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KEGG PATHWAY: map00982
<!doctype html> <html><head> <title>KEGG PATHWAY: map00982</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1745453029"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1745453029"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1745453029" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « 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id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr3 w1"> <table width="650" class="w2"> <tr><th class="th30 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td30 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">map00982 Pathway <br> </span></code></td></tr></table></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td31 defd"><div class="cel">Drug metabolism - cytochrome P450</div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td30 defd"><div class="cel">Metabolism; Xenobiotics biodegradation and metabolism<br> <button class="btn" onclick="location.href='/brite/htext=ko00001.keg&query=ko00982';return false;">BRITE hierarchy</button></div></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Pathway map</span></th> <td class="td31 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map00982">map00982</a> </span></td><td>Drug metabolism - cytochrome P450</td></tr></table><center><a href="/pathway/map00982"><img src="/kegg/misc/thumbnail/map00982.gif" alt="map00982" style="border-style:none;"></a></center><br></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Kato R, Kamatari T (eds).</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">[Drug Metabolism] (In Japanese)</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Tokyo Kagaku Dojin (2000)</div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/16038189">16038189</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">J Chromatogr A 1082:6-14 (2005)<br>DOI:<a href="https://doi.org/10.1016/j.chroma.2005.01.004">10.1016/j.chroma.2005.01.004</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/18043895">18043895</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Breast Cancer Res Treat 107:15-24 (2008)<br>DOI:<a href="https://doi.org/10.1007/s10549-007-9526-7">10.1007/s10549-007-9526-7</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/16550168">16550168</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Rodriguez-Antona C, Ingelman-Sundberg M.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Cytochrome P450 pharmacogenetics and cancer.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Oncogene 25:1679-91 (2006)<br>DOI:<a href="https://doi.org/10.1038/sj.onc.1209377">10.1038/sj.onc.1209377</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/16393888">16393888</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Metabolism and transport of oxazaphosphorines and the clinical implications.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Drug Metab Rev 37:611-703 (2005)<br>DOI:<a href="https://doi.org/10.1080/03602530500364023">10.1080/03602530500364023</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/11226815">11226815</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Kosel M, Amey M, Aubert AC, Baumann P.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">In vitro metabolism of citalopram by monoamine oxidase B in human blood.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Eur Neuropsychopharmacol 11:75-8 (2001)<br>DOI:<a href="https://doi.org/10.1016/S0924-977X(00)00128-0">10.1016/S0924-977X(00)00128-0</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/10575324">10575324</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Olesen OV, Linnet K.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Pharmacology 59:298-309 (1999)<br>DOI:<a href="https://doi.org/10.1159/000028333">10.1159/000028333</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/9698084">9698084</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Biochem Pharmacol 56:15-23 (1998)<br>DOI:<a href="https://doi.org/10.1016/S0006-2952(98)00008-2">10.1016/S0006-2952(98)00008-2</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">David AW, Thomas LL, William OF.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Foye's Principles of Medicinal Chemistry (5th ed)</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Lippincott Williams & Wilkins (2002)</div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/11504799">11504799</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Oda Y, Kharasch ED.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">J Pharmacol Exp Ther 298:1021-32 (2001)</div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/10901707">10901707</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Drug Metab Dispos 28:959-65 (2000)</div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/12399158">12399158</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Mechanisms of idiosyncratic drug reactions: the case of felbamate.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Chem Biol Interact 142:99-117 (2002)<br>DOI:<a href="https://doi.org/10.1016/S0009-2797(02)00057-1">10.1016/S0009-2797(02)00057-1</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/18463198">18463198</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Drug Metab Dispos 36:1637-49 (2008)<br>DOI:<a href="https://doi.org/10.1124/dmd.107.019562">10.1124/dmd.107.019562</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/12386121">12386121</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Pearce RE, Vakkalagadda GR, Leeder JS.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Drug Metab Dispos 30:1170-9 (2002)<br>DOI:<a href="https://doi.org/10.1124/dmd.30.11.1170">10.1124/dmd.30.11.1170</a></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/10859160">10859160</a></div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Drug Metab Dispos 28:857-64 (2000)</div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td30 defd"></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td31 repd"><div class="cel">Bernad T, Joachim M.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td30 repd"><div class="cel">Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td31 repd"><div class="cel">Wiley-VCH (2003)</div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">KO pathway</span></th> <td class="td30 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/ko00982">ko00982</a> </span></td><td> </td></tr></table></td></tr> </table></td></tr></table> <br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>