The Use of Circulating Tumor DNA in Cancers of Unknown Prima

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The application of platinum-based chemotherapy is still rec..110391"/> <meta name="citation_publisher" content="Conseil m茅dical international en ligne" /> <meta name="citation_journal_title" content="Journal européen d'oncologie clinique"> <meta name="citation_title" content="The Use of Circulating Tumor DNA in Cancers of Unknown Primary: A Review of the Literature"> <meta name="citation_author" content="George Zarkavelis" /> <meta name="citation_author" content="Melina Yerolatsite" /> <meta name="citation_author" content="Nanteznta Torounidou" /> <meta name="citation_author" content="Anna-Lea Amylidi" /> <meta name="citation_author" content="Pinelopi Gogou" /> <meta name="citation_author" content="Athanasia Karavasili" /> <meta name="citation_author" content="Eleftherios Kampletsas" /> <meta name="citation_author" content="Davide Mauri" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="6"> <meta name="citation_issue" content="2"> <meta name="citation_abstract" content="Cancers of Unknown Primary (CUP) are not an uncommon clinical entity with high mortality rates. The application of platinum-based chemotherapy is still recommended as the Standard of Care (SOC) for patients with unfavorable CUP although with poor results. Attempts at identifying the primary tumor location with molecular assays have failed to show clinical benefit, while investigations of actionable targetable mutations are hampered by the significant molecular heterogeneity of CUP. Liquid biopsies, due to their inherent advantages such as being minimally invasive and allowing for the identification of temporal and spatial tumor heterogeneity, may provide an appealing alternative to elucidate the molecular background of CUP and tailor timely and individualized targeted and specific treatments. Although data are limited regarding the possible applications of circulating tumor DNA (ct-DNA) in CUP, they warrant further investigation."> <meta name="citation_abstract_html_url" content="https://french.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html"> </head> <body> <header>  <div class="bg-1"> <div class="container-fluid py-1"> <div class="row justify-content-between align-items-center"> <div class="col-sm-auto"> <a href="https://french.iomcworld.org/" title="IOMC"><img src="/assets/img/IOMC-logo-white.svg" alt="ejco" height="50" alt="IOMC"></a> </div> <div class="col-sm-auto"> <nav class="nav"> <a class="nav-link white"><i class="fa fa-whatsapp"></i> +44 7362049920 </a> <a href="mailto:oncology@scholarlymed.com" class="nav-link white"><i class="fas fa-envelope-square"></i> oncology@scholarlymed.com</a> <a href="https://www.scholarscentral.org/submissions/european-clinical-oncology.html" title="" class="btn bg-yellow-100">Soumettre le manuscrit</a>  <div class="nav-item dropdown multi_lang j_multi_lang"> <a class="nav-link dropdown-toggle" href="#" id="multi_lang" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Language </a> <div class="dropdown-menu" aria-labelledby=""> <a class="dropdown-item" href="https://www.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html" title="English"> <img src="https://www.longdom.org/admin/flags/usa.png">English </a> <a class="dropdown-item" href="https://spanish.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html" title="Spanish"> <img src="https://www.longdom.org/admin/flags/spain.png">Spanish </a> <a class="dropdown-item" href="https://chinese.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html" title="Chinese"> <img src="https://www.longdom.org/admin/flags/china.png">Chinese </a> <a class="dropdown-item" href="https://russian.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html" title="Russian"> <img src="https://www.longdom.org/admin/flags/russia.png">Russian </a> <a class="dropdown-item" href="https://german.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html" title="German"> <img src="https://www.longdom.org/admin/flags/germany.png">German </a> <a class="dropdown-item" href="https://japanese.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html" title="Japanese"> <img src="https://www.longdom.org/admin/flags/japan.png">Japanese </a> <a class="dropdown-item" href="https://portuguese.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html" title="Portuguese"> <img src="https://www.longdom.org/admin/flags/portugal.png">Portuguese </a> <a class="dropdown-item" href="https://hindi.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html" title="Hindi"> <img src="https://www.longdom.org/admin/flags/india.png">Hindi </a> <a class="dropdown-item" href="https://telugu.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html" title="Telugu"> <img src="https://www.longdom.org/admin/flags/india.png">Telugu </a> <a class="dropdown-item" href="https://tamil.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html" title="Tamil"> <img src="https://www.longdom.org/admin/flags/india.png">Tamil </a> </div> </div>  </nav> </div> </div> </div> </div>  <div class="py-3"> <div class="container-fluid"> <div class="row align-items-center justify-content-between"> <div class="col-12 col-sm-auto"> <h1 class="rockwell fweight-600 mb-0">Journal européen d'oncologie clinique</h1> <span class="float-right">ISSN - 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The application of platinum-based chemotherapy is still recommended as the Standard of Care (SOC) for patients with unfavorable CUP although with poor results. Attempts at identifying the primary tumor location with molecular assays have failed to show clinical benefit, while investigations of actionable targetable mutations are hampered by the significant molecular heterogeneity of CUP. Liquid biopsies, due to their inherent advantages such as being minimally invasive and allowing for the identification of temporal and spatial tumor heterogeneity, may provide an appealing alternative to elucidate the molecular background of CUP and tailor timely and individualized targeted and specific treatments. Although data are limited regarding the possible applications of circulating tumor DNA (ct-DNA) in CUP, they warrant further investigation.</p> </p> <div class="alert alert-info text-left"><b>Clause de non-responsabilit茅 :</b> Ce r茅sum茅 a 茅t茅 traduit 脿 l'aide d'outils d'intelligence artificielle et n'a pas encore 茅t茅 r茅vis茅 ou v茅rifi茅.</div> <div class="nav social-icons"> <a class="nav-link w-auto">Partagez cet article</a> <a title="" target="_blank" href="https://www.facebook.com/sharer.php?u=https://french.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="" target="_blank" href="https://twitter.com/share?url=https://french.iomcworld.org/abstract/the-use-of-circulating-tumor-dna-in-cancers-of-unknown-primary-a-review-of-the-literature-110391.html"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="" target="_blank" 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The Use of Circulating Tumor DNA in Cancers of Unknown Prima | 110391