Genetic testing identifies mutations known to cause inherited glaucoma

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According to Janey L. Wiggs, MD, PhD, genetic testing for early-onset forms of glaucoma can provide valuable diagnostic and prognostic information."/><meta id="metaKeywords" name="keywords" content="Ophthalmology,Ophthalmology,Glaucoma,Meeting News Coverage"/><meta id="Meta1" name="scID"/><meta id="scID" name="scID"/><meta name="PostedDate" content="2013-01-24"/> <meta name="ModifiedDate" content="2013-01-24"/> <meta name="specialties" content="Ophthalmology"/> <meta name="specialty" content="Ophthalmology"/> <meta name="primary_specialty" content="Ophthalmology"/> <meta name="subspecialties" content="Glaucoma"/> <meta name="subspecialty" content="Glaucoma"/> <meta name="primary_subspecialty" content="Glaucoma"/> <meta name="departments" content="Meeting News Coverage"/> <meta name="department" content="Meeting News Coverage"/> <meta name="content_type" content="News Article"/> <meta name="pageid" content="{035BC5FD-EE97-4109-8A1C-CB9319499E5D}"/> <meta property="og:image" 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id="greetingContainer2_divPartialReg"> <style type="text/css"> .linkNav { background: #f0f0f0; border: 1px solid #bdbdbd; color: #527091; padding: 5px; padding-left: 20px; } .linkNav a { color: #527091; text-decoration: none; cursor: pointer; } .ctaTextArea { position: absolute; width: 220px; bottom: 8px; left: 0px; font-weight: bold; text-align: center; } .ctaRegLink { position: relative; } </style> <script type="text/javascript"> //JS here $j(document).ready(function () { var showCta = false; var currentCTA = ''; if(showCta){ $j(".ctaImageLinkWrapper").click(function (event) { _gaq.push(['_trackEvent', 'Registration Process', 'CTA Click', currentCTA]); }); _gaq.push(['_trackEvent', 'Registration Process', 'CTA Load', currentCTA]); } }); </script> </div> <div id="greetingContainer2_divVisitor"> <style type="text/css"> .ctaShortRegForm { border: 2px solid #74b64a; background: #e7f3e0; } .shortRegTitle { background: #74b64a; color: White; padding: 3px; font-weight: bold; font-size: larger; } .shortRegForm { padding: 3px; position: relative; } .linkNav { background: #f0f0f0; border: 1px solid #bdbdbd; color: #527091; padding: 5px; padding-left: 20px; } .linkNav a { color: #527091; text-decoration: none; cursor: pointer; } /*Form Styling*/ .scfSectionContent .healioregform .scfValidator { position: absolute; top: 25px; left: 0; color: Red; width: 150px; height: 30px; overflow: hidden; background: #e7f3e0; } .scfSectionContent .healioregform:first-child .scfValidator { position: absolute; top: 55px; left: 0; color: Red; width: 150px; height: 30px; overflow: hidden; background: #e7f3e0; } .scfValidationSummary { position: absolute; top: 60px; left: 3px; color: Red; width: 150px; height: 30px; overflow: hidden; background: #e7f3e0; } .healioregform input.scfSingleLineTextBox { width: 150px !important; border: 1px solid #ccc !important; } .healioregform .scfSingleLineTextLabel { width: 30px !important; padding-bottom: 10px !important; padding-left: 10px !important; } .scfSubmitButtonBorder { text-align: right !important; } .healioregform { position: relative; clear: both; } .healioregform .scfRequired { position: absolute; left: 0px; width: 5px !important; } .ctaShortRegForm { height: 115px; } .scfSubmitButtonBorder { text-align: right !important; } </style> <script type="text/javascript"> //JS here $j(document).ready(function () { $j(".scfSubmitButton").attr("disabled","disabled"); var showModal = false; var smcookie = $j.cookie('hregshowthanks'); if(smcookie != null){ if(smcookie.length>0){ showModal = (smcookie == 'true'); } } var ctaValue = 'landingcta3'; if ($j.cookie('hregctaval') != null) { if ($j.cookie('hregctaval').length>0) { ctaValue = $j.cookie('hregctaval'); } } if(showModal){ $j(".fancybox").fancybox({afterClose:(function(){ $j.cookie('hregshowthanks','false',{expires:30,path:'/'});_gaq.push(['_trackEvent', 'Registration Process', 'CTA Form Modal Closed', ctaValue]);})}); $j(".fancybox").eq(0).trigger('click'); 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''){ ok=false; } }); if(ok){ $j.cookie('hregshowthanks','true',{expires:30,path:'/'}); _gaq.push(['_trackEvent', 'Registration Process', 'CTA Form Submit', ctaValue]); } else{ return false; } }); //make sure text box inputs have an original value set in data $j("input.scfSingleLineTextBox").each(function(){ if (!$j(this).data('originalValue')) { $j(this).data('originalValue', $j(this).val()); } }); //adjust user input $j('input.scfSingleLineTextBox').focus(function () { if (!$j(this).data('originalValue')) { $j(this).data('originalValue', $j(this).val()); } if ($j(this).val() == $j(this).data('originalValue')) { $j(this).val(''); } //simple validation $j(this).keyup(function(){ var ok = true; $j('input.scfSingleLineTextBox').each(function(){ if($j(this).val() == $j(this).data('originalValue') || $j(this).val() == ''){ $j(".scfSubmitButton").attr("disabled","disabled"); ok=false; } }); if(ok){ $j(".scfSubmitButton").removeAttr("disabled"); } }); }).blur(function () { $j(this).unbind('onkeyup') if ($j(this).val() == '') { $j(this).val($j(this).data('originalValue')); } }); } }); </script> <div id="greetingContainer2_ctlLanding_divCtaLandingContainer" class="ctaLandingContainer"> <div id="greetingContainer2_ctlLanding_divCtaImage" class="ctaImageLink"> <img src="/web/20131223082515im_/http://www.healio.com/~/media/Healio/thousandvids.jpg" alt="Register Now" width="220" height="112"/> </div> <div class="ctaShortRegForm" style="display: none;"> <div class="shortRegTitle"> Free Video Access</div> <div class="shortRegForm"> <div class="scfForm" id="form_83EA09863C65413F858E12608727AA3B"><input type="hidden" name="greetingContainer2$ctlLanding$form_83EA09863C65413F858E12608727AA3B$formreference" id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_formreference" value="form_83EA09863C65413F858E12608727AA3B"/><h1 id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_title" class="scfTitleBorder"> </h1> <div id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_intro" class="scfIntroBorder"> </div> <div id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_form_83EA09863C65413F858E12608727AA3B_submitSummary" class="scfSubmitSummary" style="color:Red;"> </div> <div id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_fieldContainer"> <div class="scfSectionBorder"> <div class="scfSectionBorder"> <div class="scfSectionContent"> <div id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_field_7AD0EC0F17284404BA069F2293CDF992_scope" class="healioregform fieldid.%7b7AD0EC0F-1728-4404-BA06-9F2293CDF992%7d name.Email predefinedValidator.A9F21BCD4C754A3486C7A2B3C19E04FF regex.%5e%5bA-Za-z0-9%5d((%5b_%5c.%5c-%5d%3f%5ba-zA-Z0-9%5d%2b)*)%40(%5bA-Za-z0-9%5d%2b)((%5b%5c.%5c-%5d%3f%5ba-zA-Z0-9%5d%2b)*)%5c.(%5bA-Za-z%5d%7b2%2c%7d)%24"> <label for="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_field_7AD0EC0F17284404BA069F2293CDF992" id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_field_7AD0EC0F17284404BA069F2293CDF992_text" class="scfSingleLineTextLabel">Email</label><div class="scfSingleLineGeneralPanel"> <input name="greetingContainer2$ctlLanding$form_83EA09863C65413F858E12608727AA3B$field_7AD0EC0F17284404BA069F2293CDF992" type="text" value="name@company.com" maxlength="256" id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_field_7AD0EC0F17284404BA069F2293CDF992" class="scfSingleLineTextBox"/><span class="scfSingleLineTextUsefulInfo" style="display:none;"></span> </div><span class="scfRequired">*</span> </div><div id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_field_B2904FADB734426E92175F7D6F87CA10_scope" class="healioregform fieldid.%7bB2904FAD-B734-426E-9217-5F7D6F87CA10%7d name.First+Name predefinedValidator.A9F21BCD4C754A3486C7A2B3C19E04FF regex.%5e%5ba-z+A-Z+%2c.%27-%5d%2b%24"> <label for="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_field_B2904FADB734426E92175F7D6F87CA10" id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_field_B2904FADB734426E92175F7D6F87CA10_text" class="scfSingleLineTextLabel">Name</label><div class="scfSingleLineGeneralPanel"> <input name="greetingContainer2$ctlLanding$form_83EA09863C65413F858E12608727AA3B$field_B2904FADB734426E92175F7D6F87CA10" type="text" value="Firstname Lastname" maxlength="100" id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_field_B2904FADB734426E92175F7D6F87CA10" class="scfSingleLineTextBox"/><span class="scfSingleLineTextUsefulInfo" style="display:none;"></span> </div><span class="scfRequired">*</span> </div> </div> </div> </div> </div> <div id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_footer" class="scfFooterBorder"> </div> <div class="scfSubmitButtonBorder"> <input type="submit" name="greetingContainer2$ctlLanding$form_83EA09863C65413F858E12608727AA3B$form_83EA09863C65413F858E12608727AA3B_submit" value="Submit" onclick="$scw.webform.lastSubmit = this.id;WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions("greetingContainer2$ctlLanding$form_83EA09863C65413F858E12608727AA3B$form_83EA09863C65413F858E12608727AA3B_submit", "", true, "form_83EA09863C65413F858E12608727AA3B_submit", "", false, false));$scw.webform.validators.setFocusToFirstNotValid('form_83EA09863C65413F858E12608727AA3B_submit')" id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_form_83EA09863C65413F858E12608727AA3B_submit" class="scfSubmitButton"/> </div> <input type="hidden" name="greetingContainer2$ctlLanding$form_83EA09863C65413F858E12608727AA3B$form_83EA09863C65413F858E12608727AA3B_eventcount" id="greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_form_83EA09863C65413F858E12608727AA3B_eventcount" value="1"/></div> </div> </div> <div class="linkNav"> <a id="greetingContainer2_ctlLanding_hyLogin" href="/web/20131223082515/http://www.healio.com/footer/account-information/login.aspx">Login</a>   |   <a id="greetingContainer2_ctlLanding_hyRegister" href="/web/20131223082515/http://www.healio.com/footer/account-information/welcome">Register</a> </div> </div> <a href="#formSubmitModal" class="fancybox"></a> <div id="formSubmitModal" style="display: none"> <a id="greetingContainer2_ctlLanding_hyThanksModal" class="hregThanksModalClick"></a> </div> </div> <div id="greetingContainer2_divValidationModal"> </div>  <script type="text/javascript"> $j(document).ready(function () { var value1 = $j('input:radio[name=scope]:checked').val(); var value2 = ""; $j("#search input#q").unbind(); $j("#search input#q").keypress(function (e) { var key = (window.event) ? window.event.keyCode : e.which; if (key == 13 && $j(this).val() != "") { $j("#btnG").click(); return false; } }); $j("input:radio[name=scope]").click(function () { value1 = $j(this).val(); //alert(value1); }); $j("#btnG").click(function () { var u = searchRoot + "/search?q=" + $j("#search input#q").val() + ((typeof (value1) === 'undefined' || value1 == "") ? "" : "&" + value1); window.location.replace(u); }); $j("#search input#q").focus(function () { $j("#search input#q").data("bg", $j("#search input#q").css('background')); $j("#search input#q").css('background', 'none') }).blur(function () { $j("#search input#q").css('background', $j("#search input#q").data("bg")) }); }); </script> <script language="javascript">var searchRoot='/ophthalmology';</script> <div id="search"> <input type="text" id="q" name="q"/> <input type="button" class="submit" name="btnG" id="btnG" value="Search"/>  <ul id="greetingContainer2_ctl01_Refiner" class="form-controls"> <li> <input type="radio" name="scope" value=""/>All Specialties</li> <li>  <input type="radio" name="scope" value="requiredfields=specialty:Ophthalmology" checked="checked"/>Ophthalmology</li> </ul>  </div>  </div>  </div>   <div id="menu">   <ul id="subspecialty-menu-b"> <li class="first"><a class="collapsed" style="display:none;">Subspecialties</a> <ul> <li><a href="/web/20131223082515/http://www.healio.com/ophthalmology" id="menu_0_anchorAll">All Ophthalmology</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/cataract-surgery"> Cataract Surgery</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/contact-lenses"> Contact Lenses</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/cornea-external-disease"> Cornea/External Disease</a></li> <li><a class="active " href="/web/20131223082515/http://www.healio.com/ophthalmology/glaucoma"> Glaucoma</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/imaging-diagnostics"> Imaging/Diagnostics</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/neurosciences"> Neurosciences</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/ocular-oncology"> Ocular Oncology</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/oculoplastics"> Oculoplastics</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/ophthalmic-business"> Ophthalmic Business</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/optics"> Optics</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/pediatrics-strabismus"> Pediatrics/Strabismus</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/practice-management"> Practice Management</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/refractive-surgery"> Refractive Surgery</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/regulatory-legislative"> Regulatory/Legislative</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/retina-vitreous"> Retina/Vitreous</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/ophthalmology/trauma"> Trauma</a></li> </ul> </li> </ul> <ul id="specialty-menu-a"> <li id="menu-a-healio-logo"> <a href="/web/20131223082515/http://www.healio.com/"><img src="https://web.archive.org/web/20131223082515im_/http://213a1ca8842e5e699a80-05ce35571e92a3f7383a191aa5840bba.r66.cf1.rackcdn.com/healio-specialty-menu-logo.png" alt="Healio" width="70" height="23"/></a> </li> <li> <h5 class="menu-head"> <a href="/web/20131223082515/http://www.healio.com/">All Specialties</a> </h5> </li> <li><a class="" href="/web/20131223082515/http://www.healio.com/adolescent-medicine"> Adolescent Medicine</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/allergy-immunology"> Allergy/Immunology</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/cardiology"> Cardiology</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/dermatology"> Dermatology</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/endocrinology"> Endocrinology</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/gastroenterology"> Gastroenterology</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/geriatric-medicine"> Geriatric Medicine</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/health-professions"> Health Professions</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/hematology-oncology"> Hematology/Oncology</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/hepatology"> Hepatology</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/infectious-disease"> Infectious Disease</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/nursing/journals"> Nursing</a></li> <li><a class="active " href="/web/20131223082515/http://www.healio.com/ophthalmology"> Ophthalmology</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/optometry"> Optometry</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/orthopedics"> Orthopedics</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/orthotics-prosthetics"> Orthotics/Prosthetics</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/pediatrics"> Pediatrics</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/psychiatry"> Psychiatry</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/rheumatology"> Rheumatology</a></li> <li><a class="" href="/web/20131223082515/http://www.healio.com/sports-medicine"> Sports Medicine</a></li> </ul> <div id="awardgroup"> <ul class="award-wrap"> <li class="col1"><a href="/web/20131223082515/http://www.healio.com/hematology-oncology/practice-management/news/online/%7Bbaa1a66a-8c99-4530-b5b2-4bd5946fd8c9%7D/healiocom-wins-2012-best-publishing-site-award" rel="nofollow">Sitecore Site of the Year</a></li> <li class="col2"><a href="/web/20131223082515/http://www.healio.com/news/online/%7B58FDC6A6-27D7-4AD3-8D3E-ED63D35F8BE2%7D/Healiocom-named-Medical-Marketing--Media-2013-award-finalist" rel="nofollow">Finalist - MMM Awards 2013</a></li> <li class="col3"><a href="/web/20131223082515/http://www.healio.com/news/online/%7BC15DEDA5-C675-417E-B896-80686B2C137C%7D/Healiocom-wins-2013-APEX-Grand-Award" rel="nofollow">Healio.com wins 2013 APEX Grand Award</a></li> </ul> </div> </div>   <div id="content-wrap">  <ul class="nav"> <li><a href="/web/20131223082515/http://www.healio.com/ophthalmology/news" title="News" target=""> News</a> <ul class="sub_menu"> <li class="first"> <a class="all" href="/web/20131223082515/http://www.healio.com/ophthalmology/news" title="News" target=""> All News</a> </li> <li class="first"> <a class="all" href="#" title="News" target=""> News Publications</a> </li> <li class=""> <a class="" 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<a href="/web/20131223082515/http://www.healio.com/ophthalmology/glaucoma"> Glaucoma</a> <span>›</span> <a href="/web/20131223082515/http://www.healio.com/ophthalmology/glaucoma/news"> News</a> </p>    <div id="SeeAlso" class="related-links"> <h3>See Also</h3> <ul><li><a href="https://web.archive.org/web/20131223082515/http://www.healio.com/ophthalmology/glaucoma/news/online/%7Ba65d3d85-a747-4b65-93f2-d113a2376e3b%7D/open-angle-glaucoma-patients-not-receiving-recommended-visual-field-tests">Open-angle glaucoma patients not receiving recommended ...</a></li><li><a href="https://web.archive.org/web/20131223082515/http://www.healio.com/ophthalmology/glaucoma/news/online/%7B71f7ad52-256e-4892-9374-e75e91144ffa%7D/glaucoma-implant-with-scleral-buckling-effective-for-glaucoma-retinal-detachment">Glaucoma implant with scleral buckling effective for glaucoma ...</a></li><li><a href="https://web.archive.org/web/20131223082515/http://www.healio.com/ophthalmology/glaucoma/news/online/%7B2acc03cc-280d-41a1-97f1-55f2d8920ac4%7D/malignant-glaucoma-responds-well-to-treatment-algorithm">Malignant glaucoma responds well to treatment algorithm ...</a></li></ul> </div>    <input name="layout_0$maincontent_0$seeAlsoInsertUnderParagraph" type="hidden" id="layout_0_maincontent_0_seeAlsoInsertUnderParagraph" value="1"/>  <div class="content"> <h2> Genetic testing identifies mutations known to cause inherited glaucoma</h2> <h3 class="deck"> </h3> <p class="main-subtitle"> </p> <div class="social-links-top"> <ul class="share"> <li class="l1"><a href="javascript:void(0)" class="facebook-link" target="_new">Facebook</a></li> <li class="l2"><a href="javascript:void(0)" class="twitter-link" target="_new">Tweet</a></li> <li class="l3"><a href="javascript:void(0)" class="linkedin-link">Share</a></li> </ul> </div> <ul class="meta-info"> <li> January 24, 2013</li> </ul> <div class="wyContent"> <p class="Bodytext1">WAIKOLOA, Hawaii — Genetic testing is available to identify mutations in genes known to cause dominant and recessive forms of inherited glaucoma, a speaker said here.</p> <p class="Bodytext">According to <strong>Janey L. Wiggs, MD, PhD,</strong> genetic testing for early-onset forms of <a href="https://web.archive.org/web/20131223082515/http://www.healio.com/ophthalmology/glaucoma" target="_blank">glaucoma</a> can provide valuable diagnostic and prognostic information.</p> <div class="mug right"><img alt="Janey L. Wiggs, MD, PhD" src="/web/20131223082515im_/http://www.healio.com/~/media/Images/News/Online/Ophthalmology/2013/01_Jan/Hawaii/Wiggs.jpg"/> <p class="name"><strong>Janey L. Wiggs</strong></p> </div> <p class="Bodytext">“For glaucoma, you really want to be able to treat people most effectively at the earliest stages of the disease,” she said at <a href="https://web.archive.org/web/20131223082515/http://www.healio.com/ophthalmology/meetings/meeting-news-coverage?setid={40116C3A-5302-4380-B957-D3F885A0EFE0}" target="_blank">Hawaiian Eye 2013</a>. “In addition to treatment tests, we can develop diagnostic tests, which will give [patients] a likely diagnosis, which is becoming increasingly important in terms of gene-based therapies. In some instances, we can also help establish a prognosis for a patient based on a specific gene mutation that they have.”</p> <p class="Bodytext">Currently, the genes <em>CYP1B1</em> and <em>LTBP2</em> can be tested for a prognosis of recessive <a href="https://web.archive.org/web/20131223082515/http://www.healio.com/ophthalmology/search.aspx?q=%22congenital+glaucoma%22&requiredfields=specialty:Ophthalmology&client=healio_frontend&output=xml_no_dtd&proxystylesheet=healio_frontendCME&site=healio-production&lr=lang_en&filter=p&getfields=*&ie=UTF-8&ip=192.168.100.144&access=p&entqr=3&oe=UTF-8&ud=1&sort=date%3AD%3AS%3Ad1" target="_blank">congenital glaucoma</a>; the <a href="https://web.archive.org/web/20131223082515/http://www.healio.com/ophthalmology/search.aspx?q=%22myocilin+gene%22&requiredfields=specialty:Ophthalmology&client=healio_frontend&output=xml_no_dtd&proxystylesheet=healio_frontendCME&site=healio-production&lr=lang_en&filter=p&getfields=*&ie=UTF-8&ip=192.168.100.144&access=p&entqr=3&oe=UTF-8&ud=1&sort=date%3AD%3AS%3Ad1" target="_blank">myocilin gene</a> can be tested for dominant open angle closure glaucoma; the genes <em>PITX2</em>, <em>FOXC1</em>, <em>LMX1B</em> and <em>PAX6</em> can be tested for Axenfeld-Rieger syndrome and aniridia; and the optineurin and <em>OPA1</em> genes can be tested for dominant familial normal tension glaucoma.</p> <p class="Bodytext">“Eventually, what we are looking forward to is a comprehensive gene panel that will tell us everything about a patient in regard to their glaucoma,” Wiggs said. “In today’s world, however, what we can test for are mutations in genes that are known to cause dominant and recessive forms of inherited glaucoma. The reason why we can do these and not the more common genetic risk factors is that these actually cause the disease, so we can give real information back to the patient and the physician.”</p> <p class="disclosure"><strong>Disclosure</strong>: Wiggs has no relevant financial disclosures.</p> </div>  <div class="fig left"> <p class="figcaption"> </p> </div> <div class="wyPagination">   </div>  <div class="follow"> <img src="/web/20131223082515im_/http://www.healio.com/~/media/Images/News/FollowUs.jpg" id="layout_0_maincontent_1_SocialFollow_socialfollow" name="socialfollow" alt="Follow us" usemap="#followus" border="0"/> <map id="followus" name="followus"> <area id="layout_0_maincontent_1_SocialFollow_followfb" shape="rect" coords="51,5,5,51" target="_blank" href="https://web.archive.org/web/20131223082515/http://www.facebook.com/ocularsurgerynews" alt="Follow us on Facebook"></area> <area id="layout_0_maincontent_1_SocialFollow_followtw" shape="rect" coords="270,3,320,50" target="_blank" href="https://web.archive.org/web/20131223082515/https://twitter.com/OSNSuperSite" alt="Follow us on Twitter"></area> </map> </div> </div>  <div class="social-links"> <div class="fb-like" data-send="false" data-width="300" data-show-faces="true" data-action="recommend"></div> <ul class="share"> <li><a href="javascript:void(0)" id="twitter" class="twitter-link" target="_new">Tweet</a></li> <li><a href="javascript:void(0)" id="facebook" class="facebook-link" target="_new">Share</a></li> <li class="linkedin"><a href="javascript:void(0)" id="linkedin" class="linkedin-link">Link</a></li> <li><span class="db-wrapper"><span class="g-plusone" data-size="tall" data-annotation="none"></span></span></li> <li><a href="javascript:void(0)" id="email">Email</a></li> <li class="last"><a href="javascript:void(0)" id="print">Print</a></li> </ul> <input name="layout_0$maincontent_1$SocialMedia$articleItemForTweet" type="hidden" id="layout_0_maincontent_1_SocialMedia_articleItemForTweet" value="{035BC5FD-EE97-4109-8A1C-CB9319499E5D}"/> <input name="layout_0$maincontent_1$SocialMedia$tweettext" type="hidden" id="layout_0_maincontent_1_SocialMedia_tweettext" class="tweettext" value="Genetic testing identifies mutations known to cause inherited glaucoma "/> <input name="layout_0$maincontent_1$SocialMedia$tweeturl" type="hidden" id="layout_0_maincontent_1_SocialMedia_tweeturl" class="tweeturl" value="http://goo.gl/RecMPB"/> </div>  <div id="respond"> <h4> Comments</h4> <script language="javascript" type="text/javascript"> var idcomments_acct = 'aa6ff53f9870e40f92f83e1b5df3cddf'; var idcomments_post_id = '{035BC5FD-EE97-4109-8A1C-CB9319499E5D}'; var idcomments_post_url; </script> <span id="IDCommentsPostTitle" style="display: none"></span> <script type="text/javascript" src="https://web.archive.org/web/20131223082515js_/http://www.intensedebate.com/js/genericCommentWrapperV2.js"></script> <p class="comment-notes"> Healio is intended for health care provider use and all comments will be posted at the discretion of the editors. 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Genetic testing identifies mutations known to cause inherited glaucoma | Ophthalmology