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De esta manera afecto muchísimo a las capas más bajas de la sociedad, como la clase proletaria, produciendo una gran inflación. Este era un estado con ideologías neoliberalistas, el cual desprotegía la industria nacional que termino devastada a causa de la imposibilidad competitiva con la industria extranjera por cuestiones obvias de calidad. Además de los problemas económicos para la mayoría del pueblo, se estaba desarrollando un terrorismo de estado donde no había libertad de expresión y se vivía con temor debido a los militares y la etapa genocida que se estaba produciendo en Argentina. La cual se cometían crímenes, secuestros en manos de los militares, quienes poseían todo el poder y habían llegado allí a través de un golpe de estado. En cambio la URSS era un estado más inclusivo ya que en sus filas además de sus militares y empresarios poseían a los trabajadores es decir a la clase proletaria. Este poseía un desarrollo económico en conjunto a través de las diferentes capas sociales las cuales poseían un mismo objetivo, el crecimiento económico y bienestar social. Era</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/9078609" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="337b6f549b17bfddbe1dfeb330e1ddd8" rel="nofollow" data-download="{"attachment_id":35377547,"asset_id":9078609,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/35377547/download_file?st=MTc0MDM2MjQwMCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="20611707" href="https://uga.academia.edu/NadiaConti">Nadia Conti</a><script data-card-contents-for-user="20611707" type="text/json">{"id":20611707,"first_name":"Nadia","last_name":"Conti","domain_name":"uga","page_name":"NadiaConti","display_name":"Nadia Conti","profile_url":"https://uga.academia.edu/NadiaConti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_9078609 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="9078609"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 9078609, container: ".js-paper-rank-work_9078609", }); });</script></li><li class="js-percentile-work_9078609 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 9078609; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_9078609"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_9078609 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="9078609"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 9078609; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=9078609]").text(description); $(".js-view-count-work_9078609").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_9078609").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_9078616" data-work_id="9078616" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/9078616/Substituted_Indole2_carboxylates_as_Potent_Antagonists_of_the_Glycine_Binding_Site_Associated_with_the_NMDA_Receptor">Substituted Indole2-carboxylates as Potent Antagonists of the Glycine Binding Site Associated with the NMDA Receptor</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Arch. 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$(".js-view-count[data-work-id=9078616]").text(description); $(".js-view-count-work_9078616").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_9078616").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="9078616"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="84760" rel="nofollow" href="https://www.academia.edu/Documents/in/Mice">Mice</a>, <script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="712543" rel="nofollow" href="https://www.academia.edu/Documents/in/Glycine">Glycine</a>, <script data-card-contents-for-ri="712543" type="text/json">{"id":712543,"name":"Glycine","url":"https://www.academia.edu/Documents/in/Glycine","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="967839" rel="nofollow" href="https://www.academia.edu/Documents/in/Structure_activity_Relationship">Structure activity Relationship</a>, <script data-card-contents-for-ri="967839" type="text/json">{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1242506" rel="nofollow" href="https://www.academia.edu/Documents/in/Binding_Site">Binding Site</a><script data-card-contents-for-ri="1242506" type="text/json">{"id":1242506,"name":"Binding Site","url":"https://www.academia.edu/Documents/in/Binding_Site","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=9078616]'), work: {"id":9078616,"title":"Substituted Indole2-carboxylates as Potent Antagonists of the Glycine Binding Site Associated with the NMDA Receptor","created_at":"2014-11-02T06:18:28.593-08:00","owner_id":20611707,"url":"https://www.academia.edu/9078616/Substituted_Indole2_carboxylates_as_Potent_Antagonists_of_the_Glycine_Binding_Site_Associated_with_the_NMDA_Receptor","slug":"Substituted_Indole2_carboxylates_as_Potent_Antagonists_of_the_Glycine_Binding_Site_Associated_with_the_NMDA_Receptor","dom_id":"work_9078616","summary":"Arch. Pharm. Pharm. Med. 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In particular, the substitution of the para position of the terminal phenyl ring of GV150526 with suitable hydrophilic groups resulted in the identification of a new class of glycine antagonists. These compounds exhibited nanomolar in vitro affinity to the glycine binding site, high receptor selectivity, and outstanding in vivo potency. In particular, 3-[(E)-2-[(4-ureidomethylphenyl)aminocarbonyl]ethenyl]-4,6dichloroindole-2-carboxylic acid was found to be highly effective in the middle cerebral artery occlusion (MCAo) model in the rat, an animal model of focal ischemia, when given both prior to and after the occlusion of the middle cerebral artery. Notably, a significant neuroprotective effect was seen in this model postischamia, when the administration of this compound was delayed up to 6 h from the occlusion of the middle cerebral artery, further confirming the wide therapeutic window seen for GV150526A. * Corresponding</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/9078617" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5fd9143d667a7359b412e3602f14aa82" rel="nofollow" data-download="{"attachment_id":47894958,"asset_id":9078617,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47894958/download_file?st=MTc0MDM2MjQwMCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="20611707" href="https://uga.academia.edu/NadiaConti">Nadia Conti</a><script data-card-contents-for-user="20611707" type="text/json">{"id":20611707,"first_name":"Nadia","last_name":"Conti","domain_name":"uga","page_name":"NadiaConti","display_name":"Nadia Conti","profile_url":"https://uga.academia.edu/NadiaConti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_9078617 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="9078617"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 9078617, container: ".js-paper-rank-work_9078617", }); 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In particular, the substitution of the para position of the terminal phenyl ring of GV150526 with suitable hydrophilic groups resulted in the identification of a new class of glycine antagonists. These compounds exhibited nanomolar in vitro affinity to the glycine binding site, high receptor selectivity, and outstanding in vivo potency. In particular, 3-[(E)-2-[(4-ureidomethylphenyl)aminocarbonyl]ethenyl]-4,6dichloroindole-2-carboxylic acid was found to be highly effective in the middle cerebral artery occlusion (MCAo) model in the rat, an animal model of focal ischemia, when given both prior to and after the occlusion of the middle cerebral artery. Notably, a significant neuroprotective effect was seen in this model postischamia, when the administration of this compound was delayed up to 6 h from the occlusion of the middle cerebral artery, further confirming the wide therapeutic window seen for GV150526A. * Corresponding","publication":"Journal of Medicinal Chemistry","publication_with_fallback":"Journal of Medicinal 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Ischemia","url":"https://www.academia.edu/Documents/in/Cerebral_Ischemia"},{"id":712543,"name":"Glycine","url":"https://www.academia.edu/Documents/in/Glycine"},{"id":1010725,"name":"Protein Binding","url":"https://www.academia.edu/Documents/in/Protein_Binding"},{"id":1242506,"name":"Binding Site","url":"https://www.academia.edu/Documents/in/Binding_Site"},{"id":1685089,"name":"Cerebral Infarction","url":"https://www.academia.edu/Documents/in/Cerebral_Infarction"},{"id":1724844,"name":"Molecular Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure"},{"id":1953419,"name":"Neuroprotective Agents","url":"https://www.academia.edu/Documents/in/Neuroprotective_Agents"}],"publication_year":1999,"publication_year_with_fallback":1999,"paper_rank":null,"all_time_views":10,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_9078618" data-work_id="9078618" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/9078618/New_Synthesis_of_Substituted_2_Carboxyindole_Derivatives_Versatile_Introduction_of_a_Carbamoylethynyl_Moiety_at_the_C_3_Position">New Synthesis of Substituted 2-Carboxyindole Derivatives: Versatile Introduction of a Carbamoylethynyl Moiety at the C-3 Position</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Arch. 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