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Q&A with Silvia Crescioli, Business Intelligence Creator, The Antibody Society
<!doctype html><html lang="en"><head> <meta charset="utf-8"> <title>Q&A with Silvia Crescioli, Business Intelligence Creator, The Antibody Society</title> <link rel="shortcut icon" href="https://oxfordglobal.com/hubfs/OXFORD_GLOBAL-LOGO_SYMBOL.jpg"> <meta name="description" content="We catch up with Silvia Crescioli from The Antibody Society to unpack the latest trends and technologies fuelling progress in antibody therapeutic development"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta property="og:description" content="We catch up with Silvia Crescioli from The Antibody Society to unpack the latest trends and technologies fuelling progress in antibody therapeutic development"> <meta property="og:title" content="Q&A with Silvia Crescioli, Business Intelligence Creator, The Antibody Society"> <meta name="twitter:description" content="We catch up with Silvia Crescioli from The Antibody Society to unpack the latest trends and technologies fuelling progress in antibody therapeutic development"> <meta name="twitter:title" content="Q&A with Silvia Crescioli, Business Intelligence Creator, The Antibody Society"> <style> a.cta_button{-moz-box-sizing:content-box !important;-webkit-box-sizing:content-box !important;box-sizing:content-box !important;vertical-align:middle}.hs-breadcrumb-menu{list-style-type:none;margin:0px 0px 0px 0px;padding:0px 0px 0px 0px}.hs-breadcrumb-menu-item{float:left;padding:10px 0px 10px 10px}.hs-breadcrumb-menu-divider:before{content:'›';padding-left:10px}.hs-featured-image-link{border:0}.hs-featured-image{float:right;margin:0 0 20px 20px;max-width:50%}@media (max-width: 568px){.hs-featured-image{float:none;margin:0;width:100%;max-width:100%}}.hs-screen-reader-text{clip:rect(1px, 1px, 1px, 1px);height:1px;overflow:hidden;position:absolute !important;width:1px} </style> <link rel="stylesheet" href="https://oxfordglobal.com/hs-fs/hub/8696823/hub_generated/template_assets/135726131582/1732113079147/git/og-stage/css/main.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/fontawesome.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/brands.min.css"> <link rel="stylesheet" href="https://cdn.oxfordglobal.com/fontawesome/6.5.1/css/solid.min.css"> <!-- Editor Styles --> <style id="hs_editor_style" type="text/css"> #hs_cos_wrapper_module_17019620504109 { display: block !important; margin-bottom: 0px !important } </style> <!-- Added by GoogleAnalytics4 integration --> <script> var _hsp = window._hsp = window._hsp || []; window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} var useGoogleConsentModeV2 = true; var waitForUpdateMillis = 1000; if (!window._hsGoogleConsentRunOnce) { window._hsGoogleConsentRunOnce = true; gtag('consent', 'default', { 'ad_storage': 'denied', 'analytics_storage': 'denied', 'ad_user_data': 'denied', 'ad_personalization': 'denied', 'wait_for_update': waitForUpdateMillis }); if (useGoogleConsentModeV2) { _hsp.push(['useGoogleConsentModeV2']) } else { _hsp.push(['addPrivacyConsentListener', function(consent){ var hasAnalyticsConsent = consent && (consent.allowed || (consent.categories && consent.categories.analytics)); var hasAdsConsent = consent && (consent.allowed || (consent.categories && consent.categories.advertisement)); gtag('consent', 'update', { 'ad_storage': hasAdsConsent ? 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Antibody Society Interview" style="position: absolute; top: 0px; left: 0px; width: 100%; height: 100%; border: none;"></iframe></div></div></div> <p> </p> <h1>Q&A Summary</h1> <h2 aria-level="1"><span data-contrast="none">What stood out for you as particularly notable or impactful?</span><span data-ccp-props="{"134245418":true,"134245529":true,"335551550":1,"335551620":1,"335559738":40,"335559739":0}"> </span></h2> <p><span data-contrast="auto">Crescioli particularly enjoyed talks about early discovery and clinical advancement of antibody therapeutics. Crescioli found the workshop on the FC mediated effect of function profiling “engaging and insightful.” </span><span data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> <p><span data-contrast="auto">Noting the balance of industry, academic, and service provider attendees, Crescioli said: “I believe bringing together these two worlds is becoming more important due to the rapid progress of the field.” The agenda was designed to allow plenty of time for networking: “crucial for both the attendees’ professional growth and to foster collaborations and progress in the field.”</span><span data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> <h2 aria-level="1"><span data-contrast="none">What key trends are you observing in the antibody industry?</span><span data-ccp-props="{"134245418":true,"134245529":true,"335551550":1,"335551620":1,"335559738":40,"335559739":0}"> </span></h2> <p><span data-contrast="auto">The Antibody Society studies trends in the global antibody therapeutic clinical pipeline by continuously collecting data. Crescioli said that since 2010, they’ve noticed an increase in enhanced medical antibodies like bispecifics and ADCs entering the clinic. Furthermore, the Society has also noticed an increase in canonical monospecific antibodies and immunomodulatory molecules in the clinic.</span><span data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> <p><span data-contrast="auto">With this increase over the past five years, the Society have tracked trends in the types of targets, formats, and ADC payloads. Of particular note are combinations of these properties like bispecific ADCs or bispecifics with immunomodulatory properties.</span><span data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> <h2 aria-level="1"><span data-contrast="none">What are the biggest challenges, how do you see them being addressed in the near future?</span><span data-ccp-props="{"134245418":true,"134245529":true,"335551550":1,"335551620":1,"335559738":40,"335559739":0}"> </span></h2> <p><span data-contrast="auto">Crescioli said that the complexity and variety of antibody formats that have arisen from advances in antibody engineering techniques over the past decade has led to the biggest challenges for the industry at the moment. </span><span data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> <p><span data-contrast="auto">Because of this, antibody designers will need to avoid unexpected efficacy and safety issues. Therefore, understanding the relevant biology is more important than ever when designing the next generation of therapeutic antibodies. This means understanding targets in their physiological and pathological context and designing the antibody to complement that.</span><span data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> <p><span data-contrast="auto">Crescioli also mentioned antibody developability, which includes work in basic biology and preclinical assessment. “To do so, collaborations between academia and industry, as well as between scientists from different backgrounds: from biologists to chemists to clinicians to bioinformaticians, will be crucial. I believe that conferences like this one are a great forum for allow this to happen.”</span><span data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> <h2 aria-level="1"><span data-contrast="none">Have there been any recent regulatory actions relating to antibody development that you’re aware of?</span><span data-ccp-props="{"134245418":true,"134245529":true,"335551550":1,"335551620":1,"335559738":40,"335559739":0}"> </span></h2> <p><span data-contrast="auto">Crescioli said that the Antibody Society has noticed an increase in Complete Response Letters (CRLs) issued by the FDA in the past five years. In particular, they noticed an increase in CRLs were due to CMC concerns. </span><span data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> <p><span data-contrast="auto">CRLs are issued by the FDA regarding concerns with a marketing application – and they can delay approval by the authority by six months or more. Therefore, Crescioli noted that this highlights the need to be proactive and ensure that the manufacturing sites meet the FDA requirements for Good Manufacturing Practice (GMP).</span><span data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> <h2 aria-level="1"><span data-contrast="none">What are you excited to discuss at next year’s NextGen Biomed conference?</span><span data-ccp-props="{"134245418":true,"134245529":true,"335551550":1,"335551620":1,"335559738":40,"335559739":0}"> </span></h2> <p><span data-contrast="auto">At NextGen Biomed 2025 in March, Crescioli will provide an overview of the current commercial antibody therapeutic clinical pipeline. Her presentation will provide updates on antibodies in regulatory review and those which have recently been approved. </span><span data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> <p><span data-contrast="auto">This includes the Antibody Society’s analysis of the trends in terms of targets, formats, and characteristics of antibody therapeutics. Crescioli will cover next generation and unconventional ADCs, bi- and multi specific antibodies, and immunomodulatory antibodies. “I’m very happy to have the opportunity to present these results, and I look forward to NextGen Biomed in 2025.”</span><span data-ccp-props="{"335551550":6,"335551620":6}"> </span></p> <div class="content-body-footer"> </div> </div> <div class="content-sidebar"> <div class="related-event"> <h3 class="center">Related Events</h3> For more on this topic, you may be interested in our upcoming <a href="/nextgen-biomed/events/nextgen-biomed-2025">NextGen Biomed 2025</a> </div> <div class="related-articles"> <h3 class="center">Related Resources</h3> <div class="article"> <a href="/nextgen-biomed/resources/case-studies/accelerating-biologics-discovery-and-development"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Biologics/Antibodies%20Case%20Study%20Report%20Websize.jpg" class="cover-graphic-image"> </div> </a><div 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