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class="SidebarNav-item"> <a href="/services" class="SidebarNav-link">About our Services</a> </li> <li class="SidebarNav-item"> <a href="/services/discovery-based-proteomics" class="SidebarNav-link">Discovery Based Proteomics</a> </li> <li class="SidebarNav-item"> <a href="/services/single-cell-proteomcs" class="SidebarNav-link">Single Cell Proteomics</a> </li> <li class="SidebarNav-item"> <a href="/services/speciality-proteomics" class="SidebarNav-link">Speciality Proteomics</a> </li> <li class="SidebarNav-item"> <a href="/services/" class="SidebarNav-link">Targeted Assays</a> </li> <li class="SidebarNav-item"> <a href="/services/quality-management" class="SidebarNav-link">Quality Management</a> </li> <li class="SidebarNav-item"> <a href="/services/bioinformatics-package" class="SidebarNav-link">Bioinformatics</a> </li> <li class="SidebarNav-item is-last is-currentParent is-firstParent"> <a href="/services/" class="is-last is-currentParent is-firstParent SidebarNav-link">Working with us</a> <ul> <li class="SidebarNav-item is-first is-current"> <a href="/services/working-with-us" class="is-first is-current SidebarNav-link">Summary of our Proteomic Servies</a> </li> <li class="SidebarNav-item"> <a href="/services/working-with-us/types-and-quantities-of-samples-required-for-analysis" class="SidebarNav-link">Types and Quantities of Samples Required for Analysis</a> </li> <li class="SidebarNav-item"> <a href="/services/how-to-work-with-us" class="SidebarNav-link">How to discuss and order a project with us</a> </li> <li class="SidebarNav-item is-last"> <a href="/services/how-to-work-with-us/working-with-us" class="is-last SidebarNav-link">Sample analysis and reporting</a> </li> </ul> </li> </ul> <div class="SidebarSection"> <h2 class="SidebarSection-title"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-chemistry" /></svg><span class="u-alignMiddle">Related Technologies</span></h2> <ul class="List"> <li> <a class="SidebarSection-link" href=""></a> </li> </ul> </div> <div class="SidebarSection"> <h2 class="SidebarSection-title"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-clipboard" /></svg><span class="u-alignMiddle">Resources</span></h2> <ul class="List"> <li> <a class="SidebarSection-link" href="/resources/case-studies">Case Studies</a> </li> <li> <a class="SidebarSection-link" href="/resources/publications">Publications</a> </li> <li> <a class="SidebarSection-link" href="/resources/posters">Posters</a> </li> <li> <a class="SidebarSection-link" href="/resources/faqs">FAQs</a> </li> </ul> </div> <div class="u-textCenter u-padTop1"> <a class="Button" href="/contact">contact us for more information</a> </div> </aside> <p>Proteome Sciences plc is a global leader in Mass Spectrometry based proteomics. We have over 25 years’ experience in generating and analysing mass spectrometry proteomic data. We developed and now solely manufacture Tandem Mass Tags (TMT) which are used by proteomic groups globally to provide the most accurate quantitative proteomics datasets. We are the only global based service provider offering TMTpro 18plex tags in our workflows. TMT’s provide greater analytical consistency and importantly allows inclusion of a common reference sample to normalise data between batches in large cohort studies. A range of pre-analytical and in-process quality control tests ensure optimum performance and identifies any drivers of technical variance prior to analysis.</p> <p>Our Computational Proteomics modules are based on industry-standard software for peptide sequence assignment and localisation of post-translational modifications. We also provide bespoke searching strategies to improve the efficiency of identification of multiple post-translational modifications that regulate key biological processes.</p> <p>We have developed one of the most advanced set of bioinformatics tools for proteomic data analysis with thresholds based on the study data distribution rather than arbitrary selection. Data pre-processing, normalisation and modelling is performed with rigorous attention to detail. All software has been quality controlled and undergoes routine computer systems validation prior to release. Data logs are kept for all processes and all inputs and outputs are stored for retrospective analysis as required. As a result we produce the highest quality proteomics data currently available.</p> <p>Workflows that are based on our services are divided into five key areas;</p> <ul> <li>Incoming sample receipt and QC</li> <li>protein extraction, peptide generation and TMT peptide labelling (where applicable)</li> <li>advanced high resolution <a href="/services/discovery-based-proteomics/tmt-based-experiments">TMT based</a> mass spectrometry</li> <li>detailed computational proteomic analysis and comprehensive bioinformatics included in the cost of the analysis</li> <li>a comprehensive report concludes the project. An example service report is here. Mass spectrometric raw data from the analysis and bioinformatics is included in Excel based QuantSheet</li> </ul> <p>Mass Spectrometric based raw and processed data from</p> <ul> <li>Unbiased Discovery work is performed under <a href="/services/quality-management/iso-ceritifcation">ISO 2001-2015</a>.</li> <li>Clinical Targeted work can be performed under <a href="/services/quality-management/gclp-certification">Good Clinical Laboratory Practice (GCLP)</a> if required.</li> </ul> <table class="Table--themed" style="border-collapse: collapse; width: 99.9211%;" border="1"> <thead> <tr> <th style="width: 32.8069%;" scope="col">Application</th> <th style="width: 32.8069%;" scope="col">Service</th> <th style="width: 32.8076%;" scope="col">Description</th> </tr> </thead> <tbody> <tr> <td style="width: 32.8069%;">Fluid Biomarker Unbiased Discovery</td> <td style="width: 32.8069%;"><a href="/services/discovery-based-proteomics/super-depletion">TMT Super Depletion</a><br><a href="/services/tmtcalibrator-workflow">TMTcalibrator</a><br><a href="/services/tmt-ms2-workflow">TMT LC-MS2</a><br><a href="/services/tmt-ms3-workflow">TMT LC-MS3</a></td> <td style="width: 32.8076%;">Highest level of abundant protein depletion<br>Highest sample multiplexing – TMTpro 18-plex<br>From 10 to 100+ samples<br>Tissue-enhanced low abundance fluid proteomics<br>Most accurate MS3-based quantification</td> </tr> <tr> <td style="width: 32.8069%;">Disease Profiling and Target Discovery</td> <td style="width: 32.8069%;"><a href="/services/sysquant-workflow">SysQuant</a><br><a href="/services/tmt-ms2-workflow">TMT LC-MS2</a><br><a href="/services/tmt-ms3-workflow">TMT LC-MS3</a></td> <td style="width: 32.8076%;"> <p>Enriched PTM proteomics</p> <ul> <li>phosphorylation</li> <li>acetylation</li> <li>methylation</li> <li>hydroxylation</li> <li>ubiquitylation</li> <li>glycosylation</li> </ul> <p>Highest sample multiplexing – TMTpro 18-plex<br>Most accurate LC-MS3 based quantification</p> </td> </tr> <tr> <td style="width: 32.8069%;">Target Engagement and Mechanism of Action Analysis</td> <td style="width: 32.8069%;"><a href="/services/sysquant-workflow">SysQuant</a><br><a href="/services/tmt-ms2-workflow">TMT LC-MS2</a><br><a href="/services/tmt-ms3-workflow">TMT LC-MS3</a><br><a href="/services/srm">PRM/SRM Targeted Assays</a></td> <td style="width: 32.8076%;">Enriched PTM proteomics<br>Highest sample multiplexing – TMTpro 18-plex<br>Most accurate MS3-based quantification</td> </tr> <tr> <td style="width: 32.8069%;">Routine Biomarker Assays</td> <td style="width: 32.8069%;"><a href="/services/srm">PRM/SRM Targeted Assays</a></td> <td style="width: 32.8076%;">Rapid assay set up<br>High sensitivity and specificity<br>Multiple protein readout in one assay (multiplex)<br>Validated to GCLP</td> </tr> <tr> <td style="width: 32.8069%;">Biotherapeutic Manufacturing</td> <td style="width: 32.8069%;"><a href="/services/tmt-ms2-workflow">TMT<sup> </sup>LC-MS2</a><br><a href="/services/tmt-ms3-workflow">TMT LC-MS3</a><br>Label-free quantification<br>PAGE/Western blot/ELISA</td> <td style="width: 32.8076%;">Bespoke analytical services</td> </tr> <tr> <td style="width: 32.8069%;">Data Analysis / Bioinformatics</td> <td style="width: 32.8069%;">DIANA<br>CalDIT<br>FeaST<br>FAT</td> <td style="width: 32.8076%;">Data normalisation & integration<br>Exploratory analysis<br>Linear modelling<br>Functional enrichment</td> </tr> </tbody> </table> <p>A general article published in the July 2019 edition of EBR magazine that describes our company and services can be found <a href="https://cdn.securesyte.com/JxEdylMPMz-1515/docs/EBR-July-2019.pdf" rel="noopener noreferrer" target="_blank">here</a>. Proteome Sciences plc Mass Spectrometry Based Proteomics</p> <aside class="Sidebar u-hidden u-md-show"><div class="SidebarSection"> <h2 class="SidebarSection-title"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-chemistry" /></svg><span class="u-alignMiddle">Related Technologies</span></h2> <ul class="List"> <li> <a class="SidebarSection-link" href=""></a> </li> </ul> </div> <div class="SidebarSection"> <h2 class="SidebarSection-title"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-clipboard" /></svg><span class="u-alignMiddle">Resources</span></h2> <ul class="List"> <li> <a class="SidebarSection-link" href="/resources/case-studies">Case Studies</a> </li> <li> <a class="SidebarSection-link" href="/resources/publications">Publications</a> </li> <li> <a class="SidebarSection-link" href="/resources/posters">Posters</a> </li> <li> <a class="SidebarSection-link" href="/resources/faqs">FAQs</a> </li> </ul> </div> <div class="u-textCenter u-padTop1"> <a class="Button" href="/contact">contact us for more information</a> </div> </aside> </div> </div> <div class="u-colorBackgroundGray u-padTop4 u-padBottom4"> <div class="Container u-gutters1"> <div class="u-textCenter u-redline u-sm-padTop2"><h2 class="u-margBottom0"><span class="u-alignMiddle">Case studies</span></h2><span class="u-subTitle">Turning problems into solutions</span></div> <div id="js-displaySlider-wtjGWv" class="DisplaySlider"> <div class="DisplaySlider-slide"><h3 class="u-redlineLeftSm"> Profiling New Drug Targets for Alzheimer’s Disease </h3><a href="/resources/case-studies/item/profiling-new-drug-targets-for-alzheimer-s-disease">Goal – Identify key regulatory pathways and proteins that mediate damage related to hyper-phosphorylated tau in human brain tissue. Outcome –…</a></div><div class="DisplaySlider-slide DisplaySlider-slide--hidden"><h3 class="u-redlineLeftSm"> Stacking the Odds in Alzheimer’s Disease Drug Development </h3><a href="/resources/case-studies/item/stacking-the-odds-in-alzheimer-s-disease-drug-development-2">Goal – Establish the mechanism of action of two orally available, brain-penetrant small molecule inhibitors of casein kinase 1 delta that improved cognition…</a></div><div class="DisplaySlider-slide DisplaySlider-slide--hidden"><h3 class="u-redlineLeftSm"> Unravelling the Mechanism of Action of Combined Targets in Melanoma </h3><a href="/resources/case-studies/item/unravelling-the-mechanism-of-action-of-combined-targets-in-melanoma">Goal – Analyse the context in which melanoma-derived cell lines exploit MEK and PI3K signalling to overcome BRAF V600E resistance. Outcome – Identification…</a></div><div class="DisplaySlider-slide DisplaySlider-slide--hidden"><h3 class="u-redlineLeftSm"> Translating Experimental Model Data to Human Disease </h3><a href="/resources/case-studies/item/translating-experimental-model-data-to-human-disease">Goal – Establish common mechanisms of actions between preclinical mice treated with CK1D inhibitors and post mortem human AD brain tissue. Outcome – With…</a></div><div class="DisplaySlider-slide DisplaySlider-slide--hidden"><h3 class="u-redlineLeftSm"> The Hunt for Early Diagnostic Biomarkers of AD </h3><a href="/resources/case-studies/item/the-hunt-for-early-diagnostic-biomarkers-of-ad">Goal – Profile protein markers of neuroinflammation in AD cerebrospinal fluid. Outcome – Identification of 41 proteins with at least 60% regulation in AD…</a></div><div class="DisplaySlider-slide DisplaySlider-slide--hidden"><h3 class="u-redlineLeftSm"> Clusterin Glycosylation – A Prognostic AD Plasma Biomarker </h3><a href="/resources/case-studies/item/clusterin-glycosylation-a-prognostic-ad-plasma-biomarker">Goal – Characterize plasma clusterin glycosylation associated with increasing brain atrophy. 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