CINXE.COM

<!DOCTYPE html> <html>  <head> <meta charset="UTF-8"> <meta http-equiv="Cache-Control" content="no-store"> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <title> KEGG PATHWAY: Methane metabolism - Reference pathway </title> <link rel="stylesheet" href="/css/kegg.css" type="text/css" /> <link rel="stylesheet" href="/css/jquery-ui.css" /> <style type="text/css">  </style> <script src="/js/jquery-3.1.0.min.js"></script> <script src="/js/jquery-ui.js"></script> <script src="/js/jquery.balloon.min.js"></script> <script src="/js/lz-string.min.js"></script> <script src="/kegg-bin/get_data.cgi?data=0021&id=show_pathway.merged.js&v2.11"></script> <script type="text/javascript">  </script> </head> <body>  <h1 class="page-title"> <a href="/kegg/pathway.html"><img alt="KEGG" border="0" src="/Fig/bget/kegg3.gif" /></a>  Methane metabolism - Reference pathway </h1>   <div class="nav"> [ <a href="/brite/query=00680&htext=br08901.keg&option=-a&node_proc=br08901_org&proc_enabled=map&panel=collapse" id="navPathwayMenu">Pathway menu</a> | <a id="navOrganismGroup" href="/kegg-bin/organism_stat?mapno=00680">Organism group</a> | <a href="/entry/map00680" id="navPathwayEntry">Pathway entry</a> | <a id="descLink" href="#description">Show description</a> | <a id="downloadMenu" href="#">Download</a> | <a href="javascript:void(window.open('/kegg/document/help_pathway.html','KEGG_Help','width=720,height=640'))">Help</a> ] <div id="description" class="hidden"> Methane is metabolized principally by methanotrophs and methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a metabolic byproduct. Methylotrophs, which are microorganisms that can obtain energy for growth by oxidizing one-carbon compounds, such as methanol and methane, are situated between methanotrophs and methanogens. Methanogens can obtain energy for growth by converting a limited number of substrates to methane under anaerobic conditions. Three types of methanogenic pathways are known: CO2 to methane [MD:<a href="/module/M00567">M00567</a>], methanol to methane [MD:<a href="/module/M00356">M00356</a>], and acetate to methane [MD:<a href="/module/M00357">M00357</a>]. Methanogens use 2-mercaptoethanesulfonate (CoM; coenzyme M) as the terminal methyl carrier in methanogenesis and have four enzymes for CoM biosynthesis [MD:<a href="/module/M00358">M00358</a>]. Coenzyme B-Coenzyme M heterodisulfide reductase (Hdr), requiring for the final reaction steps of methanogenic pathway, is divided into two types: cytoplasmic HdrABC in most methanogens and membrane-bound HdrED in Methanosarcina species. In methanotrophs and methyltrophs methane is oxidized to form formaldehyde, which is at the diverging point for further oxidation to CO2 for energy source and assimilation for biosynthesis. There are three pathways that convert formaldehyde to C2 or C3 compounds: serine pathway [MD:<a href="/module/M00346">M00346</a>], ribulose monophosphate pathway [MD:<a href="/module/M00345">M00345</a>], and xylulose monophosphate pathway [MD:<a href="/module/M00344">M00344</a>]. The first two pathways are found in prokaryotes and the third is found in yeast. As a special case of methylotrophs, various amines can be used as carbon sources in trimethylamine metabolism [MD:<a href="/module/M00563">M00563</a>]. </div>  <form name="selmenu" method="get"> <input type="button" id="changePathwayTypeButton" value="Change pathway type"> <input type="text" class="hidden" name="mapno" value="00680" /> <input type="text" class="hidden" id="scale" name="scale" value="1" /> <input type="text" class="hidden" id="displayNoColoringImage" name="nocolor" value="0" /> <input type="text" class="hidden" id="displayDescription" name="show_description" value="hide" /> <input type="text" class="hidden" id="displayControlPanel" name="show_module_list" value="show" /> <input type="text" class="hidden" id="clickableMode" name="clickable_mode" value="" /> <input type="text" class="hidden" name="module" value="" /> </form>  </div>   <div class="image-block" style="position:static;"> <img src="/kegg/pathway/map/map00680.png?1740569384309264" srcset="/kegg/pathway/map/map00680.png?1740569384309264 1x" data-srcset="/kegg/pathway/map/map00680.png 1x" id="pathwayimage" usemap="#mapdata" border="0" width="1307" /> <map id="mapdata" name="mapdata" data-scale="1"> <area id="22DC66FB" shape="circle" coords="165,96,4" class="original" href="/entry/C01438" title="C01438 (Methane)" data-entry="C01438" /> <area id="E36FC4C5" shape="circle" coords="165,201,4" class="original" href="/entry/C00132" title="C00132 (Methanol)" data-entry="C00132" /> <area id="E36FCECA" shape="circle" coords="165,411,4" class="original" href="/entry/C00067" title="C00067 (Formaldehyde)" data-entry="C00067" /> <area id="E46FD8D9" shape="circle" coords="165,642,4" class="original" href="/entry/C00058" title="C00058 (Formate)" data-entry="C00058" /> <area id="DF703D0B" shape="circle" coords="584,642,4" class="original" href="/entry/C00237" title="C00237 (CO)" data-entry="C00237" /> <area id="DE701975" shape="circle" coords="413,496,4" class="original" href="/entry/C04330" title="C04330 (5,10-Methenyltetrahydromethanopterin)" data-entry="C04330" /> <area id="01700061" shape="circle" coords="310,496,4" class="original" href="/entry/C01274" title="C01274 (5-Formyl-5,6,7,8-tetrahydromethanopterin)" data-entry="C01274" /> <area id="DE6FCF3D" shape="circle" coords="193,496,4" class="original" href="/entry/C01001" title="C01001 (Formylmethanofuran)" data-entry="C01001" /> <area id="DE704C0B" shape="circle" coords="673,496,4" class="original" href="/entry/C04488+C18799" title="C04488 (5-Methyl-5,6,7,8-tetrahydromethanopterin), C18799 (5-Methyl-H4SPT)" data-entry="C04488" /> <area id="F27032C0" shape="circle" coords="547,496,4" class="original" href="/entry/C04377" title="C04377 (5,10-Methylenetetrahydromethanopterin)" data-entry="C04377" /> <area id="E37041AC" shape="circle" coords="655,201,4" class="original" href="/entry/C03920" title="C03920 (2-(Methylthio)ethanesulfonate)" data-entry="C03920" /> <area id="FC702D34" shape="circle" coords="510,311,4" class="original" href="/entry/C00543" title="C00543 (Dimethylamine)" data-entry="C00543" /> <area id="E36FFBCA" shape="circle" coords="365,311,4" class="original" href="/entry/C00565" title="C00565 (Trimethylamine)" data-entry="C00565" /> <area id="E36FE2B1" shape="circle" coords="255,311,4" class="original" href="/entry/C01104" title="C01104 (Trimethylamine N-oxide)" data-entry="C01104" /> <area id="EE6FFBCA" shape="circle" coords="356,367,4" class="original" href="/entry/C01046" title="C01046 (N-Methyl-L-glutamate)" data-entry="C01046" /> <area id="E37046B1" shape="circle" coords="655,311,4" class="original" href="/entry/C00218" title="C00218 (Methylamine)" data-entry="C00218" /> <area id="ED6FD39D" shape="circle" coords="136,576,4" class="original" href="/entry/C01031" title="C01031 (S-Formylglutathione)" data-entry="C01031" /> <area id="EE6FCEA2" shape="circle" coords="136,487,4" class="original" href="/entry/C14180" title="C14180 (S-(Hydroxymethyl)glutathione)" data-entry="C14180" /> <area id="FD6FED06" shape="circle" coords="290,532,4" class="original" href="/entry/C00862" title="C00862 (Methanofuran)" data-entry="C00862" /> <area id="02703761" shape="circle" coords="520,547,4" class="original" href="/entry/C00876" title="C00876 (Coenzyme F420)" data-entry="C00876" /> <area id="E9701E8E" shape="circle" coords="435,547,4" class="original" href="/entry/C01080" title="C01080 (Reduced coenzyme F420)" data-entry="C01080" /> <area id="14E16791" shape="circle" coords="736,97,4" class="original" href="/entry/C04832" title="C04832 (Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide)" data-entry="C04832" /> <area id="EE7055A2" shape="circle" coords="736,187,4" class="original" href="/entry/C04628" title="C04628 (Coenzyme B)" data-entry="C04628" /> <area id="E870648E" shape="circle" coords="736,441,4" class="original" href="/entry/C01217+C18802" title="C01217 (5,6,7,8-Tetrahydromethanopterin), C18802 (Tetrahydrosarcinapterin)" data-entry="C01217" /> <area id="DF706F24" shape="circle" coords="794,642,4" class="original" href="/entry/C00024" title="C00024 (Acetyl-CoA)" data-entry="C00024" /> <area id="F370A124" shape="circle" coords="998,642,4" class="original" href="/entry/C00022" title="C00022 (Pyruvate)" data-entry="C00022" /> <area id="B3AF56E9" shape="circle" coords="1169,642,4" class="original" href="/entry/C00074" title="C00074 (Phosphoenolpyruvate)" data-entry="C00074" /> <area id="B9AF51D5" shape="circle" coords="1169,508,4" class="original" href="/entry/C00631" title="C00631 (2-Phospho-D-glycerate)" data-entry="C00631" /> <area id="B4AF47EE" shape="circle" coords="1169,353,4" class="original" href="/entry/C00197" title="C00197 (3-Phospho-D-glycerate)" data-entry="C00197" /> <area id="B4AF2EEE" shape="circle" coords="1069,353,4" class="original" href="/entry/C03232" title="C03232 (3-Phosphonooxypyruvate)" data-entry="C03232" /> <area id="F97091DE" shape="circle" coords="969,353,4" class="original" href="/entry/C01005" title="C01005 (O-Phospho-L-serine)" data-entry="C01005" /> <area id="EF707893" shape="circle" coords="837,353,4" class="original" href="/entry/C00065" title="C00065 (L-Serine)" data-entry="C00065" /> <area id="F070964D" shape="circle" coords="906,469,4" class="original" href="/entry/C00037" title="C00037 (Glycine)" data-entry="C00037" /> <area id="D870828E" shape="circle" coords="821,600,4" class="original" href="/entry/C04348" title="C04348 (L-Malyl-CoA)" data-entry="C04348" /> <area id="FE709B7A" shape="circle" coords="939,508,4" class="original" href="/entry/C00168" title="C00168 (Hydroxypyruvate)" data-entry="C00168" /> <area id="D6708261" shape="circle" coords="821,508,4" class="original" href="/entry/C00048" title="C00048 (Glyoxylate)" data-entry="C00048" /> <area id="A0AF38BC" shape="circle" coords="1054,508,4" class="original" href="/entry/C00258" title="C00258 (D-Glycerate)" data-entry="C00258" /> <area id="00709BAC" shape="circle" coords="939,600,4" class="original" href="/entry/C00149" title="C00149 ((S)-Malate)" data-entry="C00149" /> <area id="A2AF38E9" shape="circle" coords="1054,600,4" class="original" href="/entry/C00036" title="C00036 (Oxaloacetate)" data-entry="C00036" /> <area id="BBAF42F8" shape="circle" coords="1169,280,4" class="original" href="/entry/C00354" title="C00354 (D-Fructose 1,6-bisphosphate)" data-entry="C00354" /> <area id="B2AF3E02" shape="circle" coords="1169,191,4" class="original" href="/entry/C00085" title="C00085 (D-Fructose 6-phosphate)" data-entry="C00085" /> <area id="98AF24CB" shape="circle" coords="1052,140,4" class="original" href="/entry/C00199" title="C00199 (D-Ribulose 5-phosphate)" data-entry="C00199" /> <area id="BBAF29AD" shape="circle" coords="1039,280,4" class="original" href="/entry/C00111" title="C00111 (Glycerone phosphate)" data-entry="C00111" /> <area id="F07087D9" shape="circle" coords="967,144,4" class="original" href="/entry/C00231" title="C00231 (D-Xylulose 5-phosphate)" data-entry="C00231" /> <area id="A8AF29E9" shape="circle" coords="1066,246,4" class="original" href="/entry/C00118" title="C00118 (D-Glyceraldehyde 3-phosphate)" data-entry="C00118" /> <area id="05708C89" shape="circle" coords="930,280,4" class="original" href="/entry/C00184" title="C00184 (Glycerone)" data-entry="C00184" /> <area id="B3AF3DDA" shape="circle" coords="1169,112,4" class="original" href="/entry/C06019" title="C06019 (D-arabino-Hex-3-ulose 6-phosphate)" data-entry="C06019" /> <area id="D27055ED" shape="circle" coords="661,684,4" class="original" href="/entry/C00227" title="C00227 (Acetyl phosphate)" data-entry="C00227" /> <area id="F0703C89" shape="circle" coords="527,684,4" class="original" href="/entry/C00033" title="C00033 (Acetate)" data-entry="C00033" /> <area id="DC7091D9" shape="circle" coords="952,399,4" class="original" href="/entry/C00101" title="C00101 (Tetrahydrofolate)" data-entry="C00101" /> <area id="D77096C0" shape="circle" coords="952,444,4" class="original" href="/entry/C00143" title="C00143 (5,10-Methylenetetrahydrofolate)" data-entry="C00143" /> <area id="F8700AC0" shape="circle" coords="359,642,4" class="original" href="/entry/C00011" title="C00011 (CO2)" data-entry="C00011" /> <area id="FD708766" shape="circle" coords="930,112,4" class="original" href="/entry/C00067" title="C00067 (Formaldehyde)" data-entry="C00067" /> <area id="E870737A" shape="circle" coords="836,201,4" class="original" href="/entry/C03576" title="C03576 (Coenzyme M)" data-entry="C03576" /> <area id="DF7050C0" shape="circle" coords="653,547,4" class="original" href="/entry/C00876" title="C00876 (Coenzyme F420)" data-entry="C00876" /> <area id="F87037D9" shape="circle" coords="568,547,4" class="original" href="/entry/C01080" title="C01080 (Reduced coenzyme F420)" data-entry="C01080" /> <area id="9EAF7E8F" shape="circle" coords="1234,916,4" class="original" href="/entry/C00876" title="C00876 (Coenzyme F420)" data-entry="C00876" /> <area id="E8707D7F" shape="circle" coords="735,916,4" class="original" href="/entry/C04732" title="C04732 (5-Amino-6-(1-D-ribitylamino)uracil)" data-entry="C04732" /> <area id="E370AF4D" shape="circle" coords="914,916,4" class="original" href="/entry/C19154" title="C19154 (7,8-Didemethyl-8-hydroxy-5-deazariboflavin)" data-entry="C19154" /> <area id="CF70AAB1" shape="circle" coords="941,861,4" class="original" href="/entry/C19155" title="C19155 ((2S)-Lactyl-2-diphospho-5'-guanosine)" data-entry="C19155" /> <area id="D47091B1" shape="circle" coords="842,861,4" class="original" href="/entry/C19156" title="C19156 ((2S)-2-Phospholactate)" data-entry="C19156" /> <area id="B7AF6576" shape="circle" coords="1129,916,4" class="original" href="/entry/C19152" title="C19152 (Coenzyme F420-1)" data-entry="C19152" /> <area id="9CAF7EB2" shape="circle" coords="1233,989,4" class="original" href="/entry/C19151" title="C19151 (Coenzyme F420-3)" data-entry="C19151" /> <area id="9EAF4C76" shape="circle" coords="1024,916,4" class="original" href="/entry/C19153" title="C19153 (Coenzyme F420-0)" data-entry="C19153" /> <area id="E7702E38" shape="circle" coords="495,885,4" class="original" href="/entry/C00593" title="C00593 (Sulfoacetaldehyde)" data-entry="C00593" /> <area id="E770151F" shape="circle" coords="385,885,4" class="original" href="/entry/C05528" title="C05528 (3-Sulfopyruvate)" data-entry="C05528" /> <area id="E76FFC06" shape="circle" coords="275,885,4" class="original" href="/entry/C11537" title="C11537 ((2R)-3-Sulfolactate)" data-entry="C11537" /> <area id="E76FE2ED" shape="circle" coords="165,885,4" class="original" href="/entry/C11536" title="C11536 ((2R)-O-Phospho-3-sulfolactate)" data-entry="C11536" /> <area id="E770471F" shape="circle" coords="585,885,4" class="original" href="/entry/C03576" title="C03576 (Coenzyme M)" data-entry="C03576" /> <area id="17B4A35A" shape="circle" coords="55,885,4" class="original" href="/entry/C00074" title="C00074 (Phosphoenolpyruvate)" data-entry="C00074" /> <area id="ABAF74AD" shape="circle" coords="1237,774,4" class="original" href="/entry/C04628" title="C04628 (Coenzyme B)" data-entry="C04628" /> <area id="92AF5BC6" shape="circle" coords="1142,774,4" class="original" href="/entry/C16594" title="C16594 (7-Mercaptoheptanoylthreonine)" data-entry="C16594" /> <area id="B0AF42DF" shape="circle" coords="1058,774,4" class="original" href="/entry/C16593" title="C16593 (7-Mercaptoheptanoic acid)" data-entry="C16593" /> <area id="E170A601" shape="circle" coords="974,774,4" class="original" href="/entry/C16590" title="C16590 (7-Oxoheptanoic acid)" data-entry="C16590" /> <area id="FF708D1A" shape="circle" coords="890,774,4" class="original" href="/entry/C16589" title="C16589 (2-Oxosuberate)" data-entry="C16589" /> <area id="E66FDDE8" shape="circle" coords="165,774,4" class="original" href="/entry/C00322" title="C00322 (2-Oxoadipate)" data-entry="C00322" /> <area id="E66FF6CF" shape="circle" coords="255,774,4" class="original" href="/entry/C16583" title="C16583 ((R)-(Homo)2-citrate)" data-entry="C16583" /> <area id="E6700FB6" shape="circle" coords="345,774,4" class="original" href="/entry/C20581" title="C20581 (cis-(Homo)2-aconitate)" data-entry="C20581" /> <area id="E670289D" shape="circle" coords="435,774,4" class="original" href="/entry/C16597" title="C16597 ((-)-threo-Iso(homo)2-citrate)" data-entry="C16597" /> <area id="E6704184" shape="circle" coords="525,774,4" class="original" href="/entry/C16588" title="C16588 (2-Oxopimelate)" data-entry="C16588" /> <area id="E6705A6B" shape="circle" coords="615,774,4" class="original" href="/entry/C16598" title="C16598 ((R)-(Homo)3-citrate)" data-entry="C16598" /> <area id="E6707352" shape="circle" coords="705,774,4" class="original" href="/entry/C20582" title="C20582 (cis-(Homo)3-aconitate)" data-entry="C20582" /> <area id="E6707433" shape="circle" coords="795,774,4" class="original" href="/entry/C16600" title="C16600 ((-)-threo-Iso(homo)3-citrate)" data-entry="C16600" /> <area id="7845CEF8" shape="circle" coords="678,1022,4" class="original" href="/entry/C21070" title="C21070 ((4-{4-[2-(gamma-L-Glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine)" data-entry="C21070" /> <area id="F57019B6" shape="circle" coords="348,974,4" class="original" href="/entry/C00082" title="C00082 (L-Tyrosine)" data-entry="C00082" /> <area id="E6704C1A" shape="circle" coords="585,974,4" class="original" href="/entry/C20926" title="C20926 (gamma-Glutamyltyramine)" data-entry="C20926" /> <area id="EB7032E8" shape="circle" coords="466,974,4" class="original" href="/entry/C00483" title="C00483 (Tyramine)" data-entry="C00483" /> <area id="77C8B5AD" shape="circle" coords="165,1022,4" class="original" href="/entry/C00118" title="C00118 (D-Glyceraldehyde 3-phosphate)" data-entry="C00118" /> <area id="77E1E7AD" shape="circle" coords="285,1022,4" class="original" href="/entry/C20954" title="C20954 ((5-Formylfuran-3-yl)methyl phosphate)" data-entry="C20954" /> <area id="78131FAD" shape="circle" coords="405,1022,4" class="original" href="/entry/C21068" title="C21068 ([5-(Aminomethyl)furan-3-yl]methyl phosphate)" data-entry="C21068" /> <area id="782C6AF8" shape="circle" coords="538,1022,4" class="original" href="/entry/C21069" title="C21069 ([5-(Aminomethyl)furan-3-yl]methyl diphosphate)" data-entry="C21069" /> <area id="E3709666" shape="circle" coords="824,916,4" class="original" href="/entry/C21971" title="C21971 (5-Amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil)" data-entry="C21971" /> <area id="9FAF4C94" shape="circle" coords="1024,977,4" class="original" href="/entry/C22277" title="C22277 (Dehydro coenzyme F420-0)" data-entry="C22277" /> <area id="E470AF84" shape="circle" coords="924,977,4" class="original" href="/entry/C22297" title="C22297 (Enolpyruvoyl-2-diphospho-5'-guanosine)" data-entry="C22297" /> <area id="DA7096B6" shape="circle" coords="842,977,4" class="original" href="/entry/C00074" title="C00074 (Phosphoenolpyruvate)" data-entry="C00074" /> <area id="59A299E8" shape="rect" coords="117,132,163,149" class="original" href="/entry/K16157+K16158+K16159+K16160+K16161+K16162+1.14.13.25+R01142" title="K16157 (mmoX), K16158 (mmoY), K16159 (mmoZ), K16160 (mmoB), K16161 (mmoC), K16162 (mmoD), 1.14.13.25, R01142" /> <area id="5E89A61D" shape="rect" coords="167,132,213,149" class="original" href="/entry/K10944+K10945+K10946+1.14.18.3+R09518" title="K10944 (pmoA-amoA), K10945 (pmoB-amoB), K10946 (pmoC-amoC), 1.14.18.3, R09518" /> <area id="BEA7125F" shape="rect" coords="117,266,163,283" class="original" href="/entry/K17066+1.1.3.13+R00608" title="K17066 (MOX), 1.1.3.13, R00608" /> <area id="D7A51265" shape="rect" coords="117,247,163,264" class="original" href="/entry/K14028+K16254+K16255+K14029+K16256+K16257+K16258+K16259+K16260+1.1.2.7+R01146" title="K14028 (mdh1), K16254 (mxaJ), K16255 (mxaG), K14029 (mdh2), K16256 (mxaA), K16257 (mxaC), K16258 (mxaK), K16259 (mxaL), K16260 (mxaD), 1.1.2.7, R01146" /> <area id="C38E1E94" shape="rect" coords="167,266,213,283" class="original" href="/entry/K00093+1.1.1.244+R00605" title="K00093 (mdh), 1.1.1.244, R00605" /> <area id="D3AFADA9" shape="rect" coords="142,541,188,558" class="original" href="/entry/K00148+1.2.1.46+R00604" title="K00148 (fdhA), 1.2.1.46, R00604" /> <area id="7CB583BE" shape="rect" coords="247,623,293,640" class="original" href="/entry/K00122+K00123+K22515+K00124+K00127+K00126+1.17.1.9+R00519" title="K00122 (FDH), K00123 (fdoG), K22515 (fdwB), K00124 (fdoH), K00127 (fdoI), K00126 (fdsD), 1.17.1.9, R00519" /> <area id="16BC6C45" shape="rect" coords="450,634,496,651" class="original" href="/entry/K00192+K00195+K00196+K00198+1.2.7.4+R07157" title="K00192 (cdhA), K00195 (cdhB), K00196 (cooF), K00198 (cooS), 1.2.7.4, R07157" /> <area id="07896C22" shape="rect" coords="457,488,503,505" class="original" href="/entry/K00319+1.5.98.1+R04456" title="K00319 (mtd), 1.5.98.1, R04456" /> <area id="7AAEFB40" shape="rect" coords="338,488,384,505" class="original" href="/entry/K01499+3.5.4.27+R03464" title="K01499 (mch), 3.5.4.27, R03464" /> <area id="6EA79D31" shape="rect" coords="232,487,278,504" class="original" href="/entry/K00672+2.3.1.101+R03390" title="K00672 (ftr), 2.3.1.101, R03390" /> <area id="A288AA15" shape="rect" coords="170,600,216,617" class="original" href="/entry/K00200+K00201+K00202+K00203+K00204+K00205+K11261+K11260+1.2.7.12+R08060" title="K00200 (fwdA), K00201 (fwdB), K00202 (fwdC), K00203 (fwdD), K00204 (fwdH), K00205 (fwdF), K11261 (fwdE), K11260 (fwdG), 1.2.7.12, R08060" /> <area id="839AF37A" shape="rect" coords="590,488,636,505" class="original" href="/entry/K00320+1.5.98.2+R04464" title="K00320 (mer), 1.5.98.2, R04464" /> <area id="9AAB22CB" shape="rect" coords="224,569,270,586" class="original" href="/entry/K00200+K00201+K00202+K00203+K00204+K00205+K11261+K11260+1.2.7.12+R03015" title="K00200 (fwdA), K00201 (fwdB), K00202 (fwdC), K00203 (fwdD), K00204 (fwdH), K00205 (fwdF), K11261 (fwdE), K11260 (fwdG), 1.2.7.12, R03015" /> <area id="7EB3F1C0" shape="rect" coords="633,132,679,149" class="original" href="/entry/K00399+K00400+K00401+K00402+K03421+K03422+2.8.4.1+R04541" title="K00399 (mcrA), K00400 (K00400), K00401 (mcrB), K00402 (mcrG), K03421 (mcrC), K03422 (mcrD), 2.8.4.1, R04541" /> <area id="84B7681F" shape="rect" coords="743,192,789,209" class="original" href="/entry/K00577+K00578+K00579+K00580+K00581+K00582+K00583+K00584+7.2.1.4+R04347+R12291" title="K00577 (mtrA), K00578 (mtrB), K00579 (mtrC), K00580 (mtrD), K00581 (mtrE), K00582 (mtrF), K00583 (mtrG), K00584 (mtrH), 7.2.1.4, R04347, R12291" /> <area id="878C6B3A" shape="rect" coords="559,303,605,320" class="original" href="/entry/K00317+1.5.8.1+R01588" title="K00317 (dmd-tmd), 1.5.8.1, R01588" /> <area id="12A2FF67" shape="rect" coords="412,303,458,320" class="original" href="/entry/K00317+1.5.8.2+R02511" title="K00317 (dmd-tmd), 1.5.8.2, R02511" /> <area id="C79B96DE" shape="rect" coords="391,345,437,362" class="original" href="/entry/4.1.2.32+R02512" title="4.1.2.32, R02512" /> <area id="F594248D" shape="rect" coords="290,303,336,320" class="original" href="/entry/K18277+1.14.13.148+R05623" title="K18277 (tmm), 1.14.13.148, R05623" /> <area id="DC972504" shape="rect" coords="290,332,336,349" class="original" href="/entry/K07811+K03532+K03533+K07812+K07821+1.7.2.3+R02560" title="K07811 (torA), K03532 (torC), K03533 (torD), K07812 (torZ), K07821 (torY), 1.7.2.3, R02560" /> <area id="09B8143F" shape="rect" coords="249,359,295,376" class="original" href="/entry/K22084+K22085+K22086+K22087+1.5.99.5+R00609" title="K22084 (mgdA), K22085 (mgdB), K22086 (mgdC), K22087 (mgdD), 1.5.99.5, R00609" /> <area id="9BB05AE7" shape="rect" coords="518,359,564,376" class="original" href="/entry/K22081+K22082+K22083+2.1.1.21+R01586" title="K22081 (mgsA), K22082 (mgsB), K22083 (mgsC), 2.1.1.21, R01586" /> <area id="99B8EEB4" shape="rect" coords="633,373,679,390" class="original" href="/entry/K08685+K15228+K15229+1.4.9.1+R00606" title="K08685 (qhpA), K15228 (mauA), K15229 (mauB), 1.4.9.1, R00606" /> <area id="EB9D767C" shape="rect" coords="487,247,533,264" class="original" href="/entry/K14082+2.1.1.247+R09999" title="K14082 (mtbA), 2.1.1.247, R09999" /> <area id="17ABE0F8" shape="rect" coords="510,264,556,281" class="original" href="/entry/K16179+R09999" title="K16179 (mtbC), R09999" /> <area id="2990928F" shape="rect" coords="464,264,510,281" class="original" href="/entry/K16178+2.1.1.249+R09999" title="K16178 (mtbB), 2.1.1.249, R09999" /> <area id="458E9E1C" shape="rect" coords="279,201,325,218" class="original" href="/entry/K14081+R09098" title="K14081 (mtaC), R09098" /> <area id="19830A1D" shape="rect" coords="256,184,302,201" class="original" href="/entry/K14080+2.1.1.246+R09098" title="K14080 (mtaA), 2.1.1.246, R09098" /> <area id="52A7A849" shape="rect" coords="233,201,279,218" class="original" href="/entry/K04480+2.1.1.90+R09098" title="K04480 (mtaB), 2.1.1.90, R09098" /> <area id="FCB66A3D" shape="rect" coords="633,247,679,264" class="original" href="/entry/K14082+2.1.1.247+R09998" title="K14082 (mtbA), 2.1.1.247, R09998" /> <area id="9FAE4CF3" shape="rect" coords="609,264,655,281" class="original" href="/entry/K16176+2.1.1.248+R09998" title="K16176 (mtmB), 2.1.1.248, R09998" /> <area id="B095451E" shape="rect" coords="655,264,701,281" class="original" href="/entry/K16177+R09998" title="K16177 (mtmC), R09998" /> <area id="C2ABFE64" shape="rect" coords="319,266,365,283" class="original" href="/entry/K14083+2.1.1.250+R09124" title="K14083 (mttB), 2.1.1.250, R09124" /> <area id="A2B416AE" shape="rect" coords="342,249,388,266" class="original" href="/entry/K14082+2.1.1.247+R09124" title="K14082 (mtbA), 2.1.1.247, R09124" /> <area id="D392F68F" shape="rect" coords="365,266,411,283" class="original" href="/entry/K14084+R09124" title="K14084 (mttC), R09124" /> <area id="329CACD1" shape="rect" coords="113,600,159,617" class="original" href="/entry/K01070+3.1.2.12+R00527" title="K01070 (frmB), 3.1.2.12, R00527" /> <area id="9B9EA2E4" shape="rect" coords="113,514,159,531" class="original" href="/entry/K00121+1.1.1.284+R06983" title="K00121 (frmA), 1.1.1.284, R06983" /> <area id="17A02BE3" shape="rect" coords="113,439,159,456" class="original" href="/entry/K03396+4.4.1.22+R06982" title="K03396 (gfa), 4.4.1.22, R06982" /> <area id="C7BA7EB2" shape="rect" coords="247,666,293,683" class="original" href="/entry/K05299+K15022+1.17.1.10+R00134" title="K05299 (fdhA), K15022 (fdhB), 1.17.1.10, R00134" /> <area id="1E3DB1F1" shape="rect" coords="46,514,92,531" class="original" href="/entry/K17067+K17068+1.2.98.1+R00614" title="K17067 (mdo), K17068 (fdm), 1.2.98.1, R00614" /> <area id="D48F6829" shape="rect" coords="457,446,503,463" class="original" href="/entry/K00300+K10714+R08059" title="K00300 (mtdA), K10714 (mtdB), R08059" /> <area id="D4916923" shape="rect" coords="457,466,503,483" class="original" href="/entry/K13942+1.12.98.2+R04455" title="K13942 (hmd), 1.12.98.2, R04455" /> <area id="1A8EF1B6" shape="rect" coords="459,539,505,556" class="original" href="/entry/K00440+K00441+K00442+K00443+1.12.98.1+R03025" title="K00440 (frhA), K00441 (frhB), K00442 (frhD), K00443 (frhG), 1.12.98.1, R03025" /> <area id="3F9FDD87" shape="rect" coords="688,125,734,142" class="original" href="/entry/K08264+K08265+1.8.98.1+R04540" title="K08264 (hdrD), K08265 (hdrE), 1.8.98.1, R04540" /> <area id="44ACF25A" shape="rect" coords="523,420,569,437" class="original" href="/entry/K10713+K13812+4.2.1.147+R08058" title="K10713 (fae), K13812 (fae-hps), 4.2.1.147, R08058" /> <area id="24BC484C" shape="rect" coords="637,449,683,466" class="original" href="/entry/K00600+2.1.2.1+R09099" title="K00600 (glyA), 2.1.2.1, R09099" /> <area id="2EA24CF5" shape="rect" coords="882,633,928,650" class="original" href="/entry/K00169+K00170+K00172+K00189+K00171+1.2.7.1+R01196" title="K00169 (porA), K00170 (porB), K00172 (porC), K00189 (vorG), K00171 (porD), 1.2.7.1, R01196" /> <area id="014837C0" shape="rect" coords="1062,634,1108,651" class="original" href="/entry/K01007+2.7.9.2+R00199" title="K01007 (pps), 2.7.9.2, R00199" /> <area id="026742F5" shape="rect" coords="1146,559,1192,576" class="original" href="/entry/K01689+4.2.1.11+R00658" title="K01689 (ENO1_2_3), 4.2.1.11, R00658" /> <area id="00D1F0CC" shape="rect" coords="1121,425,1167,442" class="original" href="/entry/K01834+K15634+5.4.2.11+R01518" title="K01834 (PGAM), K15634 (gpmB), 5.4.2.11, R01518" /> <area id="FF491038" shape="rect" coords="1102,345,1148,362" class="original" href="/entry/K00058+1.1.1.95+R01513" title="K00058 (serA), 1.1.1.95, R01513" /> <area id="F7D808C7" shape="rect" coords="1001,345,1047,362" class="original" href="/entry/K00831+2.6.1.52+R04173" title="K00831 (serC), 2.6.1.52, R04173" /> <area id="4BB417F9" shape="rect" coords="908,345,954,362" class="original" href="/entry/K01079+K02203+K22305+K25528+3.1.3.3+R00582" title="K01079 (serB), K02203 (thrH), K22305 (psp), K25528 (ysaA), 3.1.3.3, R00582" /> <area id="00E46A0D" shape="rect" coords="1096,591,1142,608" class="original" href="/entry/K01595+4.1.1.31+R00345" title="K01595 (ppc), 4.1.1.31, R00345" /> <area id="A6C13E33" shape="rect" coords="850,499,896,516" class="original" href="/entry/K00830+2.6.1.45+R00588" title="K00830 (AGXT), 2.6.1.45, R00588" /> <area id="9A9C508B" shape="rect" coords="970,499,1016,516" class="original" href="/entry/K00018+1.1.1.29+R01388" title="K00018 (hprA), 1.1.1.29, R01388" /> <area id="9893C7FC" shape="rect" coords="861,592,907,609" class="original" href="/entry/K08692+K14067+6.2.1.9+R01256" title="K08692 (mtkB), K14067 (mtkA), 6.2.1.9, R01256" /> <area id="61AD47EC" shape="rect" coords="798,566,844,583" class="original" href="/entry/K08691+4.1.3.24+R00473" title="K08691 (mcl), 4.1.3.24, R00473" /> <area id="FF5C169D" shape="rect" coords="1083,499,1129,516" class="original" href="/entry/K11529+2.7.1.165+R08572" title="K11529 (gck), 2.7.1.165, R08572" /> <area id="9C1FC120" shape="rect" coords="980,592,1026,609" class="original" href="/entry/K00024+1.1.1.37+R00342" title="K00024 (mdh), 1.1.1.37, R00342" /> <area id="02E08FD1" shape="rect" coords="1199,236,1245,253" class="original" href="/entry/K03841+K02446+K11532+K01086+K04041+K01622+3.1.3.11+R00762" title="K03841 (FBP), K02446 (glpX), K11532 (glpX-SEBP), K01086 (fbp-SEBP), K04041 (fbp3), K01622 (K01622), 3.1.3.11, R00762" /> <area id="FDD673C7" shape="rect" coords="1121,215,1167,232" class="original" href="/entry/K24182+K00850+K16370+K21071+2.7.1.11+R00756" title="K24182 (PFK9), K00850 (pfkA), K16370 (pfkB), K21071 (pfk), 2.7.1.11, R00756" /> <area id="FC70C702" shape="rect" coords="1146,143,1192,160" class="original" href="/entry/K08094+K13831+5.3.1.27+R05339" title="K08094 (hxlB), K13831 (hps-phi), 5.3.1.27, R05339" /> <area id="F9DF2C61" shape="rect" coords="1078,104,1124,121" class="original" href="/entry/K08093+K13812+K13831+4.1.2.43+R05338" title="K08093 (hxlA), K13812 (fae-hps), K13831 (hps-phi), 4.1.2.43, R05338" /> <area id="FB6D1E49" shape="rect" coords="1090,272,1136,289" class="original" href="/entry/K01623+K01624+K01622+K11645+K16305+K16306+4.1.2.13+R01068" title="K01623 (ALDO), K01624 (FBA), K01622 (K01622), K11645 (fbaB), K16305 (K16305), K16306 (K16306), 4.1.2.13, R01068" /> <area id="50AD15E8" shape="rect" coords="906,185,952,202" class="original" href="/entry/K17100+2.2.1.3+R01440" title="K17100 (DAS), 2.2.1.3, R01440" /> <area id="96A0C75C" shape="rect" coords="956,272,1002,289" class="original" href="/entry/K00863+2.7.1.29+R01011" title="K00863 (DAK), 2.7.1.29, R01011" /> <area id="3FA05300" shape="rect" coords="884,414,930,431" class="original" href="/entry/K00600+2.1.2.1+R00945" title="K00600 (glyA), 2.1.2.1, R00945" /> <area id="6A9AF278" shape="rect" coords="572,676,618,693" class="original" href="/entry/K00925+2.7.2.1+R00315" title="K00925 (ackA), 2.7.2.1, R00315" /> <area id="57B3B975" shape="rect" coords="710,676,756,693" class="original" href="/entry/K00625+K13788+2.3.1.8+R00230" title="K00625 (pta), K13788 (pta), 2.3.1.8, R00230" /> <area id="D6B9CED5" shape="rect" coords="640,711,686,728" class="original" href="/entry/K01895+6.2.1.1+R00235" title="K01895 (ACSS1_2), 6.2.1.1, R00235" /> <area id="B4A07B66" shape="rect" coords="592,539,638,556" class="original" href="/entry/K00440+K00441+K00442+K00443+1.12.98.1+R03025" title="K00440 (frhA), K00441 (frhB), K00442 (frhD), K00443 (frhG), 1.12.98.1, R03025" /> <area id="8CC238CE" shape="rect" coords="750,908,796,925" class="original" href="/entry/K11781+K11779+2.5.1.147+R12161" title="K11781 (cofH), K11779 (fbiC), 2.5.1.147, R12161" /> <area id="2BC72C30" shape="rect" coords="953,908,999,925" class="original" href="/entry/K11212+2.7.8.28+R09398" title="K11212 (cofD), 2.7.8.28, R09398" /> <area id="8EA01F12" shape="rect" coords="865,852,911,869" class="original" href="/entry/K14941+2.7.7.68+R09397" title="K14941 (cofC), 2.7.7.68, R09397" /> <area id="00E2E6CB" shape="rect" coords="1049,908,1095,925" class="original" href="/entry/K12234+K24998+6.3.2.31+R09399" title="K12234 (cofE), K24998 (fbiB), 6.3.2.31, R09399" /> <area id="0D2948E9" shape="rect" coords="1157,908,1203,925" class="original" href="/entry/K12234+K24998+6.3.2.34+R09400" title="K12234 (cofE), K24998 (fbiB), 6.3.2.34, R09400" /> <area id="0FAE7DD8" shape="rect" coords="1211,941,1257,958" class="original" href="/entry/K14940+6.3.2.32+R09401" title="K14940 (cofF), 6.3.2.32, R09401" /> <area id="B8171119" shape="poly" coords="499,884,579,884,579,886,499,886" class="original" href="/entry/R09153" title="R09153" /> <area id="F4C1B135" shape="rect" coords="81,877,127,894" class="original" href="/entry/K08097+4.4.1.19+R07476" title="K08097 (comA), 4.4.1.19, R07476" /> <area id="F49C2955" shape="rect" coords="191,877,237,894" class="original" href="/entry/K05979+3.1.3.71+R05789" title="K05979 (comB), 3.1.3.71, R05789" /> <area id="F9A5F55C" shape="rect" coords="301,877,347,894" class="original" href="/entry/K05884+1.1.1.337+R07136" title="K05884 (comC), 1.1.1.337, R07136" /> <area id="7BAD6DD2" shape="rect" coords="412,877,458,894" class="original" href="/entry/K13039+K06034+K24393+4.1.1.79+R05774" title="K13039 (comE), K06034 (comD), K24393 (comDE), 4.1.1.79, R05774" /> <area id="EDC8BDEE" shape="poly" coords="1062,773,1136,773,1136,775,1062,775" class="original" href="/entry/R08323" title="R08323" /> <area id="452BF59F" shape="poly" coords="978,773,1052,773,1052,775,978,775" class="original" href="/entry/R10397" title="R10397" /> <area id="2820B674" shape="poly" coords="894,773,968,773,968,775,894,775" class="original" href="/entry/R08328" title="R08328" /> <area id="0A3AC09C" shape="rect" coords="1164,766,1210,783" class="original" href="/entry/R08217" title="R08217" /> <area id="5795AD6C" shape="rect" coords="182,766,228,783" class="original" href="/entry/K10977+R08331" title="K10977 (aksA), R08331" /> <area id="D99320FB" shape="rect" coords="273,766,319,783" class="original" href="/entry/K16792+K16793+4.2.1.114+R10392" title="K16792 (aksD), K16793 (aksE), 4.2.1.114, R10392" /> <area id="DE908F8A" shape="rect" coords="363,766,409,783" class="original" href="/entry/K16792+K16793+4.2.1.114+R10393" title="K16792 (aksD), K16793 (aksE), 4.2.1.114, R10393" /> <area id="61BFF919" shape="rect" coords="452,766,498,783" class="original" href="/entry/K10978+R08214" title="K10978 (aksF), R08214" /> <area id="60BD71AD" shape="rect" coords="544,766,590,783" class="original" href="/entry/K10977+R08332" title="K10977 (aksA), R08332" /> <area id="E8BADB37" shape="rect" coords="633,766,679,783" class="original" href="/entry/K16792+K16793+4.2.1.114+R10395" title="K16792 (aksD), K16793 (aksE), 4.2.1.114, R10395" /> <area id="6AB84ECB" shape="rect" coords="724,766,770,783" class="original" href="/entry/K16792+K16793+4.2.1.114+R10396" title="K16792 (aksD), K16793 (aksE), 4.2.1.114, R10396" /> <area id="6FB5BD5A" shape="rect" coords="814,766,860,783" class="original" href="/entry/K10978+R08215" title="K10978 (aksF), R08215" /> <area id="05C525CC" shape="rect" coords="1171,425,1217,442" class="original" href="/entry/K15633+K15635+5.4.2.12+R01518" title="K15633 (gpmI), K15635 (apgM), 5.4.2.12, R01518" /> <area id="519B730A" shape="rect" coords="378,966,424,983" class="original" href="/entry/K18933+4.1.1.25+R00736" title="K18933 (mfnA), 4.1.1.25, R00736" /> <area id="E5AA5CE4" shape="rect" coords="503,966,549,983" class="original" href="/entry/K06914+6.3.4.24+R10902" title="K06914 (mfnD), 6.3.4.24, R10902" /> <area id="8E59FAC7" shape="rect" coords="197,1014,243,1031" class="original" href="/entry/K09733+4.2.3.153+R10935" title="K09733 (mfnB), 4.2.3.153, R10935" /> <area id="66D1FAF9" shape="rect" coords="317,1014,363,1031" class="original" href="/entry/K19793+2.6.1.108+R11038" title="K19793 (mfnC), 2.6.1.108, R11038" /> <area id="E939371C" shape="rect" coords="443,1014,489,1031" class="original" href="/entry/K07144+2.7.4.31+R11039" title="K07144 (mfnE), 2.7.4.31, R11039" /> <area id="524B195D" shape="rect" coords="595,1014,641,1031" class="original" href="/entry/K07072+2.5.1.131+R11040" title="K07072 (mfnF), 2.5.1.131, R11040" /> <area id="02C9A8CC" shape="rect" coords="1171,215,1217,232" class="original" href="/entry/K00918+2.7.1.146+R05805" title="K00918 (pfkC), 2.7.1.146, R05805" /> <area id="64AA5B6C" shape="rect" coords="714,106,760,123" class="original" href="/entry/K22480+K22481+K22482+K03388+K03389+K03390+1.8.7.3+R11931" title="K22480 (hdrA1), K22481 (hdrB1), K22482 (hdrC1), K03388 (hdrA2), K03389 (hdrB2), K03390 (hdrC2), 1.8.7.3, R11931" /> <area id="3FBB4252" shape="rect" coords="738,125,784,142" class="original" href="/entry/K03388+K03389+K03390+1.8.98.4+R11928" title="K03388 (hdrA2), K03389 (hdrB2), K03390 (hdrC2), 1.8.98.4, R11928" /> <area id="26A1DD81" shape="rect" coords="688,144,734,161" class="original" href="/entry/K03388+K03389+K03390+K14126+K14128+K14127+1.8.98.5+R11943" title="K03388 (hdrA2), K03389 (hdrB2), K03390 (hdrC2), K14126 (mvhA), K14128 (mvhG), K14127 (mvhD), 1.8.98.5, R11943" /> <area id="26BD424C" shape="rect" coords="738,144,784,161" class="original" href="/entry/K03388+K03389+K03390+K14127+K22516+K00125+1.8.98.6+R11944" title="K03388 (hdrA2), K03389 (hdrB2), K03390 (hdrC2), K14127 (mvhD), K22516 (fdhA), K00125 (fdhB), 1.8.98.6, R11944" /> <area id="95B87BB8" shape="rect" coords="247,644,293,661" class="original" href="/entry/K22516+K00125+1.17.98.3+R10797" title="K22516 (fdhA), K00125 (fdhB), 1.17.98.3, R10797" /> <area id="A9BFB3BA" shape="rect" coords="842,908,888,925" class="original" href="/entry/K11780+K11779+4.3.1.32+R12162" title="K11780 (cofG), K11779 (fbiC), 4.3.1.32, R12162" /> <area id="DC8C1E9A" shape="rect" coords="167,247,213,264" class="original" href="/entry/K23995+1.1.2.10+R01146" title="K23995 (xoxF), 1.1.2.10, R01146" /> <area id="3D9E61F5" shape="rect" coords="682,634,728,651" class="original" href="/entry/K00193+K00197+K00194+R09096+R10219" title="K00193 (cdhC), K00197 (cdhE), K00194 (cdhD), R09096, R10219" /> <area id="44CD301E" shape="rect" coords="953,969,999,986" class="original" href="/entry/K11212+2.7.8.28+R12648" title="K11212 (cofD), 2.7.8.28, R12648" /> <area id="00C51449" shape="rect" coords="1002,941,1048,958" class="original" href="/entry/K24998+1.3.8.17+R12720" title="K24998 (fbiB), 1.3.8.17, R12720" /> <area id="389DA128" shape="rect" coords="857,969,903,986" class="original" href="/entry/K14941+2.7.7.105+R12646" title="K14941 (cofC), 2.7.7.105, R12646" /> <area id="E1B280AC" shape="rect" coords="247,687,293,704" class="original" href="/entry/K22015+K25123+K25124+R12754" title="K22015 (fdhF), K25123 (hydA2), K25124 (hycB), R12754" /> <area id="37B2ABC9" shape="rect" coords="41,46,222,71" class="original" href="/entry/map00680" title="map00680: Methane metabolism" data-entry="map00680" /> <area id="9FA2C739" shape="rect" coords="660,329,732,363" class="original" href="/pathway/map00790" title="map00790: Folate biosynthesis" data-entry="map00790" /> <area id="9B29B1E5" shape="rect" coords="915,544,1070,578" class="original" href="/pathway/map00630" title="map00630: Glyoxylate and dicarboxylate metabolism" data-entry="map00630" /> <area id="9B18E5C7" shape="rect" coords="846,669,1005,703" class="original" href="/pathway/map00630" title="map00630: Glyoxylate and dicarboxylate metabolism" data-entry="map00630" /> <area id="FE41966D" shape="rect" coords="1016,430,1108,455" class="original" href="/pathway/map00720" title="map00720: Other carbon fixation pathways" data-entry="map00720" /> <area id="5DC23072" shape="rect" coords="871,300,991,334" class="original" href="/pathway/map00260" title="map00260: Glycine, serine and threonine metabolism" data-entry="map00260" /> <area id="9B250944" shape="rect" coords="996,170,1101,205" class="original" href="/pathway/map00030" title="map00030: Pentose phosphate pathway" data-entry="map00030" /> <area id="83BB1E72" shape="rect" coords="805,232,871,266" class="original" href="/pathway/map00920" title="map00920: Sulfur metabolism" data-entry="map00920" /> <area id="13860A4C" shape="rect" coords="127,699,203,733" class="original" href="/pathway/map00910" title="map00910: Nitrogen metabolism" data-entry="map00910" /> <area id="B8C0433D" shape="rect" coords="622,899,695,933" class="original" href="/pathway/map00740" title="map00740: Riboflavin metabolism" data-entry="map00740" /> <area id="F4C10E8B" shape="rect" coords="49,758,122,792" class="original" href="/pathway/map00300" title="map00300: Lysine biosynthesis" data-entry="map00300" /> <area id="6CBD074E" shape="rect" coords="224,957,298,991" class="original" href="/pathway/map00300" title="map00300: Lysine biosynthesis" data-entry="map00300" /> <area id="FD989E6E" shape="rect" coords="47,1010,120,1035" class="original" href="/pathway/map00010" title="map00010: Glycolysis / Gluconeogenesis" data-entry="map00010" /> </map> <map id="module_mapdata" name="module_mapdata" data-scale="1"> <area shape="poly" coords="589,640,704,640,704,642,589,642" href="javascript:void(0)" data-refid="D318AAF1" data-module="M00422" class="module" /> <area shape="poly" coords="589,641,597,637,597,644" href="javascript:void(0)" data-refid="B7F4CB77" data-module="M00422" class="module" /> <area shape="poly" coords="829,199,747,199,747,201,829,201" href="javascript:void(0)" data-refid="C81DE5A7" data-module="M00567" class="module" /> <area shape="poly" coords="829,200,820,203,820,196" href="javascript:void(0)" data-refid="59186B03" data-module="M00567" class="module" /> <area shape="poly" coords="917,914,1017,914,1017,916,917,916" href="javascript:void(0)" data-refid="66146C17" data-module="M00378" class="module" /> <area shape="poly" coords="1017,915,1008,918,1008,911" href="javascript:void(0)" data-refid="CAFBA00E" data-module="M00378" class="module" /> <area shape="poly" coords="738,914,817,914,817,916,738,916" href="javascript:void(0)" data-refid="CD1F1E4F" data-module="M00378" class="module" /> <area shape="poly" coords="817,915,808,918,808,911" href="javascript:void(0)" data-refid="1C59BE5D" data-module="M00378" class="module" /> <area shape="poly" coords="734,100,734,181,736,181,736,100" href="javascript:void(0)" data-refid="CB1AF51D" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="poly" coords="735,181,731,172,738,172" href="javascript:void(0)" data-refid="38D68FB8" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="poly" coords="819,596,819,513,821,513,821,596" href="javascript:void(0)" data-refid="D91F88CB" data-module="M00346" class="module" /> <area shape="poly" coords="820,513,823,521,816,521" href="javascript:void(0)" data-refid="FD4A3F26" data-module="M00346" class="module" /> <area shape="poly" coords="1167,194,1167,272,1169,272,1169,194" href="javascript:void(0)" data-refid="FB4CB0CD" data-module="M00345" class="module" /> <area shape="poly" coords="1168,272,1164,263,1171,263" href="javascript:void(0)" data-refid="139B8EAC" data-module="M00345" class="module" /> <area shape="poly" coords="660,199,791,199,791,199,793,199,792,200,793,201,794,200,796,200,795,201,796,202,796,202,797,203,797,203,798,204,798,204,798,206,798,206,799,207,799,207,799,209,799,209,799,486,799,486,799,487,799,487,798,489,798,489,798,490,798,490,797,491,797,491,796,493,796,493,795,494,796,493,794,493,793,494,792,495,793,494,791,494,791,494,678,494,678,496,791,496,791,496,793,496,794,495,795,494,794,495,796,495,797,494,798,493,798,493,799,491,799,491,800,490,800,490,800,489,800,489,801,487,801,487,801,486,801,486,801,209,801,209,801,207,801,207,800,206,800,206,800,204,800,204,799,203,799,203,798,202,798,202,797,201,796,202,794,202,795,201,794,200,793,201,791,201,791,201,660,201" href="javascript:void(0)" data-refid="5CC90111" data-module="M00567+M00357" class="module" /> <area shape="poly" coords="678,495,686,491,686,498" href="javascript:void(0)" data-refid="590A469F" data-module="M00567+M00357" class="module" /> <area shape="poly" coords="660,200,668,196,668,203" href="javascript:void(0)" data-refid="0662E586" data-module="M00567+M00357" class="module" /> <area shape="poly" coords="734,152,734,161,734,161,734,163,734,163,735,164,735,164,735,166,735,166,736,167,737,166,739,167,738,168,739,169,740,168,741,168,741,168,743,169,743,169,744,169,744,169,826,169,826,169,827,169,827,169,829,170,829,170,830,170,829,171,830,172,831,171,833,172,832,173,833,174,833,174,833,176,833,176,834,177,834,177,834,179,834,179,834,194,836,194,836,179,836,179,836,177,836,177,835,176,835,176,835,174,835,174,834,173,833,174,831,173,832,172,831,171,830,172,829,172,829,172,827,171,827,171,826,171,826,171,744,171,744,171,743,171,743,171,741,170,741,170,740,170,741,169,740,168,739,169,737,168,738,167,737,166,737,166,737,164,737,164,736,163,736,163,736,161,736,161,736,152" href="javascript:void(0)" data-refid="3318065A" data-module="M00567+M00357" class="module" /> <area shape="poly" coords="835,194,831,185,838,185" href="javascript:void(0)" data-refid="F26930F4" data-module="M00567+M00357" class="module" /> <area shape="poly" coords="727,94,663,94,663,94,661,94,660,95,659,96,660,95,658,95,657,96,656,97,656,97,655,99,655,99,654,100,654,100,654,101,654,101,653,103,653,103,653,104,653,104,653,177,653,177,653,179,653,179,654,180,654,180,654,182,654,182,655,183,655,183,656,184,656,184,657,185,658,184,660,184,659,185,660,186,661,185,663,185,663,185,730,185,730,187,663,187,663,187,661,187,662,186,661,185,660,186,658,186,659,185,658,184,658,184,657,183,657,183,656,182,656,182,656,180,656,180,655,179,655,179,655,177,655,177,655,104,655,104,655,103,655,103,656,101,656,101,656,100,656,100,657,99,657,99,658,97,658,97,659,96,658,97,660,97,661,96,662,95,661,96,663,96,663,96,727,96" href="javascript:void(0)" data-refid="60C31F10" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="poly" coords="726,95,718,98,718,91" href="javascript:void(0)" data-refid="7683566A" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="poly" coords="508,306,508,221,508,221,508,219,508,219,509,218,509,218,509,216,509,216,510,215,511,214,513,213,512,214,513,213,514,212,515,212,515,212,517,211,517,211,518,211,518,211,648,211,648,213,518,213,518,213,517,213,517,213,515,214,515,214,514,214,515,213,514,214,513,215,511,216,512,215,511,216,511,216,511,218,511,218,510,219,510,219,510,221,510,221,510,306" href="javascript:void(0)" data-refid="5650C7EA" data-module="M00563" class="module" /> <area shape="poly" coords="648,212,639,215,639,208" href="javascript:void(0)" data-refid="0782DD86" data-module="M00563" class="module" /> <area shape="circle" coords="164,95,4" href="javascript:void(0)" data-refid="22DC66FB" data-module="M00567+M00356+M00563+M00174+M00357" class="module" /> <area shape="poly" coords="163,194,163,99,165,99,165,194" href="javascript:void(0)" data-refid="64A502FC" data-module="M00174" class="module" /> <area shape="poly" coords="164,194,160,185,167,185" href="javascript:void(0)" data-refid="1781783C" data-module="M00174" class="module" /> <area shape="rect" coords="116,131,162,148" href="javascript:void(0)" data-refid="59A299E8" data-module="M00174" class="module" /> <area shape="rect" coords="166,131,212,148" href="javascript:void(0)" data-refid="5E89A61D" data-module="M00174" class="module" /> <area shape="circle" coords="164,200,4" href="javascript:void(0)" data-refid="E36FC4C5" data-module="M00356+M00174" class="module" /> <area shape="circle" coords="164,410,4" href="javascript:void(0)" data-refid="E36FCECA" data-module="M00174" class="module" /> <area shape="poly" coords="163,204,163,404,165,404,165,204" href="javascript:void(0)" data-refid="B00C4C93" data-module="M00174" class="module" /> <area shape="poly" coords="164,404,160,395,167,395" href="javascript:void(0)" data-refid="88A2785F" data-module="M00174" class="module" /> <area shape="rect" coords="116,246,162,263" href="javascript:void(0)" data-refid="D7A51265" data-module="M00174" class="module" /> <area shape="poly" coords="364,640,577,640,577,642,364,642" href="javascript:void(0)" data-refid="711392B4" data-module="M00422" class="module" /> <area shape="poly" coords="577,641,568,644,568,637" href="javascript:void(0)" data-refid="AA399B77" data-module="M00422" class="module" /> <area shape="poly" coords="364,641,372,637,372,644" href="javascript:void(0)" data-refid="304737FA" data-module="M00422" class="module" /> <area shape="circle" coords="583,641,4" href="javascript:void(0)" data-refid="DF703D0B" data-module="M00422" class="module" /> <area shape="rect" coords="449,633,495,650" href="javascript:void(0)" data-refid="16BC6C45" data-module="M00422" class="module" /> <area shape="poly" coords="303,494,198,494,198,496,303,496" href="javascript:void(0)" data-refid="61121ECA" data-module="M00567" class="module" /> <area shape="poly" coords="303,495,294,498,294,491" href="javascript:void(0)" data-refid="5CDBE0DC" data-module="M00567" class="module" /> <area shape="poly" coords="196,501,196,567,196,567,196,569,196,569,197,570,197,570,197,572,197,572,198,573,198,573,199,574,199,574,200,575,201,574,203,574,202,575,203,576,204,575,206,575,206,575,349,575,349,575,351,575,350,576,351,577,352,576,354,576,353,577,354,578,354,578,355,579,355,579,356,580,356,580,356,582,356,582,357,583,357,583,357,585,357,585,357,635,359,635,359,585,359,585,359,583,359,583,358,582,358,582,358,580,358,580,357,579,357,579,356,578,356,578,355,577,354,578,352,578,353,577,352,576,351,577,349,577,349,577,206,577,206,577,204,577,205,576,204,575,203,576,201,576,202,575,201,574,201,574,200,573,200,573,199,572,199,572,199,570,199,570,198,569,198,569,198,567,198,567,198,501" href="javascript:void(0)" data-refid="A37595E3" data-module="M00567" class="module" /> <area shape="poly" coords="197,501,200,509,193,509" href="javascript:void(0)" data-refid="CB96186E" data-module="M00567" class="module" /> <area shape="poly" coords="540,494,416,494,416,496,540,496" href="javascript:void(0)" data-refid="E01754BC" data-module="M00567" class="module" /> <area shape="poly" coords="540,495,531,498,531,491" href="javascript:void(0)" data-refid="7A7DBC5E" data-module="M00567" class="module" /> <area shape="circle" coords="412,495,4" href="javascript:void(0)" data-refid="DE701975" data-module="M00567" class="module" /> <area shape="poly" coords="406,494,315,494,315,496,406,496" href="javascript:void(0)" data-refid="C914C107" data-module="M00567" class="module" /> <area shape="poly" coords="315,495,323,491,323,498" href="javascript:void(0)" data-refid="E79A20DC" data-module="M00567" class="module" /> <area shape="poly" coords="406,495,397,498,397,491" href="javascript:void(0)" data-refid="1402061D" data-module="M00567" class="module" /> <area shape="circle" coords="309,495,4" href="javascript:void(0)" data-refid="01700061" data-module="M00567" class="module" /> <area shape="rect" coords="456,487,502,504" href="javascript:void(0)" data-refid="07896C22" data-module="M00567" class="module" /> <area shape="rect" coords="337,487,383,504" href="javascript:void(0)" data-refid="7AAEFB40" data-module="M00567" class="module" /> <area shape="circle" coords="192,495,4" href="javascript:void(0)" data-refid="DE6FCF3D" data-module="M00567" class="module" /> <area shape="rect" coords="231,486,277,503" href="javascript:void(0)" data-refid="6EA79D31" data-module="M00567" class="module" /> <area shape="poly" coords="550,494,665,494,665,496,550,496" href="javascript:void(0)" data-refid="DB1789AA" data-module="M00567" class="module" /> <area shape="poly" coords="665,495,656,498,656,491" href="javascript:void(0)" data-refid="4B2B4F9F" data-module="M00567" class="module" /> <area shape="circle" coords="672,495,4" href="javascript:void(0)" data-refid="DE704C0B" data-module="M00567+M00357" class="module" /> <area shape="rect" coords="589,487,635,504" href="javascript:void(0)" data-refid="839AF37A" data-module="M00567" class="module" /> <area shape="rect" coords="223,568,269,585" href="javascript:void(0)" data-refid="9AAB22CB" data-module="M00567" class="module" /> <area shape="circle" coords="546,495,4" href="javascript:void(0)" data-refid="F27032C0" data-module="M00567" class="module" /> <area shape="circle" coords="654,200,4" href="javascript:void(0)" data-refid="E37041AC" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="poly" coords="170,94,645,94,645,94,647,94,646,95,647,96,648,95,650,95,649,96,650,97,650,97,651,99,651,99,652,100,652,100,652,101,652,101,653,103,653,103,653,104,653,104,653,197,655,197,655,104,655,104,655,103,655,103,654,101,654,101,654,100,654,100,653,99,653,99,652,97,652,97,651,96,650,97,648,97,649,96,648,95,647,96,645,96,645,96,170,96" href="javascript:void(0)" data-refid="283409B6" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="poly" coords="170,95,178,91,178,98" href="javascript:void(0)" data-refid="9CBC46A7" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="rect" coords="632,131,678,148" href="javascript:void(0)" data-refid="7EB3F1C0" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="rect" coords="742,191,788,208" href="javascript:void(0)" data-refid="84B7681F" data-module="M00567+M00357" class="module" /> <area shape="circle" coords="509,310,4" href="javascript:void(0)" data-refid="FC702D34" data-module="M00563" class="module" /> <area shape="circle" coords="364,310,4" href="javascript:void(0)" data-refid="E36FFBCA" data-module="M00563" class="module" /> <area shape="poly" coords="167,199,648,199,648,201,167,201" href="javascript:void(0)" data-refid="D30CBF66" data-module="M00356" class="module" /> <area shape="poly" coords="648,200,639,203,639,196" href="javascript:void(0)" data-refid="03FCC786" data-module="M00356" class="module" /> <area shape="rect" coords="486,246,532,263" href="javascript:void(0)" data-refid="EB9D767C" data-module="M00563" class="module" /> <area shape="rect" coords="509,263,555,280" href="javascript:void(0)" data-refid="17ABE0F8" data-module="M00563" class="module" /> <area shape="rect" coords="463,263,509,280" href="javascript:void(0)" data-refid="2990928F" data-module="M00563" class="module" /> <area shape="rect" coords="278,200,324,217" href="javascript:void(0)" data-refid="458E9E1C" data-module="M00356" class="module" /> <area shape="rect" coords="255,183,301,200" href="javascript:void(0)" data-refid="19830A1D" data-module="M00356" class="module" /> <area shape="rect" coords="232,200,278,217" href="javascript:void(0)" data-refid="52A7A849" data-module="M00356" class="module" /> <area shape="circle" coords="654,310,4" href="javascript:void(0)" data-refid="E37046B1" data-module="M00563" class="module" /> <area shape="poly" coords="653,305,653,206,655,206,655,305" href="javascript:void(0)" data-refid="CB196F09" data-module="M00563" class="module" /> <area shape="poly" coords="654,206,657,214,650,214" href="javascript:void(0)" data-refid="12238986" data-module="M00563" class="module" /> <area shape="rect" coords="632,246,678,263" href="javascript:void(0)" data-refid="FCB66A3D" data-module="M00563" class="module" /> <area shape="rect" coords="608,263,654,280" href="javascript:void(0)" data-refid="9FAE4CF3" data-module="M00563" class="module" /> <area shape="rect" coords="654,263,700,280" href="javascript:void(0)" data-refid="B095451E" data-module="M00563" class="module" /> <area shape="poly" coords="363,306,363,215,363,215,363,213,363,213,364,212,364,212,364,210,364,210,365,209,365,209,366,208,366,208,367,207,368,206,370,206,369,207,370,206,371,205,373,205,373,205,648,205,648,207,373,207,373,207,371,207,372,206,371,207,370,208,368,208,369,207,368,208,368,208,367,209,367,209,366,210,366,210,366,212,366,212,365,213,365,213,365,215,365,215,365,306" href="javascript:void(0)" data-refid="98915E32" data-module="M00563" class="module" /> <area shape="poly" coords="648,206,639,209,639,202" href="javascript:void(0)" data-refid="0502FF86" data-module="M00563" class="module" /> <area shape="rect" coords="318,265,364,282" href="javascript:void(0)" data-refid="C2ABFE64" data-module="M00563" class="module" /> <area shape="rect" coords="341,248,387,265" href="javascript:void(0)" data-refid="A2B416AE" data-module="M00563" class="module" /> <area shape="rect" coords="364,265,410,282" href="javascript:void(0)" data-refid="D392F68F" data-module="M00563" class="module" /> <area shape="poly" coords="414,489,414,479,414,479,414,478,414,478,414,477,414,477,415,476,415,476,416,475,416,475,417,474,417,474,418,473,419,472,420,472,420,472,421,472,421,472,531,472,531,472,532,472,532,472,533,472,532,473,533,474,533,474,534,475,534,475,535,476,535,476,536,477,536,477,536,478,536,478,536,479,536,479,536,489,538,489,538,479,538,479,538,478,538,478,538,477,538,477,537,476,537,476,536,475,536,475,535,474,535,474,534,473,533,474,532,474,532,474,531,474,531,474,421,474,421,474,420,474,420,474,419,474,420,473,419,474,419,474,418,475,418,475,417,476,417,476,416,477,416,477,416,478,416,478,416,479,416,479,416,489" href="javascript:void(0)" data-refid="2677853D" data-module="M00567" class="module" /> <area shape="poly" coords="537,489,533,480,540,480" href="javascript:void(0)" data-refid="6C221F5E" data-module="M00567" class="module" /> <area shape="poly" coords="415,488,411,480,418,480" href="javascript:void(0)" data-refid="9B93721D" data-module="M00567" class="module" /> <area shape="rect" coords="456,465,502,482" href="javascript:void(0)" data-refid="D4916923" data-module="M00567" class="module" /> <area shape="circle" coords="735,96,4" href="javascript:void(0)" data-refid="14E16791" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="circle" coords="735,186,4" href="javascript:void(0)" data-refid="EE7055A2" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="rect" coords="687,124,733,141" href="javascript:void(0)" data-refid="3F9FDD87" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="poly" coords="904,473,904,498,904,498,904,499,904,499,903,501,903,501,903,502,903,502,902,503,902,503,900,505,900,505,899,506,900,505,899,505,899,505,897,506,897,506,896,506,896,506,847,506,847,506,845,506,844,507,843,506,844,505,842,505,841,506,840,505,840,505,839,503,839,503,838,502,838,502,838,501,838,501,837,499,837,499,837,498,837,498,837,355,839,355,839,498,839,498,839,499,839,499,840,501,840,501,840,502,840,502,841,503,841,503,842,505,842,505,843,506,842,507,844,507,845,506,846,507,845,508,847,508,847,508,896,508,896,508,897,508,897,508,899,507,899,507,900,507,901,506,902,505,902,505,904,503,904,503,905,502,905,502,905,501,905,501,906,499,906,499,906,498,906,498,906,473" href="javascript:void(0)" data-refid="F3AE9F89" data-module="M00346" class="module" /> <area shape="poly" coords="905,473,908,481,901,481" href="javascript:void(0)" data-refid="1F62A05D" data-module="M00346" class="module" /> <area shape="poly" coords="842,357,896,357,896,357,897,357,897,357,899,358,899,358,900,358,899,359,900,360,901,359,903,360,902,361,903,362,903,362,903,364,903,364,904,365,904,365,904,367,904,367,904,463,906,463,906,367,906,367,906,365,906,365,905,364,905,364,905,362,905,362,904,361,903,362,901,361,902,360,901,359,900,360,899,360,899,360,897,359,897,359,896,359,896,359,842,359" href="javascript:void(0)" data-refid="CBBAA78C" data-module="M00346" class="module" /> <area shape="poly" coords="842,358,850,354,850,361" href="javascript:void(0)" data-refid="0B759412" data-module="M00346" class="module" /> <area shape="poly" coords="1164,351,1074,351,1074,353,1164,353" href="javascript:void(0)" data-refid="E8449E1E" data-module="M00020" class="module" /> <area shape="poly" coords="1074,352,1082,348,1082,355" href="javascript:void(0)" data-refid="02F1E367" data-module="M00020" class="module" /> <area shape="circle" coords="793,641,4" href="javascript:void(0)" data-refid="DF706F24" data-module="M00422+M00357" class="module" /> <area shape="circle" coords="1168,641,4" href="javascript:void(0)" data-refid="B3AF56E9" data-module="M00346" class="module" /> <area shape="poly" coords="1167,635,1167,513,1169,513,1169,635" href="javascript:void(0)" data-refid="FEBAD22C" data-module="M00346" class="module" /> <area shape="poly" coords="1168,513,1171,521,1164,521" href="javascript:void(0)" data-refid="9F0DF2EF" data-module="M00346" class="module" /> <area shape="poly" coords="1168,635,1164,626,1171,626" href="javascript:void(0)" data-refid="071336EF" data-module="M00346" class="module" /> <area shape="rect" coords="1145,558,1191,575" href="javascript:void(0)" data-refid="026742F5" data-module="M00346" class="module" /> <area shape="circle" coords="1168,507,4" href="javascript:void(0)" data-refid="B9AF51D5" data-module="M00346" class="module" /> <area shape="circle" coords="1168,352,4" href="javascript:void(0)" data-refid="B4AF47EE" data-module="M00020" class="module" /> <area shape="circle" coords="1068,352,4" href="javascript:void(0)" data-refid="B4AF2EEE" data-module="M00020" class="module" /> <area shape="rect" coords="1101,344,1147,361" href="javascript:void(0)" data-refid="FF491038" data-module="M00020" class="module" /> <area shape="poly" coords="1064,351,974,351,974,353,1064,353" href="javascript:void(0)" data-refid="B7B5B664" data-module="M00020" class="module" /> <area shape="poly" coords="974,352,982,348,982,355" href="javascript:void(0)" data-refid="E88BC44E" data-module="M00020" class="module" /> <area shape="circle" coords="968,352,4" href="javascript:void(0)" data-refid="F97091DE" data-module="M00020" class="module" /> <area shape="rect" coords="1000,344,1046,361" href="javascript:void(0)" data-refid="F7D808C7" data-module="M00020" class="module" /> <area shape="poly" coords="964,351,842,351,842,353,964,353" href="javascript:void(0)" data-refid="7220FDEB" data-module="M00020" class="module" /> <area shape="poly" coords="842,352,850,348,850,355" href="javascript:void(0)" data-refid="0B4D5612" data-module="M00020" class="module" /> <area shape="rect" coords="907,344,953,361" href="javascript:void(0)" data-refid="4BB417F9" data-module="M00020" class="module" /> <area shape="circle" coords="836,352,4" href="javascript:void(0)" data-refid="EF707893" data-module="M00346+M00020" class="module" /> <area shape="poly" coords="824,506,932,506,932,508,824,508" href="javascript:void(0)" data-refid="F41F9D84" data-module="M00346" class="module" /> <area shape="poly" coords="931,507,923,510,923,503" href="javascript:void(0)" data-refid="BE0E1267" data-module="M00346" class="module" /> <area shape="poly" coords="942,506,1047,506,1047,508,942,508" href="javascript:void(0)" data-refid="66272322" data-module="M00346" class="module" /> <area shape="poly" coords="1047,507,1038,510,1038,503" href="javascript:void(0)" data-refid="1F117723" data-module="M00346" class="module" /> <area shape="poly" coords="934,598,826,598,826,600,934,600" href="javascript:void(0)" data-refid="3C21FC73" data-module="M00346" class="module" /> <area shape="poly" coords="826,599,834,595,834,602" href="javascript:void(0)" data-refid="135EFB2B" data-module="M00346" class="module" /> <area shape="poly" coords="944,598,1049,598,1049,600,944,600" href="javascript:void(0)" data-refid="722B8E2B" data-module="M00346" class="module" /> <area shape="poly" coords="944,599,952,595,952,602" href="javascript:void(0)" data-refid="E3B38D67" data-module="M00346" class="module" /> <area shape="poly" coords="1162,506,1057,506,1057,508,1162,508" href="javascript:void(0)" data-refid="FD3C3462" data-module="M00346" class="module" /> <area shape="poly" coords="1162,507,1153,510,1153,503" href="javascript:void(0)" data-refid="12E7E27A" data-module="M00346" class="module" /> <area shape="poly" coords="1059,598,1154,598,1154,598,1155,598,1155,598,1157,599,1157,599,1158,599,1157,600,1158,601,1158,601,1160,603,1160,603,1161,604,1161,604,1161,605,1161,605,1162,607,1162,607,1162,608,1162,608,1162,636,1164,636,1164,608,1164,608,1164,607,1164,607,1163,605,1163,605,1163,604,1163,604,1162,603,1162,603,1160,601,1160,601,1159,600,1158,601,1157,601,1157,601,1155,600,1155,600,1154,600,1154,600,1059,600" href="javascript:void(0)" data-refid="CB893B5F" data-module="M00346" class="module" /> <area shape="poly" coords="1059,599,1067,595,1067,602" href="javascript:void(0)" data-refid="AB211CA4" data-module="M00346" class="module" /> <area shape="rect" coords="1095,590,1141,607" href="javascript:void(0)" data-refid="00E46A0D" data-module="M00346" class="module" /> <area shape="rect" coords="849,498,895,515" href="javascript:void(0)" data-refid="A6C13E33" data-module="M00346" class="module" /> <area shape="rect" coords="969,498,1015,515" href="javascript:void(0)" data-refid="9A9C508B" data-module="M00346" class="module" /> <area shape="rect" coords="860,591,906,608" href="javascript:void(0)" data-refid="9893C7FC" data-module="M00346" class="module" /> <area shape="rect" coords="797,565,843,582" href="javascript:void(0)" data-refid="61AD47EC" data-module="M00346" class="module" /> <area shape="rect" coords="1082,498,1128,515" href="javascript:void(0)" data-refid="FF5C169D" data-module="M00346" class="module" /> <area shape="rect" coords="979,591,1025,608" href="javascript:void(0)" data-refid="9C1FC120" data-module="M00346" class="module" /> <area shape="circle" coords="905,468,4" href="javascript:void(0)" data-refid="F070964D" data-module="M00346" class="module" /> <area shape="circle" coords="820,599,4" href="javascript:void(0)" data-refid="D870828E" data-module="M00346" class="module" /> <area shape="circle" coords="938,507,4" href="javascript:void(0)" data-refid="FE709B7A" data-module="M00346" class="module" /> <area shape="circle" coords="820,507,4" href="javascript:void(0)" data-refid="D6708261" data-module="M00346" class="module" /> <area shape="circle" coords="1053,507,4" href="javascript:void(0)" data-refid="A0AF38BC" data-module="M00346" class="module" /> <area shape="circle" coords="938,599,4" href="javascript:void(0)" data-refid="00709BAC" data-module="M00346" class="module" /> <area shape="circle" coords="1053,599,4" href="javascript:void(0)" data-refid="A2AF38E9" data-module="M00346" class="module" /> <area shape="poly" coords="1172,278,1212,278,1212,278,1213,278,1213,278,1215,277,1215,277,1216,277,1215,278,1216,277,1216,277,1218,275,1218,275,1219,274,1219,274,1219,273,1219,273,1220,271,1220,271,1220,270,1220,270,1220,199,1220,199,1220,197,1220,197,1219,196,1219,196,1219,194,1219,194,1218,193,1219,192,1217,191,1216,192,1215,191,1216,190,1215,190,1215,190,1213,189,1213,189,1212,189,1212,189,1174,189,1174,191,1212,191,1212,191,1213,191,1213,191,1215,192,1215,192,1216,192,1217,191,1218,192,1217,193,1219,194,1220,193,1221,194,1221,194,1221,196,1221,196,1222,197,1222,197,1222,199,1222,199,1222,270,1222,270,1222,271,1222,271,1221,273,1221,273,1221,274,1221,274,1220,275,1220,275,1218,277,1218,277,1217,278,1216,279,1215,279,1215,279,1213,280,1213,280,1212,280,1212,280,1172,280" href="javascript:void(0)" data-refid="5BEEB973" data-module="M00344" class="module" /> <area shape="poly" coords="1174,190,1182,186,1182,193" href="javascript:void(0)" data-refid="87E8B299" data-module="M00344" class="module" /> <area shape="poly" coords="1167,116,1167,185,1169,185,1169,116" href="javascript:void(0)" data-refid="FE48C4CC" data-module="M00345" class="module" /> <area shape="poly" coords="1168,185,1164,176,1171,176" href="javascript:void(0)" data-refid="7EDB6887" data-module="M00345" class="module" /> <area shape="poly" coords="928,116,928,273,930,273,930,116" href="javascript:void(0)" data-refid="6B200C1A" data-module="M00344" class="module" /> <area shape="poly" coords="929,273,925,264,932,264" href="javascript:void(0)" data-refid="22D15044" data-module="M00344" class="module" /> <area shape="poly" coords="1033,278,933,278,933,280,1033,280" href="javascript:void(0)" data-refid="EBB52DB1" data-module="M00344" class="module" /> <area shape="poly" coords="1033,279,1024,282,1024,275" href="javascript:void(0)" data-refid="5A2CDC3A" data-module="M00344" class="module" /> <area shape="circle" coords="1168,279,4" href="javascript:void(0)" data-refid="BBAF42F8" data-module="M00345+M00344" class="module" /> <area shape="circle" coords="1168,190,4" href="javascript:void(0)" data-refid="B2AF3E02" data-module="M00345+M00344" class="module" /> <area shape="rect" coords="1198,235,1244,252" href="javascript:void(0)" data-refid="02E08FD1" data-module="M00344" class="module" /> <area shape="rect" coords="1120,214,1166,231" href="javascript:void(0)" data-refid="FDD673C7" data-module="M00345" class="module" /> <area shape="rect" coords="1145,142,1191,159" href="javascript:void(0)" data-refid="FC70C702" data-module="M00345" class="module" /> <area shape="poly" coords="1162,110,933,110,933,112,1162,112" href="javascript:void(0)" data-refid="9EB720F3" data-module="M00345" class="module" /> <area shape="poly" coords="1162,111,1153,114,1153,107" href="javascript:void(0)" data-refid="691B1C70" data-module="M00345" class="module" /> <area shape="poly" coords="1050,133,1050,120,1050,120,1050,119,1050,119,1051,117,1051,117,1051,116,1051,116,1052,115,1052,115,1054,113,1054,113,1055,112,1056,111,1057,111,1057,111,1059,110,1059,110,1060,110,1060,110,1072,110,1072,112,1060,112,1060,112,1059,112,1059,112,1057,113,1057,113,1056,113,1057,112,1056,113,1056,113,1054,115,1054,115,1053,116,1053,116,1053,117,1053,117,1052,119,1052,119,1052,120,1052,120,1052,133" href="javascript:void(0)" data-refid="45A1766C" data-module="M00345" class="module" /> <area shape="circle" coords="1051,139,4" href="javascript:void(0)" data-refid="98AF24CB" data-module="M00345" class="module" /> <area shape="rect" coords="1077,103,1123,120" href="javascript:void(0)" data-refid="F9DF2C61" data-module="M00345" class="module" /> <area shape="poly" coords="1064,251,1064,270,1064,270,1064,271,1064,271,1065,273,1065,273,1065,274,1065,274,1066,275,1066,275,1068,277,1068,277,1069,278,1070,277,1071,277,1071,277,1073,278,1073,278,1074,278,1074,278,1161,278,1161,280,1074,280,1074,280,1073,280,1073,280,1071,279,1071,279,1070,279,1071,278,1070,277,1070,277,1068,275,1068,275,1067,274,1067,274,1067,273,1067,273,1066,271,1066,271,1066,270,1066,270,1066,251" href="javascript:void(0)" data-refid="DA713812" data-module="M00345" class="module" /> <area shape="poly" coords="1161,278,1152,282,1152,275" href="javascript:void(0)" data-refid="FA7F9444" data-module="M00345" class="module" /> <area shape="poly" coords="1065,251,1068,259,1061,259" href="javascript:void(0)" data-refid="E7E27009" data-module="M00345" class="module" /> <area shape="circle" coords="1038,279,4" href="javascript:void(0)" data-refid="BBAF29AD" data-module="M00344" class="module" /> <area shape="poly" coords="1043,278,1161,278,1161,280,1043,280" href="javascript:void(0)" data-refid="DD52CB09" data-module="M00344" class="module" /> <area shape="poly" coords="1161,279,1152,282,1152,275" href="javascript:void(0)" data-refid="6B7F9453" data-module="M00344" class="module" /> <area shape="poly" coords="1043,279,1051,275,1051,282" href="javascript:void(0)" data-refid="B7110748" data-module="M00344" class="module" /> <area shape="circle" coords="1065,245,4" href="javascript:void(0)" data-refid="A8AF29E9" data-module="M00345" class="module" /> <area shape="circle" coords="929,279,4" href="javascript:void(0)" data-refid="05708C89" data-module="M00344" class="module" /> <area shape="rect" coords="1089,271,1135,288" href="javascript:void(0)" data-refid="FB6D1E49" data-module="M00345+M00344" class="module" /> <area shape="rect" coords="905,184,951,201" href="javascript:void(0)" data-refid="50AD15E8" data-module="M00344" class="module" /> <area shape="rect" coords="955,271,1001,288" href="javascript:void(0)" data-refid="96A0C75C" data-module="M00344" class="module" /> <area shape="circle" coords="1168,111,4" href="javascript:void(0)" data-refid="B3AF3DDA" data-module="M00345" class="module" /> <area shape="rect" coords="883,413,929,430" href="javascript:void(0)" data-refid="3FA05300" data-module="M00346" class="module" /> <area shape="poly" coords="525,689,525,709,525,709,525,711,525,711,526,712,526,712,526,714,526,714,527,715,527,715,528,716,528,716,529,717,530,716,532,716,531,717,532,718,533,717,535,717,535,717,784,717,784,717,785,717,785,717,787,716,787,716,788,716,787,717,788,716,789,715,791,714,790,715,791,714,791,714,791,712,791,712,792,711,792,711,792,709,792,709,792,647,794,647,794,709,794,709,794,711,794,711,793,712,793,712,793,714,793,714,792,715,791,716,789,717,790,716,789,717,788,718,787,718,787,718,785,719,785,719,784,719,784,719,535,719,535,719,533,719,534,718,533,717,532,718,530,718,531,717,530,716,530,716,529,715,529,715,528,714,528,714,528,712,528,712,527,711,527,711,527,709,527,709,527,689" href="javascript:void(0)" data-refid="C32C1EAD" data-module="M00357" class="module" /> <area shape="poly" coords="793,647,796,655,789,655" href="javascript:void(0)" data-refid="321C8FF9" data-module="M00357" class="module" /> <area shape="poly" coords="526,689,529,697,522,697" href="javascript:void(0)" data-refid="75779877" data-module="M00357" class="module" /> <area shape="poly" coords="666,682,779,682,779,682,781,682,780,683,781,682,782,681,784,681,783,682,784,681,784,681,785,679,785,679,786,678,786,678,786,677,786,677,787,675,787,675,787,674,787,674,787,647,789,647,789,674,789,674,789,675,789,675,788,677,788,677,788,678,788,678,787,679,787,679,786,681,786,681,785,682,784,683,782,683,783,682,782,683,781,684,779,684,779,684,666,684" href="javascript:void(0)" data-refid="1FA7B895" data-module="M00357" class="module" /> <area shape="poly" coords="788,647,791,655,784,655" href="javascript:void(0)" data-refid="26220EF9" data-module="M00357" class="module" /> <area shape="poly" coords="666,683,674,679,674,686" href="javascript:void(0)" data-refid="5F91BCB8" data-module="M00357" class="module" /> <area shape="circle" coords="660,683,4" href="javascript:void(0)" data-refid="D27055ED" data-module="M00357" class="module" /> <area shape="poly" coords="532,682,654,682,654,684,532,684" href="javascript:void(0)" data-refid="9C188832" data-module="M00357" class="module" /> <area shape="poly" coords="654,683,645,686,645,679" href="javascript:void(0)" data-refid="51D68CB8" data-module="M00357" class="module" /> <area shape="poly" coords="532,683,540,679,540,686" href="javascript:void(0)" data-refid="8239E077" data-module="M00357" class="module" /> <area shape="rect" coords="571,675,617,692" href="javascript:void(0)" data-refid="6A9AF278" data-module="M00357" class="module" /> <area shape="rect" coords="709,675,755,692" href="javascript:void(0)" data-refid="57B3B975" data-module="M00357" class="module" /> <area shape="circle" coords="526,683,4" href="javascript:void(0)" data-refid="F0703C89" data-module="M00357" class="module" /> <area shape="rect" coords="639,710,685,727" href="javascript:void(0)" data-refid="D6B9CED5" data-module="M00357" class="module" /> <area shape="circle" coords="358,641,4" href="javascript:void(0)" data-refid="F8700AC0" data-module="M00567+M00422" class="module" /> <area shape="circle" coords="929,111,4" href="javascript:void(0)" data-refid="FD708766" data-module="M00345+M00344" class="module" /> <area shape="circle" coords="835,200,4" href="javascript:void(0)" data-refid="E870737A" data-module="M00567+M00357" class="module" /> <area shape="poly" coords="1132,914,1227,914,1227,916,1132,916" href="javascript:void(0)" data-refid="FD29A322" data-module="M00378" class="module" /> <area shape="poly" coords="1227,915,1218,918,1218,911" href="javascript:void(0)" data-refid="527AF3FE" data-module="M00378" class="module" /> <area shape="poly" coords="939,865,939,906,939,906,939,907,939,907,940,909,940,909,940,910,940,910,941,911,941,911,942,913,942,913,943,914,944,913,946,913,945,914,946,915,947,914,949,914,949,914,972,914,972,916,949,916,949,916,947,916,948,915,947,914,946,915,944,915,945,914,944,913,944,913,943,911,943,911,942,910,942,910,942,909,942,909,941,907,941,907,941,906,941,906,941,865" href="javascript:void(0)" data-refid="182CB7C8" data-module="M00378" class="module" /> <area shape="circle" coords="1233,915,4" href="javascript:void(0)" data-refid="9EAF7E8F" data-module="M00378" class="module" /> <area shape="circle" coords="734,915,4" href="javascript:void(0)" data-refid="E8707D7F" data-module="M00378" class="module" /> <area shape="circle" coords="913,915,4" href="javascript:void(0)" data-refid="E370AF4D" data-module="M00378" class="module" /> <area shape="rect" coords="749,907,795,924" href="javascript:void(0)" data-refid="8CC238CE" data-module="M00378" class="module" /> <area shape="rect" coords="952,907,998,924" href="javascript:void(0)" data-refid="2BC72C30" data-module="M00378" class="module" /> <area shape="circle" coords="940,860,4" href="javascript:void(0)" data-refid="CF70AAB1" data-module="M00378" class="module" /> <area shape="poly" coords="845,859,934,859,934,861,845,861" href="javascript:void(0)" data-refid="C5212B72" data-module="M00378" class="module" /> <area shape="poly" coords="934,860,925,863,925,856" href="javascript:void(0)" data-refid="6E4AEC8F" data-module="M00378" class="module" /> <area shape="circle" coords="841,860,4" href="javascript:void(0)" data-refid="D47091B1" data-module="M00378" class="module" /> <area shape="rect" coords="864,851,910,868" href="javascript:void(0)" data-refid="8EA01F12" data-module="M00378" class="module" /> <area shape="poly" coords="1027,914,1122,914,1122,916,1027,916" href="javascript:void(0)" data-refid="E1B62557" data-module="M00378" class="module" /> <area shape="poly" coords="1122,915,1113,918,1113,911" href="javascript:void(0)" data-refid="41CCCE5C" data-module="M00378" class="module" /> <area shape="rect" coords="1048,907,1094,924" href="javascript:void(0)" data-refid="00E2E6CB" data-module="M00378" class="module" /> <area shape="circle" coords="1128,915,4" href="javascript:void(0)" data-refid="B7AF6576" data-module="M00378" class="module" /> <area shape="rect" coords="1156,907,1202,924" href="javascript:void(0)" data-refid="0D2948E9" data-module="M00378" class="module" /> <area shape="circle" coords="1023,915,4" href="javascript:void(0)" data-refid="9EAF4C76" data-module="M00378" class="module" /> <area shape="poly" coords="498,883,578,883,578,885,498,885" href="javascript:void(0)" data-refid="B8171119" data-module="M00358" class="module" /> <area shape="poly" coords="578,884,569,887,569,880" href="javascript:void(0)" data-refid="CA7AE990" data-module="M00358" class="module" /> <area shape="circle" coords="494,884,4" href="javascript:void(0)" data-refid="E7702E38" data-module="M00358" class="module" /> <area shape="poly" coords="388,883,488,883,488,885,388,885" href="javascript:void(0)" data-refid="B81484C1" data-module="M00358" class="module" /> <area shape="poly" coords="488,884,479,887,479,880" href="javascript:void(0)" data-refid="2031E954" data-module="M00358" class="module" /> <area shape="circle" coords="384,884,4" href="javascript:void(0)" data-refid="E770151F" data-module="M00358" class="module" /> <area shape="poly" coords="278,883,378,883,378,885,278,885" href="javascript:void(0)" data-refid="B811F837" data-module="M00358" class="module" /> <area shape="poly" coords="378,884,369,887,369,880" href="javascript:void(0)" data-refid="5C7AE913" data-module="M00358" class="module" /> <area shape="circle" coords="274,884,4" href="javascript:void(0)" data-refid="E76FFC06" data-module="M00358" class="module" /> <area shape="poly" coords="168,883,268,883,268,885,168,885" href="javascript:void(0)" data-refid="B80F6BAD" data-module="M00358" class="module" /> <area shape="poly" coords="268,884,259,887,259,880" href="javascript:void(0)" data-refid="98C3E8D2" data-module="M00358" class="module" /> <area shape="circle" coords="164,884,4" href="javascript:void(0)" data-refid="E76FE2ED" data-module="M00358" class="module" /> <area shape="poly" coords="58,883,158,883,158,885,58,885" href="javascript:void(0)" data-refid="E1D3A58A" data-module="M00358" class="module" /> <area shape="poly" coords="158,884,149,887,149,880" href="javascript:void(0)" data-refid="D50CE891" data-module="M00358" class="module" /> <area shape="rect" coords="80,876,126,893" href="javascript:void(0)" data-refid="F4C1B135" data-module="M00358" class="module" /> <area shape="rect" coords="190,876,236,893" href="javascript:void(0)" data-refid="F49C2955" data-module="M00358" class="module" /> <area shape="rect" coords="300,876,346,893" href="javascript:void(0)" data-refid="F9A5F55C" data-module="M00358" class="module" /> <area shape="rect" coords="411,876,457,893" href="javascript:void(0)" data-refid="7BAD6DD2" data-module="M00358" class="module" /> <area shape="circle" coords="584,884,4" href="javascript:void(0)" data-refid="E770471F" data-module="M00358" class="module" /> <area shape="circle" coords="54,884,4" href="javascript:void(0)" data-refid="17B4A35A" data-module="M00358" class="module" /> <area shape="poly" coords="168,772,248,772,248,774,168,774" href="javascript:void(0)" data-refid="9E0EE8F9" data-module="M00608" class="module" /> <area shape="poly" coords="248,773,239,776,239,769" href="javascript:void(0)" data-refid="F1C767C3" data-module="M00608" class="module" /> <area shape="circle" coords="889,773,4" href="javascript:void(0)" data-refid="FF708D1A" data-module="M00608" class="module" /> <area shape="circle" coords="164,773,4" href="javascript:void(0)" data-refid="E66FDDE8" data-module="M00608" class="module" /> <area shape="rect" coords="181,765,227,782" href="javascript:void(0)" data-refid="5795AD6C" data-module="M00608" class="module" /> <area shape="circle" coords="254,773,4" href="javascript:void(0)" data-refid="E66FF6CF" data-module="M00608" class="module" /> <area shape="poly" coords="258,772,338,772,338,774,258,774" href="javascript:void(0)" data-refid="9E11706F" data-module="M00608" class="module" /> <area shape="poly" coords="338,773,329,776,329,769" href="javascript:void(0)" data-refid="9C106804" data-module="M00608" class="module" /> <area shape="rect" coords="272,765,318,782" href="javascript:void(0)" data-refid="D99320FB" data-module="M00608" class="module" /> <area shape="circle" coords="344,773,4" href="javascript:void(0)" data-refid="E6700FB6" data-module="M00608" class="module" /> <area shape="poly" coords="348,772,428,772,428,774,348,774" href="javascript:void(0)" data-refid="9E13F7E5" data-module="M00608" class="module" /> <area shape="poly" coords="428,773,419,776,419,769" href="javascript:void(0)" data-refid="46596845" data-module="M00608" class="module" /> <area shape="rect" coords="362,765,408,782" href="javascript:void(0)" data-refid="DE908F8A" data-module="M00608" class="module" /> <area shape="circle" coords="434,773,4" href="javascript:void(0)" data-refid="E670289D" data-module="M00608" class="module" /> <area shape="poly" coords="438,772,518,772,518,774,438,774" href="javascript:void(0)" data-refid="9E167F5B" data-module="M00608" class="module" /> <area shape="poly" coords="518,773,509,776,509,769" href="javascript:void(0)" data-refid="F0A26881" data-module="M00608" class="module" /> <area shape="rect" coords="451,765,497,782" href="javascript:void(0)" data-refid="61BFF919" data-module="M00608" class="module" /> <area shape="circle" coords="524,773,4" href="javascript:void(0)" data-refid="E6704184" data-module="M00608" class="module" /> <area shape="poly" coords="528,772,608,772,608,774,528,774" href="javascript:void(0)" data-refid="9E1906D1" data-module="M00608" class="module" /> <area shape="poly" coords="608,773,599,776,599,769" href="javascript:void(0)" data-refid="1DFF68C2" data-module="M00608" class="module" /> <area shape="rect" coords="543,765,589,782" href="javascript:void(0)" data-refid="60BD71AD" data-module="M00608" class="module" /> <area shape="circle" coords="614,773,4" href="javascript:void(0)" data-refid="E6705A6B" data-module="M00608" class="module" /> <area shape="poly" coords="618,772,698,772,698,774,618,774" href="javascript:void(0)" data-refid="9E1B7641" data-module="M00608" class="module" /> <area shape="poly" coords="698,773,689,776,689,769" href="javascript:void(0)" data-refid="0D5A68C7" data-module="M00608" class="module" /> <area shape="rect" coords="632,765,678,782" href="javascript:void(0)" data-refid="E8BADB37" data-module="M00608" class="module" /> <area shape="circle" coords="704,773,4" href="javascript:void(0)" data-refid="E6707352" data-module="M00608" class="module" /> <area shape="poly" coords="708,772,788,772,788,774,708,774" href="javascript:void(0)" data-refid="9E1DFDB7" data-module="M00608" class="module" /> <area shape="poly" coords="788,773,779,776,779,769" href="javascript:void(0)" data-refid="B7A36903" data-module="M00608" class="module" /> <area shape="rect" coords="723,765,769,782" href="javascript:void(0)" data-refid="6AB84ECB" data-module="M00608" class="module" /> <area shape="circle" coords="794,773,4" href="javascript:void(0)" data-refid="E6707433" data-module="M00608" class="module" /> <area shape="poly" coords="798,772,883,772,883,774,798,774" href="javascript:void(0)" data-refid="851E2CB0" data-module="M00608" class="module" /> <area shape="poly" coords="883,773,874,776,874,769" href="javascript:void(0)" data-refid="6E63D644" data-module="M00608" class="module" /> <area shape="rect" coords="813,765,859,782" href="javascript:void(0)" data-refid="6FB5BD5A" data-module="M00608" class="module" /> <area shape="circle" coords="677,1021,4" href="javascript:void(0)" data-refid="7845CEF8" data-module="M00935" class="module" /> <area shape="poly" coords="671,1020,541,1020,541,1022,671,1022" href="javascript:void(0)" data-refid="72E332BF" data-module="M00935" class="module" /> <area shape="poly" coords="671,1021,662,1024,662,1017" href="javascript:void(0)" data-refid="51478659" data-module="M00935" class="module" /> <area shape="poly" coords="671,1020,593,1020,593,1020,591,1020,590,1021,589,1020,590,1019,588,1019,587,1020,586,1019,586,1019,585,1017,585,1017,584,1016,584,1016,584,1015,584,1015,583,1013,583,1013,583,1012,583,1012,583,979,585,979,585,1012,585,1012,585,1013,585,1013,586,1015,586,1015,586,1016,586,1016,587,1017,587,1017,588,1019,588,1019,589,1020,588,1021,590,1021,591,1020,592,1021,591,1022,593,1022,593,1022,671,1022" href="javascript:void(0)" data-refid="FA3AA5A1" data-module="M00935" class="module" /> <area shape="poly" coords="671,1021,662,1024,662,1017" href="javascript:void(0)" data-refid="51478659" data-module="M00935" class="module" /> <area shape="circle" coords="347,973,4" href="javascript:void(0)" data-refid="F57019B6" data-module="M00935" class="module" /> <area shape="circle" coords="584,973,4" href="javascript:void(0)" data-refid="E6704C1A" data-module="M00935" class="module" /> <area shape="poly" coords="461,972,351,972,351,974,461,974" href="javascript:void(0)" data-refid="10175903" data-module="M00935" class="module" /> <area shape="poly" coords="461,973,452,976,452,969" href="javascript:void(0)" data-refid="8EDC675E" data-module="M00935" class="module" /> <area shape="rect" coords="377,965,423,982" href="javascript:void(0)" data-refid="519B730A" data-module="M00935" class="module" /> <area shape="circle" coords="465,973,4" href="javascript:void(0)" data-refid="EB7032E8" data-module="M00935" class="module" /> <area shape="poly" coords="578,972,469,972,469,974,578,974" href="javascript:void(0)" data-refid="A319E59C" data-module="M00935" class="module" /> <area shape="poly" coords="578,973,569,976,569,969" href="javascript:void(0)" data-refid="52EC689F" data-module="M00935" class="module" /> <area shape="rect" coords="502,965,548,982" href="javascript:void(0)" data-refid="E5AA5CE4" data-module="M00935" class="module" /> <area shape="circle" coords="164,1021,4" href="javascript:void(0)" data-refid="77C8B5AD" data-module="M00935" class="module" /> <area shape="circle" coords="284,1021,4" href="javascript:void(0)" data-refid="77E1E7AD" data-module="M00935" class="module" /> <area shape="circle" coords="404,1021,4" href="javascript:void(0)" data-refid="78131FAD" data-module="M00935" class="module" /> <area shape="poly" coords="278,1020,168,1020,168,1022,278,1022" href="javascript:void(0)" data-refid="AE907C3C" data-module="M00935" class="module" /> <area shape="poly" coords="278,1021,269,1024,269,1017" href="javascript:void(0)" data-refid="C83E6D3E" data-module="M00935" class="module" /> <area shape="poly" coords="398,1020,288,1020,288,1022,398,1022" href="javascript:void(0)" data-refid="248BAE4B" data-module="M00935" class="module" /> <area shape="poly" coords="398,1021,389,1024,389,1017" href="javascript:void(0)" data-refid="0FC3F53E" data-module="M00935" class="module" /> <area shape="rect" coords="196,1013,242,1030" href="javascript:void(0)" data-refid="8E59FAC7" data-module="M00935" class="module" /> <area shape="rect" coords="316,1013,362,1030" href="javascript:void(0)" data-refid="66D1FAF9" data-module="M00935" class="module" /> <area shape="circle" coords="537,1021,4" href="javascript:void(0)" data-refid="782C6AF8" data-module="M00935" class="module" /> <area shape="poly" coords="531,1020,408,1020,408,1022,531,1022" href="javascript:void(0)" data-refid="F805CF5F" data-module="M00935" class="module" /> <area shape="poly" coords="531,1021,522,1024,522,1017" href="javascript:void(0)" data-refid="FF47E777" data-module="M00935" class="module" /> <area shape="rect" coords="442,1013,488,1030" href="javascript:void(0)" data-refid="E939371C" data-module="M00935" class="module" /> <area shape="rect" coords="594,1013,640,1030" href="javascript:void(0)" data-refid="524B195D" data-module="M00935" class="module" /> <area shape="rect" coords="713,105,759,122" href="javascript:void(0)" data-refid="64AA5B6C" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="rect" coords="737,124,783,141" href="javascript:void(0)" data-refid="3FBB4252" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="rect" coords="687,143,733,160" href="javascript:void(0)" data-refid="26A1DD81" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="rect" coords="737,143,783,160" href="javascript:void(0)" data-refid="26BD424C" data-module="M00567+M00356+M00563+M00357" class="module" /> <area shape="circle" coords="823,915,4" href="javascript:void(0)" data-refid="E3709666" data-module="M00378" class="module" /> <area shape="poly" coords="827,914,906,914,906,916,827,916" href="javascript:void(0)" data-refid="4B21A5C5" data-module="M00378" class="module" /> <area shape="poly" coords="906,915,897,918,897,911" href="javascript:void(0)" data-refid="49AA0799" data-module="M00378" class="module" /> <area shape="rect" coords="841,907,887,924" href="javascript:void(0)" data-refid="A9BFB3BA" data-module="M00378" class="module" /> <area shape="rect" coords="166,246,212,263" href="javascript:void(0)" data-refid="DC8C1E9A" data-module="M00174" class="module" /> <area shape="poly" coords="704,640,787,640,787,642,704,642" href="javascript:void(0)" data-refid="711D7A27" data-module="M00422+M00357" class="module" /> <area shape="poly" coords="787,641,778,644,778,637" href="javascript:void(0)" data-refid="24F09BF9" data-module="M00422+M00357" class="module" /> <area shape="poly" coords="671,501,671,632,671,632,671,633,671,633,672,635,672,635,672,636,672,636,673,637,673,637,674,639,674,639,675,640,676,639,678,639,677,640,678,641,679,640,681,640,681,640,704,640,704,642,681,642,681,642,679,642,680,641,679,640,678,641,676,641,677,640,676,639,676,639,675,637,675,637,674,636,674,636,674,635,674,635,673,633,673,633,673,632,673,632,673,501" href="javascript:void(0)" data-refid="57C42750" data-module="M00357" class="module" /> <area shape="poly" coords="672,501,675,509,668,509" href="javascript:void(0)" data-refid="CC4D9AA9" data-module="M00357" class="module" /> <area shape="rect" coords="681,633,727,650" href="javascript:void(0)" data-refid="3D9E61F5" data-module="M00422+M00357" class="module" /> </map> </div>   <div id="controlPanel"> <div class="controller"> <div class="feature option"> <h5>Option</h5> <div> <div class="row scale"> <span class="title">Scale:</span> <span class="content"> <input type="range" min="0.1" max="1" step="0.05" value="1"> <span class="label">100%</span> </span> </div> <div class="row image-resolution hidden"> <span class="title">Image resolution:</span> <span class="content"> <label> <input type="checkbox" value="high"> High </label> </span> </div> </div> </div> <div class="feature search"> <h5>Search</h5> <div> <div class="row query"> <form> <input type="text" name="query" style="width:130px;" autocomplete="off" value=""> <input type="submit" value="Go"> <span class="ui-icon button ui-icon-close clear-query hidden"></span> </form> </div> <div class="row result"> </div> </div> </div> <div class="feature search-pathway"> <h5>ID search <span class="ui-icon ui-icon-plus"></span> </h5> <div> <form> <div class="row" style="display:grid; grid-template-columns:135px 1fr; column-gap:5px;"> <div> <textarea class="query" rows="2" style="width:130px; resize:none;">C00227</textarea> </div> <div> <input type="submit" class="submit" value="Go"> <span class="ui-icon button ui-icon-close clear-query hidden"></span> </div> </div> </form> <div class="row personal hidden"> <ul class="mappers"></ul> </div> </div> </div> <div class="feature color-pathway"> <h5>Color <span class="ui-icon ui-icon-plus"></span> </h5> <div> <div class="row personal hidden"> <ul class="mappers"></ul> </div> </div> </div> <div class="feature color-module"> <h5>Module</h5> <div> <div class="row"> <ul class="tree module-tree hidden"> <li class="classification class-A "> <span> <input type="checkbox" > Pathway modules </span> <ul> <li class="classification class-B "> <span> <input type="checkbox" > Energy metabolism </span> <ul> <li class="classification class-C "> <span> <input type="checkbox" > Methane metabolism </span> <ul> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00567" data-entry="M00567" target="_blank" >M00567</a> Methanogenesis </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00357" data-entry="M00357" target="_blank" >M00357</a> Methanogenesis </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00356" data-entry="M00356" target="_blank" >M00356</a> Methanogenesis </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00563" data-entry="M00563" target="_blank" >M00563</a> Methanogenesis </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00358" data-entry="M00358" target="_blank" >M00358</a> Coenzyme M biosynthesis </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00608" data-entry="M00608" target="_blank" >M00608</a> 2-Oxocarboxylic acid chain extension </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00174" data-entry="M00174" target="_blank" >M00174</a> Methane oxidation, methanotroph </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00346" data-entry="M00346" target="_blank" >M00346</a> Formaldehyde assimilation, serine pathway </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00345" data-entry="M00345" target="_blank" >M00345</a> Formaldehyde assimilation, ribulose monophosphate pathway </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00344" data-entry="M00344" target="_blank" >M00344</a> Formaldehyde assimilation, xylulose monophosphate pathway </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00378" data-entry="M00378" target="_blank" >M00378</a> F420 biosynthesis, archaea </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00935" data-entry="M00935" target="_blank" >M00935</a> Methanofuran biosynthesis </span> </li> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00422" data-entry="M00422" target="_blank" >M00422</a> Acetyl-CoA pathway </span> </li> </ul> </li> </ul> </li> <li class="classification class-B "> <span> <input type="checkbox" > Amino acid metabolism </span> <ul> <li class="classification class-C "> <span> <input type="checkbox" > Serine and threonine metabolism </span> <ul> <li class="entry class-D module complete"> <span> <input type="checkbox" > <a href="/module/M00020" data-entry="M00020" target="_blank" >M00020</a> Serine biosynthesis </span> </li> </ul> </li> </ul> </li> </ul> </li> </ul> </div> </div> </div> </div> <button class="close"> <img src="/Fig/left_triangle_12x12.png"> </button> <button class="open"> <img src="/Fig/right_triangle_12x12.png"> </button> </div>  <form id="downloadForm" action="/kegg-bin/download" method="post"> <input type="hidden" name="name" value="map00680.png" /> <input type="hidden" name="content" /> <input type="hidden" name="dpi" /> <input type="hidden" name="decode" value="base64" /> </form> <div id="waiting-circle"> <img src="/Fig/waiting-circle-small.gif"> </div>  <form class="imageset" data-name=""> <input type="hidden" name="image_normal" value="/kegg/pathway/map/map00680.png 1x" data-src="/kegg/pathway/map/map00680.png" data-situation="1x"> <input type="hidden" name="image_grayscale" value="/kegg/pathway/map/map00680.png 1x" data-src="/kegg/pathway/map/map00680.png" data-situation="1x"> <input type="hidden" name="image_grayscale" value="/kegg/pathway/map/map00680@2x.png 2x" data-src="/kegg/pathway/map/map00680@2x.png" data-situation="2x"> </form>  <div id="download-menu" style="display:none;"> <div><a class="downloadImageNx" data-scale="1" href="#downloadImage1x">Image (png) file 1x</a></div> <div><a class="downloadImageNx" data-scale="2" href="#downloadImage2x">Image (png) file 2x</a></div> </div> </body> </html>