CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '9255f9504bb84095',cH: 'WN2iLR7G9vh110iFxtCTEaaWoFlyB.2jksGJOyzM1xA-1742817267-1.2.1.1-ESfqzE9Ir0ttYI1ofFJVdHzY8is4c39.BFcYF0lzvTETp0iXBvT7IUw2MX0G5Tfq',cUPMDTk: "\/doi\/abs\/10.1021\/jm00159a037?__cf_chl_tk=L4lXL3cjGCBR.3aU5g2zAMvrBLlF5wvEjis8VWrqwPY-1742817267-1.0.1.1-G2Uh1PQy7lGNmBeLHmxeQm9MlnCLnRWkpQ5chtmHsOI",cFPWv: 'b',cITimeS: '1742817267',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/abs\/10.1021\/jm00159a037?__cf_chl_f_tk=L4lXL3cjGCBR.3aU5g2zAMvrBLlF5wvEjis8VWrqwPY-1742817267-1.0.1.1-G2Uh1PQy7lGNmBeLHmxeQm9MlnCLnRWkpQ5chtmHsOI",md: "tsNx9GhFR7jjmVSQX5gC31bl2inRvRY.4S5_bI_yFV4-1742817267-1.2.1.1-Chss7ulgbqCIkNs3rJzTn9nspkcyUB53mzUwaF5lCbeWaIRolEJmfo33jgg1PbXx0lgWSCw4zv9HzV8rZNKcd6.ouRCS.iqaL_YLaDY35sVWm0PePccS2Q3IyefzpuZ_S7XX4McDAStvEQzf_lpkbuSZBkZCHXhe1wjEhtK2.wf929sY8QenVO76Qm_7NRrXz5LBdSe1Khgvjm1vrEdzObjVEdqi9AFZb91gUczFVMCoejoJ0VFhuAm8UFzGQenMXuiuAxFym7dWnsDI584tlu3bWQHJc3tgTBRmTnnsCzj3fCi1uxR3foQai_d8xzFULqQ92zabISEFYuV5Pwd8inSnEADKlz67n9.ickVFw8q__eqfACd9x.NyLbkzbyaF5wcim4_cQckwCTR.R84M4jVO6SBXcBtNZgE1hYX3OciQgx0xg0_jRApvw4583aR01IwvIBTSDGskCSlGmtOiDb899WcewICuFaZ5TG1JxyPG9c1xqRRIn6N_yxB61u38gDJRYvt3WY6Hgx9w1K_GrcDJ94lvOYKk.n.IaBYvfOSQgHl_FRjTCkbpgFa_wCYCIL217VzScoUl_2k7S.cVivExeSpqoD_kmn8kp.5cQOh3VwaByTxZZFGWx1bCBgTE81gqZYfrWL0B7Tky8lbx1PuVhmN7FGGDu3_ZenTzCDR1yl9QmpJ.h1Pb0YQ0v.yhkZjOjayL8i1a9rRLGTHUgPygW9MaXvLW1KMlAud2HfdC.AkPnLYA5cOZ30E5.wp5IKBPpS08B4USuYYv8LvwoX9qqsSHVLL6iFO0YJuG52aU1xKgMmENRYbagTuyxr6ibMCBuLp1tQHkPo1CUtmQ3dob34uvBZE53YdRnzsIx4yQu144LS3Lx91dA.vR1liPVaCZcr7S6FCbCMNNwCzRBc.GIT7sp3ZcCv8INVfjXxViKw39q_Tfw05nGsDGqAnFt3feUZPfb30B.nVAIZ9IGcwlsmKpRFU4tJXOGUIn8HO_khI4ujEmCxXfcevHLrXNIkvI2Ccls0h7JTNBNrJbDrwg8mkOebc7y18G3N3pxY1DAlDMX2wCJ.bXRGoloipclGsvYFu.MemFrURxpdMsqdGORvLlp.WU0YcH5pRt82bmRPOWFl_FyOCIk9eiXg.fpjmBW.xmVxCAZzkB9x6BVXzPZsviGChV8Zy99hGcqtfgvD12BEOfVMtpqk.jq8jbrtEsvPKRc.JODpKF.nh9OyGLHDYsVc5Hzy8tlSoa3XsnYYhJiWiRtox89nezC.WXgj0nI_IJ.CXU6Fxe_2YAIw",mdrd: "IXwqmHX2ZUT0.Sc3OCwyeHsqND5CNPOAtz44.Be2N6Q-1742817267-1.2.1.1-GCINrAJnvzeXTCWCQ7MX5QTaIqITIZoUXDKbbWa3RdxTJGRrKtuejqMclNoGeTEnvw8vkHIN00kbVf6l2nu.G41Y0lxkuiR8i4.KHBzs72tMSUi0Ht8AUDHOo2mQy2mI1Reu51H_EWUpoOFyABXVZNw3JdLz0SQoiGitSgdsjX1znBDCbL867qso68veci3oua.hxBBt8W4U1ocCp5wcAy1SRwvoeh.uPbcL0ba_GLyNcJ.iQdrBeL2hFYAST5QFxXsBp7htW7EQAsAtCXQ7fW5EkawFcaGqk.hdAzmgJzQaY.7cCsbstVMBXbNKtVtV3Kzsw5cxDgi_ci6aTUD57rDwcRMRH_Cxu0Jk9KUa_bm4Jtwkdtbzb90X8bDAtC7vDq1HEjoc6oGRlgdFQvYYy9cWvZUojT22CuGmIR7udB5237ctP_Bb1Tn9caXNAuJcmo1jAii1w9hbg1ftRajqfk26Gnk209cl1xceQ4Knie3bJuwuREjtAgJ_sjmgGOhr4Flj4RdvcQOefk0v3T.c765KLMLIKDN_GgPL4Es6vT9cSo6veYZ1jZ9nYxRvCsMcBMmGdRn6H_i0dj8AUBXs0Dd8I3eMU9l3l5Ocjj3tw0AVO_XPE1c1lOijnDsDwTIIcCmDFNBMlZ_BdxacljLcpRmOmaQtBz7qyQR70ScCMPNck5mYPNr5tjbYYIuCk4V.Uc5f87DNuEsu61WpEwHC_93cp0opKDH3nQ158kfnxsYVEYr2966AFa4yIhKHOk2zbucVGdTklkJmeUxDfjv.q_kUOZdKl3pucwuSpDS1nM8sYuP7FrfC1YgR8ulGOMxW186zwDzB8W9TN5BT2mq2ES.GlaW2UOuwKgPrteICIkaPbI6M6epacnv3a3Dl2U4myiWeRoNw5ymUb_vlipAhDLBAuLc8A6ulLGqyZM7tfm4WK5Yv5XT60UY1SqUItpx3aohh.6xHzdeSMegTydMbALKBg2Cg7J0KHMvJUALe6PbLk5NDAcA047ErUqs4D2XnEl0HUXZDkHaZDIzfU_.wiMHh.3z3h7k4GioqanJRlblEH4PA9G7YvzMVZMOnWbxDe5MgV1c20x9LQgYVgrlEt0JLsGwi6l6Rn_PROTiKMkWsGki8jqqxFwxa3_SVH1LNXL2o5fxp12vIBXKouexScpawEiWpGM86fch4o9PzBihmIBzQkLTJMrCSdPj2QS1j1DRu.JB66eAEdSaz.D4PJw1JnhYKIqTnVty0VQN7ZpfLQCfSI9ax90m1tC.pOe7x4JC7DVwjdREWKKbdh.je7TmMnhKrfSB0DJ1Qclx7_ni9avjmkpWjp726knLBjjmO_YwGXPH7DQkRW0s18rugthOy5I6yP4Z89wp1.FguqCpvH30PmlPvS.8TgbRrjjCveoc5zyWwQkmpjmsjq6B64ZJ4OlRKYFGITl9hjSV5LnDFVtvbWdGyenHEh38KPw10QoJVFXgY89vjfbdwthOyO8gFKouALznZ1iW_qUqJZo_c9bIzAtpgw.bYyvviyjNuP80szX6EXWNFRgyzPWn04Cw5mNawl.YP4sJxGUznLbB5pCd5z_foYhQUM8QQEnlGABohPDi9tqj4YKRTXdO9OzQa8hGl8WDZzBnnmCc7tO0Nq_r7KhwjrCaNwGe_Fdc0XSJhIoTbvokDDwaiNAWfP4x3.HVtU2HyB.AA5dwTlElg88WVt381iGX6yUYUmzA7WI7f5dFP_nZo1Oczun7_DF6EpjF54kqdOLlCvVaajwkkxdmsCo8fK2gia5QFgH7dwRX0dXwWtlGC35dWPoIccfrnFJs_cx36SBdUORlq13wkWRLYXVNY6RsefU2Bbrtm5jxh6mlTBnTE6u2LvTgFjk59.qAFMI7azRYt4N7kzG3CoigVePXocByL9j5k6SD_mFkfMWRgrt9CcF8J5ukVo0tkXfIz34Jdt9FKEIJl07OZ9MC5YJcGr7ZmQdCboeTAAiOMA2OjlZvcJHEWiEVhRuOWfCq07LhHRVXkzdthLY0WI79Q0VRcs6We62iEU9gAbyGcSTsNJUqS4M7dWiOwng"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=9255f9504bb84095';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/abs\/10.1021\/jm00159a037?__cf_chl_rt_tk=L4lXL3cjGCBR.3aU5g2zAMvrBLlF5wvEjis8VWrqwPY-1742817267-1.0.1.1-G2Uh1PQy7lGNmBeLHmxeQm9MlnCLnRWkpQ5chtmHsOI" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>