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id="facet-form-submit" style="display:none">Search</button></div></aside><main id="maincontent"><section class="o-columnbox1"><header><h2 class="o-columnbox1__heading" aria-live="polite">Scholarly Works (3 results)</h2></header><div class="c-sortpagination"><div class="c-sort"><div class="o-input__droplist1"><label for="c-sort1">Sort By:</label><select name="sort" id="c-sort1" form="facetForm"><option selected="" value="rel">Relevance</option><option value="a-title">A-Z By Title</option><option value="z-title">Z-A By Title</option><option value="a-author">A-Z By Author</option><option value="z-author">Z-A By Author</option><option value="asc">Date Ascending</option><option value="desc">Date Descending</option></select></div></div><input type="hidden" name="start" form="facetForm" value="0"/></div><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/9nq1d9g6"><div class="c-clientmarkup">Germline Predisposition and Copy Number Alteration in Pre-stage Lung Adenocarcinomas Presenting as Ground-Glass Nodules</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ARen%2C%20Yijiu">Ren, Yijiu</a>; </li><li><a href="/search/?q=author%3AHuang%2C%20Shujun">Huang, Shujun</a>; </li><li><a href="/search/?q=author%3ADai%2C%20Chenyang">Dai, Chenyang</a>; </li><li><a href="/search/?q=author%3AXie%2C%20Dong">Xie, Dong</a>; </li><li><a href="/search/?q=author%3AZheng%2C%20Larry">Zheng, Larry</a>; </li><li><a href="/search/?q=author%3AXie%2C%20Huikang">Xie, Huikang</a>; </li><li><a href="/search/?q=author%3AZheng%2C%20Hui">Zheng, Hui</a>; </li><li><a href="/search/?q=author%3AShe%2C%20Yunlang">She, Yunlang</a>; </li><li><a href="/search/?q=author%3AZhou%2C%20Fangyu">Zhou, Fangyu</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Yue">Wang, Yue</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Pengpeng">Li, Pengpeng</a>; </li><li><a href="/search/?q=author%3AFei%2C%20Ke">Fei, Ke</a>; </li><li><a href="/search/?q=author%3AJiang%2C%20Gening">Jiang, Gening</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Yang">Zhang, Yang</a>; </li><li><a href="/search/?q=author%3ASu%2C%20Bo">Su, Bo</a>; </li><li><a href="/search/?q=author%3ASweet-Cordero%2C%20E%20Alejandro">Sweet-Cordero, E Alejandro</a>; </li><li><a href="/search/?q=author%3ALe%20Tran%2C%20Nhan">Le Tran, Nhan</a>; </li><li><a href="/search/?q=author%3AYang%2C%20Yanan">Yang, Yanan</a>; </li><li><a href="/search/?q=author%3APatel%2C%20Jai%20N">Patel, Jai N</a>; </li><li><a href="/search/?q=author%3ARolfo%2C%20Christian">Rolfo, Christian</a>; </li><li><a href="/search/?q=author%3ARocco%2C%20Gaetano">Rocco, Gaetano</a>; </li><li><a href="/search/?q=author%3ACardona%2C%20Andr%C3%A9s%20Felipe">Cardona, Andrés Felipe</a>; </li><li><a href="/search/?q=author%3ATuzi%2C%20Alessandro">Tuzi, Alessandro</a>; </li><li><a href="/search/?q=author%3ASuter%2C%20Matteo%20B">Suter, Matteo B</a>; </li><li><a href="/search/?q=author%3AYang%2C%20Ping">Yang, Ping</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Wayne">Xu, Wayne</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AChen%2C%20Chang">Chen, Chang</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2019)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><b>Objective:</b> Synchronous multiple ground-glass nodules (SM-GGNs) are a distinct entity of lung cancer which has been emerging increasingly in recent years in China. The oncogenesis molecular mechanisms of SM-GGNs remain elusive. <b>Methods:</b> We investigated single nucleotide variations (SNV), insertions and deletions (INDEL), somatic copy number variations (CNV), and germline mutations of 69 SM-GGN samples collected from 31 patients, using target sequencing (TRS) and whole exome sequencing (WES). <b>Results:</b> In the entire cohort, many known driver mutations were found, including <i>EGFR</i> (21.7%), <i>BRAF</i> (14.5%), and <i>KRAS</i> (6%). However, only one out of the 31 patients had the same somatic missense or truncated events within SM-GGNs, indicating the independent origins for almost all of these SM-GGNs. Many germline mutations with a low frequency in the Chinese population, and genes harboring both germline and somatic variations, were discovered in these pre-stage GGNs. These GGNs also bore large segments of copy number gains and/or losses. The CNV segment number tended to be positively correlated with the germline mutations (<i>r</i> = 0.57). The CNV sizes were correlated with the somatic mutations (<i>r</i> = 0.55). A moderate correlation (<i>r</i> = 0.54) was also shown between the somatic and germline mutations. <b>Conclusion:</b> Our data suggests that the precancerous unstable CNVs with potentially predisposing genetic backgrounds may foster the onset of driver mutations and the development of independent SM-GGNs during the local stimulation of mutagens.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/9nq1d9g6"><img src="/cms-assets/956f311296a0526041af71100e2e2e8724837af4c677ed07fcfc177deccd68af" alt="Cover page: Germline Predisposition and Copy Number Alteration in Pre-stage Lung Adenocarcinomas Presenting as Ground-Glass Nodules"/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/0hv6s32x"><div class="c-clientmarkup">The Society for Translational Medicine: clinical practice guidelines for the postoperative management of chest tube for patients undergoing lobectomy.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AGao%2C%20Shugeng">Gao, Shugeng</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Zhongheng">Zhang, Zhongheng</a>; </li><li><a href="/search/?q=author%3AArag%C3%B3n%2C%20Javier">Aragón, Javier</a>; </li><li><a href="/search/?q=author%3ABrunelli%2C%20Alessandro">Brunelli, Alessandro</a>; </li><li><a href="/search/?q=author%3ACassivi%2C%20Stephen">Cassivi, Stephen</a>; </li><li><a href="/search/?q=author%3AChai%2C%20Ying">Chai, Ying</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Chang">Chen, Chang</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Chun">Chen, Chun</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Gang">Chen, Gang</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Haiquan">Chen, Haiquan</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Jin-Shing">Chen, Jin-Shing</a>; </li><li><a href="/search/?q=author%3ACooke%2C%20David">Cooke, David</a>; </li><li><a href="/search/?q=author%3ADowns%2C%20John">Downs, John</a>; </li><li><a href="/search/?q=author%3AFalcoz%2C%20Pierre-Emmanuel">Falcoz, Pierre-Emmanuel</a>; </li><li><a href="/search/?q=author%3AFang%2C%20Wentao">Fang, Wentao</a>; </li><li><a href="/search/?q=author%3AFilosso%2C%20Pier">Filosso, Pier</a>; </li><li><a href="/search/?q=author%3AFu%2C%20Xiangning">Fu, Xiangning</a>; </li><li><a href="/search/?q=author%3AForce%2C%20Seth">Force, Seth</a>; </li><li><a href="/search/?q=author%3AGarutti%2C%20Mart%C3%ADnez">Garutti, Martínez</a>; </li><li><a href="/search/?q=author%3AGonzalez-Rivas%2C%20Diego">Gonzalez-Rivas, Diego</a>; </li><li><a href="/search/?q=author%3AGossot%2C%20Dominique">Gossot, Dominique</a>; </li><li><a href="/search/?q=author%3AHansen%2C%20Henrik">Hansen, Henrik</a>; </li><li><a href="/search/?q=author%3AHe%2C%20Jianxing">He, Jianxing</a>; </li><li><a href="/search/?q=author%3AHe%2C%20Jie">He, Jie</a>; </li><li><a href="/search/?q=author%3AHolbek%2C%20Bo">Holbek, Bo</a>; </li><li><a href="/search/?q=author%3AHu%2C%20Jian">Hu, Jian</a>; </li><li><a href="/search/?q=author%3AHuang%2C%20Yunchao">Huang, Yunchao</a>; </li><li><a href="/search/?q=author%3AIbrahim%2C%20Mohsen">Ibrahim, Mohsen</a>; </li><li><a href="/search/?q=author%3AImperatori%2C%20Andrea">Imperatori, Andrea</a>; </li><li><a href="/search/?q=author%3AIsmail%2C%20Mahmoud">Ismail, Mahmoud</a>; </li><li><a href="/search/?q=author%3AJiang%2C%20Gening">Jiang, Gening</a>; </li><li><a href="/search/?q=author%3AJiang%2C%20Hongjing">Jiang, Hongjing</a>; </li><li><a href="/search/?q=author%3AJiang%2C%20Zhongmin">Jiang, Zhongmin</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Hyun">Kim, Hyun</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Danqing">Li, Danqing</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Gaofeng">Li, Gaofeng</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Hui">Li, Hui</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Qiang">Li, Qiang</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Xiaofei">Li, Xiaofei</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Yin">Li, Yin</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Zhijun">Li, Zhijun</a>; </li><li><a href="/search/?q=author%3ALim%2C%20Eric">Lim, Eric</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Chia-Chuan">Liu, Chia-Chuan</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Deruo">Liu, Deruo</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Lunxu">Liu, Lunxu</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Yongyi">Liu, Yongyi</a>; </li><li><a href="/search/?q=author%3ALobdell%2C%20Kevin">Lobdell, Kevin</a>; </li><li><a href="/search/?q=author%3AMa%2C%20Haitao">Ma, Haitao</a>; </li><li><a href="/search/?q=author%3AMao%2C%20Weimin">Mao, Weimin</a>; </li><li><a href="/search/?q=author%3AMao%2C%20Yousheng">Mao, Yousheng</a>; </li><li><a href="/search/?q=author%3AMou%2C%20Juwei">Mou, Juwei</a>; </li><li><a href="/search/?q=author%3ANg%2C%20Calvin">Ng, Calvin</a>; </li><li><a href="/search/?q=author%3ANovoa%2C%20Nuria">Novoa, Nuria</a>; </li><li><a href="/search/?q=author%3APetersen%2C%20Ren%C3%A9">Petersen, René</a>; </li><li><a href="/search/?q=author%3AOizumi%2C%20Hiroyuki">Oizumi, Hiroyuki</a>; </li><li><a href="/search/?q=author%3APapagiannopoulos%2C%20Kostas">Papagiannopoulos, Kostas</a>; </li><li><a href="/search/?q=author%3APompili%2C%20Cecilia">Pompili, Cecilia</a>; </li><li><a href="/search/?q=author%3AQiao%2C%20Guibin">Qiao, Guibin</a>; </li><li><a href="/search/?q=author%3ARefai%2C%20Majed">Refai, Majed</a>; </li><li><a href="/search/?q=author%3ARocco%2C%20Gaetano">Rocco, Gaetano</a>; </li><li><a href="/search/?q=author%3ARuffini%2C%20Erico">Ruffini, Erico</a>; </li><li><a href="/search/?q=author%3ASalati%2C%20Michele">Salati, Michele</a>; </li><li><a href="/search/?q=author%3ASeguin-Givelet%2C%20Agathe">Seguin-Givelet, Agathe</a>; </li><li><a href="/search/?q=author%3ASihoe%2C%20Alan">Sihoe, Alan</a>; </li><li><a href="/search/?q=author%3ATan%2C%20Lijie">Tan, Lijie</a>; </li><li><a href="/search/?q=author%3ATan%2C%20Qunyou">Tan, Qunyou</a>; </li><li><a href="/search/?q=author%3ATong%2C%20Tang">Tong, Tang</a>; </li><li><a href="/search/?q=author%3ATsakiridis%2C%20Kosmas">Tsakiridis, Kosmas</a>; </li><li><a href="/search/?q=author%3AVenuta%2C%20Federico">Venuta, Federico</a>; </li><li><a href="/search/?q=author%3AVeronesi%2C%20Giulia">Veronesi, Giulia</a>; </li><li><a href="/search/?q=author%3AVillamizar%2C%20Nestor">Villamizar, Nestor</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Haidong">Wang, Haidong</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Qun">Wang, Qun</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Ruwen">Wang, Ruwen</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Shumin">Wang, Shumin</a>; </li><li><a href="/search/?q=author%3AWright%2C%20Gavin">Wright, Gavin</a>; </li><li><a href="/search/?q=author%3AXie%2C%20Deyao">Xie, Deyao</a>; </li><li><a href="/search/?q=author%3AXue%2C%20Qi">Xue, Qi</a>; </li><li><a href="/search/?q=author%3AXue%2C%20Tao">Xue, Tao</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Lin">Xu, Lin</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Shidong">Xu, Shidong</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Songtao">Xu, Songtao</a>; </li><li><a href="/search/?q=author%3AYan%2C%20Tiansheng">Yan, Tiansheng</a>; </li><li><a href="/search/?q=author%3AYu%2C%20Fenglei">Yu, Fenglei</a>; </li><li><a href="/search/?q=author%3AYu%2C%20Zhentao">Yu, Zhentao</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Chunfang">Zhang, Chunfang</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Lanjun">Zhang, Lanjun</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Tao">Zhang, Tao</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Xun">Zhang, Xun</a>; </li><li><a href="/search/?q=author%3AZhao%2C%20Xiaojing">Zhao, Xiaojing</a>; </li><li><a href="/search/?q=author%3AZhao%2C%20Xuewei">Zhao, Xuewei</a>; </li><li><a href="/search/?q=author%3AZhi%2C%20Xiuyi">Zhi, Xiuyi</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AZhou%2C%20Qinghua">Zhou, Qinghua</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucd_postprints">UC Davis Previously Published Works</a> (2017)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">The Society for Translational Medicine and The Chinese Society for Thoracic and Cardiovascular Surgery conducted a systematic review of the literature in an attempt to improve our understanding in the postoperative management of chest tubes of patients undergoing pulmonary lobectomy. Recommendations were produced and classified based on an internationally accepted GRADE system. The following recommendations were extracted in the present review: (I) chest tubes can be removed safely with daily pleural fluid of up to 450 mL (non-chylous and non-sanguinous), which may reduce chest tube duration and hospital length of stay (2B); (II) in rare instances, e.g., persistent abundant fluid production, the use of PrRP/B <0.5 when evaluating fluid output to determine chest tube removal might be beneficial (2B); (III) it is recommended that one chest tube is adequate following pulmonary lobectomy, except for hemorrhage and space problems (2A); (IV) chest tube clearance by milking and stripping is not recommended after lung resection (2B); (V) chest tube suction is not necessary for patients undergoing lobectomy after first postoperative day (2A); (VI) regulated chest tube suction [-11 (-1.08 kPa) to -20 (1.96 kPa) cmH2O depending upon the type of lobectomy] is not superior to regulated seal [-2 (0.196 kPa) cmH2O] when electronic drainage systems are used after lobectomy by thoracotomy (2B); (VII) chest tube removal recommended at the end of expiration and may be slightly superior to removal at the end of inspiration (2A); (VIII) electronic drainage systems are recommended in the management of chest tube in patients undergoing lobectomy (2B).</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/0hv6s32x"><img src="/cms-assets/806489c78f75b02e4dfe8776cf5bdd5f148ed79844aa5c57fdf416e5e409032f" alt="Cover page: The Society for Translational Medicine: clinical practice guidelines for the postoperative management of chest tube for patients undergoing lobectomy."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/4j92v56r"><div class="c-clientmarkup">Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AShi%2C%20Jianxin">Shi, Jianxin</a>; </li><li><a href="/search/?q=author%3AShiraishi%2C%20Kouya">Shiraishi, Kouya</a>; </li><li><a href="/search/?q=author%3AChoi%2C%20Jiyeon">Choi, Jiyeon</a>; </li><li><a href="/search/?q=author%3AMatsuo%2C%20Keitaro">Matsuo, Keitaro</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Tzu-Yu">Chen, Tzu-Yu</a>; </li><li><a href="/search/?q=author%3ADai%2C%20Juncheng">Dai, Juncheng</a>; </li><li><a href="/search/?q=author%3AHung%2C%20Rayjean%20J">Hung, Rayjean J</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Kexin">Chen, Kexin</a>; </li><li><a href="/search/?q=author%3AShu%2C%20Xiao-Ou">Shu, Xiao-Ou</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Young%20Tae">Kim, Young Tae</a>; </li><li><a href="/search/?q=author%3ALandi%2C%20Maria%20Teresa">Landi, Maria Teresa</a>; </li><li><a href="/search/?q=author%3ALin%2C%20Dongxin">Lin, Dongxin</a>; </li><li><a href="/search/?q=author%3AZheng%2C%20Wei">Zheng, Wei</a>; </li><li><a href="/search/?q=author%3AYin%2C%20Zhihua">Yin, Zhihua</a>; </li><li><a href="/search/?q=author%3AZhou%2C%20Baosen">Zhou, Baosen</a>; </li><li><a href="/search/?q=author%3ASong%2C%20Bao">Song, Bao</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Jiucun">Wang, Jiucun</a>; </li><li><a href="/search/?q=author%3ASeow%2C%20Wei%20Jie">Seow, Wei Jie</a>; </li><li><a href="/search/?q=author%3ASong%2C%20Lei">Song, Lei</a>; </li><li><a href="/search/?q=author%3AChang%2C%20I-Shou">Chang, I-Shou</a>; </li><li><a href="/search/?q=author%3AHu%2C%20Wei">Hu, Wei</a>; </li><li><a href="/search/?q=author%3AChien%2C%20Li-Hsin">Chien, Li-Hsin</a>; </li><li><a href="/search/?q=author%3ACai%2C%20Qiuyin">Cai, Qiuyin</a>; </li><li><a href="/search/?q=author%3AHong%2C%20Yun-Chul">Hong, Yun-Chul</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Hee%20Nam">Kim, Hee Nam</a>; </li><li><a href="/search/?q=author%3AWu%2C%20Yi-Long">Wu, Yi-Long</a>; </li><li><a href="/search/?q=author%3AWong%2C%20Maria%20Pik">Wong, Maria Pik</a>; </li><li><a href="/search/?q=author%3ARichardson%2C%20Brian%20Douglas">Richardson, Brian Douglas</a>; </li><li><a href="/search/?q=author%3AFunderburk%2C%20Karen%20M">Funderburk, Karen M</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Shilan">Li, Shilan</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Tongwu">Zhang, Tongwu</a>; </li><li><a href="/search/?q=author%3ABreeze%2C%20Charles">Breeze, Charles</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Zhaoming">Wang, Zhaoming</a>; </li><li><a href="/search/?q=author%3ABlechter%2C%20Batel">Blechter, Batel</a>; </li><li><a href="/search/?q=author%3ABassig%2C%20Bryan%20A">Bassig, Bryan A</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Jin%20Hee">Kim, Jin Hee</a>; </li><li><a href="/search/?q=author%3AAlbanes%2C%20Demetrius">Albanes, Demetrius</a>; </li><li><a href="/search/?q=author%3AWong%2C%20Jason%20YY">Wong, Jason YY</a>; </li><li><a href="/search/?q=author%3AShin%2C%20Min-Ho">Shin, Min-Ho</a>; </li><li><a href="/search/?q=author%3AChung%2C%20Lap%20Ping">Chung, Lap Ping</a>; </li><li><a href="/search/?q=author%3AYang%2C%20Yang">Yang, Yang</a>; </li><li><a href="/search/?q=author%3AAn%2C%20She-Juan">An, She-Juan</a>; </li><li><a href="/search/?q=author%3AZheng%2C%20Hong">Zheng, Hong</a>; </li><li><a href="/search/?q=author%3AYatabe%2C%20Yasushi">Yatabe, Yasushi</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Xu-Chao">Zhang, Xu-Chao</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Young-Chul">Kim, Young-Chul</a>; </li><li><a href="/search/?q=author%3ACaporaso%2C%20Neil%20E">Caporaso, Neil E</a>; </li><li><a href="/search/?q=author%3AChang%2C%20Jiang">Chang, Jiang</a>; </li><li><a href="/search/?q=author%3AHo%2C%20James%20Chung%20Man">Ho, James Chung Man</a>; </li><li><a href="/search/?q=author%3AKubo%2C%20Michiaki">Kubo, Michiaki</a>; </li><li><a href="/search/?q=author%3ADaigo%2C%20Yataro">Daigo, Yataro</a>; </li><li><a href="/search/?q=author%3ASong%2C%20Minsun">Song, Minsun</a>; </li><li><a href="/search/?q=author%3AMomozawa%2C%20Yukihide">Momozawa, Yukihide</a>; </li><li><a href="/search/?q=author%3AKamatani%2C%20Yoichiro">Kamatani, Yoichiro</a>; </li><li><a href="/search/?q=author%3AKobayashi%2C%20Masashi">Kobayashi, Masashi</a>; </li><li><a href="/search/?q=author%3AOkubo%2C%20Kenichi">Okubo, Kenichi</a>; </li><li><a href="/search/?q=author%3AHonda%2C%20Takayuki">Honda, Takayuki</a>; </li><li><a href="/search/?q=author%3AHosgood%2C%20Dean%20H">Hosgood, Dean H</a>; </li><li><a href="/search/?q=author%3AKunitoh%2C%20Hideo">Kunitoh, Hideo</a>; </li><li><a href="/search/?q=author%3APatel%2C%20Harsh">Patel, Harsh</a>; </li><li><a href="/search/?q=author%3AWatanabe%2C%20Shun-ichi">Watanabe, Shun-ichi</a>; </li><li><a href="/search/?q=author%3AMiyagi%2C%20Yohei">Miyagi, Yohei</a>; </li><li><a href="/search/?q=author%3ANakayama%2C%20Haruhiko">Nakayama, Haruhiko</a>; </li><li><a href="/search/?q=author%3AMatsumoto%2C%20Shingo">Matsumoto, Shingo</a>; </li><li><a href="/search/?q=author%3AHorinouchi%2C%20Hidehito">Horinouchi, Hidehito</a>; </li><li><a href="/search/?q=author%3ATsuboi%2C%20Masahiro">Tsuboi, Masahiro</a>; </li><li><a href="/search/?q=author%3AHamamoto%2C%20Ryuji">Hamamoto, Ryuji</a>; </li><li><a href="/search/?q=author%3AGoto%2C%20Koichi">Goto, Koichi</a>; </li><li><a href="/search/?q=author%3AOhe%2C%20Yuichiro">Ohe, Yuichiro</a>; </li><li><a href="/search/?q=author%3ATakahashi%2C%20Atsushi">Takahashi, Atsushi</a>; </li><li><a href="/search/?q=author%3AGoto%2C%20Akiteru">Goto, Akiteru</a>; </li><li><a href="/search/?q=author%3AMinamiya%2C%20Yoshihiro">Minamiya, Yoshihiro</a>; </li><li><a href="/search/?q=author%3AHara%2C%20Megumi">Hara, Megumi</a>; </li><li><a href="/search/?q=author%3ANishida%2C%20Yuichiro">Nishida, Yuichiro</a>; </li><li><a href="/search/?q=author%3ATakeuchi%2C%20Kenji">Takeuchi, Kenji</a>; </li><li><a href="/search/?q=author%3AWakai%2C%20Kenji">Wakai, Kenji</a>; </li><li><a href="/search/?q=author%3AMatsuda%2C%20Koichi">Matsuda, Koichi</a>; </li><li><a href="/search/?q=author%3AMurakami%2C%20Yoshinori">Murakami, Yoshinori</a>; </li><li><a href="/search/?q=author%3AShimizu%2C%20Kimihiro">Shimizu, Kimihiro</a>; </li><li><a href="/search/?q=author%3ASuzuki%2C%20Hiroyuki">Suzuki, Hiroyuki</a>; </li><li><a href="/search/?q=author%3ASaito%2C%20Motonobu">Saito, Motonobu</a>; </li><li><a href="/search/?q=author%3AOhtaki%2C%20Yoichi">Ohtaki, Yoichi</a>; </li><li><a href="/search/?q=author%3ATanaka%2C%20Kazumi">Tanaka, Kazumi</a>; </li><li><a href="/search/?q=author%3AWu%2C%20Tangchun">Wu, Tangchun</a>; </li><li><a href="/search/?q=author%3AWei%2C%20Fusheng">Wei, Fusheng</a>; </li><li><a href="/search/?q=author%3ADai%2C%20Hongji">Dai, Hongji</a>; </li><li><a href="/search/?q=author%3AMachiela%2C%20Mitchell%20J">Machiela, Mitchell J</a>; </li><li><a href="/search/?q=author%3ASu%2C%20Jian">Su, Jian</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Yeul%20Hong">Kim, Yeul Hong</a>; </li><li><a href="/search/?q=author%3AOh%2C%20In-Jae">Oh, In-Jae</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Victor%20Ho%20Fun">Lee, Victor Ho Fun</a>; </li><li><a href="/search/?q=author%3AChang%2C%20Gee-Chen">Chang, Gee-Chen</a>; </li><li><a href="/search/?q=author%3ATsai%2C%20Ying-Huang">Tsai, Ying-Huang</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Kuan-Yu">Chen, Kuan-Yu</a>; </li><li><a href="/search/?q=author%3AHuang%2C%20Ming-Shyan">Huang, Ming-Shyan</a>; </li><li><a href="/search/?q=author%3ASu%2C%20Wu-Chou">Su, Wu-Chou</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Yuh-Min">Chen, Yuh-Min</a>; </li><li><a href="/search/?q=author%3ASeow%2C%20Adeline">Seow, Adeline</a>; </li><li><a href="/search/?q=author%3APark%2C%20Jae%20Yong">Park, Jae Yong</a>; </li><li><a href="/search/?q=author%3AKweon%2C%20Sun-Seog">Kweon, Sun-Seog</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Kun-Chieh">Chen, Kun-Chieh</a>; </li><li><a href="/search/?q=author%3AGao%2C%20Yu-Tang">Gao, Yu-Tang</a>; </li><li><a href="/search/?q=author%3AQian%2C%20Biyun">Qian, Biyun</a>; </li><li><a href="/search/?q=author%3AWu%2C%20Chen">Wu, Chen</a>; </li><li><a href="/search/?q=author%3ALu%2C%20Daru">Lu, Daru</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Jianjun">Liu, Jianjun</a>; </li><li><a href="/search/?q=author%3ASchwartz%2C%20Ann%20G">Schwartz, Ann G</a>; </li><li><a href="/search/?q=author%3AHoulston%2C%20Richard">Houlston, Richard</a>; </li><li><a href="/search/?q=author%3ASpitz%2C%20Margaret%20R">Spitz, Margaret R</a>; </li><li><a href="/search/?q=author%3AGorlov%2C%20Ivan%20P">Gorlov, Ivan P</a>; </li><li><a href="/search/?q=author%3AWu%2C%20Xifeng">Wu, Xifeng</a>; </li><li><a href="/search/?q=author%3AYang%2C%20Ping">Yang, Ping</a>; </li><li><a href="/search/?q=author%3ALam%2C%20Stephen">Lam, Stephen</a>; </li><li><a href="/search/?q=author%3ATardon%2C%20Adonina">Tardon, Adonina</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Chu">Chen, Chu</a>; </li><li><a href="/search/?q=author%3ABojesen%2C%20Stig%20E">Bojesen, Stig E</a>; </li><li><a href="/search/?q=author%3AJohansson%2C%20Mattias">Johansson, Mattias</a>; </li><li><a href="/search/?q=author%3ARisch%2C%20Angela">Risch, Angela</a>; </li><li><a href="/search/?q=author%3ABickeb%C3%B6ller%2C%20Heike">Bickeböller, Heike</a>; </li><li><a href="/search/?q=author%3AJi%2C%20Bu-Tian">Ji, Bu-Tian</a>; </li><li><a href="/search/?q=author%3AWichmann%2C%20H-Erich">Wichmann, H-Erich</a>; </li><li><a href="/search/?q=author%3AChristiani%2C%20David%20C">Christiani, David C</a>; </li><li><a href="/search/?q=author%3ARennert%2C%20Gadi">Rennert, Gadi</a>; </li><li><a href="/search/?q=author%3AArnold%2C%20Susanne">Arnold, Susanne</a>; </li><li><a href="/search/?q=author%3ABrennan%2C%20Paul">Brennan, Paul</a>; </li><li><a href="/search/?q=author%3AMcKay%2C%20James">McKay, James</a>; </li><li><a href="/search/?q=author%3AField%2C%20John%20K">Field, John K</a>; </li><li><a href="/search/?q=author%3AShete%2C%20Sanjay%20S">Shete, Sanjay S</a>; </li><li><a href="/search/?q=author%3ALe%20Marchand%2C%20Loic">Le Marchand, Loic</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Geoffrey">Liu, Geoffrey</a>; </li><li><a href="/search/?q=author%3AAndrew%2C%20Angeline">Andrew, Angeline</a>; </li><li><a href="/search/?q=author%3AKiemeney%2C%20Lambertus%20A">Kiemeney, Lambertus A</a>; </li><li><a href="/search/?q=author%3AZienolddiny-Narui%2C%20Shan">Zienolddiny-Narui, Shan</a>; </li><li><a href="/search/?q=author%3AGrankvist%2C%20Kjell">Grankvist, Kjell</a>; </li><li><a href="/search/?q=author%3AJohansson%2C%20Mikael">Johansson, Mikael</a>; </li><li><a href="/search/?q=author%3ACox%2C%20Angela">Cox, Angela</a>; </li><li><a href="/search/?q=author%3ATaylor%2C%20Fiona">Taylor, Fiona</a>; </li><li><a href="/search/?q=author%3AYuan%2C%20Jian-Min">Yuan, Jian-Min</a>; </li><li><a href="/search/?q=author%3ALazarus%2C%20Philip">Lazarus, Philip</a>; </li><li><a href="/search/?q=author%3ASchabath%2C%20Matthew%20B">Schabath, Matthew B</a>; </li><li><a href="/search/?q=author%3AAldrich%2C%20Melinda%20C">Aldrich, Melinda C</a>; </li><li><a href="/search/?q=author%3AJeon%2C%20Hyo-Sung">Jeon, Hyo-Sung</a>; </li><li><a href="/search/?q=author%3AJiang%2C%20Shih%20Sheng">Jiang, Shih Sheng</a>; </li><li><a href="/search/?q=author%3ASung%2C%20Jae%20Sook">Sung, Jae Sook</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Chung-Hsing">Chen, Chung-Hsing</a>; </li><li><a href="/search/?q=author%3AHsiao%2C%20Chin-Fu">Hsiao, Chin-Fu</a>; </li><li><a href="/search/?q=author%3AJung%2C%20Yoo%20Jin">Jung, Yoo Jin</a>; </li><li><a href="/search/?q=author%3AGuo%2C%20Huan">Guo, Huan</a>; </li><li><a href="/search/?q=author%3AHu%2C%20Zhibin">Hu, Zhibin</a>; </li><li><a href="/search/?q=author%3ABurdett%2C%20Laurie">Burdett, Laurie</a>; </li><li><a href="/search/?q=author%3AYeager%2C%20Meredith">Yeager, Meredith</a>; </li><li><a href="/search/?q=author%3AHutchinson%2C%20Amy">Hutchinson, Amy</a>; </li><li><a href="/search/?q=author%3AHicks%2C%20Belynda">Hicks, Belynda</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Jia">Liu, Jia</a>; </li><li><a href="/search/?q=author%3AZhu%2C%20Bin">Zhu, Bin</a>; </li><li><a href="/search/?q=author%3ABerndt%2C%20Sonja%20I">Berndt, Sonja I</a>; </li><li><a href="/search/?q=author%3AWu%2C%20Wei">Wu, Wei</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Junwen">Wang, Junwen</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Yuqing">Li, Yuqing</a>; </li><li><a href="/search/?q=author%3AChoi%2C%20Jin%20Eun">Choi, Jin Eun</a>; </li><li><a href="/search/?q=author%3APark%2C%20Kyong%20Hwa">Park, Kyong Hwa</a>; </li><li><a href="/search/?q=author%3ASung%2C%20Sook%20Whan">Sung, Sook Whan</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Li">Liu, Li</a>; </li><li><a href="/search/?q=author%3AKang%2C%20Chang%20Hyun">Kang, Chang Hyun</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Wen-Chang">Wang, Wen-Chang</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Jun">Xu, Jun</a>; </li><li><a href="/search/?q=author%3AGuan%2C%20Peng">Guan, Peng</a>; </li><li><a href="/search/?q=author%3ATan%2C%20Wen">Tan, Wen</a>; </li><li><a href="/search/?q=author%3AYu%2C%20Chong-Jen">Yu, Chong-Jen</a>; </li><li><a href="/search/?q=author%3AYang%2C%20Gong">Yang, Gong</a>; </li><li><a href="/search/?q=author%3ASihoe%2C%20Alan%20Dart%20Loon">Sihoe, Alan Dart Loon</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Ying">Chen, Ying</a>; </li><li><a href="/search/?q=author%3AChoi%2C%20Yi%20Young">Choi, Yi Young</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Jun%20Suk">Kim, Jun Suk</a>; </li><li><a href="/search/?q=author%3AYoon%2C%20Ho-Il">Yoon, Ho-Il</a>; </li><li><a href="/search/?q=author%3APark%2C%20In%20Kyu">Park, In Kyu</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Ping">Xu, Ping</a>; </li><li><a href="/search/?q=author%3AHe%2C%20Qincheng">He, Qincheng</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Chih-Liang">Wang, Chih-Liang</a>; </li><li><a href="/search/?q=author%3AHung%2C%20Hsiao-Han">Hung, Hsiao-Han</a>; </li><li><a href="/search/?q=author%3AVermeulen%2C%20Roel%20CH">Vermeulen, Roel CH</a>; </li><li><a href="/search/?q=author%3ACheng%2C%20Iona">Cheng, Iona</a>; </li><li><a href="/search/?q=author%3AWu%2C%20Junjie">Wu, Junjie</a>; </li><li><a href="/search/?q=author%3ALim%2C%20Wei-Yen">Lim, Wei-Yen</a>; </li><li><a href="/search/?q=author%3ATsai%2C%20Fang-Yu">Tsai, Fang-Yu</a>; </li><li><a href="/search/?q=author%3AChan%2C%20John%20KC">Chan, John KC</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Jihua">Li, Jihua</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Hongyan">Chen, Hongyan</a>; </li><li><a href="/search/?q=author%3ALin%2C%20Hsien-Chih">Lin, Hsien-Chih</a>; </li><li><a href="/search/?q=author%3AJin%2C%20Li">Jin, Li</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Jie">Liu, Jie</a>; </li><li><a href="/search/?q=author%3ASawada%2C%20Norie">Sawada, Norie</a>; </li><li><a href="/search/?q=author%3AYamaji%2C%20Taiki">Yamaji, Taiki</a>; </li><li><a href="/search/?q=author%3AWyatt%2C%20Kathleen">Wyatt, Kathleen</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Shengchao%20A">Li, Shengchao A</a>; </li><li><a href="/search/?q=author%3AMa%2C%20Hongxia">Ma, Hongxia</a>; </li><li><a href="/search/?q=author%3AZhu%2C%20Meng">Zhu, Meng</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Zhehai">Wang, Zhehai</a>; </li><li><a href="/search/?q=author%3ACheng%2C%20Sensen">Cheng, Sensen</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Xuelian">Li, Xuelian</a>; </li><li><a href="/search/?q=author%3ARen%2C%20Yangwu">Ren, Yangwu</a>; </li><li><a href="/search/?q=author%3AChao%2C%20Ann">Chao, Ann</a>; </li><li><a href="/search/?q=author%3AIwasaki%2C%20Motoki">Iwasaki, Motoki</a>; </li><li><a href="/search/?q=author%3AZhu%2C%20Junjie">Zhu, Junjie</a>; </li><li><a href="/search/?q=author%3AJiang%2C%20Gening">Jiang, Gening</a>; </li><li><a href="/search/?q=author%3AFei%2C%20Ke">Fei, Ke</a>; </li><li><a href="/search/?q=author%3AWu%2C%20Guoping">Wu, Guoping</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Chih-Yi">Chen, Chih-Yi</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Chien-Jen">Chen, Chien-Jen</a>; </li><li><a href="/search/?q=author%3AYang%2C%20Pan-Chyr">Yang, Pan-Chyr</a>; </li><li><a href="/search/?q=author%3AYu%2C%20Jinming">Yu, Jinming</a>; </li><li><a href="/search/?q=author%3AStevens%2C%20Victoria%20L">Stevens, Victoria L</a>; </li><li><a href="/search/?q=author%3AFraumeni%2C%20Joseph%20F">Fraumeni, Joseph F</a>; </li><li><a href="/search/?q=author%3AChatterjee%2C%20Nilanjan">Chatterjee, Nilanjan</a>; </li><li><a href="/search/?q=author%3AGorlova%2C%20Olga%20Y">Gorlova, Olga Y</a>; </li><li><a href="/search/?q=author%3AHsiung%2C%20Chao%20Agnes">Hsiung, Chao Agnes</a>; </li><li><a href="/search/?q=author%3AAmos%2C%20Christopher%20I">Amos, Christopher I</a>; </li><li><a href="/search/?q=author%3AShen%2C%20Hongbing">Shen, Hongbing</a>; </li><li><a href="/search/?q=author%3AChanock%2C%20Stephen%20J">Chanock, Stephen J</a>; </li><li><a href="/search/?q=author%3ARothman%2C%20Nathaniel">Rothman, Nathaniel</a>; </li><li><a href="/search/?q=author%3AKohno%2C%20Takashi">Kohno, Takashi</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ALan%2C%20Qing">Lan, Qing</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2023)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P<sub>interaction</sub> = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/4j92v56r"><img src="/cms-assets/b0e4848374a2161b6ec421d8b6c116161d75cd0c78d3d92be70d75a6458e97d8" alt="Cover page: Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population"/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section></section></main></form></div><div><div class="c-toplink"><a href="javascript:window.scrollTo(0, 0)">Top</a></div><footer class="c-footer"><nav class="c-footer__nav"><ul><li><a href="/">Home</a></li><li><a href="/aboutEschol">About eScholarship</a></li><li><a href="/campuses">Campus Sites</a></li><li><a href="/ucoapolicies">UC Open Access Policy</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="https://www.cdlib.org/about/accessibility.html">Accessibility</a></li><li><a href="/privacypolicy">Privacy Statement</a></li><li><a href="/policies">Site Policies</a></li><li><a href="/terms">Terms of Use</a></li><li><a href="/login"><strong>Admin Login</strong></a></li><li><a href="https://help.escholarship.org"><strong>Help</strong></a></li></ul></nav><div class="c-footer__logo"><a href="/"><img class="c-lazyimage" data-src="/images/logo_footer-eschol.svg" alt="eScholarship, University of California"/></a></div><div class="c-footer__copyright">Powered by the<br/><a href="http://www.cdlib.org">California Digital Library</a><br/>Copyright © 2017<br/>The Regents of the University of California</div></footer></div></div></div></div> <script src="/js/vendors~app-bundle-2aefc956e545366a5d4e.js"></script> <script src="/js/app-bundle-3c8ebc2ec05dcc3202fd.js"></script> </body> </html>