Biometric Research Program (BRP)

<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "https://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html xmlns="https://www.w3.org/1999/xhtml"> <head> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1" /> <title>Biometric Research Program (BRP)</title>  <style type="text/css"> @import url(/includefiles/redesign/css/desktop/interior.css) (min-width: 1037px); @import url(/includefiles/redesign/css/tablet/interior.css) (min-width: 680px) and (max-width: 1036px); @import url(/includefiles/redesign/css/phone/interior.css) (min-width: 451px) and (max-width: 679px); @import url(/includefiles/redesign/css/xs/interior.css) (max-width: 450px); </style> <script type="text/javascript" src="/includefiles/redesign/javascript/jquery-3.7.0.min.js"></script> <script type="text/javascript" src="/includefiles/redesign/javascript/jquery-ui.js"></script> <script type="text/javascript" src="/includefiles/redesign/javascript/jquery-ui-tabs-rotate.js"></script> <script type="text/javascript" src="/includefiles/redesign/javascript/jquery.rwdImageMaps.js"></script> <script type="text/javascript" src="/includefiles/redesign/javascript/superfish.js"></script> <script type="text/javascript" src="/includefiles/redesign/javascript/globalfunctions.js"></script> <script type="text/javascript" src="/includefiles/redesign/javascript/SpryAccordion.js"></script> <script type="text/javascript" src="/includefiles/redesign/javascript/lastupdate.js"></script> <meta name="viewport" content="width=device-width, initial-scale=1" /> <script language="JavaScript" type="text/javascript" src="https://static.cancer.gov/webanalytics/WA_DCTD_PageLoad.js"></script> </head> <body> <div class="skipToContent"><a title="Skip to Content" href="#mainColumn">Skip to Content</a></div> <div id="pageWrapper"> <div id="contentWrapper">  <div id="toplevelNAV" class="clearfix"> <div id="DCTDlogo"><img src="/images/redesign/dctd_logo_54.png" alt="NIH, National Cancer Institute, Division of Cancer Treatment and Diagnosis (DCTD)" border="0" id="NIHbanner" usemap="#NIHmap" /> <map name="NIHmap"> <area shape="rect" coords="2,20,89,80" href="https://www.nih.gov" target="_blank" alt="NIH - National Institutes of Health" /> <area shape="rect" coords="99,29,351,45" href="https://www.cancer.gov" target="_blank" alt="National Cancer Institute" /> <area shape="rect" coords="99,52,597,78" href="https://dctd.cancer.gov" target="_blank" alt="DCTD - Division of Cancer Treatment and Diagnosis" /> </map> </div> </div>  <div style="width: 100%; background-color: #1c5e86;"> <div id="ribbonText"><a href="/"><img src="/includefiles/redesign/images/brp-logo2.png" alt="Biometric Research Program" /></a></div> </div> <p> </p>  <div id="mainContent">  <div id="mobileMenu"> <div id="menuToggle" class="mobileButtons"><a id="menuButton" href="#"><img src="/images/redesign/mb_menu.png" alt="Menu" /></a></div> <div id="contactButton" class="mobileButtons"><a href="contacts.htm"><img src="/images/redesign/mb_contact.png" alt="Contact BRP" /></a></div> <div id="hideSearch"><a id="hideSearchButton" class="searchToggle" href="#"><img src="/images/redesign/mb_hideSearch.png" alt="Show menu" /></a></div> <div id="toplevelLINKS"> <div id="toplevelTextLinks"><a href="/">Home</a> | <a href="/sitemap.htm">Sitemap</a> | <a href="/contacts.htm">Contact BRP</a></div> <div id="searchBox"> <script type="text/javascript" src="/includefiles/redesign/javascript/search.js"></script> <form action="https://dctd.cancer.gov/search/search.asp" method="get" enctype="application/x-www-form-urlencoded" name="SearchForm" id="SearchForm" onSubmit="validate_search()"> <label id="searchLabel" for="zoom_query">Search this site</label> <input type="text" name="zoom_query" id="zoom_query" maxlength="255" class="search" value="Search this site" /> <input class="searchButton" id="mobileSearchButton" type="image" src="/images/redesign/mb_search.png" name="Action" alt="Search" /> </form> </div> </div> <div id="showSearch"><a id="showSearchButton" class="searchToggle" href="#"><img src="/images/redesign/mb_search.png" alt="Search this site" /></a></div> </div>  <div id="dropDownMenu"> <ul class="sf-menu"> <li id="homeLink"><a href="/default.htm">Home</a></li> <li><a href="/aboutBRP/default.htm">About BRP</a> <ul> <li><a href="/aboutBRP/Staff.htm">Staff Directory</a></li> <li><a href="/aboutBRP/bb.htm">Biostatistics Branch</a></li> <li><a href="/aboutBRP/csb.htm">Computational & Systems Biology Branch</a></li> <li><a href="/aboutBRP/alumni.htm">BRP Alumni</a></li> <li><a href="/aboutBRP/position.htm">Position Available</a></li> </ul> </li> <li><a href="/researcharea/default.htm">Research Area</a> <ul> <li><a href="/researcharea/clinicaltrials.htm">Clinical Trials</a></li> <li><a href="/researcharea/drugdiscovery.htm">Drug Discovery and Pre-Clinical Development</a></li> <li><a href="/researcharea/molecularcancerdiag.htm">Molecular Cancer Diagnosis</a></li> <li><a href="/researcharea/biomedimag.htm">Biomedical Imaging</a></li> <li><a href="/researcharea/csb.htm">Computational and Systems Biology</a></li> <li><a href="/researcharea/biostat.htm">Biostatistical Research</a></li> </ul> </li> <li><a href="/brb/samplesize/default.htm">Online Sample Size Calculation</a> <ul> <li><a href="/brb/samplesize/index1.html">Predictive Biomarkers in Phase II/III Clinical Trials</a></li> <li><a href="/brb/samplesize/otsd.html">Optimal Two-Stage Designs for Phase II Clinical Trials</a></li> <li><a href="/brb/samplesize/ip23study1.html">Integrated Phase II/III Study</a></li> <li><a href="/brb/samplesize/samplesize4GE.html">Sample Size Planning for Developing Classifiers</a></li> <li><a href="/shinyapps-main.html">Design, Monitoring and Analysis of Bayesian Basket Discovery Trials</a></li> <li><a href="/shinyapps-main.html">Bayesian Phase II Single Arm Clinical Trials</a></li> </ul> </li> <li><a href="/programdownload/default.htm">Software Download</a> <ul> <li><a href="/programdownload/Methodologic.htm">Accelerated Titration Design Software</a></li> <li><a href="/BRB-ArrayTools/">BRB-ArrayTools</a></li> <li><a href="/seqtools/">BRB-SeqTools</a></li> <li><a href="/TPWshiny/">TPWshiny</a></li> <li><a href="/d3oncoprint/">D3Oncoprint</a></li> <li><a href="/OpenGeneMed/">OpenGeneMed</a></li> <li><a href="/programdownload/Opt.htm">Optimal Two-Stage Phase II Design Software</a> </li> <li><a href="/programdownload/pCRsoftware.html">pCR Trial-Level Surrogate Analysis Software</a></li> <li><a href="/splicing/">MutSpliceDB</a></li> <li><a href="/tmbLab/">tmbLab</a></li> </ul> </li> <li><a href="/reportsPublications/default.htm">Publications and Reports</a> <ul> <li><a href="/reportsPublications/reprints.htm">Reprints</a></li> <li><a href="/reportsPublications/presentations.htm">Workshop Presentations</a></li> </ul> </li> </ul> </div>  <div id="bodycopy" class="two c01">  <div id="columnA"> <div id="sectionLinks"> <div><a href="/programdownload/Methodologic.htm" class="c02">Accelerated Titration Design Software</a> </div> <div><a href="/BRB-ArrayTools/" class="c02">BRB-ArrayTools</a></div> <div><a href="/seqtools/" class="c02">BRB-SeqTools</a></div> <div><a href="/d3oncoprint/" class="c02">D3Oncoprint</a></div> <div><a href="/TPWshiny/" class="c02">TPWshiny</a></div> <div><a href="/OpenGeneMed/" class="c02">OpenGeneMed</a></div> <div><a href="/programdownload/Opt.htm" class="c02">Optimal Two-Stage Phase II Design Software</a></div> <div><a href="/programdownload/pCRsoftware.html" class="c02">pCR Trial-Level Surrogate Analysis Software</a> </div> <div><a href="/splicing/" class="c02">MutSpliceDB</a></div> <div><a href="/tmbLab/" class="c01">tmbLab</a></div> </div> </div>  <div id="mainColumn" class="clearfix"> <div class="mainContentWrapper"> <div id="pageSectionLinks"><a href="/programdownload/default.htm">Software download</a></div> <div id="lastupdated">Last Updated: <script>lastUpdate();</script> </div> <h2>FOCR/NCI TMB Calibration Tool: tmbLab</h2> <p><strong>Lisa McShane, Laura Yee, and Qian Xie</strong></p> <p>This package generates and applies a calibration model as described in Phase 2 of the Friends of Cancer Research (FOCR) tumor mutational burden (TMB) harmonization project. The software estimates a calibration curve with corresponding prediction limits to quantify the average relationship between WES and panel TMB assay values as well as variability around that curve. Intervals of uncertainty are also provided to accompany the corresponding WES-calibrated TMB values.</p> <iframe src="/tmbLab/index1.html" height="1050px" width="100%" title="tmbLab"></iframe> </div> </div>  <div id="columnB"> </div> </div> </div> </div> <div id="footer"> <ul> <li><a href="/default.htm">BRP Home</a></li> <li><a href="/contacts.htm">Contact BRP</a></li> <li><a href="/sitemap.htm">Site Map</a></li> <li><a href="https://www.cancer.gov/policies/accessibility" target="_blank">Accessibility</a></li> <li><a href="https://www.cancer.gov/policies/disclaimer" target="_blank">Disclaimer Policy</a></li> <li><a href="https://www.cancer.gov/policies/foia" target="_blank">FOIA</a></li> <li class="last"><a href="https://www.hhs.gov/vulnerability-disclosure-policy" target="_blank">HHS Vulnerability Disclosure</a></li> </ul> <ul id="agencyLinks"> <li><a href="https://www.hhs.gov/">U.S. Department of Health and Human Services</a></li> <li><a href="https://www.nih.gov/">National Institutes of Health</a></li> <li><a href="https://www.cancer.gov/">National Cancer Institute</a></li> <li class="last"><a href="https://www.usa.gov/">USA.gov</a></li> </ul> <div id="bottomTagline">NIH… Turning Discovery Into Health<sup>®</sup></div> </div> </div> </body> </html>

CINXE.COM

Biometric Research Program (BRP)