Accelerating Development of Better PTSD Treatment for Veterans: The VA PTSD Psychopharmacology Initiative (PPI)

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href="/resources/ORD_Admin/default.cfm">Admin Resources Home</a></li> <li><a href="/resources/ORD_Admin/ord_contacts.cfm">Central Office Contacts</a></li> <li><a href="/resources/ORD_Admin/clinical_trials.cfm">Clinical Trials Registration and Submission</a></li> <li><a href="/resources/ORD_Admin/congressional_info.cfm">Congressional Requests</a></li> <li><a href="/resources/ORD_Admin/field_conference.cfm">Field Conference Calls</a></li> <li><a href="/resources/frac/default.cfm">Field Research Advisory Committee</a></li> </ul> </li> </ul> </nav> </div>   <div id="left-col-content"> </div>   </div>   <div id="innerContentWrapper" style="position: relative; "> <div class="clear"></div> <span style="position:absolute;"><a name="main-content" id="main-content"></a></span> <div class="clear"></div> <div id="tier4innerContent" style="border:0px solid green;">  <h2 class="page-title">Accelerating Development of Better PTSD Treatment for Veterans: The VA PTSD Psychopharmacology Initiative (PPI) </h2>  <p align="right">| <a href="default.cfm">CSR&D Home </a>| </p> <p>Since 2016, VA Research has been working to support the development of new medication treatments through focused clinical trials under our PTSD Psychopharmacology Initiative (PPI). While there are two FDA approved medications for PTSD (both antidepressants), not everyone successfully tolerates or responds to those medications, and thus our clinical trials program has grown to accommodate multiple ongoing studies (described below).  It is the goal of the PPI to identify, test, and confirm new effective medications that could become available for PTSD treatments.</p> <p>In this effort we still need investigators to:</p> <ol> <li><strong>Evaluate local interest</strong> in serving as a performance sites for PTSD medication studies. Researchers who wish to serve as site investigators should notify their Research Office and assist with the completion of the <a href="PPI_Survey_Fillable.pdf" target="_blank">PPI Site Survey</a>.</li> </ol> <ol start="2"> <li><strong>Conduct research on new compounds</strong>. We encourage eligible VA investigators who are interested in testing new medications for PTSD in Veterans to apply for funding through the CSR&D Clinical Trials program.  The first step in this process is to submit a Clinical Trial letter of intent.  Instructions and deadlines can be found in <a href="/isrm/shared_docs/resources.cfm#4">Section IV of our Resources For the VA Research Community</a> </li> </ol> <p>The PPI is an integral part of the Clinical Science Research and Development (CSRD) roadmap, <a href="CSRD_Roadmap.pdf" target="_blank">Accelerating the Translation of New Medications for Veterans with PTSD</a>. This document illustrates our progress to date as well as future goals related to this important effort.</p> <p>Questions regarding PPI may be submitted to <u><a href="mailto:CLIN-Review@va.gov">CLIN-Review@va.gov</a></u>.</p> <h4> Active/Completed PTSD Medication Studies</h4> <table> <tbody> <tr> <td width="151"> <p><strong>PI Name</strong></p> </td> <td width="366"> <p><strong>Title</strong></p> </td> <td width="121"> <p><strong>Station</strong></p> </td> </tr> <tr> <td width="151"> <p>Ayers, Catherine</p> </td> <td width="366"> <p>Cannabidiol as an adjunctive to prolonged exposure for the treatment of PTSD</p> </td> <td width="121"> <p>San Diego, CA</p> </td> </tr> <tr> <td width="151"> <p>Back, Sudie</p> </td> <td width="366"> <p>CAP – Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders</p> </td> <td width="121"> <p>Charleston, SC</p> </td> </tr> <tr> <td width="151"> <p>Flanagan, Julianne</p> </td> <td width="366"> <p>Enhancing Prolonged Exposure Therapy for PTSD with Oxytocin</p> </td> <td width="121"> <p>Charleston, SC</p> </td> </tr> <tr> <td width="151"> <p>Hendrickson, Rebecca</p> </td> <td width="366"> <p>Noradrenergic biomarkers in PTSD: precision medicine & mechanisms</p> </td> <td width="121"> <p>Seattle, WA</p> </td> </tr> <tr> <td width="151"> <p>Inslicht, Sabra</p> </td> <td width="366"> <p>Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Post-Traumatic Stress</p> </td> <td width="121"> <p>San Francisco, CA</p> </td> </tr> <tr> <td width="151"> <p>Jones, Melissa</p> </td> <td width="366"> <p>Pimavanserin for Insomnia in Veterans with Post-traumatic Stress Disorder</p> </td> <td width="121"> <p>Houston, TX</p> </td> </tr> <tr> <td width="151"> <p>Krystal, John</p> </td> <td width="366"> <p>CAP – Ketamine for antidepressant resistant PTSD</p> </td> <td width="121"> <p>West Haven, CT</p> </td> </tr> <tr> <td width="151"> <p>Lin, Chen</p> </td> <td width="366"> <p>A randomized placebo-controlled trail of methylphenidate in Veterans with a diagnosis of post traumatic stress disorder and recent cerebral stroke</p> </td> <td width="121"> <p>Birmingham, AL</p> </td> </tr> <tr> <td width="151"> <p>Naylor, Jennifer</p> </td> <td width="366"> <p>Neurosteroid Intervention for PTSD in Iraq/Afghanistan-era Veterans</p> </td> <td width="121"> <p>Durham, NC</p> </td> </tr> <tr> <td width="151"> <p>Neylan, Thomas</p> </td> <td width="366"> <p>Phase IIa Trial of a Selective Glucocorticoid Receptor Antagonist in the Treatment of Veterans with Posttraumatic Stress Disorder (PTSD)</p> </td> <td width="121"> <p>San Francisco, CA</p> </td> </tr> <tr> <td width="151"> <p>Norman, Sonya</p> </td> <td width="366"> <p>Topiramate and Prolonged Exposure for Alcohol Use Disorder and PTSD</p> </td> <td width="121"> <p>San Diego, CA</p> </td> </tr> <tr> <td width="151"> <p> Raskind, Murray<br> Davis, Lori </p> </td> <td width="366"> <p>Randomized Placebo-Controlled Trial of Methylphenidate for the Treatment of Post-Traumatic Stress Disorder with Associated Neurocognitive Complaints</p> </td> <td width="121"> <p>Seattle, WA Tuscaloosa, AL</p> </td> </tr> <tr> <td width="151"> <p>Shiroma, Paulo</p> </td> <td width="366"> <p>Repeated Ketamine Treatment to Accelerate Efficacy of Prolonged Exposure in PTSD</p> </td> <td width="121"> <p>Minneapolis, MN</p> </td> </tr> </tbody> </table> <div class="clear"></div> </div>   <br style="clear: both" /> <br clear="all">  <div style="bottom:0; margin-left:30px; margin-top:30px; font-weight:bold; padding-top:10px; border-top:1px solid #cccccc;" id="footerBlock"> Questions about the R&D website? <a href="mailto:HSRDWeb.Boston@va.gov" style="color:#0B6CB2 !Important;">Email the Web Team</a> <span style="font-size:10px; font-weight:normal;"> <br> <br> Any health information on this website is strictly for informational purposes and is not intended as medical advice. 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Accelerating Development of Better PTSD Treatment for Veterans: The VA PTSD Psychopharmacology Initiative (PPI)