NDCN Collaborative Pairs - Chan Zuckerberg Initiative

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href="https://chanzuckerberg.com/science/programs-resources/neuroscience/" target="_self" class="button-cta button-cta-- button-cta--back_minimal_arrow_only " title="NEUROSCIENCE PROGRAM PAGE" aria-label="" > <div class="button-cta__text " >NEUROSCIENCE PROGRAM PAGE</div> <div class="button-cta__arrow cta-arrow cta-arrow--red "> <div class="cta-arrow__bkg"></div> </div> </a> </div> <div class="rfa__intro-back-btn funding-btn"> <a href="https://chanzuckerberg.com/science/science-funding/" target="_self" class="button-cta button-cta-- button-cta--back_minimal_arrow_only " title="SCIENCE GRANT RESOURCES PAGE" aria-label="" > <div class="button-cta__text " >SCIENCE GRANT RESOURCES PAGE</div> <div class="button-cta__arrow cta-arrow cta-arrow--red "> <div class="cta-arrow__bkg"></div> </div> </a> </div> <h1 class="rfa__intro-title">Collaborative Pairs Pilot Project Awards (Cycle 2)</h1> <div class="rfa__intro-content t-body--large"> <p class="t-body--large"><span>The Chan Zuckerberg Initiative invites applications for the second cycle of the Collaborative Pairs Pilot Project Awards. These grant awards support pairs of investigators and their teams to explore innovative, interdisciplinary approaches to address critical challenges in the fields of neurodegenerative disease and fundamental neuroscience. Awards are $200,000 in total costs per collaborating pair for a period of 18 months, after which successful projects will be eligible to apply for additional four-year acceleration grants that build on pilot phase studies. Collaborative Pairs teams will benefit from the support, mentoring and collaborative interactions of the Challenge Network, as well as interactions with the broader CZ Science programs and grantee network.</span> </p> <p class="t-body--large"><span>The CZI Neurodegeneration Challenge Network (NDCN) was launched in 2018 as a new type of collaborative research network that brings together biologists, computational scientists, engineers, and physicians from across broad research areas who are motivated by collaboration and open science to tackle unsolved challenges in neurodegenerative disease. Collaboration has been at the core of the vision for the Challenge Network approach and in developing the NDCN program strategy, we have sought to develop funding mechanisms that motivate and support novel collaborative approaches that will lead to bold, innovative, risk-taking science.</span> </p> <p class="t-body--large">For more information, watch the <a href="https://chanzuckerberg.wistia.com/medias/207923vprr" target="_blank" rel="noopener">informational webinar</a> and <a href="https://drive.google.com/file/d/14ZQO-LzBvCp13aYRo-IdFbc2RM1_x7tp/view?usp=sharing" target="_blank" rel="noopener">read the FAQ</a>. </p> <p class="t-body--large"><ul> <li>Learn about <a href="https://chanzuckerberg.com/science/programs-resources/neurodegeneration-challenge/projects/?award=collaborative-pairs-pilot-project,collaborative-pairs-pilot-project-phase-2" target="_blank" rel="noopener">our Cycle 1 grantees</a> and view the previous <a href="https://apply.chanzuckerberg.com/protected/nr/wQqFm/NDCN_Collab_Pairs_RFA_Annoucement_and_Instructions_COMBINED_-_CLOSED.pdf" target="_blank" rel="noopener">Cycle 1 RFA</a>.</li> <li>Learn about <a href="https://chanzuckerberg.com/science/programs-resources/neurodegeneration-challenge/projects/?award=collaborative-pairs-pilot-project-cycle-2-phase-1" target="_blank" rel="noopener">our Cycle 2 grantees</a>.</li> </ul> </p> </div> </div> <div class="rfa__contact rfa__reference mobile-only"> <div class="rfa__reference-inner"> <h5 class="rfa__reference-title">RFA Contact</h5> <div class="contact__paragraphs"> <p class="t-body--large"><span>For administrative and programmatic inquiries, or other questions pertaining to this RFA, please </span><span>contact </span><a href="mailto:sciencegrants@chanzuckerberg.com"><span>sciencegrants@chanzuckerberg.com</span></a><span>.</span> </p> </div> </div> </div> <div class="rfa__dates rfa__reference mobile-only"> <div class="rfa__reference-inner"> <div class="rfa__reference-header"> <h5 class="rfa__reference-title">Key Dates</h5> </div> <div class="dates__list"> <div class="dates__date"> <div class="date__date">May 9, 2023</div> <div class="date__description t-body--large">Letter of Intent (LOI) application portal opens</div> </div> <div class="dates__date"> <div class="date__date">June 22, 2023</div> <div class="date__description t-body--large">LOIs due by 5 P.M. (Pacific Time)</div> </div> <div class="dates__date"> <div class="date__date">Mid-August 2023</div> <div class="date__description t-body--large">LOI decisions announced<br />Full application portal opens</div> </div> <div class="dates__date"> <div class="date__date">September 21, 2023</div> <div class="date__description t-body--large">Applications due by 5 P.M. (Pacific Time)</div> </div> <div class="dates__date"> <div class="date__date">January 2024</div> <div class="date__description t-body--large">Earliest notification of decisions (subject to change)</div> </div> <div class="dates__date"> <div class="date__date">March 1, 2024</div> <div class="date__description t-body--large">Expected start date of award period (subject to change)</div> </div> </div> <div class="dates__information"> <p class="t-body--large"><span>Award period and start date: Proposed projects should be 18 months in duration with a projected start date no earlier than March 1, 2024. Actual start date may vary.</span> </p> <p class="t-body--large"><strong>IMPORTANT DOCUMENTS</strong> </p> <p class="t-body--large"><a href="https://apply.chanzuckerberg.com/protected/r/FkmBTc_C-GJ6iD28zx8OmMjdxwM6qbz1XFuiwusn6cZ4-RtQsIF4fyppqdL_YJHr5w1j0AWL9r4AgoqkIkHxgQ==/NDCN_Collaborative_Pairs_Cycle_2_Instructions_revised_8_4_2023.pdf" target="_blank" rel="noopener">Application Instructions</a><br /> <a href="https://apply.chanzuckerberg.com/protected/resource/eyJoZnJlIjogOTQ1ODEyNDksICJ2cSI6IDE2ODQ2Nn0/" target="_blank" rel="noopener">Institutional Approval Form</a> </p> </div> </div> </div> <div class="rfa__accordions"> <section class="section--accordions section--accordions--half section--border-bottom section--"> <div class="accordion accordion--half" accordion id="opportunity"> <div class="accordion__heading" accordion-heading tabindex="0"> <h5 class="t-h5--semibold">Opportunity</h5> <div class="accordion__icon"></div> </div> <div class="accordion__content" accordion-content> <div class="accordion__content-wrap"> <p><b>Overview</b></p> <p><span style="font-weight: 400">The CZI </span><a href="https://cziscience.medium.com/a-new-approach-to-solving-neurodegeneration-2aa50654ed04?source=friends_link&sk=4bb632f9e7d1e7dddbace5d83ac547e7" target="_blank" rel="noopener"><span style="font-weight: 400">Neurodegeneration Challenge Network</span></a><span style="font-weight: 400"> (NDCN) was launched in 2018 as a new type of collaborative research network</span><span style="font-weight: 400"> that brings together biologists, computational scientists, engineers, and physicians from across broad research areas who are motivated by collaboration and open science to tackle unsolved challenges in neurodegenerative disease. </span><span style="font-weight: 400">Collaboration has been at the core of the vision for the Challenge Network approach and in developing the NDCN program strategy, we have sought to develop funding mechanisms that motivate and support novel collaborative approaches that will lead to bold, innovative, risk-taking science. </span></p> <p><span style="font-weight: 400">The</span><b> Collaborative Pairs Pilot Project Awards</b> <span style="font-weight: 400">were developed as a funding mechanism to catalyze new collaborations and scientific partnerships and springboard early-stage projects that are bold, creative and “out-of-the-box.” </span><span style="font-weight: 400">We recognize that great collaborations can take many forms — from teams of two to large consortia and everything in between.</span><span style="font-weight: 400"> The Collaborative Pairs mechanism focuses specifically on pairs of investigators.</span><span style="font-weight: 400"> While scientific creativity is often represented as emanating from a singular lone genius, science works best when it is a collaborative effort, and it’s often creative duos and partnerships that fuel the engines of innovation.</span></p> <p><span style="font-weight: 400">In 2019, we launched the first cycle of Collaborative Pairs Project Awards, funding </span><a href="https://chanzuckerberg.com/science/programs-resources/neurodegeneration-challenge/projects/?award=collaborative-pairs-pilot-project" target="_blank" rel="noopener"><span style="font-weight: 400">30 teams</span></a><span style="font-weight: 400"> to </span><span style="font-weight: 400">explore innovative approaches addressing cross-cutting questions related to neurodegenerative disease biology. The application process was designed to encourage new teams and new ideas — no preliminary data, previous work together, or prior experience in neurodegeneration research was required to apply. We looked for talent, expertise, and great ideas. The first cohort of Collaborative Pairs working on 30 pilot projects included cell biologists, RNA biologists, neuroscientists, immunologis</span><span style="font-weight: 400">ts, cancer researchers, computer scientists, and even a plant biologist. Many of these investigators were new to neurodegeneration research. </span><span style="font-weight: 400">Sixteen of these projects have now moved forward to the second, four-year acceleration phase, where they are breaking new ground in unraveling the underlying mechanisms of neurodegenerative diseases. Learn more about the vision for the Collaborative Pairs Pilot Project Awards through this </span><a href="https://cziscience.medium.com/supporting-bold-and-transformative-ideas-in-neurodegeneration-47e69b4e215f?source=friends_link&sk=92f4e065dbe7e55091dfd4c3e7dde46c" target="_blank" rel="noopener"><span style="font-weight: 400">Medium post</span></a><span style="font-weight: 400"> and more information about the teams who were funded through Cycle 1 on our </span><a href="https://chanzuckerberg.com/science/programs-resources/neurodegeneration-challenge/projects/?award=collaborative-pairs-pilot-project" target="_blank" rel="noopener"><span style="font-weight: 400">website</span></a><span style="font-weight: 400">.</span></p> <p><span style="font-weight: 400">Building on the </span><a href="https://cziscience.medium.com/4-years-in-a-look-back-and-a-look-forward-for-the-neurodegeneration-challenge-network-4f68c5a34d3d?source=friends_link&sk=d86830f2719e0b677c0e89a4ed41702d" target="_blank" rel="noopener"><span style="font-weight: 400">successes of the Challenge Network</span></a><span style="font-weight: 400"> and the first cycle of Collaborative Pairs, we are now pleased to invite applications for a new Request for Applications (RFA) that supports Cycle 2 of the Collaborative Pairs Pilot Project Awards. For this new cycle of the Collaborative Pairs, we are excited to broaden the scope of our network to also support investigations into areas of fundamental neuroscience beyond neurodegenerative disease, in particular in areas where there is potential for complementarity or synergy with our existing work in the Neurodegeneration Challenge Network and/or other <a href="https://chanzuckerberg.com/science/programs-resources/" target="_blank" rel="noopener">CZ Science program areas</a></span><span style="font-weight: 400">. This expanded RFA scope includes basic investigations into the cellular, molecular and circuit mechanisms of memory and cognition and the neuroscience of sleep.</span></p> <p><span style="font-weight: 400">We are excited about this next chapter for the Challenge Network and neuroscience at CZI. With the view that a better understanding of the fundamental mechanisms of brain function in the healthy brain will also be critical for contextualizing the types of processes that go awry in neurodegenerative disease, we believe that this expanded neuroscience scope will allow us to continue to bring together innovative, cutting-edge scientists from across a range of disciplines to develop new ideas and approaches for tackling the many unsolved questions in neurodegenerative disease. And, likewise, we see tremendous opportunity for extending the Challenge Network approach and collaborative models to other areas of neuroscience.</span></p> <p><b>The Collaborative Pairs Pilot Project Awards (Cycle 2): </b></p> <p><span style="font-weight: 400">The Collaborative Pairs program will be a </span><b>two-phase process</b><span style="font-weight: 400">:</span></p> <p><b>Phase 1</b><span style="font-weight: 400"> of the Collaborative Pairs grants RFA will provide </span><b>seed funds for new interdisciplinary collaborations involving a pair of investigators and their labs to pursue a pilot project towards addressing a critical gap in the field</b><span style="font-weight: 400"> (see section on scope below). Each pair is required to include </span><b>at least one early or mid-career researcher</b><span style="font-weight: 400"> (less than 10 years in an independent academic PI role). </span><b>Collaborative Pairs projects will be funded for 18 months ($200,00 total costs/collaboration) for a pilot phase where teams will generate tools and data and further develop their project proposal and team, with the main goal being the development of a project plan for Phase 2. </b><span style="font-weight: 400">Funded teams will benefit from </span><span style="font-weight: 400">the support, mentoring and collaborative interactions of the Challenge Network, as well as interactions with the broader CZ Science programs and grantee network.</span></p> <p><span style="font-weight: 400">The purpose of the phase 1 Pilot Project Award is to give the collaborating teams the freedom to explore new, out-of-the-box, potentially transformative ideas. We are looking for </span><b>teams and proposals that are addressing a critical problem and doing so in a bold, innovative way. </b></p> <p><span style="font-weight: 400">In</span><b> Phase 2</b><span style="font-weight: 400">, Collaborative Pairs teams that received pilot project funding and have successfully progressed their project will be eligible to apply for an acceleration grant award </span><span style="font-weight: 400">of </span><b>$400,000 total costs/year/pair for four</b> <b>years ($1.6 million total) </b><span style="font-weight: 400">to build on the work done in the pilot phase</span><span style="font-weight: 400">,</span> <span style="font-weight: 400">for a</span><b> total of $1.8 million over five-and-a-half years for</b> <b>the entirety of the project (Phase 1 and Phase 2)</b><span style="font-weight: 400">.</span></p> <p><b>Scientific Scope</b></p> <p><span style="font-weight: 400">The Collaborative Pairs Pilot Project Awards RFA is focused on foundational and mechanistic basic science investigations. Building on and expanding from the successful foundations of the Neurodegeneration Challenge Network, applications may address fundamental questions related to the cellular, molecular or circuit mechanisms of neurodegenerative disease or areas of fundamental neuroscience beyond neurodegenerative disease. This expanded RFA scope includes basic investigations into the cellular, molecular and circuit mechanisms of memory and cognition and the neuroscience of sleep. We particularly encourage proposals where there is potential for complementarity or synergy with our existing work in the Neurodegeneration Challenge Network and/or other CZI program areas.</span></p> <p><span style="font-weight: 400">This is explicitly not a translational or clinical development RFA. Nonetheless, successful projects should be grounded in human biology, disease pathology, or fundamental principles of nervous system function such that the outputs of these efforts will ultimately provide new avenues and rigorous foundations for future translational and clinical development work.</span></p> <p><span style="font-weight: 400">We encourage applications both from investigators who are tackling underexplored topics, as well as those addressing more well-developed areas of science where there remain significant gaps in understanding. Pairings should take an innovative, interdisciplinary approach to address these knowledge gaps in ways that leverage each researcher’s unique, complementary area of expertise. For example, we’re looking for collaborative research projects that bring together experimentalists with computational biologists or technology developers, or collaborations that bridge multiple disciplines like immunology, cell biology, neurophysiology, genetics, biochemistry, stem cell biology, and bioengineering.</span></p> <p><span style="font-weight: 400">Examples of potential areas that would be </span><b>within scope for this program</b><span style="font-weight: 400"> include, but are not limited to:</span></p> <ul> <li><span style="font-weight: 400">Testing causal hypotheses for the role of circuit, cellular and molecular mechanisms in neurodegenerative disease pathogenesis across the lifespan.</span></li> <li><span style="font-weight: 400">Defining the contribution of non-neuronal influences on neurodegeneration or healthy brain function, including potential contributions of the innate and adaptive immune systems, brain vasculature, and the gut and microbiome to nervous system function.</span></li> <li><span style="font-weight: 400">Cellular- and systems-level approaches to studying neural plasticity, aging, and resilience in the context of neurodegenerative disease or healthy aging.</span></li> <li><span style="font-weight: 400">Investigating the causal contribution of well-defined cell types or circuits in cognitive processes or sleep-wake cycles.</span></li> <li><span style="font-weight: 400">Investigating interactions between central nervous system (CNS) sleep circuitry and fundamental cellular processes in peripheral organs and tissues of the body. </span></li> <li><span style="font-weight: 400">Partnerships between computational and experimental biologists that advance the development and validation of data analysis and data integration approaches, including but not limited to machine learning and artificial intelligence applications.</span></li> </ul> <p><span style="font-weight: 400">Examples of potential areas that would be </span><b>out of scope for this program</b><span style="font-weight: 400"> include:</span></p> <ul> <li><span style="font-weight: 400">Clinical research investigations involving human research participants and patients, including human neuroimaging studies.</span></li> <li><span style="font-weight: 400">Translational therapeutic or drug development research programs.</span></li> <li><span style="font-weight: 400">Fundamental investigations in nervous system disease or injury contexts outside of neurodegeneration, such as neurodevelopmental diseases or psychiatric disease.</span></li> </ul> <p><b>Building Tools to Support the Neurodegeneration Research Community</b></p> <p><span style="font-weight: 400">As part of the collective work of the Challenge Network, CZI asks investigators to contribute to the development, validation, and dissemination of robust, reliable, and scalable experimental and analytical tools for the broader research community. We particularly encourage applications that seek to develop, validate and disseminate new technologies and methodological approaches and of pairings of experimentalists and technology developers.</span></p> <p><span style="font-weight: 400">Examples of the types of tools and resources that Challenge Network grantees have contributed towards include: </span></p> <ul> <li><span style="font-weight: 400">Well-validated and reliable platforms for human cell biology, which might be based on tissue samples, iPSCs, organoids, or other advanced tissue biology systems.</span></li> <li><span style="font-weight: 400">Scalable tools for cellular analysis, including genomic, proteomic, and imaging methods optimized for human cells and relevance to neurodegeneration (for instance, targeted probes and label-free methods for cellular imaging of neurons and non-neuronal cells; robust affinity reagents for proteomics; genome editing and single-cell genomic approaches).</span></li> <li><span style="font-weight: 400">New tools to improve the specificity, resolution, and scale of cell-type and circuit targeting for phenotyping, monitoring, or manipulation. </span></li> <li><span style="font-weight: 400">Well-validated, robust, shared animal models that more accurately model human disease biology.</span></li> <li><span style="font-weight: 400">Unique human tissue resources and associated protocols for their handling and best use.</span></li> <li><span style="font-weight: 400">Rigorous benchmark datasets for the field, for instance, well-validated longitudinal studies of disease progression that will inform more mechanistic approaches.</span></li> <li><span style="font-weight: 400">Development and application of computational and machine learning approaches and tools to address neurodegeneration biology, which might include genomics, proteomics, metabolomics, systems biology, imaging, and/or integration of data across experimental models and scales.</span></li> </ul> <p><b>Diversity, Equity, & Inclusion</b></p> <ul> <li><span style="font-weight: 400">We </span><a href="https://chanzuckerberg.com/dei/#dei-funding" target="_blank" rel="noopener"><span style="font-weight: 400">believe</span></a><span style="font-weight: 400"> that the strongest teams incorporate a wide range of voices. Those underrepresented in science and technology are strongly encouraged to apply. This includes but is not limited to women, those with disabilities, underrepresented racial and ethnic groups, LGBTQIA+ individuals, and organizations representing disease areas that disproportionately impact underrepresented or underserved communities.</span></li> <li><span style="font-weight: 400">Researchers from populations that have historically been underrepresented in biomedical research are strongly encouraged to apply. International collaborations between investigators that leverage regional and technological expertise and strengths are encouraged. It is the expectation that international collaborations will follow </span><a href="https://www.nature.com/articles/s41559-021-01496-y" target="_blank" rel="noopener"><span style="font-weight: 400">guidelines</span></a><span style="font-weight: 400"> for conducting research in an equitable and mutually beneficial manner.</span></li> </ul> <p><b>Collaboration and Open Science</b></p> <p><span style="font-weight: 400">The CZI Neurodegeneration Challenge Network is an approach to address the scientific challenges of neurodegenerative diseases and an experiment in collaborative science. As part of the selection process, we will look for investigators and groups who will enthusiastically contribute to and benefit from a highly collaborative, dynamic, and interdisciplinary approach. For examples of evidence of productivity, reach, and collaboration, please see the </span><a href="https://chanzuckerberg.com/science/our-values-approach/" target="_blank" rel="noopener"><span style="font-weight: 400">CZI statement of values</span></a><span style="font-weight: 400">.</span></p> <ul> <li><span style="font-weight: 400">Investigators in the Challenge Network will have the opportunity to </span><b>learn from, collaborate with, and interact with the community of investigators and groups within the Network</b><span style="font-weight: 400">, as well as with Chan Zuckerberg Initiative scientists and software engineers. Investigators and members of their labs will participate in regular investigator meetings, meetings for students, postdocs, and staff, as well as mentorship and training opportunities. </span></li> <li><b>CZI’s mission is at the interface of technology and science.</b><span style="font-weight: 400"> Working in collaboration with, and guided by, Challenge Network investigators, we aim to develop technology-based tools and approaches to support and accelerate the broader field of neurodegeneration.</span></li> <li><b>Clinical partners in these collaborative projects will play important roles as mentors</b><span style="font-weight: 400"> to help the collective work of the Challenge Network stay closely aligned to the clinical contexts of these disorders and to the needs of patients. </span></li> <li><b>CZI supports open science values and principles</b><span style="font-weight: 400">. To accelerate scientific discovery, collaboration, and rapid dissemination, CZI supports a consent, sharing, and publication policy for open and rapid dissemination of research results and a policy for software development that maximizes accessibility, reuse, and shared development. </span></li> </ul> <p><b>Criteria we will be looking for in the Collaborative Pair Pilot Phase applications include:</b></p> <ul> <li><b>New collaborations</b><span style="font-weight: 400">: To be eligible, </span><b>proposed pairs cannot have received prior joint grant funding</b><span style="font-weight: 400">. Applicants will be asked to describe the nature of their collaboration and what unique perspective this pairing brings to the proposal. </span></li> <li><b>Multi-institutional pairings: </b><span style="font-weight: 400">While collaborations within a single institute are eligible to apply, we are especially encouraging of</span><b> new collaborations that bridge two distinct institutions</b><span style="font-weight: 400">. International collaborations are welcome and encouraged.</span></li> <li><b>Strong partnerships that leverage complementary strengths:</b><span style="font-weight: 400"> We will be looking for collaborations that bring together complementary, balanced skill sets and approaches. We strongly encourage applications from collaborations involving clinicians and physician-scientists, as well as pairs that bring together researchers from different fields, for instance: connecting experimental biologists and computational biologists; pairing technology developers with applied experimentalists; or bridging between multiple disciplines like immunology, cell biology, neuroscience, biochemistry, stem cell biology, and bioengineering.</span></li> <li><b>Bold, innovative, high-impact proposals</b><span style="font-weight: 400">: We are seeking proposals that address important, not incremental, problems in a creative way. This mechanism is an</span><b> opportunity to take well-calculated strategic risks</b><span style="font-weight: 400">. We expect that some collaborations will succeed, even if the pilot phase experiments fail and are encouraging of this kind of risk-taking science.</span></li> <li><b>Early- or mid-career investigators</b><span style="font-weight: 400">: Each pair must include at least one early- or mid-career researcher, someone who has been in an independent academic role for less than 10 years (see eligibility criteria for details).</span></li> <li><b>New investigators to the field</b><span style="font-weight: 400">: The scope of this RFA includes broader areas of neuroscience.</span><b> We continue to encourage applications with proposals that address fundamental challenges related to neurodegenerative diseases but applications are not required to focus on disease or neurodegeneration. </b><span style="font-weight: 400">There is no requirement to have worked in neurodegeneration research before and we encourage cross-over work from diverse disciplines.</span></li> <li><b>Diversity: </b><span style="font-weight: 400">We aspire to create a diverse community in the Challenge Network and </span><b>strongly encourage applications from women, those underrepresented or marginalized in science, and diverse groups worldwide.</b><span style="font-weight: 400"> See application instructions and eligibility criteria for specific details on eligibility.</span></li> <li><span style="font-weight: 400">The final determination of awards and numbers will depend on the quality of the applications received at CZI’s sole discretion.</span></li> </ul> </div> </div> </div> <div class="accordion accordion--half" accordion id="eligibility"> <div class="accordion__heading" accordion-heading tabindex="0"> <h5 class="t-h5--semibold">Eligibility</h5> <div class="accordion__icon"></div> </div> <div class="accordion__content" accordion-content> <div class="accordion__content-wrap"> <p><span style="font-weight: 400">All applications must be submitted by a primary applicant principal investigator (PI) on behalf of the pair. For questions about eligibility, please contact us in advance of the proposal deadline at </span><a href="mailto:sciencegrants@chanzuckerberg.com" target="_blank" rel="noopener"><span style="font-weight: 400">sciencegrants@chanzuckerberg.com</span></a><span style="font-weight: 400">.</span></p> <ul> <li><span style="font-weight: 400">Applications may be submitted by domestic and foreign non-profit organizations; public </span>and private institutions, such as colleges, universities, hospitals, laboratories, units of state and local governments; and eligible agencies of the federal government. For-profit organizations are not eligible. All grants will be awarded to institutions, not individuals.</li> <li><span style="font-weight: 400">Collaborations should include two principal investigators (PIs). There will be opportunities to work across collaborative projects, but each collaboration will be limited to two PIs. </span> <ul> <li><b>All applicants must hold a PhD, MD, or equivalent degree</b> <span style="font-weight: 400">and have an academic faculty position or equivalent independent investigator status at a college, university, medical school or other research facility. </span></li> <li><span style="font-weight: 400">Independence is typically demonstrated by a full-time academic faculty appointment, a tenure-track position, allocated space, a start-up package, and institutional commitment as defined or verified in a letter from a department chair or equivalent. </span><span style="font-weight: 400">Independence may be defined differently in different types of organizations.</span><span style="font-weight: 400"> Note: an upload of the letter or proof of independence is not required at the time of application.</span></li> </ul> </li> <li><b>The Collaborative Pairs RFA is aimed at motivating new collaborations among partners who have not yet had the opportunity to work together</b><span style="font-weight: 400">. While it is permissible for applicants to have previously worked together, the pair cannot have received joint funding for either this or any other project.</span></li> <li><span style="font-weight: 400">While collaborations among two principal investigators from the same institution are eligible, we </span><b>strongly encourage applications from pairs affiliated with different institutions </b><span style="font-weight: 400">(including any potential international collaborations).</span></li> <li><span style="font-weight: 400">Collaborations among pairs of investigators with prior mentor/mentee relationships at the graduate, post-doc, or junior faculty levels are strongly discouraged from applying. Examples may include pairings between a PI and their former graduate student or post-doc, or pairings between junior faculty and senior colleagues in the same department.</span></li> <li><span style="font-weight: 400">At least one of the applicants must be an early-career investigator or a mid-career investigator in an independent academic faculty position or equivalent.</span> <ul> <li><span style="font-weight: 400">In the context of this RFA, we are defining early-career investigators as individuals who have been in their independent academic faculty role for zero to six years at the time of the Letter of Intent due date, i.e. have </span><span style="font-weight: 400">started</span><span style="font-weight: 400"> their first independent position between June 22, 2017 and June 22, 2023.</span></li> <li><span style="font-weight: 400">A mid-career investigator is defined as in their faculty role for more than six years but not more than 10 years at the time of the Letter of Intent due date, i.e. have </span><span style="font-weight: 400">started</span><span style="font-weight: 400"> a first independent position between June 22, 2013 and June 21, 2017.</span></li> <li><span style="font-weight: 400">CZI will make exceptions to these criteria in cases of institutionally approved career breaks, e.g. family or medical leave, etc. (If you believe this applies to you, please contact </span><a href="mailto:sciencegrants@chanzuckerberg.com"><span style="font-weight: 400">sciencegrants@chanzuckerberg.com</span></a><span style="font-weight: 400">).</span></li> </ul> </li> <li><span style="font-weight: 400">Current NDCN Ben Barres Early Career Acceleration Award grantees and NDCN Collaborative Science grantees </span><b>are eligible to apply</b><span style="font-weight: 400">.</span></li> <li><span style="font-weight: 400">The following groups </span><b>are not eligible</b><span style="font-weight: 400"> to apply to this Collaborative Pairs RFA: </span> <ul> <li><span style="font-weight: 400">Investigators invited to submit full applications for the Ben Barres Early Career Acceleration Award (Cycle 2) RFA</span></li> <li><span style="font-weight: 400">Current NDCN Collaborative Pairs Phase 2 Investigators</span></li> <li><span style="font-weight: 400">Current Patient-Partnered Collaborations for Rare Neurodegenerative Disease Investigators</span></li> </ul> </li> <li><span style="font-weight: 400">The two PIs in the pair will </span><b>complete the online application together in the</b> <a href="https://apply.chanzuckerberg.com/" target="_blank" rel="noopener"><b>application portal</b></a><span style="font-weight: 400">,</span><span style="font-weight: 400"> but one PI should be designated as the Primary Applicant who will be responsible for submitting the application in the application portal. F</span><span style="font-weight: 400">unds will be</span> <span style="font-weight: 400">awarded directly to each PI’s institution, if selected for funding.</span></li> <li><span style="font-weight: 400">Applications are strongly encouraged from investigators new to the field of neurodegeneration, and, in particular, applications from researchers with relevant interdisciplinary training and experience in disciplines outside of neurodegeneration who bring new technology, resources, or frameworks to the field.</span></li> <li><span style="font-weight: 400">There may be more than one application from a given institution.</span></li> <li><span style="font-weight: 400">Each eligible investigator may only apply to one or be part of one Collaborative Pairs application.</span></li> <li><span style="font-weight: 400">We </span><a href="https://chanzuckerberg.com/about/our-approach/dei/" target="_blank" rel="noopener"><span style="font-weight: 400">believe</span></a><span style="font-weight: 400"> that the strongest teams incorporate a wide range of voices. Applications are strongly encouraged from women and those underrepresented or marginalized in science.</span></li> <li><span style="font-weight: 400">Meta employees, including employees of any subsidiary Meta entities, as well as employees of Chan Zuckerberg Initiative, LLC, are not permitted to apply.</span></li> <li><span style="font-weight: 400">CZI reserves the sole right to decide if an applicant and applicant organization meet the eligibility requirements.</span></li> <li><span style="font-weight: 400">CZI reserves the right to request budget changes prior to award.</span></li> <li><span style="font-weight: 400">Prior to award, all grant applications will be reviewed for compliance with the United States Treasury Department’s Office of Foreign Asset Control (OFAC) sanctions program, the United States Department of Commerce’s export administration regulations, the Foreign Corrupt Practices Act (FCPA), any other applicable U.S. laws and regulations, and any corresponding laws and regulations in the country where the applicant is based. All grant agreements will require the grantee to comply with these laws and regulations. For additional information, please refer to: the </span><a href="https://www.treasury.gov/resource-center/sanctions/Pages/default.aspx" target="_blank" rel="noopener"><span style="font-weight: 400">U.S. Treasury Department’s resources</span></a><span style="font-weight: 400">, the International Trade Administration’s </span><a href="https://www.trade.gov/us-export-controls" target="_blank" rel="noopener"><span style="font-weight: 400">website on US Export Controls</span></a><span style="font-weight: 400">, and the Department of Justice’s </span><a href="https://www.justice.gov/criminal-fraud/foreign-corrupt-practices-act" target="_blank" rel="noopener"><span style="font-weight: 400">website on the FCPA</span></a><span style="font-weight: 400">.</span></li> <li><span style="font-weight: 400">While applicants from all countries are welcome to apply, because of required ongoing compliance with U.S. sanctions and export controls, an applicant’s funding eligibility may need to be reassessed if the applicable laws and regulations change at any time. As a result, even if an applicant is eligible to receive funding at the time the application is reviewed, the applicant’s status may change later in the process or during the course of the grant term.</span></li> </ul> <p><span style="font-weight: 400">CZI suggests that you consult your home institution to determine eligibility to apply for this grant and your institutional policy on indirect costs. For questions about eligibility for this award or the application process, please contact us in advance of the proposal deadline at </span><a href="mailto:sciencegrants@chanzuckerberg.com"><span style="font-weight: 400">sciencegrants@chanzuckerberg.com</span></a><span style="font-weight: 400">. Deadline extensions will not be granted.</span></p> </div> </div> </div> <div class="accordion accordion--half" accordion id="application-requirements"> <div class="accordion__heading" accordion-heading tabindex="0"> <h5 class="t-h5--semibold">Application Requirements</h5> <div class="accordion__icon"></div> </div> <div class="accordion__content" accordion-content> <div class="accordion__content-wrap has-table"> <p><span style="font-weight: 400">The application for this Collaborative Pairs Pilot Project Awards RFA is a two-step process, initiated with a Letter of Intent (LOI). Letters of Intent will be evaluated, and finalists proceeding to the next stage of review will be notified by mid-August.</span></p> <div class="rfa-table-groups"> <div class="rfa-table"> <div class="rfa-table-row"> <div>Key Dates</div> <div></div> </div> <div class="rfa-table-row"> <div>May 9, 2023</div> <div>Letter of Intent (LOI) application portal opens</div> </div> <div class="rfa-table-row"> <div>June 22, 2023</div> <div>LOIs due by 5 P.M. (Pacific Time) due by 5 pm PT</div> </div> <div class="rfa-table-row"> <div>Mid-August 2023</div> <div>LOI decisions announced</div> </div> <div class="rfa-table-row"> <div></div> <div>Full application portal opens</div> </div> <div class="rfa-table-row"> <div>September 21, 2023</div> <div>Applications due by 5 P.M. (Pacific Time)</div> </div> <div class="rfa-table-row"> <div>January 2024</div> <div>Earliest notification of decisions (subject to change)</div> </div> <div class="rfa-table-row"> <div>March 1, 2024</div> <div>Expected start date of award period (subject to change)</div> </div> </div> </div> <ul> <li><b>Application specifics: </b> <ul> <li><b>Award Period: </b><span style="font-weight: 400">The award period is 18 months in duration with an expected project start date of March 1, 2024.</span></li> <li><b>Budget:</b><span style="font-weight: 400"> $200,000 total costs, inclusive of indirect costs ($100,000 total costs per collaborative pair investigator over 18 months, unless otherwise stated).</span></li> <li><b>Number of Principal Investigators/labs:</b> Two.</li> </ul> </li> <li><span style="font-weight: 400">One application should be submitted per collaborative pair. However, f</span><span style="font-weight: 400">unds will be awarded directly to each PI’s institution if selected for funding.</span></li> <li><span style="font-weight: 400">Institutional sign-off by the institutions of both PIs in the collaborative pair is required at the time of the LOI submission.</span></li> <li><span style="font-weight: 400">All applications must be completed and submitted through the Chan Zuckerberg Initiative’s online </span><a href="https://apply.chanzuckerberg.com" target="_blank" rel="noopener"><span style="font-weight: 400">grants management portal</span></a><span style="font-weight: 400">. It is recommended that applicants familiarize themselves with this portal well in advance of any deadlines.</span></li> </ul> </div> </div> </div> <div class="accordion accordion--half" accordion id="letter-of-intent-instructions"> <div class="accordion__heading" accordion-heading tabindex="0"> <h5 class="t-h5--semibold">Letter of Intent Instructions</h5> <div class="accordion__icon"></div> </div> <div class="accordion__content" accordion-content> <div class="accordion__content-wrap"> <p><span style="font-weight: 400">The Chan Zuckerberg Initiative uses SurveyMonkey Apply (SMApply) as its grants management portal. All applications must be submitted through this portal (</span><a href="https://apply.chanzuckerberg.com"><span style="font-weight: 400">https://apply.chanzuckerberg.com</span></a><span style="font-weight: 400">). SMApply is configured to work best using the Google Chrome browser. It is recommended that you familiarize yourself with this portal well in advance of any deadlines. Deadline extensions will not be granted.</span></p> <ul> <li><b>Application specifics: </b> <ul> <li><b>Eligibility: </b>Please refer to the <a href="https://chanzuckerberg.com/rfa/ndcn-collaborative-pairs#eligibility">Eligibility section</a> of this announcement.<span style="font-weight: 400"> </span></li> <li><b>Award Period: </b><span style="font-weight: 400">The award period </span><span style="font-weight: 400">is 18 months in duration</span><span style="font-weight: 400"> with an expected project start date of March 1, 2024.</span></li> <li><b>Budget: </b><span style="font-weight: 400">$200,000 total costs, inclusive of indirect costs ($100,000 total costs per collaborative pair investigator over 18 months, unless otherwise stated).</span></li> <li><b>Number of Principal Investigators/labs:</b> Two.</li> </ul> </li> <li><span style="font-weight: 400">One application should be submitted per collaborative pair. However, f</span><span style="font-weight: 400">unds will be awarded directly to each PI’s institution if selected for funding.</span></li> <li><span style="font-weight: 400">Institutional sign-off by the institutions of both PIs in the pair is required at the time of the LOI submission.</span></li> <li><span style="font-weight: 400">The application must be prepared in the grants portal by both principal investigators together in the collaborative pair, so please</span><b> designate one principal investigator (PI) as the primary applicant (“owner” in the portal), who should then invite the other PI to be a “collaborator” in the portal </b><span style="font-weight: 400">(see instructions for inviting application collaborators, listed below</span><span style="font-weight: 400">). The primary applicant is the PI in the pair who creates the application, invites the collaborating PI to be a “collaborator” on the application, and is responsible for submitting the application on behalf of the pair. It is expected that each PI will independently complete their designated Applicant Details, Equal Opportunity & Diversity, Organization Details, and Budget tasks within the portal and then collaborate to jointly complete the remaining tasks in the portal. </span><b>Once all tasks are complete, the primary applicant PI will need to click submit on behalf of the pair.</b></li> </ul> <p><b>Inviting application collaborators:</b></p> <p><span style="font-weight: 400">The application requires each of the collaborating principal investigators (PIs) to both complete their respective applicant details, organization details, and budget sections within the application portal. One PI should start the application in the portal (instructions below) and the second PI should be invited as a “collaborator” (instructions below). </span><b>Note: the applicant designated as the primary applicant (and the “owner” of the application in the portal) will be the only one who is able to submit the application on behalf of the collaborative pair.</b></p> <p><span style="font-weight: 400">Once an application has been created, complete the following steps to add your collaborating PI:</span></p> <ol> <li><span style="font-weight: 400">Click the </span><b>Add Collaborator </b><span style="font-weight: 400">button on the left side of the page on the initial application screen to invite your collaborating investigator, OR from within an application task marked as “Collaborator only task” click the </span><b>Add Collaborator</b><span style="font-weight: 400"> button.</span> <ol> <li><span style="font-weight: 400">Enter the email address of your collaborating PI in the first line.</span></li> <li><span style="font-weight: 400">By default the type of access should be set to “View & edit.” Do not change this option.</span></li> <li><span style="font-weight: 400">Add an optional message notifying your collaborating PI that they are invited to edit your application and should complete their portion.</span></li> <li><span style="font-weight: 400">Click the green Send Invite button in the bottom right corner.</span></li> <li><span style="font-weight: 400">To remove, resend invite, or change access, select the three dots next to the email address of the invited collaborator. Once a collaborator has registered and accepted, there is an option to change the primary applicant by selecting “Make Owner.”</span></li> </ol> </li> </ol> <p><b>The Letter of Intent (LOI) consists of the following sections (called tasks in the grants portal): </b><span style="font-weight: 400">Applicant Details, Equal Opportunity & Diversity, Organization Details, Biosketches, Pilot Project Details, and Research Statement.</span></p> <p><span style="font-weight: 400">The PIs of the collaborative pair are both responsible for filling out all relevant application sections. Each PI should complete the following sections independently: Applicant Details, Equal Opportunity & Diversity, Organization Details. The Biosketches, Pilot Project Details, and Research Statement sections should be completed jointly by both PIs.</span></p> <ul> <li><b>Principal Investigator 1 (PI #1):</b><span style="font-weight: 400"> The primary applicant is responsible for submitting the application on the team’s behalf and completing their individual tasks in addition to the collaborative project details and proposal.</span></li> <li><b>Principal Investigator 2 (PI #2):</b><span style="font-weight: 400"> The collaborating PI is responsible for completing their individual tasks in addition to the collaborative project details and proposal.</span></li> <li><b>Applicant Details (PI #1 & PI #2): </b><span style="font-weight: 400">Complete all fields in this task; all fields are required. The information entered should be for the primary applicant (Principal Investigator #1), who will be the person submitting the application on behalf of the pair. Information about the collaborating PI should be entered in the “Principal Investigator #2 (PI #2)” sections.</span> <ul> <li>Name and email <ul> <li>PI #1: (auto-filled for primary applicant): To edit your name or email, please do so in your account information by clicking your name in the upper right corner and clicking My Account in the dropdown menu.</li> <li>PI #2: Enter your First name, Last name, and Email</li> </ul> </li> <li>Degree(s).</li> <li>Organization, Title/Position, Department or equivalent.</li> <li>Career status: Select early-career (0 to 6 years), mid-career (6+ to 10 years), or neither. <ul> <li>Early-Career Definition: In the context of this RFA, an early-career investigator is someone who has been in an i<span style="font-weight: 400">ndependent position for zero to six years at the time of the Letter of Intent due date, i.e. has started their first independent position between June 22, 2017 and June 22, 2023.</span></li> <li><span style="font-weight: 400">Mid-Career Definition: In the context of this RFA, a mid-career investigator is someone who has been in an independent position for more than six but not more than 10 years at the time of the Letter of Intent due date, i.e. has started their first independent position between June 22, 2013 and June 21, 2017.</span></li> </ul> </li> <li><span style="font-weight: 400">ORCID iD: Enter in format XXXX-XXXX-XXXX-XXXX. ORCID iDs are unique, digital identifiers that distinguish individual scientists and unambiguously connect their contributions to science over time and across changes of name, location, and institutional affiliation. ORCID iDs will be used to streamline reporting in our applications and grant reports to reduce the burden on grantees. For more information, please visit <a href="https://orcid.org/register" target="_blank" rel="noopener">https://orcid.org/register</a>. (Please contact us at <a href="mailto:sciencegrants@chanzuckerberg.com">sciencegrants@chanzuckerberg.com</a> if you wish to opt out).</span></li> </ul> </li> <li><b>Equal Opportunity & Diversity (PI #1 & PI #2): </b><span style="font-weight: 400">CZI Science supports the science and technology that will make it possible to cure, prevent, or manage all diseases by the end of this century. Different communities are affected by or experience disease in different ways. Moreover, due to systemic barriers, the scientific enterprise itself is not a place where all voices and talents thrive. We believe the strongest scientific teams — encompassing ourselves, our grantees, and our partners — incorporate a wide range of backgrounds, lived experiences, and perspectives that guide them to the most important unsolved problems. To enable our work, we incorporate diverse perspectives into our strategy and processes, and we also seek to empower community partners to engage in science.</span><span style="font-weight: 400">We request demographic information associated with applications submitted to CZI in response to our open calls. This information helps us learn from the RFA process, as well as improve our strategies to help ensure members of underrepresented or marginalized groups in science are aware of and able to apply to CZI opportunities. <b>Please note that answering the questions below is voluntary and receiving funding is not contingent on providing this information. Demographic information provided may be used in our grant-making process, but will not be used as the sole or determinative factor in our grant funding decisions.</b> We may also publish aggregated data in various public forums, such as a website or blog. All responses will be shared only with limited personnel and service providers, who will use that information only for the purposes described in this paragraph. </span><span style="font-weight: 400">If you have any additional questions about why we ask this, what we do with the data, or to share suggestions for improvement, please reach out to <a href="mailto:sciencegrants@chanzuckerberg.com">sciencegrants@chanzuckerberg.com</a>.</span><span style="font-weight: 400">The information may be entered for the primary applicant (Principal Investigator #1), who will be the person submitting the application on behalf of the pair. Information about the collaborating PI may be entered in the “Principal Investigator #2 (PI #2)” sections.<br /> The categories listed below may not capture all possible identities; in the event that the categories do not accurately reflect your identities, please use the space provided to self describe.</span></p> <ul> <li><span style="font-weight: 400">What is your race/ethnicity? (optional)</span></li> <li><span style="font-weight: 400">What is the year of your last academic degree? (optional)</span></li> <li><span style="font-weight: 400">What is your gender? (optional)</span></li> <li><span style="font-weight: 400">Are you transgender? (optional)</span></li> <li><span style="font-weight: 400">Are you a member of the LGBTQIA+ community? (optional)</span></li> <li><span style="font-weight: 400">Do you have one or more disabilities? Please specify (optional)</span></li> </ul> </li> <li><b>Organization Details (PI #1 & PI #2):</b><span style="font-weight: 400"> Complete all fields in this task; all fields are required. The information entered should be for the organization of the applicable PI.</span> <ul> <li><span style="font-weight: 400">Organization name/Street address/City/State/Country/Website.</span></li> <li><span style="font-weight: 400">Type of Organization (Academic, Other Non-profit, Government, Other).</span></li> <li><span style="font-weight: 400">Tax ID: Enter your organization’s Employer Identification Number (EIN), as assigned by the Internal Revenue Service in the 9-digit format (XX-XXXXXXX; 10 characters total). Foreign organizations or others who do not have an EIN should enter 44-4444444. </span></li> <li><span style="font-weight: 400"><span style="text-decoration: underline">Organizational/Administrative Contact</span>:</span><span style="font-weight: 400"> List the name and contact information for the administrative contact to discuss additional information needed, if selected for award.</span> <ul> <li><span style="font-weight: 400">First name, Last name, Title/Position, Email.</span></li> </ul> </li> <li><span style="font-weight: 400"><span style="text-decoration: underline">Signing Official</span>:</span><span style="font-weight: 400"> List the name and contact information for the person authorized to sign on behalf of your organization.</span> <ul> <li><span style="font-weight: 400">First name, Last name, Title/Position, Email.</span></li> </ul> </li> <li><span style="font-weight: 400"><span style="text-decoration: underline">Press Contact / Public Relations Official</span>:</span><span style="font-weight: 400"> List the name and contact information for the person to discuss press releases and media.</span> <ul> <li><span style="font-weight: 400">First name, Last name, Title/Position, Email.</span></li> </ul> </li> <li><a href="https://apply.chanzuckerberg.com/protected/resource/eyJoZnJlIjogOTQ1ODEyNDksICJ2cSI6IDE2ODQ2Nn0/" target="_blank" rel="noopener"><span style="font-weight: 400">Institutional Approval Form</span></a><span style="font-weight: 400">: Upload as a single PDF. This </span><a href="https://apply.chanzuckerberg.com/protected/resource/eyJoZnJlIjogOTQ1ODEyNDksICJ2cSI6IDE2ODQ2Nn0/" target="_blank" rel="noopener"><span style="font-weight: 400">form</span></a><span style="font-weight: 400"> s</span><span style="font-weight: 400">hould be reviewed and signed by a person authorized to sign on behalf of your organization agreeing to the stated institutional and investigator requirements and commitments on data, resource sharing, and publication policies, as well as endorsing/verifying your application materials </span><span style="font-weight: 400">and confirming their ability to receive funding for the proposal. In the event of an award, funds will be awarded to the institutions of each PI in the pair as the prime institution, and those institutions will be responsible for ensuring compliance of all of the terms, including compliance of all partners/subcontract institutions. </span><b>These policies are non-negotiable so this form should only be signed if the organization is able to comply with the terms as stated. </b><span style="font-weight: 400">While CZI does not require sign-off by all of your partner institutions, please refer to what your institution requires. </span><b>Note: digital signatures are permitted as long as the document is not encrypted or password-protected.</b></li> </ul> </li> <li><b>Biosketches (PI #1, PI #2)</b><span style="font-weight: 400">: Upload the biosketches in PDF format for each PI in the Collaborative Pair. Biosketches can be uploaded in a combined PDF or one PDF for each PI; maximum of five pages per biosketch;</span><a href="https://grants.nih.gov/grants/forms/biosketch.htm" target="_blank" rel="noopener"> <span style="font-weight: 400">NIH</span></a> <span style="font-weight: 400">format or similar.</span></li> <li><b>Pilot Project Details:</b><span style="font-weight: 400"> Complete all fields in this task; all fields are required.</span> <ul> <li><span style="text-decoration: underline"><span style="font-weight: 400">Project Title</span></span><span style="font-weight: 400">: (maximum of 60 characters, including spaces) If you need to edit your project title, navigate to your application summary page, click on the three dots to the right of the application title (next to the Preview link) and select Rename from the dropdown menu.</span></li> <li><span style="text-decoration: underline"><span style="font-weight: 400">Project Purpose</span></span><span style="font-weight: 400">: (maximum of 200 characters, including spaces) </span><span style="font-weight: 400">Summarize your research project; limited to one sentence</span><span style="font-weight: 400">. Please use a third-person voice.</span> <ul> <li><span style="font-weight: 400">Example: T</span><span style="font-weight: 400">o leverage a CRISPR-based functional genomics platform in human iPSC-derived neurons and glia to elucidate cell-type selective and non-cell autonomous mechanisms of neurodegeneration</span></li> </ul> </li> <li><span style="text-decoration: underline"><span style="font-weight: 400">Statement on Diversity and Equity</span></span><span style="font-weight: 400">: </span><span style="font-weight: 400">(maximum of 250 words) </span><span style="font-weight: 400">Describe how your proposal and team seek to promote diversity and equity in this project. Examples can include your approach to diversity/equity on your team; diversity in the context of your scientific approach, for instance, engagement with diverse cohorts/populations; or a focus on diseases that are prevalent or overrepresented among populations living in high-potential countries that are historically under-resourced.</span></li> </ul> </li> <li><span style="text-decoration: underline"><b>Research Statement</b></span><b>: </b><span style="font-weight: 400">Upload a narrative statement of your research project in a single PDF; font must be 11 point or larger, and margins must be at least one-half inch (top, bottom, left, and right) for all pages. Include the following sections:</span> <ul> <li><b>Statement Body </b><span style="font-weight: 400">(maximum of 500 words) Address the following points: </span> <ul> <li><span style="font-weight: 400">Describe the question your proposed project is aiming to address and why this is an important gap in the field.</span></li> <li><span style="font-weight: 400">A high-level summary of your research plan for addressing the challenge/gap identified, highlighting in particular how your work stands out from other efforts in the field of neurodegeneration, sleep biology, and/or memory and cognition.</span></li> <li><span style="font-weight: 400">Highlight how the unique expertise of each PI in the pairing will enable progress toward addressing this scientific question through new collaborative efforts. </span></li> <li><span style="font-weight: 400">Highlight any innovative technologies and/or computational approaches your team will bring to the neurodegeneration, sleep biology, or memory and cognition research.</span></li> </ul> </li> <li><b>References Cited</b><span style="font-weight: 400"> in your research project (optional, one page limit): Provide PubMed links or DOIs where applicable; preprints are acceptable and should include the link to the preprint.</span></li> <li><b>Explanatory Figure</b><span style="font-weight: 400"> (optional): </span><span style="font-weight: 400">An explanatory figure of your research project may be included with an accompanying figure legend. If you choose to include an explanatory figure, the figure and figure legend must fit on one page. Figure legends do not count toward the word count.</span></li> </ul> </li> </ul> </div> </div> </div> <div class="accordion accordion--half" accordion id="full-application-instructions"> <div class="accordion__heading" accordion-heading tabindex="0"> <h5 class="t-h5--semibold">Full Application Instructions</h5> <div class="accordion__icon"></div> </div> <div class="accordion__content" accordion-content> <div class="accordion__content-wrap"> <p><b>Applicants will be notified by email if they have been invited to submit a full application by mid-August 2023.</b></p> <p><b>The Full Application will consist of the following additional sections (called tasks in the grants portal):</b> <span style="font-weight: 400">Biosketches, Project Details, Project Proposal, Budget Description.</span></p> <p><span style="font-weight: 400">The PIs of the collaborative pair are both responsible for filling out all relevant application sections. Each PI should complete the following sections independently: Biosketch and Budget Description. The Project Details and Project Proposal sections should be completed jointly by both PIs.</span></p> <ul> <li><b>Principal Investigator 1 (PI #1):</b><span style="font-weight: 400"> The primary applicant is responsible for submitting the application on the team’s behalf and completing their individual tasks in addition to the collaborative project details and proposal. </span><b>The primary applicant identified in the LOI should be the primary applicant for the full application.</b></li> <li><b>Principal Investigator 2 (PI #2):</b><span style="font-weight: 400"> The collaborating PI is responsible for completing their individual tasks in addition to the collaborative project details and proposal.</span></li> <li><b>Biosketches (PI #1, PI #2)</b><span style="font-weight: 400">: Upload the biosketch for each PI of the collaborative pair in PDF format. Applicants may upload either the same biosketch provided for the LOI or an updated version. Biosketches can be uploaded in a combined PDF or separate PDFs for each PI. Maximum of five pages per biosketch;</span><a href="https://grants.nih.gov/grants/forms/biosketch.htm" target="_blank" rel="noopener"> <span style="font-weight: 400">NIH format</span></a><span style="font-weight: 400"> or similar.</span></li> <li><b>Project Details:</b><span style="font-weight: 400"> Complete all fields in this task; all fields are required.</span> <ul> <li><span style="text-decoration: underline">Project Title</span><span style="font-weight: 400">: (maximum of 60 characters, including spaces) Auto-filled from LOI information. </span><b>This is not an editable section.</b></li> <li><span style="text-decoration: underline"><span style="font-weight: 400">Project Purpose</span></span><span style="font-weight: 400">: (maximum of 200 characters including spaces) Auto-filled from LOI information. </span><b>This is not an editable section.</b></li> <li><span style="text-decoration: underline"><span style="font-weight: 400">Abstract/Project Summary</span></span><span style="font-weight: 400">: </span><span style="font-weight: 400">(maximum of 250 words) Describe your project. Please use a third-person voice.</span></li> </ul> </li> <li><b>Project Proposal:</b><span style="font-weight: 400"> Upload your project proposal as a single PDF; font must be 11 point or larger, and margins must be at least one-half inch (top, bottom, left, and right) for all pages. Include the following sections:</span> <ul> <li><b>Proposal Body:</b> <span style="font-weight: 400">(maximum of 1500 words) </span><span style="font-weight: 400">Summary of the project, which should include the following parts:</span> <ul> <li><b>I. Scientific goals:</b><span style="font-weight: 400"> Define the scientific question or problem that the team aims to explore. Clarify the rationale for why it requires an interdisciplinary approach, why it has been historically difficult to address, and how the team is poised to clarify it.</span></li> <li><b>II. Deliverables and timeline:</b><span style="font-weight: 400"> In bulleted format describe the deliverables and timeline for deliverables.</span></li> <li><b>III. Research Outline: </b><span style="font-weight: 400">Describe the research proposed in the Pilot phase. </span><b>Note: No preliminary data is required for the pilot phase.</b></li> <li><b>IV. Transformative Research</b><span style="font-weight: 400">: (maximum of 150 words) Describe how your research is transformative for neurodegenerative disease, sleep or memory and cognition research. How do you see this work as standing out from other efforts in the field?</span></li> <li><b>V. Risk:</b> <span style="font-weight: 400">(maximum of 250 words) </span><span style="font-weight: 400">A goal of this grant mechanism is to encourage the pursuit of bold, potentially high impact but high-risk science.</span> <span style="font-weight: 400">What do you view as the riskiest parts of this project? Consider both conceptual and operational risks of the project. How are you planning to address these risks in your work?</span></li> <li><b>VI. Tools & Resources: </b><span style="font-weight: 400">Provide a summary of the tools, technology, and other resources that your team may bring to the project, aims to develop as a part of the project, and/or hopes to gain from collaborations in the Challenge Network. This list should highlight resources you can share with other projects and those that you feel you would benefit from having access to.</span></li> </ul> </li> <li><b>References Cited</b><span style="font-weight: 400"> in your proposal (no word/page limit).</span></li> <li><b>Figures </b><span style="font-weight: 400">(optional): </span><b>There is no requirement for preliminary data.</b><span style="font-weight: 400"> This RFA is intended to stimulate new collaborations and scientific directions. If you would like to provide figures of any kind, limit to one page, inclusive of legends. Figure legends do not count toward the word count.</span></li> </ul> </li> <li><b>Budget Description (PI #1 & PI #2): (one page maximum per PI) </b><span style="font-weight: 400">Upload a separate budget for each PI of the collaborative pair team in PDF format; font must be 11 point or larger and margins must be at least one-half inch (top, bottom, left, and right) for all pages (letter size required). Provide a high-level budget description in narrative or tabular form, outlining costs for personnel, supplies, equipment, travel, subcontracts, other and indirect costs.</span> <ul> <li><span style="font-weight: 400">The collaborative pair team will receive $200K total costs for 18 months, wherein the assumption is that the budget will be distributed evenly between the PIs (i.e. each PI will receive $100K total costs for 18 months). If the overall grant breakdown deviates from this assumption, please contact </span><a href="mailto:sciencegrants@chanzuckerberg.com"><span style="font-weight: 400">sciencegrants@chanzuckerberg.com</span></a><span style="font-weight: 400"> before submission.</span></li> <li><span style="font-weight: 400">Indirect costs are limited to up to 15 percent of direct costs. Indirect costs may not be assessed on capital equipment or subcontracts, but subcontractors may include up to 15% indirect costs of their direct costs.</span></li> <li><span style="font-weight: 400">Budget should be requested in U.S. dollars.</span></li> <li><span style="font-weight: 400">International grantees must use all grant funds exclusively for activities conducted outside the United States of America. Travel expenses to the U.S. (including round-trip tickets) should not be covered from the requested grant funds. Any attendance at CZI meetings in the U.S. will be covered by CZI outside of requested grant funds.</span></li> </ul> </li> </ul> <p><span style="font-weight: 400">The formatting and component requirements, including word and page limits indicated above, will be enforced by the review team. Any submitted materials that exceed the word and page limits or do not follow the requirements will not be considered during the application review process.</span></p> </div> </div> </div> <div class="accordion accordion--half" accordion id="selection-process"> <div class="accordion__heading" accordion-heading tabindex="0"> <h5 class="t-h5--semibold">Selection Process</h5> <div class="accordion__icon"></div> </div> <div class="accordion__content" accordion-content> <div class="accordion__content-wrap"> <p><span style="font-weight: 400">CZI will evaluate all applications for scientific merit and will seek independent expert review of applications. Final decisions will be made by CZI staff in consultation with our scientific advisors. CZI does not provide feedback on decisions for unfunded proposals. </span></p> <p><span style="font-weight: 400">The selection of awardees will be based on:</span></p> <ul> <li><span style="font-weight: 400">The scientific quality, creativity, and rigor of the proposed work. </span><b>We are looking for </b><b>innovative, bold, potentially transformative proposals</b>;</li> <li><span style="font-weight: 400">Demonstration that the proposal addresses a critical question or bottleneck for </span>neurodegenerative disease or fundamental neuroscience associated with sleep or memory and cognition biology;</li> <li><span style="font-weight: 400">The quality of the scientific team and the degree to which this collaboration leverages </span>complementary strengths;</li> <li><span style="font-weight: 400">The potential of the work to open up new research directions and/or bring new </span>approaches to critical problems in neurodegeneration research or fundamental neuroscience related to sleep, or memory and cognition;</li> <li><span style="font-weight: 400">The potential of the Collaborative Pairs and their teams to contribute to the collaborative, open science goals of the Neurodegeneration Challenge Network.</span></li> </ul> </div> </div> </div> <div class="accordion accordion--half" accordion id="policies"> <div class="accordion__heading" accordion-heading tabindex="0"> <h5 class="t-h5--semibold">Policies</h5> <div class="accordion__icon"></div> </div> <div class="accordion__content" accordion-content> <div class="accordion__content-wrap"> <ul> <li><span style="font-weight: 400">Funds from this award are intended to support research activities. Grants are made to </span>institutions on behalf of the named award recipients, and reasonable flexibility on how these funds are utilized is allowed, provided that the funds are used to support research activities related to the project. <b>A categorical budget for the 18-month grant period is required as part of the grant proposal at the time of the full application stage</b>. Funded investigators will be asked to provide summary budgets during annual reporting.</li> <li><span style="font-weight: 400">Specific deliverable requirements and due dates will be outlined in the award notification. Grantees of funded projects will be required to participate in regular meetings, including annual scientist meetings (which may be in person or virtual). Travel support for these meetings will be provided by CZI separately from the requested grant funds.</span></li> <li><span style="font-weight: 400">Grantees may obtain funds for their research from other funding sources, provided that </span>there is no conflict with meeting the terms of the CZI award.</li> </ul> <ul> <li><span style="font-weight: 400">Unused research funds may be carried over to the following year, and requests for no-cost extensions will be considered at the end of the overall project period and upon receipt of an annual report. </span></li> <li><span style="font-weight: 400">Indirect costs cannot exceed 15 percent of direct costs. Indirect costs may not be assessed on capital equipment or subcontracts, but subcontractors may include up to 15 percent indirect costs of their direct costs.</span></li> <li><span style="font-weight: 400">International grantees must use all grant funds exclusively for activities conducted outside the United States of America. Travel expenses to the United States must not be covered from the requested grant funds. </span></li> <li><b>Ethical conduct:</b><span style="font-weight: 400"> CZI advocates the highest standards for the ethical conduct of research. In addition to requirements of their own countries, grantees must adopt procedures for the use of animals in research and for the ethical treatment of human subjects and tissue donors, including obtaining their or their appropriate proxy’s written informed consent. CZI regards the policies of the National Institutes of Health as a strong model for such procedures.</span></li> <li><b>Data, publication, and dissemination policies:</b><span style="font-weight: 400"> To accelerate scientific discovery and collaboration, CZI supports a consent, sharing, and publication policy for open and rapid dissemination of research results, including methods, data and reagents, and a policy for software development that maximizes accessibility, reuse, and shared development. Under rare circumstances, exceptions to the above may be considered where there are specific situations that make meeting these goals impossible or counterproductive to the project.</span> <ul> <li><b>Software code:</b><span style="font-weight: 400"> CZI requires sharing of software code developed by its grantees generally to be made publicly available on GitHub (or a similar public service). All new code must be released under a permissive open source license (MIT, BSD 2-Clause, BSD 3-Clause, or Apache v2.0). All pre-existing and derivative code must be licensed under the most permissive license possible, given the licensing terms of the pre-existing code. All analysis packages must be released through the appropriate language-specific package manager (e.g., PyPi for Python, Bioconductor and CRAN for R) with documentation, example data, and interactive demos (e.g., Jupyter notebooks), and the use of Docker or similar container technologies to ensure portability and reproducibility. Software code supported by CZI must be archived for </span><a href="https://www.softwareheritage.org/archive/" target="_blank" rel="noopener"><span style="font-weight: 400">long-term digital preservation</span></a><span style="font-weight: 400"> and </span><a href="https://guides.github.com/activities/citable-code/" target="_blank" rel="noopener"><span style="font-weight: 400">citability</span></a><span style="font-weight: 400">, when applicable. </span></li> <li><b>Content and data sharing:</b><span style="font-weight: 400"> CZI is committed to developing and using platforms that disseminate data openly and freely. Any datasets either curated or generated through the proposal must be made as publicly available and easily accessible through an appropriate </span><a href="https://www.re3data.org/" target="_blank" rel="noopener"><span style="font-weight: 400">data repository</span></a><span style="font-weight: 400"> as legally permissible, when applicable, under an </span><a href="http://opendefinition.org/licenses/" target="_blank" rel="noopener"><span style="font-weight: 400">Open Definition conformant license</span></a><span style="font-weight: 400">. Ideally data sets would not include personally identifiable information, but if they do, consent to sharing the data must be obtained. Metadata, documentation, and intended use cases, as appropriate, must be made available under an Open Definition conformant license, preferably CC0 or CC BY/CC BY SA for content that requires explicit attribution.</span></li> <li><b>Publications:</b><span style="font-weight: 400"> To encourage rapid dissemination of results, any publications related to this funded work must be submitted to a preprint server (such as bioRxiv, medRxiv, arXiv, or any appropriate preprint repository), at or before the first submission to a journal. Experimental protocols should be made publicly available through a protocol sharing service, such as protocols.io. CZI requests that scientific publications, preprints, and presentations that result from this award acknowledge support from this funding. </span></li> <li><b>Reagent sharing:</b><span style="font-weight: 400"> Resources and reagents developed with this funding support must be available for rapid dissemination to the community, where possible in an accessible community repository, such as Addgene (for plasmids/DNA reagents/viruses) and Jackson Labs (for model systems lines), etc. This requirement applies to cell lines, transgenic organisms, plasmids/clones, antibodies, and other reagents.</span><span style="font-weight: 400"> </span></li> <li><b>Consent:</b><span style="font-weight: 400"> All human tissues must be adequately and fully consented to permit full sharing of the resulting data and any resulting tools, in accordance with laws and regulatory requirements, or other requirements. Any desired exceptions to this policy must be identified at the time of application, and such requests may affect the application’s chance of success. We are aware that there may be circumstances where broad consent may be challenging, and in some cases consent may be subject to revocation; we encourage investigators to discuss these cases with CZI scientific staff. </span><span style="font-weight: 400">As a reference, the Human Cell Atlas (HCA) community has developed </span><a href="https://www.humancellatlas.org/ethics/" target="_blank" rel="noopener"><span style="font-weight: 400">ethics guidelines and a tool kit</span></a><span style="font-weight: 400"> with template consent forms.</span></li> <li><b>Intellectual property rights:</b><span style="font-weight: 400"> CZI does not require assignment of ownership to any data, published results, or any other intellectual property that results from the work funded by these grants but will have the same rights generally granted to others. CZI supports and promotes policies that enable results and technologies to have the broadest reach and impact. To this end, all newly developed software must be made available through permissive open source licenses as described more fully above. Other technology and intellectual property rights (such as patents) must be made freely available for all academic and non-commercial use, and where intellectual property rights are commercialized, they must generally be subject to non-exclusive commercial licenses that enable broad availability and dissemination. </span></li> </ul> </li> </ul> <ul> <li><span style="font-weight: 400">Applications selected through this process will either be funded by the Chan Zuckerberg Initiative Foundation (CZIF) or recommended for funding through the Chan Zuckerberg Initiative Donor-Advised Fund (CZI DAF) at the Silicon Valley Community Foundation (SVCF).</span></li> </ul> </div> </div> </div> <div class="accordion accordion--half" accordion id="confidentiality"> <div class="accordion__heading" accordion-heading tabindex="0"> <h5 class="t-h5--semibold">Confidentiality</h5> <div class="accordion__icon"></div> </div> <div class="accordion__content" accordion-content> <div class="accordion__content-wrap"> <p><span style="font-weight: 400">All submitted applications will be kept confidential, except (1) as necessary for our evaluation or to comply with any applicable laws; and (2) to the extent that the application is made public or available to others without a duty of confidentiality through no fault of CZI. Notwithstanding, successfully funded proposals may be made publicly available and/or shared with other grantees or collaborators. Unfunded proposals will remain confidential as provided herein; however, information, including brief summaries of the proposed projects, project metrics, and the types of organizations that have applied for funding, may be made publicly available in aggregate form. Application materials will not be returned to applicants.</span></p> </div> </div> </div> </section> </div> </div> <div class="rfa__side desktop-only"> <div class="rfa__contact rfa__reference"> <div class="rfa__reference-inner"> <h5 class="rfa__reference-title">RFA Contact</h5> <div class="contact__paragraphs"> <p class="t-body--large"><span>For administrative and programmatic inquiries, or other questions pertaining to this RFA, please </span><span>contact </span><a href="mailto:sciencegrants@chanzuckerberg.com"><span>sciencegrants@chanzuckerberg.com</span></a><span>.</span> </p> </div> </div> </div> <div class="rfa__dates rfa__reference"> <div class="rfa__reference-inner"> <div class="rfa__reference-header"> <h5 class="rfa__reference-title">Key Dates</h5> </div> <div class="dates__list"> <div class="dates__date"> <div class="date__date">May 9, 2023</div> <div class="date__description t-body--large">Letter of Intent (LOI) application portal opens</div> </div> <div class="dates__date"> <div class="date__date">June 22, 2023</div> <div class="date__description t-body--large">LOIs due by 5 P.M. (Pacific Time)</div> </div> <div class="dates__date"> <div class="date__date">Mid-August 2023</div> <div class="date__description t-body--large">LOI decisions announced<br />Full application portal opens</div> </div> <div class="dates__date"> <div class="date__date">September 21, 2023</div> <div class="date__description t-body--large">Applications due by 5 P.M. (Pacific Time)</div> </div> <div class="dates__date"> <div class="date__date">January 2024</div> <div class="date__description t-body--large">Earliest notification of decisions (subject to change)</div> </div> <div class="dates__date"> <div class="date__date">March 1, 2024</div> <div class="date__description t-body--large">Expected start date of award period (subject to change)</div> </div> </div> <div class="dates__information"> <p class="t-body--large"><span>Award period and start date: Proposed projects should be 18 months in duration with a projected start date no earlier than March 1, 2024. Actual start date may vary.</span> </p> <p class="t-body--large"><strong>IMPORTANT DOCUMENTS</strong> </p> <p class="t-body--large"><a href="https://apply.chanzuckerberg.com/protected/r/FkmBTc_C-GJ6iD28zx8OmMjdxwM6qbz1XFuiwusn6cZ4-RtQsIF4fyppqdL_YJHr5w1j0AWL9r4AgoqkIkHxgQ==/NDCN_Collaborative_Pairs_Cycle_2_Instructions_revised_8_4_2023.pdf" target="_blank" rel="noopener">Application Instructions</a><br /> <a href="https://apply.chanzuckerberg.com/protected/resource/eyJoZnJlIjogOTQ1ODEyNDksICJ2cSI6IDE2ODQ2Nn0/" target="_blank" rel="noopener">Institutional Approval Form</a> </p> </div> </div> </div> </div> </div> <footer class="footer"> <div class="footer__header"> <div class="footer__logo t-h6--semibold"> <img src="https://chanzuckerberg.com/wp-content/themes/czi/img/logo-minified.svg" alt="Chan Zuckerberg Initiative logo"> <span>Building A Better Future for Everyone</span> </div> <div class="footer__socials desktop-only"> <p class="t-nav">Follow Us</p> <div> <a 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