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autocapitalize="sentences" title="Prohledat tuto wiki [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Speciální:Hledání"> </div> <button class="cdx-button cdx-search-input__end-button">Hledat</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Osobní nástroje"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Vzhled"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Změnit vzhled velikosti písma, šířky stránky a barvy" > 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class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_cs.wikipedia.org&uselang=cs" class=""><span>Podpořte Wikipedii</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Speci%C3%A1ln%C3%AD:Vytvo%C5%99it_%C3%BA%C4%8Det&returnto=Histidin" title="Doporučujeme vytvořit si účet a přihlásit se, ovšem není to povinné" class=""><span>Vytvoření účtu</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Speci%C3%A1ln%C3%AD:P%C5%99ihl%C3%A1sit&returnto=Histidin" title="Doporučujeme vám přihlásit se, ovšem není to povinné. [o]" accesskey="o" class=""><span>Přihlášení</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Další možnosti" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Osobní nástroje" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Osobní nástroje</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="Uživatelské menu" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_cs.wikipedia.org&uselang=cs"><span>Podpořte Wikipedii</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:Vytvo%C5%99it_%C3%BA%C4%8Det&returnto=Histidin" title="Doporučujeme vytvořit si účet a přihlásit se, ovšem není to povinné"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Vytvoření účtu</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:P%C5%99ihl%C3%A1sit&returnto=Histidin" title="Doporučujeme vám přihlásit se, ovšem není to povinné. [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Přihlášení</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Stránky pro odhlášené editory <a href="/wiki/N%C3%A1pov%C4%9Bda:%C3%9Avod" aria-label="Více informací o editování"><span>dozvědět se více</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:Moje_p%C5%99%C3%ADsp%C4%9Bvky" title="Seznam editací provedených z této IP adresy [y]" accesskey="y"><span>Příspěvky</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:Moje_diskuse" title="Diskuse o editacích provedených z této IP adresy [n]" accesskey="n"><span>Diskuse</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Projekt"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Obsah" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Obsah</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">přesunout do postranního panelu</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">skrýt</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">(úvod)</div> </a> </li> <li id="toc-Funkce_a_vlastnosti" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Funkce_a_vlastnosti"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Funkce a vlastnosti</span> </div> </a> <button aria-controls="toc-Funkce_a_vlastnosti-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Přepnout podsekci Funkce a vlastnosti</span> </button> <ul id="toc-Funkce_a_vlastnosti-sublist" class="vector-toc-list"> <li id="toc-Chemické_vlastnosti" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Chemické_vlastnosti"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Chemické vlastnosti</span> </div> </a> <ul id="toc-Chemické_vlastnosti-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Význam_v_proteinech" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Význam_v_proteinech"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.2</span> <span>Význam v proteinech</span> </div> </a> <ul id="toc-Význam_v_proteinech-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Další_využití" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Další_využití"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.3</span> <span>Další využití</span> </div> </a> <ul id="toc-Další_využití-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Posttranslační_modifikace" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Posttranslační_modifikace"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Posttranslační modifikace</span> </div> </a> <ul id="toc-Posttranslační_modifikace-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Zdroje" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Zdroje"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Zdroje</span> </div> </a> <ul id="toc-Zdroje-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Metabolismus" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Metabolismus"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Metabolismus</span> </div> </a> <button aria-controls="toc-Metabolismus-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Přepnout podsekci Metabolismus</span> </button> <ul id="toc-Metabolismus-sublist" class="vector-toc-list"> <li id="toc-Degradace" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Degradace"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Degradace</span> </div> </a> <ul id="toc-Degradace-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Odkazy" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Odkazy"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Odkazy</span> </div> </a> <button aria-controls="toc-Odkazy-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Přepnout podsekci Odkazy</span> </button> <ul id="toc-Odkazy-sublist" class="vector-toc-list"> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Externí_odkazy" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Externí_odkazy"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>Externí odkazy</span> </div> </a> <ul id="toc-Externí_odkazy-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Obsah" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Přepnout obsah" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Přepnout obsah</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Histidin</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Přejděte k článku v jiném jazyce. Je dostupný v 60 jazycích" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-60" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">60 jazyků</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%87%D8%B3%D8%AA%D9%8A%D8%AF%D9%8A%D9%86" title="هستيدين – arabština" lang="ar" hreflang="ar" data-title="هستيدين" data-language-autonym="العربية" data-language-local-name="arabština" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D9%87%DB%8C%D8%B3%D8%AA%DB%8C%D8%AF%DB%8C%D9%86" title="هیستیدین – South Azerbaijani" lang="azb" hreflang="azb" data-title="هیستیدین" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%93%D1%96%D1%81%D1%82%D1%8B%D0%B4%D1%8B%D0%BD" title="Гістыдын – běloruština" lang="be" hreflang="be" data-title="Гістыдын" data-language-autonym="Беларуская" data-language-local-name="běloruština" class="interlanguage-link-target"><span>Беларуская</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%A5%D0%B8%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Хистидин – bulharština" lang="bg" hreflang="bg" data-title="Хистидин" data-language-autonym="Български" data-language-local-name="bulharština" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Histidin" title="Histidin – bosenština" lang="bs" hreflang="bs" data-title="Histidin" data-language-autonym="Bosanski" data-language-local-name="bosenština" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Histidina" title="Histidina – katalánština" lang="ca" hreflang="ca" data-title="Histidina" data-language-autonym="Català" data-language-local-name="katalánština" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Histidin" title="Histidin – dánština" lang="da" hreflang="da" data-title="Histidin" data-language-autonym="Dansk" data-language-local-name="dánština" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Histidin" title="Histidin – němčina" lang="de" hreflang="de" data-title="Histidin" data-language-autonym="Deutsch" data-language-local-name="němčina" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%99%CF%83%CF%84%CE%B9%CE%B4%CE%AF%CE%BD%CE%B7" title="Ιστιδίνη – řečtina" lang="el" hreflang="el" data-title="Ιστιδίνη" data-language-autonym="Ελληνικά" data-language-local-name="řečtina" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Histidine" title="Histidine – angličtina" lang="en" hreflang="en" data-title="Histidine" data-language-autonym="English" data-language-local-name="angličtina" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Histidino" title="Histidino – esperanto" lang="eo" hreflang="eo" data-title="Histidino" data-language-autonym="Esperanto" data-language-local-name="esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Histidina" title="Histidina – španělština" lang="es" hreflang="es" data-title="Histidina" data-language-autonym="Español" data-language-local-name="španělština" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Histidiin" title="Histidiin – estonština" lang="et" hreflang="et" data-title="Histidiin" data-language-autonym="Eesti" data-language-local-name="estonština" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Histidina" title="Histidina – baskičtina" lang="eu" hreflang="eu" data-title="Histidina" data-language-autonym="Euskara" data-language-local-name="baskičtina" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%87%DB%8C%D8%B3%D8%AA%DB%8C%D8%AF%DB%8C%D9%86" title="هیستیدین – perština" lang="fa" hreflang="fa" data-title="هیستیدین" data-language-autonym="فارسی" data-language-local-name="perština" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Histidiini" title="Histidiini – finština" lang="fi" hreflang="fi" data-title="Histidiini" data-language-autonym="Suomi" data-language-local-name="finština" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Histidine" title="Histidine – francouzština" lang="fr" hreflang="fr" data-title="Histidine" data-language-autonym="Français" data-language-local-name="francouzština" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Histidina" title="Histidina – galicijština" lang="gl" hreflang="gl" data-title="Histidina" data-language-autonym="Galego" data-language-local-name="galicijština" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%94%D7%99%D7%A1%D7%98%D7%99%D7%93%D7%99%D7%9F" title="היסטידין – hebrejština" lang="he" hreflang="he" data-title="היסטידין" data-language-autonym="עברית" data-language-local-name="hebrejština" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%B9%E0%A4%BF%E0%A4%B8%E0%A5%8D%E0%A4%9F%E0%A4%BF%E0%A4%A1%E0%A4%BF%E0%A4%A8" title="हिस्टिडिन – hindština" lang="hi" hreflang="hi" data-title="हिस्टिडिन" data-language-autonym="हिन्दी" data-language-local-name="hindština" class="interlanguage-link-target"><span>हिन्दी</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Histidin" title="Histidin – chorvatština" lang="hr" hreflang="hr" data-title="Histidin" data-language-autonym="Hrvatski" data-language-local-name="chorvatština" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Hisztidin" title="Hisztidin – maďarština" lang="hu" hreflang="hu" data-title="Hisztidin" data-language-autonym="Magyar" data-language-local-name="maďarština" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%80%D5%AB%D5%BD%D5%BF%D5%AB%D5%A4%D5%AB%D5%B6" title="Հիստիդին – arménština" lang="hy" hreflang="hy" data-title="Հիստիդին" data-language-autonym="Հայերեն" data-language-local-name="arménština" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Histidina" title="Histidina – indonéština" lang="id" hreflang="id" data-title="Histidina" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonéština" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Istidina" title="Istidina – italština" lang="it" hreflang="it" data-title="Istidina" data-language-autonym="Italiano" data-language-local-name="italština" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%92%E3%82%B9%E3%83%81%E3%82%B8%E3%83%B3" title="ヒスチジン – japonština" lang="ja" hreflang="ja" data-title="ヒスチジン" data-language-autonym="日本語" data-language-local-name="japonština" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ka mw-list-item"><a href="https://ka.wikipedia.org/wiki/%E1%83%B0%E1%83%98%E1%83%A1%E1%83%A2%E1%83%98%E1%83%93%E1%83%98%E1%83%9C%E1%83%98" title="ჰისტიდინი – gruzínština" lang="ka" hreflang="ka" data-title="ჰისტიდინი" data-language-autonym="ქართული" data-language-local-name="gruzínština" class="interlanguage-link-target"><span>ქართული</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%93%D0%B8%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Гистидин – kazaština" lang="kk" hreflang="kk" data-title="Гистидин" data-language-autonym="Қазақша" data-language-local-name="kazaština" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%ED%9E%88%EC%8A%A4%ED%8B%B0%EB%94%98" title="히스티딘 – korejština" lang="ko" hreflang="ko" data-title="히스티딘" data-language-autonym="한국어" data-language-local-name="korejština" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-lb mw-list-item"><a href="https://lb.wikipedia.org/wiki/Histidin" title="Histidin – lucemburština" lang="lb" hreflang="lb" data-title="Histidin" data-language-autonym="Lëtzebuergesch" data-language-local-name="lucemburština" class="interlanguage-link-target"><span>Lëtzebuergesch</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Histidinas" title="Histidinas – litevština" lang="lt" hreflang="lt" data-title="Histidinas" data-language-autonym="Lietuvių" data-language-local-name="litevština" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Histid%C4%ABns" title="Histidīns – lotyština" lang="lv" hreflang="lv" data-title="Histidīns" data-language-autonym="Latviešu" data-language-local-name="lotyština" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%A5%D0%B8%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Хистидин – makedonština" lang="mk" hreflang="mk" data-title="Хистидин" data-language-autonym="Македонски" data-language-local-name="makedonština" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Histidina" title="Histidina – malajština" lang="ms" hreflang="ms" data-title="Histidina" data-language-autonym="Bahasa Melayu" data-language-local-name="malajština" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Histidine" title="Histidine – nizozemština" lang="nl" hreflang="nl" data-title="Histidine" data-language-autonym="Nederlands" data-language-local-name="nizozemština" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Histidin" title="Histidin – norština (nynorsk)" lang="nn" hreflang="nn" data-title="Histidin" data-language-autonym="Norsk nynorsk" data-language-local-name="norština (nynorsk)" class="interlanguage-link-target"><span>Norsk nynorsk</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Histidin" title="Histidin – norština (bokmål)" lang="nb" hreflang="nb" data-title="Histidin" data-language-autonym="Norsk bokmål" data-language-local-name="norština (bokmål)" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/Istidina" title="Istidina – okcitánština" lang="oc" hreflang="oc" data-title="Istidina" data-language-autonym="Occitan" data-language-local-name="okcitánština" class="interlanguage-link-target"><span>Occitan</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Histydyna" title="Histydyna – polština" lang="pl" hreflang="pl" data-title="Histydyna" data-language-autonym="Polski" data-language-local-name="polština" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-ps mw-list-item"><a href="https://ps.wikipedia.org/wiki/%D9%87%D8%B3%D9%BC%D8%A7%D9%8A%DA%89%D9%8A%D9%86" title="هسټايډين – paštština" lang="ps" hreflang="ps" data-title="هسټايډين" data-language-autonym="پښتو" data-language-local-name="paštština" class="interlanguage-link-target"><span>پښتو</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Histidina" title="Histidina – portugalština" lang="pt" hreflang="pt" data-title="Histidina" data-language-autonym="Português" data-language-local-name="portugalština" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Histidin%C4%83" title="Histidină – rumunština" lang="ro" hreflang="ro" data-title="Histidină" data-language-autonym="Română" data-language-local-name="rumunština" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%93%D0%B8%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Гистидин – ruština" lang="ru" hreflang="ru" data-title="Гистидин" data-language-autonym="Русский" data-language-local-name="ruština" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-scn mw-list-item"><a href="https://scn.wikipedia.org/wiki/Istidina" title="Istidina – sicilština" lang="scn" hreflang="scn" data-title="Istidina" data-language-autonym="Sicilianu" data-language-local-name="sicilština" class="interlanguage-link-target"><span>Sicilianu</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Histidin" title="Histidin – srbochorvatština" lang="sh" hreflang="sh" data-title="Histidin" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="srbochorvatština" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Histidine" title="Histidine – Simple English" lang="en-simple" hreflang="en-simple" data-title="Histidine" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Histid%C3%ADn" title="Histidín – slovenština" lang="sk" hreflang="sk" data-title="Histidín" data-language-autonym="Slovenčina" data-language-local-name="slovenština" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Histidin" title="Histidin – slovinština" lang="sl" hreflang="sl" data-title="Histidin" data-language-autonym="Slovenščina" data-language-local-name="slovinština" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%A5%D0%B8%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Хистидин – srbština" lang="sr" hreflang="sr" data-title="Хистидин" data-language-autonym="Српски / srpski" data-language-local-name="srbština" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-su mw-list-item"><a href="https://su.wikipedia.org/wiki/Histidin" title="Histidin – sundština" lang="su" hreflang="su" data-title="Histidin" data-language-autonym="Sunda" data-language-local-name="sundština" class="interlanguage-link-target"><span>Sunda</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Histidin" title="Histidin – švédština" lang="sv" hreflang="sv" data-title="Histidin" data-language-autonym="Svenska" data-language-local-name="švédština" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%B9%E0%AE%BF%E0%AE%B8%E0%AF%8D%E0%AE%9F%E0%AE%BF%E0%AE%9F%E0%AE%BF%E0%AE%A9%E0%AF%8D" title="ஹிஸ்டிடின் – tamilština" lang="ta" hreflang="ta" data-title="ஹிஸ்டிடின்" data-language-autonym="தமிழ்" data-language-local-name="tamilština" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Histidin" title="Histidin – turečtina" lang="tr" hreflang="tr" data-title="Histidin" data-language-autonym="Türkçe" data-language-local-name="turečtina" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%93%D1%96%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Гістидин – ukrajinština" lang="uk" hreflang="uk" data-title="Гістидин" data-language-autonym="Українська" data-language-local-name="ukrajinština" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Gistidin" title="Gistidin – uzbečtina" lang="uz" hreflang="uz" data-title="Gistidin" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="uzbečtina" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Histidin" title="Histidin – vietnamština" lang="vi" hreflang="vi" data-title="Histidin" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamština" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-wuu mw-list-item"><a href="https://wuu.wikipedia.org/wiki/%E7%BB%84%E6%B0%A8%E9%85%B8" title="组氨酸 – čínština (dialekty Wu)" lang="wuu" hreflang="wuu" data-title="组氨酸" data-language-autonym="吴语" data-language-local-name="čínština (dialekty Wu)" class="interlanguage-link-target"><span>吴语</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E7%B5%84%E6%B0%A8%E9%85%B8" title="組氨酸 – čínština" lang="zh" hreflang="zh" data-title="組氨酸" data-language-autonym="中文" data-language-local-name="čínština" class="interlanguage-link-target"><span>中文</span></a></li><li class="interlanguage-link interwiki-zh-min-nan mw-list-item"><a href="https://zh-min-nan.wikipedia.org/wiki/Histidin" title="Histidin – čínština (dialekty Minnan)" lang="nan" hreflang="nan" data-title="Histidin" data-language-autonym="閩南語 / Bân-lâm-gú" data-language-local-name="čínština (dialekty Minnan)" class="interlanguage-link-target"><span>閩南語 / Bân-lâm-gú</span></a></li><li class="interlanguage-link interwiki-zh-yue mw-list-item"><a href="https://zh-yue.wikipedia.org/wiki/%E7%B5%84%E6%B0%A8%E9%85%B8" title="組氨酸 – kantonština" lang="yue" hreflang="yue" data-title="組氨酸" data-language-autonym="粵語" data-language-local-name="kantonština" class="interlanguage-link-target"><span>粵語</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q485277#sitelinks-wikipedia" title="Editovat mezijazykové odkazy" class="wbc-editpage">Upravit odkazy</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Jmenné prostory"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Histidin" title="Zobrazit obsahovou stránku [c]" accesskey="c"><span>Článek</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Diskuse:Histidin" rel="discussion" title="Diskuse ke stránce [t]" accesskey="t"><span>Diskuse</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Změnit variantu jazyka" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">čeština</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Zobrazení"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Histidin"><span>Číst</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Histidin&veaction=edit" title="Editovat tuto stránku [v]" accesskey="v"><span>Editovat</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Histidin&action=edit" title="Editovat zdrojový kód této stránky [e]" accesskey="e"><span>Editovat zdroj</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Histidin&action=history" title="Starší verze této stránky. [h]" accesskey="h"><span>Zobrazit historii</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Nástroje ke stránce"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Nástroje" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Nástroje</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Nástroje</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">přesunout do postranního panelu</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">skrýt</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Další možnosti" > <div class="vector-menu-heading"> Akce </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Histidin"><span>Číst</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Histidin&veaction=edit" title="Editovat tuto stránku [v]" accesskey="v"><span>Editovat</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Histidin&action=edit" title="Editovat zdrojový kód této stránky [e]" accesskey="e"><span>Editovat zdroj</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Histidin&action=history"><span>Zobrazit historii</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Obecné </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:Co_odkazuje_na/Histidin" title="Seznam všech wikistránek, které sem odkazují [j]" accesskey="j"><span>Odkazuje sem</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:Souvisej%C3%ADc%C3%AD_zm%C4%9Bny/Histidin" rel="nofollow" title="Nedávné změny stránek, na které je odkazováno [k]" accesskey="k"><span>Související změny</span></a></li><li id="t-upload" class="mw-list-item"><a href="//commons.wikimedia.org/wiki/Special:UploadWizard?uselang=cs" title="Nahrát obrázky či jiná multimédia [u]" accesskey="u"><span>Načíst soubor</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:Speci%C3%A1ln%C3%AD_str%C3%A1nky" title="Seznam všech speciálních stránek [q]" accesskey="q"><span>Speciální stránky</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Histidin&oldid=24023440" title="Trvalý odkaz na současnou verzi této stránky"><span>Trvalý odkaz</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Histidin&action=info" title="Více informací o této stránce"><span>Informace o stránce</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:Citovat&page=Histidin&id=24023440&wpFormIdentifier=titleform" title="Informace o tom, jak citovat tuto stránku"><span>Citovat stránku</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:UrlShortener&url=https%3A%2F%2Fcs.wikipedia.org%2Fwiki%2FHistidin"><span>Získat zkrácené URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:QrCode&url=https%3A%2F%2Fcs.wikipedia.org%2Fwiki%2FHistidin"><span>Stáhnout QR kód</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Tisk/export </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:Kniha&bookcmd=book_creator&referer=Histidin"><span>Vytvořit knihu</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:DownloadAsPdf&page=Histidin&action=show-download-screen"><span>Stáhnout jako PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Histidin&printable=yes" title="Tato stránka v podobě vhodné k tisku [p]" accesskey="p"><span>Verze k tisku</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> Na jiných projektech </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:L-Histidine" hreflang="en"><span>Wikimedia Commons</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q485277" title="Odkaz na propojenou položku datového úložiště [g]" accesskey="g"><span>Položka Wikidat</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Nástroje ke stránce"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Vzhled"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header 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id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="cs" dir="ltr"><table class="infobox" style="width:22em;width:300px;"><tbody><tr><th colspan="2" style="text-align:center;font-size:125%;font-weight:bold;background-color: #ddddff;">Histidin</th></tr><tr><td colspan="2" style="text-align:center"><span typeof="mw:File"><a href="/wiki/Soubor:Histidin_-_Histidine.svg" class="mw-file-description" title="strukturní vzorec"><img alt="strukturní vzorec" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/Histidin_-_Histidine.svg/200px-Histidin_-_Histidine.svg.png" decoding="async" width="200" height="109" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/Histidin_-_Histidine.svg/300px-Histidin_-_Histidine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/18/Histidin_-_Histidine.svg/400px-Histidin_-_Histidine.svg.png 2x" data-file-width="512" data-file-height="279" /></a></span><div>strukturní vzorec</div></td></tr><tr><td colspan="2" style="text-align:center"><span typeof="mw:File"><a href="/wiki/Soubor:L-histidine-3D-sticks2.png" class="mw-file-description"><img alt="model molekuly" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d9/L-histidine-3D-sticks2.png/180px-L-histidine-3D-sticks2.png" decoding="async" width="180" height="186" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d9/L-histidine-3D-sticks2.png/270px-L-histidine-3D-sticks2.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d9/L-histidine-3D-sticks2.png/360px-L-histidine-3D-sticks2.png 2x" data-file-width="721" data-file-height="744" /></a></span><div>model molekuly</div></td></tr><tr><th colspan="2" style="text-align:center;background-color: #ddddff;">Obecné</th></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/Systematick%C3%BD_n%C3%A1zev" title="Systematický název">Systematický název</a></th><td><span style="display:inline-block; word-break:break-all; max-width:300px">2-amino-3-(1<i>H</i>-imidazol-4-yl)propanová kyselina</span></td></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/Trivi%C3%A1ln%C3%AD_n%C3%A1zev" title="Triviální název">Triviální název</a></th><td>Histidin</td></tr><tr><th scope="row" style="text-align:left">Ostatní názvy</th><td>glyoxalin-5-alanin</td></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/Anglick%C3%A9_chemick%C3%A9_n%C3%A1zvoslov%C3%AD" title="Anglické chemické názvosloví">Anglický název</a></th><td>Histidine</td></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/Chemick%C3%BD_vzorec#Sumární_vzorec" title="Chemický vzorec">Sumární vzorec</a></th><td>C<sub>6</sub>H<sub>9</sub>N<sub>3</sub>O<sub>2</sub></td></tr><tr><th scope="row" style="text-align:left">Vzhled</th><td>bílé <a href="/wiki/Krystal" title="Krystal">krystaly</a></td></tr><tr><th colspan="2" style="text-align:center;background-color: #ddddff;">Identifikace</th></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/Registra%C4%8Dn%C3%AD_%C4%8D%C3%ADslo_CAS" title="Registrační číslo CAS">Registrační číslo CAS</a></th><td><a rel="nofollow" class="external text" href="http://webbook.nist.gov/cgi/cbook.cgi?Name=71-00-1&Units=SI">71-00-1</a></td></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/PubChem" title="PubChem">PubChem</a></th><td><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=773">773</a></td></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/SMILES" title="SMILES">SMILES</a></th><td><span style="display:inline-block; word-break:break-all; max-width:300px">c1c(nc[nH]1)C[C@@H](C(=O)O)N</span></td></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/InChI" title="InChI">InChI</a></th><td><span style="display:inline-block; word-break:break-all; max-width:300px">InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1</span></td></tr><tr><th colspan="2" style="text-align:center;background-color: #ddddff;">Vlastnosti</th></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/Mol%C3%A1rn%C3%AD_hmotnost" title="Molární hmotnost">Molární hmotnost</a></th><td>155,16 g/mol</td></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/Teplota_t%C3%A1n%C3%AD" title="Teplota tání">Teplota tání</a></th><td>282–287 °C</td></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/Disocia%C4%8Dn%C3%AD_konstanta" title="Disociační konstanta">Disociační konstanta</a> p<i>K</i><sub>a</sub></th><td>1,78</td></tr><tr><th scope="row" style="text-align:left"><a href="/wiki/Disocia%C4%8Dn%C3%AD_konstanta" title="Disociační konstanta">Disociační konstanta</a> p<i>K</i><sub>b</sub></th><td>5,97</td></tr><tr><th colspan="2" style="text-align:center;background-color: #ddddff;">Bezpečnost</th></tr><tr><td colspan="2" style="text-align:center"><div style="display:inline-block; text-align:center"><span typeof="mw:File"><a href="/wiki/Glob%C3%A1ln%C4%9B_harmonizovan%C3%BD_syst%C3%A9m_klasifikace_a_ozna%C4%8Dov%C3%A1n%C3%AD_chemik%C3%A1li%C3%AD" title="GHS07 – dráždivé látky"><img alt="GHS07 – dráždivé látky" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/GHS-pictogram-exclam.svg/75px-GHS-pictogram-exclam.svg.png" decoding="async" width="75" height="75" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/GHS-pictogram-exclam.svg/113px-GHS-pictogram-exclam.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c3/GHS-pictogram-exclam.svg/150px-GHS-pictogram-exclam.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span><br /><small><i>GHS07</i></small></div><sup id="cite_ref-pubchem_cid_6274_1-0" class="reference"><a href="#cite_note-pubchem_cid_6274-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><br /><span style="font-weight:medium; border-bottom:2px solid steelblue">Varování</span><sup id="cite_ref-pubchem_cid_6274_1-1" class="reference"><a href="#cite_note-pubchem_cid_6274-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><td colspan="2" style="text-align:center;background-color: #ddddff;"><div style="font-weight: bold">Není-li uvedeno jinak, jsou použity<br />jednotky <a href="/wiki/Soustava_SI" title="Soustava SI">SI</a> a <a href="/wiki/Standardn%C3%AD_teplota_a_tlak" title="Standardní teplota a tlak">STP</a> (25 °C, 100 kPa).</div><hr /><div style="font-size: smaller">Některá data mohou pocházet z <a href="https://www.wikidata.org/wiki/Q485277" class="extiw" title="d:Q485277">datové položky</a>.</div></td></tr></tbody></table> <p><b>Histidin</b> (zkratky <b>His</b> nebo <b>H</b>) je jedna z nejběžnějších přírodních <a href="/wiki/Aminokyselina" title="Aminokyselina">aminokyselin</a> přítomných v <a href="/wiki/B%C3%ADlkovina" title="Bílkovina">proteinech</a>. Ve smyslu <a href="/wiki/V%C3%BD%C5%BEiva" title="Výživa">výživy</a> je u člověka histidin považován za <a href="/wiki/Esenci%C3%A1ln%C3%AD_aminokyseliny" title="Esenciální aminokyseliny">esenciální aminokyselinu</a>. Původně se myslelo, že je esenciální jen u dětí (semiesenciální), ale dlouhodobé studie ukazují, že je nezbytný i pro dospělé.<sup id="cite_ref-pmid1123426_2-0" class="reference"><a href="#cite_note-pmid1123426-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Jeho <a href="/wiki/Genetick%C3%BD_k%C3%B3d" title="Genetický kód">kodóny</a> jsou CAU a CAC. </p><p>Histidin byl poprvé izolován <a href="/wiki/N%C4%9Bmecko" title="Německo">německým</a> lékařem <a href="/wiki/Albrecht_Kossel" title="Albrecht Kossel">Albrechtem Kosselem</a> v roce <a href="/wiki/1896" title="1896">1896</a>.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Funkce_a_vlastnosti">Funkce a vlastnosti</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidin&veaction=edit&section=1" title="Editace sekce: Funkce a vlastnosti" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidin&action=edit&section=1" title="Editovat zdrojový kód sekce Funkce a vlastnosti"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Chemické_vlastnosti"><span id="Chemick.C3.A9_vlastnosti"></span>Chemické vlastnosti</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidin&veaction=edit&section=2" title="Editace sekce: Chemické vlastnosti" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidin&action=edit&section=2" title="Editovat zdrojový kód sekce Chemické vlastnosti"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Histidin se řadí mezi bazické aminokyseliny, vzhledem k <a href="/wiki/Disocia%C4%8Dn%C3%AD_konstanta" title="Disociační konstanta">disociační konstantě</a> (pK<sub>a</sub>) své <a href="/wiki/Imidazol" title="Imidazol">imidazolové</a> postranní skupiny ležící v neutrálním pH je ale jeho náboj ve fyziologických podmínkách velmi citlivý na změny <a href="/wiki/PH" title="PH">pH</a>: teoreticky je pK<sub>a</sub> histidinu 6, v nižším (kyselejším) pH je tedy histidin protonovaný a nese kladný náboj, při vyšším pH není nabitý. Jeho skutečná pK<sub>a</sub> se v proteinech ovšem může pohybovat mezi pH 4–10 v závislosti na okolním prostředí.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Díky této vlastnosti umožňuje proteinům citlivě reagovat na změny pH, například <a href="/wiki/Hemoglobin#Bohrův_efekt" title="Hemoglobin">Bohrův efekt</a> (schopnost <a href="/wiki/Hemoglobin" title="Hemoglobin">hemoglobinu</a> uvolnit <a href="/wiki/Kysl%C3%ADk" title="Kyslík">kyslík</a> v kyselejším – odkysličeném – prostředí) je závislý právě na této vlastnosti histidinu.<sup id="cite_ref-pmid24224786_5-0" class="reference"><a href="#cite_note-pmid24224786-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>Imidazolová postranní skupina má <a href="/wiki/Aromaticita" title="Aromaticita">aromatický charakter</a>,<sup id="cite_ref-pmid17105194_6-0" class="reference"><a href="#cite_note-pmid17105194-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> kladný náboj získávaný v kyselém pH ale možné <a href="/wiki/Patrov%C3%A9_interakce" title="Patrové interakce">patrové interakce</a> komplikuje. </p> <div class="mw-heading mw-heading3"><h3 id="Význam_v_proteinech"><span id="V.C3.BDznam_v_proteinech"></span>Význam v proteinech</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidin&veaction=edit&section=3" title="Editace sekce: Význam v proteinech" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidin&action=edit&section=3" title="Editovat zdrojový kód sekce Význam v proteinech"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>V proteinech se histidin často vyskytuje v <a href="/wiki/Aktivn%C3%AD_m%C3%ADsto" title="Aktivní místo">aktivních centrech enzymů</a>, místech kontaktů mezi proteiny a slouží k vazbě kovů (<a href="/wiki/Zinek" title="Zinek">zinek</a>, <a href="/wiki/%C5%BDelezo" title="Železo">železo</a>). Vzhledem k jednoduchosti, se kterou může být histidin protonovaný a deprotonovaný, slouží často jako prostředník v přenosu náboje, například v <a href="/w/index.php?title=Katalytick%C3%A1_tri%C3%A1da&action=edit&redlink=1" class="new" title="Katalytická triáda (stránka neexistuje)">katalytických triádách</a> tvořících centra <a href="/wiki/Hydrol%C3%A1za" title="Hydroláza">hydroláz</a> a <a href="/wiki/Transfer%C3%A1za" title="Transferáza">transferáz</a>, nejčastěji <a href="/wiki/Prote%C3%A1za#Skupiny_endoproteáz" title="Proteáza">cysteinových</a> a serinových proteáz.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Dalším příkladem může být role v enzymu <a href="/w/index.php?title=Karbonick%C3%A1_anhydr%C3%A1za&action=edit&redlink=1" class="new" title="Karbonická anhydráza (stránka neexistuje)">karbonické anhydráze</a>, ve které jsou v <a href="/wiki/Aktivn%C3%AD_m%C3%ADsto" title="Aktivní místo">aktivním místě</a> čtyři histidiny – tři drží atom <a href="/wiki/Zinek" title="Zinek">zinku</a>, který z vody odtrhne skupinu -OH, a čtvrtý naváže zbylý <a href="/wiki/Vod%C3%ADk" title="Vodík">vodík</a>. Na -OH skupinu se následně naváže <a href="/wiki/Oxid_uhli%C4%8Dit%C3%BD" title="Oxid uhličitý">oxid uhličitý</a> a vzniká rozpustný <a href="/wiki/Hydrogenuhli%C4%8Ditany" title="Hydrogenuhličitany">hydrogenuhličitan</a>, v jehož podobě je oxid uhličitý přepravován krví. </p> <div class="mw-heading mw-heading3"><h3 id="Další_využití"><span id="Dal.C5.A1.C3.AD_vyu.C5.BEit.C3.AD"></span>Další využití</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidin&veaction=edit&section=4" title="Editace sekce: Další využití" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidin&action=edit&section=4" title="Editovat zdrojový kód sekce Další využití"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>V lidském těle funguje histidin jako <a href="/wiki/Prekurzor_(chemie)" title="Prekurzor (chemie)">prekurzor</a> pro výrobu <a href="/wiki/Histamin" title="Histamin">histaminu</a> a <a href="/wiki/Karnosin" title="Karnosin">karnosinu</a>. Histamin je signální <a href="/wiki/Molekula" title="Molekula">molekula</a> spouštějící zánětlivou reakci a slouží jako <a href="/wiki/Neurotransmiter" title="Neurotransmiter">neurotransmiter</a>, z histidinu vzniká <a href="/wiki/Dekarboxylace" title="Dekarboxylace">dekarboxylací</a>. Při vazbě <a href="/w/index.php?title=Beta-alanin&action=edit&redlink=1" class="new" title="Beta-alanin (stránka neexistuje)">beta-alaninu</a> na histidin se vytváří <a href="/wiki/Karnosin" title="Karnosin">karnosin</a>, jehož <a href="/wiki/Disocia%C4%8Dn%C3%AD_konstanta" title="Disociační konstanta">disociační konstanta</a> je posunutá ještě blíže k fyziologickému pH (pK<sub>a</sub> = 6,83), čímž slouží jako výborný <a href="/wiki/Pufr" title="Pufr">pufr</a>, který je využíván především ve <a href="/wiki/Sval" title="Sval">svalech</a>. </p><p>V <a href="/wiki/Molekul%C3%A1rn%C3%AD_biologie" title="Molekulární biologie">molekulární biologii</a> se využívá tzv. <a href="/w/index.php?title=Polyhistidinov%C3%BD_tag&action=edit&redlink=1" class="new" title="Polyhistidinový tag (stránka neexistuje)">polyhistidinový tag</a>, což je sekvence šesti histidinů připojených ke studovanému proteinu metodami <a href="/wiki/Genov%C3%A9_in%C5%BEen%C3%BDrstv%C3%AD" class="mw-redirect" title="Genové inženýrství">genového inženýrství</a>, která slouží pro detekci a <a href="/wiki/Afinitn%C3%AD_chromatografie" title="Afinitní chromatografie">afinitní purifikaci</a> zkoumaného proteinu. </p> <div class="mw-heading mw-heading2"><h2 id="Posttranslační_modifikace"><span id="Posttransla.C4.8Dn.C3.AD_modifikace"></span>Posttranslační modifikace</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidin&veaction=edit&section=5" title="Editace sekce: Posttranslační modifikace" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidin&action=edit&section=5" title="Editovat zdrojový kód sekce Posttranslační modifikace"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/Soubor:Diphthamide.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Diphthamide.png/200px-Diphthamide.png" decoding="async" width="200" height="87" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Diphthamide.png/300px-Diphthamide.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Diphthamide.png/400px-Diphthamide.png 2x" data-file-width="714" data-file-height="310" /></a><figcaption>Dipthamid, jedna z modifikací histidinu</figcaption></figure> <p>Histidin je jednou z aminokyselin, které mohou být <a href="/wiki/Posttransla%C4%8Dn%C3%AD_modifikace" title="Posttranslační modifikace">posttranslačně modifikovány</a> <a href="/wiki/Fosforylace" title="Fosforylace">fosforylací</a>. Toho využívá bakteriální <a href="/w/index.php?title=Dvoukomponentov%C3%BD_regula%C4%8Dn%C3%AD_syst%C3%A9m&action=edit&redlink=1" class="new" title="Dvoukomponentový regulační systém (stránka neexistuje)">dvoukomponentový regulační systém</a> složený z <a href="/w/index.php?title=Histidinov%C3%A1_kin%C3%A1za&action=edit&redlink=1" class="new" title="Histidinová kináza (stránka neexistuje)">histidinové kinázy</a>, která je nejčastěji vázaná na membránu a po přijetí stimulu fosforyluje sebe sama na histidinech. Vzniká N-fosfo-L-histidin, který není příliš stabilní a fosfát je z něj přesunut na druhou komponentu systému, která je tímto aktivována. Dvoukomponentový regulační systém se vyskytuje u <a href="/wiki/Eukaryota" title="Eukaryota">eukaryot</a> jen vzácně a enzymy příbuzné <a href="/w/index.php?title=Histidinov%C3%A1_kin%C3%A1za&action=edit&redlink=1" class="new" title="Histidinová kináza (stránka neexistuje)">histidinovým kinázám</a> v lidských <a href="/w/index.php?title=Mitochondri%C3%ADch&action=edit&redlink=1" class="new" title="Mitochondriích (stránka neexistuje)">mitochondriích</a> nemají aktivitu histidinových <a href="/wiki/Kin%C3%A1za" title="Kináza">kináz</a>. Navzdory tomu jsou některé proteiny u lidí na histidinech fosforylovány, i když mechanismus ani význam těchto modifikací není dobře prozkoumaný.<sup id="cite_ref-pmid23863173_8-0" class="reference"><a href="#cite_note-pmid23863173-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>V <a href="/w/index.php?title=Eukaryotick%C3%BD_elonga%C4%8Dn%C3%AD_faktor_2&action=edit&redlink=1" class="new" title="Eukaryotický elongační faktor 2 (stránka neexistuje)">eukaryotickém elongačním faktoru 2</a> je histidin modifikován do podoby <a href="/w/index.php?title=Diftamid&action=edit&redlink=1" class="new" title="Diftamid (stránka neexistuje)">diftamidu</a>. Tato modifikace je složitá, vyžaduje čtyři enzymatické kroky a je známá pouze z tohoto proteinu. Její funkce je nejasná, ale je nezbytná pro <a href="/wiki/Proteosynt%C3%A9za" title="Proteosyntéza">proteosyntézu</a> a modifikace dipthamidu (například <a href="/w/index.php?title=Diphtheria_toxin&action=edit&redlink=1" class="new" title="Diphtheria toxin (stránka neexistuje)">diphtheria toxinem</a> při <a href="/wiki/Z%C3%A1%C5%A1krt" title="Záškrt">záškrtu</a>) vede ke smrti buněk.<sup id="cite_ref-pmid25352115_9-0" class="reference"><a href="#cite_note-pmid25352115-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Zdroje">Zdroje</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidin&veaction=edit&section=6" title="Editace sekce: Zdroje" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidin&action=edit&section=6" title="Editovat zdrojový kód sekce Zdroje"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <table class="noprint metadata plainlinks sectstub" cellpadding="2" style="background: transparent;"> <tbody><tr> <td><span typeof="mw:File"><a href="/wiki/Soubor:Wiki_letter_w.svg" class="mw-file-description" title="Pahýl"><img alt="Pahýl" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6c/Wiki_letter_w.svg/25px-Wiki_letter_w.svg.png" decoding="async" width="25" height="25" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/6c/Wiki_letter_w.svg/38px-Wiki_letter_w.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/6c/Wiki_letter_w.svg/50px-Wiki_letter_w.svg.png 2x" data-file-width="44" data-file-height="44" /></a></span> </td> <td><i>Tato část článku je příliš stručná nebo <a href="/wiki/Wikipedie:Pah%C3%BDl" title="Wikipedie:Pahýl">postrádá důležité informace</a>. Pomozte Wikipedii tím, že ji vhodně <a class="external text" href="https://cs.wikipedia.org/w/index.php?title=Histidin&action=edit">rozšíříte</a>.</i> </td></tr></tbody></table> <p>Histidin je <a href="/wiki/Esenci%C3%A1ln%C3%AD_aminokyselina" class="mw-redirect" title="Esenciální aminokyselina">esenciální aminokyselina</a>, člověk ji tedy musí přijímat v potravě. </p> <div class="mw-heading mw-heading2"><h2 id="Metabolismus">Metabolismus</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidin&veaction=edit&section=7" title="Editace sekce: Metabolismus" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidin&action=edit&section=7" title="Editovat zdrojový kód sekce Metabolismus"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Degradace">Degradace</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidin&veaction=edit&section=8" title="Editace sekce: Degradace" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidin&action=edit&section=8" title="Editovat zdrojový kód sekce Degradace"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Histidin je u lidí degradován v pěti krocích, po kterých vznikne <a href="/wiki/2-oxoglutar%C3%A1t" title="2-oxoglutarát">alfa-ketoglutarát</a>, který vstupuje do <a href="/wiki/Citr%C3%A1tov%C3%BD_cyklus" title="Citrátový cyklus">cyklu kyseliny citrónové</a>. V prvním kroku enzym <a href="/w/index.php?title=Histidinly%C3%A1za&action=edit&redlink=1" class="new" title="Histidinlyáza (stránka neexistuje)">histidinlyáza</a> přeměňuje histidin na <a href="/wiki/Amoniak" title="Amoniak">amoniak</a> a <a href="/w/index.php?title=Kyselina_urokanov%C3%A1&action=edit&redlink=1" class="new" title="Kyselina urokanová (stránka neexistuje)">kyselinu urokanovou</a>. Nedostatek tohoto enzymu se projevuje ve vzácné <a href="/wiki/Metabolismus" title="Metabolismus">metabolické</a> poruše <a href="/wiki/Histidinemie" title="Histidinemie">histidinemii</a>. Histidin má oproti alfa-ketoglutarátu jeden uhlík navíc, k odpojení uhlíku ve čtvrtém kroku je využíván kofaktor <a href="/wiki/Kyselina_tetrahydrofolov%C3%A1" title="Kyselina tetrahydrofolová">tetrahydrofolát</a>.<sup id="cite_ref-Lehninger_10-0" class="reference"><a href="#cite_note-Lehninger-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Odkazy">Odkazy</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidin&veaction=edit&section=9" title="Editace sekce: Odkazy" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidin&action=edit&section=9" title="Editovat zdrojový kód sekce Odkazy"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Reference">Reference</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidin&veaction=edit&section=10" title="Editace sekce: Reference" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidin&action=edit&section=10" title="Editovat zdrojový kód sekce Reference"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-pubchem_cid_6274-1"><span class="mw-cite-backlink">↑ <a href="#cite_ref-pubchem_cid_6274_1-0"><sup style="font-style: italic; font-weight: bold; vertical-align: top">a</sup></a> <a href="#cite_ref-pubchem_cid_6274_1-1"><sup style="font-style: italic; font-weight: bold; vertical-align: top">b</sup></a></span> <span class="reference-text"><cite style="font-style:normal;"> Histidine. <i>pubchem.ncbi.nlm.nih.gov</i> [online]. PubChem [cit. 2021-05-23]. <a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/6274">Dostupné online</a>. (anglicky)</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceelperiodika&rft.jtitle=pubchem.ncbi.nlm.nih.gov&rft_id=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fcompound%2F6274&rft.atitle=Histidine&rft.pub=PubChem"><span style="display:none"> </span></span></span> </li> <li id="cite_note-pmid1123426-2"><span class="mw-cite-backlink"><a href="#cite_ref-pmid1123426_2-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">KOPPLE, JD.; SWENDSEID, ME. Evidence that histidine is an essential amino acid in normal and chronically uremic man.. <i>J Clin Invest</i>. May 1975, roč. 55, čís. 5, s. 881–91. <a rel="nofollow" class="external text" href="https://archive.org/details/sim_journal-of-clinical-investigation_1975-05_55_5/page/881">Dostupné online</a>. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a> <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1172%2FJCI108016">10.1172/JCI108016</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/1123426"><span class="PMID">1123426</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=J+Clin+Invest&rft_id=info:doi/10.1172%2FJCI108016&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_journal-of-clinical-investigation_1975-05_55_5%2Fpage%2F881&rft.atitle=Evidence+that+histidine+is+an+essential+amino+acid+in+normal+and+chronically+uremic+man.&rft.date=1975&rft.chron=May&rft.volume=55&rft.issue=5&rft.pages=881%E2%80%9391&rft.aulast=Kopple&rft.aufirst=JD.&rft.au=Swendseid%2C+ME."><span style="display:none"> </span></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">JONES, M. E. Albrecht Kossel, a biographical sketch. <i>Yale J Biol Med.</i>. 1953, roč. 26, čís. 1, s. 80–97. <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2599350/?tool=pubmed">Dostupné online</a>. <a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <a rel="nofollow" class="external text" href="https://worldcat.org/issn/0044-0086">0044-0086</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Yale+J+Biol+Med.&rft_id=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2599350%2F%3Ftool%3Dpubmed&rft.atitle=Albrecht+Kossel%2C+a+biographical+sketch&rft.date=1953&rft.volume=26&rft.issue=1&rft.pages=80%E2%80%9397&rft.issn=0044-0086&rft.aulast=JONES&rft.aufirst=M.+E."><span style="display:none"> </span></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text"><cite class="book" style="font-style:normal;">WHITFORD, David. <i>Proteins: Structure and Function</i>. 1.. vyd. [s.l.]: Wiley, 2005. 542 s. <a rel="nofollow" class="external text" href="https://archive.org/details/proteinsstructur0000whit">Dostupné online</a>. <span style="white-space:nowrap"><a href="/wiki/International_Standard_Book_Number" title="International Standard Book Number">ISBN</a> <a href="/wiki/Speci%C3%A1ln%C3%AD:Zdroje_knih/978-0471498940" title="Speciální:Zdroje knih/978-0471498940"><span class="ISBN">978-0471498940</span></a></span>. Kapitola 2. Amino acids: the building blocks of proteins, s. 44–45. (anglicky)</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rfr_id=info:sid/cs.wikipedia.org:templatecitacemonografie&rft.btitle=Proteins%3A+Structure+and+Function&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fproteinsstructur0000whit&rft.isbn=978-0471498940&rft.aulast=Whitford&rft.aufirst=David&rft.atitle=2.+Amino+acids%3A+the+building+blocks+of+proteins&rft.pub=Wiley&rft.date=2005&rft.edition=1.&rft.tpages=542&rft.pages=44%E2%80%9345"><span style="display:none"> </span></span></span> </li> <li id="cite_note-pmid24224786-5"><span class="mw-cite-backlink"><a href="#cite_ref-pmid24224786_5-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">ZHENG, G.; SCHAEFER, M.; KARPLUS, M. Hemoglobin Bohr effects: atomic origin of the histidine residue contributions.. <i>Biochemistry</i>. Nov 2013, roč. 52, čís. 47, s. 8539–55. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a> <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1021%2Fbi401126z">10.1021/bi401126z</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/24224786"><span class="PMID">24224786</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Biochemistry&rft_id=info:doi/10.1021%2Fbi401126z&rft.atitle=Hemoglobin+Bohr+effects%3A+atomic+origin+of+the+histidine+residue+contributions.&rft.date=2013&rft.chron=Nov&rft.volume=52&rft.issue=47&rft.pages=8539%E2%80%9355&rft.aulast=Zheng&rft.aufirst=G.&rft.au=Schaefer%2C+M.&rft.au=Karplus%2C+M."><span style="display:none"> </span></span></span> </li> <li id="cite_note-pmid17105194-6"><span class="mw-cite-backlink"><a href="#cite_ref-pmid17105194_6-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">WANG, L.; SUN, N.; TERZYAN, S., et al. A histidine/tryptophan pi-stacking interaction stabilizes the heme-independent folding core of microsomal apocytochrome b5 relative to that of mitochondrial apocytochrome b5.. <i>Biochemistry</i>. Nov 2006, roč. 45, čís. 46, s. 13 750 – 13 759. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a> <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1021%2Fbi0615689">10.1021/bi0615689</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/17105194"><span class="PMID">17105194</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Biochemistry&rft_id=info:doi/10.1021%2Fbi0615689&rft.atitle=A+histidine%2Ftryptophan+pi-stacking+interaction+stabilizes+the+heme-independent+folding+core+of+microsomal+apocytochrome+b5+relative+to+that+of+mitochondrial+apocytochrome+b5.&rft.date=2006&rft.chron=Nov&rft.volume=45&rft.issue=46&rft.pages=13+750+%E2%80%93+13+759&rft.aulast=Wang&rft.aufirst=L.&rft.au=Sun%2C+N.&rft.au=Terzyan%2C+S."><span style="display:none"> </span></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text"><cite class="book" style="font-style:normal;">BARNES, Michael R. <i>Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data</i>. [s.l.]: Wiley, 2007. 576 s. <span style="white-space:nowrap"><a href="/wiki/International_Standard_Book_Number" title="International Standard Book Number">ISBN</a> <a href="/wiki/Speci%C3%A1ln%C3%AD:Zdroje_knih/978-0470026205" title="Speciální:Zdroje knih/978-0470026205"><span class="ISBN">978-0470026205</span></a></span>. Kapitola 14: Amino Acid Properties and Consequences of Substitutions, s. en. (anglicky)</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rfr_id=info:sid/cs.wikipedia.org:templatecitacemonografie&rft.btitle=Bioinformatics+for+Geneticists%3A+A+Bioinformatics+Primer+for+the+Analysis+of+Genetic+Data&rft.isbn=978-0470026205&rft.aulast=Barnes&rft.aufirst=Michael+R.&rft.atitle=14%3A+Amino+Acid+Properties+and+Consequences+of+Substitutions&rft.pub=Wiley&rft.date=2007&rft.tpages=576&rft.pages=en"><span style="display:none"> </span></span></span> </li> <li id="cite_note-pmid23863173-8"><span class="mw-cite-backlink"><a href="#cite_ref-pmid23863173_8-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">ATTWOOD, PV. Histidine kinases from bacteria to humans.. <i>Biochem Soc Trans</i>. Aug 2013, roč. 41, čís. 4, s. 1023–8. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a> <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1042%2FBST20130019">10.1042/BST20130019</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/23863173"><span class="PMID">23863173</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Biochem+Soc+Trans&rft_id=info:doi/10.1042%2FBST20130019&rft.atitle=Histidine+kinases+from+bacteria+to+humans.&rft.date=2013&rft.chron=Aug&rft.volume=41&rft.issue=4&rft.pages=1023%E2%80%938&rft.aulast=Attwood&rft.aufirst=PV."><span style="display:none"> </span></span></span> </li> <li id="cite_note-pmid25352115-9"><span class="mw-cite-backlink"><a href="#cite_ref-pmid25352115_9-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">SCHAFFRATH, R.; ABDEL-FATTAH, W.; KLASSEN, R., et al. The diphthamide modification pathway from Saccharomyces cerevisiae - revisited.. <i>Mol Microbiol</i>. Dec 2014, roč. 94, čís. 6, s. 1213–26. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a> <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1111%2Fmmi.12845">10.1111/mmi.12845</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/25352115"><span class="PMID">25352115</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Mol+Microbiol&rft_id=info:doi/10.1111%2Fmmi.12845&rft.atitle=The+diphthamide+modification+pathway+from+Saccharomyces+cerevisiae+-+revisited.&rft.date=2014&rft.chron=Dec&rft.volume=94&rft.issue=6&rft.pages=1213%E2%80%9326&rft.aulast=Schaffrath&rft.aufirst=R.&rft.au=Abdel-Fattah%2C+W.&rft.au=Klassen%2C+R."><span style="display:none"> </span></span></span> </li> <li id="cite_note-Lehninger-10"><span class="mw-cite-backlink"><a href="#cite_ref-Lehninger_10-0">↑</a></span> <span class="reference-text"><cite class="book" style="font-style:normal;">NELSON, David L.; COX, Michael M. <i>Lehninger Principles of Biochemistry</i>. [s.l.]: W.H. Freeman, 2013. <a rel="nofollow" class="external text" href="https://archive.org/details/lehningerprincip0000lehn">Dostupné online</a>. <span style="white-space:nowrap"><a href="/wiki/International_Standard_Book_Number" title="International Standard Book Number">ISBN</a> <a href="/wiki/Speci%C3%A1ln%C3%AD:Zdroje_knih/978-1429234146" title="Speciální:Zdroje knih/978-1429234146"><span class="ISBN">978-1429234146</span></a></span>. Kapitola 18: Amino Acid Oxidation and the Production of Urea. (anglicky)</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rfr_id=info:sid/cs.wikipedia.org:templatecitacemonografie&rft.btitle=Lehninger+Principles+of+Biochemistry&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Flehningerprincip0000lehn&rft.isbn=978-1429234146&rft.aulast=Nelson&rft.aufirst=David+L.&rft.au=Cox%2C+Michael+M.&rft.atitle=18%3A+Amino+Acid+Oxidation+and+the+Production+of+Urea&rft.pub=W.H.+Freeman&rft.date=2013"><span style="display:none"> </span></span></span> </li> </ol></div> <div class="mw-heading mw-heading3"><h3 id="Externí_odkazy"><span id="Extern.C3.AD_odkazy"></span>Externí odkazy</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidin&veaction=edit&section=11" title="Editace sekce: Externí odkazy" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidin&action=edit&section=11" title="Editovat zdrojový kód sekce Externí odkazy"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><span class="wd"><span class="sisterproject sisterproject-commons"><span class="sisterproject_image"><span typeof="mw:File"><a href="/wiki/Wikimedia_Commons" title="Wikimedia Commons"><img alt="Logo Wikimedia Commons" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/12px-Commons-logo.svg.png" decoding="async" width="12" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/24px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span></span> <span class="sisterproject_text">Obrázky, zvuky či videa k tématu <span class="sisterproject_text_target"><a href="https://commons.wikimedia.org/wiki/Category:L-Histidine" class="extiw" title="c:Category:L-Histidine">Histidin</a></span> na <a href="/wiki/Wikimedia_Commons" title="Wikimedia Commons">Wikimedia Commons</a></span></span></span><i> </i></li> <li><a rel="nofollow" class="external text" href="https://web.archive.org/web/20110726040606/http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/AminoAcid/His1.html">Biosyntéza histidinu (Raná fáze)</a></li> <li><a rel="nofollow" class="external text" href="https://web.archive.org/web/20101129095122/http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/AminoAcid/His2.html">Biosyntéza histidinu (Pozdní fáze)</a></li> <li><a rel="nofollow" class="external text" href="https://web.archive.org/web/20121015163903/http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/AminoAcid/His3.html">Katabolismus histidinu</a></li></ul> <table class="plainlinks metadata noprint pahyl" cellpadding="2" style="background: transparent;"> <tbody><tr> <td><figure class="mw-halign-left" typeof="mw:File"><a href="/wiki/Soubor:Wiki_letter_w.svg" class="mw-file-description" title="Pahýl"><img alt="Pahýl" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6c/Wiki_letter_w.svg/40px-Wiki_letter_w.svg.png" decoding="async" width="40" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/6c/Wiki_letter_w.svg/60px-Wiki_letter_w.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/6c/Wiki_letter_w.svg/80px-Wiki_letter_w.svg.png 2x" data-file-width="44" data-file-height="44" /></a><figcaption>Pahýl</figcaption></figure> </td> <td><i>Tento článek je příliš stručný nebo <a href="/wiki/Wikipedie:Pah%C3%BDl" title="Wikipedie:Pahýl">postrádá důležité informace</a>.<br />Pomozte Wikipedii tím, že jej vhodně <a class="external text" href="https://cs.wikipedia.org/w/index.php?title=Histidin&action=edit">rozšíříte</a>. Nevkládejte však <a href="/wiki/Wikipedie:Autorsk%C3%A9_pr%C3%A1vo#Publikování_cizích_autorských_děl" title="Wikipedie:Autorské právo">bez oprávnění</a> cizí texty.</i> </td></tr></tbody></table> <div class="navbox noprint" title="Aminokyseliny"><table title="" class="navbox-navbox mw-collapsible autocollapse nowraplinks noprint hlist" cellspacing="0" data-collapsetext="skrýt" data-expandtext="zobrazit"><style data-mw-deduplicate="TemplateStyles:r17064757">.mw-parser-output .navbox-title .mw-collapsible-toggle{font-weight:normal}</style><tbody><tr> <th class="navbox-title" colspan="2"> <span class="navbox-titletext"><a href="/wiki/Aminokyselina#Proteinogenní_aminokyseliny" title="Aminokyselina">Proteinogenní aminokyseliny</a></span> </th> </tr><tr class="navbox-padding"><td></td></tr> <tr> <td class="navbox-group">Obecná témata</td> <td class="navbox-list navbox-odd"> <div> <ul><li><a href="/wiki/Aminokyselina" title="Aminokyselina">Aminokyselina</a></li> <li><a href="/wiki/Peptid" title="Peptid">Peptid</a></li> <li><a href="/wiki/B%C3%ADlkovina" title="Bílkovina">Protein</a></li> <li><a href="/wiki/Genetick%C3%BD_k%C3%B3d" title="Genetický kód">Genetický kód</a></li></ul></div> </td> </tr><tr class="navbox-padding"><td></td></tr> <tr> <td class="navbox-group">Rozdělení</td> <td class="navbox-list navbox-even"> <div> </div><table title="" class="navbox-subgroup nowraplinks noprint" cellspacing="0" data-collapsetext="skrýt" data-expandtext="zobrazit"><tbody><tr class="navbox-padding"><td></td></tr> <tr> <td class="navbox-group"><a href="/wiki/Alifatick%C3%A1_slou%C4%8Denina" title="Alifatická sloučenina">Alifatické</a></td> <td class="navbox-list navbox-odd"> <div> <ul><li><a href="/w/index.php?title=Aminokyseliny_s_rozv%C4%9Btven%C3%BDm_%C5%99et%C4%9Bzcem&action=edit&redlink=1" class="new" title="Aminokyseliny s rozvětveným řetězcem (stránka neexistuje)">S rozvětveným řetězcem</a> (<a href="/wiki/Valin" title="Valin">Valin</a></li> <li><a href="/wiki/Isoleucin" title="Isoleucin">Isoleucin</a></li> <li><a href="/wiki/Leucin" title="Leucin">Leucin</a>)</li> <li><a href="/wiki/Methionin" title="Methionin">Methionin</a></li> <li><a href="/wiki/Alanin" title="Alanin">Alanin</a></li> <li><a href="/wiki/Prolin" title="Prolin">Prolin</a></li> <li><a href="/wiki/Glycin" title="Glycin">Glycin</a></li></ul></div> </td> </tr><tr class="navbox-padding"><td></td></tr> <tr> <td class="navbox-group"><a href="/wiki/Aromaticita" title="Aromaticita">Aromatické</a></td> <td class="navbox-list navbox-even"> <div> <li><a href="/wiki/Fenylalanin" title="Fenylalanin">Fenylalanin</a></li> <li><a href="/wiki/Tyrosin" title="Tyrosin">Tyrosin</a></li> <li><a href="/wiki/Tryptofan" title="Tryptofan">Tryptofan</a></li> <li><a class="mw-selflink selflink">Histidin</a></li></div> </td> </tr><tr class="navbox-padding"><td></td></tr> <tr> <td class="navbox-group"><a href="/wiki/Pol%C3%A1rn%C3%AD_molekula" title="Polární molekula">Polární</a>, nenabité</td> <td class="navbox-list navbox-odd"> <div> <li><a href="/wiki/Asparagin" title="Asparagin">Asparagin</a></li> <li><a href="/wiki/Glutamin" title="Glutamin">Glutamin</a></li> <li><a href="/wiki/Serin" title="Serin">Serin</a></li> <li><a href="/wiki/Threonin" title="Threonin">Threonin</a></li></div> </td> </tr><tr class="navbox-padding"><td></td></tr> <tr> <td class="navbox-group">Nesoucí pozitivní náboj (p<i>K</i><sub>a</sub>)</td> <td class="navbox-list navbox-even"> <div> <li><a href="/wiki/Lysin" title="Lysin">Lysin</a> (≈10,8)</li> <li><a href="/wiki/Arginin" title="Arginin">Arginin</a> (≈12,5)</li> <li><a class="mw-selflink selflink">Histidin</a> (≈6,1)</li></div> </td> </tr><tr class="navbox-padding"><td></td></tr> <tr> <td class="navbox-group">Nesoucí negativní náboj (p<i>K</i><sub>a</sub>)</td> <td class="navbox-list navbox-odd"> <div> <li><a href="/wiki/Kyselina_asparagov%C3%A1" title="Kyselina asparagová">Kyselina asparagová</a> (≈3,9)</li> <li><a href="/wiki/Kyselina_glutamov%C3%A1" title="Kyselina glutamová">Kyselina glutamová</a> (≈4,1)</li></div> </td> </tr><tr class="navbox-padding"><td></td></tr> <tr> <td class="navbox-group">Obsahující síru</td> <td class="navbox-list navbox-even"> <div> <li><a href="/wiki/Cystein" title="Cystein">Cystein</a></li> <li><a href="/wiki/Methionin" title="Methionin">Methionin</a></li></div> </td> </tr></tbody></table> <div></div> </td> </tr><tr class="navbox-padding"><td></td></tr> <tr> <td class="navbox-group">Zvláštní případy</td> <td class="navbox-list navbox-odd"> <div> <ul><li><a href="/wiki/Selenocystein" title="Selenocystein">Selenocystein</a></li> <li><a href="/wiki/Pyrolysin" title="Pyrolysin">Pyrolysin</a></li> <li><a href="/wiki/N-formylmethionin" title="N-formylmethionin">N-formylmethionin</a></li></ul></div> </td> </tr><tr class="navbox-padding"><td></td></tr> <tr> <td class="navbox-group">Další rozdělení</td> <td class="navbox-list navbox-even"> <div> <li><a href="/wiki/Esenci%C3%A1ln%C3%AD_aminokyseliny" title="Esenciální aminokyseliny">Esenciální</a></li> <li><a href="/wiki/Ketogenn%C3%AD_aminokyseliny" title="Ketogenní aminokyseliny">Ketogenní</a></li> <li><a href="/wiki/Glukogenn%C3%AD_aminokyseliny" title="Glukogenní aminokyseliny">Glukogenní</a></li></div> </td> </tr></tbody></table> </div> <style data-mw-deduplicate="TemplateStyles:r23078045">.mw-parser-output .navbox2{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox2 .navbox2{margin-top:0}.mw-parser-output .navbox2+.navbox2{margin-top:-1px}.mw-parser-output .navbox2-inner,.mw-parser-output .navbox2-subgroup{width:100%}.mw-parser-output .navbox2-group,.mw-parser-output .navbox2-title,.mw-parser-output .navbox2-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output th.navbox2-group{white-space:nowrap;text-align:right}.mw-parser-output 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href="https://id.ndl.go.jp/auth/ndlna/00563277">00563277</a></span></span></li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r16915398">.mw-parser-output div/**/#portallinks a{font-weight:bold}</style><div id="portallinks" class="catlinks"><a href="/wiki/Port%C3%A1l:Obsah" title="Portál:Obsah">Portály</a>: <a href="/wiki/Port%C3%A1l:Chemie" title="Portál:Chemie">Chemie</a> </div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1&useformat=desktop" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Citováno z „<a dir="ltr" href="https://cs.wikipedia.org/w/index.php?title=Histidin&oldid=24023440">https://cs.wikipedia.org/w/index.php?title=Histidin&oldid=24023440</a>“</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a 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