Search results for: Grayanotoxins

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Grayanotoxins</title> <meta name="description" content="Search results for: Grayanotoxins"> <meta name="keywords" content="Grayanotoxins"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Grayanotoxins"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Grayanotoxins</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Contraction and Membrane Potential of C2C12 with GTXs</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bayan%20Almofty">Bayan Almofty</a>, <a href="https://publications.waset.org/abstracts/search?q=Yuto%20Yamaki"> Yuto Yamaki</a>, <a href="https://publications.waset.org/abstracts/search?q=Tadamasa%20Terai"> Tadamasa Terai</a>, <a href="https://publications.waset.org/abstracts/search?q=Sadahito%20Uto"> Sadahito Uto </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Culture techniques of skeletal muscle cells are advanced in the field of regenerative medicine and applied research of cultured muscle. As applied research of cultured muscle, myopathy (muscles disease) treatment is expected and development bio of actuator is also expected in biomedical engineering. Grayanotoxins (GTXs) is known as neurotoxins that enhance the permeability of cell membrane for Na ions. Grayanotoxins are extracted from a famous Pieris japonica and Ericaceae as well as a phytotoxin. In this study, we investigated the effect of GTXs on muscle cells (C2C12) contraction and membrane potential. Contraction of myotubes is induced by applied external electrical stimulation. Contraction and membrane potential change of skeletal muscle cells are induced by injection of current. We, therefore, concluded that effect of Grayanotoxins on contraction and membrane potential of C2C12 relate to acute toxicity of GTXs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=skeletal%20muscle%20cells%20C2C12" title="skeletal muscle cells C2C12">skeletal muscle cells C2C12</a>, <a href="https://publications.waset.org/abstracts/search?q=grayanotoxins" title=" grayanotoxins"> grayanotoxins</a>, <a href="https://publications.waset.org/abstracts/search?q=contraction" title=" contraction"> contraction</a>, <a href="https://publications.waset.org/abstracts/search?q=membrane%20potential" title=" membrane potential"> membrane potential</a>, <a href="https://publications.waset.org/abstracts/search?q=acute%20toxicity" title=" acute toxicity"> acute toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=pytotoxin" title=" pytotoxin"> pytotoxin</a>, <a href="https://publications.waset.org/abstracts/search?q=motubes" title=" motubes "> motubes </a> </p> <a href="https://publications.waset.org/abstracts/23536/contraction-and-membrane-potential-of-c2c12-with-gtxs" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23536.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">505</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Effect of Grayanotoxins on Skeletal Muscle Cell C2C12</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bayan%20Almofty">Bayan Almofty</a>, <a href="https://publications.waset.org/abstracts/search?q=Yuto%20Yamaki"> Yuto Yamaki</a>, <a href="https://publications.waset.org/abstracts/search?q=Tadamasa%20Terai"> Tadamasa Terai</a>, <a href="https://publications.waset.org/abstracts/search?q=Sadahito%20Uto"> Sadahito Uto</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Myopathy (muscles disease) treatment are expected in the field of regenerative medicine and applied research of cultured muscle to bio actuator is performed in Biomedical Engineering as applied research of cultured muscle. This study is about cultured myoblast C2C12 from mouse skeletal muscle and a mechanism of cultured muscle contraction by electric stimulation is investigated. Grayanotoxins (GTXs) belong to neurotoxins known to enhance the permeability of cell membrane for Na ions. Grayanotoxins are extracted from a famous Pieris japonica and Ericaceae as a phytotoxin. We investigated the functional role of GTXs on muscle cells (C2C12) contraction and membrane potential. A change in membrane potential is measured using a micro glass tube electrode contraction of myotubes is induced by applying an external electrical stimulation. The contraction and membrane potential change induced by injection of current using the micro glass electrode are also measured. From the result, contraction and membrane potential of muscle cells was affected by GTXs treatment, suggesting that the diverse chemical structures of GTXs are responsible for contraction and membrane potential of muscle cells. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=skeletal%20muscle" title="skeletal muscle">skeletal muscle</a>, <a href="https://publications.waset.org/abstracts/search?q=C2C12" title=" C2C12"> C2C12</a>, <a href="https://publications.waset.org/abstracts/search?q=myoblast" title=" myoblast"> myoblast</a>, <a href="https://publications.waset.org/abstracts/search?q=myotubes" title=" myotubes"> myotubes</a>, <a href="https://publications.waset.org/abstracts/search?q=contraction" title=" contraction"> contraction</a>, <a href="https://publications.waset.org/abstracts/search?q=Grayanotoxins" title=" Grayanotoxins"> Grayanotoxins</a>, <a href="https://publications.waset.org/abstracts/search?q=membrane%20potential" title=" membrane potential"> membrane potential</a>, <a href="https://publications.waset.org/abstracts/search?q=neurotoxins" title=" neurotoxins"> neurotoxins</a>, <a href="https://publications.waset.org/abstracts/search?q=phytotoxin" title=" phytotoxin"> phytotoxin</a> </p> <a href="https://publications.waset.org/abstracts/22503/effect-of-grayanotoxins-on-skeletal-muscle-cell-c2c12" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22503.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">468</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a 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Search results for: Grayanotoxins