075"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Simple Western">Simple Western</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Simple Western">Simple Western</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span></div><div class="field not3column"><label>Host:</label><div class="value">Goat Polyclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Goat Polyclonal</div><div class="field not3column"><label>Sizes:</label><div class="value">Sample Size Available</div></div><div class="forcol3 bottom_margin"><strong>Sizes:</strong> Sample Size Available</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  <div class="list_expand not3column options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper">Available Conjugates: <div class="expander option_closed"></div></div></div></div> </div><div class="forcol3 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data-id="NBP2-52943" data-name="SOX9 Antibody (CL0639)" data-position="4" class="ecommerce_link" href="/products/sox9-antibody-cl0639_nbp2-52943" title="SOX9 Antibody (CL0639)" ><span> SOX9 Antibody (CL0639)</span></a><div class="ibubble not3column" title="</span><b>Purity:</b> Protein A purified<br/><b>Immunogen:</b> This antibody was developed against a recombinant protein corresponding to amino acids: SQRTHIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTR<br/><b>Other Names:</b> campomelic dysplasia, autosomal sex-reversal, CMD 1, CMD1, CMPD1, SRA1SRY (sex-determining region Y)-box 9 protein, SRY (sex determining region Y)-box 9, SRY-related HMG-box, gene 9, transcription factor SOX-9<br/>"></div></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Publication specific to this product" href="/products/sox9-antibody-cl0639_nbp2-52943#PublicationSection"><span class="publications"></span> (1 Publication)</a> </div> <div class="segment" style="float:right;"> <strong>0.1 ml</strong><span class="product_price" data-sku="NBP2-52943"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/sox9-antibody-cl0639_nbp2-52943">NBP2-52943</a> </div><div id="ss_prev3" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-3" data-cycle-prev="#ss_prev3" data-cycle-next="#ss_next3" data-cycle-caption="#image-caption-NBP2-52943" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Western-Blot-NBP2-52943-img0011.jpg" title="<b>Genetic Strategies Validation. </b>Western Blot: SOX9 Antibody (CL0639) [NBP2-52943] - 251 Cells transfected with: control siRNA, target specific siRNA probe #1, target specific siRNA probe #2, using Anti-SOX9 monoclonal antibody. Downregulation of antibody signal confirms target specificity. Remaining % intensity, relative control lane, is indicated. Anti-GAPDH monoclonal antibody was used as loading control." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-CL0639-Western-Blot-NBP2-52943-img0011.jpg" title="<b>Genetic Strategies Validation. </b>Western Blot: SOX9 Antibody (CL0639) [NBP2-52943] - 251 Cells transfected with: control siRNA, target specific siRNA probe #1, target specific siRNA probe #2, using Anti-SOX9 monoclonal antibody. Downregulation of antibody signal confirms target specificity. Remaining % intensity, relative control lane, is indicated. Anti-GAPDH monoclonal antibody was used as loading control." alt="Western Blot: SOX9 Antibody (CL0639) [NBP2-52943] - 251 Cells transfected with: control siRNA, target specific siRNA probe #1, target specific siRNA probe #2, using Anti-SOX9 monoclonal antibody. Downregulation of antibody signal confirms target specificity. Remaining % intensity, relative control lane, is indicated. Anti-GAPDH monoclonal antibody was used as loading control." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0018.jpg" title="<b>Genetic Strategies Validation and Orthogonal Strategies Validation.</b>Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Analysis in human cerebral cortex and liver tissues using NBP2-52943antibody. Corresponding SOX9 RNA-seq data are presented for the same tissues." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0018.jpg" alt="<b>Genetic Strategies Validation and Orthogonal Strategies Validation.</b>Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Analysis in human cerebral cortex and liver tissues using NBP2-52943antibody. Corresponding SOX9 RNA-seq data are presented for the same tissues." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunocytochemistry-Immunofluorescence-NBP2-52943-img0016.jpg" title="Immunocytochemistry/Immunofluorescence: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of U-251 cells using the anti-SOX9 monoclonal antibody, showing specific staining in the nucleoplasm in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available). Antibody staining is shown in green." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-CL0639-Immunocytochemistry-Immunofluorescence-NBP2-52943-img0016.jpg" alt="Immunocytochemistry/Immunofluorescence: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of U-251 cells using the anti-SOX9 monoclonal antibody, showing specific staining in the nucleoplasm in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available). Antibody staining is shown in green." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0021.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of human liver shows no nuclear positivity in hepatocytes as expected." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0021.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of human liver shows no nuclear positivity in hepatocytes as expected." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-NBP2-52943-img0013.jpg" title="Immunohistochemistry: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of mouse embryo E11 shows nuclear positivity in the developing neural tube." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-CL0639-Immunohistochemistry-NBP2-52943-img0013.jpg" alt="Immunohistochemistry: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of mouse embryo E11 shows nuclear positivity in the developing neural tube." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-NBP2-52943-img0014.jpg" title="Immunohistochemistry: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of mouse embryo E14 shows nuclear immunoreactivity in the developing eye." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-CL0639-Immunohistochemistry-NBP2-52943-img0014.jpg" alt="Immunohistochemistry: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of mouse embryo E14 shows nuclear immunoreactivity in the developing eye." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0019.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of human cerebral cortex shows moderate to strong nuclear positivity in a subset of glial cells. " class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0019.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of human cerebral cortex shows moderate to strong nuclear positivity in a subset of glial cells. " class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0020.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of human testis shows strong nuclear positivity in a subset of cells in seminiferious ducts." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-CL0639-Immunohistochemistry-Paraffin-NBP2-52943-img0020.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody (CL0639) [NBP2-52943] - Staining of human testis shows strong nuclear positivity in a subset of cells in seminiferious ducts." class="big_thumb" /> </a> </div></div><div id="ss_next3" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-3" class="cycle-circle-pager"></div><div id="image-caption-NBP2-52943"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Knockdown Validated">KD</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Knockdown Validated">KD</span></div><div class="field not3column"><label>Host:</label><div class="value">Mouse Monoclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Mouse Monoclonal</div><div class="field not3column"><label>Sizes:</label><div class="value">Sample Size Available</div></div><div class="forcol3 bottom_margin"><strong>Sizes:</strong> Sample Size Available</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  </div></div><div class="field not3column"><label>Validated by:</label><div class="value">    <span><a href="/5-pillars-validation" class="AtlasGenetic" title="Genetic Strategies"> </a></span> <span><a href="/5-pillars-validation" class="AtlasOrthogonal" title="Orthogonal Strategies"> </a></span>  </div></div><div class="forcol3 bottom_margin"><strong>Validated by:</strong>     <span><a href="/5-pillars-validation" class="AtlasGenetic" title="Genetic Strategies"> </a></span> <span><a href="/5-pillars-validation" class="AtlasOrthogonal" title="Orthogonal Strategies"> </a></span>  </div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP2-52943","Product Name":"SOX9 Antibody (CL0639)","Description":"","Reactivity":"Human, Mouse, Rat","Applications":"WB, ICC\/IF, IHC, KD","Source":"","Purification":"","Immunogen":"This antibody was developed against a recombinant protein corresponding to amino acids: SQRTHIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTR","Citations":"1","Purity":"Protein A purified","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/sox9-antibody-cl0639_nbp2-52943\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/sox9-antibody_nbp1-85551">NBP1-85551</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP1-85551" data-name="SOX9 Antibody" data-position="5" class="ecommerce_link" href="/products/sox9-antibody_nbp1-85551" title="SOX9 Antibody" ><span> SOX9 Antibody</span></a><div class="ibubble not3column" title="</span><b>Purity:</b> Immunogen affinity purified<br/><b>Immunogen:</b> This antibody was developed against Recombinant Protein corresponding to amino acids: SQRTHIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTR<br/><b>Other Names:</b> campomelic dysplasia, autosomal sex-reversal, CMD 1, CMD1, CMPD1, SRA1SRY (sex-determining region Y)-box 9 protein, SRY (sex determining region Y)-box 9, SRY-related HMG-box, gene 9, transcription factor SOX-9<br/>"></div></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/sox9-antibody_nbp1-85551#ReviewsSection"><span class="stars5"></span> (1 Review)</a> </div> <div class="segment"> <a title="25 Publications specific to this product" href="/products/sox9-antibody_nbp1-85551#PublicationSection"><span class="publications"></span> (25 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>0.1 ml</strong><span class="product_price" data-sku="NBP1-85551"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/sox9-antibody_nbp1-85551">NBP1-85551</a> </div><div id="ss_prev4" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-4" data-cycle-prev="#ss_prev4" data-cycle-next="#ss_next4" data-cycle-caption="#image-caption-NBP1-85551" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0034.jpg" title="<b>Orthogonal Strategies Validation. </b>Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining in human testis and skeletal muscle tissues . Corresponding SOX9 RNA-seq data are presented for the same tissues." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0034.jpg" title="<b>Orthogonal Strategies Validation. </b>Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining in human testis and skeletal muscle tissues . Corresponding SOX9 RNA-seq data are presented for the same tissues." alt="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining in human testis and skeletal muscle tissues . Corresponding SOX9 RNA-seq data are presented for the same tissues." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Western-Blot-NBP1-85551-img0035.jpg" title="<b>Genetic Strategies Validation and Orthogonal Strategies Validation.</b>Western Blot: SOX9 Antibody [NBP1-85551] - Analysis in U-251MG cells transfected with control siRNA, target specific siRNA probe #1 and #2, using anti-SOX9 antibody. Remaining relative intensity is presented. Loading control: anti-GAPDH." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Western-Blot-NBP1-85551-img0035.jpg" alt="<b>Genetic Strategies Validation and Orthogonal Strategies Validation.</b>Western Blot: SOX9 Antibody [NBP1-85551] - Analysis in U-251MG cells transfected with control siRNA, target specific siRNA probe #1 and #2, using anti-SOX9 antibody. Remaining relative intensity is presented. Loading control: anti-GAPDH." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-85551-img0037.jpg" title="Immunocytochemistry/Immunofluorescence: SOX9 Antibody [NBP1-85551] - Further analysis of P2X7-EGFP expressing cells in the dentate gyrus and CA1 region. Co-staining of EGFP with the alternative astrocyte marker SOX9 in the CA1 region. Scale bar: 50 um. DAPI staining in blue (n = at least three animals in all experiments). Image collected and cropped by CiteAb from the following publication (//elifesciences.org/articles/36217), licensed under a CC-BY license." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-85551-img0037.jpg" alt="Immunocytochemistry/Immunofluorescence: SOX9 Antibody [NBP1-85551] - Further analysis of P2X7-EGFP expressing cells in the dentate gyrus and CA1 region. Co-staining of EGFP with the alternative astrocyte marker SOX9 in the CA1 region. Scale bar: 50 um. DAPI staining in blue (n = at least three animals in all experiments). Image collected and cropped by CiteAb from the following publication (//elifesciences.org/articles/36217), licensed under a CC-BY license." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Western-Blot-NBP1-85551-img0025.jpg" title="Western Blot: SOX9 Antibody [NBP1-85551] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Western-Blot-NBP1-85551-img0025.jpg" alt="Western Blot: SOX9 Antibody [NBP1-85551] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-85551-img0036.jpg" title="Immunocytochemistry/Immunofluorescence: SOX9 Antibody [NBP1-85551] - Staining of human cell line U-251 MG shows localization to nucleoplasm. Antibody staining is shown in green." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-85551-img0036.jpg" alt="Immunocytochemistry/Immunofluorescence: SOX9 Antibody [NBP1-85551] - Staining of human cell line U-251 MG shows localization to nucleoplasm. Antibody staining is shown in green." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0029.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human colorectal cancer shows moderate to strong nuclear positivity in tumor cells." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0029.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human colorectal cancer shows moderate to strong nuclear positivity in tumor cells." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0030.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human glioma shows moderate to strong nuclear positivity in tumor cells." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0030.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human glioma shows moderate to strong nuclear positivity in tumor cells." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0031.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human skeletal muscle shows no nuclear positivity in striated muscle fibers as expected." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0031.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human skeletal muscle shows no nuclear positivity in striated muscle fibers as expected." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0032.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human small intestine shows moderate nuclear positivity in a subset of glandular cells." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0032.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human small intestine shows moderate nuclear positivity in a subset of glandular cells." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0033.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human testis shows moderate nuclear positivity in a subset of cells in seminiferous ducts." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP1-85551-img0033.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP1-85551] - Staining of human testis shows moderate nuclear positivity in a subset of cells in seminiferous ducts." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Simple-Western-NBP1-85551-img0006.jpg" title="Simple Western: SOX9 Antibody [NBP1-85551] - Simple Western lane view shows a specific band for SOX9 in 0.1 mg/ml of U-251MG sp (left) and HepG2 (right) lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Simple-Western-NBP1-85551-img0006.jpg" alt="Simple Western: SOX9 Antibody [NBP1-85551] - Simple Western lane view shows a specific band for SOX9 in 0.1 mg/ml of U-251MG sp (left) and HepG2 (right) lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Simple-Western-NBP1-85551-img0012.jpg" title="Simple Western: SOX9 Antibody [NBP1-85551] - Electropherogram image(s) of corresponding Simple Western lane view. SOX9 antibody was used at 1:100 dilution on U-251MG sp and HepG2 lysates(s)." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Simple-Western-NBP1-85551-img0012.jpg" alt="Simple Western: SOX9 Antibody [NBP1-85551] - Electropherogram image(s) of corresponding Simple Western lane view. SOX9 antibody was used at 1:100 dilution on U-251MG sp and HepG2 lysates(s)." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/nbp1-85551_rabbit-polyclonal-sox9-antibody-210202423454890.jpg" title="Immunohistochemistry of candidate biomarkers in prostate cancer. Representative immunohistochemical staining of ACPP, ADAM9, ALDH1A2, CASR, CCND1, CCPG1, CD34, CD44, CD44v6, CHGA, CHMP1A, EI24, ENO2, GADD45B, HA, HAS2, HES6, HMMR, HOXC6, HYAL1, IGF1, IQCK, MAP4K4, MKI67, PAGE4, PLIN2, PTEN, SIAH2, SMAD4, SOX9, SPP1, SYP, & TP53 from prostate cancer tissue microarrays. Scale bar represents 50 μm. Image collected & cropped by CiteAb from the following publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-244), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox"> <img src="//images.novusbio.com/images/nbp1-85551_rabbit-polyclonal-sox9-antibody-210202423454890.jpg" alt="Immunohistochemistry of candidate biomarkers in prostate cancer. Representative immunohistochemical staining of ACPP, ADAM9, ALDH1A2, CASR, CCND1, CCPG1, CD34, CD44, CD44v6, CHGA, CHMP1A, EI24, ENO2, GADD45B, HA, HAS2, HES6, HMMR, HOXC6, HYAL1, IGF1, IQCK, MAP4K4, MKI67, PAGE4, PLIN2, PTEN, SIAH2, SMAD4, SOX9, SPP1, SYP, & TP53 from prostate cancer tissue microarrays. Scale bar represents 50 μm. Image collected & cropped by CiteAb from the following publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-244), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_thumb" /> </a> </div></div><div id="ss_next4" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-4" class="cycle-circle-pager"></div><div id="image-caption-NBP1-85551"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Porcine">Po</span>, <span title="Canine">Ca</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Porcine">Po</span>, <span title="Canine">Ca</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Simple Western">Simple Western</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Gel Shift">GS</span>, <span class="application-tooltip-text" title="Knockdown Validated">KD</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Simple Western">Simple Western</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Gel Shift">GS</span>, <span class="application-tooltip-text" title="Knockdown Validated">KD</span></div><div class="field not3column"><label>Host:</label><div class="value">Rabbit Polyclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Rabbit Polyclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  </div></div><div class="field not3column"><label>Validated by:</label><div class="value">    <span><a href="/5-pillars-validation" class="AtlasGenetic" title="Genetic Strategies"> </a></span> <span><a href="/5-pillars-validation" class="AtlasOrthogonal" title="Orthogonal Strategies"> </a></span>  </div></div><div class="forcol3 bottom_margin"><strong>Validated by:</strong>     <span><a href="/5-pillars-validation" class="AtlasGenetic" title="Genetic Strategies"> </a></span> <span><a href="/5-pillars-validation" class="AtlasOrthogonal" title="Orthogonal Strategies"> </a></span>  </div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"NBP1-85551","Product Name":"SOX9 Antibody","Description":"","Reactivity":"Human, Mouse, Rat, Porcine, Canine","Applications":"WB, Simple Western, ICC\/IF, IHC, GS, KD","Source":"","Purification":"","Immunogen":"This antibody was developed against Recombinant Protein corresponding to amino acids: SQRTHIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTR","Citations":"25","Purity":"Immunogen affinity purified","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/sox9-antibody_nbp1-85551\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/sox9-recombinant-protein_h00006662-p01">H00006662-P01</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="H00006662-P01" data-name="Recombinant Human SOX9 GST (N-Term) Protein" data-position="6" class="ecommerce_link" href="/products/sox9-recombinant-protein_h00006662-p01" title="Recombinant Human SOX9 GST (N-Term) Protein" ><span> Recombinant Human SOX9 GST (N-Term) Protein</span></a></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Publication specific to this product" href="/products/sox9-recombinant-protein_h00006662-p01#PublicationSection"><span class="publications"></span> (1 Publication)</a> </div> <div class="segment" style="float:right;"> <strong>10 μg</strong><span class="product_price" data-sku="H00006662-P01-10ug"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/sox9-recombinant-protein_h00006662-p01">H00006662-P01</a> </div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-5" data-cycle-prev="#ss_prev5" data-cycle-next="#ss_next5" data-cycle-caption="#image-caption-H00006662-P01" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/qc_test-H00006662-P01-1.jpg" title="SDS-Page: Recombinant Human SOX9 Protein [H00006662-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue." class="big_lightbox"> <img src="//images.novusbio.com/images/qc_test-H00006662-P01-1.jpg" title="SDS-Page: Recombinant Human SOX9 Protein [H00006662-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue." alt="SDS-Page: Recombinant Human SOX9 Protein [H00006662-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue." class="big_thumb" /> </a> </div></div><div class="pager_fill"></div><div id="image-caption-H00006662-P01"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="ELISA">ELISA</span>, <span class="application-tooltip-text" title="Microarray">MA</span>, <span class="application-tooltip-text" title="SDS-PAGE">PAGE</span>, <span class="application-tooltip-text" title="Affinity Purification">AP</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="ELISA">ELISA</span>, <span class="application-tooltip-text" title="Microarray">MA</span>, <span class="application-tooltip-text" title="SDS-PAGE">PAGE</span>, <span class="application-tooltip-text" title="Affinity Purification">AP</span></div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"H00006662-P01","Product Name":"Recombinant Human SOX9 GST (N-Term) Protein","Description":"","Reactivity":"Human","Applications":"WB, ELISA, MA, PAGE, AP","Source":"","Purification":"","Immunogen":"","Citations":"1","Purity":">80% by SDS-PAGE and Coomassie blue staining","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/sox9-recombinant-protein_h00006662-p01\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/sox9-antibody-3c10_h00006662-m02">H00006662-M02</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="H00006662-M02" data-name="SOX9 Antibody (3C10)" data-position="7" class="ecommerce_link" href="/products/sox9-antibody-3c10_h00006662-m02" title="SOX9 Antibody (3C10)" ><span> SOX9 Antibody (3C10)</span></a><div class="ibubble not3column" title="</span><b>Purity:</b> IgG purified<br/><b>Immunogen:</b> SOX9 (NP_000337, 400 a.a. ~ 509 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. EQLSPSHYSEQQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP<br/><b>Other Names:</b> campomelic dysplasia, autosomal sex-reversal, CMD 1, CMD1, CMPD1, SRA1SRY (sex-determining region Y)-box 9 protein, SRY (sex determining region Y)-box 9, SRY-related HMG-box, gene 9, transcription factor SOX-9<br/>"></div></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/sox9-antibody-3c10_h00006662-m02#ReviewsSection"><span class="stars5"></span> (1 Review)</a> </div> <div class="segment"> <a title="12 Publications specific to this product" href="/products/sox9-antibody-3c10_h00006662-m02#PublicationSection"><span class="publications"></span> (12 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>0.1 mg</strong><span class="product_price" data-sku="H00006662-M02"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/sox9-antibody-3c10_h00006662-m02">H00006662-M02</a> </div><div id="ss_prev6" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-6" data-cycle-prev="#ss_prev6" data-cycle-next="#ss_next6" data-cycle-caption="#image-caption-H00006662-M02" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-3C10-Western-Blot-H00006662-M02-img0013.jpg" title="Western Blot: SOX9 Antibody (3C10) [H00006662-M02] - SOX9 monoclonal antibody (M02), clone 3C10 Analysis of SOX9 expression in HepG2." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-3C10-Western-Blot-H00006662-M02-img0013.jpg" title="Western Blot: SOX9 Antibody (3C10) [H00006662-M02] - SOX9 monoclonal antibody (M02), clone 3C10 Analysis of SOX9 expression in HepG2." alt="Western Blot: SOX9 Antibody (3C10) [H00006662-M02] - SOX9 monoclonal antibody (M02), clone 3C10 Analysis of SOX9 expression in HepG2." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-3C10-Immunocytochemistry-Immunofluorescence-H00006662-M02-img0008.jpg" title="Immunocytochemistry/Immunofluorescence: SOX9 Antibody (3C10) [H00006662-M02] - Analysis of monoclonal antibody to SOX9 on HepG2 cell. Antibody concentration 10 ug/ml." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-3C10-Immunocytochemistry-Immunofluorescence-H00006662-M02-img0008.jpg" alt="Immunocytochemistry/Immunofluorescence: SOX9 Antibody (3C10) [H00006662-M02] - Analysis of monoclonal antibody to SOX9 on HepG2 cell. Antibody concentration 10 ug/ml." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-3C10-Immunohistochemistry-Paraffin-H00006662-M02-img0010.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody (3C10) [H00006662-M02] - Analysis of monoclonal antibody to SOX9 on formalin-fixed paraffin-embedded human tonsil. Antibody concentration 0.7 ug/ml." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-3C10-Immunohistochemistry-Paraffin-H00006662-M02-img0010.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody (3C10) [H00006662-M02] - Analysis of monoclonal antibody to SOX9 on formalin-fixed paraffin-embedded human tonsil. Antibody concentration 0.7 ug/ml." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-3C10-Western-Blot-H00006662-M02-img0014.jpg" title="Western Blot: SOX9 Antibody (3C10) [H00006662-M02] - Analysis of SOX9 expression in transfected 293T cell line by SOX9 monoclonal antibody (M02), clone 3C10.Lane 1: SOX9 transfected lysate(56.1 KDa).Lane 2: Non-transfected lysate." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-3C10-Western-Blot-H00006662-M02-img0014.jpg" alt="Western Blot: SOX9 Antibody (3C10) [H00006662-M02] - Analysis of SOX9 expression in transfected 293T cell line by SOX9 monoclonal antibody (M02), clone 3C10.Lane 1: SOX9 transfected lysate(56.1 KDa).Lane 2: Non-transfected lysate." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-3C10-Immunohistochemistry-Paraffin-H00006662-M02-img0006.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody (3C10) [H00006662-M02] - analysis of SOX9 in formalin-fixed, paraffin-embedded human fetal developing pancreas tissue using anti-SOX9 antibody. Image from verified customer review." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-3C10-Immunohistochemistry-Paraffin-H00006662-M02-img0006.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody (3C10) [H00006662-M02] - analysis of SOX9 in formalin-fixed, paraffin-embedded human fetal developing pancreas tissue using anti-SOX9 antibody. Image from verified customer review." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-3C10-Immunoprecipitation-H00006662-M02-img0011.jpg" title="Immunoprecipitation: SOX9 Antibody (3C10) [H00006662-M02] - Analysis of SOX9 transfected lysate using anti-SOX9 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with SOX9 MaxPab rabbit polyclonal antibody." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-3C10-Immunoprecipitation-H00006662-M02-img0011.jpg" alt="Immunoprecipitation: SOX9 Antibody (3C10) [H00006662-M02] - Analysis of SOX9 transfected lysate using anti-SOX9 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with SOX9 MaxPab rabbit polyclonal antibody." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-3C10-ELISA-H00006662-M02-img0015.jpg" title="ELISA: SOX9 Antibody (3C10) [H00006662-M02] - Detection limit for recombinant GST tagged SOX9 is 0.1 ng/ml as a capture antibody." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-3C10-ELISA-H00006662-M02-img0015.jpg" alt="ELISA: SOX9 Antibody (3C10) [H00006662-M02] - Detection limit for recombinant GST tagged SOX9 is 0.1 ng/ml as a capture antibody." class="big_thumb" /> </a> </div></div><div id="ss_next6" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-6" class="cycle-circle-pager"></div><div id="image-caption-H00006662-M02"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="ELISA">ELISA</span>, <span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Immunoprecipitation">IP</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="ELISA">ELISA</span>, <span class="application-tooltip-text" title="Functional Assay">Func</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span>, <span class="application-tooltip-text" title="Immunoprecipitation">IP</span></div><div class="field not3column"><label>Host:</label><div class="value">Mouse Monoclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Mouse Monoclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  </div></div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"H00006662-M02","Product Name":"SOX9 Antibody (3C10)","Description":"","Reactivity":"Human","Applications":"WB, ELISA, Func, ICC\/IF, IHC, IP","Source":"","Purification":"","Immunogen":"SOX9 (NP_000337, 400 a.a. ~ 509 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. EQLSPSHYSEQQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP","Citations":"12","Purity":"IgG purified","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/sox9-antibody-3c10_h00006662-m02\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/sox9-antibody_nbp2-24659">NBP2-24659</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="NBP2-24659" data-name="SOX9 Antibody" data-position="8" class="ecommerce_link" href="/products/sox9-antibody_nbp2-24659" title="SOX9 Antibody" ><span> SOX9 Antibody</span></a><div class="ibubble not3column" title="</span><b>Purity:</b> Immunogen affinity purified<br/><b>Immunogen:</b> A portion of amino acids 225-275 of human SOX9 was used as the immunogen for this antibody.<br/><b>Other Names:</b> campomelic dysplasia, autosomal sex-reversal, CMD 1, CMD1, CMPD1, SRA1SRY (sex-determining region Y)-box 9 protein, SRY (sex determining region Y)-box 9, SRY-related HMG-box, gene 9, transcription factor SOX-9<br/>"></div></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="1 Review for this product" href="/products/sox9-antibody_nbp2-24659#ReviewsSection"><span class="stars3"></span> (1 Review)</a> </div> <div class="segment"> <a title="4 Publications specific to this product" href="/products/sox9-antibody_nbp2-24659#PublicationSection"><span class="publications"></span> (4 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>0.1 mg</strong><span class="product_price" data-sku="NBP2-24659"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/sox9-antibody_nbp2-24659">NBP2-24659</a> </div><div id="ss_prev7" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-7" data-cycle-prev="#ss_prev7" data-cycle-next="#ss_next7" data-cycle-caption="#image-caption-NBP2-24659" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Simple-Western-NBP2-24659-img0004.jpg" title="Simple Western: SOX9 Antibody [NBP2-24659] - Simple Western lane view shows a specific band for SOX9 in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Simple-Western-NBP2-24659-img0004.jpg" title="Simple Western: SOX9 Antibody [NBP2-24659] - Simple Western lane view shows a specific band for SOX9 in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system." alt="Simple Western: SOX9 Antibody [NBP2-24659] - Simple Western lane view shows a specific band for SOX9 in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-NBP2-24659-img0007.jpg" title="Immunohistochemistry: SOX9 Antibody [NBP2-24659] - Osteo-chondroprogenitor cells in the zone adjacent to the titanium plate surface are positive for Sox9 (arrows). Picture on the left represent Group 0.1, pictures on the right represent Group 0.6. 100-fold (c-d) magnification. PLoS One. 2018 Apr 6;13(4):e0195466. doi: 10.1371/journal.pone.0195466." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunohistochemistry-NBP2-24659-img0007.jpg" alt="Immunohistochemistry: SOX9 Antibody [NBP2-24659] - Osteo-chondroprogenitor cells in the zone adjacent to the titanium plate surface are positive for Sox9 (arrows). Picture on the left represent Group 0.1, pictures on the right represent Group 0.6. 100-fold (c-d) magnification. PLoS One. 2018 Apr 6;13(4):e0195466. doi: 10.1371/journal.pone.0195466." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-NBP2-24659-img0008.jpg" title="<b>Biological Strategies Validation. </b>Immunohistochemistry: SOX9 Antibody [NBP2-24659] - 3'-Sialyllactose regulates anabolic and catabolic factor expression via Erk and NF-kB pathways. (C) Immunohistochemical staining of Sox9 in DMM-induced OA mice with administration of PBS and 3'-sialyllactose. Image collected and cropped by CiteAb from the following publication (//doi.wiley.com/10.1111/jcmm.13292), licensed under a CC-BY license." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunohistochemistry-NBP2-24659-img0008.jpg" alt="<b>Biological Strategies Validation. </b>Immunohistochemistry: SOX9 Antibody [NBP2-24659] - 3'-Sialyllactose regulates anabolic and catabolic factor expression via Erk and NF-kB pathways. (C) Immunohistochemical staining of Sox9 in DMM-induced OA mice with administration of PBS and 3'-sialyllactose. Image collected and cropped by CiteAb from the following publication (//doi.wiley.com/10.1111/jcmm.13292), licensed under a CC-BY license." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Frozen-NBP2-24659-img0005.jpg" title="Immunohistochemistry-Frozen: SOX9 Antibody [NBP2-24659] - Feline optic nerve tissue section was incubated with antibody at 1:200 and further stained with Alexa secondary antibody. Image was captured with an epifluorescence microscope. This image was submitted via customer review." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunohistochemistry-Frozen-NBP2-24659-img0005.jpg" alt="Immunohistochemistry-Frozen: SOX9 Antibody [NBP2-24659] - Feline optic nerve tissue section was incubated with antibody at 1:200 and further stained with Alexa secondary antibody. Image was captured with an epifluorescence microscope. This image was submitted via customer review." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Western-Blot-NBP2-24659-img0003.jpg" title="Western Blot: SOX9 Antibody [NBP2-24659] - Analysis of SOX9 in mouse embryo brain lysate in the 1) absence and 2) presence of immunizing peptide using SOX9 antibody at 2 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Western-Blot-NBP2-24659-img0003.jpg" alt="Western Blot: SOX9 Antibody [NBP2-24659] - Analysis of SOX9 in mouse embryo brain lysate in the 1) absence and 2) presence of immunizing peptide using SOX9 antibody at 2 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Western-Blot-NBP2-24659-img0002.jpg" title="Western Blot: SOX9 Antibody [NBP2-24659] - Analysis of SOX9 in human brain lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse brain and 4) rat brain lysate using SOX9 antibody at 3 ug/ml." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Western-Blot-NBP2-24659-img0002.jpg" alt="Western Blot: SOX9 Antibody [NBP2-24659] - Analysis of SOX9 in human brain lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse brain and 4) rat brain lysate using SOX9 antibody at 3 ug/ml." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP2-24659-img0001.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP2-24659] - Analysis of SOX9 in formalin-fixed, paraffin-embedded mouse testis tissue using an isotype control (top left) and SOX9 antibody (bottom left, right) at 5 ug/ml." class="big_lightbox"> <img src="//images.novusbio.com/images/SOX9-Antibody-Immunohistochemistry-Paraffin-NBP2-24659-img0001.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP2-24659] - Analysis of SOX9 in formalin-fixed, paraffin-embedded mouse testis tissue using an isotype control (top left) and SOX9 antibody (bottom left, right) at 5 ug/ml." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/nbp2-24659_rabbit-polyclonal-sox9-antibody-310202416113513.jpg" title="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP2-24659] - 3′‐Sialyllactose regulates anabolic & catabolic factor expression via Erk & NF‐ kappa B pathways. (A, B) Chondrocytes were pre‐treated with different concentrations of 3′‐sialyllactose for 24 hrs prior to treatment with IL‐1 beta (5 ng/ml) for 10 min. Erk phosphorylation was measured by Western blotting (A, upper panel) & densitometry (A, lower panel). The protein level of I kappa B was detected by Western blotting (B, upper panel) & densitometry (B, lower panel). Erk was detected as a loading control. (C) Immunohistochemical staining of Sox9, I kappa B & pErk in DMM‐induced OA mice with administration of PBS & 3′‐sialyllactose. (D) Schematic diagram of the signalling pathway leading to Sox9 activation & NF‐ kappa B inhibition by 3′‐sialyllactose. Values represent the means ± S.E.M. *P < 0.05. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28782172), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox"> <img src="//images.novusbio.com/images/nbp2-24659_rabbit-polyclonal-sox9-antibody-310202416113513.jpg" alt="Immunohistochemistry-Paraffin: SOX9 Antibody [NBP2-24659] - 3′‐Sialyllactose regulates anabolic & catabolic factor expression via Erk & NF‐ kappa B pathways. (A, B) Chondrocytes were pre‐treated with different concentrations of 3′‐sialyllactose for 24 hrs prior to treatment with IL‐1 beta (5 ng/ml) for 10 min. Erk phosphorylation was measured by Western blotting (A, upper panel) & densitometry (A, lower panel). The protein level of I kappa B was detected by Western blotting (B, upper panel) & densitometry (B, lower panel). Erk was detected as a loading control. (C) Immunohistochemical staining of Sox9, I kappa B & pErk in DMM‐induced OA mice with administration of PBS & 3′‐sialyllactose. (D) Schematic diagram of the signalling pathway leading to Sox9 activation & NF‐ kappa B inhibition by 3′‐sialyllactose. Values represent the means ± S.E.M. *P < 0.05. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28782172), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_thumb" /> </a> </div></div><div id="ss_next7" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-7" class="cycle-circle-pager"></div><div id="image-caption-NBP2-24659"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Canine">Ca</span>, <span title="Feline">Fe</span>, <span title="Goat">Gt</span>, <span title="Primate">Pm</span>, <span title="Sheep">Sh</span>, <span title="Bovine">Bv</span>, <span title="Chimpanzee">Pm</span>, <span title="Equine">Eq</span>, <span title="Monkey">Pm</span>, <span title="Opossum">Ma-Op</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span>, <span title="Mouse">Mu</span>, <span title="Rat">Rt</span>, <span title="Canine">Ca</span>, <span title="Feline">Fe</span>, <span title="Goat">Gt</span>, <span title="Primate">Pm</span>, <span title="Sheep">Sh</span>, <span title="Bovine">Bv</span>, <span title="Chimpanzee">Pm</span>, <span title="Equine">Eq</span>, <span title="Monkey">Pm</span>, <span title="Opossum">Ma-Op</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Simple Western">Simple Western</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="Simple Western">Simple Western</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span></div><div class="field not3column"><label>Host:</label><div class="value">Rabbit Polyclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Rabbit Polyclonal</div><div class="field not3column"><label>Alt Catalog#</label><div class="value">IMG-6489A</div></div><div class="forcol3 bottom_margin"><strong>Alt Catalog#</strong> IMG-6489A</div><div class="field not3column"><label>Sizes:</label><div class="value">Sample Size Available</div></div><div class="forcol3 bottom_margin"><strong>Sizes:</strong> Sample Size Available</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  <div class="list_expand not3column options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper">Available Conjugates: <div class="expander option_closed"></div></div></div></div><div class="field not3column"><label>Validated by:</label><div class="value">  <span><a href="/5-pillars-validation" class="AtlasBiological" title="Biological Strategies"> </a></span>      </div></div><div class="forcol3 bottom_margin"><strong>Validated by:</strong>   <span><a href="/5-pillars-validation" class="AtlasBiological" title="Biological Strategies"> </a></span>      </div> </div><div class="forcol3 option_buttons_block"><button class="options_button" data-type="conjugates">Conjugates</button></div><div class="conjugates_wrapper" data-title="SOX9 Antibody" data-catnum="NBP2-24659"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="NBP2-24659AF350"> <td><a href="/products/sox9-antibody_nbp2-24659af350">Alexa Fluor 350</a></td> <td><a href="/products/sox9-antibody_nbp2-24659af350">NBP2-24659AF350</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div 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class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24659AF594"> <td><a href="/products/sox9-antibody_nbp2-24659af594">Alexa Fluor 594</a></td> <td><a href="/products/sox9-antibody_nbp2-24659af594">NBP2-24659AF594</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24659AF647"> <td><a href="/products/sox9-antibody_nbp2-24659af647">Alexa Fluor 647</a></td> <td><a href="/products/sox9-antibody_nbp2-24659af647">NBP2-24659AF647</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24659AF700"> <td><a href="/products/sox9-antibody_nbp2-24659af700">Alexa Fluor 700</a></td> <td><a 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href="/products/sox9-antibody_nbp2-24659b">Biotin</a></td> <td><a href="/products/sox9-antibody_nbp2-24659b">NBP2-24659B</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24659CL1"> <td><a href="/products/sox9-antibody_nbp2-24659cl1">CoraFluor 1</a></td> <td><a href="/products/sox9-antibody_nbp2-24659cl1">NBP2-24659CL1</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24659UV"> <td><a href="/products/sox9-antibody_nbp2-24659uv">DyLight 350</a></td> <td><a href="/products/sox9-antibody_nbp2-24659uv">NBP2-24659UV</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24659V"> <td><a href="/products/sox9-antibody_nbp2-24659v">DyLight 405</a></td> <td><a href="/products/sox9-antibody_nbp2-24659v">NBP2-24659V</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24659G"> <td><a href="/products/sox9-antibody_nbp2-24659g">DyLight 488</a></td> <td><a href="/products/sox9-antibody_nbp2-24659g">NBP2-24659G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NBP2-24659R"> <td><a href="/products/sox9-antibody_nbp2-24659r">DyLight 550</a></td> <td><a href="/products/sox9-antibody_nbp2-24659r">NBP2-24659R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" 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data-compare='{"Catalog #":"NBP2-24659","Product Name":"SOX9 Antibody","Description":"","Reactivity":"Human, Mouse, Rat, Canine, Feline, Goat, Primate, Sheep, Bovine, Chimpanzee, Equine, Monkey, Opossum","Applications":"WB, Simple Western, IHC","Source":"","Purification":"","Immunogen":"A portion of amino acids 225-275 of human SOX9 was used as the immunogen for this antibody.","Citations":"4","Purity":"Immunogen affinity purified","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/sox9-antibody_nbp2-24659\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div><div class="new-search-result search-result-wrapper" > <div class="name"><span> <div class="catalog_number_wrapper not3column"> <a href="/products/braf35-antibody-1f6_h00010362-m01">H00010362-M01</a> </div><h2 class="col3_hdr"><a data-brand="novus" data-id="H00010362-M01" data-name="BRAF35 Antibody (1F6)" data-position="9" class="ecommerce_link" href="/products/braf35-antibody-1f6_h00010362-m01" title="BRAF35 Antibody (1F6)" ><span> BRAF35 Antibody (1F6)</span></a><div class="ibubble not3column" title="</span><b>Purity:</b> IgG purified<br/><b>Immunogen:</b> HMG20B (NP_006330, 1 a.a. ~ 109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MLGAEWSKLQPTEKQRYLDEAEREKQQYMKELRAYQQSEAYKMCTEKIQEKKIKKEDSSSGLMNTLLNGHKGGDCDGFSTFDVPIFTEEFLDQNKAREAELRRLRKMNV<br/><b>Other Names:</b> BRAF35Sox-like transcriptional factor, high-mobility group 20B, HMG domain-containing protein 2, HMG domain-containing protein HMGX2, HMGX2FLJ26127, HMGXB2member 1-related, SMARCE1R, SMARCE1-related protein<br/>"></div></div></h2> <div class="sub-header"> <div class="flourish_left"></div> <div class="flourish_right"></div><div class="prod_details_section"> <div class="segment"> <a title="3 Publications specific to this product" href="/products/braf35-antibody-1f6_h00010362-m01#PublicationSection"><span class="publications"></span> (3 Publications)</a> </div> <div class="segment" style="float:right;"> <strong>0.1 mg</strong><span class="product_price" data-sku="H00010362-M01"></span> </div> </div> </div> <div class="images"> <div class="catalog_number_wrapper_col3 forcol3"> <a href="/products/braf35-antibody-1f6_h00010362-m01">H00010362-M01</a> </div><div id="ss_prev8" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-8" data-cycle-prev="#ss_prev8" data-cycle-next="#ss_next8" data-cycle-caption="#image-caption-H00010362-M01" data-cycle-caption-template="Image {{slideNum}} / {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/BRAF35-Antibody-1F6-Western-Blot-H00010362-M01-img0010.jpg" title="Western Blot: BRAF35 Antibody (1F6) [H00010362-M01] - HMG20B monoclonal antibody (M01), clone IF6 Analysis of HMG20B expression in HeLa." class="big_lightbox"> <img src="//images.novusbio.com/images/BRAF35-Antibody-1F6-Western-Blot-H00010362-M01-img0010.jpg" title="Western Blot: BRAF35 Antibody (1F6) [H00010362-M01] - HMG20B monoclonal antibody (M01), clone IF6 Analysis of HMG20B expression in HeLa." alt="Western Blot: BRAF35 Antibody (1F6) [H00010362-M01] - HMG20B monoclonal antibody (M01), clone IF6 Analysis of HMG20B expression in HeLa." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/BRAF35-Antibody-1F6-Immunocytochemistry-Immunofluorescence-H00010362-M01-img0007.jpg" title="Immunocytochemistry/Immunofluorescence: BRAF35 Antibody (1F6) [H00010362-M01] - Analysis of monoclonal antibody to HMG20B on HeLa cell. Antibody concentration 10 ug/ml." class="big_lightbox"> <img src="//images.novusbio.com/images/BRAF35-Antibody-1F6-Immunocytochemistry-Immunofluorescence-H00010362-M01-img0007.jpg" alt="Immunocytochemistry/Immunofluorescence: BRAF35 Antibody (1F6) [H00010362-M01] - Analysis of monoclonal antibody to HMG20B on HeLa cell. Antibody concentration 10 ug/ml." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/BRAF35-Antibody-1F6-Immunohistochemistry-Paraffin-H00010362-M01-img0009.jpg" title="Immunohistochemistry-Paraffin: BRAF35 Antibody (1F6) [H00010362-M01] - Analysis of monoclonal antibody to HMG20B on formalin-fixed paraffin-embedded human lung cancer. Antibody concentration 1.8 ug/ml." class="big_lightbox"> <img src="//images.novusbio.com/images/BRAF35-Antibody-1F6-Immunohistochemistry-Paraffin-H00010362-M01-img0009.jpg" alt="Immunohistochemistry-Paraffin: BRAF35 Antibody (1F6) [H00010362-M01] - Analysis of monoclonal antibody to HMG20B on formalin-fixed paraffin-embedded human lung cancer. Antibody concentration 1.8 ug/ml." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/BRAF35-Antibody-1F6-Western-Blot-H00010362-M01-img0001.jpg" title="Western Blot: BRAF35 Antibody (1F6) [H00010362-M01] - Western blot analysis of HMG20B in extracts from 293T, HeLa and A549 cell using anti-HMG20B monoclonal antibody ( Cat # L013V1 )." class="big_lightbox"> <img src="//images.novusbio.com/images/BRAF35-Antibody-1F6-Western-Blot-H00010362-M01-img0001.jpg" alt="Western Blot: BRAF35 Antibody (1F6) [H00010362-M01] - Western blot analysis of HMG20B in extracts from 293T, HeLa and A549 cell using anti-HMG20B monoclonal antibody ( Cat # L013V1 )." class="big_thumb" /> </a> </div><div class="big_thumb_container" style="visibility:hidden;"> <a href="//images.novusbio.com/fullsize/BRAF35-Antibody-1F6-Western-Blot-H00010362-M01-img0011.jpg" title="Western Blot: BRAF35 Antibody (1F6) [H00010362-M01] - Analysis of HMG20B in extracts from 293T, HeLa and A549 cell using anti-HMG20B monoclonal antibody." class="big_lightbox"> <img src="//images.novusbio.com/images/BRAF35-Antibody-1F6-Western-Blot-H00010362-M01-img0011.jpg" alt="Western Blot: BRAF35 Antibody (1F6) [H00010362-M01] - Analysis of HMG20B in extracts from 293T, HeLa and A549 cell using anti-HMG20B monoclonal antibody." class="big_thumb" /> </a> </div></div><div id="ss_next8" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-8" class="cycle-circle-pager"></div><div id="image-caption-H00010362-M01"></div> </div><div class="review_publication_wrapper forcol3"></div> <div class="product-attributes"><div class="field not3column"><label>Reactivity:</label><div class="value"><span title="Human">Hu</span><div class="myModal">Species Glossary</div></div></div><div class="forcol3 bottom_margin"><strong>Reactivity:</strong> <span title="Human">Hu</span></div><div class="field not3column"><label>Applications:</label><div class="value"><span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="ELISA">ELISA</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span></div></div><div class="forcol3 bottom_margin"><strong>Applications:</strong> <span class="application-tooltip-text" title="Western Blot">WB</span>, <span class="application-tooltip-text" title="ELISA">ELISA</span>, <span class="application-tooltip-text" title="Immunocytochemistry/ Immunofluorescence">ICC/IF</span>, <span class="application-tooltip-text" title="Immunohistochemistry">IHC</span></div><div class="field not3column"><label>Host:</label><div class="value">Mouse Monoclonal</div></div><div class="forcol3 bottom_margin"><strong>Host:</strong> Mouse Monoclonal</div><div class="field not3column"><label>Conjugate:</label><div class="value">Unconjugated  </div></div> </div> <div class="compare_block"><input type="checkbox" class="search_compare_checkbox" data-compare='{"Catalog #":"H00010362-M01","Product Name":"BRAF35 Antibody (1F6)","Description":"","Reactivity":"Human","Applications":"WB, ELISA, ICC\/IF, IHC","Source":"","Purification":"","Immunogen":"HMG20B (NP_006330, 1 a.a. ~ 109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MLGAEWSKLQPTEKQRYLDEAEREKQQYMKELRAYQQSEAYKMCTEKIQEKKIKKEDSSSGLMNTLLNGHKGGDCDGFSTFDVPIFTEEFLDQNKAREAELRRLRKMNV","Citations":"3","Purity":"IgG purified","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS Page":"","Assay Type":"","Format":"","Assay Length":"","Sample Type and Volume Required":"","Sensitivity":"","Interference":"","Datasheet":"<a href=\"\/products\/braf35-antibody-1f6_h00010362-m01\">view datasheet<\/a>","Price":"Price Not Shown"}'><div class="search_compare">compare</div> <div class="search_compare_text">(select up to 3 products from this page to compare)</div> </div> <div class="clear"></div> </div></div><div class="lower_framework"> <div class="search_pager"><div class="searchImage_backGrey" style="display:inline-block;zoom:1;width:6px;height:11px;background:url(//resources.rndsystems.com/images/search/searchSprite03-31-16.png) -18px -169px"></div> page <input type="text" value="1" class="search_pager_text" 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