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значајних жена\u003C/a\u003E\u003C/b\u003E на Викицитату.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\n\u003Cdiv class=\"noticebanner\"\u003E\u003Cdiv class=\"plainlinks\" style=\"background-color: #FBEBEA; border-radius:5px; margin-top:10px; position:relative; border: 1px solid #aaa; font-family: \u0026#39;Helvetica\u0026#39;, \u0026#39;Arial\u0026#39;, sans-serif; line-height: 18px; box-shadow: 0 1px 1px rgba( 0, 0, 0, 0.15 ); overflow:hidden;\"\u003E\u003Cdiv style=\"display:block; top:4px; width:100%; text-align:center;;\"\u003E\u003Cdiv style=\"color:#000085; font-size:25px; line-height:25px\"\u003E\u003Cdiv style=\"padding-left:50px;\"\u003E\u003C/div\u003E\u003C/div\u003E\u003Cdiv style=\"padding-top:2px; color:#444; font-size:1.15em; line-height:1.5;\"\u003E\u003Cdiv style=\"padding-left:8px; padding-right:8px;\"\u003EПридружите се \u003Cb\u003E\u003Ca href=\"/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%90%D0%BA%D1%86%D0%B8%D1%98%D0%B0_%D0%BF%D1%80%D0%BE%D1%88%D0%B8%D1%80%D0%B8%D0%B2%D0%B0%D1%9A%D0%B0_%D0%BA%D0%BB%D0%B8%D1%86%D0%B0\" title=\"Википедија:Акција проширивања клица\"\u003Eакцији проширивања клица\u003C/a\u003E\u003C/b\u003E.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E";}}());</script></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Сајт"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Садржај" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" 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href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Literatura" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Literatura"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Literatura</span> </div> </a> <ul id="toc-Literatura-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Vidi_još" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Vidi_još"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Vidi još</span> </div> </a> <ul id="toc-Vidi_još-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Spoljašnje_veze" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Spoljašnje_veze"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Spoljašnje veze</span> </div> </a> <ul id="toc-Spoljašnje_veze-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Садржај" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Прикажи/сакриј садржај" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Прикажи/сакриј садржај</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Vezivanje za proteine plazme</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Чланак на другим језицима. Доступан на: 20" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-20" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">20 језика</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%B1%D8%A8%D8%B7_%D8%A8%D8%B1%D9%88%D8%AA%D9%8A%D9%86%D9%8A" title="ربط بروتيني — арапски" lang="ar" hreflang="ar" data-title="ربط بروتيني" data-language-autonym="العربية" data-language-local-name="арапски" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Ikatan_protein_plasma" title="Ikatan protein plasma — индонежански" lang="id" hreflang="id" data-title="Ikatan protein plasma" data-language-autonym="Bahasa Indonesia" data-language-local-name="индонежански" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Pengikatan_protein_plasma" title="Pengikatan protein plasma — малајски" lang="ms" hreflang="ms" data-title="Pengikatan protein plasma" data-language-autonym="Bahasa Melayu" data-language-local-name="малајски" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Uni%C3%B3_a_prote%C3%AFnes_plasm%C3%A0tiques" title="Unió a proteïnes plasmàtiques — каталонски" lang="ca" hreflang="ca" data-title="Unió a proteïnes plasmàtiques" data-language-autonym="Català" data-language-local-name="каталонски" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Proteinbindung" title="Proteinbindung — немачки" lang="de" hreflang="de" data-title="Proteinbindung" data-language-autonym="Deutsch" data-language-local-name="немачки" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Plasma_protein_binding" title="Plasma protein binding — енглески" lang="en" hreflang="en" data-title="Plasma protein binding" data-language-autonym="English" data-language-local-name="енглески" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Uni%C3%B3n_a_prote%C3%ADna_plasm%C3%A1tica" title="Unión a proteína plasmática — шпански" lang="es" hreflang="es" data-title="Unión a proteína plasmática" data-language-autonym="Español" data-language-local-name="шпански" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%BE%DB%8C%D9%88%D9%86%D8%AF_%D9%BE%D8%B1%D9%88%D8%AA%D8%A6%DB%8C%D9%86%DB%8C" title="پیوند پروتئینی — персијски" lang="fa" hreflang="fa" data-title="پیوند پروتئینی" data-language-autonym="فارسی" data-language-local-name="персијски" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Legame_dei_farmaci_alle_proteine_plasmatiche" title="Legame dei farmaci alle proteine plasmatiche — италијански" lang="it" hreflang="it" data-title="Legame dei farmaci alle proteine plasmatiche" data-language-autonym="Italiano" data-language-local-name="италијански" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E8%A1%80%E6%BC%BF%E3%82%BF%E3%83%B3%E3%83%91%E3%82%AF%E7%B5%90%E5%90%88" title="血漿タンパク結合 — јапански" lang="ja" hreflang="ja" data-title="血漿タンパク結合" data-language-autonym="日本語" data-language-local-name="јапански" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-mr mw-list-item"><a href="https://mr.wikipedia.org/wiki/%E0%A4%AA%E0%A5%8D%E0%A4%B0%E0%A4%A5%E0%A4%BF%E0%A4%A8%E0%A4%AC%E0%A4%82%E0%A4%A7%E0%A4%A4%E0%A4%BE" title="प्रथिनबंधता — марати" lang="mr" hreflang="mr" data-title="प्रथिनबंधता" data-language-autonym="मराठी" data-language-local-name="марати" class="interlanguage-link-target"><span>मराठी</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Plasma-eiwitbinding" title="Plasma-eiwitbinding — холандски" lang="nl" hreflang="nl" data-title="Plasma-eiwitbinding" data-language-autonym="Nederlands" data-language-local-name="холандски" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Liga%C3%A7%C3%A3o_a_prote%C3%ADnas_plasm%C3%A1ticas" title="Ligação a proteínas plasmáticas — португалски" lang="pt" hreflang="pt" data-title="Ligação a proteínas plasmáticas" data-language-autonym="Português" data-language-local-name="португалски" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A1%D0%B2%D1%8F%D0%B7%D1%8B%D0%B2%D0%B0%D0%BD%D0%B8%D0%B5_%D1%81_%D0%B1%D0%B5%D0%BB%D0%BA%D0%B0%D0%BC%D0%B8_%D0%BF%D0%BB%D0%B0%D0%B7%D0%BC%D1%8B" title="Связывание с белками плазмы — руски" lang="ru" hreflang="ru" data-title="Связывание с белками плазмы" data-language-autonym="Русский" data-language-local-name="руски" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Vezava_na_plazemske_beljakovine" title="Vezava na plazemske beljakovine — словеначки" lang="sl" hreflang="sl" data-title="Vezava na plazemske beljakovine" data-language-autonym="Slovenščina" data-language-local-name="словеначки" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Vezivanje_za_proteine_plazme" title="Vezivanje za proteine plazme — српскохрватски" lang="sh" hreflang="sh" data-title="Vezivanje za proteine plazme" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="српскохрватски" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Proteiinisitoutuminen_plasmassa" title="Proteiinisitoutuminen plasmassa — фински" lang="fi" hreflang="fi" data-title="Proteiinisitoutuminen plasmassa" data-language-autonym="Suomi" data-language-local-name="фински" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-tl mw-list-item"><a href="https://tl.wikipedia.org/wiki/Pagbubuklod_ng_plasma_ng_protina" title="Pagbubuklod ng plasma ng protina — тагалог" lang="tl" hreflang="tl" data-title="Pagbubuklod ng plasma ng protina" data-language-autonym="Tagalog" data-language-local-name="тагалог" class="interlanguage-link-target"><span>Tagalog</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Plazma_proteinine_ba%C4%9Flanma" title="Plazma proteinine bağlanma — турски" lang="tr" hreflang="tr" data-title="Plazma proteinine bağlanma" data-language-autonym="Türkçe" data-language-local-name="турски" 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class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">помери на страну</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">сакриј</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">С Википедије, слободне енциклопедије</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sr" dir="ltr"><p><b>Vezivanje za proteine <a href="/wiki/%D0%9A%D1%80%D0%B2%D0%BD%D0%B0_%D0%BF%D0%BB%D0%B0%D0%B7%D0%BC%D0%B0" title="Крвна плазма">krvne plazme</a></b> može da utiče na stepen efikasnosti leka. Lek koji je u manjoj meri vezan za proteine plazme može efikasnije da prolazi kroz ćelijsku membranu. Krvni proteini koji najčešće vezuju lekove su <a href="/wiki/%D0%90%D0%BB%D0%B1%D1%83%D0%BC%D0%B8%D0%BD" title="Албумин">albumin</a>, <a href="/wiki/Lipoprotein" title="Lipoprotein">lipoprotein</a>, <a href="/wiki/Glikoprotein" title="Glikoprotein">glikoprotein</a>, i α, β‚ i γ <a href="/wiki/Globulin" title="Globulin">globulini</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>Lek u krvi postoji u dva oblika: vezanom i nevezanom. U zavisnosti od specifičnog afiniteta leka za proteine plazme, jedan deo leka se može biti u vezanom obliku, dok je ostatak slobodan. Ako je vezivanje proteina reverzibilno, onda postoji <a href="/wiki/%D0%A5%D0%B5%D0%BC%D0%B8%D1%98%D1%81%D0%BA%D0%B0_%D1%80%D0%B0%D0%B2%D0%BD%D0%BE%D1%82%D0%B5%D0%B6%D0%B0" title="Хемијска равнотежа">hemijska ravnoteža</a> između vezanog i nevezanog stanja<sup id="cite_ref-Goodman_Gilman_2-0" class="reference"><a href="#cite_note-Goodman_Gilman-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>: </p> <dl><dd><i>Protein + lek ⇌ Protein-lek kompleks</i></dd></dl> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Vezivanje_za_proteine_plazme&veaction=edit&section=1" title="Уредите одељак „Reference”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Vezivanje_za_proteine_plazme&action=edit&section=1" title="Уреди извор одељка: Reference"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r28440201">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 30em;"> <ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><cite class="citation book">Shargel, Leon (2005). <i>Applied Biopharmaceutics & Pharmacokinetics</i>. New York: McGraw-Hill, Medical Pub. Division. <a href="/wiki/Me%C4%91unarodni_standardni_broj_knjige" title="Međunarodni standardni broj knjige">ISBN</a> <a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A8%D1%82%D0%B0%D0%BC%D0%BF%D0%B0%D0%BD%D0%B8_%D0%B8%D0%B7%D0%B2%D0%BE%D1%80%D0%B8/978-0-07-137550-4" title="Посебно:Штампани извори/978-0-07-137550-4">978-0-07-137550-4</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AVezivanje+za+proteine+plazme&rft.aufirst=Leon&rft.aulast=Shargel&rft.btitle=Applied+Biopharmaceutics+%26+Pharmacokinetics&rft.date=2005&rft.genre=book&rft.isbn=978-0-07-137550-4&rft.place=New+York&rft.pub=McGraw-Hill%2C+Medical+Pub.+Division&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-Goodman_Gilman-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-Goodman_Gilman_2-0">^</a></b></span> <span class="reference-text"><cite class="citation book">Hardman JG, Limbird LE, Gilman AG (2001). <a rel="nofollow" class="external text" href="http://books.mcgraw-hill.com/medical/goodmanandgilman/"><i>Goodman & Gilman's The Pharmacological Basis of Therapeutics</i></a> (10. изд.). New York: McGraw-Hill. <a href="/wiki/Me%C4%91unarodni_standardni_broj_knjige" title="Međunarodni standardni broj knjige">ISBN</a> <a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A8%D1%82%D0%B0%D0%BC%D0%BF%D0%B0%D0%BD%D0%B8_%D0%B8%D0%B7%D0%B2%D0%BE%D1%80%D0%B8/0071354697" title="Посебно:Штампани извори/0071354697">0071354697</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1036%2F0071422803">10.1036/0071422803</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AVezivanje+za+proteine+plazme&rft.au=Gilman%2C+AG&rft.au=Limbird%2C+LE&rft.aufirst=JG&rft.aulast=Hardman&rft.btitle=Goodman+%26+Gilman%27s+The+Pharmacological+Basis+of+Therapeutics&rft.date=2001&rft.edition=10.&rft.genre=book&rft.isbn=0071354697&rft.place=New+York&rft.pub=McGraw-Hill&rft_id=http%3A%2F%2Fbooks.mcgraw-hill.com%2Fmedical%2Fgoodmanandgilman%2F&rft_id=info%3Adoi%2F10.1036%2F0071422803&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Literatura">Literatura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Vezivanje_za_proteine_plazme&veaction=edit&section=2" title="Уредите одељак „Literatura”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Vezivanje_za_proteine_plazme&action=edit&section=2" title="Уреди извор одељка: Literatura"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><cite class="citation book">Shargel, Leon (2005). <i>Applied Biopharmaceutics & Pharmacokinetics</i>. New York: McGraw-Hill, Medical Pub. Division. <a href="/wiki/Me%C4%91unarodni_standardni_broj_knjige" title="Međunarodni standardni broj knjige">ISBN</a> <a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A8%D1%82%D0%B0%D0%BC%D0%BF%D0%B0%D0%BD%D0%B8_%D0%B8%D0%B7%D0%B2%D0%BE%D1%80%D0%B8/978-0-07-137550-4" title="Посебно:Штампани извори/978-0-07-137550-4">978-0-07-137550-4</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AVezivanje+za+proteine+plazme&rft.aufirst=Leon&rft.aulast=Shargel&rft.btitle=Applied+Biopharmaceutics+%26+Pharmacokinetics&rft.date=2005&rft.genre=book&rft.isbn=978-0-07-137550-4&rft.place=New+York&rft.pub=McGraw-Hill%2C+Medical+Pub.+Division&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span></li></ul> <div class="mw-heading mw-heading2"><h2 id="Vidi_još"><span id="Vidi_jo.C5.A1"></span>Vidi još</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a 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class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Vezivanje_za_proteine_plazme&action=edit&section=4" title="Уреди извор одељка: Spoljašnje veze"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://www.pubpk.org/index.php?title=Drug_Protein_Binding">Vezivanje lekova za proteine</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20110727192718/http://www.pubpk.org/index.php?title=Drug_Protein_Binding">Архивирано</a> на сајту <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a> (27. јул 2011)</li></ul> <div style="clear:both;"></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r25469611">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output 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title="Farmakokinetika">Farmakokinetika</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/%D0%90%D0%94%D0%9C%D0%95" class="mw-redirect" title="АДМЕ">ADME</a>: <a href="/wiki/Apsorpcija_(farmakokinetika)" title="Apsorpcija (farmakokinetika)">Apsorpcija</a> •  <a href="/wiki/Distribucija_(farmakologija)" title="Distribucija (farmakologija)">Distribucija</a> •  <a href="/wiki/Metabolizam_leka" class="mw-redirect" title="Metabolizam leka">Metabolizam</a> •  <a href="/wiki/%D0%95%D0%BA%D1%81%D0%BA%D1%80%D0%B5%D1%86%D0%B8%D1%98%D0%B0" class="mw-redirect" title="Екскреција">Ekskrecija</a> (<a href="/wiki/Uklanjanje_(medicina)" class="mw-redirect" title="Uklanjanje (medicina)">Uklanjanje</a>) <p><a href="/wiki/Po%C4%8Detna_doza" title="Početna doza">Početna doza</a> •  <a href="/wiki/Volumen_distribucije" title="Volumen distribucije">Volumen distribucije</a> (<a href="/wiki/Inicijalni_volumen_raspodele" class="mw-redirect" title="Inicijalni volumen raspodele">Inicijalni</a>) •  <a href="/wiki/Stopa_infuzije" title="Stopa infuzije">Stopa infuzije</a> </p><p><a href="/wiki/Pregrada_(farmakokinetika)" title="Pregrada (farmakokinetika)">Pregrada</a> •  <a href="/wiki/Bioekvivalentnost" title="Bioekvivalentnost">Bioekvivalentnost</a> •  <a href="/wiki/%D0%91%D0%B8%D0%BE%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B8%D0%B2%D0%BE%D1%81%D1%82" title="Биорасположивост">Biodostupnost</a> </p><p><a href="/wiki/Po%C4%8Detak_dejstva" title="Početak dejstva">Početak dejstva</a> •  <a href="/wiki/Poluvreme_eliminacije" title="Poluvreme eliminacije">Biološki polu-život</a> •  <a class="mw-selflink selflink">Vezivanje za proteine plazme</a> </p> <a href="/wiki/Terapeutski_indeks" title="Terapeutski indeks">Terapeutski indeks</a> (<a href="/wiki/%D0%9B%D0%B5%D1%82%D0%B0%D0%BB%D0%BD%D0%B0_%D0%B4%D0%BE%D0%B7%D0%B0" class="mw-redirect" title="Летална доза">LD<sub>50</sub></a>/<a href="/wiki/Efektivna_doza" title="Efektivna doza">ED<sub>50</sub></a>)</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Farmakodinamika" title="Farmakodinamika">Farmakodinamika</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/%D0%A2%D0%BE%D0%BA%D1%81%D0%B8%D1%87%D0%BD%D0%BE%D1%81%D1%82" title="Токсичност">Toksičnost</a> (<a href="/wiki/Neurotoksikologija" class="mw-redirect" title="Neurotoksikologija">Neurotoksikologija</a>) •  <a href="/wiki/Odnos_doza-efekat" class="mw-redirect" title="Odnos doza-efekat">Odnos doza-efekat</a> (<a href="/wiki/%D0%95%D1%84%D0%B8%D0%BA%D0%B0%D1%81%D0%BD%D0%BE%D1%81%D1%82" title="Ефикасност">Efikasnost</a>, <a href="/wiki/Potentnost_(farmakologija)" title="Potentnost (farmakologija)">Potentnost</a>)<br /> <a href="/wiki/Antimikrobna_farmakodinamika" title="Antimikrobna farmakodinamika">Antimikrobna farmakodinamika</a>: <a href="/wiki/Minimalna_inhibitorna_koncentracija" title="Minimalna inhibitorna koncentracija">Minimalna inhibitorna koncentracija</a>/<a href="/wiki/Bakteriostati%C4%8Dki_agens" title="Bakteriostatički agens">Bakteriostatik</a> •  <a href="/wiki/Minimalna_baktericidna_koncentracija" title="Minimalna baktericidna koncentracija">Minimalna baktericidna koncentracija</a>/<a href="/wiki/Baktericid" title="Baktericid">Baktericid</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Agonizam i antagonizam</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Agonist_(farmakologija)" title="Agonist (farmakologija)">Agonist</a>: <a href="/wiki/Inverzni_agonist" title="Inverzni agonist">Inverzni agonist</a> •  <a href="/wiki/Ireverzibilni_agonist" title="Ireverzibilni agonist">Ireverzibilni agonist</a> •  <a href="/wiki/Parcijalni_agonist" title="Parcijalni agonist">Parcijalni agonist</a> •  <a href="/wiki/Superagonist" title="Superagonist">Superagonist</a> •  <a href="/wiki/Fiziolo%C5%A1ki_agonizam_i_antagonizam" title="Fiziološki agonizam i antagonizam">Fiziološki agonist</a><br /> <p><a href="/wiki/Antagonist_(farmakologija)" title="Antagonist (farmakologija)">Antagonist</a>: <a href="/wiki/Kompetitivni_antagonist" title="Kompetitivni antagonist">Konkurentni antagonist</a> •  <a href="/wiki/Ireverzibilni_antagonist" title="Ireverzibilni antagonist">Ireverzibilni antagonist</a> •  <a href="/wiki/Fiziolo%C5%A1ki_agonizam_i_antagonizam" title="Fiziološki agonizam i antagonizam">Fiziološki antagonist</a> </p> Drugo: <a href="/wiki/Vezivanje_(molekulsko)" class="mw-redirect" title="Vezivanje (molekulsko)">Vezivanje</a> •  <a href="/wiki/Konstanta_disocijacije#Protein-ligand_vezivanje" title="Konstanta disocijacije">Afinitet</a> •  <a href="/wiki/Selektivnost_vezivanja" title="Selektivnost vezivanja">Selektivnost vezivanja</a> •  <a href="/wiki/Funkcionalna_selektivnost" title="Funkcionalna selektivnost">Funkcionalna selektivnost</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Drugo</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Tolerancija_leka" title="Tolerancija leka">Tolerancija leka</a>: <a href="/wiki/Tahifilaksija" title="Tahifilaksija">Tahifilaksija</a><br /> <a href="/wiki/Otpornost_na_lek" title="Otpornost na lek">Otpornost na lek</a>: <a href="/wiki/Otpornost_na_antibiotik" class="mw-redirect" title="Otpornost na antibiotik">Otpornost na antibiotik</a> •  <a href="/wiki/Otpornost_na_vi%C5%A1estruke_lekove" title="Otpornost na višestruke lekove">Otpornost na višestruke lekove</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Srodna polja/podpolja</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Farmakogenetika" title="Farmakogenetika">Farmakogenetika</a> •  <a href="/wiki/Farmakogenomika" title="Farmakogenomika">Farmakogenomika</a> •  <a href="/wiki/Neuropsihofarmakologija" title="Neuropsihofarmakologija">Neuropsihofarmakologija</a> (<a href="/wiki/Neurofarmakologija" title="Neurofarmakologija">Neurofarmakologija</a>, <a href="/wiki/%D0%9F%D1%81%D0%B8%D1%85%D0%BE%D1%84%D0%B0%D1%80%D0%BC%D0%B0%D0%BA%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%98%D0%B0" title="Психофармакологија">Psihofarmakologija</a>)</div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Преузето из „<a dir="ltr" href="https://sr.wikipedia.org/w/index.php?title=Vezivanje_za_proteine_plazme&oldid=26791602">https://sr.wikipedia.org/w/index.php?title=Vezivanje_za_proteine_plazme&oldid=26791602</a>”</div></div> <div id="catlinks" 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