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searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">ANXA2</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_ANXA2_PDB_1w7b.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/09/Protein_ANXA2_PDB_1w7b.png/250px-Protein_ANXA2_PDB_1w7b.png" decoding="async" width="250" height="163" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/09/Protein_ANXA2_PDB_1w7b.png/375px-Protein_ANXA2_PDB_1w7b.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/09/Protein_ANXA2_PDB_1w7b.png/500px-Protein_ANXA2_PDB_1w7b.png 2x" data-file-width="1064" data-file-height="692" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P07356%20or%20P07355%20or%20H0YLE2">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P07356,P07355,H0YLE2">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1W7B">1W7B</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1XJL">1XJL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2HYU">2HYU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2HYV">2HYV</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2HYW">2HYW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4DRW">4DRW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4FTG">4FTG</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4HRH">4HRH</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/537">ANXA2</a></span>, ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV, annexin A2</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/151740">151740</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:88246">88246</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=20857">20857</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=ANXA2">ANXA2</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000182718">ANXA2 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_15.svg" class="mw-file-description" title="Chromosome 15 (human)"><img alt="Chromosome 15 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/07/Ideogram_human_chromosome_15.svg/300px-Ideogram_human_chromosome_15.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/07/Ideogram_human_chromosome_15.svg/450px-Ideogram_human_chromosome_15.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/07/Ideogram_human_chromosome_15.svg/600px-Ideogram_human_chromosome_15.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_15_(human)" class="mw-redirect" title="Chromosome 15 (human)">Chromosome 15 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_15_ideogram.svg" class="mw-file-description" title="Chromosome 15 (human)"><img alt="Chromosome 15 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Human_chromosome_15_ideogram.svg/300px-Human_chromosome_15_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Human_chromosome_15_ideogram.svg/450px-Human_chromosome_15_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Human_chromosome_15_ideogram.svg/600px-Human_chromosome_15_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 168.71596652856px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ANXA2"><img alt="Genomic location for ANXA2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 174.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ANXA2"><img alt="Genomic location for ANXA2" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">15q22.2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">60,347,134 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">60,402,883 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_9.svg" class="mw-file-description" title="Chromosome 9 (mouse)"><img alt="Chromosome 9 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/260px-Ideogram_house_mouse_chromosome_9.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/390px-Ideogram_house_mouse_chromosome_9.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/520px-Ideogram_house_mouse_chromosome_9.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 9 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_9.svg" class="mw-file-description" title="Chromosome 9 (mouse)"><img alt="Chromosome 9 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/300px-Ideogram_of_house_mouse_chromosome_9.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/450px-Ideogram_of_house_mouse_chromosome_9.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/600px-Ideogram_of_house_mouse_chromosome_9.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 158.38618974373px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ANXA2"><img alt="Genomic location for ANXA2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 164.4px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ANXA2"><img alt="Genomic location for ANXA2" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">9 C|9 38.58 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">69,360,902 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">69,399,077 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000182718">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">bronchial epithelial cell</li><br /><li style="line-height: 137%;">amniotic fluid</li><br /><li style="line-height: 137%;">nasal epithelium</li><br /><li style="line-height: 137%;">epithelium of nasopharynx</li><br /><li style="line-height: 137%;">synovial joint</li><br /><li style="line-height: 137%;">mucosa of pharynx</li><br /><li style="line-height: 137%;">visceral pleura</li><br /><li style="line-height: 137%;">parietal pleura</li><br /><li style="line-height: 137%;">oral cavity</li><br /><li style="line-height: 137%;">hair follicle</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000032231">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">corneal stroma</li><br /><li style="line-height: 137%;">endothelial cell of lymphatic vessel</li><br /><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">gastrula</li><br /><li style="line-height: 137%;">calvaria</li><br /><li style="line-height: 137%;">skin of external ear</li><br /><li style="line-height: 137%;">dermis</li><br /><li style="line-height: 137%;">umbilical cord</li><br /><li style="line-height: 137%;">conjunctival fornix</li><br /><li style="line-height: 137%;">right lung lobe</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000182718">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_ANXA2_210427_x_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/36/PBB_GE_ANXA2_210427_x_at_fs.png/250px-PBB_GE_ANXA2_210427_x_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/36/PBB_GE_ANXA2_210427_x_at_fs.png/375px-PBB_GE_ANXA2_210427_x_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/36/PBB_GE_ANXA2_210427_x_at_fs.png/500px-PBB_GE_ANXA2_210427_x_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_ANXA2_208816_x_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/PBB_GE_ANXA2_208816_x_at_fs.png/250px-PBB_GE_ANXA2_208816_x_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/PBB_GE_ANXA2_208816_x_at_fs.png/375px-PBB_GE_ANXA2_208816_x_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4e/PBB_GE_ANXA2_208816_x_at_fs.png/500px-PBB_GE_ANXA2_208816_x_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_ANXA2_201590_x_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/25/PBB_GE_ANXA2_201590_x_at_fs.png/250px-PBB_GE_ANXA2_201590_x_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/25/PBB_GE_ANXA2_201590_x_at_fs.png/375px-PBB_GE_ANXA2_201590_x_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/25/PBB_GE_ANXA2_201590_x_at_fs.png/500px-PBB_GE_ANXA2_201590_x_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/302/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004859">phospholipase inhibitor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005509">calcium ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044548">S100 protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019834">phospholipase A2 inhibitor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048306">calcium-dependent protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002020">protease binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008092">cytoskeletal protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005544">calcium-dependent phospholipid binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005546">phosphatidylinositol-4,5-bisphosphate binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098641">cadherin binding involved in cell-cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003723">RNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042802">identical protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044730">bone sialoprotein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098772">molecular function regulator</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001786">phosphatidylserine binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005262">calcium channel activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046790">virion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0099511">voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031982">vesicle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005768">endosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031902">late endosome membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042470">melanosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001726">ruffle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005811">lipid droplet</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035749">myelin sheath adaxonal region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043220">Schmidt-Lanterman incisure</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1990667">PCSK9-AnxA2 complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044354">macropinosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005604">basement membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009986">cell surface</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005765">lysosomal membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016323">basolateral plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005938">cell cortex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030496">midbody</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005769">early endosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048471">perinuclear region of cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042383">sarcolemma</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019897">extrinsic component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070062">extracellular exosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">extracellular space</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035578">azurophil granule lumen</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045121">membrane raft</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031012">extracellular matrix</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032991">protein-containing complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0062023">collagen-containing extracellular matrix</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032804">negative regulation of low-density lipoprotein particle receptor catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001934">positive regulation of protein phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051290">protein heterotetramerization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042730">fibrinolysis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007589">body fluid secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030199">collagen fibril organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048146">positive regulation of fibroblast proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0097066">response to thyroid hormone</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051099">positive regulation of binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031340">positive regulation of vesicle fusion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001765">membrane raft assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001525">angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006900">vesicle budding from membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0036035">osteoclast development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098609">cell-cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043086">negative regulation of catalytic activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001921">positive regulation of receptor recycling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043312">neutrophil degranulation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1905581">positive regulation of low-density lipoprotein particle clearance</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1905597">positive regulation of low-density lipoprotein particle receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1905599">positive regulation of low-density lipoprotein receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1905602">positive regulation of receptor-mediated endocytosis involved in cholesterol transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044147">negative regulation of formation of structure involved in a symbiotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044090">positive regulation of vacuole organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035722">interleukin-12-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072659">protein localization to plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003417">growth plate cartilage development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010755">regulation of plasminogen activation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031214">biomineral tissue development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032332">positive regulation of chondrocyte differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044794">positive regulation by host of viral process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051480">regulation of cytosolic calcium ion concentration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051928">positive regulation of calcium ion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060956">endocardial cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070588">calcium ion transmembrane transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1903902">positive regulation of viral life cycle</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=302&rn=1">302</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=12306&rn=1">12306</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000182718;db=core">ENSG00000182718</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000032231;db=core">ENSMUSG00000032231</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P07355">P07355</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P07356">P07356</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001002857">NM_001002857</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001002858">NM_001002858</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001136015">NM_001136015</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_004039">NM_004039</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007585">NM_007585</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001002857">NP_001002857</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001002858">NP_001002858</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001129487">NP_001129487</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_004030">NP_004030</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_031611">NP_031611</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr15:60347134-60402883">Chr 15: 60.35 – 60.4 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr9:69360902-69399077">Chr 9: 69.36 – 69.4 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14908233" class="extiw" title="d:Q14908233">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14908234" class="extiw" title="d:Q14908234">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Annexin A2</b> also known as <b>annexin II</b> is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>ANXA2</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid7961821_5-0" class="reference"><a href="#cite_note-pmid7961821-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>Annexin 2 is involved in diverse cellular processes such as <a href="/wiki/Cell_motility" class="mw-redirect" title="Cell motility">cell motility</a> (especially that of the <a href="/wiki/Epithelial_cells" class="mw-redirect" title="Epithelial cells">epithelial cells</a>), linkage of membrane-associated protein complexes to the actin <a href="/wiki/Cytoskeleton" title="Cytoskeleton">cytoskeleton</a>, <a href="/wiki/Endocytosis" title="Endocytosis">endocytosis</a>, fibrinolysis, <a href="/wiki/Ion_channel" title="Ion channel">ion channel</a> formation, and <a href="/wiki/Cell_junction" title="Cell junction">cell matrix</a> interactions. It is a calcium-dependent phospholipid-binding protein whose function is to help organize <a href="/wiki/Exocytosis" title="Exocytosis">exocytosis</a> of intracellular proteins to the extracellular domain. Annexin II is a <a href="/wiki/Pleiotropic" class="mw-redirect" title="Pleiotropic">pleiotropic</a> protein meaning that its function is dependent on place and time in the body. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Gene">Gene</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Annexin_A2&action=edit&section=1" title="Edit section: Gene"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <i>ANXA2</i> gene, located at 15q22.2, has three <a href="/wiki/Pseudogene" title="Pseudogene">pseudogenes</a> located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.<sup id="cite_ref-entrez_6-0" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Annexin_A2&action=edit&section=2" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>This protein is a member of the <a href="/wiki/Annexin" title="Annexin">annexin</a> family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption.<sup id="cite_ref-entrez_6-1" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Epigenetic regulation of Annexin A2 has been identified as a key determinant of mesenchymal transformation in brain tumors.<sup id="cite_ref-pmidTBD_7-0" class="reference"><a href="#cite_note-pmidTBD-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Maternal deficiency of the ANXA2 gene contributes to shallow decidual invasion by placental cytotrophoblast cells. These findings highlight the maternal contribution to the pathogenesis of severe <a href="/wiki/Pre-eclampsia" title="Pre-eclampsia">preeclampsia</a>.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>Annexin A2 has been proposed to function inside the cell in sorting of <a href="/wiki/Endosomes" class="mw-redirect" title="Endosomes">endosomes</a> and outside the cell in <a href="/wiki/Anticoagulant" title="Anticoagulant">anticoagulant</a> reactions. </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Annexin_A2&action=edit&section=3" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Annexin A2 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with <a href="/wiki/Prohibitin" title="Prohibitin">Prohibitin</a>,<sup id="cite_ref-pmid12628297_9-0" class="reference"><a href="#cite_note-pmid12628297-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> <a href="/wiki/CEACAM1" title="CEACAM1">CEACAM1</a>,<sup id="cite_ref-pmid14522961_10-0" class="reference"><a href="#cite_note-pmid14522961-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> <a href="/wiki/S100A10" title="S100A10">S100A10</a>,<sup id="cite_ref-pmid9886297_11-0" class="reference"><a href="#cite_note-pmid9886297-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid18434302_12-0" class="reference"><a href="#cite_note-pmid18434302-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> <a href="/wiki/PCNA" class="mw-redirect" title="PCNA">PCNA</a>,<sup id="cite_ref-pmid12171929_13-0" class="reference"><a href="#cite_note-pmid12171929-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> complement <a href="/wiki/Factor_H" title="Factor H">Factor H</a>,<sup id="cite_ref-pmid19951950_14-0" class="reference"><a href="#cite_note-pmid19951950-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> and a number of viral factors including the <a href="/wiki/HPV16" class="mw-redirect" title="HPV16">HPV16</a> minor <a href="/wiki/Papillomaviridae#L2" title="Papillomaviridae">capsid protein L2</a>.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Annexin_A2&action=edit&section=4" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Annexin" title="Annexin">Annexin</a></li></ul> <div style="clear:both;" class=""></div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Annexin_A2&action=edit&section=5" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000182718">GRCh38: Ensembl release 89: ENSG00000182718</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000032231">GRCm38: Ensembl release 89: ENSMUSG00000032231</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome 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Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein"</a>. <i>The Journal of Biological Chemistry</i>. <b>277</b> (43): 40362–40367. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M206194200">10.1074/jbc.M206194200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12171929">12171929</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=A+proteomics+approach+to+identify+proliferating+cell+nuclear+antigen+%28PCNA%29-binding+proteins+in+human+cell+lysates.+Identification+of+the+human+CHL12%2FRFCs2-5+complex+as+a+novel+PCNA-binding+protein&rft.volume=277&rft.issue=43&rft.pages=40362-40367&rft.date=2002-10&rft_id=info%3Adoi%2F10.1074%2Fjbc.M206194200&rft_id=info%3Apmid%2F12171929&rft.aulast=Ohta&rft.aufirst=S&rft.au=Shiomi%2C+Y&rft.au=Sugimoto%2C+K&rft.au=Obuse%2C+C&rft.au=Tsurimoto%2C+T&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M206194200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnnexin+A2" class="Z3988"></span></span> </li> <li id="cite_note-pmid19951950-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid19951950_14-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLefflerHerbertNorströmSchmidt2010" class="citation journal cs1">Leffler J, Herbert AP, Norström E, Schmidt CQ, Barlow PN, Blom AM, Martin M (February 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823518">"Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells"</a>. <i>The Journal of Biological Chemistry</i>. <b>285</b> (6): 3766–3776. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M109.045427">10.1074/jbc.M109.045427</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823518">2823518</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19951950">19951950</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Annexin-II%2C+DNA%2C+and+histones+serve+as+factor+H+ligands+on+the+surface+of+apoptotic+cells&rft.volume=285&rft.issue=6&rft.pages=3766-3776&rft.date=2010-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2823518%23id-name%3DPMC&rft_id=info%3Apmid%2F19951950&rft_id=info%3Adoi%2F10.1074%2Fjbc.M109.045427&rft.aulast=Leffler&rft.aufirst=J&rft.au=Herbert%2C+AP&rft.au=Norstr%C3%B6m%2C+E&rft.au=Schmidt%2C+CQ&rft.au=Barlow%2C+PN&rft.au=Blom%2C+AM&rft.au=Martin%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2823518&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnnexin+A2" class="Z3988"></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWoodhamDa_SilvaSkeateRaff2012" class="citation journal cs1">Woodham AW, Da Silva DM, Skeate JG, Raff AB, Ambroso MR, Brand HE, et al. (2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425544">"The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection"</a>. <i>PLOS ONE</i>. <b>7</b> (8): e43519. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2012PLoSO...743519W">2012PLoSO...743519W</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.pone.0043519">10.1371/journal.pone.0043519</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425544">3425544</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22927980">22927980</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=PLOS+ONE&rft.atitle=The+S100A10+subunit+of+the+annexin+A2+heterotetramer+facilitates+L2-mediated+human+papillomavirus+infection&rft.volume=7&rft.issue=8&rft.pages=e43519&rft.date=2012&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3425544%23id-name%3DPMC&rft_id=info%3Apmid%2F22927980&rft_id=info%3Adoi%2F10.1371%2Fjournal.pone.0043519&rft_id=info%3Abibcode%2F2012PLoSO...743519W&rft.aulast=Woodham&rft.aufirst=AW&rft.au=Da+Silva%2C+DM&rft.au=Skeate%2C+JG&rft.au=Raff%2C+AB&rft.au=Ambroso%2C+MR&rft.au=Brand%2C+HE&rft.au=Isas%2C+JM&rft.au=Langen%2C+R&rft.au=Kast%2C+WM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3425544&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnnexin+A2" class="Z3988"></span></span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWoodhamRaffRaffDa_Silva2014" class="citation journal cs1">Woodham AW, Raff AB, Raff LM, Da Silva DM, Yan L, Skeate JG, et al. (May 2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019435">"Inhibition of Langerhans cell maturation by human papillomavirus type 16: a novel role for the annexin A2 heterotetramer in immune suppression"</a>. <i>Journal of Immunology</i>. <b>192</b> (10): 4748–4757. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4049%2Fjimmunol.1303190">10.4049/jimmunol.1303190</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019435">4019435</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24719459">24719459</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Inhibition+of+Langerhans+cell+maturation+by+human+papillomavirus+type+16%3A+a+novel+role+for+the+annexin+A2+heterotetramer+in+immune+suppression&rft.volume=192&rft.issue=10&rft.pages=4748-4757&rft.date=2014-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4019435%23id-name%3DPMC&rft_id=info%3Apmid%2F24719459&rft_id=info%3Adoi%2F10.4049%2Fjimmunol.1303190&rft.aulast=Woodham&rft.aufirst=AW&rft.au=Raff%2C+AB&rft.au=Raff%2C+LM&rft.au=Da+Silva%2C+DM&rft.au=Yan%2C+L&rft.au=Skeate%2C+JG&rft.au=Wong%2C+MK&rft.au=Lin%2C+YG&rft.au=Kast%2C+WM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4019435&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnnexin+A2" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Annexin_A2&action=edit&section=6" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKwonMacLeodZhangWaisman2005" class="citation journal cs1">Kwon M, MacLeod TJ, Zhang Y, Waisman DM (January 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.2741%2F1529">"S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors"</a>. <i>Frontiers in Bioscience</i>. <b>10</b> (1–3): 300–325. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.2741%2F1529">10.2741/1529</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15574370">15574370</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Frontiers+in+Bioscience&rft.atitle=S100A10%2C+annexin+A2%2C+and+annexin+a2+heterotetramer+as+candidate+plasminogen+receptors&rft.volume=10&rft.issue=1%E2%80%933&rft.pages=300-325&rft.date=2005-01&rft_id=info%3Adoi%2F10.2741%2F1529&rft_id=info%3Apmid%2F15574370&rft.aulast=Kwon&rft.aufirst=M&rft.au=MacLeod%2C+TJ&rft.au=Zhang%2C+Y&rft.au=Waisman%2C+DM&rft_id=https%3A%2F%2Fdoi.org%2F10.2741%252F1529&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnnexin+A2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBabiychukDraeger2006" class="citation journal cs1">Babiychuk EB, Draeger A (June 2006). "Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement?". <i>Biochemical Society Transactions</i>. <b>34</b> (Pt 3): 374–376. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1042%2FBST0340374">10.1042/BST0340374</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16709165">16709165</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+Society+Transactions&rft.atitle=Regulation+of+ecto-5%27-nucleotidase+activity+via+Ca2%2B-dependent%2C+annexin+2-mediated+membrane+rearrangement%3F&rft.volume=34&rft.issue=Pt+3&rft.pages=374-376&rft.date=2006-06&rft_id=info%3Adoi%2F10.1042%2FBST0340374&rft_id=info%3Apmid%2F16709165&rft.aulast=Babiychuk&rft.aufirst=EB&rft.au=Draeger%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnnexin+A2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBohnGerkeKresseLöffler1992" class="citation journal cs1">Bohn E, Gerke V, Kresse H, Löffler BM, Kunze H (January 1992). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0014-5793%2892%2980294-Q">"Annexin II inhibits calcium-dependent phospholipase A1 and lysophospholipase but not triacyl glycerol lipase activities of rat liver hepatic lipase"</a>. <i>FEBS Letters</i>. <b>296</b> (3): 237–240. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0014-5793%2892%2980294-Q">10.1016/0014-5793(92)80294-Q</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1531641">1531641</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:19633878">19633878</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Annexin+II+inhibits+calcium-dependent+phospholipase+A1+and+lysophospholipase+but+not+triacyl+glycerol+lipase+activities+of+rat+liver+hepatic+lipase&rft.volume=296&rft.issue=3&rft.pages=237-240&rft.date=1992-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A19633878%23id-name%3DS2CID&rft_id=info%3Apmid%2F1531641&rft_id=info%3Adoi%2F10.1016%2F0014-5793%2892%2980294-Q&rft.aulast=Bohn&rft.aufirst=E&rft.au=Gerke%2C+V&rft.au=Kresse%2C+H&rft.au=L%C3%B6ffler%2C+BM&rft.au=Kunze%2C+H&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252F0014-5793%252892%252980294-Q&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnnexin+A2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDawsonWhite1992" class="citation journal cs1">Dawson SJ, White LA (May 1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". <i>The Journal of Infection</i>. <b>24</b> (3): 317–320. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0163-4453%2805%2980037-4">10.1016/S0163-4453(05)80037-4</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1602151">1602151</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Infection&rft.atitle=Treatment+of+Haemophilus+aphrophilus+endocarditis+with+ciprofloxacin&rft.volume=24&rft.issue=3&rft.pages=317-320&rft.date=1992-05&rft_id=info%3Adoi%2F10.1016%2FS0163-4453%2805%2980037-4&rft_id=info%3Apmid%2F1602151&rft.aulast=Dawson&rft.aufirst=SJ&rft.au=White%2C+LA&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnnexin+A2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJindalChaneyAndersonDavis1991" class="citation journal cs1">Jindal HK, Chaney WG, Anderson CW, Davis RG, Vishwanatha JK (March 1991). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2819%2967770-7">"The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha"</a>. <i>The Journal of Biological Chemistry</i>. <b>266</b> (8): 5169–5176. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2819%2967770-7">10.1016/S0021-9258(19)67770-7</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1825830">1825830</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=The+protein-tyrosine+kinase+substrate%2C+calpactin+I+heavy+chain+%28p36%29%2C+is+part+of+the+primer+recognition+protein+complex+that+interacts+with+DNA+polymerase+alpha&rft.volume=266&rft.issue=8&rft.pages=5169-5176&rft.date=1991-03&rft_id=info%3Adoi%2F10.1016%2FS0021-9258%2819%2967770-7&rft_id=info%3Apmid%2F1825830&rft.aulast=Jindal&rft.aufirst=HK&rft.au=Chaney%2C+WG&rft.au=Anderson%2C+CW&rft.au=Davis%2C+RG&rft.au=Vishwanatha%2C+JK&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0021-9258%252819%252967770-7&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnnexin+A2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFilipekGerkeWeberKuźnicki1991" class="citation journal cs1">Filipek A, Gerke V, Weber K, Kuźnicki J (February 1991). <a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1432-1033.1991.tb15768.x">"Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Oligo-capping%3A+a+simple+method+to+replace+the+cap+structure+of+eukaryotic+mRNAs+with+oligoribonucleotides&rft.volume=138&rft.issue=1%E2%80%932&rft.pages=171-174&rft.date=1994-01&rft_id=info%3Adoi%2F10.1016%2F0378-1119%2894%2990802-8&rft_id=info%3Apmid%2F8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnnexin+A2" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Annexin_A2&action=edit&section=7" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Annexin+A2">Annexin+A2</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=ANXA2"><i>ANXA2</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=ANXA2"><i>ANXA2</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline 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PROTEIN."><img alt="1w7b: ANNEXIN A2: DOES IT INDUCE MEMBRANE AGGREGATION BY A NEW MULTIMERIC STATE OF THE PROTEIN." src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7b/PDB_1w7b_EBI.jpg/180px-PDB_1w7b_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7b/PDB_1w7b_EBI.jpg/270px-PDB_1w7b_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7b/PDB_1w7b_EBI.jpg/360px-PDB_1w7b_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1w7b</b>: ANNEXIN A2: DOES IT INDUCE MEMBRANE AGGREGATION BY A NEW MULTIMERIC STATE OF THE PROTEIN.</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1xjl_EBI.jpg" class="mw-file-description" title="1xjl: Structure of human annexin A2 in the presence of calcium ions"><img alt="1xjl: Structure of human annexin A2 in the presence of calcium ions" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/af/PDB_1xjl_EBI.jpg/180px-PDB_1xjl_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/af/PDB_1xjl_EBI.jpg/270px-PDB_1xjl_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/af/PDB_1xjl_EBI.jpg/360px-PDB_1xjl_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1xjl</b>: Structure of human annexin A2 in the presence of calcium ions</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2hyu_EBI.png" class="mw-file-description" title="2hyu: Human Annexin A2 with heparin tetrasaccharide bound"><img alt="2hyu: Human Annexin A2 with heparin tetrasaccharide bound" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5e/PDB_2hyu_EBI.png/180px-PDB_2hyu_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5e/PDB_2hyu_EBI.png/270px-PDB_2hyu_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5e/PDB_2hyu_EBI.png/360px-PDB_2hyu_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2hyu</b>: Human Annexin A2 with heparin tetrasaccharide bound</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2hyv_EBI.png" class="mw-file-description" title="2hyv: Human Annexin A2 with heparin hexasaccharide bound"><img alt="2hyv: Human Annexin A2 with heparin hexasaccharide bound" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/PDB_2hyv_EBI.png/180px-PDB_2hyv_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/PDB_2hyv_EBI.png/270px-PDB_2hyv_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/00/PDB_2hyv_EBI.png/360px-PDB_2hyv_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2hyv</b>: Human Annexin A2 with heparin hexasaccharide bound</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2hyw_EBI.png" class="mw-file-description" title="2hyw: Human Annexin A2 with Calcium bound"><img alt="2hyw: Human Annexin A2 with Calcium bound" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0a/PDB_2hyw_EBI.png/180px-PDB_2hyw_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0a/PDB_2hyw_EBI.png/270px-PDB_2hyw_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0a/PDB_2hyw_EBI.png/360px-PDB_2hyw_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2hyw</b>: Human Annexin A2 with Calcium bound</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Cell_signaling:_calcium_signaling_and_calcium_metabolism" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Calcium_signaling" title="Template:Calcium signaling"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Calcium_signaling" title="Template talk:Calcium signaling"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Calcium_signaling" title="Special:EditPage/Template:Calcium signaling"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cell_signaling:_calcium_signaling_and_calcium_metabolism" style="font-size:114%;margin:0 4em"><a href="/wiki/Cell_signaling" title="Cell signaling">Cell signaling</a>: <a href="/wiki/Calcium_signaling" title="Calcium signaling">calcium signaling</a> and <a href="/wiki/Calcium_metabolism" title="Calcium metabolism">calcium metabolism</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_membrane" title="Cell membrane">Cell membrane</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Adhesion_molecules" class="mw-redirect" title="Adhesion molecules">Adhesion molecules</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cadherin" title="Cadherin">Cadherins</a> <ul><li><a href="/wiki/CDH1_(gene)" class="mw-redirect" title="CDH1 (gene)">CDH1</a></li> <li><a href="/wiki/CDH2" class="mw-redirect" title="CDH2">CDH2</a></li> <li><a href="/wiki/CDH3_(gene)" title="CDH3 (gene)">CDH3</a></li> <li><a href="/wiki/CDH4" title="CDH4">CDH4</a></li> <li><a href="/wiki/CDH5" class="mw-redirect" title="CDH5">CDH5</a></li> <li><a href="/wiki/CDH6" title="CDH6">CDH6</a></li> <li><a href="/w/index.php?title=CDH7&action=edit&redlink=1" class="new" title="CDH7 (page does not exist)">CDH7</a></li> <li><a href="/wiki/CDH8" title="CDH8">CDH8</a></li> <li><a href="/wiki/CDH9" title="CDH9">CDH9</a></li> <li><a href="/wiki/CDH10" title="CDH10">CDH10</a></li> <li><a href="/wiki/CDH11" title="CDH11">CDH11</a></li> <li><a href="/wiki/CDH12" title="CDH12">CDH12</a></li> <li><a href="/wiki/CDH13" class="mw-redirect" title="CDH13">CDH13</a></li> <li><a href="/w/index.php?title=CDH14&action=edit&redlink=1" class="new" title="CDH14 (page does not exist)">CDH14</a></li> <li><a href="/wiki/CDH15" title="CDH15">CDH15</a></li> <li><a href="/wiki/CDH16" title="CDH16">CDH16</a></li> <li><a href="/wiki/CDH17" title="CDH17">CDH17</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Calcium_channel" title="Calcium channel">Calcium channels</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ligand-gated_ion_channel" title="Ligand-gated ion channel">Ligand-gated</a> <ul><li><a href="/wiki/5-HT3_receptor" title="5-HT3 receptor">5-HT3 receptor</a></li> <li><a href="/wiki/Ionotropic_glutamate_receptor" title="Ionotropic glutamate receptor">Ionotropic glutamate receptors</a> <ul><li><a href="/wiki/AMPA_receptor" title="AMPA receptor">AMPA receptors</a></li> <li><a href="/wiki/Kainate_receptor" title="Kainate receptor">Kainate receptors</a></li> <li><a href="/wiki/NMDA_receptor" title="NMDA receptor">NMDA receptors</a></li></ul></li> <li><a href="/wiki/P2X_purinoreceptor" title="P2X purinoreceptor">P2X receptors</a></li></ul></li> <li><a href="/wiki/Voltage-gated_calcium_channel" title="Voltage-gated calcium channel">Voltage-gated</a> <ul><li><a href="/wiki/L-type_calcium_channel" title="L-type calcium channel">L</a></li> <li><a href="/wiki/N-type_calcium_channel" title="N-type calcium channel">N</a></li> <li><a href="/wiki/P-type_calcium_channel" title="P-type calcium channel">P</a></li> <li><a href="/wiki/R-type_calcium_channel" title="R-type calcium channel">R</a></li> <li><a href="/wiki/T-type_calcium_channel" title="T-type calcium channel">T</a></li></ul></li> <li><a href="/wiki/Transient_receptor_potential_channel" title="Transient receptor potential channel">TRP channels</a> <ul><li><a href="/wiki/TRPA_(ion_channel)" title="TRPA (ion channel)">TRPA</a></li> <li><a href="/wiki/TRPC" title="TRPC">TRPC</a></li> <li><a href="/wiki/TRPV" title="TRPV">TRPV</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ion_transporter" title="Ion transporter">Calcium pumps</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium-calcium_exchanger" title="Sodium-calcium exchanger">Sodium-calcium exchangers</a> <ul><li><a href="/wiki/SLC3A2" class="mw-redirect" title="SLC3A2">SLC3A2</a></li> <li><a href="/wiki/SLC8A1" class="mw-redirect" title="SLC8A1">SLC8A1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/GPCR" class="mw-redirect" title="GPCR">GPCRs</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcium-sensing_receptor" title="Calcium-sensing receptor">Calcium-sensing receptor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Annexin" title="Annexin">Annexins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Annexin_A1" title="Annexin A1">A1</a></li> <li><a class="mw-selflink selflink">A2</a></li> <li><a href="/wiki/Annexin_A3" title="Annexin A3">A3</a></li> <li><a href="/wiki/Annexin_A4" title="Annexin A4">A4</a></li> <li><a href="/wiki/Annexin_A5" title="Annexin A5">A5</a></li> <li><a href="/wiki/Annexin_A6" title="Annexin A6">A6</a></li> <li><a href="/wiki/Annexin_A7" title="Annexin A7">A7</a></li> <li><a href="/w/index.php?title=Annexin_A8&action=edit&redlink=1" class="new" title="Annexin A8 (page does not exist)">A8</a></li> <li><a href="/wiki/ANXA8L2" title="ANXA8L2">A8-L2</a></li> <li><a href="/wiki/Annexin_A9" title="Annexin A9">A9</a></li> <li><a href="/w/index.php?title=Annexin_A10&action=edit&redlink=1" class="new" title="Annexin A10 (page does not exist)">A10</a></li> <li><a href="/wiki/Annexin_A11" title="Annexin A11">A11</a></li> <li><a href="/w/index.php?title=Annexin_A12&action=edit&redlink=1" class="new" title="Annexin A12 (page does not exist)">A12</a></li> <li><a href="/wiki/Annexin_A13" title="Annexin A13">A13</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Intracellular <a href="/wiki/Signal_transduction" title="Signal transduction">signaling</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Second_messengers" class="mw-redirect" title="Second messengers">Second messengers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Inositol_triphosphate" class="mw-redirect" title="Inositol triphosphate">IP3</a></li> <li><a href="/wiki/Nicotinic_acid_adenine_dinucleotide_phosphate" title="Nicotinic acid adenine dinucleotide phosphate">NAADP</a></li> <li><a href="/wiki/Cyclic_ADP-ribose" title="Cyclic ADP-ribose">cADPR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ryanodine-Inositol_1,4,5-triphosphate_receptor_calcium_channels" title="Ryanodine-Inositol 1,4,5-triphosphate receptor calcium channels">Intracellular channels</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Inositol_trisphosphate_receptor" title="Inositol trisphosphate receptor">IP3 receptor</a></li> <li><a href="/wiki/Ryanodine_receptor" title="Ryanodine receptor">Ryanodine receptor</a> <ul><li><a href="/wiki/Calcium-induced_calcium_release" title="Calcium-induced calcium release">Calcium-induced calcium release</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Intracellular pumps</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/SERCA" title="SERCA">SERCA</a> <ul><li><a href="/wiki/ATP2A1" title="ATP2A1">ATP2A1</a></li> <li><a href="/wiki/ATP2A2" title="ATP2A2">ATP2A2</a></li> <li><a href="/wiki/ATP2A3" title="ATP2A3">ATP2A3</a></li></ul></li> <li><a href="/wiki/Sodium-calcium_exchanger" title="Sodium-calcium exchanger">Sodium-calcium exchangers</a> <ul><li><a href="/wiki/SLC8B1" title="SLC8B1">SLC8B1</a></li> <li><a href="/wiki/SLC24A5" class="mw-redirect" title="SLC24A5">SLC24A5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Intracellular_calcium-sensing_proteins" title="Intracellular calcium-sensing proteins">Sensors</a> and <a href="/wiki/Chelator" class="mw-redirect" title="Chelator">chelators</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calbindin" title="Calbindin">Calbindin</a></li> <li><a href="/wiki/Calmodulin" title="Calmodulin">Calmodulin</a> <ul><li><a href="/wiki/CALM1" class="mw-redirect" title="CALM1">CALM1</a></li> <li><a href="/wiki/CALM2" title="CALM2">CALM2</a></li> <li><a href="/wiki/CALM3" title="CALM3">CALM3</a></li> <li><a href="/wiki/CALML3" title="CALML3">CALML3</a></li> <li><a href="/wiki/CALML5" title="CALML5">CALML5</a></li></ul></li> <li><a href="/wiki/Calsequestrin" title="Calsequestrin">Calsequestrin</a></li> <li><a href="/wiki/Calretinin" title="Calretinin">Calretinin</a></li> <li><a href="/wiki/Gelsolin" title="Gelsolin">Gelsolin</a></li> <li><a href="/wiki/Neuronal_calcium_sensor" title="Neuronal calcium sensor">Neuronal calcium sensors</a> <ul><li><a href="/wiki/Calsenilin" title="Calsenilin">Calsenilin</a></li> <li><a href="/wiki/Frequenin" class="mw-redirect" title="Frequenin">Frequenin</a></li> <li><a href="/wiki/Guanylate_cyclase_activator" title="Guanylate cyclase activator">GUCA</a> <ul><li><a href="/wiki/GUCA1A" title="GUCA1A">1A</a></li> <li><a href="/wiki/GUCA1B" title="GUCA1B">1B</a></li></ul></li> <li><a href="/wiki/Hippocalcin" title="Hippocalcin">Hippocalcin</a></li> <li><a href="/wiki/Neurocalcin" title="Neurocalcin">Neurocalcin</a></li> <li><a href="/wiki/Recoverin" title="Recoverin">Recoverin</a></li> <li><a href="/wiki/VSNL1" class="mw-redirect" title="VSNL1">Visinin</a></li></ul></li> <li><a href="/wiki/Parvalbumin" title="Parvalbumin">Parvalbumin</a></li> <li><a href="/wiki/Phospholamban" title="Phospholamban">Phospholamban</a></li> <li><a href="/wiki/Sarcalumenin" title="Sarcalumenin">Sarcalumenin</a></li> <li><a href="/wiki/Synaptotagmin" title="Synaptotagmin">Synaptotagmins</a> <ul><li><a href="/wiki/SYT1" title="SYT1">SYT1</a></li> <li><a href="/wiki/SYT2" title="SYT2">SYT2</a></li> <li><a href="/wiki/SYT3" title="SYT3">SYT3</a></li> <li><a href="/wiki/SYT4" title="SYT4">SYT4</a></li> <li><a href="/wiki/SYT5" title="SYT5">SYT5</a></li> <li><a href="/wiki/SYT6" title="SYT6">SYT6</a></li> <li><a href="/wiki/SYT7" title="SYT7">SYT7</a></li> <li><a href="/wiki/SYT9" title="SYT9">SYT9</a></li> <li><a href="/wiki/SYT11" title="SYT11">SYT11</a></li> <li><a href="/wiki/SYT13" title="SYT13">SYT13</a></li> <li><a href="/wiki/SYT14" class="mw-redirect" title="SYT14">SYT14</a></li></ul></li> <li><a href="/wiki/S100_protein" title="S100 protein">S100</a></li> <li><a href="/wiki/S100P" title="S100P">S100P</a></li> <li><a href="/wiki/Troponin_C" title="Troponin C">Troponin C</a> <ul><li><a href="/wiki/TNNC1" class="mw-redirect" title="TNNC1">TNNC1</a></li> <li><a href="/wiki/TNNC2" class="mw-redirect" title="TNNC2">TNNC2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Calcium-dependent <a href="/wiki/Chaperone_(protein)" title="Chaperone (protein)">chaperones</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calreticulin" title="Calreticulin">Calreticulin</a></li> <li><a href="/wiki/Calnexin" title="Calnexin">Calnexin</a></li> <li><a href="/wiki/HSPA5" class="mw-redirect" title="HSPA5">HSPA5</a></li> <li><a href="/wiki/HSP90B1" title="HSP90B1">HSP90B1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Calcium-dependent <a href="/wiki/Kinase" title="Kinase">kinases</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calmodulin-dependent_kinase" class="mw-redirect" title="Calmodulin-dependent kinase">CaM kinases</a> <ul><li><a href="/wiki/CAMK1" title="CAMK1">CAMK1</a></li> <li><a href="/wiki/CAMKII" class="mw-redirect" title="CAMKII">CAMK2</a> <ul><li><a href="/wiki/CAMK2A" class="mw-redirect" title="CAMK2A">A</a></li> <li><a href="/wiki/CAMK2B" title="CAMK2B">B</a></li> <li><a href="/wiki/CAMK2D" title="CAMK2D">D</a></li> <li><a href="/wiki/CAMK2G" title="CAMK2G">G</a></li></ul></li> <li><a href="/wiki/EEF2K" title="EEF2K">CAMK3</a></li> <li><a href="/wiki/CAMK4" title="CAMK4">CAMK4</a></li></ul></li> <li><a href="/wiki/Protein_kinase_C" title="Protein kinase C">Protein kinase C</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Calcium-dependent <a href="/wiki/Protease" title="Protease">proteases</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calpain" title="Calpain">Calpains</a> <ul><li><a href="/wiki/CAPN1" class="mw-redirect" title="CAPN1">CAPN1</a></li> <li><a href="/wiki/CAPN2" class="mw-redirect" title="CAPN2">CAPN2</a></li> <li><a href="/wiki/CAPN3" class="mw-redirect" title="CAPN3">CAPN3</a></li> <li><a href="/wiki/CAPNS1" class="mw-redirect" title="CAPNS1">CAPN4</a></li> <li><a href="/wiki/CAPN5" title="CAPN5">CAPN5</a></li> <li><a href="/wiki/CAPN6" class="mw-redirect" title="CAPN6">CAPN6</a></li> <li><a href="/w/index.php?title=CAPN7&action=edit&redlink=1" class="new" title="CAPN7 (page does not exist)">CAPN7</a></li> <li><a href="/wiki/CAPN8" class="mw-redirect" title="CAPN8">CAPN8</a></li> <li><a href="/wiki/CAPN9" class="mw-redirect" title="CAPN9">CAPN9</a></li> <li><a href="/wiki/CAPN10" title="CAPN10">CAPN10</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Indirect regulators</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcitonin" title="Calcitonin">Calcitonin</a></li> <li><a href="/wiki/Parathyroid_hormone" title="Parathyroid hormone">Parathyroid hormone</a></li> <li><a href="/wiki/Vitamin_D" title="Vitamin D">Vitamin D</a></li> <li><a href="/wiki/Vitamin_K" title="Vitamin K">Vitamin K</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Extracellular <a href="/wiki/Chelation" title="Chelation">chelators</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Extracellular_matrix" title="Extracellular matrix">Extracellular matrix</a> proteins</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fibulin" title="Fibulin">Fibulins</a> <ul><li><a href="/wiki/FBLN1" title="FBLN1">FBLN1</a></li> <li><a href="/wiki/FBLN2" title="FBLN2">FBLN2</a></li> <li><a href="/wiki/FBLN3" class="mw-redirect" title="FBLN3">FBLN3</a></li> <li><a href="/wiki/FBLN4" class="mw-redirect" title="FBLN4">FBLN4</a></li> <li><a href="/wiki/FBLN5" title="FBLN5">FBLN5</a></li></ul></li> <li><a href="/wiki/Hemicentin_1" title="Hemicentin 1">Hemicentin 1</a></li> <li><a href="/wiki/Matrix_gla_protein" class="mw-redirect" title="Matrix gla protein">Matrix gla protein</a></li> <li><a href="/wiki/Osteonectin" title="Osteonectin">Osteonectin</a></li> <li><a href="/wiki/SIBLING_proteins" title="SIBLING proteins">SIBLINGs</a> <ul><li><a href="/wiki/Bone_sialoprotein" title="Bone sialoprotein">Bone sialoprotein</a></li> <li><a href="/wiki/DMP1" title="DMP1">Dentin matrix phosphoprotein</a></li> <li><a href="/wiki/Dentin_sialophosphoprotein" title="Dentin sialophosphoprotein">Dentin sialophosphoprotein</a></li> <li><a href="/wiki/Osteopontin" title="Osteopontin">Osteopontin</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hormone" title="Hormone">Secreted hormones</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Osteocalcin" title="Osteocalcin">Osteocalcin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Calcium-binding <a href="/wiki/Protein_domain" title="Protein domain">domains</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/C2_domain" title="C2 domain">C2 domain</a></li> <li><a href="/wiki/Cadherin" title="Cadherin">Cadherin</a></li> <li><a href="/wiki/C-type_lectin" title="C-type lectin">C-type lectin</a></li> <li><a href="/wiki/EF_hand" title="EF hand">EF hand</a></li> <li><a href="/wiki/EGF-like_domain" title="EGF-like domain">EGF-like domain</a></li> <li><a href="/wiki/Gla_domain" title="Gla domain">Gla domain</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1&useformat=desktop" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" 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