CINXE.COM
Articles | BioData Mining
<!DOCTYPE html> <html lang="en" class="no-js"> <head> <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="applicable-device" content="pc,mobile"> <meta name="viewport" content="width=device-width, initial-scale=1"> <title>Articles | BioData Mining</title> <meta name="format-detection" content="telephone=no"> <link rel="apple-touch-icon" sizes="180x180" href=/static/img/favicons/bmc/apple-touch-icon-582ef1d0f5.png> <link rel="icon" type="image/png" sizes="192x192" href=/static/img/favicons/bmc/android-chrome-192x192-9625b7cdba.png> <link rel="icon" type="image/png" sizes="32x32" href=/static/img/favicons/bmc/favicon-32x32-5d7879efe1.png> <link rel="icon" type="image/png" sizes="16x16" href=/static/img/favicons/bmc/favicon-16x16-c241ac1a2f.png> <link rel="shortcut icon" data-test="shortcut-icon" href=/static/img/favicons/bmc/favicon-1886637b78.ico> <link rel="manifest" href=/static/app-bmc/manifest-3bb9ad383b.json> <meta name="msapplication-config" content=/static/app-bmc/browserconfig-ecd9aa8205.xml> <meta name="msapplication-TileColor" content="#1b3051"> <meta name="msapplication-TileImage" content=/static/img/favicons/bmc/app-icon-144x144.png> <meta name="theme-color" content="#1b3051"> <script>(function(H){H.className=H.className.replace(/\bno-js\b/,'js')})(document.documentElement)</script> <link rel="stylesheet" media="screen" href=/static/app-bmc/css/core-eac3097aa4.css> <link rel="stylesheet" media="print" href=/static/app-bmc/css/print-b8af42253b.css> <link rel="stylesheet" data-test="enhanced-stylesheet" href="/static/app-bmc/css/enhanced-32c9abc865.css" media="only print, only all and (prefers-color-scheme: no-preference), only all and (prefers-color-scheme: light), only all and (prefers-color-scheme: dark)"> <script type="text/javascript"> config = { env: 'live', site: 'biodatamining.biomedcentral.com', siteWithPath: 'biodatamining.biomedcentral.com' + window.location.pathname, twitterHashtag: '', cmsPrefix: 'https://studio-cms.springernature.com/studio/', figshareScriptUrl: 'https://widgets.figshare.com/static/figshare.js', hasFigshareInvoked: false, publisherBrand: 'BioMed Central', mustardcut: false }; </script> <script type="text/javascript" data-test="dataLayer"> window.dataLayer = [{"content":{"article":null,"contentInfo":{"imprint":"BioMed Central","title":null,"publishedAt":null,"publishedAtDate":null,"author":null,"collection":null},"attributes":{"deliveryPlatform":"oscar","template":"rebrand","cms":null,"copyright":null,"environment":"live"},"journal":{"siteKey":"biodatamining.biomedcentral.com","volume":null,"issue":null,"title":"BioData Mining","type":"BMC AJs","journalID":13040,"section":null},"category":{"pmc":{"primarySubject":"Life Sciences"},"contentType":null,"publishingSegment":"BMC AJ1","snt":["Computational and Systems Biology","Computational and Systems Biology","Data Mining and Knowledge Discovery","Bioinformatics","Algorithms"]}},"session":{"authentication":{"authenticationID":[]}},"version":"1.0.0","page":{"category":{"pageType":"other"},"attributes":{"featureFlags":[],"environment":"live","darwin":false}},"japan":false,"event":"dataLayerCreated","collection":null,"publisherBrand":"BioMed Central"}]; </script> <script> window.dataLayer = window.dataLayer || []; window.dataLayer.push({ ga4MeasurementId: 'G-PJCTJWPV25', ga360TrackingId: 'UA-54492316-9', twitterId: 'o47a2', baiduId: 'd1b4bc3b5ada4eb7290535e72899bac1', ga4ServerUrl: 'https://collect.biomedcentral.com', imprint: 'biomedcentral' }); </script> <script> (function(w, d) { w.config = w.config || {}; w.config.mustardcut = false; if (w.matchMedia && w.matchMedia('only print, only all and (prefers-color-scheme: no-preference), only all and (prefers-color-scheme: light), only all and (prefers-color-scheme: dark)').matches) { w.config.mustardcut = true; d.classList.add('js'); d.classList.remove('grade-c'); d.classList.remove('no-js'); } })(window, document.documentElement); </script> <script> (function () { if ( typeof window.CustomEvent === "function" ) return false; function CustomEvent ( event, params ) { params = params || { bubbles: false, cancelable: false, detail: null }; var evt = document.createEvent( 'CustomEvent' ); evt.initCustomEvent( event, params.bubbles, params.cancelable, params.detail ); return evt; } CustomEvent.prototype = window.Event.prototype; window.CustomEvent = CustomEvent; })(); </script> <script class="js-entry"> if (window.config.mustardcut) { (function(w, d) { var currentScript = d.currentScript || d.head.querySelector('script.js-entry'); function catchNoModuleSupport() { var scriptEl = d.createElement('script'); return (!('noModule' in scriptEl) && 'onbeforeload' in scriptEl) } var headScripts = [ {'src': '/static/js/polyfill-es5-bundle-572d4fec60.js', 'async': false} ]; var bodyScripts = [ {'src': '/static/js/app-es5-bundle-d0ac94c97e.js', 'async': false, 'module': false}, {'src': '/static/js/app-es6-bundle-5ee1a6879c.js', 'async': false, 'module': true} ]; function createScript(script) { var scriptEl = d.createElement('script'); scriptEl.src = script.src; scriptEl.async = script.async; if (script.module === true) { scriptEl.type = "module"; if (catchNoModuleSupport()) { scriptEl.src = ''; } } else if (script.module === false) { scriptEl.setAttribute('nomodule', true) } if (script.charset) { scriptEl.setAttribute('charset', script.charset); } return scriptEl; } for (var i = 0; i < headScripts.length; ++i) { var scriptEl = createScript(headScripts[i]); currentScript.parentNode.insertBefore(scriptEl, currentScript.nextSibling); } d.addEventListener('DOMContentLoaded', function() { for (var i = 0; i < bodyScripts.length; ++i) { var scriptEl = createScript(bodyScripts[i]); d.body.appendChild(scriptEl); } }); // Webfont repeat view var config = w.config; if (config && config.publisherBrand && sessionStorage.fontsLoaded === 'true') { d.documentElement.className += ' webfonts-loaded'; } })(window, document); } </script> <script data-test="gtm-head"> window.initGTM = function() { (function (w, d, s, l, i) { w[l] = w[l] || []; w[l].push({'gtm.start': new Date().getTime(), event: 'gtm.js'}); var f = d.getElementsByTagName(s)[0], j = d.createElement(s), dl = l != 'dataLayer' ? '&l=' + l : ''; j.async = true; j.src = 'https://www.googletagmanager.com/gtm.js?id=' + i + dl; f.parentNode.insertBefore(j, f); })(window, document, 'script', 'dataLayer', 'GTM-MRVXSHQ'); } </script> <meta name="360-site-verification" content="2e1d87196f82c9ac5454a21aede69eda" /> <script> (function (w, d, t) { function cc() { var h = w.location.hostname; var e = d.createElement(t), s = d.getElementsByTagName(t)[0]; if (h.indexOf('springer.com') > -1 && h.indexOf('biomedcentral.com') === -1 && h.indexOf('springeropen.com') === -1) { if (h.indexOf('link-qa.springer.com') > -1 || h.indexOf('test-www.springer.com') > -1) { e.src = 'https://cmp.springer.com/production_live/en/consent-bundle-17-52.js'; e.setAttribute('onload', "initGTM(window,document,'script','dataLayer','GTM-MRVXSHQ')"); } else { e.src = 'https://cmp.springer.com/production_live/en/consent-bundle-17-52.js'; e.setAttribute('onload', "initGTM(window,document,'script','dataLayer','GTM-MRVXSHQ')"); } } else if (h.indexOf('biomedcentral.com') > -1) { if (h.indexOf('biomedcentral.com.qa') > -1) { e.src = 'https://cmp.biomedcentral.com/production_live/en/consent-bundle-15-36.js'; e.setAttribute('onload', "initGTM(window,document,'script','dataLayer','GTM-MRVXSHQ')"); } else { e.src = 'https://cmp.biomedcentral.com/production_live/en/consent-bundle-15-36.js'; e.setAttribute('onload', "initGTM(window,document,'script','dataLayer','GTM-MRVXSHQ')"); } } else if (h.indexOf('springeropen.com') > -1) { if (h.indexOf('springeropen.com.qa') > -1) { e.src = 'https://cmp.springernature.com/production_live/en/consent-bundle-16-34.js'; e.setAttribute('onload', "initGTM(window,document,'script','dataLayer','GTM-MRVXSHQ')"); } else { e.src = 'https://cmp.springernature.com/production_live/en/consent-bundle-16-34.js'; e.setAttribute('onload', "initGTM(window,document,'script','dataLayer','GTM-MRVXSHQ')"); } } else if (h.indexOf('springernature.com') > -1) { if (h.indexOf('beta-qa.springernature.com') > -1) { e.src = 'https://cmp.springernature.com/production_live/en/consent-bundle-49-43.js'; e.setAttribute('onload', "initGTM(window,document,'script','dataLayer','GTM-NK22KLS')"); } else { e.src = 'https://cmp.springernature.com/production_live/en/consent-bundle-49-43.js'; e.setAttribute('onload', "initGTM(window,document,'script','dataLayer','GTM-NK22KLS')"); } } else { e.src = '/static/js/cookie-consent-es5-bundle-cb57c2c98a.js'; e.setAttribute('data-consent', h); } s.insertAdjacentElement('afterend', e); } cc(); })(window, document, 'script'); </script> <link rel="canonical" href="https://biodatamining.biomedcentral.com/articles"/> <meta name="keywords" content="BioData Mining, Computer Appl. in Life Sciences, Computational Biology/Bioinformatics, Data Mining and Knowledge Discovery, Bioinformatics, Algorithms"/> <meta name="description" content="Publishing innovative data science and big data research, BioData Mining advances research on all aspects of data mining applied to high-dimensional ..."/> <meta property="og:url" content="https://biodatamining.biomedcentral.com/articles"/> <meta property="og:type" content="website"/> <meta property="og:site_name" content="BioMed Central"/> <meta property="og:title" content="BioData Mining"/> <meta property="og:description" content="Publishing innovative data science and big data research, BioData Mining advances research on all aspects of data mining applied to high-dimensional ..."/> <meta property="og:image" content="https://media.springernature.com/w110/springer-static/cover/journal/13040.jpg"/> <meta property="twitter:title" content="BioData Mining"/> <meta property="twitter:image:alt" content="BioData Mining Cover Image"/> <meta property="twitter:description" content="Publishing innovative data science and big data research, BioData Mining advances research on all aspects of data mining applied to high-dimensional ..."/> <meta property="twitter:image" content="https://media.springernature.com/w110/springer-static/cover/journal/13040.jpg"/> <meta name="twitter:card" content="summary_large_image"/> </head> <body class="journal" > <div class="ctm"></div> <!-- Google Tag Manager (noscript) --> <noscript> <iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MRVXSHQ" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript> <!-- End Google Tag Manager (noscript) --> <div class="u-visually-hidden" aria-hidden="true"> <?xml version="1.0" encoding="UTF-8"?><!DOCTYPE svg PUBLIC "-//W3C//DTD SVG 1.1//EN" "http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><defs><path id="a" d="M0 .74h56.72v55.24H0z"/></defs><symbol id="icon-access" viewBox="0 0 18 18"><path d="m14 8c.5522847 0 1 .44771525 1 1v7h2.5c.2761424 0 .5.2238576.5.5v1.5h-18v-1.5c0-.2761424.22385763-.5.5-.5h2.5v-7c0-.55228475.44771525-1 1-1s1 .44771525 1 1v6.9996556h8v-6.9996556c0-.55228475.4477153-1 1-1zm-8 0 2 1v5l-2 1zm6 0v7l-2-1v-5zm-2.42653766-7.59857636 7.03554716 4.92488299c.4162533.29137735.5174853.86502537.226108 1.28127873-.1721584.24594054-.4534847.39241464-.7536934.39241464h-14.16284822c-.50810197 0-.92-.41189803-.92-.92 0-.30020869.1464741-.58153499.39241464-.75369337l7.03554714-4.92488299c.34432015-.2410241.80260453-.2410241 1.14692468 0zm-.57346234 2.03988748-3.65526982 2.55868888h7.31053962z" fill-rule="evenodd"/></symbol><symbol id="icon-account" viewBox="0 0 18 18"><path d="m10.2379028 16.9048051c1.3083556-.2032362 2.5118471-.7235183 3.5294683-1.4798399-.8731327-2.5141501-2.0638925-3.935978-3.7673711-4.3188248v-1.27684611c1.1651924-.41183641 2-1.52307546 2-2.82929429 0-1.65685425-1.3431458-3-3-3-1.65685425 0-3 1.34314575-3 3 0 1.30621883.83480763 2.41745788 2 2.82929429v1.27684611c-1.70347856.3828468-2.89423845 1.8046747-3.76737114 4.3188248 1.01762123.7563216 2.22111275 1.2766037 3.52946833 1.4798399.40563808.0629726.81921174.0951949 1.23790281.0951949s.83226473-.0322223 1.2379028-.0951949zm4.3421782-2.1721994c1.4927655-1.4532925 2.419919-3.484675 2.419919-5.7326057 0-4.418278-3.581722-8-8-8s-8 3.581722-8 8c0 2.2479307.92715352 4.2793132 2.41991895 5.7326057.75688473-2.0164459 1.83949951-3.6071894 3.48926591-4.3218837-1.14534283-.70360829-1.90918486-1.96796271-1.90918486-3.410722 0-2.209139 1.790861-4 4-4s4 1.790861 4 4c0 1.44275929-.763842 2.70711371-1.9091849 3.410722 1.6497664.7146943 2.7323812 2.3054378 3.4892659 4.3218837zm-5.580081 3.2673943c-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9 4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9z" fill-rule="evenodd"/></symbol><symbol id="icon-alert" viewBox="0 0 18 18"><path d="m4 10h2.5c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-3.08578644l-1.12132034 1.1213203c-.18753638.1875364-.29289322.4418903-.29289322.7071068v.1715729h14v-.1715729c0-.2652165-.1053568-.5195704-.2928932-.7071068l-1.7071068-1.7071067v-3.4142136c0-2.76142375-2.2385763-5-5-5-2.76142375 0-5 2.23857625-5 5zm3 4c0 1.1045695.8954305 2 2 2s2-.8954305 2-2zm-5 0c-.55228475 0-1-.4477153-1-1v-.1715729c0-.530433.21071368-1.0391408.58578644-1.4142135l1.41421356-1.4142136v-3c0-3.3137085 2.6862915-6 6-6s6 2.6862915 6 6v3l1.4142136 1.4142136c.3750727.3750727.5857864.8837805.5857864 1.4142135v.1715729c0 .5522847-.4477153 1-1 1h-4c0 1.6568542-1.3431458 3-3 3-1.65685425 0-3-1.3431458-3-3z" fill-rule="evenodd"/></symbol><symbol id="icon-arrow-broad" viewBox="0 0 16 16"><path d="m6.10307866 2.97190702v7.69043288l2.44965196-2.44676915c.38776071-.38730439 1.0088052-.39493524 1.38498697-.01919617.38609051.38563612.38643641 1.01053024-.00013864 1.39665039l-4.12239817 4.11754683c-.38616704.3857126-1.01187344.3861062-1.39846576-.0000311l-4.12258206-4.11773056c-.38618426-.38572979-.39254614-1.00476697-.01636437-1.38050605.38609047-.38563611 1.01018509-.38751562 1.4012233.00306241l2.44985644 2.4469734v-8.67638639c0-.54139983.43698413-.98042709.98493125-.98159081l7.89910522-.0043627c.5451687 0 .9871152.44142642.9871152.98595351s-.4419465.98595351-.9871152.98595351z" fill-rule="evenodd" transform="matrix(-1 0 0 -1 14 15)"/></symbol><symbol id="icon-arrow-down" viewBox="0 0 16 16"><path d="m3.28337502 11.5302405 4.03074001 4.176208c.37758093.3912076.98937525.3916069 1.367372-.0000316l4.03091977-4.1763942c.3775978-.3912252.3838182-1.0190815.0160006-1.4001736-.3775061-.39113013-.9877245-.39303641-1.3700683.003106l-2.39538585 2.4818345v-11.6147896l-.00649339-.11662112c-.055753-.49733869-.46370161-.88337888-.95867408-.88337888-.49497246 0-.90292107.38604019-.95867408.88337888l-.00649338.11662112v11.6147896l-2.39518594-2.4816273c-.37913917-.39282218-.98637524-.40056175-1.35419292-.0194697-.37750607.3911302-.37784433 1.0249269.00013556 1.4165479z" fill-rule="evenodd"/></symbol><symbol id="icon-arrow-left" viewBox="0 0 16 16"><path d="m4.46975946 3.28337502-4.17620792 4.03074001c-.39120768.37758093-.39160691.98937525.0000316 1.367372l4.1763942 4.03091977c.39122514.3775978 1.01908149.3838182 1.40017357.0160006.39113012-.3775061.3930364-.9877245-.00310603-1.3700683l-2.48183446-2.39538585h11.61478958l.1166211-.00649339c.4973387-.055753.8833789-.46370161.8833789-.95867408 0-.49497246-.3860402-.90292107-.8833789-.95867408l-.1166211-.00649338h-11.61478958l2.4816273-2.39518594c.39282216-.37913917.40056173-.98637524.01946965-1.35419292-.39113012-.37750607-1.02492687-.37784433-1.41654791.00013556z" fill-rule="evenodd"/></symbol><symbol id="icon-arrow-right" viewBox="0 0 16 16"><path d="m11.5302405 12.716625 4.176208-4.03074003c.3912076-.37758093.3916069-.98937525-.0000316-1.367372l-4.1763942-4.03091981c-.3912252-.37759778-1.0190815-.38381821-1.4001736-.01600053-.39113013.37750607-.39303641.98772445.003106 1.37006824l2.4818345 2.39538588h-11.6147896l-.11662112.00649339c-.49733869.055753-.88337888.46370161-.88337888.95867408 0 .49497246.38604019.90292107.88337888.95867408l.11662112.00649338h11.6147896l-2.4816273 2.39518592c-.39282218.3791392-.40056175.9863753-.0194697 1.3541929.3911302.3775061 1.0249269.3778444 1.4165479-.0001355z" fill-rule="evenodd"/></symbol><symbol id="icon-arrow-sub" viewBox="0 0 16 16"><path d="m7.89692134 4.97190702v7.69043288l-2.44965196-2.4467692c-.38776071-.38730434-1.0088052-.39493519-1.38498697-.0191961-.38609047.3856361-.38643643 1.0105302.00013864 1.3966504l4.12239817 4.1175468c.38616704.3857126 1.01187344.3861062 1.39846576-.0000311l4.12258202-4.1177306c.3861843-.3857298.3925462-1.0047669.0163644-1.380506-.3860905-.38563612-1.0101851-.38751563-1.4012233.0030624l-2.44985643 2.4469734v-8.67638639c0-.54139983-.43698413-.98042709-.98493125-.98159081l-7.89910525-.0043627c-.54516866 0-.98711517.44142642-.98711517.98595351s.44194651.98595351.98711517.98595351z" fill-rule="evenodd"/></symbol><symbol id="icon-arrow-up" viewBox="0 0 16 16"><path d="m12.716625 4.46975946-4.03074003-4.17620792c-.37758093-.39120768-.98937525-.39160691-1.367372.0000316l-4.03091981 4.1763942c-.37759778.39122514-.38381821 1.01908149-.01600053 1.40017357.37750607.39113012.98772445.3930364 1.37006824-.00310603l2.39538588-2.48183446v11.61478958l.00649339.1166211c.055753.4973387.46370161.8833789.95867408.8833789.49497246 0 .90292107-.3860402.95867408-.8833789l.00649338-.1166211v-11.61478958l2.39518592 2.4816273c.3791392.39282216.9863753.40056173 1.3541929.01946965.3775061-.39113012.3778444-1.02492687-.0001355-1.41654791z" fill-rule="evenodd"/></symbol><symbol id="icon-article" viewBox="0 0 18 18"><path d="m13 15v-12.9906311c0-.0073595-.0019884-.0093689.0014977-.0093689l-11.00158888.00087166v13.00506804c0 .5482678.44615281.9940603.99415146.9940603h10.27350412c-.1701701-.2941734-.2675644-.6357129-.2675644-1zm-12 .0059397v-13.00506804c0-.5562408.44704472-1.00087166.99850233-1.00087166h11.00299537c.5510129 0 .9985023.45190985.9985023 1.0093689v2.9906311h3v9.9914698c0 1.1065798-.8927712 2.0085302-1.9940603 2.0085302h-12.01187942c-1.09954652 0-1.99406028-.8927712-1.99406028-1.9940603zm13-9.0059397v9c0 .5522847.4477153 1 1 1s1-.4477153 1-1v-9zm-10-2h7v4h-7zm1 1v2h5v-2zm-1 4h7v1h-7zm0 2h7v1h-7zm0 2h7v1h-7z" fill-rule="evenodd"/></symbol><symbol id="icon-audio" viewBox="0 0 18 18"><path d="m13.0957477 13.5588459c-.195279.1937043-.5119137.193729-.7072234.0000551-.1953098-.193674-.1953346-.5077061-.0000556-.7014104 1.0251004-1.0168342 1.6108711-2.3905226 1.6108711-3.85745208 0-1.46604976-.5850634-2.83898246-1.6090736-3.85566829-.1951894-.19379323-.1950192-.50782531.0003802-.70141028.1953993-.19358497.512034-.19341614.7072234.00037709 1.2094886 1.20083761 1.901635 2.8250555 1.901635 4.55670148 0 1.73268608-.6929822 3.35779608-1.9037571 4.55880738zm2.1233994 2.1025159c-.195234.193749-.5118687.1938462-.7072235.0002171-.1953548-.1936292-.1954528-.5076613-.0002189-.7014104 1.5832215-1.5711805 2.4881302-3.6939808 2.4881302-5.96012998 0-2.26581266-.9046382-4.3883241-2.487443-5.95944795-.1952117-.19377107-.1950777-.50780316.0002993-.70141031s.5120117-.19347426.7072234.00029682c1.7683321 1.75528196 2.7800854 4.12911258 2.7800854 6.66056144 0 2.53182498-1.0120556 4.90597838-2.7808529 6.66132328zm-14.21898205-3.6854911c-.5523759 0-1.00016505-.4441085-1.00016505-.991944v-3.96777631c0-.54783558.44778915-.99194407 1.00016505-.99194407h2.0003301l5.41965617-3.8393633c.44948677-.31842296 1.07413994-.21516983 1.39520191.23062232.12116339.16823446.18629727.36981184.18629727.57655577v12.01603479c0 .5478356-.44778914.9919441-1.00016505.9919441-.20845738 0-.41170538-.0645985-.58133413-.184766l-5.41965617-3.8393633zm0-.991944h2.32084805l5.68047235 4.0241292v-12.01603479l-5.68047235 4.02412928h-2.32084805z" fill-rule="evenodd"/></symbol><symbol id="icon-block" viewBox="0 0 24 24"><path d="m0 0h24v24h-24z" fill-rule="evenodd"/></symbol><symbol id="icon-book" viewBox="0 0 18 18"><path d="m4 13v-11h1v11h11v-11h-13c-.55228475 0-1 .44771525-1 1v10.2675644c.29417337-.1701701.63571286-.2675644 1-.2675644zm12 1h-13c-.55228475 0-1 .4477153-1 1s.44771525 1 1 1h13zm0 3h-13c-1.1045695 0-2-.8954305-2-2v-12c0-1.1045695.8954305-2 2-2h13c.5522847 0 1 .44771525 1 1v14c0 .5522847-.4477153 1-1 1zm-8.5-13h6c.2761424 0 .5.22385763.5.5s-.2238576.5-.5.5h-6c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5zm1 2h4c.2761424 0 .5.22385763.5.5s-.2238576.5-.5.5h-4c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5z" fill-rule="evenodd"/></symbol><symbol id="icon-broad" viewBox="0 0 24 24"><path d="m9.18274226 7.81v7.7999954l2.48162734-2.4816273c.3928221-.3928221 1.0219731-.4005617 1.4030652-.0194696.3911301.3911301.3914806 1.0249268-.0001404 1.4165479l-4.17620796 4.1762079c-.39120769.3912077-1.02508144.3916069-1.41671995-.0000316l-4.1763942-4.1763942c-.39122514-.3912251-.39767006-1.0190815-.01657798-1.4001736.39113012-.3911301 1.02337106-.3930364 1.41951349.0031061l2.48183446 2.4818344v-8.7999954c0-.54911294.4426881-.99439484.99778758-.99557515l8.00221246-.00442485c.5522847 0 1 .44771525 1 1s-.4477153 1-1 1z" fill-rule="evenodd" transform="matrix(-1 0 0 -1 20.182742 24.805206)"/></symbol><symbol id="icon-calendar" viewBox="0 0 18 18"><path d="m12.5 0c.2761424 0 .5.21505737.5.49047852v.50952148h2c1.1072288 0 2 .89451376 2 2v12c0 1.1072288-.8945138 2-2 2h-12c-1.1072288 0-2-.8945138-2-2v-12c0-1.1072288.89451376-2 2-2h1v1h-1c-.55393837 0-1 .44579254-1 1v3h14v-3c0-.55393837-.4457925-1-1-1h-2v1.50952148c0 .27088381-.2319336.49047852-.5.49047852-.2761424 0-.5-.21505737-.5-.49047852v-3.01904296c0-.27088381.2319336-.49047852.5-.49047852zm3.5 7h-14v8c0 .5539384.44579254 1 1 1h12c.5539384 0 1-.4457925 1-1zm-11 6v1h-1v-1zm3 0v1h-1v-1zm3 0v1h-1v-1zm-6-2v1h-1v-1zm3 0v1h-1v-1zm6 0v1h-1v-1zm-3 0v1h-1v-1zm-3-2v1h-1v-1zm6 0v1h-1v-1zm-3 0v1h-1v-1zm-5.5-9c.27614237 0 .5.21505737.5.49047852v.50952148h5v1h-5v1.50952148c0 .27088381-.23193359.49047852-.5.49047852-.27614237 0-.5-.21505737-.5-.49047852v-3.01904296c0-.27088381.23193359-.49047852.5-.49047852z" fill-rule="evenodd"/></symbol><symbol id="icon-cart" viewBox="0 0 18 18"><path d="m5 14c1.1045695 0 2 .8954305 2 2s-.8954305 2-2 2-2-.8954305-2-2 .8954305-2 2-2zm10 0c1.1045695 0 2 .8954305 2 2s-.8954305 2-2 2-2-.8954305-2-2 .8954305-2 2-2zm-10 1c-.55228475 0-1 .4477153-1 1s.44771525 1 1 1 1-.4477153 1-1-.44771525-1-1-1zm10 0c-.5522847 0-1 .4477153-1 1s.4477153 1 1 1 1-.4477153 1-1-.4477153-1-1-1zm-12.82032249-15c.47691417 0 .88746157.33678127.98070211.80449199l.23823144 1.19501025 13.36277974.00045554c.5522847.00001882.9999659.44774934.9999659 1.00004222 0 .07084994-.0075361.14150708-.022474.2107727l-1.2908094 5.98534344c-.1007861.46742419-.5432548.80388386-1.0571651.80388386h-10.24805106c-.59173366 0-1.07142857.4477153-1.07142857 1 0 .5128358.41361449.9355072.94647737.9932723l.1249512.0067277h10.35933776c.2749512 0 .4979349.2228539.4979349.4978051 0 .2749417-.2227336.4978951-.4976753.4980063l-10.35959736.0041886c-1.18346732 0-2.14285714-.8954305-2.14285714-2 0-.6625717.34520317-1.24989198.87690425-1.61383592l-1.63768102-8.19004794c-.01312273-.06561364-.01950005-.131011-.0196107-.19547395l-1.71961253-.00064219c-.27614237 0-.5-.22385762-.5-.5 0-.27614237.22385763-.5.5-.5zm14.53193359 2.99950224h-13.11300004l1.20580469 6.02530174c.11024034-.0163252.22327998-.02480398.33844139-.02480398h10.27064786z"/></symbol><symbol id="icon-chevron-less" viewBox="0 0 10 10"><path d="m5.58578644 4-3.29289322-3.29289322c-.39052429-.39052429-.39052429-1.02368927 0-1.41421356s1.02368927-.39052429 1.41421356 0l4 4c.39052429.39052429.39052429 1.02368927 0 1.41421356l-4 4c-.39052429.39052429-1.02368927.39052429-1.41421356 0s-.39052429-1.02368927 0-1.41421356z" fill-rule="evenodd" transform="matrix(0 -1 -1 0 9 9)"/></symbol><symbol id="icon-chevron-more" viewBox="0 0 10 10"><path d="m5.58578644 6-3.29289322-3.29289322c-.39052429-.39052429-.39052429-1.02368927 0-1.41421356s1.02368927-.39052429 1.41421356 0l4 4c.39052429.39052429.39052429 1.02368927 0 1.41421356l-4 4.00000002c-.39052429.3905243-1.02368927.3905243-1.41421356 0s-.39052429-1.02368929 0-1.41421358z" fill-rule="evenodd" transform="matrix(0 1 -1 0 11 1)"/></symbol><symbol id="icon-chevron-right" viewBox="0 0 10 10"><path d="m5.96738168 4.70639573 2.39518594-2.41447274c.37913917-.38219212.98637524-.38972225 1.35419292-.01894278.37750606.38054586.37784436.99719163-.00013556 1.37821513l-4.03074001 4.06319683c-.37758093.38062133-.98937525.38100976-1.367372-.00003075l-4.03091981-4.06337806c-.37759778-.38063832-.38381821-.99150444-.01600053-1.3622839.37750607-.38054587.98772445-.38240057 1.37006824.00302197l2.39538588 2.4146743.96295325.98624457z" fill-rule="evenodd" transform="matrix(0 -1 1 0 0 10)"/></symbol><symbol id="icon-circle-fill" viewBox="0 0 16 16"><path d="m8 14c-3.3137085 0-6-2.6862915-6-6s2.6862915-6 6-6 6 2.6862915 6 6-2.6862915 6-6 6z" fill-rule="evenodd"/></symbol><symbol id="icon-circle" viewBox="0 0 16 16"><path d="m8 12c2.209139 0 4-1.790861 4-4s-1.790861-4-4-4-4 1.790861-4 4 1.790861 4 4 4zm0 2c-3.3137085 0-6-2.6862915-6-6s2.6862915-6 6-6 6 2.6862915 6 6-2.6862915 6-6 6z" fill-rule="evenodd"/></symbol><symbol id="icon-citation" viewBox="0 0 18 18"><path d="m8.63593473 5.99995183c2.20913897 0 3.99999997 1.79084375 3.99999997 3.99996146 0 1.40730761-.7267788 2.64486871-1.8254829 3.35783281 1.6240224.6764218 2.8754442 2.0093871 3.4610603 3.6412466l-1.0763845.000006c-.5310008-1.2078237-1.5108121-2.1940153-2.7691712-2.7181346l-.79002167-.329052v-1.023992l.63016577-.4089232c.8482885-.5504661 1.3698342-1.4895187 1.3698342-2.51898361 0-1.65683828-1.3431457-2.99996146-2.99999997-2.99996146-1.65685425 0-3 1.34312318-3 2.99996146 0 1.02946491.52154569 1.96851751 1.36983419 2.51898361l.63016581.4089232v1.023992l-.79002171.329052c-1.25835905.5241193-2.23817037 1.5103109-2.76917113 2.7181346l-1.07638453-.000006c.58561612-1.6318595 1.8370379-2.9648248 3.46106024-3.6412466-1.09870405-.7129641-1.82548287-1.9505252-1.82548287-3.35783281 0-2.20911771 1.790861-3.99996146 4-3.99996146zm7.36897597-4.99995183c1.1018574 0 1.9950893.89353404 1.9950893 2.00274083v5.994422c0 1.10608317-.8926228 2.00274087-1.9950893 2.00274087l-3.0049107-.0009037v-1l3.0049107.00091329c.5490631 0 .9950893-.44783123.9950893-1.00275046v-5.994422c0-.55646537-.4450595-1.00275046-.9950893-1.00275046h-14.00982141c-.54906309 0-.99508929.44783123-.99508929 1.00275046v5.9971821c0 .66666024.33333333.99999036 1 .99999036l2-.00091329v1l-2 .0009037c-1 0-2-.99999041-2-1.99998077v-5.9971821c0-1.10608322.8926228-2.00274083 1.99508929-2.00274083zm-8.5049107 2.9999711c.27614237 0 .5.22385547.5.5 0 .2761349-.22385763.5-.5.5h-4c-.27614237 0-.5-.2238651-.5-.5 0-.27614453.22385763-.5.5-.5zm3 0c.2761424 0 .5.22385547.5.5 0 .2761349-.2238576.5-.5.5h-1c-.27614237 0-.5-.2238651-.5-.5 0-.27614453.22385763-.5.5-.5zm4 0c.2761424 0 .5.22385547.5.5 0 .2761349-.2238576.5-.5.5h-2c-.2761424 0-.5-.2238651-.5-.5 0-.27614453.2238576-.5.5-.5z" fill-rule="evenodd"/></symbol><symbol id="icon-close" viewBox="0 0 16 16"><path d="m2.29679575 12.2772478c-.39658757.3965876-.39438847 1.0328109-.00062148 1.4265779.39651227.3965123 1.03246768.3934888 1.42657791-.0006214l4.27724782-4.27724787 4.2772478 4.27724787c.3965876.3965875 1.0328109.3943884 1.4265779.0006214.3965123-.3965122.3934888-1.0324677-.0006214-1.4265779l-4.27724787-4.2772478 4.27724787-4.27724782c.3965875-.39658757.3943884-1.03281091.0006214-1.42657791-.3965122-.39651226-1.0324677-.39348875-1.4265779.00062148l-4.2772478 4.27724782-4.27724782-4.27724782c-.39658757-.39658757-1.03281091-.39438847-1.42657791-.00062148-.39651226.39651227-.39348875 1.03246768.00062148 1.42657791l4.27724782 4.27724782z" fill-rule="evenodd"/></symbol><symbol id="icon-collections" viewBox="0 0 18 18"><path d="m15 4c1.1045695 0 2 .8954305 2 2v9c0 1.1045695-.8954305 2-2 2h-8c-1.1045695 0-2-.8954305-2-2h1c0 .5128358.38604019.9355072.88337887.9932723l.11662113.0067277h8c.5128358 0 .9355072-.3860402.9932723-.8833789l.0067277-.1166211v-9c0-.51283584-.3860402-.93550716-.8833789-.99327227l-.1166211-.00672773h-1v-1zm-4-3c1.1045695 0 2 .8954305 2 2v9c0 1.1045695-.8954305 2-2 2h-8c-1.1045695 0-2-.8954305-2-2v-9c0-1.1045695.8954305-2 2-2zm0 1h-8c-.51283584 0-.93550716.38604019-.99327227.88337887l-.00672773.11662113v9c0 .5128358.38604019.9355072.88337887.9932723l.11662113.0067277h8c.5128358 0 .9355072-.3860402.9932723-.8833789l.0067277-.1166211v-9c0-.51283584-.3860402-.93550716-.8833789-.99327227zm-1.5 7c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-5c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5zm0-2c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-5c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5zm0-2c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-5c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5z" fill-rule="evenodd"/></symbol><symbol id="icon-compare" viewBox="0 0 18 18"><path d="m12 3c3.3137085 0 6 2.6862915 6 6s-2.6862915 6-6 6c-1.0928452 0-2.11744941-.2921742-2.99996061-.8026704-.88181407.5102749-1.90678042.8026704-3.00003939.8026704-3.3137085 0-6-2.6862915-6-6s2.6862915-6 6-6c1.09325897 0 2.11822532.29239547 3.00096303.80325037.88158756-.51107621 1.90619177-.80325037 2.99903697-.80325037zm-6 1c-2.76142375 0-5 2.23857625-5 5 0 2.7614237 2.23857625 5 5 5 .74397391 0 1.44999672-.162488 2.08451611-.4539116-1.27652344-1.1000812-2.08451611-2.7287264-2.08451611-4.5460884s.80799267-3.44600721 2.08434391-4.5463015c-.63434719-.29121054-1.34037-.4536985-2.08434391-.4536985zm6 0c-.7439739 0-1.4499967.16248796-2.08451611.45391156 1.27652341 1.10008123 2.08451611 2.72872644 2.08451611 4.54608844s-.8079927 3.4460072-2.08434391 4.5463015c.63434721.2912105 1.34037001.4536985 2.08434391.4536985 2.7614237 0 5-2.2385763 5-5 0-2.76142375-2.2385763-5-5-5zm-1.4162763 7.0005324h-3.16744736c.15614659.3572676.35283837.6927622.58425872 1.0006671h1.99892988c.23142036-.3079049.42811216-.6433995.58425876-1.0006671zm.4162763-2.0005324h-4c0 .34288501.0345146.67770871.10025909 1.0011864h3.79948181c.0657445-.32347769.1002591-.65830139.1002591-1.0011864zm-.4158423-1.99953894h-3.16831543c-.13859957.31730812-.24521946.651783-.31578599.99935097h3.79988742c-.0705665-.34756797-.1771864-.68204285-.315786-.99935097zm-1.58295822-1.999926-.08316107.06199199c-.34550042.27081213-.65446126.58611297-.91825862.93727862h2.00044041c-.28418626-.37830727-.6207872-.71499149-.99902072-.99927061z" fill-rule="evenodd"/></symbol><symbol id="icon-download-file" viewBox="0 0 18 18"><path d="m10.0046024 0c.5497429 0 1.3179837.32258606 1.707238.71184039l4.5763192 4.57631922c.3931386.39313859.7118404 1.16760135.7118404 1.71431368v8.98899651c0 1.1092806-.8945138 2.0085302-1.9940603 2.0085302h-12.01187942c-1.10128908 0-1.99406028-.8926228-1.99406028-1.9950893v-14.00982141c0-1.10185739.88743329-1.99508929 1.99961498-1.99508929zm0 1h-7.00498742c-.55709576 0-.99961498.44271433-.99961498.99508929v14.00982141c0 .5500396.44491393.9950893.99406028.9950893h12.01187942c.5463747 0 .9940603-.4506622.9940603-1.0085302v-8.98899651c0-.28393444-.2150684-.80332809-.4189472-1.0072069l-4.5763192-4.57631922c-.2038461-.20384606-.718603-.41894717-1.0001312-.41894717zm-1.5046024 4c.27614237 0 .5.21637201.5.49209595v6.14827645l1.7462789-1.77990922c.1933927-.1971171.5125222-.19455839.7001689-.0069117.1932998.19329992.1910058.50899492-.0027774.70277812l-2.59089271 2.5908927c-.19483374.1948337-.51177825.1937771-.70556873-.0000133l-2.59099079-2.5909908c-.19484111-.1948411-.19043735-.5151448-.00279066-.70279146.19329987-.19329987.50465175-.19237083.70018565.00692852l1.74638684 1.78001764v-6.14827695c0-.27177709.23193359-.49209595.5-.49209595z" fill-rule="evenodd"/></symbol><symbol id="icon-download" viewBox="0 0 16 16"><path d="m12.9975267 12.999368c.5467123 0 1.0024733.4478567 1.0024733 1.000316 0 .5563109-.4488226 1.000316-1.0024733 1.000316h-9.99505341c-.54671233 0-1.00247329-.4478567-1.00247329-1.000316 0-.5563109.44882258-1.000316 1.00247329-1.000316zm-4.9975267-11.999368c.55228475 0 1 .44497754 1 .99589209v6.80214418l2.4816273-2.48241149c.3928222-.39294628 1.0219732-.4006883 1.4030652-.01947579.3911302.39125371.3914806 1.02525073-.0001404 1.41699553l-4.17620792 4.17752758c-.39120769.3913313-1.02508144.3917306-1.41671995-.0000316l-4.17639421-4.17771394c-.39122513-.39134876-.39767006-1.01940351-.01657797-1.40061601.39113012-.39125372 1.02337105-.3931606 1.41951349.00310701l2.48183446 2.48261871v-6.80214418c0-.55001601.44386482-.99589209 1-.99589209z" fill-rule="evenodd"/></symbol><symbol id="icon-editors" viewBox="0 0 18 18"><path d="m8.72592184 2.54588137c-.48811714-.34391207-1.08343326-.54588137-1.72592184-.54588137-1.65685425 0-3 1.34314575-3 3 0 1.02947485.5215457 1.96853646 1.3698342 2.51900785l.6301658.40892721v1.02400182l-.79002171.32905522c-1.93395773.8055207-3.20997829 2.7024791-3.20997829 4.8180274v.9009805h-1v-.9009805c0-2.5479714 1.54557359-4.79153984 3.82548288-5.7411543-1.09870406-.71297106-1.82548288-1.95054399-1.82548288-3.3578652 0-2.209139 1.790861-4 4-4 1.09079823 0 2.07961816.43662103 2.80122451 1.1446278-.37707584.09278571-.7373238.22835063-1.07530267.40125357zm-2.72592184 14.45411863h-1v-.9009805c0-2.5479714 1.54557359-4.7915398 3.82548288-5.7411543-1.09870406-.71297106-1.82548288-1.95054399-1.82548288-3.3578652 0-2.209139 1.790861-4 4-4s4 1.790861 4 4c0 1.40732121-.7267788 2.64489414-1.8254829 3.3578652 2.2799093.9496145 3.8254829 3.1931829 3.8254829 5.7411543v.9009805h-1v-.9009805c0-2.1155483-1.2760206-4.0125067-3.2099783-4.8180274l-.7900217-.3290552v-1.02400184l.6301658-.40892721c.8482885-.55047139 1.3698342-1.489533 1.3698342-2.51900785 0-1.65685425-1.3431458-3-3-3-1.65685425 0-3 1.34314575-3 3 0 1.02947485.5215457 1.96853646 1.3698342 2.51900785l.6301658.40892721v1.02400184l-.79002171.3290552c-1.93395773.8055207-3.20997829 2.7024791-3.20997829 4.8180274z" fill-rule="evenodd"/></symbol><symbol id="icon-email" viewBox="0 0 18 18"><path d="m16.0049107 2c1.1018574 0 1.9950893.89706013 1.9950893 2.00585866v9.98828264c0 1.1078052-.8926228 2.0058587-1.9950893 2.0058587h-14.00982141c-1.10185739 0-1.99508929-.8970601-1.99508929-2.0058587v-9.98828264c0-1.10780515.8926228-2.00585866 1.99508929-2.00585866zm0 1h-14.00982141c-.54871518 0-.99508929.44887827-.99508929 1.00585866v9.98828264c0 .5572961.44630695 1.0058587.99508929 1.0058587h14.00982141c.5487152 0 .9950893-.4488783.9950893-1.0058587v-9.98828264c0-.55729607-.446307-1.00585866-.9950893-1.00585866zm-.0049107 2.55749512v1.44250488l-7 4-7-4v-1.44250488l7 4z" fill-rule="evenodd"/></symbol><symbol id="icon-error" viewBox="0 0 18 18"><path d="m9 0c4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9zm2.8630343 4.71100931-2.8630343 2.86303426-2.86303426-2.86303426c-.39658757-.39658757-1.03281091-.39438847-1.4265779-.00062147-.39651227.39651226-.39348876 1.03246767.00062147 1.4265779l2.86303426 2.86303426-2.86303426 2.8630343c-.39658757.3965875-.39438847 1.0328109-.00062147 1.4265779.39651226.3965122 1.03246767.3934887 1.4265779-.0006215l2.86303426-2.8630343 2.8630343 2.8630343c.3965875.3965876 1.0328109.3943885 1.4265779.0006215.3965122-.3965123.3934887-1.0324677-.0006215-1.4265779l-2.8630343-2.8630343 2.8630343-2.86303426c.3965876-.39658757.3943885-1.03281091.0006215-1.4265779-.3965123-.39651227-1.0324677-.39348876-1.4265779.00062147z" fill-rule="evenodd"/></symbol><symbol id="icon-ethics" viewBox="0 0 18 18"><path d="m6.76384967 1.41421356.83301651-.8330165c.77492941-.77492941 2.03133823-.77492941 2.80626762 0l.8330165.8330165c.3750728.37507276.8837806.58578644 1.4142136.58578644h1.3496361c1.1045695 0 2 .8954305 2 2v1.34963611c0 .53043298.2107137 1.03914081.5857864 1.41421356l.8330165.83301651c.7749295.77492941.7749295 2.03133823 0 2.80626762l-.8330165.8330165c-.3750727.3750728-.5857864.8837806-.5857864 1.4142136v1.3496361c0 1.1045695-.8954305 2-2 2h-1.3496361c-.530433 0-1.0391408.2107137-1.4142136.5857864l-.8330165.8330165c-.77492939.7749295-2.03133821.7749295-2.80626762 0l-.83301651-.8330165c-.37507275-.3750727-.88378058-.5857864-1.41421356-.5857864h-1.34963611c-1.1045695 0-2-.8954305-2-2v-1.3496361c0-.530433-.21071368-1.0391408-.58578644-1.4142136l-.8330165-.8330165c-.77492941-.77492939-.77492941-2.03133821 0-2.80626762l.8330165-.83301651c.37507276-.37507275.58578644-.88378058.58578644-1.41421356v-1.34963611c0-1.1045695.8954305-2 2-2h1.34963611c.53043298 0 1.03914081-.21071368 1.41421356-.58578644zm-1.41421356 1.58578644h-1.34963611c-.55228475 0-1 .44771525-1 1v1.34963611c0 .79564947-.31607052 1.55871121-.87867966 2.12132034l-.8330165.83301651c-.38440512.38440512-.38440512 1.00764896 0 1.39205408l.8330165.83301646c.56260914.5626092.87867966 1.3256709.87867966 2.1213204v1.3496361c0 .5522847.44771525 1 1 1h1.34963611c.79564947 0 1.55871121.3160705 2.12132034.8786797l.83301651.8330165c.38440512.3844051 1.00764896.3844051 1.39205408 0l.83301646-.8330165c.5626092-.5626092 1.3256709-.8786797 2.1213204-.8786797h1.3496361c.5522847 0 1-.4477153 1-1v-1.3496361c0-.7956495.3160705-1.5587112.8786797-2.1213204l.8330165-.83301646c.3844051-.38440512.3844051-1.00764896 0-1.39205408l-.8330165-.83301651c-.5626092-.56260913-.8786797-1.32567087-.8786797-2.12132034v-1.34963611c0-.55228475-.4477153-1-1-1h-1.3496361c-.7956495 0-1.5587112-.31607052-2.1213204-.87867966l-.83301646-.8330165c-.38440512-.38440512-1.00764896-.38440512-1.39205408 0l-.83301651.8330165c-.56260913.56260914-1.32567087.87867966-2.12132034.87867966zm3.58698944 11.4960218c-.02081224.002155-.04199226.0030286-.06345763.002542-.98766446-.0223875-1.93408568-.3063547-2.75885125-.8155622-.23496767-.1450683-.30784554-.4531483-.16277726-.688116.14506827-.2349677.45314827-.3078455.68811595-.1627773.67447084.4164161 1.44758575.6483839 2.25617384.6667123.01759529.0003988.03495764.0017019.05204365.0038639.01713363-.0017748.03452416-.0026845.05212715-.0026845 2.4852814 0 4.5-2.0147186 4.5-4.5 0-1.04888973-.3593547-2.04134635-1.0074477-2.83787157-.1742817-.21419731-.1419238-.5291218.0722736-.70340353.2141973-.17428173.5291218-.14192375.7034035.07227357.7919032.97327203 1.2317706 2.18808682 1.2317706 3.46900153 0 3.0375661-2.4624339 5.5-5.5 5.5-.02146768 0-.04261937-.0013529-.06337445-.0039782zm1.57975095-10.78419583c.2654788.07599731.419084.35281842.3430867.61829728-.0759973.26547885-.3528185.419084-.6182973.3430867-.37560116-.10752146-.76586237-.16587951-1.15568824-.17249193-2.5587807-.00064534-4.58547766 2.00216524-4.58547766 4.49928198 0 .62691557.12797645 1.23496.37274865 1.7964426.11035133.2531347-.0053975.5477984-.25853224.6581497-.25313473.1103514-.54779841-.0053975-.65814974-.2585322-.29947131-.6869568-.45606667-1.43097603-.45606667-2.1960601 0-3.05211432 2.47714695-5.50006595 5.59399617-5.49921198.48576182.00815502.96289603.0795037 1.42238033.21103795zm-1.9766658 6.41091303 2.69835-2.94655317c.1788432-.21040373.4943901-.23598862.7047939-.05714545.2104037.17884318.2359886.49439014.0571454.70479387l-3.01637681 3.34277395c-.18039088.1999106-.48669547.2210637-.69285412.0478478l-1.93095347-1.62240047c-.21213845-.17678204-.24080048-.49206439-.06401844-.70420284.17678204-.21213844.49206439-.24080048.70420284-.06401844z" fill-rule="evenodd"/></symbol><symbol id="icon-expand"><path d="M7.498 11.918a.997.997 0 0 0-.003-1.411.995.995 0 0 0-1.412-.003l-4.102 4.102v-3.51A1 1 0 0 0 .98 10.09.992.992 0 0 0 0 11.092V17c0 .554.448 1.002 1.002 1.002h5.907c.554 0 1.002-.45 1.002-1.003 0-.539-.45-.978-1.006-.978h-3.51zm3.005-5.835a.997.997 0 0 0 .003 1.412.995.995 0 0 0 1.411.003l4.103-4.103v3.51a1 1 0 0 0 1.001 1.006A.992.992 0 0 0 18 6.91V1.002A1 1 0 0 0 17 0h-5.907a1.003 1.003 0 0 0-1.002 1.003c0 .539.45.978 1.006.978h3.51z" fill-rule="evenodd"/></symbol><symbol id="icon-explore" viewBox="0 0 18 18"><path d="m9 17c4.418278 0 8-3.581722 8-8s-3.581722-8-8-8-8 3.581722-8 8 3.581722 8 8 8zm0 1c-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9 4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9zm0-2.5c-.27614237 0-.5-.2238576-.5-.5s.22385763-.5.5-.5c2.969509 0 5.400504-2.3575119 5.497023-5.31714844.0090007-.27599565.2400359-.49243782.5160315-.48343711.2759957.0090007.4924378.2400359.4834371.51603155-.114093 3.4985237-2.9869632 6.284554-6.4964916 6.284554zm-.29090657-12.99359748c.27587424-.01216621.50937715.20161139.52154336.47748563.01216621.27587423-.20161139.50937715-.47748563.52154336-2.93195733.12930094-5.25315116 2.54886451-5.25315116 5.49456849 0 .27614237-.22385763.5-.5.5s-.5-.22385763-.5-.5c0-3.48142406 2.74307146-6.34074398 6.20909343-6.49359748zm1.13784138 8.04763908-1.2004882-1.20048821c-.19526215-.19526215-.19526215-.51184463 0-.70710678s.51184463-.19526215.70710678 0l1.20048821 1.2004882 1.6006509-4.00162734-4.50670359 1.80268144-1.80268144 4.50670359zm4.10281269-6.50378907-2.6692597 6.67314927c-.1016411.2541026-.3029834.4554449-.557086.557086l-6.67314927 2.6692597 2.66925969-6.67314926c.10164107-.25410266.30298336-.45544495.55708602-.55708602z" fill-rule="evenodd"/></symbol><symbol id="icon-filter" viewBox="0 0 16 16"><path d="m14.9738641 0c.5667192 0 1.0261359.4477136 1.0261359 1 0 .24221858-.0902161.47620768-.2538899.65849851l-5.6938314 6.34147206v5.49997973c0 .3147562-.1520673.6111434-.4104543.7999971l-2.05227171 1.4999945c-.45337535.3313696-1.09655869.2418269-1.4365902-.1999993-.13321514-.1730955-.20522717-.3836284-.20522717-.5999978v-6.99997423l-5.69383133-6.34147206c-.3731872-.41563511-.32996891-1.0473954.09653074-1.41107611.18705584-.15950448.42716133-.2474224.67571519-.2474224zm-5.9218641 8.5h-2.105v6.491l.01238459.0070843.02053271.0015705.01955278-.0070558 2.0532976-1.4990996zm-8.02585008-7.5-.01564945.00240169 5.83249953 6.49759831h2.313l5.836-6.499z"/></symbol><symbol id="icon-home" viewBox="0 0 18 18"><path d="m9 5-6 6v5h4v-4h4v4h4v-5zm7 6.5857864v4.4142136c0 .5522847-.4477153 1-1 1h-5v-4h-2v4h-5c-.55228475 0-1-.4477153-1-1v-4.4142136c-.25592232 0-.51184464-.097631-.70710678-.2928932l-.58578644-.5857864c-.39052429-.3905243-.39052429-1.02368929 0-1.41421358l8.29289322-8.29289322 8.2928932 8.29289322c.3905243.39052429.3905243 1.02368928 0 1.41421358l-.5857864.5857864c-.1952622.1952622-.4511845.2928932-.7071068.2928932zm-7-9.17157284-7.58578644 7.58578644.58578644.5857864 7-6.99999996 7 6.99999996.5857864-.5857864z" fill-rule="evenodd"/></symbol><symbol id="icon-image" viewBox="0 0 18 18"><path d="m10.0046024 0c.5497429 0 1.3179837.32258606 1.707238.71184039l4.5763192 4.57631922c.3931386.39313859.7118404 1.16760135.7118404 1.71431368v8.98899651c0 1.1092806-.8945138 2.0085302-1.9940603 2.0085302h-12.01187942c-1.10128908 0-1.99406028-.8926228-1.99406028-1.9950893v-14.00982141c0-1.10185739.88743329-1.99508929 1.99961498-1.99508929zm-3.49645283 10.1752453-3.89407257 6.7495552c.11705545.048464.24538859.0751995.37998328.0751995h10.60290092l-2.4329715-4.2154691-1.57494129 2.7288098zm8.49779013 6.8247547c.5463747 0 .9940603-.4506622.9940603-1.0085302v-8.98899651c0-.28393444-.2150684-.80332809-.4189472-1.0072069l-4.5763192-4.57631922c-.2038461-.20384606-.718603-.41894717-1.0001312-.41894717h-7.00498742c-.55709576 0-.99961498.44271433-.99961498.99508929v13.98991071l4.50814957-7.81026689 3.08089884 5.33809539 1.57494129-2.7288097 3.5875735 6.2159812zm-3.0059397-11c1.1045695 0 2 .8954305 2 2s-.8954305 2-2 2-2-.8954305-2-2 .8954305-2 2-2zm0 1c-.5522847 0-1 .44771525-1 1s.4477153 1 1 1 1-.44771525 1-1-.4477153-1-1-1z" fill-rule="evenodd"/></symbol><symbol id="icon-info" viewBox="0 0 18 18"><path d="m9 0c4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9zm0 7h-1.5l-.11662113.00672773c-.49733868.05776511-.88337887.48043643-.88337887.99327227 0 .47338693.32893365.86994729.77070917.97358929l.1126697.01968298.11662113.00672773h.5v3h-.5l-.11662113.0067277c-.42082504.0488782-.76196299.3590206-.85696816.7639815l-.01968298.1126697-.00672773.1166211.00672773.1166211c.04887817.4208251.35902055.761963.76398144.8569682l.1126697.019683.11662113.0067277h3l.1166211-.0067277c.4973387-.0577651.8833789-.4804365.8833789-.9932723 0-.4733869-.3289337-.8699473-.7707092-.9735893l-.1126697-.019683-.1166211-.0067277h-.5v-4l-.00672773-.11662113c-.04887817-.42082504-.35902055-.76196299-.76398144-.85696816l-.1126697-.01968298zm0-3.25c-.69035594 0-1.25.55964406-1.25 1.25s.55964406 1.25 1.25 1.25 1.25-.55964406 1.25-1.25-.55964406-1.25-1.25-1.25z" fill-rule="evenodd"/></symbol><symbol id="icon-institution" viewBox="0 0 18 18"><path d="m7 16.9998189v-2.0003623h4v2.0003623h2v-3.0005434h-8v3.0005434zm-3-10.00181122h-1.52632364c-.27614237 0-.5-.22389817-.5-.50009056 0-.13995446.05863589-.27350497.16166338-.36820841l1.23156713-1.13206327h-2.36690687v12.00217346h3v-2.0003623h-3v-1.0001811h3v-1.0001811h1v-4.00072448h-1zm10 0v2.00036224h-1v4.00072448h1v1.0001811h3v1.0001811h-3v2.0003623h3v-12.00217346h-2.3695309l1.2315671 1.13206327c.2033191.186892.2166633.50325042.0298051.70660631-.0946863.10304615-.2282126.16169266-.3681417.16169266zm3-3.00054336c.5522847 0 1 .44779634 1 1.00018112v13.00235456h-18v-13.00235456c0-.55238478.44771525-1.00018112 1-1.00018112h3.45499992l4.20535144-3.86558216c.19129876-.17584288.48537447-.17584288.67667324 0l4.2053514 3.86558216zm-4 3.00054336h-8v1.00018112h8zm-2 6.00108672h1v-4.00072448h-1zm-1 0v-4.00072448h-2v4.00072448zm-3 0v-4.00072448h-1v4.00072448zm8-4.00072448c.5522847 0 1 .44779634 1 1.00018112v2.00036226h-2v-2.00036226c0-.55238478.4477153-1.00018112 1-1.00018112zm-12 0c.55228475 0 1 .44779634 1 1.00018112v2.00036226h-2v-2.00036226c0-.55238478.44771525-1.00018112 1-1.00018112zm5.99868798-7.81907007-5.24205601 4.81852671h10.48411203zm.00131202 3.81834559c-.55228475 0-1-.44779634-1-1.00018112s.44771525-1.00018112 1-1.00018112 1 .44779634 1 1.00018112-.44771525 1.00018112-1 1.00018112zm-1 11.00199236v1.0001811h2v-1.0001811z" fill-rule="evenodd"/></symbol><symbol id="icon-location" viewBox="0 0 18 18"><path d="m9.39521328 16.2688008c.79596342-.7770119 1.59208152-1.6299956 2.33285652-2.5295081 1.4020032-1.7024324 2.4323601-3.3624519 2.9354918-4.871847.2228715-.66861448.3364384-1.29323246.3364384-1.8674457 0-3.3137085-2.6862915-6-6-6-3.36356866 0-6 2.60156856-6 6 0 .57421324.11356691 1.19883122.3364384 1.8674457.50313169 1.5093951 1.53348863 3.1694146 2.93549184 4.871847.74077492.8995125 1.53689309 1.7524962 2.33285648 2.5295081.13694479.1336842.26895677.2602648.39521328.3793207.12625651-.1190559.25826849-.2456365.39521328-.3793207zm-.39521328 1.7311992s-7-6-7-11c0-4 3.13400675-7 7-7 3.8659932 0 7 3.13400675 7 7 0 5-7 11-7 11zm0-8c-1.65685425 0-3-1.34314575-3-3s1.34314575-3 3-3c1.6568542 0 3 1.34314575 3 3s-1.3431458 3-3 3zm0-1c1.1045695 0 2-.8954305 2-2s-.8954305-2-2-2-2 .8954305-2 2 .8954305 2 2 2z" fill-rule="evenodd"/></symbol><symbol id="icon-minus" viewBox="0 0 16 16"><path d="m2.00087166 7h11.99825664c.5527662 0 1.0008717.44386482 1.0008717 1 0 .55228475-.4446309 1-1.0008717 1h-11.99825664c-.55276616 0-1.00087166-.44386482-1.00087166-1 0-.55228475.44463086-1 1.00087166-1z" fill-rule="evenodd"/></symbol><symbol id="icon-newsletter" viewBox="0 0 18 18"><path d="m9 11.8482489 2-1.1428571v-1.7053918h-4v1.7053918zm-3-1.7142857v-2.1339632h6v2.1339632l3-1.71428574v-6.41967746h-12v6.41967746zm10-5.3839632 1.5299989.95624934c.2923814.18273835.4700011.50320827.4700011.8479983v8.44575236c0 1.1045695-.8954305 2-2 2h-14c-1.1045695 0-2-.8954305-2-2v-8.44575236c0-.34479003.1776197-.66525995.47000106-.8479983l1.52999894-.95624934v-2.75c0-.55228475.44771525-1 1-1h12c.5522847 0 1 .44771525 1 1zm0 1.17924764v3.07075236l-7 4-7-4v-3.07075236l-1 .625v8.44575236c0 .5522847.44771525 1 1 1h14c.5522847 0 1-.4477153 1-1v-8.44575236zm-10-1.92924764h6v1h-6zm-1 2h8v1h-8z" fill-rule="evenodd"/></symbol><symbol id="icon-orcid" viewBox="0 0 18 18"><path d="m9 1c4.418278 0 8 3.581722 8 8s-3.581722 8-8 8-8-3.581722-8-8 3.581722-8 8-8zm-2.90107518 5.2732337h-1.41865256v7.1712107h1.41865256zm4.55867178.02508949h-2.99247027v7.14612121h2.91062487c.7673039 0 1.4476365-.1483432 2.0410182-.445034s1.0511995-.7152915 1.3734671-1.2558144c.3222677-.540523.4833991-1.1603247.4833991-1.85942385 0-.68545815-.1602789-1.30270225-.4808414-1.85175082-.3205625-.54904856-.7707074-.97532211-1.3504481-1.27883343-.5797408-.30351132-1.2413173-.45526471-1.9847495-.45526471zm-.1892674 1.07933542c.7877654 0 1.4143875.22336734 1.8798852.67010873.4654977.44674138.698243 1.05546001.698243 1.82617415 0 .74343221-.2310402 1.34447791-.6931277 1.80315511-.4620874.4586773-1.0750688.6880124-1.8389625.6880124h-1.46810075v-4.98745039zm-5.08652545-3.71099194c-.21825533 0-.410525.08444276-.57681478.25333081-.16628977.16888806-.24943341.36245684-.24943341.58071218 0 .22345188.08314364.41961891.24943341.58850696.16628978.16888806.35855945.25333082.57681478.25333082.233845 0 .43390938-.08314364.60019916-.24943342.16628978-.16628977.24943342-.36375592.24943342-.59240436 0-.233845-.08314364-.43131115-.24943342-.59240437s-.36635416-.24163862-.60019916-.24163862z" fill-rule="evenodd"/></symbol><symbol id="icon-plus" viewBox="0 0 16 16"><path d="m2.00087166 7h4.99912834v-4.99912834c0-.55276616.44386482-1.00087166 1-1.00087166.55228475 0 1 .44463086 1 1.00087166v4.99912834h4.9991283c.5527662 0 1.0008717.44386482 1.0008717 1 0 .55228475-.4446309 1-1.0008717 1h-4.9991283v4.9991283c0 .5527662-.44386482 1.0008717-1 1.0008717-.55228475 0-1-.4446309-1-1.0008717v-4.9991283h-4.99912834c-.55276616 0-1.00087166-.44386482-1.00087166-1 0-.55228475.44463086-1 1.00087166-1z" fill-rule="evenodd"/></symbol><symbol id="icon-print" viewBox="0 0 18 18"><path d="m16.0049107 5h-14.00982141c-.54941618 0-.99508929.4467783-.99508929.99961498v6.00077002c0 .5570958.44271433.999615.99508929.999615h1.00491071v-3h12v3h1.0049107c.5494162 0 .9950893-.4467783.9950893-.999615v-6.00077002c0-.55709576-.4427143-.99961498-.9950893-.99961498zm-2.0049107-1v-2.00208688c0-.54777062-.4519464-.99791312-1.0085302-.99791312h-7.9829396c-.55661731 0-1.0085302.44910695-1.0085302.99791312v2.00208688zm1 10v2.0018986c0 1.103521-.9019504 1.9981014-2.0085302 1.9981014h-7.9829396c-1.1092806 0-2.0085302-.8867064-2.0085302-1.9981014v-2.0018986h-1.00491071c-1.10185739 0-1.99508929-.8874333-1.99508929-1.999615v-6.00077002c0-1.10435686.8926228-1.99961498 1.99508929-1.99961498h1.00491071v-2.00208688c0-1.10341695.90195036-1.99791312 2.0085302-1.99791312h7.9829396c1.1092806 0 2.0085302.89826062 2.0085302 1.99791312v2.00208688h1.0049107c1.1018574 0 1.9950893.88743329 1.9950893 1.99961498v6.00077002c0 1.1043569-.8926228 1.999615-1.9950893 1.999615zm-1-3h-10v5.0018986c0 .5546075.44702548.9981014 1.0085302.9981014h7.9829396c.5565964 0 1.0085302-.4491701 1.0085302-.9981014zm-9 1h8v1h-8zm0 2h5v1h-5zm9-5c-.5522847 0-1-.44771525-1-1s.4477153-1 1-1 1 .44771525 1 1-.4477153 1-1 1z" fill-rule="evenodd"/></symbol><symbol id="icon-search" viewBox="0 0 22 22"><path d="M21.697 20.261a1.028 1.028 0 01.01 1.448 1.034 1.034 0 01-1.448-.01l-4.267-4.267A9.812 9.811 0 010 9.812a9.812 9.811 0 1117.43 6.182zM9.812 18.222A8.41 8.41 0 109.81 1.403a8.41 8.41 0 000 16.82z" fill-rule="evenodd"/></symbol><symbol id="icon-social-facebook" viewBox="0 0 24 24"><path d="m6.00368507 20c-1.10660471 0-2.00368507-.8945138-2.00368507-1.9940603v-12.01187942c0-1.10128908.89451376-1.99406028 1.99406028-1.99406028h12.01187942c1.1012891 0 1.9940603.89451376 1.9940603 1.99406028v12.01187942c0 1.1012891-.88679 1.9940603-2.0032184 1.9940603h-2.9570132v-6.1960818h2.0797387l.3114113-2.414723h-2.39115v-1.54164807c0-.69911803.1941355-1.1755439 1.1966615-1.1755439l1.2786739-.00055875v-2.15974763l-.2339477-.02492088c-.3441234-.03134957-.9500153-.07025255-1.6293054-.07025255-1.8435726 0-3.1057323 1.12531866-3.1057323 3.19187953v1.78079225h-2.0850778v2.414723h2.0850778v6.1960818z" fill-rule="evenodd"/></symbol><symbol id="icon-social-twitter" viewBox="0 0 24 24"><path d="m18.8767135 6.87445248c.7638174-.46908424 1.351611-1.21167363 1.6250764-2.09636345-.7135248.43394112-1.50406.74870123-2.3464594.91677702-.6695189-.73342162-1.6297913-1.19486605-2.6922204-1.19486605-2.0399895 0-3.6933555 1.69603749-3.6933555 3.78628909 0 .29642457.0314329.58673729.0942985.8617704-3.06469922-.15890802-5.78835241-1.66547825-7.60988389-3.9574208-.3174714.56076194-.49978171 1.21167363-.49978171 1.90536824 0 1.31404706.65223085 2.47224203 1.64236444 3.15218497-.60350999-.0198635-1.17401554-.1925232-1.67222562-.47366811v.04583885c0 1.83355406 1.27302891 3.36609966 2.96411421 3.71294696-.31118484.0886217-.63651445.1329326-.97441718.1329326-.2357461 0-.47149219-.0229194-.69466516-.0672303.47149219 1.5065703 1.83253297 2.6036468 3.44975116 2.632678-1.2651707 1.0160946-2.85724264 1.6196394-4.5891906 1.6196394-.29861172 0-.59093688-.0152796-.88011875-.0504227 1.63450624 1.0726291 3.57548241 1.6990934 5.66104951 1.6990934 6.79263079 0 10.50641749-5.7711113 10.50641749-10.7751859l-.0094298-.48894775c.7229547-.53478659 1.3516109-1.20250585 1.8419628-1.96190282-.6632323.30100846-1.3751855.50422736-2.1217148.59590507z" fill-rule="evenodd"/></symbol><symbol id="icon-social-youtube" viewBox="0 0 24 24"><path d="m10.1415 14.3973208-.0005625-5.19318431 4.863375 2.60554491zm9.963-7.92753362c-.6845625-.73643756-1.4518125-.73990314-1.803375-.7826454-2.518875-.18714178-6.2971875-.18714178-6.2971875-.18714178-.007875 0-3.7861875 0-6.3050625.18714178-.352125.04274226-1.1188125.04620784-1.8039375.7826454-.5394375.56084773-.7149375 1.8344515-.7149375 1.8344515s-.18 1.49597903-.18 2.99138042v1.4024082c0 1.495979.18 2.9913804.18 2.9913804s.1755 1.2736038.7149375 1.8344515c.685125.7364376 1.5845625.7133337 1.9850625.7901542 1.44.1420891 6.12.1859866 6.12.1859866s3.78225-.005776 6.301125-.1929178c.3515625-.0433198 1.1188125-.0467854 1.803375-.783223.5394375-.5608477.7155-1.8344515.7155-1.8344515s.18-1.4954014.18-2.9913804v-1.4024082c0-1.49540139-.18-2.99138042-.18-2.99138042s-.1760625-1.27360377-.7155-1.8344515z" fill-rule="evenodd"/></symbol><symbol id="icon-subject-medicine" viewBox="0 0 18 18"><path d="m12.5 8h-6.5c-1.65685425 0-3 1.34314575-3 3v1c0 1.6568542 1.34314575 3 3 3h1v-2h-.5c-.82842712 0-1.5-.6715729-1.5-1.5s.67157288-1.5 1.5-1.5h1.5 2 1 2c1.6568542 0 3-1.34314575 3-3v-1c0-1.65685425-1.3431458-3-3-3h-2v2h1.5c.8284271 0 1.5.67157288 1.5 1.5s-.6715729 1.5-1.5 1.5zm-5.5-1v-1h-3.5c-1.38071187 0-2.5-1.11928813-2.5-2.5s1.11928813-2.5 2.5-2.5h1.02786405c.46573528 0 .92507448.10843528 1.34164078.31671843l1.13382424.56691212c.06026365-1.05041141.93116291-1.88363055 1.99667093-1.88363055 1.1045695 0 2 .8954305 2 2h2c2.209139 0 4 1.790861 4 4v1c0 2.209139-1.790861 4-4 4h-2v1h2c1.1045695 0 2 .8954305 2 2s-.8954305 2-2 2h-2c0 1.1045695-.8954305 2-2 2s-2-.8954305-2-2h-1c-2.209139 0-4-1.790861-4-4v-1c0-2.209139 1.790861-4 4-4zm0-2v-2.05652691c-.14564246-.03538148-.28733393-.08714006-.42229124-.15461871l-1.15541752-.57770876c-.27771087-.13885544-.583937-.21114562-.89442719-.21114562h-1.02786405c-.82842712 0-1.5.67157288-1.5 1.5s.67157288 1.5 1.5 1.5zm4 1v1h1.5c.2761424 0 .5-.22385763.5-.5s-.2238576-.5-.5-.5zm-1 1v-5c0-.55228475-.44771525-1-1-1s-1 .44771525-1 1v5zm-2 4v5c0 .5522847.44771525 1 1 1s1-.4477153 1-1v-5zm3 2v2h2c.5522847 0 1-.4477153 1-1s-.4477153-1-1-1zm-4-1v-1h-.5c-.27614237 0-.5.2238576-.5.5s.22385763.5.5.5zm-3.5-9h1c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-1c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5z" fill-rule="evenodd"/></symbol><symbol id="icon-success" viewBox="0 0 18 18"><path d="m9 0c4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9zm3.4860198 4.98163161-4.71802968 5.50657859-2.62834168-2.02300024c-.42862421-.36730544-1.06564993-.30775346-1.42283677.13301307-.35718685.44076653-.29927542 1.0958383.12934879 1.46314377l3.40735508 2.7323063c.42215801.3385221 1.03700951.2798252 1.38749189-.1324571l5.38450527-6.33394549c.3613513-.43716226.3096573-1.09278382-.115462-1.46437175-.4251192-.37158792-1.0626796-.31842941-1.4240309.11873285z" fill-rule="evenodd"/></symbol><symbol id="icon-table" viewBox="0 0 18 18"><path d="m16.0049107 2c1.1018574 0 1.9950893.89706013 1.9950893 2.00585866v9.98828264c0 1.1078052-.8926228 2.0058587-1.9950893 2.0058587l-4.0059107-.001.001.001h-1l-.001-.001h-5l.001.001h-1l-.001-.001-3.00391071.001c-1.10185739 0-1.99508929-.8970601-1.99508929-2.0058587v-9.98828264c0-1.10780515.8926228-2.00585866 1.99508929-2.00585866zm-11.0059107 5h-3.999v6.9941413c0 .5572961.44630695 1.0058587.99508929 1.0058587h3.00391071zm6 0h-5v8h5zm5.0059107-4h-4.0059107v3h5.001v1h-5.001v7.999l4.0059107.001c.5487152 0 .9950893-.4488783.9950893-1.0058587v-9.98828264c0-.55729607-.446307-1.00585866-.9950893-1.00585866zm-12.5049107 9c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-1c-.27614237 0-.5-.2238576-.5-.5s.22385763-.5.5-.5zm12 0c.2761424 0 .5.2238576.5.5s-.2238576.5-.5.5h-2c-.2761424 0-.5-.2238576-.5-.5s.2238576-.5.5-.5zm-6 0c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-2c-.27614237 0-.5-.2238576-.5-.5s.22385763-.5.5-.5zm-6-2c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-1c-.27614237 0-.5-.2238576-.5-.5s.22385763-.5.5-.5zm12 0c.2761424 0 .5.2238576.5.5s-.2238576.5-.5.5h-2c-.2761424 0-.5-.2238576-.5-.5s.2238576-.5.5-.5zm-6 0c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-2c-.27614237 0-.5-.2238576-.5-.5s.22385763-.5.5-.5zm-6-2c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-1c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5zm12 0c.2761424 0 .5.22385763.5.5s-.2238576.5-.5.5h-2c-.2761424 0-.5-.22385763-.5-.5s.2238576-.5.5-.5zm-6 0c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-2c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5zm1.499-5h-5v3h5zm-6 0h-3.00391071c-.54871518 0-.99508929.44887827-.99508929 1.00585866v1.99414134h3.999z" fill-rule="evenodd"/></symbol><symbol id="icon-tick-circle" viewBox="0 0 24 24"><path d="m12 2c5.5228475 0 10 4.4771525 10 10s-4.4771525 10-10 10-10-4.4771525-10-10 4.4771525-10 10-10zm0 1c-4.97056275 0-9 4.02943725-9 9 0 4.9705627 4.02943725 9 9 9 4.9705627 0 9-4.0294373 9-9 0-4.97056275-4.0294373-9-9-9zm4.2199868 5.36606669c.3613514-.43716226.9989118-.49032077 1.424031-.11873285s.4768133 1.02720949.115462 1.46437175l-6.093335 6.94397871c-.3622945.4128716-.9897871.4562317-1.4054264.0971157l-3.89719065-3.3672071c-.42862421-.3673054-.48653564-1.0223772-.1293488-1.4631437s.99421256-.5003185 1.42283677-.1330131l3.11097438 2.6987741z" fill-rule="evenodd"/></symbol><symbol id="icon-tick" viewBox="0 0 16 16"><path d="m6.76799012 9.21106946-3.1109744-2.58349728c-.42862421-.35161617-1.06564993-.29460792-1.42283677.12733148s-.29927541 1.04903009.1293488 1.40064626l3.91576307 3.23873978c.41034319.3393961 1.01467563.2976897 1.37450571-.0948578l6.10568327-6.660841c.3613513-.41848908.3096572-1.04610608-.115462-1.4018218-.4251192-.35571573-1.0626796-.30482786-1.424031.11366122z" fill-rule="evenodd"/></symbol><symbol id="icon-update" viewBox="0 0 18 18"><path d="m1 13v1c0 .5522847.44771525 1 1 1h14c.5522847 0 1-.4477153 1-1v-1h-1v-10h-14v10zm16-1h1v2c0 1.1045695-.8954305 2-2 2h-14c-1.1045695 0-2-.8954305-2-2v-2h1v-9c0-.55228475.44771525-1 1-1h14c.5522847 0 1 .44771525 1 1zm-1 0v1h-4.5857864l-1 1h-2.82842716l-1-1h-4.58578644v-1h5l1 1h2l1-1zm-13-8h12v7h-12zm1 1v5h10v-5zm1 1h4v1h-4zm0 2h4v1h-4z" fill-rule="evenodd"/></symbol><symbol id="icon-upload" viewBox="0 0 18 18"><path d="m10.0046024 0c.5497429 0 1.3179837.32258606 1.707238.71184039l4.5763192 4.57631922c.3931386.39313859.7118404 1.16760135.7118404 1.71431368v8.98899651c0 1.1092806-.8945138 2.0085302-1.9940603 2.0085302h-12.01187942c-1.10128908 0-1.99406028-.8926228-1.99406028-1.9950893v-14.00982141c0-1.10185739.88743329-1.99508929 1.99961498-1.99508929zm0 1h-7.00498742c-.55709576 0-.99961498.44271433-.99961498.99508929v14.00982141c0 .5500396.44491393.9950893.99406028.9950893h12.01187942c.5463747 0 .9940603-.4506622.9940603-1.0085302v-8.98899651c0-.28393444-.2150684-.80332809-.4189472-1.0072069l-4.5763192-4.57631922c-.2038461-.20384606-.718603-.41894717-1.0001312-.41894717zm-1.85576936 4.14572769c.19483374-.19483375.51177826-.19377714.70556874.00001334l2.59099082 2.59099079c.1948411.19484112.1904373.51514474.0027906.70279143-.1932998.19329987-.5046517.19237083-.7001856-.00692852l-1.74638687-1.7800176v6.14827687c0 .2717771-.23193359.492096-.5.492096-.27614237 0-.5-.216372-.5-.492096v-6.14827641l-1.74627892 1.77990922c-.1933927.1971171-.51252214.19455839-.70016883.0069117-.19329987-.19329988-.19100584-.50899493.00277731-.70277808z" fill-rule="evenodd"/></symbol><symbol id="icon-video" viewBox="0 0 18 18"><path d="m16.0049107 2c1.1018574 0 1.9950893.89706013 1.9950893 2.00585866v9.98828264c0 1.1078052-.8926228 2.0058587-1.9950893 2.0058587h-14.00982141c-1.10185739 0-1.99508929-.8970601-1.99508929-2.0058587v-9.98828264c0-1.10780515.8926228-2.00585866 1.99508929-2.00585866zm0 1h-14.00982141c-.54871518 0-.99508929.44887827-.99508929 1.00585866v9.98828264c0 .5572961.44630695 1.0058587.99508929 1.0058587h14.00982141c.5487152 0 .9950893-.4488783.9950893-1.0058587v-9.98828264c0-.55729607-.446307-1.00585866-.9950893-1.00585866zm-8.30912922 2.24944486 4.60460462 2.73982242c.9365543.55726659.9290753 1.46522435 0 2.01804082l-4.60460462 2.7398224c-.93655425.5572666-1.69578148.1645632-1.69578148-.8937585v-5.71016863c0-1.05087579.76670616-1.446575 1.69578148-.89375851zm-.67492769.96085624v5.5750128c0 .2995102-.10753745.2442517.16578928.0847713l4.58452283-2.67497259c.3050619-.17799716.3051624-.21655446 0-.39461026l-4.58452283-2.67497264c-.26630747-.15538481-.16578928-.20699944-.16578928.08477139z" fill-rule="evenodd"/></symbol><symbol id="icon-warning" viewBox="0 0 18 18"><path d="m9 11.75c.69035594 0 1.25.5596441 1.25 1.25s-.55964406 1.25-1.25 1.25-1.25-.5596441-1.25-1.25.55964406-1.25 1.25-1.25zm.41320045-7.75c.55228475 0 1.00000005.44771525 1.00000005 1l-.0034543.08304548-.3333333 4c-.043191.51829212-.47645714.91695452-.99654578.91695452h-.15973424c-.52008864 0-.95335475-.3986624-.99654576-.91695452l-.33333333-4c-.04586475-.55037702.36312325-1.03372649.91350028-1.07959124l.04148683-.00259031zm-.41320045 14c-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9 4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9z" fill-rule="evenodd"/></symbol><symbol id="icon-arrow-left-bullet" viewBox="0 0 8 16"><path d="M3 8l5 5v3L0 8l8-8v3L3 8z"/></symbol><symbol id="icon-chevron-down" viewBox="0 0 16 16"><path d="m5.58578644 3-3.29289322-3.29289322c-.39052429-.39052429-.39052429-1.02368927 0-1.41421356s1.02368927-.39052429 1.41421356 0l4 4c.39052429.39052429.39052429 1.02368927 0 1.41421356l-4 4c-.39052429.39052429-1.02368927.39052429-1.41421356 0s-.39052429-1.02368927 0-1.41421356z" fill-rule="evenodd" transform="matrix(0 1 -1 0 11 3)"/></symbol><symbol id="icon-download-rounded"><path d="M0 13c0-.556.449-1 1.002-1h9.996a.999.999 0 110 2H1.002A1.006 1.006 0 010 13zM7 1v6.8l2.482-2.482c.392-.392 1.022-.4 1.403-.02a1.001 1.001 0 010 1.417l-4.177 4.177a1.001 1.001 0 01-1.416 0L1.115 6.715a.991.991 0 01-.016-1.4 1 1 0 011.42.003L5 7.8V1c0-.55.444-.996 1-.996.552 0 1 .445 1 .996z"/></symbol><symbol id="icon-ext-link" viewBox="0 0 16 16"><path d="M12.9 16H3.1C1.4 16 0 14.6 0 12.9V3.2C0 1.4 1.4 0 3.1 0h3.7v1H3.1C2 1 1 2 1 3.2v9.7C1 14 2 15 3.1 15h9.7c1.2 0 2.1-1 2.1-2.1V8.7h1v4.2c.1 1.7-1.3 3.1-3 3.1z"/><path d="M12.8 2.5l.7.7-9 8.9-.7-.7 9-8.9z"/><path d="M9.7 0L16 6.2V0z"/></symbol><symbol id="icon-remove" viewBox="-296 388 18 18"><path d="M-291.7 396.1h9v2h-9z"/><path d="M-287 405.5c-4.7 0-8.5-3.8-8.5-8.5s3.8-8.5 8.5-8.5 8.5 3.8 8.5 8.5-3.8 8.5-8.5 8.5zm0-16c-4.1 0-7.5 3.4-7.5 7.5s3.4 7.5 7.5 7.5 7.5-3.4 7.5-7.5-3.4-7.5-7.5-7.5z"/></symbol><symbol id="icon-rss" viewBox="0 0 18 18"><path d="m.97480857 6.01583891.11675372.00378391c5.75903295.51984988 10.34261021 5.10537458 10.85988231 10.86480098.0494035.5500707-.3564674 1.0360406-.906538 1.0854441-.5500707.0494036-1.0360406-.3564673-1.08544412-.906538-.43079083-4.7965248-4.25151132-8.61886853-9.04770289-9.05180573-.55004837-.04965115-.95570047-.53580366-.90604933-1.08585203.04610464-.5107592.46858035-.89701345.96909831-.90983323zm1.52519143 6.95474179c1.38071187 0 2.5 1.1192881 2.5 2.5s-1.11928813 2.5-2.5 2.5-2.5-1.1192881-2.5-2.5 1.11928813-2.5 2.5-2.5zm-1.43253846-12.96884168c9.09581416.53242539 16.37540296 7.8163886 16.90205336 16.91294558.0319214.5513615-.389168 1.0242056-.9405294 1.056127-.5513615.0319214-1.0242057-.389168-1.0561271-.9405294-.4679958-8.08344784-6.93949306-14.55883389-15.02226722-15.03196077-.55134101-.03227286-.97212889-.50538538-.93985602-1.05672639.03227286-.551341.50538538-.97212888 1.05672638-.93985602z" fill-rule="evenodd"/></symbol><symbol id="icon-springer-arrow-left"><path d="M15 7a1 1 0 000-2H3.385l2.482-2.482a.994.994 0 00.02-1.403 1.001 1.001 0 00-1.417 0L.294 5.292a1.001 1.001 0 000 1.416l4.176 4.177a.991.991 0 001.4.016 1 1 0 00-.003-1.42L3.385 7H15z"/></symbol><symbol id="icon-springer-arrow-right"><path d="M1 7a1 1 0 010-2h11.615l-2.482-2.482a.994.994 0 01-.02-1.403 1.001 1.001 0 011.417 0l4.176 4.177a1.001 1.001 0 010 1.416l-4.176 4.177a.991.991 0 01-1.4.016 1 1 0 01.003-1.42L12.615 7H1z"/></symbol><symbol id="icon-springer-collections" viewBox="3 3 32 32"><path fill-rule="evenodd" d="M25.583333,30.1249997 L25.583333,7.1207574 C25.583333,7.10772495 25.579812,7.10416665 25.5859851,7.10416665 L6.10400517,7.10571021 L6.10400517,30.1355179 C6.10400517,31.1064087 6.89406744,31.8958329 7.86448169,31.8958329 L26.057145,31.8958329 C25.7558021,31.374901 25.583333,30.7700915 25.583333,30.1249997 Z M4.33333333,30.1355179 L4.33333333,7.10571021 C4.33333333,6.12070047 5.12497502,5.33333333 6.10151452,5.33333333 L25.5859851,5.33333333 C26.5617372,5.33333333 27.3541664,6.13359035 27.3541664,7.1207574 L27.3541664,12.4166666 L32.6666663,12.4166666 L32.6666663,30.1098941 C32.6666663,32.0694626 31.0857174,33.6666663 29.1355179,33.6666663 L7.86448169,33.6666663 C5.91736809,33.6666663 4.33333333,32.0857174 4.33333333,30.1355179 Z M27.3541664,14.1874999 L27.3541664,30.1249997 C27.3541664,31.1030039 28.1469954,31.8958329 29.1249997,31.8958329 C30.1030039,31.8958329 30.8958329,31.1030039 30.8958329,30.1249997 L30.8958329,14.1874999 L27.3541664,14.1874999 Z M9.64583326,10.6458333 L22.0416665,10.6458333 L22.0416665,17.7291665 L9.64583326,17.7291665 L9.64583326,10.6458333 Z M11.4166666,12.4166666 L11.4166666,15.9583331 L20.2708331,15.9583331 L20.2708331,12.4166666 L11.4166666,12.4166666 Z M9.64583326,19.4999998 L22.0416665,19.4999998 L22.0416665,21.2708331 L9.64583326,21.2708331 L9.64583326,19.4999998 Z M9.64583326,23.0416665 L22.0416665,23.0416665 L22.0416665,24.8124997 L9.64583326,24.8124997 L9.64583326,23.0416665 Z M9.64583326,26.583333 L22.0416665,26.583333 L22.0416665,28.3541664 L9.64583326,28.3541664 L9.64583326,26.583333 Z"/></symbol><symbol id="icon-springer-download" viewBox="-301 390 9 14"><path d="M-301 395.6l4.5 5.1 4.5-5.1h-3V390h-3v5.6h-3zm0 6.5h9v1.9h-9z"/></symbol><symbol id="icon-springer-info" viewBox="0 0 24 24"><!--Generator: Sketch 63.1 (92452) - https://sketch.com--><g id="V&I" stroke="none" stroke-width="1" fill-rule="evenodd"><g id="info" fill-rule="nonzero"><path d="M12,0 C18.627417,0 24,5.372583 24,12 C24,18.627417 18.627417,24 12,24 C5.372583,24 0,18.627417 0,12 C0,5.372583 5.372583,0 12,0 Z M12.5540543,9.1 L11.5540543,9.1 C11.0017696,9.1 10.5540543,9.54771525 10.5540543,10.1 L10.5540543,10.1 L10.5540543,18.1 C10.5540543,18.6522847 11.0017696,19.1 11.5540543,19.1 L11.5540543,19.1 L12.5540543,19.1 C13.1063391,19.1 13.5540543,18.6522847 13.5540543,18.1 L13.5540543,18.1 L13.5540543,10.1 C13.5540543,9.54771525 13.1063391,9.1 12.5540543,9.1 L12.5540543,9.1 Z M12,5 C11.5356863,5 11.1529412,5.14640523 10.8517647,5.43921569 C10.5505882,5.73202614 10.4,6.11546841 10.4,6.58954248 C10.4,7.06361656 10.5505882,7.45054466 10.8517647,7.7503268 C11.1529412,8.05010893 11.5356863,8.2 12,8.2 C12.4768627,8.2 12.8627451,8.05010893 13.1576471,7.7503268 C13.452549,7.45054466 13.6,7.06361656 13.6,6.58954248 C13.6,6.11546841 13.452549,5.73202614 13.1576471,5.43921569 C12.8627451,5.14640523 12.4768627,5 12,5 Z" id="Combined-Shape"/></g></g></symbol><symbol id="icon-springer-tick-circle" viewBox="0 0 24 24"><g id="Page-1" stroke="none" stroke-width="1" fill-rule="evenodd"><g id="springer-tick-circle" fill-rule="nonzero"><path d="M12,24 C5.372583,24 0,18.627417 0,12 C0,5.372583 5.372583,0 12,0 C18.627417,0 24,5.372583 24,12 C24,18.627417 18.627417,24 12,24 Z M7.657,10.79 C7.45285634,10.6137568 7.18569967,10.5283283 6.91717333,10.5534259 C6.648647,10.5785236 6.40194824,10.7119794 6.234,10.923 C5.87705269,11.3666969 5.93445559,12.0131419 6.364,12.387 L10.261,15.754 C10.6765468,16.112859 11.3037113,16.0695601 11.666,15.657 L17.759,8.713 C18.120307,8.27302248 18.0695334,7.62621189 17.644,7.248 C17.4414817,7.06995024 17.1751516,6.9821166 16.9064461,7.00476032 C16.6377406,7.02740404 16.3898655,7.15856958 16.22,7.368 L10.768,13.489 L7.657,10.79 Z" id="path-1"/></g></g></symbol><symbol id="icon-updates" viewBox="0 0 18 18"><g fill-rule="nonzero"><path d="M16.98 3.484h-.48c-2.52-.058-5.04 1.161-7.44 2.903-2.46-1.8-4.74-2.903-8.04-2.903-.3 0-.54.29-.54.58v9.813c0 .29.24.523.54.581 2.76.348 4.86 1.045 7.62 2.903.24.116.54.116.72 0 2.76-1.858 4.86-2.555 7.62-2.903.3-.058.54-.29.54-.58V4.064c0-.29-.24-.523-.54-.581zm-15.3 1.22c2.34 0 4.86 1.509 6.72 2.786v8.478c-2.34-1.394-4.38-2.09-6.72-2.439V4.703zm14.58 8.767c-2.34.348-4.38 1.045-6.72 2.439V7.374C12 5.632 14.1 4.645 16.26 4.645v8.826z"/><path d="M9 .058c-1.56 0-2.76 1.22-2.76 2.671C6.24 4.181 7.5 5.4 9 5.4c1.5 0 2.76-1.22 2.76-2.671 0-1.452-1.2-2.67-2.76-2.67zm0 4.413c-.96 0-1.8-.755-1.8-1.742C7.2 1.8 7.98.987 9 .987s1.8.755 1.8 1.742c0 .93-.84 1.742-1.8 1.742z"/></g></symbol><symbol id="icon-checklist-banner" viewBox="0 0 56.69 56.69"><path style="fill:none" d="M0 0h56.69v56.69H0z"/><clipPath id="b"><use xlink:href="#a" style="overflow:visible"/></clipPath><path d="M21.14 34.46c0-6.77 5.48-12.26 12.24-12.26s12.24 5.49 12.24 12.26-5.48 12.26-12.24 12.26c-6.76-.01-12.24-5.49-12.24-12.26zm19.33 10.66 10.23 9.22s1.21 1.09 2.3-.12l2.09-2.32s1.09-1.21-.12-2.3l-10.23-9.22m-19.29-5.92c0-4.38 3.55-7.94 7.93-7.94s7.93 3.55 7.93 7.94c0 4.38-3.55 7.94-7.93 7.94-4.38-.01-7.93-3.56-7.93-7.94zm17.58 12.99 4.14-4.81" style="clip-path:url(#b);fill:none;stroke:#01324b;stroke-width:2;stroke-linecap:round"/><path d="M8.26 9.75H28.6M8.26 15.98H28.6m-20.34 6.2h12.5m14.42-5.2V4.86s0-2.93-2.93-2.93H4.13s-2.93 0-2.93 2.93v37.57s0 2.93 2.93 2.93h15.01M8.26 9.75H28.6M8.26 15.98H28.6m-20.34 6.2h12.5" style="clip-path:url(#b);fill:none;stroke:#01324b;stroke-width:2;stroke-linecap:round;stroke-linejoin:round"/></symbol><symbol id="icon-submit-closed" viewBox="0 0 18 18"><path d="m15 0c1.1045695 0 2 .8954305 2 2v4.5c0 .27614237-.2238576.5-.5.5s-.5-.22385763-.5-.5v-4.5c0-.51283584-.3860402-.93550716-.8833789-.99327227l-.1166211-.00672773h-9v3c0 1.1045695-.8954305 2-2 2h-3v10c0 .5128358.38604019.9355072.88337887.9932723l.11662113.0067277h4.5c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-4.5c-1.1045695 0-2-.8954305-2-2v-10.17157288c0-.53043297.21071368-1.0391408.58578644-1.41421356l3.82842712-3.82842712c.37507276-.37507276.88378059-.58578644 1.41421356-.58578644zm-2.5 7c3.0375661 0 5.5 2.46243388 5.5 5.5 0 3.0375661-2.4624339 5.5-5.5 5.5-3.03756612 0-5.5-2.4624339-5.5-5.5 0-3.03756612 2.46243388-5.5 5.5-5.5zm0 1c-2.4852814 0-4.5 2.0147186-4.5 4.5s2.0147186 4.5 4.5 4.5 4.5-2.0147186 4.5-4.5-2.0147186-4.5-4.5-4.5zm2.3087379 2.1912621c.2550161.2550162.2550161.668479 0 .9234952l-1.3859024 1.3845831 1.3859024 1.3859023c.2550161.2550162.2550161.668479 0 .9234952-.2550162.2550161-.668479.2550161-.9234952 0l-1.3859023-1.3859024-1.3845831 1.3859024c-.2550162.2550161-.668479.2550161-.9234952 0-.25501614-.2550162-.25501614-.668479 0-.9234952l1.3845831-1.3859023-1.3845831-1.3845831c-.25501614-.2550162-.25501614-.668479 0-.9234952.2550162-.25501614.668479-.25501614.9234952 0l1.3845831 1.3845831 1.3859023-1.3845831c.2550162-.25501614.668479-.25501614.9234952 0zm-9.8087379-8.7782621-3.587 3.587h2.587c.55228475 0 1-.44771525 1-1z"/></symbol><symbol id="icon-submit-open" viewBox="0 0 18 18"><path d="m15 0c1.1045695 0 2 .8954305 2 2v5.5c0 .27614237-.2238576.5-.5.5s-.5-.22385763-.5-.5v-5.5c0-.51283584-.3860402-.93550716-.8833789-.99327227l-.1166211-.00672773h-9v3c0 1.1045695-.8954305 2-2 2h-3v10c0 .5128358.38604019.9355072.88337887.9932723l.11662113.0067277h7.5c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-7.5c-1.1045695 0-2-.8954305-2-2v-10.17157288c0-.53043297.21071368-1.0391408.58578644-1.41421356l3.82842712-3.82842712c.37507276-.37507276.88378059-.58578644 1.41421356-.58578644zm-.5442863 8.18867991 3.3545404 3.35454039c.2508994.2508994.2538696.6596433.0035959.909917-.2429543.2429542-.6561449.2462671-.9065387-.0089489l-2.2609825-2.3045251.0010427 7.2231989c0 .3569916-.2898381.6371378-.6473715.6371378-.3470771 0-.6473715-.2852563-.6473715-.6371378l-.0010428-7.2231995-2.2611222 2.3046654c-.2531661.2580415-.6562868.2592444-.9065605.0089707-.24295423-.2429542-.24865597-.6576651.0036132-.9099343l3.3546673-3.35466731c.2509089-.25090888.6612706-.25227691.9135302-.00001728zm-.9557137-3.18867991c.2761424 0 .5.22385763.5.5s-.2238576.5-.5.5h-6c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5zm-8.5-3.587-3.587 3.587h2.587c.55228475 0 1-.44771525 1-1zm8.5 1.587c.2761424 0 .5.22385763.5.5s-.2238576.5-.5.5h-6c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5z"/></symbol><symbol id="icon-submit-upcoming" viewBox="0 0 18 18"><path d="m15 0c1.1045695 0 2 .8954305 2 2v4.5c0 .27614237-.2238576.5-.5.5s-.5-.22385763-.5-.5v-4.5c0-.51283584-.3860402-.93550716-.8833789-.99327227l-.1166211-.00672773h-9v3c0 1.1045695-.8954305 2-2 2h-3v10c0 .5128358.38604019.9355072.88337887.9932723l.11662113.0067277h4.5c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-4.5c-1.1045695 0-2-.8954305-2-2v-10.17157288c0-.53043297.21071368-1.0391408.58578644-1.41421356l3.82842712-3.82842712c.37507276-.37507276.88378059-.58578644 1.41421356-.58578644zm-2.5 7c3.0375661 0 5.5 2.46243388 5.5 5.5 0 3.0375661-2.4624339 5.5-5.5 5.5-3.03756612 0-5.5-2.4624339-5.5-5.5 0-1.6607442.73606908-3.14957021 1.89976608-4.15803695l-1.51549374.02214397c-.27613212.00263356-.49998143-.22483432-.49998143-.49020681 0-.24299316.17766103-.44509007.40961587-.48700057l.08928713-.00797472h2.66407569c.2449213 0 .4486219.17766776.490865.40963137l.008038.08929051v2.6642143c0 .275547-.2296028.4989219-.4949753.4989219-.24299317 0-.44342617-.1744719-.4830969-.4093269l-.00710993-.0906783.01983146-1.46576707c-.96740882.82538117-1.58082193 2.05345007-1.58082193 3.42478927 0 2.4852814 2.0147186 4.5 4.5 4.5s4.5-2.0147186 4.5-4.5-2.0147186-4.5-4.5-4.5c-.7684937 0-.7684937-1 0-1zm0 2.85c.3263501 0 .5965265.2405082.6429523.5539478l.0070477.0960522v1.731l.8096194.8093806c.2284567.2284567.2513024.5846637.068537.8386705l-.068537.0805683c-.2284567.2284567-.5846637.2513024-.8386705.068537l-.0805683-.068537-.9707107-.9707107c-.1125218-.1125218-.1855975-.257116-.2103268-.412296l-.0093431-.1180341v-1.9585786c0-.3589851.2910149-.65.65-.65zm-7.5-8.437-3.587 3.587h2.587c.55228475 0 1-.44771525 1-1z"/></symbol><symbol id="icon-facebook-bordered" viewBox="463.812 263.868 32 32"><path d="M479.812,263.868c-8.837,0-16,7.163-16,16s7.163,16,16,16s16-7.163,16-16S488.649,263.868,479.812,263.868z M479.812,293.868c-7.732,0-14-6.269-14-14s6.268-14,14-14s14,6.269,14,14S487.545,293.868,479.812,293.868z"/><path d="M483.025,280.48l0.32-2.477h-2.453v-1.582c0-0.715,0.199-1.207,1.227-1.207h1.311v-2.213 c-0.227-0.029-1.003-0.098-1.907-0.098c-1.894,0-3.186,1.154-3.186,3.271v1.826h-2.142v2.477h2.142v6.354h2.557v-6.354 L483.025,280.48L483.025,280.48z"/></symbol><symbol id="icon-twitter-bordered" viewBox="463.812 263.868 32 32"><g><path d="M486.416,276.191c-0.483,0.215-1.007,0.357-1.554,0.429c0.558-0.338,0.991-0.868,1.19-1.502 c-0.521,0.308-1.104,0.536-1.72,0.657c-0.494-0.526-1.2-0.854-1.979-0.854c-1.496,0-2.711,1.213-2.711,2.71 c0,0.212,0.023,0.419,0.069,0.616c-2.252-0.111-4.25-1.19-5.586-2.831c-0.231,0.398-0.365,0.866-0.365,1.361 c0,0.94,0.479,1.772,1.204,2.257c-0.441-0.015-0.861-0.138-1.227-0.339v0.031c0,1.314,0.937,2.41,2.174,2.656 c-0.227,0.062-0.47,0.098-0.718,0.098c-0.171,0-0.343-0.018-0.511-0.049c0.35,1.074,1.347,1.859,2.531,1.883 c-0.928,0.726-2.095,1.16-3.366,1.16c-0.22,0-0.433-0.014-0.644-0.037c1.2,0.768,2.621,1.215,4.155,1.215 c4.983,0,7.71-4.129,7.71-7.711c0-0.115-0.004-0.232-0.006-0.351C485.592,277.212,486.054,276.734,486.416,276.191z"/></g><path d="M479.812,263.868c-8.837,0-16,7.163-16,16s7.163,16,16,16s16-7.163,16-16S488.649,263.868,479.812,263.868z M479.812,293.868c-7.732,0-14-6.269-14-14s6.268-14,14-14s14,6.269,14,14S487.545,293.868,479.812,293.868z"/></symbol><symbol id="icon-weibo-bordered" viewBox="463.812 263.868 32 32"><path d="M479.812,263.868c-8.838,0-16,7.163-16,16s7.162,16,16,16c8.837,0,16-7.163,16-16S488.649,263.868,479.812,263.868z M479.812,293.868c-7.732,0-14-6.269-14-14s6.268-14,14-14c7.731,0,14,6.269,14,14S487.545,293.868,479.812,293.868z"/><g><path d="M478.552,285.348c-2.616,0.261-4.876-0.926-5.044-2.649c-0.167-1.722,1.814-3.33,4.433-3.588 c2.609-0.263,4.871,0.926,5.041,2.647C483.147,283.479,481.164,285.089,478.552,285.348 M483.782,279.63 c-0.226-0.065-0.374-0.109-0.259-0.403c0.25-0.639,0.276-1.188,0.005-1.581c-0.515-0.734-1.915-0.693-3.521-0.021 c0,0-0.508,0.224-0.378-0.181c0.247-0.798,0.209-1.468-0.178-1.852c-0.87-0.878-3.194,0.032-5.183,2.027 c-1.489,1.494-2.357,3.082-2.357,4.453c0,2.619,3.354,4.213,6.631,4.213c4.297,0,7.154-2.504,7.154-4.493 C485.697,280.594,484.689,279.911,483.782,279.63"/><path d="M486.637,274.833c-1.039-1.154-2.57-1.592-3.982-1.291l0,0c-0.325,0.068-0.532,0.391-0.465,0.72 c0.068,0.328,0.391,0.537,0.72,0.466c1.005-0.215,2.092,0.104,2.827,0.92c0.736,0.818,0.938,1.939,0.625,2.918l0,0 c-0.102,0.318,0.068,0.661,0.39,0.762c0.32,0.104,0.658-0.069,0.763-0.391v-0.001C487.953,277.558,487.674,275.985,486.637,274.833 "/><path d="M485.041,276.276c-0.504-0.562-1.25-0.774-1.938-0.63c-0.279,0.06-0.461,0.339-0.396,0.621 c0.062,0.281,0.335,0.461,0.617,0.398l0,0c0.336-0.071,0.702,0.03,0.947,0.307s0.312,0.649,0.207,0.979l0,0 c-0.089,0.271,0.062,0.565,0.336,0.654c0.274,0.09,0.564-0.062,0.657-0.336C485.686,277.604,485.549,276.837,485.041,276.276"/><path d="M478.694,282.227c-0.09,0.156-0.293,0.233-0.451,0.166c-0.151-0.062-0.204-0.235-0.115-0.389 c0.093-0.155,0.284-0.229,0.44-0.168C478.725,281.892,478.782,282.071,478.694,282.227 M477.862,283.301 c-0.253,0.405-0.795,0.58-1.202,0.396c-0.403-0.186-0.521-0.655-0.27-1.051c0.248-0.39,0.771-0.566,1.176-0.393 C477.979,282.423,478.109,282.889,477.862,283.301 M478.812,280.437c-1.244-0.326-2.65,0.294-3.19,1.396 c-0.553,1.119-0.021,2.369,1.236,2.775c1.303,0.42,2.84-0.225,3.374-1.436C480.758,281.989,480.1,280.77,478.812,280.437"/></g></symbol></svg> </div> <div class="u-vh-full"> <a class="c-skip-link" href="#main-content">Skip to main content</a> <div class="u-hide u-show-following-ad"></div> <aside class="adsbox c-ad c-ad--728x90" data-component-mpu> <div class="c-ad__inner"> <p class="c-ad__label">Advertisement</p> <div id="div-gpt-ad-LB1" data-ad-type="LB1" data-test="LB1-ad" data-pa11y-ignore data-gpt data-gpt-unitpath="/270604982/bmc/biodatamining" data-gpt-sizes="728x90,970x90" data-gpt-targeting="pos=LB1;pmc=L17004,I23050,I18030,L15001,M14018;" > <noscript> <a href="//pubads.g.doubleclick.net/gampad/jump?iu=/270604982/bmc/biodatamining&sz=728x90,970x90&pos=LB1&pmc=L17004,I23050,I18030,L15001,M14018&"> <img data-test="gpt-advert-fallback-img" src="//pubads.g.doubleclick.net/gampad/ad?iu=/270604982/bmc/biodatamining&sz=728x90,970x90&pos=LB1&pmc=L17004,I23050,I18030,L15001,M14018&" alt="Advertisement" width="728" height="90"> </a> </noscript> </div> </div> </aside> <div id="membership-message-loader-desktop" class="placeholder" data-placeholder="/placeholder/v1/membership/message"></div> <div id="top" class="u-position-relative"> <header class="c-header" data-test="publisher-header"> <div class="c-header__container"> <div class="c-header__brand u-mr-48" itemscope itemtype="http://schema.org/Organization" data-test="navbar-logo-header"> <div class="c-logo"> <a href="https://www.biomedcentral.com" itemprop="url"> <img alt="BMC" itemprop="logo" width="76" height="18" role="img" src=/static/images/bmc/logos/logo-bmc-white-aj-be532aa3f0.svg> <div class="c-logo__strapline"> <img alt="Part of Springer Nature" width="173" height="16" role="img" src=/static/images/bmc/logos/logo-bmc-white-strapline-sn-f224388d67.svg> </div> </a> </div> </div> <div class="c-header__navigation"> <button type="button" class="c-header__link u-button-reset u-mr-24" data-expander data-expander-target="#publisher-header-search" data-expander-autofocus="firstTabbable" data-test="header-search-button" aria-controls="publisher-header-search" aria-expanded="false"> <span class="u-display-flex u-align-items-center"> <span>Search</span> <svg class="u-icon u-flex-static u-ml-8" aria-hidden="true" focusable="false"> <use xlink:href="#icon-search"></use> </svg> </span> </button> <nav> <ul class="c-header__menu" data-enhanced-menu data-test="publisher-navigation"> <li class="c-header__item u-hide-at-lt-lg"> <a class="c-header__link" href="//www.biomedcentral.com/journals"> Explore journals </a> </li> <li class="c-header__item u-hide-at-lt-lg"> <a class="c-header__link" href="//www.biomedcentral.com/getpublished"> Get published </a> </li> <li class="c-header__item u-hide-at-lt-lg"> <a class="c-header__link" href="//www.biomedcentral.com/about"> About BMC </a> </li> <li class="c-header__item"> <a data-enhanced-account class="c-header__link" href="https://www.biomedcentral.com/account" data-test="login-link"> My account </a> </li> </ul> </nav> </div> </div> </header> <div class="c-popup-search u-js-hide" id="publisher-header-search"> <div class="u-container"> <div class="c-popup-search__container"> <div class="ctx-search"> <form role="search" class="c-form-field js-skip-validation" method="GET" action="//www.biomedcentral.com/search" data-track="search" data-track-context="pop out website-wide search in bmc website header" data-track-category="Search and Results" data-track-action="Submit search" data-dynamic-track-label data-track-label="" data-test="global-search"> <label for="publisherSearch" class="c-form-field__label">Search all BMC articles</label> <div class="u-display-flex"> <input id="publisherSearch" class="c-form-field__input" data-search-input autocomplete="off" role="textbox" data-test="search-input" name="query" type="text" value=""/> <div> <button class="u-button" type="submit" data-test="search-submit-button"> <span class="u-visually-hidden">Search</span> <svg class="u-icon u-flex-static" width="16" height="16" aria-hidden="true" focusable="false"> <use xlink:href="#icon-search"></use> </svg> </button> </div> </div> <input type="hidden" name="searchType" value="publisherSearch"/> </form> </div> </div> </div> </div> </div> <header class="c-journal-header c-journal-header--biodata-mining ctx-journal-header"> <div class="u-container"> <div class="c-journal-header__inner "> <div class="c-journal-title" id="journalTitle"> <a href="/"> <img class="c-journal-title__logo" src=https://biodatamining.biomedcentral.com/images/13040/logo.svg alt="BioData Mining logo"> <span class="c-journal-title__text ">BioData Mining</span> </a> </div> </div> </div> <div class="c-navbar "> <div class="c-navbar__container"> <div class="c-navbar__content"> <nav class="c-navbar__nav"> <ul class="c-navbar__nav c-navbar__nav--journal" role="menu" data-test="site-navigation"> <li class="c-navbar__item" role="menuitem"> <a class="c-navbar__link" data-track="click" data-track-category="Home" data-track-action="Clicked journal navigation link" href='/'>Home</a> </li> <li class="c-navbar__item" role="menuitem"> <a class="c-navbar__link" data-track="click" data-track-category="About" data-track-action="Clicked journal navigation link" href='/about'>About</a> </li> <li class="c-navbar__item" role="menuitem"> <a class="c-navbar__link c-navbar__link--is-shown" data-track="click" data-track-category="Articles" data-track-action="Clicked journal navigation link" href='/articles'>Articles</a> </li> <li class="c-navbar__item" role="menuitem"> <a class="c-navbar__link" data-track="click" data-track-category="Collections" data-track-action="Clicked journal navigation link" href='/articles/new-content-item'>Collections</a> </li> <li class="c-navbar__item" role="menuitem"> <a class="c-navbar__link" data-track="click" data-track-category="Submission Guidelines" data-track-action="Clicked journal navigation link" href='/submission-guidelines'>Submission Guidelines</a> </li> </ul> </nav> </div> </div> </div> <div class="c-journal-header__identity c-journal-header__identity--midnight-purple"> </div> </header> <div class="u-container u-mt-32 u-mb-32" id="main-content"> <div class="c-page-layout c-page-layout--default" data-component="sticky-container"> <nav class="c-page-layout__nav ctx-sidebar-nav"> <h3 class="c-sidebar-nav__title"><a class="c-sidebar-nav__toggle u-display-inline-flex u-align-items-center" href="#siteNavigationChildren" data-toggle="collapse" data-target="siteNavigationChildren" aria-controls="siteNavigationChildren" aria-expanded="false">Articles</a></h3> <ul id="siteNavigationChildren" class="c-nav c-nav--stacked c-collapse-at-lt-md"> <li class="c-nav__item"> <a class="c-nav__link" href='/reviewer-acknowledgements'> <span class="u-display-flex u-align-items-baseline"> Reviewer acknowledgements </span> </a> </li> <li class="c-nav__item"> <a class="c-nav__link" href='/articles/new-content-item'> <span class="u-display-flex u-align-items-baseline"> Collections </span> </a> </li> </ul> </nav> <main class="c-page-layout__main"> <h1 class="u-mt-0">Articles</h1> <div data-tabs="tabs"> <ul class="c-nav c-nav--tabs u-mb-16" role="tablist"> <li role="presentation" class="c-nav__item"> <a class="c-nav__link is-active" href="/articles?tab=keyword#tab-0" aria-controls="tab-0" role="tab" data-toggle="tab">Search by keyword</a> </li> <li role="presentation" class="c-nav__item"> <a class="c-nav__link" href="/articles?tab=citation#tab-1" aria-controls="tab-1" role="tab" data-toggle="tab">Search by citation</a> </li> </ul> <div role="tabpanel" class="c-tab-content is-active u-mb-16" id="tab-0"> <form role="search" method="GET" action="//biodatamining.biomedcentral.com/articles" class="js-skip-validation" id="keyword-search" data-track="search" data-track-context="keyword search on bmc journal articles listing page" data-form-analytics-enabled="true" data-form-analytics-category="Search and Results" data-form-analytics-action="Submit journal search"> <div class="c-form-field c-form-field--inline"> <input class="c-form-field__input" autocomplete="off" placeholder="Search BioData Mining" role="textbox" id="query" name="query" type="text" value="" title="Search BioData Mining" data-form-analytics-label-component="keyword"/> <label for="volume-from" class="u-visually-hidden">for results from</label> <select name="volume" id="volume-from" class="c-form-field__select" data-form-analytics-label-component="volume"> <option value="">All volumes</option> <option value="17" >Volume 17 (2024)</option> <option value="16" >Volume 16 (2023)</option> <option value="15" >Volume 15 (2022)</option> <option value="14" >Volume 14 (2021)</option> <option value="13" >Volume 13 (2020)</option> <option value="12" >Volume 12 (2019)</option> <option value="11" >Volume 11 (2018)</option> <option value="10" >Volume 10 (2017)</option> <option value="9" >Volume 9 (2016)</option> <option value="8" >Volume 8 (2015)</option> <option value="7" >Volume 7 (2014)</option> <option value="6" >Volume 6 (2013)</option> <option value="5" >Volume 5 (2012)</option> <option value="4" >Volume 4 (2011)</option> <option value="3" >Volume 3 (2010)</option> <option value="2" >Volume 2 (2009)</option> <option value="1" >Volume 1 (2008)</option> </select> </div> <button class="u-button" type="submit">Search</button> <input type=hidden name="searchType" value=""/> <input type=hidden name="tab" value="keyword"/> </form> </div> <div role="tabpanel" class="c-tab-content u-mb-16" id="tab-1"> <form role="search" method="GET" action="//biodatamining.biomedcentral.com/articles" class="js-skip-validation" id="citation-search" data-track="search" data-track-context="citation search on bmc journal articles listing page" data-form-analytics-enabled="true" data-form-analytics-category="Search and Results" data-form-analytics-action="Submit journal search"> <div class="c-form-field c-form-field--inline"> <label for="volume-year" class="u-visually-hidden">Show results from</label> <select name="volume" id="volume-year" class="c-form-field__select" data-form-analytics-label-component="volume"> <option value="">Select a volume</option> <option value="17" >Volume 17 (2024)</option> <option value="16" >Volume 16 (2023)</option> <option value="15" >Volume 15 (2022)</option> <option value="14" >Volume 14 (2021)</option> <option value="13" >Volume 13 (2020)</option> <option value="12" >Volume 12 (2019)</option> <option value="11" >Volume 11 (2018)</option> <option value="10" >Volume 10 (2017)</option> <option value="9" >Volume 9 (2016)</option> <option value="8" >Volume 8 (2015)</option> <option value="7" >Volume 7 (2014)</option> <option value="6" >Volume 6 (2013)</option> <option value="5" >Volume 5 (2012)</option> <option value="4" >Volume 4 (2011)</option> <option value="3" >Volume 3 (2010)</option> <option value="2" >Volume 2 (2009)</option> <option value="1" >Volume 1 (2008)</option> </select> <input class="c-form-field__input" autocomplete="off" placeholder="Article number" role="textbox" id="articleCitationId" name="articleCitationId" type="text" value="" title="Article number" data-form-analytics-label-component="articleNumber"/> </div> <button class="u-button" type="submit">Search</button> <input type="hidden" name="tab" value="citation"/> </form> </div> </div> <div data-total="502" data-test="search-content"> <div class="c-divider c-divider--md"> <div class="u-display-flex u-justify-content-space-between u-flex-wrap u-align-items-center u-mb-16"> <p class="u-text-sm u-reset-margin">Page 1 of 11</p> <form class="c-form-field c-form-field--inline u-float-right u-reset-margin" action="" method="GET" data-component="search-sorter" data-test="sorter"> <input type="hidden" name="tab" value="keyword"> <label class="c-form-field__label" for="sort">Sort by</label> <select class="c-form-field__select" id="sort" name="sort" data-test="search-result-options"> <option data-test="sort-Relevance" value="Relevance">Relevance</option> <option data-test="sort-PubDate" value="PubDate" selected>Newest first</option> <option data-test="sort-PubDateAscending" value="PubDateAscending">Oldest first</option> </select> <button type="submit" class="u-button u-js-hide">Submit</button> </form> </div> </div> <ol class="c-listing" data-test="results-list"> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00404-x" data-track="select_search_result" data-track-context="bmc search results page or article listing">Transcriptome-based network analysis related to regulatory T cells infiltration identified RCN1 as a potential biomarker for prognosis in clear cell renal cell carcinoma</a> </h3> <p> Regulatory T cells (Tregs) play a critical role in shaping the immunosuppressive microenvironment within tumors. Investigating the role of Tregs in Clear cell renal cell carcinoma (ccRCC) is crucial for identi... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Yang Qixin, Huang Jing, He Jiang, Liu Xueyang, Yu Lu and Li Yuehua</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:51 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">14 November 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00404-x" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00404-x" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00404-x" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00404-x.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00400-1" data-track="select_search_result" data-track-context="bmc search results page or article listing">Deciphering the tissue-specific functional effect of Alzheimer risk SNPs with deep genome annotation</a> </h3> <p> Alzheimer’s disease (AD) is a highly heritable brain dementia, along with substantial failure of cognitive function. Large-scale genome-wide association studies (GWASs) have led to a set of SNPs significantly ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Pradeep Varathan Pugalenthi, Bing He, Linhui Xie, Kwangsik Nho, Andrew J. Saykin and Jingwen Yan</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:50 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">13 November 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00400-1" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00400-1" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00400-1" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00400-1.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00405-w" data-track="select_search_result" data-track-context="bmc search results page or article listing">Investigating potential drug targets for IgA nephropathy and membranous nephropathy through multi-queue plasma protein analysis: a Mendelian randomization study based on SMR and co-localization analysis</a> </h3> <p> Membranous nephropathy (MN) and IgA nephropathy (IgAN) pose challenges in clinical treatment with existing therapies primarily focusing on symptom relief and often yielding unsatisfactory outcomes. The search ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Xinyi Xu, Changhong Miao, Shirui Yang, Lu Xiao, Ying Gao, Fangying Wu and Jianbo Xu</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:49 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">8 November 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00405-w" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00405-w" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00405-w" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00405-w.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00395-9" data-track="select_search_result" data-track-context="bmc search results page or article listing">Deep joint learning diagnosis of Alzheimer’s disease based on multimodal feature fusion</a> </h3> <p> Alzheimer’s disease (AD) is an advanced and incurable neurodegenerative disease. Genetic variations are intrinsic etiological factors contributing to the abnormal expression of brain function and structure in ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Jingru Wang, Shipeng Wen, Wenjie Liu, Xianglian Meng and Zhuqing Jiao</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:48 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">5 November 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00395-9" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00395-9" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00395-9" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00395-9.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00403-y" data-track="select_search_result" data-track-context="bmc search results page or article listing">Modeling heterogeneity of Sudanese hospital stay in neonatal and maternal unit: non-parametric random effect models with Gamma distribution</a> </h3> <p> Studies looking into patient and institutional variables linked to extended hospital stays have arisen as a result of the increased focus on severe maternal morbidity and mortality. Understanding the length of... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Amani Almohaimeed and Ishag Adam</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:47 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">1 November 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00403-y" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00403-y" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00403-y" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00403-y.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00397-7" data-track="select_search_result" data-track-context="bmc search results page or article listing">Ensemble feature selection and tabular data augmentation with generative adversarial networks to enhance cutaneous melanoma identification and interpretability</a> </h3> <p> Cutaneous melanoma is the most aggressive form of skin cancer, responsible for most skin cancer-related deaths. Recent advances in artificial intelligence, jointly with the availability of public dermoscopy im... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Vanesa Gómez-Martínez, David Chushig-Muzo, Marit B. Veierød, Conceição Granja and Cristina Soguero-Ruiz</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:46 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">30 October 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00397-7" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00397-7" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00397-7" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00397-7.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00401-0" data-track="select_search_result" data-track-context="bmc search results page or article listing">Priority-Elastic net for binary disease outcome prediction based on multi-omics data</a> </h3> <p> High-dimensional omics data integration has emerged as a prominent avenue within the healthcare industry, presenting substantial potential to improve predictive models. However, the data integration process fa... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Laila Musib, Roberta Coletti, Marta B. Lopes, Helena Mouriño and Eunice Carrasquinha</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:45 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Methodology</span> <span data-test="published-on">Published on: <span itemprop="datePublished">29 October 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00401-0" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00401-0" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00401-0" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00401-0.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00398-6" data-track="select_search_result" data-track-context="bmc search results page or article listing">A regularized Cox hierarchical model for incorporating annotation information in predictive omic studies</a> </h3> <p> Associated with high-dimensional omics data there are often “meta-features” such as biological pathways and functional annotations, summary statistics from similar studies that can be informative for predictin... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Dixin Shen, Juan Pablo Lewinger and Eric Kawaguchi</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:44 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Methodology</span> <span data-test="published-on">Published on: <span itemprop="datePublished">24 October 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00398-6" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00398-6" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00398-6" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00398-6.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00402-z" data-track="select_search_result" data-track-context="bmc search results page or article listing">G4 & the balanced metric family – a novel approach to solving binary classification problems in medical device validation & verification studies</a> </h3> <p> In medical device validation and verification studies, the area under the receiver operating characteristic curve (AUROC) is often used as a primary endpoint despite multiple reports showing its limitations. H... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Andrew Marra</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:43 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Methodology</span> <span data-test="published-on">Published on: <span itemprop="datePublished">23 October 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00402-z" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00402-z" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00402-z" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00402-z.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00396-8" data-track="select_search_result" data-track-context="bmc search results page or article listing">From COVID-19 to monkeypox: a novel predictive model for emerging infectious diseases</a> </h3> <p> The outbreak of emerging infectious diseases poses significant challenges to global public health. Accurate early forecasting is crucial for effective resource allocation and emergency response planning. This ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Deren Xu, Weng Howe Chan, Habibollah Haron, Hui Wen Nies and Kohbalan Moorthy</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:42 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">22 October 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00396-8" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00396-8" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00396-8" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00396-8.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00393-x" data-track="select_search_result" data-track-context="bmc search results page or article listing">PAGER: A novel genotype encoding strategy for modeling deviations from additivity in complex trait association studies</a> </h3> <p> The additive model of inheritance assumes that heterozygotes (Aa) are exactly intermediate in respect to homozygotes (AA and aa). While this model is commonly used in single-locus genetic association studies, ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Philip J. Freda, Attri Ghosh, Priyanka Bhandary, Nicholas Matsumoto, Apurva S. Chitre, Jiayan Zhou, Molly A. Hall, Abraham A. Palmer, Tayo Obafemi-Ajayi and Jason H. Moore</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:41 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">11 October 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00393-x" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00393-x" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00393-x" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00393-x.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00394-w" data-track="select_search_result" data-track-context="bmc search results page or article listing">Decoding the genetic comorbidity network of Alzheimer's disease</a> </h3> <p> Alzheimer's disease (AD) has emerged as the most prevalent and complex neurodegenerative disorder among the elderly population. However, the genetic comorbidity etiology for AD remains poorly understood. In th... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Xueli Zhang, Dantong Li, Siting Ye, Shunming Liu, Shuo Ma, Min Li, Qiliang Peng, Lianting Hu, Xianwen Shang, Mingguang He and Lei Zhang</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:40 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">9 October 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00394-w" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00394-w" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00394-w" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00394-w.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> <div class="c-listing__graphical-abstract u-mt-16"> <img src="https://static-content.springer.com/image/art%3A10.1186%2Fs13040-024-00394-w/MediaObjects/13040_2024_394_Figa_HTML.png" alt=""> </div> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00392-y" data-track="select_search_result" data-track-context="bmc search results page or article listing">MDVarP: modifier ~ disease-causing variant pairs predictor</a> </h3> <p> Modifiers significantly impact disease phenotypes by modulating the effects of disease-causing variants, resulting in varying disease manifestations among individuals. However, identifying genetic interactions... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Hong Sun, Yunqin Chen and Liangxiao Ma</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:39 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">8 October 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00392-y" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00392-y" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00392-y" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00392-y.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00391-z" data-track="select_search_result" data-track-context="bmc search results page or article listing">Deep learning-based approaches for multi-omics data integration and analysis</a> </h3> <p> The rapid growth of deep learning, as well as the vast and ever-growing amount of available data, have provided ample opportunity for advances in fusion and analysis of complex and heterogeneous data types. Di... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Jenna L. Ballard, Zexuan Wang, Wenrui Li, Li Shen and Qi Long</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:38 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Review</span> <span data-test="published-on">Published on: <span itemprop="datePublished">2 October 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00391-z" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00391-z" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00391-z" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00391-z.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00390-0" data-track="select_search_result" data-track-context="bmc search results page or article listing">Assessing the limitations of relief-based algorithms in detecting higher-order interactions</a> </h3> <p> Epistasis, the interaction between genetic loci where the effect of one locus is influenced by one or more other loci, plays a crucial role in the genetic architecture of complex traits. However, as the number... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Philip J. Freda, Suyu Ye, Robert Zhang, Jason H. Moore and Ryan J. Urbanowicz</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:37 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">1 October 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00390-0" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00390-0" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00390-0" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00390-0.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00389-7" data-track="select_search_result" data-track-context="bmc search results page or article listing">Identifying heterogeneous subgroups of systemic autoimmune diseases by applying a joint dimension reduction and clustering approach to immunomarkers</a> </h3> <p> The high complexity of systemic autoimmune diseases (SADs) has hindered precise management. This study aims to investigate heterogeneity in SADs. </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Chia-Wei Chang, Hsin-Yao Wang, Wan-Ying Lin, Yu-Chiang Wang, Wei-Lin Lo, Ting-Wei Lin, Jia-Ruei Yu and Yi-Ju Tseng</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:36 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">16 September 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00389-7" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00389-7" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00389-7" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00389-7.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00387-9" data-track="select_search_result" data-track-context="bmc search results page or article listing">Development, evaluation and comparison of machine learning algorithms for predicting in-hospital patient charges for congestive heart failure exacerbations, chronic obstructive pulmonary disease exacerbations and diabetic ketoacidosis</a> </h3> <p> Hospitalizations for exacerbations of congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) and diabetic ketoacidosis (DKA) are costly in the United States. The purpose of this study was... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Monique Arnold, Lathan Liou and Mary Regina Boland</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:35 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">12 September 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00387-9" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00387-9" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00387-9" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00387-9.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00388-8" data-track="select_search_result" data-track-context="bmc search results page or article listing">Knowledge-slanted random forest method for high-dimensional data and small sample size with a feature selection application for gene expression data</a> </h3> <p> The use of prior knowledge in the machine learning framework has been considered a potential tool to handle the curse of dimensionality in genetic and genomics data. Although random forest (RF) represents a fl... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Erika Cantor, Sandra Guauque-Olarte, Roberto León, Steren Chabert and Rodrigo Salas</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:34 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">10 September 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00388-8" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00388-8" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00388-8" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00388-8.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00379-9" data-track="select_search_result" data-track-context="bmc search results page or article listing">Private pathological assessment via machine learning and homomorphic encryption</a> </h3> <p> The objective of this research is to explore the applicability of machine learning and fully homomorphic encryption (FHE) in the private pathological assessment, with a focus on the inference phase of support ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Ahmad Al Badawi and Mohd Faizal Bin Yusof</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:33 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">10 September 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00379-9" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00379-9" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00379-9" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00379-9.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00383-z" data-track="select_search_result" data-track-context="bmc search results page or article listing">Enhanced labor pain monitoring using machine learning and ECG waveform analysis for uterine contraction-induced pain</a> </h3> <p> This study aims to develop an innovative approach for monitoring and assessing labor pain through ECG waveform analysis, utilizing machine learning techniques to monitor pain resulting from uterine contractions. </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Yuan-Chia Chu, Saint Shiou-Sheng Chen, Kuen-Bao Chen, Jui-Sheng Sun, Tzu-Kuei Shen and Li-Kuei Chen</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:32 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">7 September 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00383-z" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00383-z" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00383-z" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00383-z.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00385-x" data-track="select_search_result" data-track-context="bmc search results page or article listing">The goldmine of GWAS summary statistics: a systematic review of methods and tools</a> </h3> <p> Genome-wide association studies (GWAS) have revolutionized our understanding of the genetic architecture of complex traits and diseases. GWAS summary statistics have become essential tools for various genetic ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Panagiota I. Kontou and Pantelis G. Bagos</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:31 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">5 September 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00385-x" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00385-x" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00385-x" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00385-x.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00386-w" data-track="select_search_result" data-track-context="bmc search results page or article listing">QIGTD: identifying critical genes in the evolution of lung adenocarcinoma with tensor decomposition</a> </h3> <p> Identifying critical genes is important for understanding the pathogenesis of complex diseases. Traditional studies typically comparing the change of biomecules between normal and disease samples or detecting ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Bolin Chen, Jinlei Zhang, Ci Shao, Jun Bian, Ruiming Kang and Xuequn Shang</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:30 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">4 September 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00386-w" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00386-w" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00386-w" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00386-w.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00384-y" data-track="select_search_result" data-track-context="bmc search results page or article listing">Processing imbalanced medical data at the data level with assisted-reproduction data as an example</a> </h3> <p> Data imbalance is a pervasive issue in medical data mining, often leading to biased and unreliable predictive models. This study aims to address the urgent need for effective strategies to mitigate the impact ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Junliang Zhu, Shaowei Pu, Jiaji He, Dongchao Su, Weijie Cai, Xueying Xu and Hongbo Liu</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:29 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">4 September 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00384-y" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00384-y" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00384-y" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00384-y.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00380-2" data-track="select_search_result" data-track-context="bmc search results page or article listing">Seven quick tips for gene-focused computational pangenomic analysis</a> </h3> <p> Pangenomics is a relatively new scientific field which investigates the union of all the genomes of a clade. The word <em>pan</em> means <em>everything</em> in ancient Greek; the term pangenomics originally regarded genomes of bac... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Vincenzo Bonnici and Davide Chicco</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:28 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Brief Report</span> <span data-test="published-on">Published on: <span itemprop="datePublished">3 September 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00380-2" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00380-2" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00380-2" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00380-2.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00381-1" data-track="select_search_result" data-track-context="bmc search results page or article listing">Deep learning for automatic calcium detection in echocardiography</a> </h3> <p> Cardiovascular diseases are the main cause of death in the world and cardiovascular imaging techniques are the mainstay of noninvasive diagnosis. Aortic stenosis is a lethal cardiac disease preceded by aortic ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Luís B. Elvas, Sara Gomes, João C. Ferreira, Luís Brás Rosário and Tomás Brandão</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:27 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">28 August 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00381-1" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00381-1" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00381-1" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00381-1.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00382-0" data-track="select_search_result" data-track-context="bmc search results page or article listing">Integrating transcriptomics and proteomics to analyze the immune microenvironment of cytomegalovirus associated ulcerative colitis and identify relevant biomarkers</a> </h3> <p> In recent years, significant morbidity and mortality in patients with severe inflammatory bowel disease (IBD) and cytomegalovirus (CMV) have drawn considerable attention to the status of CMV infection in the i... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Yang Chen, Qingqing Zheng, Hui Wang, Peiren Tang, Li Deng, Pu Li, Huan Li, Jianhong Hou, Jie Li, Li Wang and Jun Peng</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:26 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">27 August 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00382-0" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00382-0" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00382-0" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00382-0.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00378-w" data-track="select_search_result" data-track-context="bmc search results page or article listing">Understanding predictions of drug profiles using explainable machine learning models</a> </h3> <p> The analysis of absorption, distribution, metabolism, and excretion (ADME) molecular properties is of relevance to drug design, as they directly influence the drug’s effectiveness at its target location. This ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Caroline König and Alfredo Vellido</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:25 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">1 August 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00378-w" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00378-w" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00378-w" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00378-w.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00375-z" data-track="select_search_result" data-track-context="bmc search results page or article listing">Modelling the nicotine pharmacokinetic profile for e-cigarettes using real time monitoring of consumers’ physiological measurements and mouth level exposure</a> </h3> <p> Pharmacokinetic (PK) studies can provide essential information on abuse liability of nicotine and tobacco products but are intrusive and must be conducted in a clinical environment. The objective of the study ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Krishna Prasad, Allen Griffiths, Kavya Agrawal, Michael McEwan, Flavio Macci, Marco Ghisoni, Matthew Stopher, Matthew Napleton, Joel Strickland, David Keating, Thomas Whitehead, Gareth Conduit, Stacey Murray and Lauren Edward</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:24 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">17 July 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00375-z" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00375-z" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00375-z" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00375-z.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00376-y" data-track="select_search_result" data-track-context="bmc search results page or article listing">Construction and application of medication reminder system: intelligent generation of universal medication schedule</a> </h3> <p> Patients with chronic conditions need multiple medications daily to manage their condition. However, most patients have poor compliance, which affects the effectiveness of treatment. To address these challenge... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Hangxing Huang, Lu Zhang, Yongyu Yang, Ling Huang, Xikui Lu, Jingyang Li, Huimin Yu, Shuqiao Cheng and Jian Xiao</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:23 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">15 July 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00376-y" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00376-y" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00376-y" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00376-y.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00373-1" data-track="select_search_result" data-track-context="bmc search results page or article listing">Building RadiologyNET: an unsupervised approach to annotating a large-scale multimodal medical database</a> </h3> <p> The use of machine learning in medical diagnosis and treatment has grown significantly in recent years with the development of computer-aided diagnosis systems, often based on annotated medical radiology image... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Mateja Napravnik, Franko Hržić, Sebastian Tschauner and Ivan Štajduhar</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:22 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">12 July 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00373-1" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00373-1" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00373-1" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00373-1.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00374-0" data-track="select_search_result" data-track-context="bmc search results page or article listing">Transcriptome- and DNA methylation-based cell-type deconvolutions produce similar estimates of differential gene expression and differential methylation</a> </h3> <p> Changing cell-type proportions can confound studies of differential gene expression or DNA methylation (DNAm) from peripheral blood mononuclear cells (PBMCs). We examined how cell-type proportions derived from... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Emily R. Hannon, Carmen J. Marsit, Arlene E. Dent, Paula Embury, Sidney Ogolla, David Midem, Scott M. Williams and James W. Kazura</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:21 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">11 July 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00374-0" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00374-0" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00374-0" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00374-0.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00369-x" data-track="select_search_result" data-track-context="bmc search results page or article listing">Identification of immune-associated biomarkers of diabetes nephropathy tubulointerstitial injury based on machine learning: a bioinformatics multi-chip integrated analysis</a> </h3> <p> Diabetic nephropathy (DN) is a major microvascular complication of diabetes and has become the leading cause of end-stage renal disease worldwide. A considerable number of DN patients have experienced irrevers... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Lin Wang, Jiaming Su, Zhongjie Liu, Shaowei Ding, Yaotan Li, Baoluo Hou, Yuxin Hu, Zhaoxi Dong, Jingyi Tang, Hongfang Liu and Weijing Liu</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:20 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">1 July 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00369-x" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00369-x" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00369-x" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00369-x.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00372-2" data-track="select_search_result" data-track-context="bmc search results page or article listing">Electronic medical records imputation by temporal Generative Adversarial Network</a> </h3> <p> The loss of electronic medical records has seriously affected the practical application of biomedical data. Therefore, it is a meaningful research effort to effectively fill these lost data. Currently, state-o... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Yunfei Yin, Zheng Yuan, Islam Md Tanvir and Xianjian Bao</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:19 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">26 June 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00372-2" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00372-2" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00372-2" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00372-2.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00370-4" data-track="select_search_result" data-track-context="bmc search results page or article listing">Saliency-driven explainable deep learning in medical imaging: bridging visual explainability and statistical quantitative analysis</a> </h3> <p> Deep learning shows great promise for medical image analysis but often lacks explainability, hindering its adoption in healthcare. Attribution techniques that explain model reasoning can potentially increase t... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Yusuf Brima and Marcellin Atemkeng</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:18 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">22 June 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00370-4" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00370-4" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00370-4" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00370-4.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00367-z" data-track="select_search_result" data-track-context="bmc search results page or article listing">Minimization of occurrence of retained surgical items using machine learning and deep learning techniques: a review</a> </h3> <p> Retained surgical items (RSIs) pose significant risks to patients and healthcare professionals, prompting extensive efforts to reduce their incidence. RSIs are objects inadvertently left within patients’ bodie... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Mohammed Abo-Zahhad, Ahmed H. Abd El-Malek, Mohammed S. Sayed and Susan Njeri Gitau</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:17 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Review</span> <span data-test="published-on">Published on: <span itemprop="datePublished">18 June 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00367-z" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00367-z" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00367-z" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00367-z.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00371-3" data-track="select_search_result" data-track-context="bmc search results page or article listing">Using GPT-4 to write a scientific review article: a pilot evaluation study</a> </h3> <p> GPT-4, as the most advanced version of OpenAI’s large language models, has attracted widespread attention, rapidly becoming an indispensable AI tool across various areas. This includes its exploration by scien... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Zhiping Paul Wang, Priyanka Bhandary, Yizhou Wang and Jason H. Moore</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:16 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">18 June 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00371-3" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00371-3" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00371-3" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00371-3.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00368-y" data-track="select_search_result" data-track-context="bmc search results page or article listing">Unveiling wearables: exploring the global landscape of biometric applications and vital signs and behavioral impact</a> </h3> <p> The development of neuroscientific techniques enabling the recording of brain and peripheral nervous system activity has fueled research in cognitive science. Recent technological advancements offer new possib... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Carolina Del-Valle-Soto, Ramon A. Briseño, Leonardo J. Valdivia and Juan Arturo Nolazco-Flores</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:15 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">11 June 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00368-y" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00368-y" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00368-y" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00368-y.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00366-0" data-track="select_search_result" data-track-context="bmc search results page or article listing">A machine learning approach using conditional normalizing flow to address extreme class imbalance problems in personal health records</a> </h3> <p> Supervised machine learning models have been widely used to predict and get insight into diseases by classifying patients based on personal health records. However, a class imbalance is an obstacle that disrup... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Yeongmin Kim, Wongyung Choi, Woojeong Choi, Grace Ko, Seonggyun Han, Hwan-Cheol Kim, Dokyoon Kim, Dong-gi Lee, Dong Wook Shin and Younghee Lee</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:14 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">25 May 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00366-0" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00366-0" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00366-0" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00366-0.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00365-1" data-track="select_search_result" data-track-context="bmc search results page or article listing">The biomedical knowledge graph of symptom phenotype in coronary artery plaque: machine learning-based analysis of real-world clinical data</a> </h3> <p> A knowledge graph can effectively showcase the essential characteristics of data and is increasingly emerging as a significant means of integrating information in the field of artificial intelligence. Coronary... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Jia-Ming Huan, Xiao-Jie Wang, Yuan Li, Shi-Jun Zhang, Yuan-Long Hu and Yun-Lun Li</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:13 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">21 May 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00365-1" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00365-1" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00365-1" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00365-1.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00363-3" data-track="select_search_result" data-track-context="bmc search results page or article listing">Machine-learning-based models to predict cardiovascular risk using oculomics and clinic variables in KNHANES</a> </h3> <p> Recent researches have found a strong correlation between the triglyceride-glucose (TyG) index or the atherogenic index of plasma (AIP) and cardiovascular disease (CVD) risk. However, there is a lack of resear... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Yuqi Zhang, Sijin Li, Weijie Wu, Yanqing Zhao, Jintao Han, Chao Tong, Niansang Luo and Kun Zhang</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:12 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">22 April 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00363-3" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00363-3" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00363-3" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00363-3.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00362-4" data-track="select_search_result" data-track-context="bmc search results page or article listing">Decoding dynamic miRNA:ceRNA interactions unveils therapeutic insights and targets across predominant cancer landscapes</a> </h3> <p> Competing endogenous RNAs play key roles in cellular molecular mechanisms through cross-talk in post-transcriptional interactions. Studies on ceRNA cross-talk, which is particularly dependent on the abundance ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Selcen Ari Yuka and Alper Yilmaz</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:11 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">17 April 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00362-4" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00362-4" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00362-4" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00362-4.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00361-5" data-track="select_search_result" data-track-context="bmc search results page or article listing">Evaluation of network-guided random forest for disease gene discovery</a> </h3> <p> Gene network information is believed to be beneficial for disease module and pathway identification, but has not been explicitly utilized in the standard random forest (RF) algorithm for gene expression data a... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Jianchang Hu and Silke Szymczak</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:10 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">16 April 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00361-5" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00361-5" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00361-5" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00361-5.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00360-6" data-track="select_search_result" data-track-context="bmc search results page or article listing">MOCAT: multi-omics integration with auxiliary classifiers enhanced autoencoder</a> </h3> <p> Integrating multi-omics data is emerging as a critical approach in enhancing our understanding of complex diseases. Innovative computational methods capable of managing high-dimensional and heterogeneous datas... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Xiaohui Yao, Xiaohan Jiang, Haoran Luo, Hong Liang, Xiufen Ye, Yanhui Wei and Shan Cong</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:9 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">5 March 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00360-6" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00360-6" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00360-6" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00360-6.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00359-z" data-track="select_search_result" data-track-context="bmc search results page or article listing">Interpreting drug synergy in breast cancer with deep learning using target-protein inhibition profiles</a> </h3> <p> Breast cancer is the most common malignancy among women worldwide. Despite advances in treating breast cancer over the past decades, drug resistance and adverse effects remain challenging. Recent therapeutic p... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Thanyawee Srithanyarat, Kittisak Taoma, Thana Sutthibutpong, Marasri Ruengjitchatchawalya, Monrudee Liangruksa and Teeraphan Laomettachit</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:8 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">29 February 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00359-z" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00359-z" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00359-z" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00359-z.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00358-0" data-track="select_search_result" data-track-context="bmc search results page or article listing">Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis</a> </h3> <p> Epistasis, the interaction between two or more genes, is integral to the study of genetics and is present throughout nature. Yet, it is seldom fully explored as most approaches primarily focus on single-locus ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Sandra Batista, Vered Senderovich Madar, Philip J. Freda, Priyanka Bhandary, Attri Ghosh, Nicholas Matsumoto, Apurva S. Chitre, Abraham A. Palmer and Jason H. Moore</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:7 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Methodology</span> <span data-test="published-on">Published on: <span itemprop="datePublished">28 February 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00358-0" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00358-0" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00358-0" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00358-0.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00356-2" data-track="select_search_result" data-track-context="bmc search results page or article listing">Assessment of the causal relationship between gut microbiota and cardiovascular diseases: a bidirectional Mendelian randomization analysis</a> </h3> <p> Previous studies have shown an association between gut microbiota and cardiovascular diseases (CVDs). However, the underlying causal relationship remains unclear. This study aims to elucidate the causal relati... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Xiao-Ce Dai, Yi Yu, Si-Yu Zhou, Shuo Yu, Mei-Xiang Xiang and Hong Ma</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:6 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">26 February 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00356-2" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00356-2" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00356-2" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00356-2.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00357-1" data-track="select_search_result" data-track-context="bmc search results page or article listing">A network-based drug prioritization and combination analysis for the MEK5/ERK5 pathway in breast cancer</a> </h3> <p> Prioritizing candidate drugs based on genome-wide expression data is an emerging approach in systems pharmacology due to its holistic perspective for preclinical drug evaluation. In the current study, a networ... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Regan Odongo, Asuman Demiroglu-Zergeroglu and Tunahan Çakır</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:5 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">21 February 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00357-1" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00357-1" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00357-1" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00357-1.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-023-00353-x" data-track="select_search_result" data-track-context="bmc search results page or article listing">m1A-Ensem: accurate identification of 1-methyladenosine sites through ensemble models</a> </h3> <p> 1-methyladenosine (m1A) is a variant of methyladenosine that holds a methyl substituent in the 1st position having a prominent role in RNA stability and human metabolites. </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Muhammad Taseer Suleman, Fahad Alturise, Tamim Alkhalifah and Yaser Daanial Khan</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:4 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">15 February 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-023-00353-x" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-023-00353-x" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-023-00353-x" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-023-00353-x.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item u-keyline"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00355-3" data-track="select_search_result" data-track-context="bmc search results page or article listing">Revealing third-order interactions through the integration of machine learning and entropy methods in genomic studies</a> </h3> <p> Non-linear relationships at the genotype level are essential in understanding the genetic interactions of complex disease traits. Genome-wide association Studies (GWAS) have revealed statistical association of... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">Burcu Yaldız, Onur Erdoğan, Sevda Rafatov, Cem Iyigün and Yeşim Aydın Son</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:3 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">30 January 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00355-3" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00355-3" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00355-3" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00355-3.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> <li class="c-listing__item"> <article class="c-listing__content u-mb-16" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title" itemprop="name"> <a itemprop="url" data-test="title-link" href="/articles/10.1186/s13040-024-00354-4" data-track="select_search_result" data-track-context="bmc search results page or article listing">Antibody selection strategies and their impact in predicting clinical malaria based on multi-sera data</a> </h3> <p> Nowadays, the chance of discovering the best antibody candidates for predicting clinical malaria has notably increased due to the availability of multi-sera data. The analysis of these data is typically divide... </p> <div class="c-listing__authors u-mb-0" data-test="ResultList-authors"> <span class="u-visually-hidden">Authors: </span> <span class="c-listing__authors-list">André Fonseca, Mikolaj Spytek, Przemysław Biecek, Clara Cordeiro and Nuno Sepúlveda</span> </div> <div data-test="teaser-citation"> <span class="u-visually-hidden">Citation:</span> <em data-test="journal-title">BioData Mining</em> 2024 <span>17</span>:2 </div> <div class="c-listing__metadata"> <span data-test="result-list"><span class="u-visually-hidden">Content type: </span>Research</span> <span data-test="published-on">Published on: <span itemprop="datePublished">25 January 2024</span></span> </div> <ul class="c-listing__view-options" data-test="article-list-search-results"> <li> <a href="/articles/10.1186/s13040-024-00354-4" data-track="select_search_result" data-track-category="Article List" data-track-action="Click Fulltext" data-test="fulltext-link" data-track-label="10.1186/s13040-024-00354-4" itemprop="citation"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> Full Text </span> </a> </li> <li> <a data-track="content_download" data-track-context="article listing link" data-track-type="article pdf download" data-track-category="Article List" data-track-action="Download PDF" data-track-label="10.1186/s13040-024-00354-4" data-test="pdf-link" href="/counter/pdf/10.1186/s13040-024-00354-4.pdf"> <svg class="c-listing__view-options-icon" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> <span> <span class="u-visually-hidden">View </span> PDF </span> </a> </li> </ul> </article> </li> </ol> <nav aria-label="pagination" class="u-display-flex u-justify-content-center u-mt-24 u-mb-24" data-test="pagination"> <ul class="c-pagination"> <li class="c-pagination__item"> <span class="c-pagination__link c-pagination__link--disabled" data-test="previous-page-disabled"> <span class="u-display-flex u-align-items-center"> <svg class="u-flex-static u-mr-8 c-pagination__icon" aria-hidden="true" focusable="false"> <use xlink:href="#icon-springer-arrow-left"></use> </svg> <span>Previous<span class="u-visually-hidden"> page</span></span> </span> </span> </li> <li class="c-pagination__item" data-page="1"> <span class="c-pagination__link c-pagination__link--active">1</span> </li> <li class="c-pagination__item" data-page="2"> <a href="/articles?searchType=journalSearch&sort=PubDate&page=2" class="c-pagination__link"> 2 </a> </li> <li class="c-pagination__item" data-page="3"> <a href="/articles?searchType=journalSearch&sort=PubDate&page=3" class="c-pagination__link"> 3 </a> </li> <li class="c-pagination__item" data-page="4"> <a href="/articles?searchType=journalSearch&sort=PubDate&page=4" class="c-pagination__link"> 4 </a> </li> <li class="c-pagination__item" data-page="5"> <a href="/articles?searchType=journalSearch&sort=PubDate&page=5" class="c-pagination__link"> 5 </a> </li> <li class="c-pagination__item"> <span class="c-pagination--ellipsis">…</span> </li> <li class="c-pagination__item" data-page="11"> <a href="/articles?searchType=journalSearch&sort=PubDate&page=11" class="c-pagination__link"> 11 </a> </li> <li class="c-pagination__item"> <a href="/articles?searchType=journalSearch&sort=PubDate&page=2" rel="next" class="c-pagination__link" data-test="next-page"> <span class="u-display-flex u-align-items-center"> <span>Next<span class="u-visually-hidden"> page</span></span> <svg class="u-flex-static u-ml-8 c-pagination__icon c-pagination__icon--active" aria-hidden="true" focusable="false"> <use xlink:href="#icon-springer-arrow-right"></use> </svg> </span> </a> </li> </ul> </nav> <aside data-test="survey" class="u-hide u-js-show c-customer-satisfaction-input" data-customer-satisfaction-input="" data-customer-satisfaction-input-user-journeys="discover relevant scholarly content" data-customer-satisfaction-input-additional-info="bmc test"> <div class="c-customer-satisfaction-input__container"> <form class="c-customer-satisfaction-input__form js-skip-validation"> <h3 class="c-customer-satisfaction-input__heading">How was your experience today?</h3> <div class="c-forms__fieldset"> <div class="c-forms__field c-forms__field--globalFormRadios"> <fieldset class="c-forms__fieldset c-forms__field c-forms__radios" id="customer-satisfaction-input-radios" name="customer-satisfaction-input-radios" invalid="" aria-invalid="true" aria-describedby="error-customer-satisfaction-input-radios" required="" aria-required="true" autocomplete="off"> <legend class="c-forms__label">Rating<span class="c-form__label--visually-hidden">. A scale of 5 feelings conveyed using images that range from awful to great. The feelings represent how you feel about your experience today.</span></legend> <small class="c-forms__error" id="error-customer-satisfaction-input-radios"> <span class="c-forms__icon c-forms__icon--error"> <svg class="u-icon u-mr-4" width="22" height="22" aria-hidden="true" focusable="false"> <svg id="i-error" viewBox="0 0 18 18" xmlns="http://www.w3.org/2000/svg"><path d="m9 0c4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9zm2.8630343 4.71100931-2.8630343 2.86303426-2.86303426-2.86303426c-.39658757-.39658757-1.03281091-.39438847-1.4265779-.00062147-.39651227.39651226-.39348876 1.03246767.00062147 1.4265779l2.86303426 2.86303426-2.86303426 2.8630343c-.39658757.3965875-.39438847 1.0328109-.00062147 1.4265779.39651226.3965122 1.03246767.3934887 1.4265779-.0006215l2.86303426-2.8630343 2.8630343 2.8630343c.3965875.3965876 1.0328109.3943885 1.4265779.0006215.3965122-.3965123.3934887-1.0324677-.0006215-1.4265779l-2.8630343-2.8630343 2.8630343-2.86303426c.3965876-.39658757.3943885-1.03281091.0006215-1.4265779-.3965123-.39651227-1.0324677-.39348876-1.4265779.00062147z" fill="currentColor" fill-rule="evenodd"></path></svg> </svg> </span> Please select one rating </small> <div class="c-forms__pictographic-radios"> <div class="c-forms__label c-forms__label--wrapper"> <input class="c-forms__input c-forms__input--radio" type="radio" id="radio-awful" name="customer-satisfaction-input-radios" value="1" required="" aria-required="true" autocomplete="off" data-customer-satisfaction-input="radio"> <label for="radio-awful" class="c-forms__label c-forms__label--pictographic-radio c-forms__label--boxed-icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" fill="transparent" stroke="currentColor" aria-hidden="true" focusable="false"> <clipPath id="a"> <path d="M24 0v24H0V0z"></path> </clipPath> <g stroke-width="1.8" clip-path="url(#a)"> <path d="M12 22c5.5228475 0 10-4.4771525 10-10S17.5228475 2 12 2 2 6.4771525 2 12s4.4771525 10 10 10z" stroke-miterlimit="10"></path> <g stroke-linecap="round"> <path d="M8 17c.5-5.33333333 7.5-5.33333333 8 0z" stroke-linejoin="round"></path> <path d="m9 9-2 1M17 10l-2-1" stroke-miterlimit="10"></path> </g> </g></svg> <span class="c-form__label--visually-hidden">An image of a cartoon face that is very unhappy.</span> <span><span class="c-form__label--visually-hidden"> The value of this radio input is: </span>Awful</span> </label> </div> <div class="c-forms__label c-forms__label--wrapper"> <input class="c-forms__input c-forms__input--radio" type="radio" id="radio-bad" name="customer-satisfaction-input-radios" value="2" required="" aria-required="true" autocomplete="off" data-customer-satisfaction-input="radio"> <label for="radio-bad" class="c-forms__label c-forms__label--pictographic-radio c-forms__label--boxed-icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="transparent" stroke="currentColor" aria-hidden="true" focusable="false" viewBox="0 0 24 24"> <defs> <clipPath id="frowna"> <path d="M24 0v24H0V0h24Z"></path> </clipPath> <clipPath id="frownb"> <path d="M1 0c.6 0 1 .4 1 1v2a1 1 0 1 1-2 0V1c0-.6.4-1 1-1Z"></path> </clipPath> </defs> <g clip-path="url(#frowna)"> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="1.8" stroke-linejoin="round" d="M12 22a10 10 0 1 0 0-20 10 10 0 0 0 0 20Z"></path> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="1.8" stroke-linejoin="round" d="M9 17c1-2.7 5-2.7 6 0"></path> <g clip-path="url(#frownb)" transform="translate(8 8)"> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="2" stroke-linejoin="round" d="M0 0h2v4H0V0z"></path> </g> <g clip-path="url(#frownb)" transform="translate(14 8)"> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="2" stroke-linejoin="round" d="M0 0h2v4H0V0z"></path> </g> </g> </svg> <span class="c-form__label--visually-hidden">An image of a cartoon face with a frown.</span> <span><span class="c-form__label--visually-hidden"> The value of this radio input is: </span>Bad</span> </label> </div> <div class="c-forms__label c-forms__label--wrapper"> <input class="c-forms__input c-forms__input--radio" type="radio" id="radio-ok" name="customer-satisfaction-input-radios" value="3" required="" aria-required="true" autocomplete="off" data-customer-satisfaction-input="radio"> <label for="radio-ok" class="c-forms__label c-forms__label--pictographic-radio c-forms__label--boxed-icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="transparent" stroke="currentColor" aria-hidden="true" focusable="false" viewBox="0 0 24 24"> <defs> <clipPath id="neutrala"> <path d="M24 0v24H0V0h24Z"></path> </clipPath> <clipPath id="neutralb"> <path d="M1 0c.6 0 1 .4 1 1v2a1 1 0 1 1-2 0V1c0-.6.4-1 1-1Z"></path> </clipPath> </defs> <g clip-path="url(#neutrala)"> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="1.8" stroke-linejoin="round" d="M12 22a10 10 0 1 0 0-20 10 10 0 0 0 0 20Z"></path> <g clip-path="url(#neutralb)" transform="translate(8 8)"> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="2" stroke-linejoin="round" d="M0 0h2v4H0V0z"></path> </g> <g clip-path="url(#neutralb)" transform="translate(14 8)"> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="2" stroke-linejoin="round" d="M0 0h2v4H0V0z"></path> </g> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="1.8" stroke-linejoin="round" d="M9 16h6"></path> </g> </svg> <span class="c-form__label--visually-hidden">An image of a cartoon face with a neutral expression.</span> <span><span class="c-form__label--visually-hidden"> The value of this radio input is: </span>OK</span> </label> </div> <div class="c-forms__label c-forms__label--wrapper"> <input class="c-forms__input c-forms__input--radio" type="radio" id="radio-good" name="customer-satisfaction-input-radios" value="4" required="" aria-required="true" autocomplete="off" data-customer-satisfaction-input="radio"> <label for="radio-good" class="c-forms__label c-forms__label--pictographic-radio c-forms__label--boxed-icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="transparent" stroke="currentColor" aria-hidden="true" focusable="false" viewBox="0 0 24 24"> <defs> <clipPath id="smilea"> <path d="M24 0v24H0V0h24Z"></path> </clipPath> <clipPath id="smileb"> <path d="M1 0c.6 0 1 .4 1 1v2a1 1 0 1 1-2 0V1c0-.6.4-1 1-1Z"></path> </clipPath> </defs> <g clip-path="url(#smilea)"> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="1.8" stroke-linejoin="round" d="M12 22a10 10 0 1 0 0-20 10 10 0 0 0 0 20Z"></path> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="1.8" stroke-linejoin="round" d="M9 15c1 2.7 5 2.7 6 0"></path> <g clip-path="url(#smileb)" transform="translate(8 8)"> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="2" stroke-linejoin="round" d="M0 0h2v4H0V0z"></path> </g> <g clip-path="url(#smileb)" transform="translate(14 8)"> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="2" stroke-linejoin="round" d="M0 0h2v4H0V0z"></path> </g> </g> </svg> <span class="c-form__label--visually-hidden">An image of a cartoon face with a smile.</span> <span><span class="c-form__label--visually-hidden"> The value of this radio input is: </span>Good</span> </label> </div> <div class="c-forms__label c-forms__label--wrapper"> <input class="c-forms__input c-forms__input--radio" type="radio" id="radio-great" name="customer-satisfaction-input-radios" value="5" required="" aria-required="true" autocomplete="off" data-customer-satisfaction-input="radio"> <label for="radio-great" class="c-forms__label c-forms__label--pictographic-radio c-forms__label--boxed-icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="transparent" stroke="currentColor" aria-hidden="true" focusable="false" viewBox="0 0 24 24"> <defs> <clipPath id="grina"> <path d="M24 0v24H0V0h24Z"></path> </clipPath> </defs> <g clip-path="url(#grina)"> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="1.8" stroke-linejoin="round" d="M12 22a10 10 0 1 0 0-20 10 10 0 0 0 0 20Z"></path> <path stroke-linecap="round" stroke-miterlimit="10" stroke-width="1.8" stroke-linejoin="round" d="M17.5 10v-.5a1.7 1.7 0 0 0-3.5 0v.5M10 10v-.5a1.7 1.7 0 0 0-3.5 0v.5M8 14c.5 5 7.5 5 8 0H8Z"></path> </g> </svg> <span class="c-form__label--visually-hidden">An image of a cartoon face with an open mouth grin.</span> <span><span class="c-form__label--visually-hidden"> The value of this radio input is: </span>Great</span> </label> </div> </div> </fieldset> </div> </div> <button class="c-customer-satisfaction-input__button" type="submit">Send feedback</button> <div class="u-hide c-customer-satisfaction-input__submit-message" data-customer-satisfaction-input="submit-message"> <div> <svg xmlns="http://www.w3.org/2000/svg" id="i-circle-tick" viewBox="0 0 20 20" aria-hidden="true" focusable="false" fill="#00a79d"><path d="M10 0a10 10 0 1 0 0 20 10 10 0 0 0 0-20Z"></path><path d="M15 5.5a1 1 0 0 0-.8.4l-5.4 6-3.1-2.6a1 1 0 0 0-1.5.1 1 1 0 0 0 .2 1.5l3.9 3.4c.4.3 1 .3 1.4-.1l6-7c.4-.4.4-1 0-1.5a1 1 0 0 0-.8-.2Z" fill="#fff"></path></svg> <p>Thank you for your feedback.</p> </div> <a href="https://www.surveymonkey.co.uk/r/JTF2VYK" data-customer-satisfaction-input="survey-link" target="_blank" rel="noopener">Tell us why (opens in a new tab)</a> </div> </form> </div> </aside> </div> </main> <div class="c-page-layout__side u-text-sm"> <div class="c-separator c-submit-manuscript"> <a class="u-button u-button--full-width u-button--primary" href="https://submission.nature.com/new-submission/13040/3" data-track="click_submit_manuscript" data-track-action="manuscript submission" data-track-context="journal header on journal page" data-track-category="Journal" data-track-label="BioData Mining" data-track-external data-test="submit-manuscript-button">Submit manuscript<svg class="u-ml-8" width="15" height="16" aria-hidden="true" focusable="false"><use xlink:href="#icon-submit-open"></use></svg></a> </div> <div class="c-separator" data-fragment="693212"> <ul class="c-list-group c-list-group--bordered c-list-group c-list-group--md"> <li class="c-list-group__item"> <a class="teaser-placement" href="/about/editorial-board">Editorial Board</a> </li> <li class="c-list-group__item"> <a class="teaser-placement" href="https://www.biomedcentral.com/about/foreditors">Instructions for Editors</a> </li> <li class="c-list-group__item"> <a href="https://www.biomedcentral.com/add-article-alert?journalId=13040" data-track="click" data-track-category="Journal sidebar" data-track-action="Sign up for article alerts and news from this journal" data-track-label="BioData Mining">Sign up for article alerts and news from this journal</a> </li> </ul> </div> <div class="c-separator"> <h3>Follow</h3> <ul class="c-social-links"> <li class="c-social-links__item"> <a href="http://twitter.com/moorejh" data-track="click" data-track-category="Social Media" data-track-action="Click Follow Social Media" data-track-label="Twitter"> <span class="u-visually-hidden">Follow us on Twitter</span> <svg class="u-icon c-social-links__icon u-text-lg" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-twitter-bordered"></use> </svg> </a> </li> </ul> </div> <div class="c-separator" data-fragment="15276388"> <h3>Annual Journal Metrics</h3> <ul class="c-list-group c-list-group--bordered c-list-group c-list-group--md"> <li class="c-list-group__item"> <div class="cms-item cms-article cleared" data-fragment="15276390"> <div class="cms-article__body cleared"> <p><strong>Citation Impact 2023</strong><br> Journal Impact Factor: 4.0<br> 5-year Journal Impact Factor: 3.7<br> Source Normalized Impact per Paper (SNIP): 1.413<br> SCImago Journal Rank (SJR): 0.958<br><br><strong>Speed 2023</strong><br> Submission to first editorial decision (median days): 15<br> Submission to acceptance (median days): 171<br><br><strong>Usage 2023</strong><br> Downloads: 400,374<br> Altmetric mentions: 146<br> </p> </div> </div> </li> <li class="c-list-group__item"> <div class="cms-item" data-fragment="15324334"> <div> <div class="u-mb-16-at-xxs u-mb-16-at-xs"> <a href="https://www.biomedcentral.com/p/bmc-impact" class="u-button u-button--primary" data-test="teaser-button-link"> More about our metrics </a> </div> </div> </div> </li> </ul> </div> <aside class="adsbox c-ad c-ad--sticky c-ad--160x600 u-mt-16" data-component-mpu> <div class="c-ad__inner"> <p class="c-ad__label">Advertisement</p> <div id="div-gpt-ad-SKY1" data-ad-type="SKY1" data-test="SKY1-ad" data-pa11y-ignore data-gpt data-gpt-unitpath="/270604982/bmc/biodatamining" data-gpt-sizes="160x600" data-gpt-targeting="pos=SKY1;pmc=L17004,I23050,I18030,L15001,M14018;" > <noscript> <a href="//pubads.g.doubleclick.net/gampad/jump?iu=/270604982/bmc/biodatamining&sz=160x600&pos=SKY1&pmc=L17004,I23050,I18030,L15001,M14018&"> <img data-test="gpt-advert-fallback-img" src="//pubads.g.doubleclick.net/gampad/ad?iu=/270604982/bmc/biodatamining&sz=160x600&pos=SKY1&pmc=L17004,I23050,I18030,L15001,M14018&" alt="Advertisement" width="160" height="600"> </a> </noscript> </div> </div> </aside> </div> </div> </div> <div class="c-journal-footer"> <div class="c-journal-footer__inner"> <div class="c-journal-footer__summary"> <h4 class="c-journal-title c-journal-title--footer"> <img class="c-journal-title__logo" src="https://biodatamining.biomedcentral.com/images/13040/logo.svg"/> <span class="c-journal-title__text">BioData Mining</span> </h4> <p class="c-journal-footer__issn">ISSN: 1756-0381</p> </div> <div class="c-journal-footer__contact"> <h4 class="c-journal-footer__contact-title c-journal-footer__contact-title--adjust-for-logo">Contact us</h4> <ul class="c-journal-footer__contact-list"> <li class="c-journal-footer__contact-item">General enquiries: <a href="mailto:journalsubmissions@springernature.com">journalsubmissions@springernature.com</a></li> </ul> </div> </div> </div> <footer> <div class="c-publisher-footer u-color-inherit" data-test="publisher-footer"> <div class="u-container"> <div class="u-display-flex u-flex-wrap u-justify-content-space-between" data-test="publisher-footer-menu"> <div class="u-display-flex"> <ul class="c-list-group c-list-group--sm u-mr-24 u-mb-16"> <li class="c-list-group__item"> <a class="u-gray-link" href="https://blogs.biomedcentral.com/">Read more on our blogs</a> </li> <li class="c-list-group__item"> <a class="u-gray-link" href="//www.biomedcentral.com/login">Receive BMC newsletters</a> </li> <li class="c-list-group__item"> <a class="u-gray-link" href="//www.biomedcentral.com/account">Manage article alerts</a> </li> <li class="c-list-group__item"> <a class="u-gray-link" href="https://authorservices.springernature.com/go/sn/?utm_source=Website&utm_medium=BMC&utm_campaign=SNAS+Referrals+2022&utm_id=ref2022">Language editing for authors</a> </li> <li class="c-list-group__item"> <a class="u-gray-link" href="https://authorservices.springernature.com/go/sn/?utm_source=Website&utm_medium=BMC&utm_campaign=SNAS+Referrals+2022&utm_id=ref2022">Scientific editing for authors</a> </li> </ul> <ul class="c-list-group c-list-group--sm u-mr-24 u-mb-16"> <li class="c-list-group__item"> <a class="u-gray-link" href="//www.biomedcentral.com/about/policies">Policies</a> </li> <li class="c-list-group__item"> <a class="u-gray-link" href="//www.biomedcentral.com/accessibility">Accessibility</a> </li> <li class="c-list-group__item"> <a class="u-gray-link" href="//www.biomedcentral.com/about/press-centre">Press center</a> </li> </ul> <ul class="c-list-group c-list-group--sm u-mr-24 u-mb-16"> <li class="c-list-group__item"> <a class="u-gray-link" href="https://support.biomedcentral.com/support/home">Support and Contact</a> </li> <li class="c-list-group__item"> <a class="u-gray-link" href="https://biomedcentral.typeform.com/to/VLXboo">Leave feedback</a> </li> <li class="c-list-group__item"> <a class="u-gray-link" href="//www.biomedcentral.com/about/jobs">Careers</a> </li> </ul> </div> <div class="u-mb-24"> <h3 id="social-menu" class="u-text-sm u-reset-margin u-text-normal">Follow BMC</h3> <ul class="u-display-flex u-list-reset" data-test="footer-social-links"> <li class="u-mt-8 u-mr-8"> <a href="https://twitter.com/biomedcentral" data-track="click" data-track-category="Social" data-track-action="Clicked BMC Twitter" class="u-gray-link"> <span class="u-visually-hidden">BMC Twitter page</span> <svg class="u-icon u-text-lg" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-twitter-bordered"></use> </svg> </a> </li> <li class="u-mt-8 u-mr-8"> <a href="https://www.facebook.com/BioMedCentral" data-track="click" data-track-category="Social" data-track-action="Clicked BMC Facebook" class="u-gray-link"> <span class="u-visually-hidden">BMC Facebook page</span> <svg class="u-icon u-text-lg" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-facebook-bordered"></use> </svg> </a> </li> <li class="u-mt-8 u-mr-8"> <a href="http://www.weibo.com/biomedcentral" data-track="click" data-track-category="Social" data-track-action="Clicked BMC Weibo" class="u-gray-link"> <span class="u-visually-hidden">BMC Weibo page</span> <svg class="u-icon u-text-lg" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-weibo-bordered"></use> </svg> </a> </li> </ul> </div> </div> <p class="u-reset-margin"> By using this website, you agree to our <a class="u-gray-link" href="//www.biomedcentral.com/terms-and-conditions">Terms and Conditions</a>, <a class="u-gray-link" href="https://www.springernature.com/ccpa">Your US state privacy rights</a>, <a class="u-gray-link" href="//www.biomedcentral.com/privacy-statement">Privacy statement</a> and <a class="u-gray-link" href="//www.biomedcentral.com/cookies" data-test="cookie-link">Cookies</a> policy. <a class="u-gray-link" data-cc-action="preferences" href="javascript:void(0);">Your privacy choices/Manage cookies</a> we use in the preference centre. </p> </div> </div> <div class="c-corporate-footer"> <div class="u-container"> <img src=/static/images/logo-springernature-acb40b85fb.svg class="c-corporate-footer__logo" alt="Springer Nature" itemprop="logo" role="img"> <p class="c-corporate-footer__legal" data-test="copyright"> © 2024 BioMed Central Ltd unless otherwise stated. Part of <a class="c-corporate-footer__link" href="https://www.springernature.com" itemscope itemtype="http://schema.org/Organization" itemid="#parentOrganization">Springer Nature</a>. </p> </div> </div> </footer> </div> <script> window.dataLayer.push( { content: { attributes: { copyright: { openAccess: true } } } } ) </script> <div class="u-visually-hidden" aria-hidden="true"> <?xml version="1.0" encoding="UTF-8"?><!DOCTYPE svg PUBLIC "-//W3C//DTD SVG 1.1//EN" "http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><defs><path id="a" d="M0 .74h56.72v55.24H0z"/></defs><symbol id="icon-access" viewBox="0 0 18 18"><path d="m14 8c.5522847 0 1 .44771525 1 1v7h2.5c.2761424 0 .5.2238576.5.5v1.5h-18v-1.5c0-.2761424.22385763-.5.5-.5h2.5v-7c0-.55228475.44771525-1 1-1s1 .44771525 1 1v6.9996556h8v-6.9996556c0-.55228475.4477153-1 1-1zm-8 0 2 1v5l-2 1zm6 0v7l-2-1v-5zm-2.42653766-7.59857636 7.03554716 4.92488299c.4162533.29137735.5174853.86502537.226108 1.28127873-.1721584.24594054-.4534847.39241464-.7536934.39241464h-14.16284822c-.50810197 0-.92-.41189803-.92-.92 0-.30020869.1464741-.58153499.39241464-.75369337l7.03554714-4.92488299c.34432015-.2410241.80260453-.2410241 1.14692468 0zm-.57346234 2.03988748-3.65526982 2.55868888h7.31053962z" fill-rule="evenodd"/></symbol><symbol id="icon-account" viewBox="0 0 18 18"><path d="m10.2379028 16.9048051c1.3083556-.2032362 2.5118471-.7235183 3.5294683-1.4798399-.8731327-2.5141501-2.0638925-3.935978-3.7673711-4.3188248v-1.27684611c1.1651924-.41183641 2-1.52307546 2-2.82929429 0-1.65685425-1.3431458-3-3-3-1.65685425 0-3 1.34314575-3 3 0 1.30621883.83480763 2.41745788 2 2.82929429v1.27684611c-1.70347856.3828468-2.89423845 1.8046747-3.76737114 4.3188248 1.01762123.7563216 2.22111275 1.2766037 3.52946833 1.4798399.40563808.0629726.81921174.0951949 1.23790281.0951949s.83226473-.0322223 1.2379028-.0951949zm4.3421782-2.1721994c1.4927655-1.4532925 2.419919-3.484675 2.419919-5.7326057 0-4.418278-3.581722-8-8-8s-8 3.581722-8 8c0 2.2479307.92715352 4.2793132 2.41991895 5.7326057.75688473-2.0164459 1.83949951-3.6071894 3.48926591-4.3218837-1.14534283-.70360829-1.90918486-1.96796271-1.90918486-3.410722 0-2.209139 1.790861-4 4-4s4 1.790861 4 4c0 1.44275929-.763842 2.70711371-1.9091849 3.410722 1.6497664.7146943 2.7323812 2.3054378 3.4892659 4.3218837zm-5.580081 3.2673943c-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9 4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9z" fill-rule="evenodd"/></symbol><symbol id="icon-alert" viewBox="0 0 18 18"><path d="m4 10h2.5c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-3.08578644l-1.12132034 1.1213203c-.18753638.1875364-.29289322.4418903-.29289322.7071068v.1715729h14v-.1715729c0-.2652165-.1053568-.5195704-.2928932-.7071068l-1.7071068-1.7071067v-3.4142136c0-2.76142375-2.2385763-5-5-5-2.76142375 0-5 2.23857625-5 5zm3 4c0 1.1045695.8954305 2 2 2s2-.8954305 2-2zm-5 0c-.55228475 0-1-.4477153-1-1v-.1715729c0-.530433.21071368-1.0391408.58578644-1.4142135l1.41421356-1.4142136v-3c0-3.3137085 2.6862915-6 6-6s6 2.6862915 6 6v3l1.4142136 1.4142136c.3750727.3750727.5857864.8837805.5857864 1.4142135v.1715729c0 .5522847-.4477153 1-1 1h-4c0 1.6568542-1.3431458 3-3 3-1.65685425 0-3-1.3431458-3-3z" fill-rule="evenodd"/></symbol><symbol id="icon-arrow-broad" viewBox="0 0 16 16"><path d="m6.10307866 2.97190702v7.69043288l2.44965196-2.44676915c.38776071-.38730439 1.0088052-.39493524 1.38498697-.01919617.38609051.38563612.38643641 1.01053024-.00013864 1.39665039l-4.12239817 4.11754683c-.38616704.3857126-1.01187344.3861062-1.39846576-.0000311l-4.12258206-4.11773056c-.38618426-.38572979-.39254614-1.00476697-.01636437-1.38050605.38609047-.38563611 1.01018509-.38751562 1.4012233.00306241l2.44985644 2.4469734v-8.67638639c0-.54139983.43698413-.98042709.98493125-.98159081l7.89910522-.0043627c.5451687 0 .9871152.44142642.9871152.98595351s-.4419465.98595351-.9871152.98595351z" fill-rule="evenodd" transform="matrix(-1 0 0 -1 14 15)"/></symbol><symbol id="icon-arrow-down" viewBox="0 0 16 16"><path d="m3.28337502 11.5302405 4.03074001 4.176208c.37758093.3912076.98937525.3916069 1.367372-.0000316l4.03091977-4.1763942c.3775978-.3912252.3838182-1.0190815.0160006-1.4001736-.3775061-.39113013-.9877245-.39303641-1.3700683.003106l-2.39538585 2.4818345v-11.6147896l-.00649339-.11662112c-.055753-.49733869-.46370161-.88337888-.95867408-.88337888-.49497246 0-.90292107.38604019-.95867408.88337888l-.00649338.11662112v11.6147896l-2.39518594-2.4816273c-.37913917-.39282218-.98637524-.40056175-1.35419292-.0194697-.37750607.3911302-.37784433 1.0249269.00013556 1.4165479z" fill-rule="evenodd"/></symbol><symbol id="icon-arrow-left" viewBox="0 0 16 16"><path d="m4.46975946 3.28337502-4.17620792 4.03074001c-.39120768.37758093-.39160691.98937525.0000316 1.367372l4.1763942 4.03091977c.39122514.3775978 1.01908149.3838182 1.40017357.0160006.39113012-.3775061.3930364-.9877245-.00310603-1.3700683l-2.48183446-2.39538585h11.61478958l.1166211-.00649339c.4973387-.055753.8833789-.46370161.8833789-.95867408 0-.49497246-.3860402-.90292107-.8833789-.95867408l-.1166211-.00649338h-11.61478958l2.4816273-2.39518594c.39282216-.37913917.40056173-.98637524.01946965-1.35419292-.39113012-.37750607-1.02492687-.37784433-1.41654791.00013556z" fill-rule="evenodd"/></symbol><symbol id="icon-arrow-right" viewBox="0 0 16 16"><path d="m11.5302405 12.716625 4.176208-4.03074003c.3912076-.37758093.3916069-.98937525-.0000316-1.367372l-4.1763942-4.03091981c-.3912252-.37759778-1.0190815-.38381821-1.4001736-.01600053-.39113013.37750607-.39303641.98772445.003106 1.37006824l2.4818345 2.39538588h-11.6147896l-.11662112.00649339c-.49733869.055753-.88337888.46370161-.88337888.95867408 0 .49497246.38604019.90292107.88337888.95867408l.11662112.00649338h11.6147896l-2.4816273 2.39518592c-.39282218.3791392-.40056175.9863753-.0194697 1.3541929.3911302.3775061 1.0249269.3778444 1.4165479-.0001355z" fill-rule="evenodd"/></symbol><symbol id="icon-arrow-sub" viewBox="0 0 16 16"><path d="m7.89692134 4.97190702v7.69043288l-2.44965196-2.4467692c-.38776071-.38730434-1.0088052-.39493519-1.38498697-.0191961-.38609047.3856361-.38643643 1.0105302.00013864 1.3966504l4.12239817 4.1175468c.38616704.3857126 1.01187344.3861062 1.39846576-.0000311l4.12258202-4.1177306c.3861843-.3857298.3925462-1.0047669.0163644-1.380506-.3860905-.38563612-1.0101851-.38751563-1.4012233.0030624l-2.44985643 2.4469734v-8.67638639c0-.54139983-.43698413-.98042709-.98493125-.98159081l-7.89910525-.0043627c-.54516866 0-.98711517.44142642-.98711517.98595351s.44194651.98595351.98711517.98595351z" fill-rule="evenodd"/></symbol><symbol id="icon-arrow-up" viewBox="0 0 16 16"><path d="m12.716625 4.46975946-4.03074003-4.17620792c-.37758093-.39120768-.98937525-.39160691-1.367372.0000316l-4.03091981 4.1763942c-.37759778.39122514-.38381821 1.01908149-.01600053 1.40017357.37750607.39113012.98772445.3930364 1.37006824-.00310603l2.39538588-2.48183446v11.61478958l.00649339.1166211c.055753.4973387.46370161.8833789.95867408.8833789.49497246 0 .90292107-.3860402.95867408-.8833789l.00649338-.1166211v-11.61478958l2.39518592 2.4816273c.3791392.39282216.9863753.40056173 1.3541929.01946965.3775061-.39113012.3778444-1.02492687-.0001355-1.41654791z" fill-rule="evenodd"/></symbol><symbol id="icon-article" viewBox="0 0 18 18"><path d="m13 15v-12.9906311c0-.0073595-.0019884-.0093689.0014977-.0093689l-11.00158888.00087166v13.00506804c0 .5482678.44615281.9940603.99415146.9940603h10.27350412c-.1701701-.2941734-.2675644-.6357129-.2675644-1zm-12 .0059397v-13.00506804c0-.5562408.44704472-1.00087166.99850233-1.00087166h11.00299537c.5510129 0 .9985023.45190985.9985023 1.0093689v2.9906311h3v9.9914698c0 1.1065798-.8927712 2.0085302-1.9940603 2.0085302h-12.01187942c-1.09954652 0-1.99406028-.8927712-1.99406028-1.9940603zm13-9.0059397v9c0 .5522847.4477153 1 1 1s1-.4477153 1-1v-9zm-10-2h7v4h-7zm1 1v2h5v-2zm-1 4h7v1h-7zm0 2h7v1h-7zm0 2h7v1h-7z" fill-rule="evenodd"/></symbol><symbol id="icon-audio" viewBox="0 0 18 18"><path d="m13.0957477 13.5588459c-.195279.1937043-.5119137.193729-.7072234.0000551-.1953098-.193674-.1953346-.5077061-.0000556-.7014104 1.0251004-1.0168342 1.6108711-2.3905226 1.6108711-3.85745208 0-1.46604976-.5850634-2.83898246-1.6090736-3.85566829-.1951894-.19379323-.1950192-.50782531.0003802-.70141028.1953993-.19358497.512034-.19341614.7072234.00037709 1.2094886 1.20083761 1.901635 2.8250555 1.901635 4.55670148 0 1.73268608-.6929822 3.35779608-1.9037571 4.55880738zm2.1233994 2.1025159c-.195234.193749-.5118687.1938462-.7072235.0002171-.1953548-.1936292-.1954528-.5076613-.0002189-.7014104 1.5832215-1.5711805 2.4881302-3.6939808 2.4881302-5.96012998 0-2.26581266-.9046382-4.3883241-2.487443-5.95944795-.1952117-.19377107-.1950777-.50780316.0002993-.70141031s.5120117-.19347426.7072234.00029682c1.7683321 1.75528196 2.7800854 4.12911258 2.7800854 6.66056144 0 2.53182498-1.0120556 4.90597838-2.7808529 6.66132328zm-14.21898205-3.6854911c-.5523759 0-1.00016505-.4441085-1.00016505-.991944v-3.96777631c0-.54783558.44778915-.99194407 1.00016505-.99194407h2.0003301l5.41965617-3.8393633c.44948677-.31842296 1.07413994-.21516983 1.39520191.23062232.12116339.16823446.18629727.36981184.18629727.57655577v12.01603479c0 .5478356-.44778914.9919441-1.00016505.9919441-.20845738 0-.41170538-.0645985-.58133413-.184766l-5.41965617-3.8393633zm0-.991944h2.32084805l5.68047235 4.0241292v-12.01603479l-5.68047235 4.02412928h-2.32084805z" fill-rule="evenodd"/></symbol><symbol id="icon-block" viewBox="0 0 24 24"><path d="m0 0h24v24h-24z" fill-rule="evenodd"/></symbol><symbol id="icon-book" viewBox="0 0 18 18"><path d="m4 13v-11h1v11h11v-11h-13c-.55228475 0-1 .44771525-1 1v10.2675644c.29417337-.1701701.63571286-.2675644 1-.2675644zm12 1h-13c-.55228475 0-1 .4477153-1 1s.44771525 1 1 1h13zm0 3h-13c-1.1045695 0-2-.8954305-2-2v-12c0-1.1045695.8954305-2 2-2h13c.5522847 0 1 .44771525 1 1v14c0 .5522847-.4477153 1-1 1zm-8.5-13h6c.2761424 0 .5.22385763.5.5s-.2238576.5-.5.5h-6c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5zm1 2h4c.2761424 0 .5.22385763.5.5s-.2238576.5-.5.5h-4c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5z" fill-rule="evenodd"/></symbol><symbol id="icon-broad" viewBox="0 0 24 24"><path d="m9.18274226 7.81v7.7999954l2.48162734-2.4816273c.3928221-.3928221 1.0219731-.4005617 1.4030652-.0194696.3911301.3911301.3914806 1.0249268-.0001404 1.4165479l-4.17620796 4.1762079c-.39120769.3912077-1.02508144.3916069-1.41671995-.0000316l-4.1763942-4.1763942c-.39122514-.3912251-.39767006-1.0190815-.01657798-1.4001736.39113012-.3911301 1.02337106-.3930364 1.41951349.0031061l2.48183446 2.4818344v-8.7999954c0-.54911294.4426881-.99439484.99778758-.99557515l8.00221246-.00442485c.5522847 0 1 .44771525 1 1s-.4477153 1-1 1z" fill-rule="evenodd" transform="matrix(-1 0 0 -1 20.182742 24.805206)"/></symbol><symbol id="icon-calendar" viewBox="0 0 18 18"><path d="m12.5 0c.2761424 0 .5.21505737.5.49047852v.50952148h2c1.1072288 0 2 .89451376 2 2v12c0 1.1072288-.8945138 2-2 2h-12c-1.1072288 0-2-.8945138-2-2v-12c0-1.1072288.89451376-2 2-2h1v1h-1c-.55393837 0-1 .44579254-1 1v3h14v-3c0-.55393837-.4457925-1-1-1h-2v1.50952148c0 .27088381-.2319336.49047852-.5.49047852-.2761424 0-.5-.21505737-.5-.49047852v-3.01904296c0-.27088381.2319336-.49047852.5-.49047852zm3.5 7h-14v8c0 .5539384.44579254 1 1 1h12c.5539384 0 1-.4457925 1-1zm-11 6v1h-1v-1zm3 0v1h-1v-1zm3 0v1h-1v-1zm-6-2v1h-1v-1zm3 0v1h-1v-1zm6 0v1h-1v-1zm-3 0v1h-1v-1zm-3-2v1h-1v-1zm6 0v1h-1v-1zm-3 0v1h-1v-1zm-5.5-9c.27614237 0 .5.21505737.5.49047852v.50952148h5v1h-5v1.50952148c0 .27088381-.23193359.49047852-.5.49047852-.27614237 0-.5-.21505737-.5-.49047852v-3.01904296c0-.27088381.23193359-.49047852.5-.49047852z" fill-rule="evenodd"/></symbol><symbol id="icon-cart" viewBox="0 0 18 18"><path d="m5 14c1.1045695 0 2 .8954305 2 2s-.8954305 2-2 2-2-.8954305-2-2 .8954305-2 2-2zm10 0c1.1045695 0 2 .8954305 2 2s-.8954305 2-2 2-2-.8954305-2-2 .8954305-2 2-2zm-10 1c-.55228475 0-1 .4477153-1 1s.44771525 1 1 1 1-.4477153 1-1-.44771525-1-1-1zm10 0c-.5522847 0-1 .4477153-1 1s.4477153 1 1 1 1-.4477153 1-1-.4477153-1-1-1zm-12.82032249-15c.47691417 0 .88746157.33678127.98070211.80449199l.23823144 1.19501025 13.36277974.00045554c.5522847.00001882.9999659.44774934.9999659 1.00004222 0 .07084994-.0075361.14150708-.022474.2107727l-1.2908094 5.98534344c-.1007861.46742419-.5432548.80388386-1.0571651.80388386h-10.24805106c-.59173366 0-1.07142857.4477153-1.07142857 1 0 .5128358.41361449.9355072.94647737.9932723l.1249512.0067277h10.35933776c.2749512 0 .4979349.2228539.4979349.4978051 0 .2749417-.2227336.4978951-.4976753.4980063l-10.35959736.0041886c-1.18346732 0-2.14285714-.8954305-2.14285714-2 0-.6625717.34520317-1.24989198.87690425-1.61383592l-1.63768102-8.19004794c-.01312273-.06561364-.01950005-.131011-.0196107-.19547395l-1.71961253-.00064219c-.27614237 0-.5-.22385762-.5-.5 0-.27614237.22385763-.5.5-.5zm14.53193359 2.99950224h-13.11300004l1.20580469 6.02530174c.11024034-.0163252.22327998-.02480398.33844139-.02480398h10.27064786z"/></symbol><symbol id="icon-chevron-less" viewBox="0 0 10 10"><path d="m5.58578644 4-3.29289322-3.29289322c-.39052429-.39052429-.39052429-1.02368927 0-1.41421356s1.02368927-.39052429 1.41421356 0l4 4c.39052429.39052429.39052429 1.02368927 0 1.41421356l-4 4c-.39052429.39052429-1.02368927.39052429-1.41421356 0s-.39052429-1.02368927 0-1.41421356z" fill-rule="evenodd" transform="matrix(0 -1 -1 0 9 9)"/></symbol><symbol id="icon-chevron-more" viewBox="0 0 10 10"><path d="m5.58578644 6-3.29289322-3.29289322c-.39052429-.39052429-.39052429-1.02368927 0-1.41421356s1.02368927-.39052429 1.41421356 0l4 4c.39052429.39052429.39052429 1.02368927 0 1.41421356l-4 4.00000002c-.39052429.3905243-1.02368927.3905243-1.41421356 0s-.39052429-1.02368929 0-1.41421358z" fill-rule="evenodd" transform="matrix(0 1 -1 0 11 1)"/></symbol><symbol id="icon-chevron-right" viewBox="0 0 10 10"><path d="m5.96738168 4.70639573 2.39518594-2.41447274c.37913917-.38219212.98637524-.38972225 1.35419292-.01894278.37750606.38054586.37784436.99719163-.00013556 1.37821513l-4.03074001 4.06319683c-.37758093.38062133-.98937525.38100976-1.367372-.00003075l-4.03091981-4.06337806c-.37759778-.38063832-.38381821-.99150444-.01600053-1.3622839.37750607-.38054587.98772445-.38240057 1.37006824.00302197l2.39538588 2.4146743.96295325.98624457z" fill-rule="evenodd" transform="matrix(0 -1 1 0 0 10)"/></symbol><symbol id="icon-circle-fill" viewBox="0 0 16 16"><path d="m8 14c-3.3137085 0-6-2.6862915-6-6s2.6862915-6 6-6 6 2.6862915 6 6-2.6862915 6-6 6z" fill-rule="evenodd"/></symbol><symbol id="icon-circle" viewBox="0 0 16 16"><path d="m8 12c2.209139 0 4-1.790861 4-4s-1.790861-4-4-4-4 1.790861-4 4 1.790861 4 4 4zm0 2c-3.3137085 0-6-2.6862915-6-6s2.6862915-6 6-6 6 2.6862915 6 6-2.6862915 6-6 6z" fill-rule="evenodd"/></symbol><symbol id="icon-citation" viewBox="0 0 18 18"><path d="m8.63593473 5.99995183c2.20913897 0 3.99999997 1.79084375 3.99999997 3.99996146 0 1.40730761-.7267788 2.64486871-1.8254829 3.35783281 1.6240224.6764218 2.8754442 2.0093871 3.4610603 3.6412466l-1.0763845.000006c-.5310008-1.2078237-1.5108121-2.1940153-2.7691712-2.7181346l-.79002167-.329052v-1.023992l.63016577-.4089232c.8482885-.5504661 1.3698342-1.4895187 1.3698342-2.51898361 0-1.65683828-1.3431457-2.99996146-2.99999997-2.99996146-1.65685425 0-3 1.34312318-3 2.99996146 0 1.02946491.52154569 1.96851751 1.36983419 2.51898361l.63016581.4089232v1.023992l-.79002171.329052c-1.25835905.5241193-2.23817037 1.5103109-2.76917113 2.7181346l-1.07638453-.000006c.58561612-1.6318595 1.8370379-2.9648248 3.46106024-3.6412466-1.09870405-.7129641-1.82548287-1.9505252-1.82548287-3.35783281 0-2.20911771 1.790861-3.99996146 4-3.99996146zm7.36897597-4.99995183c1.1018574 0 1.9950893.89353404 1.9950893 2.00274083v5.994422c0 1.10608317-.8926228 2.00274087-1.9950893 2.00274087l-3.0049107-.0009037v-1l3.0049107.00091329c.5490631 0 .9950893-.44783123.9950893-1.00275046v-5.994422c0-.55646537-.4450595-1.00275046-.9950893-1.00275046h-14.00982141c-.54906309 0-.99508929.44783123-.99508929 1.00275046v5.9971821c0 .66666024.33333333.99999036 1 .99999036l2-.00091329v1l-2 .0009037c-1 0-2-.99999041-2-1.99998077v-5.9971821c0-1.10608322.8926228-2.00274083 1.99508929-2.00274083zm-8.5049107 2.9999711c.27614237 0 .5.22385547.5.5 0 .2761349-.22385763.5-.5.5h-4c-.27614237 0-.5-.2238651-.5-.5 0-.27614453.22385763-.5.5-.5zm3 0c.2761424 0 .5.22385547.5.5 0 .2761349-.2238576.5-.5.5h-1c-.27614237 0-.5-.2238651-.5-.5 0-.27614453.22385763-.5.5-.5zm4 0c.2761424 0 .5.22385547.5.5 0 .2761349-.2238576.5-.5.5h-2c-.2761424 0-.5-.2238651-.5-.5 0-.27614453.2238576-.5.5-.5z" fill-rule="evenodd"/></symbol><symbol id="icon-close" viewBox="0 0 16 16"><path d="m2.29679575 12.2772478c-.39658757.3965876-.39438847 1.0328109-.00062148 1.4265779.39651227.3965123 1.03246768.3934888 1.42657791-.0006214l4.27724782-4.27724787 4.2772478 4.27724787c.3965876.3965875 1.0328109.3943884 1.4265779.0006214.3965123-.3965122.3934888-1.0324677-.0006214-1.4265779l-4.27724787-4.2772478 4.27724787-4.27724782c.3965875-.39658757.3943884-1.03281091.0006214-1.42657791-.3965122-.39651226-1.0324677-.39348875-1.4265779.00062148l-4.2772478 4.27724782-4.27724782-4.27724782c-.39658757-.39658757-1.03281091-.39438847-1.42657791-.00062148-.39651226.39651227-.39348875 1.03246768.00062148 1.42657791l4.27724782 4.27724782z" fill-rule="evenodd"/></symbol><symbol id="icon-collections" viewBox="0 0 18 18"><path d="m15 4c1.1045695 0 2 .8954305 2 2v9c0 1.1045695-.8954305 2-2 2h-8c-1.1045695 0-2-.8954305-2-2h1c0 .5128358.38604019.9355072.88337887.9932723l.11662113.0067277h8c.5128358 0 .9355072-.3860402.9932723-.8833789l.0067277-.1166211v-9c0-.51283584-.3860402-.93550716-.8833789-.99327227l-.1166211-.00672773h-1v-1zm-4-3c1.1045695 0 2 .8954305 2 2v9c0 1.1045695-.8954305 2-2 2h-8c-1.1045695 0-2-.8954305-2-2v-9c0-1.1045695.8954305-2 2-2zm0 1h-8c-.51283584 0-.93550716.38604019-.99327227.88337887l-.00672773.11662113v9c0 .5128358.38604019.9355072.88337887.9932723l.11662113.0067277h8c.5128358 0 .9355072-.3860402.9932723-.8833789l.0067277-.1166211v-9c0-.51283584-.3860402-.93550716-.8833789-.99327227zm-1.5 7c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-5c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5zm0-2c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-5c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5zm0-2c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-5c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5z" fill-rule="evenodd"/></symbol><symbol id="icon-compare" viewBox="0 0 18 18"><path d="m12 3c3.3137085 0 6 2.6862915 6 6s-2.6862915 6-6 6c-1.0928452 0-2.11744941-.2921742-2.99996061-.8026704-.88181407.5102749-1.90678042.8026704-3.00003939.8026704-3.3137085 0-6-2.6862915-6-6s2.6862915-6 6-6c1.09325897 0 2.11822532.29239547 3.00096303.80325037.88158756-.51107621 1.90619177-.80325037 2.99903697-.80325037zm-6 1c-2.76142375 0-5 2.23857625-5 5 0 2.7614237 2.23857625 5 5 5 .74397391 0 1.44999672-.162488 2.08451611-.4539116-1.27652344-1.1000812-2.08451611-2.7287264-2.08451611-4.5460884s.80799267-3.44600721 2.08434391-4.5463015c-.63434719-.29121054-1.34037-.4536985-2.08434391-.4536985zm6 0c-.7439739 0-1.4499967.16248796-2.08451611.45391156 1.27652341 1.10008123 2.08451611 2.72872644 2.08451611 4.54608844s-.8079927 3.4460072-2.08434391 4.5463015c.63434721.2912105 1.34037001.4536985 2.08434391.4536985 2.7614237 0 5-2.2385763 5-5 0-2.76142375-2.2385763-5-5-5zm-1.4162763 7.0005324h-3.16744736c.15614659.3572676.35283837.6927622.58425872 1.0006671h1.99892988c.23142036-.3079049.42811216-.6433995.58425876-1.0006671zm.4162763-2.0005324h-4c0 .34288501.0345146.67770871.10025909 1.0011864h3.79948181c.0657445-.32347769.1002591-.65830139.1002591-1.0011864zm-.4158423-1.99953894h-3.16831543c-.13859957.31730812-.24521946.651783-.31578599.99935097h3.79988742c-.0705665-.34756797-.1771864-.68204285-.315786-.99935097zm-1.58295822-1.999926-.08316107.06199199c-.34550042.27081213-.65446126.58611297-.91825862.93727862h2.00044041c-.28418626-.37830727-.6207872-.71499149-.99902072-.99927061z" fill-rule="evenodd"/></symbol><symbol id="icon-download-file" viewBox="0 0 18 18"><path d="m10.0046024 0c.5497429 0 1.3179837.32258606 1.707238.71184039l4.5763192 4.57631922c.3931386.39313859.7118404 1.16760135.7118404 1.71431368v8.98899651c0 1.1092806-.8945138 2.0085302-1.9940603 2.0085302h-12.01187942c-1.10128908 0-1.99406028-.8926228-1.99406028-1.9950893v-14.00982141c0-1.10185739.88743329-1.99508929 1.99961498-1.99508929zm0 1h-7.00498742c-.55709576 0-.99961498.44271433-.99961498.99508929v14.00982141c0 .5500396.44491393.9950893.99406028.9950893h12.01187942c.5463747 0 .9940603-.4506622.9940603-1.0085302v-8.98899651c0-.28393444-.2150684-.80332809-.4189472-1.0072069l-4.5763192-4.57631922c-.2038461-.20384606-.718603-.41894717-1.0001312-.41894717zm-1.5046024 4c.27614237 0 .5.21637201.5.49209595v6.14827645l1.7462789-1.77990922c.1933927-.1971171.5125222-.19455839.7001689-.0069117.1932998.19329992.1910058.50899492-.0027774.70277812l-2.59089271 2.5908927c-.19483374.1948337-.51177825.1937771-.70556873-.0000133l-2.59099079-2.5909908c-.19484111-.1948411-.19043735-.5151448-.00279066-.70279146.19329987-.19329987.50465175-.19237083.70018565.00692852l1.74638684 1.78001764v-6.14827695c0-.27177709.23193359-.49209595.5-.49209595z" fill-rule="evenodd"/></symbol><symbol id="icon-download" viewBox="0 0 16 16"><path d="m12.9975267 12.999368c.5467123 0 1.0024733.4478567 1.0024733 1.000316 0 .5563109-.4488226 1.000316-1.0024733 1.000316h-9.99505341c-.54671233 0-1.00247329-.4478567-1.00247329-1.000316 0-.5563109.44882258-1.000316 1.00247329-1.000316zm-4.9975267-11.999368c.55228475 0 1 .44497754 1 .99589209v6.80214418l2.4816273-2.48241149c.3928222-.39294628 1.0219732-.4006883 1.4030652-.01947579.3911302.39125371.3914806 1.02525073-.0001404 1.41699553l-4.17620792 4.17752758c-.39120769.3913313-1.02508144.3917306-1.41671995-.0000316l-4.17639421-4.17771394c-.39122513-.39134876-.39767006-1.01940351-.01657797-1.40061601.39113012-.39125372 1.02337105-.3931606 1.41951349.00310701l2.48183446 2.48261871v-6.80214418c0-.55001601.44386482-.99589209 1-.99589209z" fill-rule="evenodd"/></symbol><symbol id="icon-editors" viewBox="0 0 18 18"><path d="m8.72592184 2.54588137c-.48811714-.34391207-1.08343326-.54588137-1.72592184-.54588137-1.65685425 0-3 1.34314575-3 3 0 1.02947485.5215457 1.96853646 1.3698342 2.51900785l.6301658.40892721v1.02400182l-.79002171.32905522c-1.93395773.8055207-3.20997829 2.7024791-3.20997829 4.8180274v.9009805h-1v-.9009805c0-2.5479714 1.54557359-4.79153984 3.82548288-5.7411543-1.09870406-.71297106-1.82548288-1.95054399-1.82548288-3.3578652 0-2.209139 1.790861-4 4-4 1.09079823 0 2.07961816.43662103 2.80122451 1.1446278-.37707584.09278571-.7373238.22835063-1.07530267.40125357zm-2.72592184 14.45411863h-1v-.9009805c0-2.5479714 1.54557359-4.7915398 3.82548288-5.7411543-1.09870406-.71297106-1.82548288-1.95054399-1.82548288-3.3578652 0-2.209139 1.790861-4 4-4s4 1.790861 4 4c0 1.40732121-.7267788 2.64489414-1.8254829 3.3578652 2.2799093.9496145 3.8254829 3.1931829 3.8254829 5.7411543v.9009805h-1v-.9009805c0-2.1155483-1.2760206-4.0125067-3.2099783-4.8180274l-.7900217-.3290552v-1.02400184l.6301658-.40892721c.8482885-.55047139 1.3698342-1.489533 1.3698342-2.51900785 0-1.65685425-1.3431458-3-3-3-1.65685425 0-3 1.34314575-3 3 0 1.02947485.5215457 1.96853646 1.3698342 2.51900785l.6301658.40892721v1.02400184l-.79002171.3290552c-1.93395773.8055207-3.20997829 2.7024791-3.20997829 4.8180274z" fill-rule="evenodd"/></symbol><symbol id="icon-email" viewBox="0 0 18 18"><path d="m16.0049107 2c1.1018574 0 1.9950893.89706013 1.9950893 2.00585866v9.98828264c0 1.1078052-.8926228 2.0058587-1.9950893 2.0058587h-14.00982141c-1.10185739 0-1.99508929-.8970601-1.99508929-2.0058587v-9.98828264c0-1.10780515.8926228-2.00585866 1.99508929-2.00585866zm0 1h-14.00982141c-.54871518 0-.99508929.44887827-.99508929 1.00585866v9.98828264c0 .5572961.44630695 1.0058587.99508929 1.0058587h14.00982141c.5487152 0 .9950893-.4488783.9950893-1.0058587v-9.98828264c0-.55729607-.446307-1.00585866-.9950893-1.00585866zm-.0049107 2.55749512v1.44250488l-7 4-7-4v-1.44250488l7 4z" fill-rule="evenodd"/></symbol><symbol id="icon-error" viewBox="0 0 18 18"><path d="m9 0c4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9zm2.8630343 4.71100931-2.8630343 2.86303426-2.86303426-2.86303426c-.39658757-.39658757-1.03281091-.39438847-1.4265779-.00062147-.39651227.39651226-.39348876 1.03246767.00062147 1.4265779l2.86303426 2.86303426-2.86303426 2.8630343c-.39658757.3965875-.39438847 1.0328109-.00062147 1.4265779.39651226.3965122 1.03246767.3934887 1.4265779-.0006215l2.86303426-2.8630343 2.8630343 2.8630343c.3965875.3965876 1.0328109.3943885 1.4265779.0006215.3965122-.3965123.3934887-1.0324677-.0006215-1.4265779l-2.8630343-2.8630343 2.8630343-2.86303426c.3965876-.39658757.3943885-1.03281091.0006215-1.4265779-.3965123-.39651227-1.0324677-.39348876-1.4265779.00062147z" fill-rule="evenodd"/></symbol><symbol id="icon-ethics" viewBox="0 0 18 18"><path d="m6.76384967 1.41421356.83301651-.8330165c.77492941-.77492941 2.03133823-.77492941 2.80626762 0l.8330165.8330165c.3750728.37507276.8837806.58578644 1.4142136.58578644h1.3496361c1.1045695 0 2 .8954305 2 2v1.34963611c0 .53043298.2107137 1.03914081.5857864 1.41421356l.8330165.83301651c.7749295.77492941.7749295 2.03133823 0 2.80626762l-.8330165.8330165c-.3750727.3750728-.5857864.8837806-.5857864 1.4142136v1.3496361c0 1.1045695-.8954305 2-2 2h-1.3496361c-.530433 0-1.0391408.2107137-1.4142136.5857864l-.8330165.8330165c-.77492939.7749295-2.03133821.7749295-2.80626762 0l-.83301651-.8330165c-.37507275-.3750727-.88378058-.5857864-1.41421356-.5857864h-1.34963611c-1.1045695 0-2-.8954305-2-2v-1.3496361c0-.530433-.21071368-1.0391408-.58578644-1.4142136l-.8330165-.8330165c-.77492941-.77492939-.77492941-2.03133821 0-2.80626762l.8330165-.83301651c.37507276-.37507275.58578644-.88378058.58578644-1.41421356v-1.34963611c0-1.1045695.8954305-2 2-2h1.34963611c.53043298 0 1.03914081-.21071368 1.41421356-.58578644zm-1.41421356 1.58578644h-1.34963611c-.55228475 0-1 .44771525-1 1v1.34963611c0 .79564947-.31607052 1.55871121-.87867966 2.12132034l-.8330165.83301651c-.38440512.38440512-.38440512 1.00764896 0 1.39205408l.8330165.83301646c.56260914.5626092.87867966 1.3256709.87867966 2.1213204v1.3496361c0 .5522847.44771525 1 1 1h1.34963611c.79564947 0 1.55871121.3160705 2.12132034.8786797l.83301651.8330165c.38440512.3844051 1.00764896.3844051 1.39205408 0l.83301646-.8330165c.5626092-.5626092 1.3256709-.8786797 2.1213204-.8786797h1.3496361c.5522847 0 1-.4477153 1-1v-1.3496361c0-.7956495.3160705-1.5587112.8786797-2.1213204l.8330165-.83301646c.3844051-.38440512.3844051-1.00764896 0-1.39205408l-.8330165-.83301651c-.5626092-.56260913-.8786797-1.32567087-.8786797-2.12132034v-1.34963611c0-.55228475-.4477153-1-1-1h-1.3496361c-.7956495 0-1.5587112-.31607052-2.1213204-.87867966l-.83301646-.8330165c-.38440512-.38440512-1.00764896-.38440512-1.39205408 0l-.83301651.8330165c-.56260913.56260914-1.32567087.87867966-2.12132034.87867966zm3.58698944 11.4960218c-.02081224.002155-.04199226.0030286-.06345763.002542-.98766446-.0223875-1.93408568-.3063547-2.75885125-.8155622-.23496767-.1450683-.30784554-.4531483-.16277726-.688116.14506827-.2349677.45314827-.3078455.68811595-.1627773.67447084.4164161 1.44758575.6483839 2.25617384.6667123.01759529.0003988.03495764.0017019.05204365.0038639.01713363-.0017748.03452416-.0026845.05212715-.0026845 2.4852814 0 4.5-2.0147186 4.5-4.5 0-1.04888973-.3593547-2.04134635-1.0074477-2.83787157-.1742817-.21419731-.1419238-.5291218.0722736-.70340353.2141973-.17428173.5291218-.14192375.7034035.07227357.7919032.97327203 1.2317706 2.18808682 1.2317706 3.46900153 0 3.0375661-2.4624339 5.5-5.5 5.5-.02146768 0-.04261937-.0013529-.06337445-.0039782zm1.57975095-10.78419583c.2654788.07599731.419084.35281842.3430867.61829728-.0759973.26547885-.3528185.419084-.6182973.3430867-.37560116-.10752146-.76586237-.16587951-1.15568824-.17249193-2.5587807-.00064534-4.58547766 2.00216524-4.58547766 4.49928198 0 .62691557.12797645 1.23496.37274865 1.7964426.11035133.2531347-.0053975.5477984-.25853224.6581497-.25313473.1103514-.54779841-.0053975-.65814974-.2585322-.29947131-.6869568-.45606667-1.43097603-.45606667-2.1960601 0-3.05211432 2.47714695-5.50006595 5.59399617-5.49921198.48576182.00815502.96289603.0795037 1.42238033.21103795zm-1.9766658 6.41091303 2.69835-2.94655317c.1788432-.21040373.4943901-.23598862.7047939-.05714545.2104037.17884318.2359886.49439014.0571454.70479387l-3.01637681 3.34277395c-.18039088.1999106-.48669547.2210637-.69285412.0478478l-1.93095347-1.62240047c-.21213845-.17678204-.24080048-.49206439-.06401844-.70420284.17678204-.21213844.49206439-.24080048.70420284-.06401844z" fill-rule="evenodd"/></symbol><symbol id="icon-expand"><path d="M7.498 11.918a.997.997 0 0 0-.003-1.411.995.995 0 0 0-1.412-.003l-4.102 4.102v-3.51A1 1 0 0 0 .98 10.09.992.992 0 0 0 0 11.092V17c0 .554.448 1.002 1.002 1.002h5.907c.554 0 1.002-.45 1.002-1.003 0-.539-.45-.978-1.006-.978h-3.51zm3.005-5.835a.997.997 0 0 0 .003 1.412.995.995 0 0 0 1.411.003l4.103-4.103v3.51a1 1 0 0 0 1.001 1.006A.992.992 0 0 0 18 6.91V1.002A1 1 0 0 0 17 0h-5.907a1.003 1.003 0 0 0-1.002 1.003c0 .539.45.978 1.006.978h3.51z" fill-rule="evenodd"/></symbol><symbol id="icon-explore" viewBox="0 0 18 18"><path d="m9 17c4.418278 0 8-3.581722 8-8s-3.581722-8-8-8-8 3.581722-8 8 3.581722 8 8 8zm0 1c-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9 4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9zm0-2.5c-.27614237 0-.5-.2238576-.5-.5s.22385763-.5.5-.5c2.969509 0 5.400504-2.3575119 5.497023-5.31714844.0090007-.27599565.2400359-.49243782.5160315-.48343711.2759957.0090007.4924378.2400359.4834371.51603155-.114093 3.4985237-2.9869632 6.284554-6.4964916 6.284554zm-.29090657-12.99359748c.27587424-.01216621.50937715.20161139.52154336.47748563.01216621.27587423-.20161139.50937715-.47748563.52154336-2.93195733.12930094-5.25315116 2.54886451-5.25315116 5.49456849 0 .27614237-.22385763.5-.5.5s-.5-.22385763-.5-.5c0-3.48142406 2.74307146-6.34074398 6.20909343-6.49359748zm1.13784138 8.04763908-1.2004882-1.20048821c-.19526215-.19526215-.19526215-.51184463 0-.70710678s.51184463-.19526215.70710678 0l1.20048821 1.2004882 1.6006509-4.00162734-4.50670359 1.80268144-1.80268144 4.50670359zm4.10281269-6.50378907-2.6692597 6.67314927c-.1016411.2541026-.3029834.4554449-.557086.557086l-6.67314927 2.6692597 2.66925969-6.67314926c.10164107-.25410266.30298336-.45544495.55708602-.55708602z" fill-rule="evenodd"/></symbol><symbol id="icon-filter" viewBox="0 0 16 16"><path d="m14.9738641 0c.5667192 0 1.0261359.4477136 1.0261359 1 0 .24221858-.0902161.47620768-.2538899.65849851l-5.6938314 6.34147206v5.49997973c0 .3147562-.1520673.6111434-.4104543.7999971l-2.05227171 1.4999945c-.45337535.3313696-1.09655869.2418269-1.4365902-.1999993-.13321514-.1730955-.20522717-.3836284-.20522717-.5999978v-6.99997423l-5.69383133-6.34147206c-.3731872-.41563511-.32996891-1.0473954.09653074-1.41107611.18705584-.15950448.42716133-.2474224.67571519-.2474224zm-5.9218641 8.5h-2.105v6.491l.01238459.0070843.02053271.0015705.01955278-.0070558 2.0532976-1.4990996zm-8.02585008-7.5-.01564945.00240169 5.83249953 6.49759831h2.313l5.836-6.499z"/></symbol><symbol id="icon-home" viewBox="0 0 18 18"><path d="m9 5-6 6v5h4v-4h4v4h4v-5zm7 6.5857864v4.4142136c0 .5522847-.4477153 1-1 1h-5v-4h-2v4h-5c-.55228475 0-1-.4477153-1-1v-4.4142136c-.25592232 0-.51184464-.097631-.70710678-.2928932l-.58578644-.5857864c-.39052429-.3905243-.39052429-1.02368929 0-1.41421358l8.29289322-8.29289322 8.2928932 8.29289322c.3905243.39052429.3905243 1.02368928 0 1.41421358l-.5857864.5857864c-.1952622.1952622-.4511845.2928932-.7071068.2928932zm-7-9.17157284-7.58578644 7.58578644.58578644.5857864 7-6.99999996 7 6.99999996.5857864-.5857864z" fill-rule="evenodd"/></symbol><symbol id="icon-image" viewBox="0 0 18 18"><path d="m10.0046024 0c.5497429 0 1.3179837.32258606 1.707238.71184039l4.5763192 4.57631922c.3931386.39313859.7118404 1.16760135.7118404 1.71431368v8.98899651c0 1.1092806-.8945138 2.0085302-1.9940603 2.0085302h-12.01187942c-1.10128908 0-1.99406028-.8926228-1.99406028-1.9950893v-14.00982141c0-1.10185739.88743329-1.99508929 1.99961498-1.99508929zm-3.49645283 10.1752453-3.89407257 6.7495552c.11705545.048464.24538859.0751995.37998328.0751995h10.60290092l-2.4329715-4.2154691-1.57494129 2.7288098zm8.49779013 6.8247547c.5463747 0 .9940603-.4506622.9940603-1.0085302v-8.98899651c0-.28393444-.2150684-.80332809-.4189472-1.0072069l-4.5763192-4.57631922c-.2038461-.20384606-.718603-.41894717-1.0001312-.41894717h-7.00498742c-.55709576 0-.99961498.44271433-.99961498.99508929v13.98991071l4.50814957-7.81026689 3.08089884 5.33809539 1.57494129-2.7288097 3.5875735 6.2159812zm-3.0059397-11c1.1045695 0 2 .8954305 2 2s-.8954305 2-2 2-2-.8954305-2-2 .8954305-2 2-2zm0 1c-.5522847 0-1 .44771525-1 1s.4477153 1 1 1 1-.44771525 1-1-.4477153-1-1-1z" fill-rule="evenodd"/></symbol><symbol id="icon-info" viewBox="0 0 18 18"><path d="m9 0c4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9zm0 7h-1.5l-.11662113.00672773c-.49733868.05776511-.88337887.48043643-.88337887.99327227 0 .47338693.32893365.86994729.77070917.97358929l.1126697.01968298.11662113.00672773h.5v3h-.5l-.11662113.0067277c-.42082504.0488782-.76196299.3590206-.85696816.7639815l-.01968298.1126697-.00672773.1166211.00672773.1166211c.04887817.4208251.35902055.761963.76398144.8569682l.1126697.019683.11662113.0067277h3l.1166211-.0067277c.4973387-.0577651.8833789-.4804365.8833789-.9932723 0-.4733869-.3289337-.8699473-.7707092-.9735893l-.1126697-.019683-.1166211-.0067277h-.5v-4l-.00672773-.11662113c-.04887817-.42082504-.35902055-.76196299-.76398144-.85696816l-.1126697-.01968298zm0-3.25c-.69035594 0-1.25.55964406-1.25 1.25s.55964406 1.25 1.25 1.25 1.25-.55964406 1.25-1.25-.55964406-1.25-1.25-1.25z" fill-rule="evenodd"/></symbol><symbol id="icon-institution" viewBox="0 0 18 18"><path d="m7 16.9998189v-2.0003623h4v2.0003623h2v-3.0005434h-8v3.0005434zm-3-10.00181122h-1.52632364c-.27614237 0-.5-.22389817-.5-.50009056 0-.13995446.05863589-.27350497.16166338-.36820841l1.23156713-1.13206327h-2.36690687v12.00217346h3v-2.0003623h-3v-1.0001811h3v-1.0001811h1v-4.00072448h-1zm10 0v2.00036224h-1v4.00072448h1v1.0001811h3v1.0001811h-3v2.0003623h3v-12.00217346h-2.3695309l1.2315671 1.13206327c.2033191.186892.2166633.50325042.0298051.70660631-.0946863.10304615-.2282126.16169266-.3681417.16169266zm3-3.00054336c.5522847 0 1 .44779634 1 1.00018112v13.00235456h-18v-13.00235456c0-.55238478.44771525-1.00018112 1-1.00018112h3.45499992l4.20535144-3.86558216c.19129876-.17584288.48537447-.17584288.67667324 0l4.2053514 3.86558216zm-4 3.00054336h-8v1.00018112h8zm-2 6.00108672h1v-4.00072448h-1zm-1 0v-4.00072448h-2v4.00072448zm-3 0v-4.00072448h-1v4.00072448zm8-4.00072448c.5522847 0 1 .44779634 1 1.00018112v2.00036226h-2v-2.00036226c0-.55238478.4477153-1.00018112 1-1.00018112zm-12 0c.55228475 0 1 .44779634 1 1.00018112v2.00036226h-2v-2.00036226c0-.55238478.44771525-1.00018112 1-1.00018112zm5.99868798-7.81907007-5.24205601 4.81852671h10.48411203zm.00131202 3.81834559c-.55228475 0-1-.44779634-1-1.00018112s.44771525-1.00018112 1-1.00018112 1 .44779634 1 1.00018112-.44771525 1.00018112-1 1.00018112zm-1 11.00199236v1.0001811h2v-1.0001811z" fill-rule="evenodd"/></symbol><symbol id="icon-location" viewBox="0 0 18 18"><path d="m9.39521328 16.2688008c.79596342-.7770119 1.59208152-1.6299956 2.33285652-2.5295081 1.4020032-1.7024324 2.4323601-3.3624519 2.9354918-4.871847.2228715-.66861448.3364384-1.29323246.3364384-1.8674457 0-3.3137085-2.6862915-6-6-6-3.36356866 0-6 2.60156856-6 6 0 .57421324.11356691 1.19883122.3364384 1.8674457.50313169 1.5093951 1.53348863 3.1694146 2.93549184 4.871847.74077492.8995125 1.53689309 1.7524962 2.33285648 2.5295081.13694479.1336842.26895677.2602648.39521328.3793207.12625651-.1190559.25826849-.2456365.39521328-.3793207zm-.39521328 1.7311992s-7-6-7-11c0-4 3.13400675-7 7-7 3.8659932 0 7 3.13400675 7 7 0 5-7 11-7 11zm0-8c-1.65685425 0-3-1.34314575-3-3s1.34314575-3 3-3c1.6568542 0 3 1.34314575 3 3s-1.3431458 3-3 3zm0-1c1.1045695 0 2-.8954305 2-2s-.8954305-2-2-2-2 .8954305-2 2 .8954305 2 2 2z" fill-rule="evenodd"/></symbol><symbol id="icon-minus" viewBox="0 0 16 16"><path d="m2.00087166 7h11.99825664c.5527662 0 1.0008717.44386482 1.0008717 1 0 .55228475-.4446309 1-1.0008717 1h-11.99825664c-.55276616 0-1.00087166-.44386482-1.00087166-1 0-.55228475.44463086-1 1.00087166-1z" fill-rule="evenodd"/></symbol><symbol id="icon-newsletter" viewBox="0 0 18 18"><path d="m9 11.8482489 2-1.1428571v-1.7053918h-4v1.7053918zm-3-1.7142857v-2.1339632h6v2.1339632l3-1.71428574v-6.41967746h-12v6.41967746zm10-5.3839632 1.5299989.95624934c.2923814.18273835.4700011.50320827.4700011.8479983v8.44575236c0 1.1045695-.8954305 2-2 2h-14c-1.1045695 0-2-.8954305-2-2v-8.44575236c0-.34479003.1776197-.66525995.47000106-.8479983l1.52999894-.95624934v-2.75c0-.55228475.44771525-1 1-1h12c.5522847 0 1 .44771525 1 1zm0 1.17924764v3.07075236l-7 4-7-4v-3.07075236l-1 .625v8.44575236c0 .5522847.44771525 1 1 1h14c.5522847 0 1-.4477153 1-1v-8.44575236zm-10-1.92924764h6v1h-6zm-1 2h8v1h-8z" fill-rule="evenodd"/></symbol><symbol id="icon-orcid" viewBox="0 0 18 18"><path d="m9 1c4.418278 0 8 3.581722 8 8s-3.581722 8-8 8-8-3.581722-8-8 3.581722-8 8-8zm-2.90107518 5.2732337h-1.41865256v7.1712107h1.41865256zm4.55867178.02508949h-2.99247027v7.14612121h2.91062487c.7673039 0 1.4476365-.1483432 2.0410182-.445034s1.0511995-.7152915 1.3734671-1.2558144c.3222677-.540523.4833991-1.1603247.4833991-1.85942385 0-.68545815-.1602789-1.30270225-.4808414-1.85175082-.3205625-.54904856-.7707074-.97532211-1.3504481-1.27883343-.5797408-.30351132-1.2413173-.45526471-1.9847495-.45526471zm-.1892674 1.07933542c.7877654 0 1.4143875.22336734 1.8798852.67010873.4654977.44674138.698243 1.05546001.698243 1.82617415 0 .74343221-.2310402 1.34447791-.6931277 1.80315511-.4620874.4586773-1.0750688.6880124-1.8389625.6880124h-1.46810075v-4.98745039zm-5.08652545-3.71099194c-.21825533 0-.410525.08444276-.57681478.25333081-.16628977.16888806-.24943341.36245684-.24943341.58071218 0 .22345188.08314364.41961891.24943341.58850696.16628978.16888806.35855945.25333082.57681478.25333082.233845 0 .43390938-.08314364.60019916-.24943342.16628978-.16628977.24943342-.36375592.24943342-.59240436 0-.233845-.08314364-.43131115-.24943342-.59240437s-.36635416-.24163862-.60019916-.24163862z" fill-rule="evenodd"/></symbol><symbol id="icon-plus" viewBox="0 0 16 16"><path d="m2.00087166 7h4.99912834v-4.99912834c0-.55276616.44386482-1.00087166 1-1.00087166.55228475 0 1 .44463086 1 1.00087166v4.99912834h4.9991283c.5527662 0 1.0008717.44386482 1.0008717 1 0 .55228475-.4446309 1-1.0008717 1h-4.9991283v4.9991283c0 .5527662-.44386482 1.0008717-1 1.0008717-.55228475 0-1-.4446309-1-1.0008717v-4.9991283h-4.99912834c-.55276616 0-1.00087166-.44386482-1.00087166-1 0-.55228475.44463086-1 1.00087166-1z" fill-rule="evenodd"/></symbol><symbol id="icon-print" viewBox="0 0 18 18"><path d="m16.0049107 5h-14.00982141c-.54941618 0-.99508929.4467783-.99508929.99961498v6.00077002c0 .5570958.44271433.999615.99508929.999615h1.00491071v-3h12v3h1.0049107c.5494162 0 .9950893-.4467783.9950893-.999615v-6.00077002c0-.55709576-.4427143-.99961498-.9950893-.99961498zm-2.0049107-1v-2.00208688c0-.54777062-.4519464-.99791312-1.0085302-.99791312h-7.9829396c-.55661731 0-1.0085302.44910695-1.0085302.99791312v2.00208688zm1 10v2.0018986c0 1.103521-.9019504 1.9981014-2.0085302 1.9981014h-7.9829396c-1.1092806 0-2.0085302-.8867064-2.0085302-1.9981014v-2.0018986h-1.00491071c-1.10185739 0-1.99508929-.8874333-1.99508929-1.999615v-6.00077002c0-1.10435686.8926228-1.99961498 1.99508929-1.99961498h1.00491071v-2.00208688c0-1.10341695.90195036-1.99791312 2.0085302-1.99791312h7.9829396c1.1092806 0 2.0085302.89826062 2.0085302 1.99791312v2.00208688h1.0049107c1.1018574 0 1.9950893.88743329 1.9950893 1.99961498v6.00077002c0 1.1043569-.8926228 1.999615-1.9950893 1.999615zm-1-3h-10v5.0018986c0 .5546075.44702548.9981014 1.0085302.9981014h7.9829396c.5565964 0 1.0085302-.4491701 1.0085302-.9981014zm-9 1h8v1h-8zm0 2h5v1h-5zm9-5c-.5522847 0-1-.44771525-1-1s.4477153-1 1-1 1 .44771525 1 1-.4477153 1-1 1z" fill-rule="evenodd"/></symbol><symbol id="icon-search" viewBox="0 0 22 22"><path d="M21.697 20.261a1.028 1.028 0 01.01 1.448 1.034 1.034 0 01-1.448-.01l-4.267-4.267A9.812 9.811 0 010 9.812a9.812 9.811 0 1117.43 6.182zM9.812 18.222A8.41 8.41 0 109.81 1.403a8.41 8.41 0 000 16.82z" fill-rule="evenodd"/></symbol><symbol id="icon-social-facebook" viewBox="0 0 24 24"><path d="m6.00368507 20c-1.10660471 0-2.00368507-.8945138-2.00368507-1.9940603v-12.01187942c0-1.10128908.89451376-1.99406028 1.99406028-1.99406028h12.01187942c1.1012891 0 1.9940603.89451376 1.9940603 1.99406028v12.01187942c0 1.1012891-.88679 1.9940603-2.0032184 1.9940603h-2.9570132v-6.1960818h2.0797387l.3114113-2.414723h-2.39115v-1.54164807c0-.69911803.1941355-1.1755439 1.1966615-1.1755439l1.2786739-.00055875v-2.15974763l-.2339477-.02492088c-.3441234-.03134957-.9500153-.07025255-1.6293054-.07025255-1.8435726 0-3.1057323 1.12531866-3.1057323 3.19187953v1.78079225h-2.0850778v2.414723h2.0850778v6.1960818z" fill-rule="evenodd"/></symbol><symbol id="icon-social-twitter" viewBox="0 0 24 24"><path d="m18.8767135 6.87445248c.7638174-.46908424 1.351611-1.21167363 1.6250764-2.09636345-.7135248.43394112-1.50406.74870123-2.3464594.91677702-.6695189-.73342162-1.6297913-1.19486605-2.6922204-1.19486605-2.0399895 0-3.6933555 1.69603749-3.6933555 3.78628909 0 .29642457.0314329.58673729.0942985.8617704-3.06469922-.15890802-5.78835241-1.66547825-7.60988389-3.9574208-.3174714.56076194-.49978171 1.21167363-.49978171 1.90536824 0 1.31404706.65223085 2.47224203 1.64236444 3.15218497-.60350999-.0198635-1.17401554-.1925232-1.67222562-.47366811v.04583885c0 1.83355406 1.27302891 3.36609966 2.96411421 3.71294696-.31118484.0886217-.63651445.1329326-.97441718.1329326-.2357461 0-.47149219-.0229194-.69466516-.0672303.47149219 1.5065703 1.83253297 2.6036468 3.44975116 2.632678-1.2651707 1.0160946-2.85724264 1.6196394-4.5891906 1.6196394-.29861172 0-.59093688-.0152796-.88011875-.0504227 1.63450624 1.0726291 3.57548241 1.6990934 5.66104951 1.6990934 6.79263079 0 10.50641749-5.7711113 10.50641749-10.7751859l-.0094298-.48894775c.7229547-.53478659 1.3516109-1.20250585 1.8419628-1.96190282-.6632323.30100846-1.3751855.50422736-2.1217148.59590507z" fill-rule="evenodd"/></symbol><symbol id="icon-social-youtube" viewBox="0 0 24 24"><path d="m10.1415 14.3973208-.0005625-5.19318431 4.863375 2.60554491zm9.963-7.92753362c-.6845625-.73643756-1.4518125-.73990314-1.803375-.7826454-2.518875-.18714178-6.2971875-.18714178-6.2971875-.18714178-.007875 0-3.7861875 0-6.3050625.18714178-.352125.04274226-1.1188125.04620784-1.8039375.7826454-.5394375.56084773-.7149375 1.8344515-.7149375 1.8344515s-.18 1.49597903-.18 2.99138042v1.4024082c0 1.495979.18 2.9913804.18 2.9913804s.1755 1.2736038.7149375 1.8344515c.685125.7364376 1.5845625.7133337 1.9850625.7901542 1.44.1420891 6.12.1859866 6.12.1859866s3.78225-.005776 6.301125-.1929178c.3515625-.0433198 1.1188125-.0467854 1.803375-.783223.5394375-.5608477.7155-1.8344515.7155-1.8344515s.18-1.4954014.18-2.9913804v-1.4024082c0-1.49540139-.18-2.99138042-.18-2.99138042s-.1760625-1.27360377-.7155-1.8344515z" fill-rule="evenodd"/></symbol><symbol id="icon-subject-medicine" viewBox="0 0 18 18"><path d="m12.5 8h-6.5c-1.65685425 0-3 1.34314575-3 3v1c0 1.6568542 1.34314575 3 3 3h1v-2h-.5c-.82842712 0-1.5-.6715729-1.5-1.5s.67157288-1.5 1.5-1.5h1.5 2 1 2c1.6568542 0 3-1.34314575 3-3v-1c0-1.65685425-1.3431458-3-3-3h-2v2h1.5c.8284271 0 1.5.67157288 1.5 1.5s-.6715729 1.5-1.5 1.5zm-5.5-1v-1h-3.5c-1.38071187 0-2.5-1.11928813-2.5-2.5s1.11928813-2.5 2.5-2.5h1.02786405c.46573528 0 .92507448.10843528 1.34164078.31671843l1.13382424.56691212c.06026365-1.05041141.93116291-1.88363055 1.99667093-1.88363055 1.1045695 0 2 .8954305 2 2h2c2.209139 0 4 1.790861 4 4v1c0 2.209139-1.790861 4-4 4h-2v1h2c1.1045695 0 2 .8954305 2 2s-.8954305 2-2 2h-2c0 1.1045695-.8954305 2-2 2s-2-.8954305-2-2h-1c-2.209139 0-4-1.790861-4-4v-1c0-2.209139 1.790861-4 4-4zm0-2v-2.05652691c-.14564246-.03538148-.28733393-.08714006-.42229124-.15461871l-1.15541752-.57770876c-.27771087-.13885544-.583937-.21114562-.89442719-.21114562h-1.02786405c-.82842712 0-1.5.67157288-1.5 1.5s.67157288 1.5 1.5 1.5zm4 1v1h1.5c.2761424 0 .5-.22385763.5-.5s-.2238576-.5-.5-.5zm-1 1v-5c0-.55228475-.44771525-1-1-1s-1 .44771525-1 1v5zm-2 4v5c0 .5522847.44771525 1 1 1s1-.4477153 1-1v-5zm3 2v2h2c.5522847 0 1-.4477153 1-1s-.4477153-1-1-1zm-4-1v-1h-.5c-.27614237 0-.5.2238576-.5.5s.22385763.5.5.5zm-3.5-9h1c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-1c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5z" fill-rule="evenodd"/></symbol><symbol id="icon-success" viewBox="0 0 18 18"><path d="m9 0c4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9zm3.4860198 4.98163161-4.71802968 5.50657859-2.62834168-2.02300024c-.42862421-.36730544-1.06564993-.30775346-1.42283677.13301307-.35718685.44076653-.29927542 1.0958383.12934879 1.46314377l3.40735508 2.7323063c.42215801.3385221 1.03700951.2798252 1.38749189-.1324571l5.38450527-6.33394549c.3613513-.43716226.3096573-1.09278382-.115462-1.46437175-.4251192-.37158792-1.0626796-.31842941-1.4240309.11873285z" fill-rule="evenodd"/></symbol><symbol id="icon-table" viewBox="0 0 18 18"><path d="m16.0049107 2c1.1018574 0 1.9950893.89706013 1.9950893 2.00585866v9.98828264c0 1.1078052-.8926228 2.0058587-1.9950893 2.0058587l-4.0059107-.001.001.001h-1l-.001-.001h-5l.001.001h-1l-.001-.001-3.00391071.001c-1.10185739 0-1.99508929-.8970601-1.99508929-2.0058587v-9.98828264c0-1.10780515.8926228-2.00585866 1.99508929-2.00585866zm-11.0059107 5h-3.999v6.9941413c0 .5572961.44630695 1.0058587.99508929 1.0058587h3.00391071zm6 0h-5v8h5zm5.0059107-4h-4.0059107v3h5.001v1h-5.001v7.999l4.0059107.001c.5487152 0 .9950893-.4488783.9950893-1.0058587v-9.98828264c0-.55729607-.446307-1.00585866-.9950893-1.00585866zm-12.5049107 9c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-1c-.27614237 0-.5-.2238576-.5-.5s.22385763-.5.5-.5zm12 0c.2761424 0 .5.2238576.5.5s-.2238576.5-.5.5h-2c-.2761424 0-.5-.2238576-.5-.5s.2238576-.5.5-.5zm-6 0c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-2c-.27614237 0-.5-.2238576-.5-.5s.22385763-.5.5-.5zm-6-2c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-1c-.27614237 0-.5-.2238576-.5-.5s.22385763-.5.5-.5zm12 0c.2761424 0 .5.2238576.5.5s-.2238576.5-.5.5h-2c-.2761424 0-.5-.2238576-.5-.5s.2238576-.5.5-.5zm-6 0c.27614237 0 .5.2238576.5.5s-.22385763.5-.5.5h-2c-.27614237 0-.5-.2238576-.5-.5s.22385763-.5.5-.5zm-6-2c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-1c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5zm12 0c.2761424 0 .5.22385763.5.5s-.2238576.5-.5.5h-2c-.2761424 0-.5-.22385763-.5-.5s.2238576-.5.5-.5zm-6 0c.27614237 0 .5.22385763.5.5s-.22385763.5-.5.5h-2c-.27614237 0-.5-.22385763-.5-.5s.22385763-.5.5-.5zm1.499-5h-5v3h5zm-6 0h-3.00391071c-.54871518 0-.99508929.44887827-.99508929 1.00585866v1.99414134h3.999z" fill-rule="evenodd"/></symbol><symbol id="icon-tick-circle" viewBox="0 0 24 24"><path d="m12 2c5.5228475 0 10 4.4771525 10 10s-4.4771525 10-10 10-10-4.4771525-10-10 4.4771525-10 10-10zm0 1c-4.97056275 0-9 4.02943725-9 9 0 4.9705627 4.02943725 9 9 9 4.9705627 0 9-4.0294373 9-9 0-4.97056275-4.0294373-9-9-9zm4.2199868 5.36606669c.3613514-.43716226.9989118-.49032077 1.424031-.11873285s.4768133 1.02720949.115462 1.46437175l-6.093335 6.94397871c-.3622945.4128716-.9897871.4562317-1.4054264.0971157l-3.89719065-3.3672071c-.42862421-.3673054-.48653564-1.0223772-.1293488-1.4631437s.99421256-.5003185 1.42283677-.1330131l3.11097438 2.6987741z" fill-rule="evenodd"/></symbol><symbol id="icon-tick" viewBox="0 0 16 16"><path d="m6.76799012 9.21106946-3.1109744-2.58349728c-.42862421-.35161617-1.06564993-.29460792-1.42283677.12733148s-.29927541 1.04903009.1293488 1.40064626l3.91576307 3.23873978c.41034319.3393961 1.01467563.2976897 1.37450571-.0948578l6.10568327-6.660841c.3613513-.41848908.3096572-1.04610608-.115462-1.4018218-.4251192-.35571573-1.0626796-.30482786-1.424031.11366122z" fill-rule="evenodd"/></symbol><symbol id="icon-update" viewBox="0 0 18 18"><path d="m1 13v1c0 .5522847.44771525 1 1 1h14c.5522847 0 1-.4477153 1-1v-1h-1v-10h-14v10zm16-1h1v2c0 1.1045695-.8954305 2-2 2h-14c-1.1045695 0-2-.8954305-2-2v-2h1v-9c0-.55228475.44771525-1 1-1h14c.5522847 0 1 .44771525 1 1zm-1 0v1h-4.5857864l-1 1h-2.82842716l-1-1h-4.58578644v-1h5l1 1h2l1-1zm-13-8h12v7h-12zm1 1v5h10v-5zm1 1h4v1h-4zm0 2h4v1h-4z" fill-rule="evenodd"/></symbol><symbol id="icon-upload" viewBox="0 0 18 18"><path d="m10.0046024 0c.5497429 0 1.3179837.32258606 1.707238.71184039l4.5763192 4.57631922c.3931386.39313859.7118404 1.16760135.7118404 1.71431368v8.98899651c0 1.1092806-.8945138 2.0085302-1.9940603 2.0085302h-12.01187942c-1.10128908 0-1.99406028-.8926228-1.99406028-1.9950893v-14.00982141c0-1.10185739.88743329-1.99508929 1.99961498-1.99508929zm0 1h-7.00498742c-.55709576 0-.99961498.44271433-.99961498.99508929v14.00982141c0 .5500396.44491393.9950893.99406028.9950893h12.01187942c.5463747 0 .9940603-.4506622.9940603-1.0085302v-8.98899651c0-.28393444-.2150684-.80332809-.4189472-1.0072069l-4.5763192-4.57631922c-.2038461-.20384606-.718603-.41894717-1.0001312-.41894717zm-1.85576936 4.14572769c.19483374-.19483375.51177826-.19377714.70556874.00001334l2.59099082 2.59099079c.1948411.19484112.1904373.51514474.0027906.70279143-.1932998.19329987-.5046517.19237083-.7001856-.00692852l-1.74638687-1.7800176v6.14827687c0 .2717771-.23193359.492096-.5.492096-.27614237 0-.5-.216372-.5-.492096v-6.14827641l-1.74627892 1.77990922c-.1933927.1971171-.51252214.19455839-.70016883.0069117-.19329987-.19329988-.19100584-.50899493.00277731-.70277808z" fill-rule="evenodd"/></symbol><symbol id="icon-video" viewBox="0 0 18 18"><path d="m16.0049107 2c1.1018574 0 1.9950893.89706013 1.9950893 2.00585866v9.98828264c0 1.1078052-.8926228 2.0058587-1.9950893 2.0058587h-14.00982141c-1.10185739 0-1.99508929-.8970601-1.99508929-2.0058587v-9.98828264c0-1.10780515.8926228-2.00585866 1.99508929-2.00585866zm0 1h-14.00982141c-.54871518 0-.99508929.44887827-.99508929 1.00585866v9.98828264c0 .5572961.44630695 1.0058587.99508929 1.0058587h14.00982141c.5487152 0 .9950893-.4488783.9950893-1.0058587v-9.98828264c0-.55729607-.446307-1.00585866-.9950893-1.00585866zm-8.30912922 2.24944486 4.60460462 2.73982242c.9365543.55726659.9290753 1.46522435 0 2.01804082l-4.60460462 2.7398224c-.93655425.5572666-1.69578148.1645632-1.69578148-.8937585v-5.71016863c0-1.05087579.76670616-1.446575 1.69578148-.89375851zm-.67492769.96085624v5.5750128c0 .2995102-.10753745.2442517.16578928.0847713l4.58452283-2.67497259c.3050619-.17799716.3051624-.21655446 0-.39461026l-4.58452283-2.67497264c-.26630747-.15538481-.16578928-.20699944-.16578928.08477139z" fill-rule="evenodd"/></symbol><symbol id="icon-warning" viewBox="0 0 18 18"><path d="m9 11.75c.69035594 0 1.25.5596441 1.25 1.25s-.55964406 1.25-1.25 1.25-1.25-.5596441-1.25-1.25.55964406-1.25 1.25-1.25zm.41320045-7.75c.55228475 0 1.00000005.44771525 1.00000005 1l-.0034543.08304548-.3333333 4c-.043191.51829212-.47645714.91695452-.99654578.91695452h-.15973424c-.52008864 0-.95335475-.3986624-.99654576-.91695452l-.33333333-4c-.04586475-.55037702.36312325-1.03372649.91350028-1.07959124l.04148683-.00259031zm-.41320045 14c-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9 4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9z" fill-rule="evenodd"/></symbol><symbol id="icon-checklist-banner" viewBox="0 0 56.69 56.69"><path style="fill:none" d="M0 0h56.69v56.69H0z"/><clipPath id="b"><use xlink:href="#a" style="overflow:visible"/></clipPath><path d="M21.14 34.46c0-6.77 5.48-12.26 12.24-12.26s12.24 5.49 12.24 12.26-5.48 12.26-12.24 12.26c-6.76-.01-12.24-5.49-12.24-12.26zm19.33 10.66 10.23 9.22s1.21 1.09 2.3-.12l2.09-2.32s1.09-1.21-.12-2.3l-10.23-9.22m-19.29-5.92c0-4.38 3.55-7.94 7.93-7.94s7.93 3.55 7.93 7.94c0 4.38-3.55 7.94-7.93 7.94-4.38-.01-7.93-3.56-7.93-7.94zm17.58 12.99 4.14-4.81" style="clip-path:url(#b);fill:none;stroke:#01324b;stroke-width:2;stroke-linecap:round"/><path d="M8.26 9.75H28.6M8.26 15.98H28.6m-20.34 6.2h12.5m14.42-5.2V4.86s0-2.93-2.93-2.93H4.13s-2.93 0-2.93 2.93v37.57s0 2.93 2.93 2.93h15.01M8.26 9.75H28.6M8.26 15.98H28.6m-20.34 6.2h12.5" style="clip-path:url(#b);fill:none;stroke:#01324b;stroke-width:2;stroke-linecap:round;stroke-linejoin:round"/></symbol><symbol id="icon-chevron-down" viewBox="0 0 16 16"><path d="m5.58578644 3-3.29289322-3.29289322c-.39052429-.39052429-.39052429-1.02368927 0-1.41421356s1.02368927-.39052429 1.41421356 0l4 4c.39052429.39052429.39052429 1.02368927 0 1.41421356l-4 4c-.39052429.39052429-1.02368927.39052429-1.41421356 0s-.39052429-1.02368927 0-1.41421356z" fill-rule="evenodd" transform="matrix(0 1 -1 0 11 1)"/></symbol><symbol id="icon-eds-i-arrow-right-medium" viewBox="0 0 24 24"><path d="m12.728 3.293 7.98 7.99a.996.996 0 0 1 .281.561l.011.157c0 .32-.15.605-.384.788l-7.908 7.918a1 1 0 0 1-1.416-1.414L17.576 13H4a1 1 0 0 1 0-2h13.598l-6.285-6.293a1 1 0 0 1-.082-1.32l.083-.095a1 1 0 0 1 1.414.001Z"/></symbol><symbol id="icon-eds-i-chevron-down-medium" viewBox="0 0 16 16"><path d="m2.00087166 7h4.99912834v-4.99912834c0-.55276616.44386482-1.00087166 1-1.00087166.55228475 0 1 .44463086 1 1.00087166v4.99912834h4.9991283c.5527662 0 1.0008717.44386482 1.0008717 1 0 .55228475-.4446309 1-1.0008717 1h-4.9991283v4.9991283c0 .5527662-.44386482 1.0008717-1 1.0008717-.55228475 0-1-.4446309-1-1.0008717v-4.9991283h-4.99912834c-.55276616 0-1.00087166-.44386482-1.00087166-1 0-.55228475.44463086-1 1.00087166-1z" fill-rule="evenodd"/></symbol><symbol id="icon-eds-i-chevron-down-small" viewBox="0 0 16 16"><path d="M13.692 5.278a1 1 0 0 1 .03 1.414L9.103 11.51a1.491 1.491 0 0 1-2.188.019L2.278 6.692a1 1 0 0 1 1.444-1.384L8 9.771l4.278-4.463a1 1 0 0 1 1.318-.111l.096.081Z"/></symbol><symbol id="icon-eds-i-chevron-right-medium" viewBox="0 0 10 10"><path d="m5.96738168 4.70639573 2.39518594-2.41447274c.37913917-.38219212.98637524-.38972225 1.35419292-.01894278.37750606.38054586.37784436.99719163-.00013556 1.37821513l-4.03074001 4.06319683c-.37758093.38062133-.98937525.38100976-1.367372-.00003075l-4.03091981-4.06337806c-.37759778-.38063832-.38381821-.99150444-.01600053-1.3622839.37750607-.38054587.98772445-.38240057 1.37006824.00302197l2.39538588 2.4146743.96295325.98624457z" fill-rule="evenodd" transform="matrix(0 -1 1 0 0 10)"/></symbol><symbol id="icon-eds-i-chevron-right-small" viewBox="0 0 10 10"><path d="m5.96738168 4.70639573 2.39518594-2.41447274c.37913917-.38219212.98637524-.38972225 1.35419292-.01894278.37750606.38054586.37784436.99719163-.00013556 1.37821513l-4.03074001 4.06319683c-.37758093.38062133-.98937525.38100976-1.367372-.00003075l-4.03091981-4.06337806c-.37759778-.38063832-.38381821-.99150444-.01600053-1.3622839.37750607-.38054587.98772445-.38240057 1.37006824.00302197l2.39538588 2.4146743.96295325.98624457z" fill-rule="evenodd" transform="matrix(0 -1 1 0 0 10)"/></symbol><symbol id="icon-eds-i-chevron-up-medium" viewBox="0 0 16 16"><path d="m2.00087166 7h11.99825664c.5527662 0 1.0008717.44386482 1.0008717 1 0 .55228475-.4446309 1-1.0008717 1h-11.99825664c-.55276616 0-1.00087166-.44386482-1.00087166-1 0-.55228475.44463086-1 1.00087166-1z" fill-rule="evenodd"/></symbol><symbol id="icon-eds-i-close-medium" viewBox="0 0 16 16"><path d="m2.29679575 12.2772478c-.39658757.3965876-.39438847 1.0328109-.00062148 1.4265779.39651227.3965123 1.03246768.3934888 1.42657791-.0006214l4.27724782-4.27724787 4.2772478 4.27724787c.3965876.3965875 1.0328109.3943884 1.4265779.0006214.3965123-.3965122.3934888-1.0324677-.0006214-1.4265779l-4.27724787-4.2772478 4.27724787-4.27724782c.3965875-.39658757.3943884-1.03281091.0006214-1.42657791-.3965122-.39651226-1.0324677-.39348875-1.4265779.00062148l-4.2772478 4.27724782-4.27724782-4.27724782c-.39658757-.39658757-1.03281091-.39438847-1.42657791-.00062148-.39651226.39651227-.39348875 1.03246768.00062148 1.42657791l4.27724782 4.27724782z" fill-rule="evenodd"/></symbol><symbol id="icon-eds-i-download-medium" viewBox="0 0 16 16"><path d="m12.9975267 12.999368c.5467123 0 1.0024733.4478567 1.0024733 1.000316 0 .5563109-.4488226 1.000316-1.0024733 1.000316h-9.99505341c-.54671233 0-1.00247329-.4478567-1.00247329-1.000316 0-.5563109.44882258-1.000316 1.00247329-1.000316zm-4.9975267-11.999368c.55228475 0 1 .44497754 1 .99589209v6.80214418l2.4816273-2.48241149c.3928222-.39294628 1.0219732-.4006883 1.4030652-.01947579.3911302.39125371.3914806 1.02525073-.0001404 1.41699553l-4.17620792 4.17752758c-.39120769.3913313-1.02508144.3917306-1.41671995-.0000316l-4.17639421-4.17771394c-.39122513-.39134876-.39767006-1.01940351-.01657797-1.40061601.39113012-.39125372 1.02337105-.3931606 1.41951349.00310701l2.48183446 2.48261871v-6.80214418c0-.55001601.44386482-.99589209 1-.99589209z" fill-rule="evenodd"/></symbol><symbol id="icon-eds-i-info-filled-medium" viewBox="0 0 18 18"><path d="m9 0c4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9zm0 7h-1.5l-.11662113.00672773c-.49733868.05776511-.88337887.48043643-.88337887.99327227 0 .47338693.32893365.86994729.77070917.97358929l.1126697.01968298.11662113.00672773h.5v3h-.5l-.11662113.0067277c-.42082504.0488782-.76196299.3590206-.85696816.7639815l-.01968298.1126697-.00672773.1166211.00672773.1166211c.04887817.4208251.35902055.761963.76398144.8569682l.1126697.019683.11662113.0067277h3l.1166211-.0067277c.4973387-.0577651.8833789-.4804365.8833789-.9932723 0-.4733869-.3289337-.8699473-.7707092-.9735893l-.1126697-.019683-.1166211-.0067277h-.5v-4l-.00672773-.11662113c-.04887817-.42082504-.35902055-.76196299-.76398144-.85696816l-.1126697-.01968298zm0-3.25c-.69035594 0-1.25.55964406-1.25 1.25s.55964406 1.25 1.25 1.25 1.25-.55964406 1.25-1.25-.55964406-1.25-1.25-1.25z" fill-rule="evenodd"/></symbol><symbol id="icon-eds-i-mail-medium" viewBox="0 0 24 24"><path d="m19.462 0c1.413 0 2.538 1.184 2.538 2.619v12.762c0 1.435-1.125 2.619-2.538 2.619h-16.924c-1.413 0-2.538-1.184-2.538-2.619v-12.762c0-1.435 1.125-2.619 2.538-2.619zm.538 5.158-7.378 6.258a2.549 2.549 0 0 1 -3.253-.008l-7.369-6.248v10.222c0 .353.253.619.538.619h16.924c.285 0 .538-.266.538-.619zm-.538-3.158h-16.924c-.264 0-.5.228-.534.542l8.65 7.334c.2.165.492.165.684.007l8.656-7.342-.001-.025c-.044-.3-.274-.516-.531-.516z"/></symbol><symbol id="icon-eds-i-menu-medium" viewBox="0 0 24 24"><path d="M21 4a1 1 0 0 1 0 2H3a1 1 0 1 1 0-2h18Zm-4 7a1 1 0 0 1 0 2H3a1 1 0 0 1 0-2h14Zm4 7a1 1 0 0 1 0 2H3a1 1 0 0 1 0-2h18Z"/></symbol><symbol id="icon-eds-i-search-medium" viewBox="0 0 24 24"><path d="M11 1c5.523 0 10 4.477 10 10 0 2.4-.846 4.604-2.256 6.328l3.963 3.965a1 1 0 0 1-1.414 1.414l-3.965-3.963A9.959 9.959 0 0 1 11 21C5.477 21 1 16.523 1 11S5.477 1 11 1Zm0 2a8 8 0 1 0 0 16 8 8 0 0 0 0-16Z"/></symbol><symbol id="icon-eds-i-user-single-medium" viewBox="0 0 24 24"><path d="M12 1a5 5 0 1 1 0 10 5 5 0 0 1 0-10Zm0 2a3 3 0 1 0 0 6 3 3 0 0 0 0-6Zm-.406 9.008a8.965 8.965 0 0 1 6.596 2.494A9.161 9.161 0 0 1 21 21.025V22a1 1 0 0 1-1 1H4a1 1 0 0 1-1-1v-.985c.05-4.825 3.815-8.777 8.594-9.007Zm.39 1.992-.299.006c-3.63.175-6.518 3.127-6.678 6.775L5 21h13.998l-.009-.268a7.157 7.157 0 0 0-1.97-4.573l-.214-.213A6.967 6.967 0 0 0 11.984 14Z"/></symbol><symbol id="icon-eds-i-warning-filled-medium" viewBox="0 0 18 18"><path d="m9 11.75c.69035594 0 1.25.5596441 1.25 1.25s-.55964406 1.25-1.25 1.25-1.25-.5596441-1.25-1.25.55964406-1.25 1.25-1.25zm.41320045-7.75c.55228475 0 1.00000005.44771525 1.00000005 1l-.0034543.08304548-.3333333 4c-.043191.51829212-.47645714.91695452-.99654578.91695452h-.15973424c-.52008864 0-.95335475-.3986624-.99654576-.91695452l-.33333333-4c-.04586475-.55037702.36312325-1.03372649.91350028-1.07959124l.04148683-.00259031zm-.41320045 14c-4.97056275 0-9-4.0294373-9-9 0-4.97056275 4.02943725-9 9-9 4.9705627 0 9 4.02943725 9 9 0 4.9705627-4.0294373 9-9 9z" fill-rule="evenodd"/></symbol><symbol id="icon-expand-image" viewBox="0 0 18 18"><path d="m7.49754099 11.9178212c.38955542-.3895554.38761957-1.0207846-.00290473-1.4113089-.39324695-.3932469-1.02238878-.3918247-1.41130883-.0029047l-4.10273549 4.1027355.00055454-3.5103985c.00008852-.5603185-.44832171-1.006032-1.00155062-1.0059446-.53903074.0000852-.97857527.4487442-.97866268 1.0021075l-.00093318 5.9072465c-.00008751.553948.44841131 1.001882 1.00174994 1.0017946l5.906983-.0009331c.5539233-.0000875 1.00197907-.4486389 1.00206646-1.0018679.00008515-.5390307-.45026621-.9784332-1.00588841-.9783454l-3.51010549.0005545zm3.00571741-5.83449376c-.3895554.38955541-.3876196 1.02078454.0029047 1.41130883.393247.39324696 1.0223888.39182478 1.4113089.00290473l4.1027355-4.10273549-.0005546 3.5103985c-.0000885.56031852.4483217 1.006032 1.0015506 1.00594461.5390308-.00008516.9785753-.44874418.9786627-1.00210749l.0009332-5.9072465c.0000875-.553948-.4484113-1.00188204-1.0017499-1.00179463l-5.906983.00093313c-.5539233.00008751-1.0019791.44863892-1.0020665 1.00186784-.0000852.53903074.4502662.97843325 1.0058884.97834547l3.5101055-.00055449z" fill-rule="evenodd"/></symbol><symbol id="icon-github" viewBox="0 0 100 100"><path fill-rule="evenodd" clip-rule="evenodd" d="M48.854 0C21.839 0 0 22 0 49.217c0 21.756 13.993 40.172 33.405 46.69 2.427.49 3.316-1.059 3.316-2.362 0-1.141-.08-5.052-.08-9.127-13.59 2.934-16.42-5.867-16.42-5.867-2.184-5.704-5.42-7.17-5.42-7.17-4.448-3.015.324-3.015.324-3.015 4.934.326 7.523 5.052 7.523 5.052 4.367 7.496 11.404 5.378 14.235 4.074.404-3.178 1.699-5.378 3.074-6.6-10.839-1.141-22.243-5.378-22.243-24.283 0-5.378 1.94-9.778 5.014-13.2-.485-1.222-2.184-6.275.486-13.038 0 0 4.125-1.304 13.426 5.052a46.97 46.97 0 0 1 12.214-1.63c4.125 0 8.33.571 12.213 1.63 9.302-6.356 13.427-5.052 13.427-5.052 2.67 6.763.97 11.816.485 13.038 3.155 3.422 5.015 7.822 5.015 13.2 0 18.905-11.404 23.06-22.324 24.283 1.78 1.548 3.316 4.481 3.316 9.126 0 6.6-.08 11.897-.08 13.526 0 1.304.89 2.853 3.316 2.364 19.412-6.52 33.405-24.935 33.405-46.691C97.707 22 75.788 0 48.854 0z"/></symbol><symbol id="icon-springer-arrow-left"><path d="M15 7a1 1 0 000-2H3.385l2.482-2.482a.994.994 0 00.02-1.403 1.001 1.001 0 00-1.417 0L.294 5.292a1.001 1.001 0 000 1.416l4.176 4.177a.991.991 0 001.4.016 1 1 0 00-.003-1.42L3.385 7H15z"/></symbol><symbol id="icon-springer-arrow-right"><path d="M1 7a1 1 0 010-2h11.615l-2.482-2.482a.994.994 0 01-.02-1.403 1.001 1.001 0 011.417 0l4.176 4.177a1.001 1.001 0 010 1.416l-4.176 4.177a.991.991 0 01-1.4.016 1 1 0 01.003-1.42L12.615 7H1z"/></symbol><symbol id="icon-submit-open" viewBox="0 0 16 17"><path d="M12 0c1.10457 0 2 .895431 2 2v5c0 .276142-.223858.5-.5.5S13 7.276142 13 7V2c0-.512836-.38604-.935507-.883379-.993272L12 1H6v3c0 1.10457-.89543 2-2 2H1v8c0 .512836.38604.935507.883379.993272L2 15h6.5c.276142 0 .5.223858.5.5s-.223858.5-.5.5H2c-1.104569 0-2-.89543-2-2V5.828427c0-.530433.210714-1.039141.585786-1.414213L4.414214.585786C4.789286.210714 5.297994 0 5.828427 0H12Zm3.41 11.14c.250899.250899.250274.659726 0 .91-.242954.242954-.649606.245216-.9-.01l-1.863671-1.900337.001043 5.869492c0 .356992-.289839.637138-.647372.637138-.347077 0-.647371-.285256-.647371-.637138l-.001043-5.869492L9.5 12.04c-.253166.258042-.649726.260274-.9.01-.242954-.242954-.252269-.657731 0-.91l2.942184-2.951303c.250908-.250909.66127-.252277.91353-.000017L15.41 11.14ZM5 1.413 1.413 5H4c.552285 0 1-.447715 1-1V1.413ZM11 3c.276142 0 .5.223858.5.5s-.223858.5-.5.5H7.5c-.276142 0-.5-.223858-.5-.5s.223858-.5.5-.5H11Zm0 2c.276142 0 .5.223858.5.5s-.223858.5-.5.5H7.5c-.276142 0-.5-.223858-.5-.5s.223858-.5.5-.5H11Z" fill-rule="nonzero"/></symbol></svg> </div> </body> </html>