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id="gsc_vcpb" data-edit-link="/citations?view_op=edit_citation&hl=en&user=hETQx7cAAAAJ&sortby=title&citation_for_view=hETQx7cAAAAJ:L1USKYWJimsC&citation_for_view=hETQx7cAAAAJ:L1USKYWJimsC&back_view_op=view_citation"><form method="post" id="gsc_vcpb_btns" action="/citations?view_op=view_citation&hl=en"><input type="hidden" name="xsrf" value="ADIE8skAAAAAZ0N82mmgwPjlkXTHkgJIIwfEc1s"><input type="hidden" name="s" value="hETQx7cAAAAJ:L1USKYWJimsC"><input type="hidden" name="continue" value="/citations?view_op=list_works&hl=en&hl=en&user=hETQx7cAAAAJ&sortby=title"></form><div id="gsc_oci_title_wrapper"><div id="gsc_oci_title"><a class="gsc_oci_title_link" href="https://books.google.com/books?hl=en&lr=&id=4Ds8C0yTMzoC&oi=fnd&pg=PA475&dq=info:WLc9JFPSGHUJ:scholar.google.com&ots=xrPyfrbD2b&sig=EfmQTP5zOE7MnCzR3K_ZOmBjRH4" data-clk="hl=en&sa=T&ei=WitCZ8cKqb7L1g_v_MWIAQ">43 Applications of Proteomics to Metastasis Diagnosis and Individualized Therapy</a></div></div><div id="gsc_oci_table"><div class="gs_scl"><div class="gsc_oci_field">Authors</div><div class="gsc_oci_value">Mariaelena Pierobon, Alessandra Luchini, Alessandra Silvestri, Virginia Espina, Emanuel F Petricoin, Lance A Liotta</div></div><div class="gs_scl"><div class="gsc_oci_field">Publication date</div><div class="gsc_oci_value">2011/4/25</div></div><div class="gs_scl"><div class="gsc_oci_field">Journal</div><div class="gsc_oci_value">Cancer Metastasis: Biologic Basis and Therapeutics</div></div><div class="gs_scl"><div class="gsc_oci_field">Pages</div><div class="gsc_oci_value">475</div></div><div class="gs_scl"><div class="gsc_oci_field">Publisher</div><div class="gsc_oci_value">Cambridge University Press</div></div><div class="gs_scl"><div class="gsc_oci_field">Description</div><div class="gsc_oci_value" id="gsc_oci_descr"><div class="gsh_small"><div class="gsh_csp">Cancer is too often diagnosed and treated too late, when the tumor cells have already invaded and metastasized. At this stage, therapeutic modalities are limited in their success. Detecting cancers at their earliest stages, even in the premalignant state, means that current or future treatment modalities might have a higher likelihood of a true cure. For example, ovarian cancer is usually treated at an advanced stage. The resulting five-year survival rate is 35 percent to 40 percent for patients with late-stage disease who receive the best possible surgical and chemotherapeutic intervention. In contrast, if ovarian cancer is detected at an early stage, conventional therapy produces a high rate of five-year survival (95%)[1]. Thus, early detection, by itself, could have a profound effect on the successful treatment of this disease. A clinically useful biomarker for early cancer detection should be measurable in a readily accessible body fluid, such as serum [2], urine [3], or saliva [4]. Clinical proteomic methods are especially well suited to discovering such biomarkers [5]. Serum or plasma has been the preferred medium for discovery, because this fluid is a protein-rich information reservoir that contains the traces of what has been encountered by the blood during its constant perfusion and percolation throughout the tissues [6].</div><div class="gsh_csp">Despite decades of effort in the face of this urgent clinical need, single biomarkers have not been found that can reach an acceptable level of specificity and sensitivity required for routine clinical use for the early stage detection of the most common cancers. Most investigators believe that this is because of both the</div></div></div></div><div class="gs_scl"><div class="gsc_oci_field">Scholar articles</div><div class="gsc_oci_value"><div class="gsc_oci_merged_snippet"><div><a href="/scholar?oi=bibs&cluster=8437725156410767192&btnI=1&hl=en">43 Applications of Proteomics to Metastasis Diagnosis and Individualized Therapy</a></div><div>M Pierobon, A Luchini, A Silvestri, V Espina… - Cancer Metastasis: Biologic Basis and Therapeutics, 2011</div><div><a class="gsc_oms_link" href="https://scholar.google.co.in/scholar?oi=bibs&hl=en&q=related:WLc9JFPSGHUJ:scholar.google.com/">Related articles</a> <a class="gsc_oms_link" href="https://scholar.google.co.in/scholar?oi=bibs&hl=en&cluster=8437725156410767192">All 2 versions</a> </div></div></div></div></div></div></div></div><div id="gs_ftr_sp" role="presentation"></div><div id="gs_ftr" class="gs_md_rmb" role="contentinfo"><div id="gs_ftr_rt"><a href="//www.google.co.in/intl/en/policies/privacy/">Privacy</a><a href="//www.google.co.in/intl/en/policies/terms/">Terms</a><a href="javascript:void(0)" ontouchstart="gs_evt_dsp(event)" role="button" aria-controls="gs_ftr_mnu" aria-haspopup="true" class="gs_press gs_md_tb">Help</a></div><div id="gs_ftr_mnu" class="gs_md_d gs_md_ds gs_ttzi gs_md_ulr" role="menu" tabindex="-1"><a role="menuitem" href="/intl/en/scholar/about.html" tabindex="-1" class="gs_md_li">About Scholar</a><a role="menuitem" href="//support.google.com/websearch?p=scholar_dsa&hl=en" tabindex="-1" class="gs_md_li">Search help</a></div></div></div></body></html>