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Quali sono le forme principali?" /> <meta name="viewport" content="width=device-width, initial-scale=1.0, minimum-scale=1.0, maximum-scale=1.0, user-scalable=no" /> <meta name="robots" content="all, max-image-preview:large" /> <meta http-equiv="origin-trial" content="AlNunJ6X2eiWMKc5eQeEp1M74m8SmnwoZtOh/hDFSX5HUMoq5IzG2Z1LIEITU8FZDWN1w4X5fkp4dlknRSysKggAAAB6eyJvcmlnaW4iOiJodHRwczovL215LXBlcnNvbmFsdHJhaW5lci5pdDo0NDMiLCJmZWF0dXJlIjoiTG9uZ0FuaW1hdGlvbkZyYW1lVGltaW5nIiwiZXhwaXJ5IjoxNzE2OTQwNzk5LCJpc1N1YmRvbWFpbiI6dHJ1ZX0="> <meta property="og:title" content="Fibrosi" /> <meta property="og:type" content="website" /> <meta property="og:url" content="https://www.my-personaltrainer.it/salute/fibrosi.html" /> <meta property="og:image" content="https://www.my-personaltrainer.it/salute/img3/fibrosi-polmonare.jpg" /> <meta property="og:description" content="Cos'è la fibrosi? Quali sono le cause? Quali organi e tessuti colpisce? Quali sono le forme principali? Fibrosi è il nome che i medici usano per indicare l'anomala formazione di tessuto connettivo-fibroso in un organo o in un tessuto del corpo umano, senza particolari accenni al comportamento del tessuto parenchimale. In un organo o in un tessuto, la fibrosi può derivare da uno stato patologico oppure può essere il risultato del processo di cicatrizzazione..." /> <link rel="canonical" href="https://www.my-personaltrainer.it/salute/fibrosi.html" /> <link rel="alternate" media="only screen and (max-width: 800px)" href="https://m.my-personaltrainer.it/salute/fibrosi.html"> <link rel="alternate" type="application/rss+xml" title="My-personaltrainer.it Feed" href="https://feeds.feedburner.com/My-personaltrainer/" /> <link rel="dns-prefetch preconnect" href="https://securepubads.g.doubleclick.net"> <link rel="dns-prefetch preconnect" href="https://www.googletagservices.com"> <link rel="dns-prefetch preconnect" href="https://adv.mediamond.it"> <link rel="dns-prefetch preconnect" href="https://ptp.stbm.it"> <link rel="dns-prefetch preconnect" href="https://cdn.iubenda.com"> <link rel="preload" href="https://dafne.sirio.stbm.it/utility-fe/prod/general/network.common.v3.js" as="script"> <link rel="preload" 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Antonio Griguolo">Dott. Antonio Griguolo</a></span> </div> </div> </div> </header> <div class="sal-inner sal-leaf-content barlow sal-mBottom4x"> <div class="sal-leaf-accessori sal-leaf-accessori-top sal-mBottom2x"> <div class="sal-leaf-accessori-lastmod barlow">Ultima modifica <date>12.03.2020</date></div> <div class="sal-leaf-accessori-sharebox"> <a href="mailto:?subject=Desidero%20condividere%20questo%20articolo%20con%20te&body=Leggi qui: Fibrosi - https://www.my-personaltrainer.it/salute/fibrosi.html" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareMAIL" data-action="email"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="/css/images/icons.svg#foglia-shareMAIL" /> </svg> </span> </a> <a href="javascript:void(window.open('http://www.facebook.com/sharer/sharer.php?u=https://www.my-personaltrainer.it/salute/fibrosi.html','MYP-shareFB','width=600,height=400'));" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareFB" data-action="facebook"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="/css/images/icons.svg#foglia-shareFB" /> </svg> </span> </a> <a href="javascript:void(window.open('https://twitter.com/intent/tweet?url=https://www.my-personaltrainer.it/salute/fibrosi.html&text=Fibrosi','MYP-shareTW','width=600,height=400'));" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareTW" data-action="twitter"> <span class="sal-icon"> <svg viewBox="0 0 28 28" style="padding: 5px;"> <use xlink:href="/css/images/icons.svg#foglia-shareTW" /> </svg> </span> </a> <a href="whatsapp://send?text=Leggi qui: Fibrosi - https://www.my-personaltrainer.it/salute/fibrosi.html" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareWA sal-hide-desktop" data-action="whatsapp"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="/css/images/icons.svg#foglia-shareWA" /> </svg> </span> </a> </div> </div> <div class="sal-adv-slot amePlaceholderBox sal-honcode sal-mBottom5x sal-hide-desktop"><div class="sal-adv-gpt" id="adv-gpt-box-mobile-container1"></div></div> <div id="toc-hook"> <div class="sal-widget-section sal-legacy sal-mBottom5x"> <a id="503971"></a> <div id="lista"><nav><a title="Generalità" href="#1">Generalità</a><a title="Cos'è la fibrosi?" href="#2">Cos'è la fibrosi?</a><a title="Esempi" href="#3">Esempi</a><a title="Fibrosi polmonare" href="#4">Fibrosi polmonare</a><a title="Fibrosi Cardiaca" href="#5">Fibrosi Cardiaca</a><a title="Morbo di Dupuytren" href="#6">Morbo di Dupuytren</a><a title="Malattia di Peyronie" href="#7">Malattia di Peyronie</a><a title="Artrofibrosi" href="#8">Artrofibrosi</a><a title="Mielofibrosi" href="#9">Mielofibrosi</a><a title="Fibrosi cistica" href="#10">Fibrosi cistica</a><a title="Fibrosi retroperitoneale" href="#11">Fibrosi retroperitoneale</a><a title="Fibrosi Nefrogenica Sistemica" href="#12">Fibrosi Nefrogenica Sistemica</a></nav></div><a name="1"></a><section class="lst 1dv"><h2 style="margin-top:0">Generalità</h2> <p><strong>Fibrosi</strong> è il nome che i medici usano per indicare l'<strong>anomala formazione di tessuto <a href="/fisiologia/tessuto-connettivo-cosa-e-funzioni-e-classificazione.html" title="Tessuto connettivo: cosa è, funzioni e classificazione">connettivo</a>-fibroso</strong> in un organo o in un tessuto del <a href="/salute-benessere/corpo-umano.html">corpo umano</a>, senza particolari accenni al comportamento del tessuto parenchimale.<br> <img src="img3/fibrosi-polmonare.jpg" width="310" height="364" alt="fibrosi polmonare" class="imgright">In un organo o in un tessuto, la fibrosi può derivare da uno stato patologico, oppure può essere il risultato del processo di <a href="/erboristeria/cicatrizzanti.html">cicatrizzazione</a> che si mette in moto a seguito di una lesione, un taglio o un danno a carico di una struttura anatomica del corpo.<br> Esistono numerosi tipi di fibrosi. Tra i tipi più noti e comuni, si segnalano: la <a href="/salute-benessere/fibrosi-polmonare.html">fibrosi polmonare</a>, la fibrosi cardiaca, l'artrofibrosi, il <a href="/salute-benessere/malattia-di-dupuytren.html">morbo di Dupuytren</a>, la <a href="/salute/fibrosi-cistica.html">fibrosi cistica</a>, la <a href="/salute-benessere/malattia-di-peyronie.html">malattia di Peyronie</a>, la gliosi, la fibrosi nefrogenica sistemica ecc.</p> <h3>Breve ripasso del significato di parenchima e tessuto fibroso</h3> <p>In ambito medico, il termine “<strong>parenchima</strong>” identifica il tessuto che conferisce a un certo organo le sue caratteristiche funzionali specifiche. Per capire tale affermazione, è utile riportare un paio di esempi:</p> <ul> <li>Il parenchima del cuore è l'insieme dei <a href="/fisiologia/muscolo-cardiaco.html">miociti del miocardio</a>;</li> <li>Il parenchima dei <a href="/fisiologia/polmoni.html" title="Polmoni">polmoni</a> comprende il tessuto alveolare, le <a href="https://www.my-personaltrainer.it/biologia/cellula-eucariote-caratteristiche.html" title="Cellula eucariote: caratteristiche e differenze dai procarioti">cellule</a> costituenti i <a href="/fisiologia/bronchi-bronchioli.html">bronchioli</a>, le cellule che compongono i dotti alveolari, il cosiddetto interstizio ecc.</li> </ul> <p>Di contro, il termine “<strong>tessuto fibroso</strong>” e il suo sinonimo “<strong>tessuto connettivo-fibroso</strong>” indicano un tessuto privo di funzione, composto da un ammasso di <strong>fibre</strong> <strong>collagene</strong>.<br> La formazione di tessuto connettivo-fibroso è dovuta a un'iperattività di alcune cellule particolari, appartenenti al cosiddetto <strong>tessuto connettivo</strong> e note col nome di <strong><a href="/fisiologia/derma.html">fibroblasti</a></strong>.</p></section><a name="2"></a><section class="lst 2dv"><h2>Cos'è la fibrosi?</h2> <p><strong>Fibrosi</strong> è il termine medico che identifica l'anomala formazione di ingenti quantità di tessuto connettivo-fibroso in un organo, in una porzione di un organo oppure in un particolare tessuto del corpo, <strong>senza alcun riferimento al comportamento del parenchima</strong>.<br> I processi di fibrosi alterano l'architettura e, conseguentemente, anche la funzione dell'organo o del tessuto che colpiscono.<br> La fibrosi può essere il risultato di uno stato patologico, che comporta la deposizione insolita di tessuto connettivo-fibroso (<strong>fibrosi patologica</strong>), oppure può essere l'effetto dei normali meccanismi di cicatrizzazione, che s'innescano in un organo o in un tessuto, in occasione della guarigione da una lesione o un danno (<strong>fibrosi cicatriziale</strong>). </p> <h3>Tessuto connettivo-fibroso e tessuto cicatriziale: sono la stessa cosa?</h3> <p>Il <strong>tessuto cicatriziale</strong> che si può osservare, dopo la guarigione di un taglio profondo sulla <a href="/fisiologia/pelle-disidratazione.html">cute</a>, è un esempio di tessuto connettivo-fibroso.<br> Pertanto, tessuto cicatriziale, tessuto fibroso e tessuto connettivo-fibroso sono tre modi diversi per identificare la stessa cosa.<br> In genere, la dicitura “tessuto cicatriziale” trova impiego quando la formazione del tessuto connettivo-fibroso è dipendente dalla cicatrizzazione di una lesione.</p> <h3>Fibrosi e <a href="/benessere/fibroma.html" title="Fibroma">fibroma</a></h3> <p>Un <strong>fibroma</strong> è un tumore benigno composto dalle stesse cellule che costituiscono il <strong>tessuto connettivo fibroso</strong>.<br> I fibromi risultano da particolari processi di fibrosi.<br> Le condizioni mediche che si caratterizzano per la presenza di uno o più fibromi prendono il nome di <strong><a href="/salute/fibromatosi.html">fibromatosi</a></strong>.</p> <h3>Fibrosi, sclerosi e cirrosi: le differenze</h3> <p>È un errore confondere la fibrosi con la <strong>sclerosi</strong> e la <strong>cirrosi</strong>. Questi tre processi, infatti, si assomigliano, ma non sono affatto la stessa cosa. Ricordando che con fibrosi ci si riferisce alla comparsa spropositata di tessuto cicatriziale senza alcun riferimento al parenchima, di seguito sono riportati i significati di <a href="/salute-benessere/sclerosi.html">sclerosi</a> e <a href="/Articoli/Cirrosi.html">cirrosi</a>:</p> <ul> <li><u>Con il termine di sclerosi</u>, i medici indicano l'indurimento di un organo o di una sua parte considerevole, dovuto alla neoformazione di tessuto connettivo-fibroso e alla contemporanea regressione del normale parenchima. In altre parole, quando è vittima di sclerosi, un organo o un tessuto vede diminuire la propria componente parenchimale (ossia la componente <a href="/allenamento/allenamento-funzionale-motivi.html" title="Allenamento funzionale: cosa c’è di vero?">funzionale</a>) e aumentare in modo anomalo la componente connettiva-fibrosa.<br> Un esempio di sclerosi è l'<strong><a href="/salute/arteriosclerosi-aterosclerosi.html">arteriosclerosi</a></strong>.</li> <li><u>Con il termine di cirrosi</u>, invece, i medici intendono un aumento del tessuto connettivo-fibroso in un organo o in una sua parte, associato a una riduzione del tessuto parenchimale e a tentativi, da parte di quest'ultimo, di rigenerarsi.<br> Un esempio di cirrosi è la <strong><a href="/fegato/cirrosi.html" title="Cirrosi Epatica: cos’è? Sintomi, cause e cura">cirrosi epatica</a></strong>.</li> </ul></section><a name="3"></a><section class="lst 3dv"><h2>Esempi</h2> <p>Il processo di fibrosi può avere sede in vari organi o tessuti del corpo umano.<br> Per esempio, può interessare: i polmoni, <a href="/cuore.htm" title="Cuore: Com’è Fatto e Come Funziona?">il cuore</a>, il <a href="/fisiologia/pancreas.html" title="Pancreas: Cos'è? A Cosa Serve e Come Funziona">pancreas</a>, alcune cellule particolari del <a href="/fisiologia/sistema-nervoso-centrale.html">sistema nervoso centrale</a>, le <a href="/fisiologia/articolazioni.html" title="Articolazioni">articolazioni</a> più importanti, le <a href="/salute-benessere/mano.html">mani</a>, la <a href="/fisiologia/pelle.html">pelle</a>, il mediastino, gli <a href="/salute/anatomia-fisiologia-occhio.html">occhi</a>, il <a href="/fisiologia/pene.html" title="Pene">pene</a>, il retroperitoneo e il <a href="/fisiologia/midollo-osseo.html" title="Midollo Osseo">midollo osseo</a>.</p> <h3>Forme più note di fibrosi</h3> <p>Le forme più note di fibrosi sono:</p> <ul> <li>La <strong>fibrosi polmonare</strong> e le malattie che potrebbero precederla, come l'<strong><a href="/salute-benessere/interstiziopatia.html">interstiziopatia polmonare</a></strong> e la <strong><a href="/salute-benessere/pneumoconiosi.html">pneumoconiosi</a></strong>;</li> <li>La <strong>fibrosi cardiaca</strong>;</li> <li>Il <strong>morbo di Dupuytren</strong>;</li> <li>La <strong>malattia di Peyronie</strong>;</li> <li>L'<strong>artrofibrosi</strong>;</li> <li>La <strong><a href="/salute-benessere/mielofibrosi.html">mielofibrosi</a></strong>;</li> <li>La <strong>fibrosi cistica</strong>;</li> <li>La <strong>fibrosi retroperitoneale</strong>;</li> <li>La <strong>fibrosi nefrogenica sistemica</strong>;</li> <li>La <strong>gliosi</strong>;</li> <li>I <strong><a href="/benessere/cheloidi.html">cheloidi</a></strong>;</li> <li>La <strong>fibrosi mediastinica</strong>;</li> <li>La <strong><a href="/spalla-congelata.html">capsulite adesiva</a> della spalla</strong>.</li> </ul> </section><a name="4"></a><section class="lst 4dv"><h2>Fibrosi polmonare</h2> <p>La fibrosi polmonare è una malattia respiratoria, che insorge a causa della comparsa di tessuto connettivo-fibroso sui <strong>polmoni</strong>, per la precisione tutt'attorno agli <strong><a href="/fisiologia/alveoli-polmonari.html">alveoli polmonari</a></strong>, cioè i fautori del prelievo dell'ossigeno dall'<a href="/fisiologia/composizione-aria.html">aria inspirata</a>.<br> I polmoni delle persone con fibrosi polmonare sono poco elastici, duri e ricoperti di cicatrici retraenti, le quali “stritolano” gli alveoli, impedendone la normale funzione e ostacolando il processo di <a href="/respirazione_addominale.htm">respirazione</a>.<br> Nella fibrosi polmonare, la formazione del tessuto connettivo-fibroso può dipendere da fattori irriconoscibili, non identificabili; oppure può dipendere da fattori ben specifici, quali per esempio: la prolungata esposizione a sostanze tossiche, la <a href="/salute-benessere/radioterapia.html" title="Radioterapia: come funziona, tipologie ed effetti collaterali">radioterapia</a> antitumorale, l'uso di farmaci <a href="/salute-benessere/farmaci-chemioterapici.html">chemioterapici</a>, alcune <a href="/salute-benessere/malattie-autoimmuni.html">malattie autoimmuni</a> o alcune <a href="/salute/malattie-infettive.html">malattie infettive</a>.<br> Se le cause non sono identificabili, si parla più correttamente di <strong><a href="/salute-benessere/fibrosi-polmonare-idiopatica.html" title="Fibrosi Polmonare Idiopatica">fibrosi polmonare idiopatica</a></strong>; se invece le cause sono circostanze riconoscibili, si parla più propriamente di <strong>fibrosi polmonare secondaria</strong>.<br> I <a href="/Sintomi/Fibrosi_polmonare">sintomi tipici della fibrosi polmonare</a> sono: <a href="/Sintomi/Dispnea">dispnea</a>, <a href="/benessere/tosse-secca.html" title="Tosse Secca: Cos'è, Cause, Rimedi e Cure">tosse secca</a>, senso ricorrente di <a href="/allenamento/fatica-e-overreaching-nello-sport-cause-come-si-manifesta-e-come-recuperare.html" title="Fatica e overreaching nello sport: cause, come si manifesta e come recuperare">fatica</a> e debolezza, <a href="/Sintomi/Perdita-di-peso">perdita di peso</a> senza motivo, <a href="/Sintomi/Dolore-al-petto">dolore al torace</a> e <a href="/salute/dolore-muscolare-mialgia.html" title="Dolore Muscolare (Mialgia)">dolori muscolari</a> e articolari.<br> La diagnosi richiede un iter di <a href="/salute/esami.html">esami</a> abbastanza lungo.<br> Purtroppo, è pressoché impossibile guarire dalla fibrosi polmonare. Il tessuto connettivo-fibroso, infatti, ha carattere permanente e, per eliminarlo, bisognerebbe ricorrere al difficile e pericoloso intervento di <strong><a href="/bpco/trapianto-polmone.html">trapianto di polmone</a></strong>.<br> Pertanto, le uniche cure attualmente disponibili sono terapie con l'obiettivo di alleviare la sintomatologia e migliorare, per quanto possibile, la qualità della vita dei pazienti.</p> </section><a name="5"></a><section class="lst 5dv"><h2>Fibrosi Cardiaca</h2> <p>Nota anche come <strong>fibrosi miocardica</strong>, la fibrosi cardiaca è l'affezione del cuore che si caratterizza per la presenza di tessuto connettivo-fibroso a livello del <strong>miocardio</strong>.<br> In genere, nella fibrosi cardiaca, il tessuto cicatriziale compare a causa di sofferenza cardiovascolare (es: <a href="/ipertensione/ipertensione.html" title="Ipertensione o Pressione Alta: cause, sintomi e come abbassarla">ipertensione</a>, <a href="/fisiologia/coronarie.html" title="Coronarie e Coronaropatia">coronaropatia</a>, <a href="/cardiopatia-ischemica/infarto.html">infarto del miocardio</a> ecc.).<br> Chi soffre di fibrosi cardiaca presenta un cuore in cui la muscolatura è più rigida e meno <a href="/fisiologia/come-avviene-la-contrazione-muscolare.html" title="Come avviene la contrazione muscolare?">contrattile</a> e in cui le <a href="/salute/valvole-cardiache.html" title="Valvole Cardiache">valvole cardiache</a> sono meno efficienti. Ciò ha ovviamente un effetto negativo sulla funzione di pompa del <a href="/Sangue.htm">sangue</a>, svolta dall'organo interessato.<br> Responsabile di dispnea, <a href="/tosse.html" title="Tosse">tosse</a> persistente, <a href="/benessere/spossatezza.html" title="Stanchezza e Spossatezza: Cosa Sono, Cause, Rimedi">stanchezza</a> ricorrente, perdita di <a href="/peso-forma.html" title="Peso Forma: Calcolare il Peso Ideale">peso</a> ecc., la fibrosi cardiaca può portare all'instaurarsi di uno stato di <strong><a href="/salute-benessere/insufficienza-cardiaca.html">insufficienza cardiaca</a></strong>.<br> Purtroppo, non esistono cure capaci di ripristinare la normale architettura del miocardio; gli unici trattamenti di cui possono disporre i pazienti, hanno il potere di alleviare la sintomatologia e rallentare la progressione dell'insufficienza cardiaca, quando s'instaura.</p> </section><a name="6"></a><section class="lst 6dv"><h2>Morbo di Dupuytren</h2> <p>Conosciuto anche come <strong><a href="/contrattura-muscolare.html" title="Contrattura Muscolare">contrattura</a> di Dupuytren</strong>, il morbo di Dupuytren è una patologia a carico della mano, che si caratterizza per un processo di fibrosi a carico della cosiddetta <strong>aponeurosi palmare</strong> e per la conseguente curvatura permanente di uno o più dita in direzione del palmo.<br> Chi soffre di morbo di Dupuytren, oltre a presentare una o più dita ricurve verso il palmo, lamenta: </p> <ul> <li>La presenza di uno o più noduli in corrispondenza dei tendini delle <a href="/salute-benessere/dita-mano.html" title="Dita della Mano: Cosa e Quali Sono? Anatomia, Funzione e Patologie principali">dita della mano</a>. Questi noduli sono fibromi, pertanto dipendono dal processo di fibrosi;</li> <li><a href="/farmacologia/cura-dolore-63.html">Dolore</a>, <a href="/Sintomi/Prurito">prurito</a> e/o indolenzimento in corrispondenza del palmo della mano;</li> <li>Difficoltà a impugnare gli oggetti e a svolgere numerose attività che richiedono l'impiego delle mani (es: guidare, suonare uno strumento musicale, tenere in mano le posate ecc.).</li> </ul> <p>La diagnosi di morbo di Dupuytren è semplice, in quanto i <a href="/segni_o_sintomi.php">segni</a> sono inequivocabili.<br> La scelta terapeutica per la cura del morbo di Dupuytren è assai ampia: esistono, infatti, <strong>trattamenti non-chirurgici</strong>, come la radioterapia e le iniezioni di <a href="/farmaci/xiapex.html">collagenasi</a> di <em>Clostridium histolyticum</em>, e <strong>trattamenti chirurgici</strong> dalla variabile invasività, come la fasciotomia percutanea con ago, la fasciotomia palmare e la fascectomia.<br> L'adozione di un trattamento piuttosto che un altro dipende esclusivamente dalla gravità della sintomatologia e da ciò che è emerso durante la diagnosi.</p> <br><div class="dietetica"> <p>Il morbo di Dupuytren è una forma di fibromatosi, denominata <strong>fibromatosi palmare</strong>. </p> </div><br> </section><a name="7"></a><section class="lst 7dv"><h2>Malattia di Peyronie</h2> <p>In ambito medico, il termine “malattia di Peyronie” indica un'anomala curvatura del pene, evidenziabile soprattutto durante le <a href="/fisiologia/erezione-pene.html">erezioni</a>, che è dovuta alla formazione di tessuto connettivo-fibroso all'interno dei corpi cavernosi.<br> Conosciuta anche come <strong><em>induratio penis plastica</em></strong> e considerata tra le principali cause di <strong><a href="/Sintomi/Pene_curvo">pene curvo</a></strong>, la malattia di Peyronie è spesso associata a: dolore al pene (specialmente durante le erezioni), presenza di un'insolita protuberanza sul pene rilevabile al tatto, <a href="/salute/disfunzione-erettile.html" title="Disfunzione Erettile">problemi di erezione</a> e <a href="/Sintomi/Riduzione_dimensioni_pene">riduzione delle dimensioni del pene</a>.</p><br> <img src="img3/malattia-di-peyronie.jpg" width="450" height="247" alt="malattia di peyronie" class="imgcenter"><br> <p>I precisi fattori scatenanti la malattia di Peyronie sono pochi chiari; secondo la maggior parte degli esperti, la malformazione in questione sarebbe il risultato di uno o più <a href="/traumatismi.html">traumi</a> al pene.<br> Questi traumi al pene possono avere luogo durante i rapporti sessuali oppure in occasione di incidenti stradali, infortuni sul posto di lavoro, infortuni sportivi o scontri fortuiti con altre persone od oggetti.<br> La diagnosi della malattia di Peyronie è abbastanza semplice, in quanto i segni clinici sono inequivocabili.<br> La scelta del trattamento terapeutico più adeguato dipende dalla gravità della malattia: per i casi meno gravi, si consiglia un trattamento farmacologico; mentre, per i casi più gravi, serve un intervento chirurgico.</p> </section><a name="8"></a><section class="lst 8dv"><h2>Artrofibrosi</h2> <p>L'artrofibrosi è la fibrosi delle articolazioni, risultante quasi sempre da traumi a loro carico.<br> Le articolazioni vittime di artrofibrosi perdono parte della loro mobilità, sono dolorose e gonfie, e non adempiono più alle loro funzioni fisiologiche.<br> Tra le articolazioni più soggette ad artrofibrosi, rientrano: il <a href="/traumatologia-ortopedia/ginocchio.html" title="Ginocchio: Com'è Fatto e Quali Funzioni svolge?">ginocchio</a>, la spalla, l'<a href="https://www.my-personaltrainer.it/salute/riabilitazione-dopo-la-protesi-all-anca.html" title="https://www.my-personaltrainer.it/salute/riabilitazione-dopo-la-protesi-all-anca.html">anca</a>, la <a href="/salute-benessere/caviglia.html">caviglia</a>, il <a href="/fisiologia/polso.html">polso</a> e gli elementi articolari che contraddistinguono la <a href="/traumatologia-ortopedia/ipercifosi.html">colonna vertebrale</a>.<br> A seconda della gravità dell'artrofibrosi, il trattamento può essere conservativo oppure chirurgico: è conservativo per i casi meno severi, mentre è chirurgico per le circostanze più gravi o che non rispondono alla terapia conservativa.<br> In genere, il trattamento conservativo comprende: la fisioterapia, la somministrazione di <a href="/salute/infiammazione-fans.html">FANS</a> contro il dolore, la <a href="/benessere/crioterapia.html">crioterapia</a> e le iniezioni di <a href="/salute/cortisonici.html" title="Cortisonici: cosa sono e a cosa servono?">corticosteroidi</a>.<br> Il trattamento chirurgico, invece, consiste in un intervento di <strong>adesiolisi</strong>. </p> </section><a name="9"></a><section class="lst 9dv"><h2>Mielofibrosi</h2> <p>La mielofibrosi è un grave <a href="/salute-benessere/cancro.html">tumore maligno</a> del <strong>midollo osseo</strong>, che altera il processo di ematopoiesi al punto da ridurre, in modo drastico, i livelli di <a href="/fisiologia/globuli-rossi.html">globuli rossi</a>, <a href="/fisiologia/leucociti.html" title="Leucociti o Globuli Bianchi: Cosa Sono, Valori e Funzioni">globuli bianchi</a> e <a href="/salute/piastrine.html">piastrine</a>, presenti nel sangue. <br> Rientra tra le forme di fibrosi, in quanto, in sua presenza, si assiste a una progressiva sostituzione del midollo osseo malato con tessuto connettivo-fibroso.<br> Dalle cause ancora poco chiare, la mielofibrosi provoca <strong><a href="/salute/anemie.html" title="Anemia: sintomi, cause, quando preoccuparsi e trattamento">anemia</a></strong>, <strong><a href="/salute/leucopenia.html">leucopenia</a></strong> e <strong><a href="/benessere/piastrinopenia.html" title="Piastrinopenia: cosa significa? Valori, sintomi e cause di piastrine basse">trombocitopenia</a></strong>; queste tre condizioni sono responsabili di numerosi sintomi, tra cui: stanchezza e debolezza croniche, <a href="/Sintomi/Fiato_corto">fiato corto</a>, <a href="/salute/milza-ingrossata.html">splenomegalia</a>, <a href="/Sintomi/Epatomegalia">epatomegalia</a>, <a href="/Sintomi/Pallore">pallore della pelle</a>, <a href="/gengive-sanguinanti.html" title="Gengive che Sanguinano">facilità al sanguinamento</a>, <a href="/Sintomi/Sudorazioni-notturne">sudorazione notturna</a>, <a href="/febbre.html" title="Febbre">febbre</a>, infezioni ricorrenti e <a href="/Sintomi/Dolore-alle-ossa">dolore alle ossa</a>.<br> Guarire dalla mielofibrosi è possibile, ma serve un <strong><a href="/salute-benessere/trapianto-di-midollo-osseo.html">trapianto di midollo osseo</a></strong>, un trattamento ad alto rischio per il paziente e dal successo incerto.<br> Per questo motivo, i medici hanno messo a punto soluzioni alternative, che sebbene non permettano di raggiungere la guarigione, sono comunque molto efficaci nel moderare i sintomi e nel migliorare la qualità della vita dei pazienti.</p> </section><a name="10"></a><section class="lst 10dv"><h2>Fibrosi cistica</h2> <p>La fibrosi cistica è una grave malattia ereditaria, in presenza della quale si assiste a un'<a href="/asma/catarro.html">iperproduzione di muco</a> anomalo (più denso, più viscoso e meno scorrevole), da parte delle <a href="/salute-benessere/ghiandole-esocrine.html" title="Ghiandole Esocrine">ghiandole esocrine</a> come il pancreas, le <a href="/fisiologia/saliva.html">ghiandole salivari</a>, le <a href="/fisiologia/sudorazione.html">ghiandole sudoripare</a>, le ghiandole intestinali e le ghiandole bronchiali.<br> L'abbondanza e l'atipica densità del <a href="/fisiologia/muco.html">muco</a> prodotto rendono il fisiologico deflusso del secreto, dai dotti ghiandolari deputati, più complicato e meno efficiente; l'accumulo di muco dei dotti per l'escrezione comporta il verificarsi di fenomeni di <strong>ostruzione ghiandolare</strong>.<br> L'ostruzione ghiandolare che caratterizza la fibrosi cistica è responsabile di: sintomi intestinali e bronchiali, facilità alle infezioni, diminuzione della <a href="/salute/sterilita.html">fertilità</a> nelle donne, <a href="/salute/alitosi.html">alitosi</a>, cirrosi epatica, dolore ai <a href="/fisiologia/muscoli.html">muscoli</a>, <a href="/salute-benessere/nausea.html">nausea</a>, <a href="/salute/steatorrea.html" title="Steatorrea: cause, sintomi e cura delle Feci Grasse">steatorrea</a>, febbre, <a href="/salute-benessere/faringite.html" title="Faringite - Mal di Gola: sintomi, rimedi e quanto dura">faringite</a> ecc.<br> Causata da una mutazione genetica <strong>del gene CFTCR</strong>, la fibrosi cistica rientra nell'elenco delle fibrosi, perché, nel corso della malattia, sul pancreas si forma un insolito tessuto connettivo-fibroso.<br> Essendo una condizione genetica ereditaria, la fibrosi cistica è incurabile; tuttavia, oggi le persone che ne sono affette possono contare su diversi farmaci e sussidi terapeutici, capaci di alleviare la sintomatologia e ridurre il rischio di complicanze.</p> </section><a name="11"></a><section class="lst 11dv"><h2>Fibrosi retroperitoneale</h2> <p>La fibrosi retroperitoneale è la condizione patologica che si contraddistingue per la formazione di tessuto connettivo-fibroso, a livello del <strong>retroperitoneo</strong>. </p> <p>In anatomia umana, il retroperitoneo è il compartimento del corpo, situato dietro il <a href="/salute/peritonite.html">peritoneo</a>, che racchiude: i grossi <a href="/fisiologia/vasi-sanguigni.html">vasi</a> (es: <a href="/fisiologia/aorta.html">aorta</a> e <a href="/fisiologia/vena-cava.html">vena cava inferiore</a>), i <a href="/fisiologia/rene.html" title="Rene - Reni">reni</a>, le <a href="/fisiologia/surreni.html">ghiandole surrenali</a>, il pancreas, gran parte del <a href="/fisiologia/duodeno.html">duodeno</a>, il <a href="/anatomia/anatomia-fisiologia-colon.html">colon ascendente e discendente</a>, il <a href="/fisiologia/intestino-crasso.html">retto</a> e gli <a href="/salute-benessere/ureteri.html">ureteri</a>.<br> Sotto il profilo sintomatologico, la fibrosi retroperitoneale è tipicamente responsabile di: dolore alla parte inferiore della schiena, ipertensione, <a href="/salute-benessere/insufficienza-renale.html" title="Insufficienza Renale">insufficienza renale</a> e <a href="/bellezza/trombosi-venosa.html">trombosi venosa profonda</a>.<br> Il trattamento varia a seconda della gravità della condizione: nei casi meno gravi, è prevista una terapia farmacologica a base di <a href="/fisiologia/corticosteroidi-glucocorticoidi.html">glucocorticoidi</a>; nei casi più severi, invece, è quasi sempre necessaria una terapia chirurgica. </p> </section><a name="12"></a><section class="lst 12dv"><h2>Fibrosi Nefrogenica Sistemica</h2> <p>La fibrosi nefrogenica sistemica è una rara condizione morbosa, altamente debilitante, che risulta dalla contemporanea formazione di tessuto connettivo-fibroso sulla cute, sulle articolazioni, sugli occhi e sugli <a href="/salute-benessere/organi-interni.html" title="Organi Interni: Cosa e Quali sono? Suddivisione e Organi Vitali">organi interni</a>.<br> A causa del tessuto connettivo-fibroso presente, i suddetti organi e strutture del corpo sviluppano danni permanenti, che si ripercuotono a livello funzionale.<br> A rendere particolarmente interessante la fibrosi nefrogenica sistemica è il meccanismo d'insorgenza, in quanto è legato, con molta probabilità, all'uso di <strong><a href="/salute/mezzi-di-contrasto.html">mezzi di contrasto al gadolinio</a></strong> in pazienti con insufficienza renale grave (si veda <a href="/salute/risonanza-magnetica-contrasto.html">risonanza magnetica con contrasto</a>).<br> Le tipiche manifestazioni cliniche della fibrosi nefrogenica sistemica consistono in: presenza di cute dura, <a href="/prurito.html" title="Prurito: Cos’è? Cause, Diagnosi e Trattamento">prurito</a> e bruciore cutaneo diffuso, iperpigmentazione della pelle, ridotta <a href="/mobilita_articolare.htm">mobilità articolare</a>, scleromixedema, fascite <a href="/fisiologia/eosinofili.html" title="Eosinofili">eosinofila</a>, problemi cardiorespiratori e problemi di natura epatica.<br> Purtroppo, le numerose ricerche, finalizzate a trovare cure efficaci contro la fibrosi nefrogenica sistemica, non hanno portato a risultati soddisfacenti. Pertanto, i pazienti con fibrosi nefrogenica sistemica sono destinati a convivere con tale malattia.</p> <br> </section> </div>  <div id="relatedSearchesLeaf" class="sal-mBottom5x"></div> </div> <div class="sal-adv-slot sal-adv-slot-full sal-honcode sal-mBottom5x sal-adsense-slot"></div> <div class="sal-leaf-accessori sal-leaf-accessori-bottom sal-mBottom2x"> <div class="sal-leaf-accessori-sharebox"> <a href="mailto:?subject=Desidero%20condividere%20questo%20articolo%20con%20te&body=Leggi qui: Fibrosi - https://www.my-personaltrainer.it/salute/fibrosi.html" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareMAIL" data-action="email"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="/css/images/icons.svg#foglia-shareMAIL" /> </svg> </span> </a> <a href="javascript:void(window.open('http://www.facebook.com/sharer/sharer.php?u=https://www.my-personaltrainer.it/salute/fibrosi.html','MYP-shareFB','width=600,height=400'));" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareFB" data-action="facebook"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="/css/images/icons.svg#foglia-shareFB" /> </svg> </span> </a> <a href="javascript:void(window.open('https://twitter.com/intent/tweet?url=https://www.my-personaltrainer.it/salute/fibrosi.html&text=Fibrosi','MYP-shareTW','width=600,height=400'));" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareTW" data-action="twitter"> <span class="sal-icon"> <svg viewBox="0 0 28 28" style="padding: 5px;"> <use xlink:href="/css/images/icons.svg#foglia-shareTW" /> </svg> </span> </a> <a href="whatsapp://send?text=Leggi qui: Fibrosi - https://www.my-personaltrainer.it/salute/fibrosi.html" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareWA sal-hide-desktop" data-action="whatsapp"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="/css/images/icons.svg#foglia-shareWA" /> </svg> </span> </a> </div> </div> <section class="sal-outer sal-mBottom4x barlow"> <h4 class="sal-list-separator sal-list-heading barlow-cond sal-mBottom3x"><span class="sal-list-heading-content">Autore</span></h4> <div class="sal-author-container sal-mBottom4x"> <a href="/autore/antonio-griguolo.html" class="sal-author-pictorial sal-mBottom2x" title="Dott. 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Antonio Griguolo</a> </h4> </div> <span class="sal-author-bio">Laureato in Scienze Biomolecolari e Cellulari, ha conseguito un Master specialistico in Giornalismo e Comunicazione istituzionale della scienza. </span> </div> </section> <div class="sal-adv-slot sal-mBottom5x"><div class="sal-adv-outbrain"><div class="OUTBRAIN" data-src="https://www.my-personaltrainer.it/salute/fibrosi.html" data-widget-id="AR_2" data-ob-template="IT_my-personaltrainer.it"></div></div></div> </div> </article> </div> <aside class="sal-sidebar sal-column"> <div class="sal-elevator"> <div class="sal-adv-slot amePlaceholderBox sal-honcode sal-mBottom2x sal-hide-mobile"><div class="sal-adv-gpt" id="adv-gpt-box-container1"></div></div> <div class="sal-adv-slot sal-adv-slot-full"><div class="sal-adv-native" id="native-sidebar-1"></div></div> <div class="sal-adv-slot sal-adv-slot-full"><div class="sal-adv-native" id="native-sidebar-2"></div></div> <div class="sal-adv-slot sal-adv-slot-full"><div class="sal-adv-native" id="native-sidebar-3"></div></div> <div class="sal-adv-slot sal-hide-mobile"><div class="sal-adv-gpt" id="adv-gpt-promobox"></div></div> <div id="flyfirst-placement"></div> </div> </aside> <div class="sal-content"> <section class="sal-list sal-mBottom4x barlow" id="sal-related-DSA"> <h3 class="sal-list-separator sal-list-heading barlow-cond sal-mBottom2x"><span class="sal-list-heading-content">Articoli Correlati</span></h3> <article class="sal-list-item sal-mBottom5x"> <a href="https://www.my-personaltrainer.it/salute-benessere/sclerosi.html" class="sal-list-item-pictorial sal-related-article-link" data-pos="0" title="Sclerosi"> <picture> <img src="https://www.my-personaltrainer.it/salute-benessere/img2/sclerosi.jpg" height="250" width="210" alt="Sclerosi" loading="lazy" /> </picture> </a> <div class="sal-list-item-text barlow-cond"> <h3 class="sal-list-item-title"><a href="https://www.my-personaltrainer.it/salute-benessere/sclerosi.html#" title="Sclerosi" class="sal-related-article-link" data-pos="0">Sclerosi</a></h3> <p class="sal-list-item-summary sal-line-clamp sal-mBottom1x barlow"><a href="https://www.my-personaltrainer.it/salute-benessere/sclerosi.html" title="Sclerosi" class="sal-related-article-link" data-pos="0"> Cosa sono la sclerosi e la sclerosi massiva? 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This could be useful in cases // where you might want to aggregate related events: metric_inp_interaction_id: interactionId, non_interaction: true }; let now = new Date(); if(now.getHours() == 15 || now.getHours() == 16 || now.getHours() == 9 || now.getHours() == 22 || now.getHours() == 6 ) { // Send to Google Analytics gtag('event', 'INP_V1', eventParams); } } // Pass the reporting function to the web-vitals INP reporter: onINP(sendToGoogleAnalytics); </script> <script> var jsCounter = true; var sectionCounter = 0; var showInread = true; var isAdvertorial = false; var showAdsense = true; function MM_jumpMenu(targ,selObj,restore){ eval(targ+".location='"+selObj.options[selObj.selectedIndex].value+"'"); if (restore) selObj.selectedIndex=0; } mmLoader({ src: "/js/min/foglia.min.js?cb=feaadfac7280c50ba4c1d05f495a503d2b8e6250", async: true }); </script> <script> const outbrainDiv = document.querySelector(".sal-adv-outbrain"); if(outbrainDiv) { postTcfReady(startOutbrain = function() { loadJsbyIO('https://widgets.outbrain.com/outbrain.js','.sal-adv-outbrain','500px 0px') }); postConsentRejected(startOutbrainNoConsent = function() { loadJsbyIO('https://widgets.outbrain.com/outbrain.js','.sal-adv-outbrain','500px 0px') }); } </script> <script> // PERMUTIVE CONSENT CONFIG var permutiveEnabled = false; // GET CONSENT TOKEN (euconsent-v2) let token = (document.cookie.match(/(?:iub)?euconsent-v2=([^;]*)/) || [])[1]; const noadvurls = [ "https://www.my-personaltrainer.it/codici-sconto-efarma-marzo-2025.html" ] if (noadvurls.some(el => window.location.href.includes(el))) { document.body.classList.add("sal-adv-hidden") showPushDown = false } function setupPermutive() { __tcfapi('getTCData', 2, (tcData, success) => { if (success && tcData) { if(tcData.purpose.consents["1"] && tcData.purpose.consents["3"] && tcData.purpose.consents["5"] && tcData.purpose.consents["7"] && tcData.purpose.consents["9"] && tcData.vendor.consents["361"]) { permutiveEnabled = true; window._exaudiMediaset = window._exaudiMediaset || []; window._exaudiMediaset.push(["S",["_cm","PERMUTIVE"]]); } if(!token) { token = tcData.tcString; } } }); } postTcfReady(setupPermutive); let adMantxLoaded = false; function startAdvChain2022() { let startTime = performance.now(); const startAdmantx = function () { /* ADMANTX CONF */ let admantxOptions = `{"tag": "mypersonaltrainer.it","key": "4c1d28029914072d7b96a278ef7ef6fd25809a20638848ee8590da4a3cf07bc4","method": "descriptor","filter": "default","decorator": "template.mypersonal","type": "URL","mode": "async","body": "${escape(document.location.href)}"}`; let decodedAdmantx = 'https://euasync01.admantx.com/admantx/service?request='+admantxOptions; let urlAdmantx = encodeURI(decodedAdmantx); return mmLoader({ src: urlAdmantx, async: true },"advChain"); } const startNeodata = function () { /* NEODATA CONF */ let urlNeodata = `https://c.neodatagroup.com/mediaset.js`; if(permutiveEnabled) { return mmLoader({ src: urlNeodata, async: true },"advChain"); } return false; } const promises = [startAdmantx(),startNeodata()]; Promise.allSettled(promises). then((results) => { console.log('[startAdvChain2022] neodata e admantx elaborati', performance.now() - startTime); console.log('[startAdvChain2022]',results) //Permutive listen event adMantxLoaded = true; var adMantxReady = new Event("adMantxReady"); window.dispatchEvent(adMantxReady); console.log('[Permutive]' + adMantxLoaded); mmLoader({ src: "//adv.mediamond.it/hpsponsor/mypersonaltrainer/header_cls.v3.js", async: true },"advChain").then(()=> window.dispatchEvent(new Event("introCanStart"))); }).then(e => { console.log('[startAdvChain2022] mm caricato', performance.now() - startTime); const advChainEvent = new Event('advChainLoaded'); window.dispatchEvent(advChainEvent); }) } if (!noadvurls.some(el => window.location.href.includes(el))) { postTcfReady(startAdvChain2022) } function startPermutive() { console.log("[permutive] start permutive"); if(permutiveEnabled) { // SETUP CONSENT ON PERMUTIVE permutive.consent({ "opt_in": true, "token": token }); console.log(`[permutive] setup consent with token`, token); // SETUP PERMUTIVE USER IDENTITIES let identities = [ {"id": getGaClientId(), "tag": "ame_publisher_id", "priority": 1} // AME PUBLISHER ID ]; permutive.identify(identities); console.log(`[permutive] setup user identities`, identities); // ADDON PERMUTIVE adMantxLoaded ? addonPermutive() : window.addEventListener('adMantxReady', () => addonPermutive()); } } function postPermutiveIdGeneratorReady() { if(typeof permutiveIdGeneratorReady !== 'undefined') { startPermutive(); } else { window.addEventListener('permutiveIdGeneratorReady', function () { startPermutive(); }); } } function addonPermutive() { let label = !(ADX_label.includes(ADX_lemmas)) ? `${ADX_label},${ADX_lemmas},${ADX_people},${ADX_categories},${ADX_places},${ADX_companies}` : ADX_label; let semantic_label = label.split(','); console.log('[Permutive label]' + semantic_label); const hour = new Date().getHours(); let time_of_day = (hour < 12 ? 'Morning' : hour < 17 ? 'Afternoon' : hour < 22 ? 'Evening' : 'Night'); const d = new Date(); const weekday = ["Domenica","Lunedì","Martedì","Mercoledì","Giovedì","Venerdì","Sabato"]; let day_of_week = weekday[d.getDay()]; let platform = document.documentElement.clientWidth < 480 ? 'mypersonaltrainer-web-mobile' : 'mypersonaltrainer-web-desktop'; /*Tutte le condizioni utili al popolamento dell'oggetto addonData sono contenute nel file pageDetailsDetect*/ let addonData = { "page":{ semantic_label, // ["list", "of", "strings"] "brand": "My Personal Trainer", // "text" time_of_day, // "text" "page": { "section": "salute", "type": "Foglia" // "text" }, "publisher": "Mondadori", // "text" day_of_week, "published_at": "2020-03-12T15:24:28+01:00", "meta_keywords":["Salute","Fibrosi"], "article": { "authors": "Dott. Antonio Griguolo", // "text" "title": "Fibrosi" // "text" }, platform, "site_name": "mypersonaltrainer", // "text" "classifications_watson": { "categories": "$alchemy_taxonomy", "keywords": "$alchemy_keywords" } } } permutive.addon('web', addonData); console.log(`[permutive] addon web`, addonData); } postTcfReady(postPermutiveIdGeneratorReady); function injectAudioSentinel() { return new Promise((resolve, reject)=>{ const videoSentinel = window.top.document.createElement('video'); videoSentinel.src = "/video-sentinel/sentinel.mp4" videoSentinel.controls = true; videoSentinel.muted = false; videoSentinel.playsInline = true; videoSentinel.volume = 0.001; videoSentinel.setAttribute("style", "position:fixed;bottom:-200px;z-index:-1;"); window.top.document.body.appendChild(videoSentinel); console.log('[Check AudioOn] Video sentinella caricato'); resolve(checkSentinelResponse(videoSentinel)); }); } function checkSentinelResponse(elem){ return new Promise((resolve, reject) => { let interrogateSentinel = elem.play(); if (interrogateSentinel !== undefined){ interrogateSentinel.then(function () { resolve(audioModeOnSentinel = true); console.log('[Check AudioOn] AudioOn permesso!', 'Valore audioModeOnSentinel:',audioModeOnSentinel); }).catch(function (error) { resolve(); // Non modifico audioModeOnSentinel. È false di default console.log('[Check AudioOn]', error) }) } }) } function setCookie(cname, cvalue, exhours, domain='') { // IMPORTANTE - inserire il dato "exhours" in ore indica la scadenza del cookie const d = new Date(); d.setTime(d.getTime() + (exhours * 3600000)); let expires = "expires="+ d.toUTCString(); document.cookie = cname + "=" + cvalue + ";" + expires + ";domain="+domain + ";path=/"; } function getCookie(cname) { let name = cname + "="; let decodedCookie = decodeURIComponent(document.cookie); let ca = decodedCookie.split(';'); for(let i = 0; i <ca.length; i++) { let c = ca[i]; while (c.charAt(0) === ' ') { c = c.substring(1); } if (c.indexOf(name) === 0) { return c.substring(name.length, c.length); } } return ""; } /*Tutte le condizioni utili al popolamento dell'oggetto addonData sono contenute nel file pageDetailsDetect*/  /* Setta una variabile per inibire la pushdown su HP, hp di categorie e in presenza di altri video */ let showPushDown = true; let audioModeOnSentinel = false; let checkUserConnection = true; if(navigator.connection !== undefined && navigator.connection.downlink < 2) { showPushDown = false; checkUserConnection = false; console.log('[Push-diretta] Push inibita per connessione troppo lenta, downlink a',navigator.connection.downlink); } //Il parametro "website" è differente per desk, mob. android, mob. ios let website = 'mppv'; if (/(iPad|iPhone|iPod)/g.test(navigator.userAgent)) { website = "mppm-ios"; } else if (navigator.userAgent.toLowerCase().indexOf("android") !== -1){ website = "mppm-android"; } let isMobile = window.innerWidth < 1000; //Il parametro "webpushdownTargetElement" indica all'interno di quale ID erogare la push e/o dove riposizionarla (desk/mob) in caso di chiusura let targetElementId = 'flyfirst-mobile-placement'; if(!isMobile) targetElementId = 'flyfirst-placement'; let pushFrequencyCap = { mobile: 24, //Impostare il valore in ORE desktop: null, //Impostare null se non utilizzato } let checkCap = isMobile ? getCookie('pushDownCapMobile') : getCookie('pushDownCapDesktop'); console.log(`%c[Push-diretta] Il valore di pushFrequencyCap ${isMobile ? 'Mobile' : 'Desktop'} risulta settato a: ${isMobile ? pushFrequencyCap.mobile : pushFrequencyCap.desktop }`,'background-color: #55FFFF;padding:5px;color:black;'); function initPushdown() { //Le variabili, website, targetElementId, showPushDown e mobile sono inizializzate in pushdown-common-var.inc.tpl //PushConfObj è l'oggetto che contiene tutti i parametri con i quali andremo a inizializzare la PUSH const pushConfObj = { adServer:"freewheel", amazonTam: { enabled:true, pubID:'5123', sellerData:{ asi:'adkaora.com', sid:'1111', hp:1 } }, advFallbacks:true, closeFlyingAfter:7000, flyMode:"fade", targetElementId, audioModeOn: audioModeOnSentinel,////////////////////SUI VIDEO DI CONTENUTO L'iniziolizzazione passa da PAMELA:PHP C controlla li.... type:"flyfirst", website, eventListener: (ptpEvent) => { if (ptpEvent === 'preroll_started'){ if (isMobile && typeof pushFrequencyCap.mobile == "number" && (typeof checkCap == null || checkCap === '')) { console.log("%c[Push-diretta] Il preroll è stato erogato setto il cookie pushDownCapMobile.", 'background-color: #FFFF55;padding:5px;color:black;'); setCookie('pushDownCapMobile','enabled', pushFrequencyCap.mobile); } if (!isMobile && typeof pushFrequencyCap.desktop == "number" && (typeof checkCap == null || checkCap === '')) { console.log("%c[Push-diretta] Il preroll è stato erogato setto il cookie pushDownCapDesktop.", 'background-color: #FFFF55;padding:5px;color:black;'); setCookie('pushDownCapDesktop','enabled', pushFrequencyCap.desktop); } } } }; //Facciamo partire la chiamata a PTP per il caricamento di tutte le risorse del player (function (a,l,t,e,r) { a[e] = a[e] || function(s) { (a[e].run = a[e].run || []).push(s)}; let g,z = l.getElementsByTagName(t)[0]; if (l.getElementById(e)){return;} g = l.createElement(t); g.id = e; g.src = r; g.async = 1; z.parentNode.insertBefore(g,z); }(window, document, 'script', 'AVPushLoader', "https://ptp.stbm.it/pushdown/loader/av/pushdown-loader.js")); console.log("[Push-diretta] Parametri di Configurazione:", pushConfObj); //Avviamo la Pushdown! AVPushLoader(pushConfObj); console.log("%c[Push-diretta] Push inizializzata.", 'background-color: #55FF55;padding:5px;color:black;'); } /***************************************** FINE configurazioni push*/ /* * injectAudioSentinel crea un video fuori dalla viewport. * Prova a farlo partire con audio bassissimo. * Se si ottiene una promise l'audio on è consentito e la VAR "audioModeOnSentinel" viene impostata a true. * Se la variabile audioModeOnSentinel è true usiamo le api del player per impostare un volume al preroll. * Se la variabile audioModeOnSentinel è true PTP passa nella chiamata le nuove tag che ci ha fornito mediamond. */ function pushChainStarter(){ let audioFrequencyCap = 12; let audioCheckCap = getCookie('audioCap'); injectAudioSentinel().then(function () { if (showPushDown && !inSpecial &&(typeof checkCap == null || checkCap === '') && checkUserConnection === true) { const startPushDelay = () => { setTimeout(()=>{ initPushdown(); console.log(`%c[Push-diretta] Controllo showPushDown: ${showPushDown}. Controllo inSpecial: ${inSpecial}. | siamo su ${isMobile ? 'Mobile' : 'Desktop'} e il cookie pushFrequencyCap NON è ancora stato salvato nel browser. Controllo connessione: ${checkUserConnection}. Possiamo erogare!`, 'background-color: #55FF55;padding:5px;color:black;'); },15000) } if (!noadvurls.some(el => window.location.href.includes(el))) { postTcfReady(startPushDelay); } } else { console.log(`%c[Push-diretta] Controllo showPushDown: ${showPushDown}. Controllo inSpecial: ${inSpecial}. Valore cookie: ${checkCap || 'Disabled'}. Controllo connessione: ${checkUserConnection}. Non possiamo erogare!`,'background-color: #FF5555;padding:5px;color:black;'); } }).then(function () { if (audioModeOnSentinel){ window.addEventListener("preroll_started", function() { console.log('[Check AudioOn] preroll_started'); setTimeout(function () { if (!isMobile && AVPushRunningInstances[0].opt.mode !== 'content' && (typeof audioCheckCap == null || audioCheckCap === '')){ AVPushRunningInstances[0].api.setVolume(0.05); ///////////////////////////Solo per le pushdown desktop impostiamo un CAP per l'audio_on di 12 ore setCookie('audioCap','enabled', audioFrequencyCap); console.log('[Check AudioOn] Setto il cap audio'); } else if (!isMobile && AVPushRunningInstances[0].opt.mode !== 'content' && audioCheckCap === 'enabled'){ console.log('[Check AudioOn] Cap audio rilevato non imposto audio'); } else { AVPushRunningInstances[0].api.setVolume(0.05); console.log('[Check AudioOn] Siamo su mobile o è in esecuzione un video content. Imposto audio on'); } },200) }); } }) } postTcfReady(pushChainStarter); //Label video del giorno stuckAVPush = (id) => { window.addEventListener('pushClose', ev => { window.removeEventListener('pushClose', stuckAVPush); if (!document.querySelector('.sal-video-giorno')){ let flyfirstPlacement = document.getElementById(id); flyfirstPlacement.insertAdjacentHTML('beforebegin', `<div class="sal-video-giorno">Video del giorno</div>`); } }); } window.innerWidth >= 1000 ? stuckAVPush('flyfirst-placement') : stuckAVPush('flyfirst-mobile-placement'); (function () { /***************************************** Gestiamo internamente la chiamata alla intro*/ let introFrequencyCap = !inSpecial ? 6 : null; console.log(`%c[Load Intro] introFrequencyCap : ${introFrequencyCap}.`,'background-color: #55FF55;padding:5px;color:black;'); let checkCap = getCookie('introCap'); function startIntro(){ window.googletag = window.googletag || {}; googletag.cmd = googletag.cmd || []; googletag.cmd.push(function() { if (typeof checkCap == null || checkCap === '' || inSpecial){ console.log(`%c[Load Intro] Cookie non settato procedo con la intro.`,'background-color: #55FF55;padding:5px;color:black;'); if (typeof initIntro === "function"){ console.log(`%c[Load Intro] Intro Chiamata.`,'background-color: #55FF55;padding:5px;color:black;'); initIntro(); } else{ console.log(`%c[Load Intro] La funzione initIntro non risulta dichiarata. Probabile race contidion con file mediamond.`,'background-color: #FF5555;padding:5px;color:black;'); } googletag.pubads().addEventListener('slotRenderEnded', function (event) { let slotId = event.slot.getSlotElementId(); // La size della intro [1,1] if ((slotId === 'adv-gpt-outofpage' && !event.isEmpty) && (event.size[0] === 1 && event.size[1] === 1) && typeof introFrequencyCap === "number"){ setCookie('introCap','enabled', introFrequencyCap, ".my-personaltrainer.it"); console.log(`%c[Load Intro] Intro erogata. Setto il cookie.`,'background-color: #FFFF55;padding:5px;color:black;'); } }); } else { console.log(`%c[Load Intro] Il cookie introCap risulta settato. Non possiamo erogare la intro.`,'background-color: #FF5555;padding:5px;color:black;'); } }); } window.addEventListener('introCanStart', function () { if (!noadvurls.some(el => window.location.href.includes(el))) { postTcfReady(startIntro) } }); })();/***************************************** FINE configurazioni intro*/ (function(){ let iframeVideo = document.querySelector('.sal-container-video-nova'); if(iframeVideo != null) { console.log('[pushNoConsent] bloccata per presenza video in pagina'); return false; } let trackAnalytics = false; function startPushNoConsent() { window.initStartPushNoConsent = 1; console.log('[pushNoConsent] track init'); if (typeof gtag === "function" && trackAnalytics == true) { gtag("event", 'pushNoConsentV1', { event_category: 'pushNoConsentV1', event_action: 'init', event_label: document.location.href, non_interaction: true }); } var GlobalPusTimerStart = new Date().getTime(); console.log('[push] Pamela pushdown diretta initPushFlyfirst fopv flyfirst '); var ptpAdserver = 'freewheel'; let obj = { website, type: "flyfirst", flyMode: "fade", closeFlyingAfter: 7000, adServer: ptpAdserver, targetElementId, eventListener: (eventName, eventData) => { const eventBlocking = [ "adblocker_detected", "preroll_not_served", "autoplay_denied", "triggered_fallback", "preroll_error" ]; if(eventName === 'preroll_started'){ console.log('[pushNoConsent]', 'track preroll started'); if (typeof gtag === "function" && trackAnalytics == true) { gtag("event", 'pushNoConsentV1', { event_category: 'pushNoConsentV1', event_action: 'preroll_started', event_label: document.location.href, non_interaction: true }); } } // [ NPA ] event listeners per interstital ADK (adv fill se non c'è preroll) // if (eventBlocking.includes(eventName)) { // if (typeof AdKaora.loadInterstitial === 'function' && !adkPageSlots.displayed.adk_interstitial) { // console.debug('[ NPA ] init interstitial ADK causa preroll non erogato'); // AdKaora.loadInterstitial("adk_death-div"); // } // } } }; (function (a, l, t, e, r) { a[e] = a[e] || function (s) { (a[e].run = a[e].run || []).push(s) }; let g, z = l.getElementsByTagName(t)[0]; if (l.getElementById(e)) { return; } g = l.createElement(t); g.id = e; g.src = r; g.async = 1; z.parentNode.insertBefore(g, z); }(window, document, 'script', 'AVPushLoader', "https://ptp.stbm.it/pushdown/loader/av/pushdown-loader.js")); console.log('[pushNoConsent]', obj); AVPushLoader(obj); } // interstitial NPA se preroll non presente // let startInterstitialNoConsent = () => { // // [ NPA ] event listeners per interstital ADK (adv fill se non c'è preroll) // const eventBlocking = [ // "adblocker_detected", // "preroll_not_served", // "autoplay_denied", // "triggered_fallback", // "preroll_error" // ]; // eventBlocking.forEach(function(e) { // window.addEventListener(e, function() { // if (typeof AdKaora.loadInterstitial === 'function' && !adkPageSlots.displayed.adk_interstitial) { // console.debug('[ NPA ] init interstitial ADK causa preroll non erogato'); // AdKaora.loadInterstitial("adk_death-div"); // } // }); // }) // } const ADVNoConsentFlow = () => { // let NPAtarget = window.innerWidth < 1000 ? 'adv-gpt-box-mobile-container1' : 'adv-gpt-box-container1'; // if (document.getElementById(NPAtarget)){ // document.getElementById(NPAtarget).parentNode.setAttribute('id','box300NPA'); // } setTimeout(function() { mmLoader({ src: "https://cdn.adkaora.space/mondadori/generic/prod/adk-init.js", async: true, // type: 'module' }, "ADVNoConsentFlow") // .then(element => { // document.addEventListener("PWTBidComplete", function(e) { // console.debug('PWTBid completed.') // // check slot vuoti: // let emptyNPASlots = {}; // if(ifrmAdvMh.offsetHeight === 0){ // Object.assign(emptyNPASlots, { 'masthead': divslotnameStrip }); // } else { // AmeMh.strip_animation(); // } // if(ifrmAdvBox.offsetHeight === 0){ // Object.assign(emptyNPASlots, { 'box300': divslotnameBox }); // } // document.dispatchEvent(new CustomEvent("EmptyNPASlot", { // detail: emptyNPASlots // })); // }); // }, "ADVNoConsentFlow") // .then( element => mmLoader({ // src: "https://adv.mediamond.it/librerie/js-no-consent/ame/adv_no_consent.js", // async: true // }, "ADVNoConsentFlow")) .then(element => { setTimeout(function() {startPushNoConsent() },15000); // startInterstitialNoConsent(); }, "ADVNoConsentFlow"); },500); } if (!noadvurls.some(el => window.location.href.includes(el))) { postConsentRejected(ADVNoConsentFlow) } // debug only: // document.addEventListener("EmptyNPASlot", function(e) { // console.debug('[NPA] EmptyNPASlot event:', e.detail); // }); })(); let adsensePush = () => { let adsense_slots = document.querySelectorAll(".adsbygoogle"); if(adsense_slots.length > 0) { for (var i = 0; i < adsense_slots.length; i++) { (adsbygoogle = window.adsbygoogle || []).push({}); } } } function startAdsense() { setTimeout(() => { mmLoader({ src: "https://pagead2.googlesyndication.com/pagead/js/adsbygoogle.js", async: true },"adsenseChain").then(element => { adsensePush(); initAdsenseDone = true; }); },3000) } if (!noadvurls.some(el => window.location.href.includes(el))) { postTcfReady(startAdsense) } </script>  <script async src="https://dafne.sirio.stbm.it/utility-fe/prod/general/network.common.v3.js" importance="high"></script>  <script> const push_notification_api_data = { 'ajax_url': 'https://np.altervista.org/', 'account': 'myp-website', 'platform': 'myp-website' }; </script> <script type="text/javascript"> setTimeout(function() { mmLoader({ src: "https://www.gstatic.com/firebasejs/10.9.0/firebase-app-compat.js", async: true }, "pushNotificationChain") .then(element => mmLoader({ src: "https://www.gstatic.com/firebasejs/10.9.0/firebase-messaging-compat.js", async: true }, "pushNotificationChain")) .then(element => mmLoader({ src: "/js/firebase-messaging.js?cb=feaadfac7280c50ba4c1d05f495a503d2b8e6250", async: true }, "pushNotificationChain")) }, 5000); </script> <script> document.addEventListener("DOMContentLoaded", () => { let is_mobi = /Mobi|Android/i.test(navigator.userAgent); let is_paid = /utm_source=campLBSSAB/.test(location.search); document.querySelectorAll("a").forEach(a => { if (a.href.search('tag=pluginmyp-21') === -1) return; let link = a.href; if (link.search('ascsubtag') == -1) { link += "&ascsubtag="+(document.body.dataset.id||'unknown')+"-widget-"+(is_mobi ? "mobile" : "desktop"); } else if (is_mobi) { link = a.href.replace(/(ascsubtag=\w+-\w+)-desktop/, "$1-mobile"); } if (is_paid) link += "-paid"; a.href = link; }); }); </script> <script> var mapp_conf_data = { "page_type": "Article", "section": "salute", "subsection": "", "tags": { supertag:"salute,fibrosi", extratag:"" }, }; </script>  <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-T6W4WMK8');</script> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-T6W4WMK8" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <script> window.addEventListener("DOMContentLoaded", () => { if (/Mobi|Android/i.test(navigator.userAgent)) Array.from(document.querySelectorAll('a[href^="https://www.amazon.it/dp/"]')).forEach(a => a.href = a.href.replace(/-desktop-/, "-mobile-")); }); </script> </body> </html>