Meta-analysis compares safety profiles of ranibizumab intravitreal injections

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charset=utf-8"/><title> Meta-analysis compares safety profiles of ranibizumab intravitreal injections | Ophthalmology </title>  <meta name="google-site-verification" content="TCYGZWR7Qscjc3GO_imiutAfXMSCFLpchm8rXzIk-5M"/><meta name="msvalidate.01" content="AB0F11E889D663098DB556BB5ACBB719"/><meta id="metaDescription" name="description" content="Ophthalmology | TORONTO &mdash; Results of a meta-analysis comparing the safety profiles of intravitreal ranibizumab injections are consistent with the established systemic safety profile of ranibizumab, according to a presenter here. &ldquo;Intravitreally, there are concerns about the possibility of systemic adverse events, but we haven&rsquo;t really been able to calculate accurately because of sample "/><meta id="metaKeywords" name="keywords" content="Ophthalmology,Ophthalmology,Retina/Vitreous,Meeting News Coverage"/><meta id="Meta1" name="scID"/><meta id="scID" name="scID"/><meta name="PostedDate" content="2013-09-03"/> <meta name="specialties" content="Ophthalmology"/> <meta name="specialty" content="Ophthalmology"/> <meta name="primary_specialty" content="Ophthalmology"/> <meta name="subspecialties" content="Retina/Vitreous"/> <meta name="subspecialty" content="Retina/Vitreous"/> <meta name="primary_subspecialty" content="Retina/Vitreous"/> <meta name="departments" content="Meeting News Coverage"/> <meta name="department" content="Meeting News Coverage"/> <meta name="content_type" content="News Article"/> <meta name="pageid" content="{28147864-DA25-4993-9C8A-7DD05ABCC7A3}"/> <meta property="og:image" content="https://web.archive.org/web/20130906135223im_/http://213a1ca8842e5e699a80-05ce35571e92a3f7383a191aa5840bba.r66.cf1.rackcdn.com/healio_safe_image.png"/><meta name="authors" content=""/><meta name="articleid" content="{28147864-DA25-4993-9C8A-7DD05ABCC7A3}"/><meta name="legacyarticleid" content=""/><meta name="article-title" content="Meta-analysis compares safety profiles of ranibizumab intravitreal injections"/><meta name="article-link" content="/ophthalmology/retina-vitreous/news/online/{28147864-da25-4993-9c8a-7dd05abcc7a3}/meta-analysis-compares-safety-profiles-of-ranibizumab-intravitreal-injections"/><meta name="pubname" content="Ophthalmology"/><meta name="pubtype" content="online"/><meta name="issue-name" content="03"/><meta name="issue-year" content=""/><meta name="source" content=""/><meta name="author" content=""/>  <link href="https://web.archive.org/web/20130906135223cs_/http://c341130.r30.cf1.rackcdn.com/styles.css" rel="stylesheet" type="text/css"/>  <link href="https://web.archive.org/web/20130906135223cs_/http://c341130.r30.cf1.rackcdn.com/styles2.css" rel="stylesheet" type="text/css"/><link href="https://web.archive.org/web/20130906135223cs_/http://c341130.r30.cf1.rackcdn.com/tb-ec-lb-min.css" rel="stylesheet" type="text/css" media="screen"/><link href="https://web.archive.org/web/20130906135223cs_/http://0043b493b06d545127da-d7c71b4c9ba1dd44e0cf6fa474e637d7.r99.cf1.rackcdn.com/healiojobs.css" rel="stylesheet" type="text/css"/><link href="https://web.archive.org/web/20130906135223cs_/http://6af4390358a281e0b439-028b17272c3ee5c2953a93a8c54187e2.r22.cf1.rackcdn.com/MediaKits.css" rel="stylesheet" type="text/css"/>  <link rel="shortcut icon" type="image/x-icon" href="https://web.archive.org/web/20130906135223im_/http://213a1ca8842e5e699a80-05ce35571e92a3f7383a191aa5840bba.r66.cf1.rackcdn.com/favicon.ico"/> <style type="text/css"> #wrap:before, #wrap:after { content: " "; 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Q8WAh8DAgIWBAIBD2QWBmYPFQEFZmlyc3RkAgEPZBYCZg8VBANhbGwXL29waHRoYWxtb2xvZ3kvbWVldGluZ3MAEE1lZXRpbmdzL0NvdXJzZXNkAgMPFgIfAmgWAmYPFQEQTWVldGluZ3MvQ291cnNlc2QCAg9kFgZmDxUBBWZpcnN0ZAIBD2QWAmYPFQQDYWxsLS9vcGh0aGFsbW9sb2d5L21lZXRpbmdzL21lZXRpbmctbmV3cy1jb3ZlcmFnZQAVTWVldGluZyBOZXdzIENvdmVyYWdlZAIDDxYCHwJoFgJmDxUBFU1lZXRpbmcgTmV3cyBDb3ZlcmFnZWQCCA9kFgRmDxUEFi9vcGh0aGFsbW9sb2d5L2NhcmVlcnMHQ2FyZWVycwAHQ2FyZWVyc2QCAQ8WAh8DZmQCDw9kFgJmD2QWAmYPZBYGAgEPZBYCAgEPFgIfAwIEFghmD2QWAmYPFQIBLwZIZWFsaW9kAgIPZBYCZg8VAg4vb3BodGhhbG1vbG9neQ1PcGh0aGFsbW9sb2d5ZAIED2QWAmYPFQIeL29waHRoYWxtb2xvZ3kvcmV0aW5hLXZpdHJlb3VzD1JldGluYS9WaXRyZW91c2QCBg9kFgJmDxUCIy9vcGh0aGFsbW9sb2d5L3JldGluYS12aXRyZW91cy9uZXdzBE5ld3NkAgMPZBYCAgEPZBYCZg9kFhICAQ8WAh8ABU1NZXRhLWFuYWx5c2lzIGNvbXBhcmVzIHNhZmV0eSBwcm9maWxlcyBvZiByYW5pYml6dW1hYiBpbnRyYXZpdHJlYWwgaW5qZWN0aW9uc2QCAw8WAh8AZWQCBQ8WAh8AZWQCCQ8WAh8ABRFTZXB0ZW1iZXIgMywgMjAxM2QCCw8WAh8ABfgePHA+VE9ST05UTyAmbWRhc2g7IFJlc3VsdHMgb2YgYSBtZXRhLWFuYWx5c2lzIGNvbXBhcmluZyB0aGUgc2FmZXR5IHByb2ZpbGVzIG9mIGludHJhdml0cmVhbCByYW5pYml6dW1hYiBpbmplY3Rpb25zIGFyZSBjb25zaXN0ZW50IHdpdGggdGhlIGVzdGFibGlzaGVkIHN5c3RlbWljIHNhZmV0eSBwcm9maWxlIG9mIHJhbmliaXp1bWFiLCBhY2NvcmRpbmcgdG8gYSBwcmVzZW50ZXIgaGVyZS48L3A+CjxwPiZsZHF1bztJbnRyYXZpdHJlYWxseSwgdGhlcmUgYXJlIGNvbmNlcm5zIGFib3V0IHRoZSBwb3NzaWJpbGl0eSBvZiBzeXN0ZW1pYyBhZHZlcnNlIGV2ZW50cywgYnV0IHdlIGhhdmVuJnJzcXVvO3QgcmVhbGx5IGJlZW4gYWJsZSB0byBjYWxjdWxhdGUgYWNjdXJhdGVseSBiZWNhdXNlIG9mIHNhbXBsZSBzaXplLCZyZHF1bzsgPHN0cm9uZz5CYXJ1Y2ggRC4gS3VwcGVybWFubiwgTUQsPC9zdHJvbmc+IHRvbGQgY29sbGVhZ3VlcyBhdCB0aGUmbmJzcDs8YSBocmVmPSJodHRwOi8vd3d3LmhlYWxpby5jb20vb3BodGhhbG1vbG9neS9uZXdzL21lZXRpbmctbmV3cy1jb3ZlcmFnZT9zZXRpZD17NEJBNDUxNjItOEY4MS00NkVFLTkzOUItQzJCRTBEM0VGRjBFfSIgdGFyZ2V0PSJfYmxhbmsiPkFtZXJpY2FuIFNvY2lldHkgb2YgUmV0aW5hIFNwZWNpYWxpc3RzIG1lZXRpbmc8L2E+IGhlcmUuIDwvcD4KPHA+VG8gb3ZlcmNvbWUgdGhhdCBiYXJyaWVyLCBhIHBhaXJ3aXNlIGNvbXBhcmlzb24gb2YgMTQgcGhhc2UgMi8zIHJhbmRvbWl6ZWQgY2xpbmljYWwgdHJpYWxzIHdhcyB1bmRlcnRha2VuLCBsb29raW5nIGluIHBhcnRpY3VsYXIgZm9yIHNlcmlvdXMgYWR2ZXJzZSBldmVudHMgb2NjdXJyaW5nIGFmdGVyIGludHJhdml0cmVhbCBpbmplY3Rpb24gb2YgPGEgaHJlZj0iaHR0cDovL3d3dy5oZWFsaW8uY29tL29waHRoYWxtb2xvZ3kvc2VhcmNoLmFzcHg/cT1yYW5pYml6dW1hYiZhbXA7cmVxdWlyZWRmaWVsZHM9c3BlY2lhbHR5Ok9waHRoYWxtb2xvZ3kmYW1wO2NsaWVudD1oZWFsaW9fZnJvbnRlbmQmYW1wO3Byb3h5c3R5bGVzaGVldD1oZWFsaW9fZnJvbnRlbmRDTUUmYW1wO3NpdGU9aGVhbGlvLXByb2R1Y3Rpb24mYW1wO291dHB1dD14bWxfbm9fZHRkJmFtcDtscj1sYW5nX2VuJmFtcDtmaWx0ZXI9cCZhbXA7Z2V0ZmllbGRzPSomYW1wO2llPVVURi04JmFtcDtpcD0xOTIuMTY4LjEwMC4xNDQmYW1wO2FjY2Vzcz1wJmFtcDtlbnRxcj0zJmFtcDtvZT1VVEYtOCZhbXA7dWQ9MSZhbXA7c29ydD1kYXRlJTNBRCUzQVMlM0FkMSIgdGFyZ2V0PSJfYmxhbmsiPnJhbmliaXp1bWFiPC9hPiAoTHVjZW50aXMsIDxhIGhyZWY9Imh0dHA6Ly93d3cuaGVhbGlvLmNvbS9vcGh0aGFsbW9sb2d5L3NlYXJjaC5hc3B4P3E9R2VuZW50ZWNoJmFtcDtyZXF1aXJlZGZpZWxkcz1zcGVjaWFsdHk6T3BodGhhbG1vbG9neSZhbXA7Y2xpZW50PWhlYWxpb19mcm9udGVuZCZhbXA7cHJveHlzdHlsZXNoZWV0PWhlYWxpb19mcm9udGVuZENNRSZhbXA7c2l0ZT1oZWFsaW8tcHJvZHVjdGlvbiZhbXA7b3V0cHV0PXhtbF9ub19kdGQmYW1wO2xyPWxhbmdfZW4mYW1wO2ZpbHRlcj1wJmFtcDtnZXRmaWVsZHM9KiZhbXA7aWU9VVRGLTgmYW1wO2lwPTE5Mi4xNjguMTAwLjE0NCZhbXA7YWNjZXNzPXAmYW1wO2VudHFyPTMmYW1wO29lPVVURi04JmFtcDt1ZD0xJmFtcDtzb3J0PWRhdGUlM0FEJTNBUyUzQWQxIiB0YXJnZXQ9Il9ibGFuayI+R2VuZW50ZWNoPC9hPikuPC9wPgo8cD5UaGUgc2FmZXR5IG1ldGEtYW5hbHlzaXMgaW5jbHVkZWQgNiw1MDQgcGF0aWVudHMgcmVwcmVzZW50aW5nIDcsNTQ0IHBhdGllbnQteWVhcnMsIEt1cHBlcm1hbm4gc2FpZC4gVGhlIGludmVzdGlnYXRvcnMgbG9va2VkIGF0IDAuNS1tZyBhbmQgMC4zLW1nIGRvc2VzIG9mIHJhbmliaXp1bWFiIHZzLiBzaGFtLCBhcyB3ZWxsIGFzIDAuNSBtZyByYW5pYml6dW1hYiB2cy4gMC4zIG1nIHJhbmliaXp1bWFiLCBhcyB0cmVhdG1lbnQgZm9yIHdldCBhZ2UtcmVsYXRlZCBtYWN1bGFyIGRlZ2VuZXJhdGlvbiwgcmV0aW5hbCB2ZWluIG9jY2x1c2lvbiAoUlZPKSBhbmQgZGlhYmV0aWMgbWFjdWxhciBlZGVtYSAoRE1FKS48L3A+CjxwPk5vIGltYmFsYW5jZXMgd2VyZSBvYnNlcnZlZCBpbiB3ZXQgQU1EIG9yIFJWTyBmb3IgYW55IG9mIHRoZSBwcmVzcGVjaWZpZWQgc3lzdGVtaWMgZW5kcG9pbnRzIGV4YW1pbmVkLiBBbHRob3VnaCBvdmVyYWxsIGV2ZW50IHJhdGVzIHdlcmUgbG93IGZvciBETUUsIG51bWVyaWNhbCBpbWJhbGFuY2VzIGluIHBhaXJ3aXNlIGNvbXBhcmlzb25zIHdlcmUgb2JzZXJ2ZWQgaW4gc3Ryb2tlLCBkZWF0aCBhbmQgd291bmQgaGVhbGluZyBjb21wbGljYXRpb25zLCBhY2NvcmRpbmcgdG8gS3VwcGVybWFubi4gVGhlIGltYmFsYW5jZXMgZm9yIGRlYXRoIGFuZCBzdHJva2Ugd2VyZSBvYnNlcnZlZCBpbiB0aGUgc2Vjb25kIHllYXIgYW5kIHdlcmUgYmFzZWQgb24gcmVzdWx0cyBvZiB0aGUgUklTRSBhbmQgUklERSBzdHVkaWVzLCBpbiB3aGljaCByYW5pYml6dW1hYiB3YXMgYWRtaW5pc3RlcmVkIG1vbnRobHkgZm9yIDIgeWVhcnMsIGhlIHNhaWQuPC9wPgo8cD5JbmRlcGVuZGVudCBvZiB0cmVhdG1lbnQsIHBhdGllbnRzIHdpdGggRE1FIGFuZCBjZXJ0YWluIGNvbW9yYmlkaXRpZXMsIHN1Y2ggYXMgcHJpb3Igc3Ryb2tlLCB3ZXJlIGF0IGhpZ2hlciByaXNrIGZvciBzZXJpb3VzIGFkdmVyc2UgZXZlbnRzLiA8L3A+CjxwPlRoZSBtZXRhLWFuYWx5c2lzIGhhZCBzZXZlcmFsIGxpbWl0YXRpb25zLCBLdXBwZXJtYW5uIHNhaWQuIEV2YWx1YXRpb24gb2YgaW5mcmVxdWVudCBzeXN0ZW1pYyBhZHZlcnNlIGV2ZW50cyBjYW4gYmUgZGlmZmljdWx0IGJlY2F1c2UgdGhlc2UgZXZlbnRzIGFyZSBhbHNvIHNlZW4gaW4gdGhlIHRhcmdldCBwYXRpZW50IHBvcHVsYXRpb25zLiBUaGUgcG9vbGVkIHRyZWF0bWVudCByZWdpbWVucyBpbmNsdWRlZCBwYXRpZW50cyB3aXRoIGRpZmZlcmVudCBkb3NpbmcgZnJlcXVlbmNpZXMsIGFuZCBzb21lIHBhdGllbnRzIGFsc28gcmVjZWl2ZWQgcGhvdG9keW5hbWljIHRoZXJhcHkgbGFzZXIgdHJlYXRtZW50LiBBZGRpdGlvbmFsbHksIHRoZSBjb21iaW5lZCBzdHVkaWVzIHZhcmllZCBieSBkZXNpZ24sIHBhdGllbnQgcG9wdWxhdGlvbiwgY29udHJvbCBncm91cCwgZHVyYXRpb24gb2YgdHJlYXRtZW50LCBkb3NpbmcgZnJlcXVlbmN5LCBpbmNsdXNpb24gYW5kIGV4Y2x1c2lvbiBjcml0ZXJpYSBhbmQgcmVnaW9uLiBSaXNrIGZhY3RvcnMgd2VyZSBjb2xsZWN0ZWQgZGlmZmVyZW50bHkgYmV0d2VlbiBzdHVkaWVzLCBhbmQgc3lzdGVtaWMgZW5kcG9pbnRzIHdlcmUgYnJvYWRseSBkZWZpbmVkIHN1Y2ggdGhhdCBldmVudCByYXRlcyBtYXkgYmUgb3ZlcmVzdGltYXRlZCwgaGUgc2FpZC48L3A+CjxwPjxzdHJvbmc+RGlzY2xvc3VyZTo8L3N0cm9uZz4gRGF0YSBpbiB0aGUgcHJlc2VudGF0aW9uIGFyZSBwcm9wcmlldGFyeSB0byZuYnNwOzxhIGhyZWY9Imh0dHA6Ly93d3cuaGVhbGlvLmNvbS9vcGh0aGFsbW9sb2d5L3NlYXJjaC5hc3B4P3E9Tm92YXJ0aXMmYW1wO3JlcXVpcmVkZmllbGRzPXNwZWNpYWx0eTpPcGh0aGFsbW9sb2d5JmFtcDtjbGllbnQ9aGVhbGlvX2Zyb250ZW5kJmFtcDtwcm94eXN0eWxlc2hlZXQ9aGVhbGlvX2Zyb250ZW5kQ01FJmFtcDtzaXRlPWhlYWxpby1wcm9kdWN0aW9uJmFtcDtvdXRwdXQ9eG1sX25vX2R0ZCZhbXA7bHI9bGFuZ19lbiZhbXA7ZmlsdGVyPXAmYW1wO2dldGZpZWxkcz0qJmFtcDtpZT1VVEYtOCZhbXA7aXA9MTkyLjE2OC4xMDAuMTQ0JmFtcDthY2Nlc3M9cCZhbXA7ZW50cXI9MyZhbXA7b2U9VVRGLTgmYW1wO3VkPTEmYW1wO3NvcnQ9ZGF0ZSUzQUQlM0FTJTNBZDEiIHRhcmdldD0iX2JsYW5rIj5Ob3ZhcnRpczwvYT4gYW5kIEdlbmVudGVjaCwgYW5kIEt1cHBlcm1hbm4gaXMgYSBjb25zdWx0YW50IGZvciBib3RoIGNvbXBhbmllcy48L3A+ZAIPD2QWAgIBDxYCHwJoFgQCAQ8WAh8CaGQCBQ8WAh8CaGQCEQ9kFgJmDxYCHwNmZAITD2QWBgIBDxYCHgNzcmMFIS9+L21lZGlhL0ltYWdlcy9OZXdzL0ZvbGxvd1VzLmpwZ2QCAw8WAh8BBSlodHRwOi8vd3d3LmZhY2Vib29rLmNvbS9vY3VsYXJzdXJnZXJ5bmV3c2QCBQ8WAh8BBSBodHRwczovL3R3aXR0ZXIuY29tL09TTlN1cGVyU2l0ZWQCFw9kFgJmDxYCHwAFjgM8c2NyaXB0IGxhbmd1YWdlPSJqYXZhc2NyaXB0IiB0eXBlPSJ0ZXh0L2phdmFzY3JpcHQiPg0KICAgIHZhciBpZGNvbW1lbnRzX2FjY3QgPSAnYWE2ZmY1M2Y5ODcwZTQwZjkyZjgzZTFiNWRmM2NkZGYnOw0KICAgIHZhciBpZGNvbW1lbnRzX3Bvc3RfaWQgPSAnezI4MTQ3ODY0LURBMjUtNDk5My05QzhBLTdERDA1QUJDQzdBM30nOw0KICAgIHZhciBpZGNvbW1lbnRzX3Bvc3RfdXJsOw0KPC9zY3JpcHQ+DQo8c3BhbiBpZD0iSURDb21tZW50c1Bvc3RUaXRsZSIgc3R5bGU9ImRpc3BsYXk6IG5vbmUiPjwvc3Bhbj4NCjxzY3JpcHQgdHlwZT0ndGV4dC9qYXZhc2NyaXB0JyBzcmM9J2h0dHA6Ly93d3cuaW50ZW5zZWRlYmF0ZS5jb20vanMvZ2VuZXJpY0NvbW1lbnRXcmFwcGVyVjIuanMnPjwvc2NyaXB0PmQCBQ9kFgwCAQ9kFgJmD2QWAmYPZBYEAgEPZBYCZg8WAh8DAgMWBmYPZBYMZg8VAQBkAgEPZBYCZg8WAh8DAgEWAmYPZBYCZg8VAgRkZXB0D0luIHRoZSBKb3VybmFsc2QCAg8VA5wBL29waHRoYWxtb2xvZ3kvcmV0aW5hLXZpdHJlb3VzL25ld3Mvb25saW5lL3s2YmEyYzkyMy1mZTM2LTRiODctYmQ3Ni0zZGY1MDdlZTZhYWZ9L2VwaXJldGluYWwtbWVtYnJhbmUtc3VyZ2VyeS1zdWNjZXNzZnVsLWluLWV5ZXMtd2l0aC1vci13aXRob3V0LWhpZ2gtbXlvcGlhSkVwaXJldGluYWwgbWVtYnJhbmUgc3VyZ2VyeSBzdWNjZXNzZnVsIGluIGV5ZXMgd2l0aCBvciB3aXRob3V0IGhpZ2ggbXlvcGlhEVNlcHRlbWJlciA1LCAyMDEzZAIDDxYCHwJoFgJmDxUCkwFFcGlyZXRpbmFsIG1lbWJyYW5lIHN1cmdlcnkgeWllbGRlZCBzaW1pbGFyIGFuYXRvbWljIGFuZCB2aXN1YWwgb3V0Y29tZXMgYW5kIGNvbXBsaWNhdGlvbiByYXRlcyBpbiBoaWdobHkgbXlvcGljIGFuZCBub24taGlnaGx5IG15b3BpYyBleWVzIHdpdGhvdXScAS9vcGh0aGFsbW9sb2d5L3JldGluYS12aXRyZW91cy9uZXdzL29ubGluZS97NmJhMmM5MjMtZmUzNi00Yjg3LWJkNzYtM2RmNTA3ZWU2YWFmfS9lcGlyZXRpbmFsLW1lbWJyYW5lLXN1cmdlcnktc3VjY2Vzc2Z1bC1pbi1leWVzLXdpdGgtb3Itd2l0aG91dC1oaWdoLW15b3BpYWQCBA8WAh8CaBYCZg8VAQBkAgUPFQEAZAIBD2QWDGYPFQEAZAIBD2QWAmYPFgIfA2ZkAgIPFQM9aHR0cDovL3ZpZGVvLmhlYWxpby5jb20vdmlkZW8vY29udGVtcG9yYXJ5LW1hbmFnZW1lbnQtb2YtbWFzczxDb250ZW1wb3JhcnkgTWFuYWdlbWVudCBvZiBNYXNzaXZlIFN1YjgyMDhNYWN1bGFyIEhlbW9ycmhhZ2UQSmFudWFyeSAyNSwgMjAxM2QCAw8WAh8CaBYCZg8VAhdBbmRyZXcgQS4gTW9zaGZlZ2hpLCBNRD1odHRwOi8vdmlkZW8uaGVhbGlvLmNvbS92aWRlby9jb250ZW1wb3JhcnktbWFuYWdlbWVudC1vZi1tYXNzZAIEDxYCHwJoFgJmDxUBAGQCBQ8VAQBkAgIPZBYMZg8VAQBkAgEPZBYCZg8WAh8DAgEWAmYPZBYCZg8VAhpjdXJic2lkZS1jb25zdWx0YXRpb24tZmxhZxVDdXJic2lkZSBDb25zdWx0YXRpb25kAgIPFQNkL29waHRoYWxtb2xvZ3kvY3VyYnNpZGUtY29uc3VsdGF0aW9uL3szMTkzYmJiMC1mZWQ1LTQ2YzktODQxYi04MWJkMzEwYTE5OGN9L2hvdy1kby1pLXRyZWF0LWEtcGF0aWVudDNIb3cgRG8gSSBUcmVhdCBhIFBhdGllbnQgV2l0aCBPY3VsYXIgVG94b3BsYXNtb3Npcz8TR2FyeSBOLiBIb2xsYW5kLCBNRGQCAw8WAh8CaBYCZg8VApoBVG94b3BsYXNtYSBnb25kaWkgaXMgdGhlIG1vc3QgY29tbW9uIGNhdXNlIG9mIHJldGluYWwgaW5mZWN0aW9ucyBpbiBvdGhlcndpc2UgaGVhbHRoeSBpbmRpdmlkdWFscywgYW5kIGl0IGNhbiBjYXVzZSBzZXZlcmUsIGJsaW5kaW5nIGRpc2Vhc2UgaW4gdGhvc2Ugd2l0aGQvb3BodGhhbG1vbG9neS9jdXJic2lkZS1jb25zdWx0YXRpb24vezMxOTNiYmIwLWZlZDUtNDZjOS04NDFiLTgxYmQzMTBhMTk4Y30vaG93LWRvLWktdHJlYXQtYS1wYXRpZW50ZAIEDxYCHwJoFgJmDxUBAGQCBQ8VAQBkAgMPZBYCZg8WAh8DAgMWBmYPZBYMZg8VAQBkAgEPZBYCZg8WAh8DAgIWBGYPZBYCZg8VAgRkZXB0C0NvdmVyIFN0b3J5ZAIBD2QWAmYPFQIEZGVwdAxQQ09OIFJlcG9ydHNkAgIPFQOsAS9vcHRvbWV0cnkvY29ybmVhLWV4dGVybmFsLWRpc2Vhc2UvbmV3cy9wcmludC9wcmltYXJ5LWNhcmUtb3B0b21ldHJ5LW5ld3MvezU0Zjg1OGJkLTRhOWYtNDY4Zi1hOTYyLWZiYWFmZGY1ODllNH0vZGVtb2RleC1vZnRlbi1taXNkaWFnbm9zZWQtYXMtY2hyb25pYy1iYWN0ZXJpYWwtYmxlcGhhcml0aXM7RGVtb2RleCBvZnRlbiBtaXNkaWFnbm9zZWQgYXMgY2hyb25pYyBiYWN0ZXJpYWwgYmxlcGhhcml0aXMrUHJpbWFyeSBDYXJlIE9wdG9tZXRyeSBOZXdzLCBTZXB0ZW1iZXIgMjAxM2QCAw8WAh8CaBYCZg8VApgBQ2FzZXMgb2YgYW50ZXJpb3IgYmxlcGhhcml0aXMgdGhhdCBkbyBub3QgcmVzb2x2ZSB3aXRoIGFudGliaW90aWNzIG1heSBhY3R1YWxseSBiZSBjYXVzZWQgYnkgRGVtb2RleCBtaXRlcywgd2hpY2ggYXJlIG11Y2ggbW9yZSBwcmV2YWxlbnQgdGhhbiBnZW5lcmFsbHmsAS9vcHRvbWV0cnkvY29ybmVhLWV4dGVybmFsLWRpc2Vhc2UvbmV3cy9wcmludC9wcmltYXJ5LWNhcmUtb3B0b21ldHJ5LW5ld3MvezU0Zjg1OGJkLTRhOWYtNDY4Zi1hOTYyLWZiYWFmZGY1ODllNH0vZGVtb2RleC1vZnRlbi1taXNkaWFnbm9zZWQtYXMtY2hyb25pYy1iYWN0ZXJpYWwtYmxlcGhhcml0aXNkAgQPFgIfAmgWAmYPFQEAZAIFDxUBAGQCAQ9kFgxmDxUBAGQCAQ9kFgJmDxYCHwMCARYCZg9kFgJmDxUCBGRlcHQWV2hhdCdzIFlvdXIgRGlhZ25vc2lzP2QCAg8VA6EBL29wdG9tZXRyeS9yZXRpbmEtdml0cmVvdXMvbmV3cy9wcmludC9wcmltYXJ5LWNhcmUtb3B0b21ldHJ5LW5ld3Mve2NmMDEyMWQwLTRmMmYtNDEzNy1hNmY4LWUwMzMzNDk0NzExMX0vcGlnbWVudC1kcm9wb3V0LWZvdW5kLWluLW1pZGRsZS1hZ2VkLW1hbnMtZmlyc3QtZXllLWV4YW07UGlnbWVudCBkcm9wb3V0IGZvdW5kIGluIG1pZGRsZS1hZ2VkIG1hbuKAmXMgZmlyc3QgZXllIGV4YW0rUHJpbWFyeSBDYXJlIE9wdG9tZXRyeSBOZXdzLCBTZXB0ZW1iZXIgMjAxM2QCAw8WAh8CaBYCZg8VApgBQSA0NS15ZWFyLW9sZCBCdXJtZXNlIG1hbiBwcmVzZW50ZWQgd2l0aCBhIHRyYW5zbGF0b3IgZm9yIGhpcyBmaXJzdCBleWUgZXhhbWluYXRpb24uIEhpcyBjaGllZiBjb21wbGFpbnQgd2FzIGJsdXJyeSB2aXNpb24gYXQgbmlnaHQuIEhpcyBzeXN0ZW1pYyBoZWFsdGihAS9vcHRvbWV0cnkvcmV0aW5hLXZpdHJlb3VzL25ld3MvcHJpbnQvcHJpbWFyeS1jYXJlLW9wdG9tZXRyeS1uZXdzL3tjZjAxMjFkMC00ZjJmLTQxMzctYTZmOC1lMDMzMzQ5NDcxMTF9L3BpZ21lbnQtZHJvcG91dC1mb3VuZC1pbi1taWRkbGUtYWdlZC1tYW5zLWZpcnN0LWV5ZS1leGFtZAIEDxYCHwJoFgJmDxUBAGQCBQ8VAQBkAgIPZBYMZg8VAQBkAgEPZBYCZg8WAh8DZmQCAg8VA7EBL29waHRoYWxtb2xvZ3kvcmV0aW5hLXZpdHJlb3VzL25ld3MvcHJpbnQvcHJpbWFyeS1jYXJlLW9wdG9tZXRyeS1uZXdzL3tmZjUyZGIyOS1kMDNkLTRhZjQtODMxYS0xZDg5YjlkNDE4ZDl9L2lycmVndWxhci1leHRlcm5hbC1saW1pdGluZy1tZW1icmFuZS1tYXktYmUtYmlvbWFya2VyLWZvci1zdGFyZ2FyZHRzR0lycmVndWxhciBleHRlcm5hbCBsaW1pdGluZyBtZW1icmFuZSBtYXkgYmUgYmlvbWFya2VyIGZvciBTdGFyZ2FyZHTigJlzK1ByaW1hcnkgQ2FyZSBPcHRvbWV0cnkgTmV3cywgU2VwdGVtYmVyIDIwMTNkAgMPFgIfAmgWAmYPFQKXAUEgdGhpY2tlbmVkLCBpcnJlZ3VsYXIgYW5kIGh5cGVyLXJlZmxlY3RpdmUgZXh0ZXJuYWwgbGltaXRpbmcgbWVtYnJhbmUgY291bGQgcHJvdmUgdG8gYmUgdGhlIGVhcmxpZXN0IGNsaW5pY2FsIGluZGljYXRpb24gb2YgU3RhcmdhcmR0JnJzcXVvO3MgZGlzZWFzZSyxAS9vcGh0aGFsbW9sb2d5L3JldGluYS12aXRyZW91cy9uZXdzL3ByaW50L3ByaW1hcnktY2FyZS1vcHRvbWV0cnktbmV3cy97ZmY1MmRiMjktZDAzZC00YWY0LTgzMWEtMWQ4OWI5ZDQxOGQ5fS9pcnJlZ3VsYXItZXh0ZXJuYWwtbGltaXRpbmctbWVtYnJhbmUtbWF5LWJlLWJpb21hcmtlci1mb3Itc3RhcmdhcmR0c2QCBA8WAh8CaBYCZg8VAQBkAgUPFQEAZAIDD2QWAmYPFgIfAAXiATwhLS0gT3BodGhhbG1vbG9neV9SZXRpbmFWaXRyZW91c19NZWRpdW1SZWN0YW5nbGUgLS0+CjxkaXYgaWQ9J2Rpdi1ncHQtYWQtMTM2OTE2OTEzNDMwNi0zJz4KPHNjcmlwdCB0eXBlPSd0ZXh0L2phdmFzY3JpcHQnPgpnb29nbGV0YWcuY21kLnB1c2goZnVuY3Rpb24oKSB7Cmdvb2dsZXRhZy5kaXNwbGF5KCdkaXYtZ3B0LWFkLTEzNjkxNjkxMzQzMDYtMycpOwp9KTsKPC9zY3JpcHQ+CjwvZGl2PgpkAgUPZBYEZg9kFgJmD2QWAgIBD2QWAgIBD2QWAgIBDw8WAh4LTmF2aWdhdGVVcmwFIS9mb290ZXIvYWNjb3VudC1pbmZvcm1hdGlvbi9sb2dpbmRkAgEPZBYCZg9kFgICAQ8WAh8CZxYCAgEPFgIfAAWBBjxzY3JpcHQgdHlwZT0idGV4dC9qYXZhc2NyaXB0IiBjaGFyc2V0PSJ1dGYtOCIgc3JjPSJodHRwOi8vc3RhdGljLnBvbGxkYWRkeS5jb20vcC83MzcxNjI1LmpzIj48L3NjcmlwdD4KPG5vc2NyaXB0PjxhIGhyZWY9Imh0dHA6Ly9wb2xsZGFkZHkuY29tL3BvbGwvNzM3MTYyNS8iPkRvIHlvdSB0aGluayBmZWRlcmFsIHJlZ3VsYXRpb24gb2YgY29tcG91bmRpbmcgcGhhcm1hY2llcyB3aWxsIHJlZHVjZSB0aW1lbHkgYWNjZXNzIHRvIG1lZGljYXRpb25zPzwvYT48L25vc2NyaXB0PgoKCjxwPlJlYWQgPGEgaHJlZj0iaHR0cDovL3d3dy5oZWFsaW8uY29tL29waHRoYWxtb2xvZ3kvc2VhcmNoLmFzcHg/cT1jb21wb3VuZGluZytwaGFybWFjeSZyZXF1aXJlZGZpZWxkcz1zcGVjaWFsdHk6T3BodGhhbG1vbG9neSZjbGllbnQ9aGVhbGlvX2Zyb250ZW5kJnByb3h5c3R5bGVzaGVldD1oZWFsaW9fZnJvbnRlbmRDTUUmc2l0ZT1oZWFsaW8tcHJvZHVjdGlvbiZvdXRwdXQ9eG1sX25vX2R0ZCZscj1sYW5nX2VuJmZpbHRlcj1wJmdldGZpZWxkcz0qJmllPVVURi04JmlwPTE5Mi4xNjguMTAwLjUyJmFjY2Vzcz1wJmVudHFyPTMmb2U9VVRGLTgmdWQ9MSZzb3J0PWRhdGUlM0FEJTNBUyUzQWQxIj5yZWxhdGVkIGNvdmVyYWdlIG9uIGNvbXBvdW5kaW5nIHBoYXJtYWNpZXMuPC9hPjwvcD4KCgoKPHAgY2xhc3M9InBvbGwtcmVsYXRlZC1saW5rIj48YSBocmVmPSIvb3BodGhhbG1vbG9neS9wb2xsLWFyY2hpdmUiPlZpZXcgcGFzdCBwb2xscyAmcmFxdW87PC9hPjwvcD5kAgcPZBYEAgEPZBYCAgEPZBYCZg8WAh8ABc0BPCEtLSBPcGh0aGFsbW9sb2d5X1RleHRMaW5rMSAtLT4KPGRpdiBpZD0nZGl2LWdwdC1hZC0xMzY5MTY5MTM0MzA2LTYnPgo8c2NyaXB0IHR5cGU9J3RleHQvamF2YXNjcmlwdCc+Cmdvb2dsZXRhZy5jbWQucHVzaChmdW5jdGlvbigpIHsKZ29vZ2xldGFnLmRpc3BsYXkoJ2Rpdi1ncHQtYWQtMTM2OTE2OTEzNDMwNi02Jyk7Cn0pOwo8L3NjcmlwdD4KPC9kaXY+CmQCAg9kFgICAQ9kFgJmDxYCHwAFzQE8IS0tIE9waHRoYWxtb2xvZ3lfVGV4dExpbmsyIC0tPgo8ZGl2IGlkPSdkaXYtZ3B0LWFkLTEzNjkxNjkxMzQzMDYtNyc+CjxzY3JpcHQgdHlwZT0ndGV4dC9qYXZhc2NyaXB0Jz4KZ29vZ2xldGFnLmNtZC5wdXNoKGZ1bmN0aW9uKCkgewpnb29nbGV0YWcuZGlzcGxheSgnZGl2LWdwdC1hZC0xMzY5MTY5MTM0MzA2LTcnKTsKfSk7Cjwvc2NyaXB0Pgo8L2Rpdj4KZAIJD2QWAmYPFgIfAAXmATwhLS0gT3BodGhhbG1vbG9neV9SZXRpbmFWaXRyZW91c19NYXJrZXRpbmdSZWN0YW5nbGUxIC0tPgo8ZGl2IGlkPSdkaXYtZ3B0LWFkLTEzNjkxNjkxMzQzMDYtMSc+CjxzY3JpcHQgdHlwZT0ndGV4dC9qYXZhc2NyaXB0Jz4KZ29vZ2xldGFnLmNtZC5wdXNoKGZ1bmN0aW9uKCkgewpnb29nbGV0YWcuZGlzcGxheSgnZGl2LWdwdC1hZC0xMzY5MTY5MTM0MzA2LTEnKTsKfSk7Cjwvc2NyaXB0Pgo8L2Rpdj4KZAILD2QWAmYPFgIfAAXmATwhLS0gT3BodGhhbG1vbG9neV9SZXRpbmFWaXRyZW91c19NYXJrZXRpbmdSZWN0YW5nbGUyIC0tPgo8ZGl2IGlkPSdkaXYtZ3B0LWFkLTEzNjkxNjkxMzQzMDYtMic+CjxzY3JpcHQgdHlwZT0ndGV4dC9qYXZhc2NyaXB0Jz4KZ29vZ2xldGFnLmNtZC5wdXNoKGZ1bmN0aW9uKCkgewpnb29nbGV0YWcuZGlzcGxheSgnZGl2LWdwdC1hZC0xMzY5MTY5MTM0MzA2LTInKTsKfSk7Cjwvc2NyaXB0Pgo8L2Rpdj4KZAIRD2QWAgIBD2QWAmYPFgIfAAXkATwhLS0gT3BodGhhbG1vbG9neV9SZXRpbmFWaXRyZW91c19Cb3R0b21MZWFkZXJib2FyZCAtLT4KPGRpdiBpZD0nZGl2LWdwdC1hZC0xMzY5MTY5MTM0MzA2LTAnPgo8c2NyaXB0IHR5cGU9J3RleHQvamF2YXNjcmlwdCc+Cmdvb2dsZXRhZy5jbWQucHVzaChmdW5jdGlvbigpIHsKZ29vZ2xldGFnLmRpc3BsYXkoJ2Rpdi1ncHQtYWQtMTM2OTE2OTEzNDMwNi0wJyk7Cn0pOwo8L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href="https://web.archive.org/web/20130906135223/http://www.healio.com/ophthalmology/retina-vitreous/news/online/%7B33203905-ce75-4db8-8ed0-1c99466bd65a%7D/monthly-prn-doses-of-ranibizumab-similarly-effective-in-rvo">Monthly, PRN doses of ranibizumab similarly effective in RVO ...</a></li><li><a href="https://web.archive.org/web/20130906135223/http://www.healio.com/ophthalmology/retina-vitreous/news/online/%7Ba7020d0a-b315-4012-bed5-ae1c8ebb55de%7D/incidence-of-endophthalmitis-after-intravitreal-injection-greater-with-topical-antibiotic-use">Incidence of endophthalmitis after intravitreal injection greater ...</a></li></ul></div> <input name="layout_0$maincontent_0$seeAlsoInsertUnderParagraph" type="hidden" id="layout_0_maincontent_0_seeAlsoInsertUnderParagraph" value="1"/>  <div class="content"> <h2> Meta-analysis compares safety profiles of ranibizumab intravitreal injections</h2> <h3 class="deck"> </h3> <p class="main-subtitle"> </p> <div class="social-links-top"> <ul class="share"> <li class="l1"><a href="javascript:void(0)" class="facebook-link" target="_new">Facebook</a></li> <li class="l2"><a href="javascript:void(0)" class="twitter-link" target="_new">Tweet</a></li> <li class="l3"><a href="javascript:void(0)" class="linkedin-link">Share</a></li> </ul> </div> <ul class="meta-info"> <li> September 3, 2013</li> </ul> <div class="wyContent"> <p>TORONTO — Results of a meta-analysis comparing the safety profiles of intravitreal ranibizumab injections are consistent with the established systemic safety profile of ranibizumab, according to a presenter here.</p> <p>“Intravitreally, there are concerns about the possibility of systemic adverse events, but we haven’t really been able to calculate accurately because of sample size,” <strong>Baruch D. Kuppermann, MD,</strong> told colleagues at the <a href="https://web.archive.org/web/20130906135223/http://www.healio.com/ophthalmology/news/meeting-news-coverage?setid={4BA45162-8F81-46EE-939B-C2BE0D3EFF0E}" target="_blank">American Society of Retina Specialists meeting</a> here. </p> <p>To overcome that barrier, a pairwise comparison of 14 phase 2/3 randomized clinical trials was undertaken, looking in particular for serious adverse events occurring after intravitreal injection of <a href="https://web.archive.org/web/20130906135223/http://www.healio.com/ophthalmology/search.aspx?q=ranibizumab&requiredfields=specialty:Ophthalmology&client=healio_frontend&proxystylesheet=healio_frontendCME&site=healio-production&output=xml_no_dtd&lr=lang_en&filter=p&getfields=*&ie=UTF-8&ip=192.168.100.144&access=p&entqr=3&oe=UTF-8&ud=1&sort=date%3AD%3AS%3Ad1" target="_blank">ranibizumab</a> (Lucentis, <a href="https://web.archive.org/web/20130906135223/http://www.healio.com/ophthalmology/search.aspx?q=Genentech&requiredfields=specialty:Ophthalmology&client=healio_frontend&proxystylesheet=healio_frontendCME&site=healio-production&output=xml_no_dtd&lr=lang_en&filter=p&getfields=*&ie=UTF-8&ip=192.168.100.144&access=p&entqr=3&oe=UTF-8&ud=1&sort=date%3AD%3AS%3Ad1" target="_blank">Genentech</a>).</p> <p>The safety meta-analysis included 6,504 patients representing 7,544 patient-years, Kuppermann said. The investigators looked at 0.5-mg and 0.3-mg doses of ranibizumab vs. sham, as well as 0.5 mg ranibizumab vs. 0.3 mg ranibizumab, as treatment for wet age-related macular degeneration, retinal vein occlusion (RVO) and diabetic macular edema (DME).</p> <p>No imbalances were observed in wet AMD or RVO for any of the prespecified systemic endpoints examined. Although overall event rates were low for DME, numerical imbalances in pairwise comparisons were observed in stroke, death and wound healing complications, according to Kuppermann. The imbalances for death and stroke were observed in the second year and were based on results of the RISE and RIDE studies, in which ranibizumab was administered monthly for 2 years, he said.</p> <p>Independent of treatment, patients with DME and certain comorbidities, such as prior stroke, were at higher risk for serious adverse events. </p> <p>The meta-analysis had several limitations, Kuppermann said. Evaluation of infrequent systemic adverse events can be difficult because these events are also seen in the target patient populations. The pooled treatment regimens included patients with different dosing frequencies, and some patients also received photodynamic therapy laser treatment. Additionally, the combined studies varied by design, patient population, control group, duration of treatment, dosing frequency, inclusion and exclusion criteria and region. Risk factors were collected differently between studies, and systemic endpoints were broadly defined such that event rates may be overestimated, he said.</p> <p><strong>Disclosure:</strong> Data in the presentation are proprietary to <a href="https://web.archive.org/web/20130906135223/http://www.healio.com/ophthalmology/search.aspx?q=Novartis&requiredfields=specialty:Ophthalmology&client=healio_frontend&proxystylesheet=healio_frontendCME&site=healio-production&output=xml_no_dtd&lr=lang_en&filter=p&getfields=*&ie=UTF-8&ip=192.168.100.144&access=p&entqr=3&oe=UTF-8&ud=1&sort=date%3AD%3AS%3Ad1" target="_blank">Novartis</a> and Genentech, and Kuppermann is a consultant for both companies.</p> </div>  <div class="fig left"> <p class="figcaption"> </p> </div> <div class="wyPagination">   </div>  <div class="follow"> <img src="/web/20130906135223im_/http://www.healio.com/~/media/Images/News/FollowUs.jpg" id="layout_0_maincontent_1_SocialFollow_socialfollow" name="socialfollow" alt="Follow us" usemap="#followus" border="0"/> <map id="followus" name="followus"> <area id="layout_0_maincontent_1_SocialFollow_followfb" shape="rect" coords="51,5,5,51" target="_blank" href="https://web.archive.org/web/20130906135223/http://www.facebook.com/ocularsurgerynews" alt="Follow us on Facebook"></area> <area id="layout_0_maincontent_1_SocialFollow_followtw" shape="rect" coords="241,3,281,50" target="_blank" href="https://web.archive.org/web/20130906135223/https://twitter.com/OSNSuperSite" alt="Follow us on Twitter"></area> </map> </div> </div>  <div class="social-links"> <div class="fb-like" data-send="false" data-width="300" data-show-faces="true" data-action="recommend"></div> <ul class="share"> <li><a href="javascript:void(0)" id="twitter" class="twitter-link" target="_new">Tweet</a></li> <li><a href="javascript:void(0)" id="facebook" class="facebook-link" target="_new">Share</a></li> <li class="linkedin"><a href="javascript:void(0)" id="linkedin" class="linkedin-link">Link</a></li> <li><span class="db-wrapper"><span class="g-plusone" data-size="tall" data-annotation="none"></span></span></li> <li><a href="javascript:void(0)" id="email">Email</a></li> <li class="last"><a href="javascript:void(0)" id="print">Print</a></li> </ul> <input name="layout_0$maincontent_1$SocialMedia$articleItemForTweet" type="hidden" id="layout_0_maincontent_1_SocialMedia_articleItemForTweet" value="{28147864-DA25-4993-9C8A-7DD05ABCC7A3}"/> </div>  <div id="respond"> <h4> Comments</h4> <script language="javascript" type="text/javascript"> var idcomments_acct = 'aa6ff53f9870e40f92f83e1b5df3cddf'; var idcomments_post_id = '{28147864-DA25-4993-9C8A-7DD05ABCC7A3}'; var idcomments_post_url; </script> <span id="IDCommentsPostTitle" style="display: none"></span> <script type="text/javascript" src="https://web.archive.org/web/20130906135223js_/http://www.intensedebate.com/js/genericCommentWrapperV2.js"></script> <p class="comment-notes"> Healio is intended for health care provider use and all comments will be posted at the discretion of the editors. 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Meta-analysis compares safety profiles of ranibizumab intravitreal injections | Ophthalmology