Search results for: Lumir Kunovsky

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class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Lumir Kunovsky</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Association of Mir-196a Expression in Esophageal Tissue with Barrett´s Esophagus and Esophageal Adenocarcinoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Petra%20Borilova%20Linhartova">Petra Borilova Linhartova</a>, <a href="https://publications.waset.org/abstracts/search?q=Michaela%20Ruckova"> Michaela Ruckova</a>, <a href="https://publications.waset.org/abstracts/search?q=Sabina%20Sevcikova"> Sabina Sevcikova</a>, <a href="https://publications.waset.org/abstracts/search?q=Natalie%20Mlcuchova"> Natalie Mlcuchova</a>, <a href="https://publications.waset.org/abstracts/search?q=Jan%20Bohm"> Jan Bohm</a>, <a href="https://publications.waset.org/abstracts/search?q=Katerina%20Zukalova"> Katerina Zukalova</a>, <a href="https://publications.waset.org/abstracts/search?q=Monika%20Vlachova"> Monika Vlachova</a>, <a href="https://publications.waset.org/abstracts/search?q=Jiri%20Dolina"> Jiri Dolina</a>, <a href="https://publications.waset.org/abstracts/search?q=Lumir%20Kunovsky"> Lumir Kunovsky</a>, <a href="https://publications.waset.org/abstracts/search?q=Radek%20Kroupa"> Radek Kroupa</a>, <a href="https://publications.waset.org/abstracts/search?q=Zdenek%20Pavlovsky"> Zdenek Pavlovsky</a>, <a href="https://publications.waset.org/abstracts/search?q=Zdenek%20Danek"> Zdenek Danek</a>, <a href="https://publications.waset.org/abstracts/search?q=Tereza%20Deissova"> Tereza Deissova</a>, <a href="https://publications.waset.org/abstracts/search?q=Lydie%20Izakovicova%20Holla"> Lydie Izakovicova Holla</a>, <a href="https://publications.waset.org/abstracts/search?q=Ondrej%20Slaby">Ondrej Slaby</a>, <a href="https://publications.waset.org/abstracts/search?q=Zdenek%20Kala"> Zdenek Kala</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy that frequently develops from Barrett's esophagus (BE), a premalignant pathologic change occurring in the lower end of the esophagus. Specific microRNAs (miRNAs), small non-coding RNAs that function as posttranscriptional regulators of gene expression, were repeatedly proved to play key roles in the pathogenesis of these diseases. This pilot study aimed to analyze four selected miRNAs in esophageal tissues from healthy controls (HC) and patients with reflux esophagitis (RE)/BE/EAC, as well as to compare expression at the site of Barrett's mucosa/adenocarcinoma and healthy esophageal tissue outside the area of the main pathology in patients with BE/EAC. In this pilot study, 22 individuals (3 HC, 8 RE, 5 BE, 6 EAC) were included and endoscopically examined. RNA was isolated from the fresh-frozen esophageal tissue (stored in the RNAlater™ Stabilization Solution −70°C) using the AllPrep DNA/RNA/miRNA Universal Kit. Subsequent RT-qPCR analysis was performed using selected TaqMan MicroRNA Assays for miR-21, miR-34a, miR-196a, miR-196b, and endogenous control (RNU44). While the expression of miR-21 in the esophageal tissue with the main pathology was decreased in BE and EAC patients in comparison to the group of HC and RE patients (p=0.01), the expression of miR-196a was increased in the BE and EAC patients (p<0.01). Correlations between those miRNAs expression in tissue and severity of diagnosis were observed (p<0.05). In addition, miR-196a was significantly more expressed at the site with the main pathology than in paired adjacent esophageal tissue in BE and EAC patients (p<0.01). In conclusion, our pilot results showed that miR-196a, which regulates the proliferation, invasion, and migration (and was previously associated with esophageal squamous cell carcinoma and marked as a potential therapeutic target), could be a diagnostic tissue biomarker for BE and EAC as well. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=microRNA" title="microRNA">microRNA</a>, <a href="https://publications.waset.org/abstracts/search?q=barrett%C2%B4s%20esophagus" title=" barrett´s esophagus"> barrett´s esophagus</a>, <a href="https://publications.waset.org/abstracts/search?q=esophageal%20adenocarcinoma" title=" esophageal adenocarcinoma"> esophageal adenocarcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=biomarker" title=" biomarker"> biomarker</a> </p> <a href="https://publications.waset.org/abstracts/149454/association-of-mir-196a-expression-in-esophageal-tissue-with-barretts-esophagus-and-esophageal-adenocarcinoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/149454.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">119</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational 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Search results for: Lumir Kunovsky