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class="elementor-item menu-link" tabindex="-1">Contact us</a></li> </ul> </nav> </div> </div> </div> </div> </div> </section> </div> <div id="content" class="site-content"> <div class="ast-container"> <div id="primary" class="content-area primary"> <main id="main" class="site-main"> <article class="post-11424 page type-page status-publish ast-article-single" id="post-11424" itemtype="https://schema.org/CreativeWork" itemscope="itemscope"> <header class="entry-header ast-no-title ast-header-without-markup"> </header>  <div class="entry-content clear" itemprop="text"> <div data-elementor-type="wp-page" data-elementor-id="11424" class="elementor elementor-11424" data-elementor-post-type="page"> <section data-dce-background-overlay-color="#FFFFFF00" data-dce-background-image-url="https://www.lhasalimited.org/wp-content/uploads/2022/11/solutions-banner-v2-scaled.jpg" class="elementor-section elementor-top-section elementor-element elementor-element-4d2653a0 elementor-section-height-min-height elementor-section-items-top elementor-section-boxed elementor-section-height-default" data-id="4d2653a0" data-element_type="section" data-settings="{"background_background":"classic","jet_parallax_layout_list":[]}"> <div class="elementor-background-overlay"></div> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-202dae80" data-id="202dae80" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-cd63b29 elementor-widget elementor-widget-heading" data-id="cd63b29" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h1 class="elementor-heading-title elementor-size-default">Genotoxic impurity evaluation</h1> </div> </div> <div class="elementor-element elementor-element-605ce563 elementor-widget elementor-widget-text-editor" data-id="605ce563" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span class="TextRun SCXW193436818 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW193436818 BCX8">Ensuring effective assessment and management of </span><span class="NormalTextRun SCXW193436818 BCX8">your </span><span class="NormalTextRun SCXW193436818 BCX8">mutagenic and non-mutagenic impurities</span></span></p> </div> </div> <div class="elementor-element elementor-element-371577f7 elementor-widget elementor-widget-button" data-id="371577f7" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="/contact-us"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Get in touch</span> </span> </a> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-65f51ae0" data-id="65f51ae0" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-2b1a5058 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="2b1a5058" data-element_type="section" data-settings="{"background_background":"classic","jet_parallax_layout_list":[]}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-223ebf75" data-id="223ebf75" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <section class="elementor-section elementor-inner-section elementor-element elementor-element-388458ba elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="388458ba" data-element_type="section" data-settings="{"jet_parallax_layout_list":[]}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-23daa42d" data-id="23daa42d" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-29dac82f elementor-widget elementor-widget-text-editor" data-id="29dac82f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span class="TextRun SCXW138906289 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW138906289 BCX8">Assessing the genotoxicity of chemicals presents significant challenges, as the complexity of chemical interactions often leads to uncertain results and potential risks. </span><span class="NormalTextRun SCXW138906289 BCX8">Identifying</span><span class="NormalTextRun SCXW138906289 BCX8"> genotoxic properties early is crucial, yet traditional methods can be time-consuming and costly. Our solutions are designed to streamline this process, offering reliable insights to help you confidently manage genotoxicity assessments, reduce uncertainty and ensure safety in your chemical evaluations.</span></span></p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-43d5339e elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible" data-id="43d5339e" data-element_type="section" data-settings="{"background_background":"classic","jet_parallax_layout_list":[],"animation":"rotateInUpLeft"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7c5841c8" data-id="7c5841c8" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-bbffeb8 elementor-widget elementor-widget-heading" data-id="bbffeb8" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Our solution</h2> </div> </div> <div class="elementor-element elementor-element-3695caf3 elementor-widget elementor-widget-text-editor" data-id="3695caf3" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span class="TextRun SCXW126196060 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW126196060 BCX8">We can support you in your toxicity risk assessment of genotoxic impurities </span><span class="NormalTextRun CommentStart SCXW126196060 BCX8">through</span><span class="NormalTextRun SCXW126196060 BCX8"> our </span></span><em><span class="TextRun SCXW126196060 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW126196060 BCX8">in silico</span></span></em><span class="TextRun SCXW126196060 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW126196060 BCX8"> solutions; Sarah Nexus</span><span class="NormalTextRun SCXW126196060 BCX8">,</span><span class="NormalTextRun SCXW126196060 BCX8"> Derek Nexus</span><span class="NormalTextRun SCXW126196060 BCX8"> and </span><span class="NormalTextRun SpellingErrorV2Themed SCXW126196060 BCX8">Vitic</span><span class="NormalTextRun SCXW126196060 BCX8">. Genotoxicity</span><span class="NormalTextRun SCXW126196060 BCX8"> assessment</span> <span class="NormalTextRun SCXW126196060 BCX8">comprises</span></span><span class="TrackChangeTextDeletionMarker TrackedChange SCXW126196060 BCX8"><span class="TextRun SCXW126196060 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun TrackChangeTextDeletion SCXW126196060 BCX8"> </span></span></span><span class="TextRun SCXW126196060 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW126196060 BCX8">two major endpoints, </span><span class="NormalTextRun SCXW126196060 BCX8">mutagenicity</span><span class="NormalTextRun SCXW126196060 BCX8"> and chromosome damage – our solutions will </span><span class="NormalTextRun SCXW126196060 BCX8">support</span><span class="NormalTextRun SCXW126196060 BCX8"> an assessment of both major genotoxic endpoints</span><span class="NormalTextRun CommentStart SCXW126196060 BCX8">. </span></span><span class="EOP SCXW126196060 BCX8" data-ccp-props="{}"> </span></p> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-7f4a8f2f elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="7f4a8f2f" data-element_type="section" data-settings="{"jet_parallax_layout_list":[],"animation":"none"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-7876dcc0" data-id="7876dcc0" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-44cd439 dce_masking-none elementor-widget elementor-widget-image" data-id="44cd439" data-element_type="widget" data-settings="{"motion_fx_motion_fx_mouse":"yes"}" data-widget_type="image.default"> <div class="elementor-widget-container"> <a href="#Derek"> <img decoding="async" width="2068" height="769" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/sarah-logo.png" class="elementor-animation-hang attachment-full size-full wp-image-2677" alt="sarah logo" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/sarah-logo.png 2068w, https://www.lhasalimited.org/wp-content/uploads/2022/11/sarah-logo-300x112.png 300w, https://www.lhasalimited.org/wp-content/uploads/2022/11/sarah-logo-1024x381.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2022/11/sarah-logo-768x286.png 768w, https://www.lhasalimited.org/wp-content/uploads/2022/11/sarah-logo-1536x571.png 1536w, https://www.lhasalimited.org/wp-content/uploads/2022/11/sarah-logo-2048x762.png 2048w" sizes="(max-width: 2068px) 100vw, 2068px"> </a> </div> </div> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-28b295ab" data-id="28b295ab" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-53d9cd16 dce_masking-none elementor-widget elementor-widget-image" data-id="53d9cd16" data-element_type="widget" data-settings="{"motion_fx_motion_fx_mouse":"yes"}" data-widget_type="image.default"> <div class="elementor-widget-container"> <a href="#Sarah"> <img decoding="async" width="1024" height="381" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-1024x381.png" class="elementor-animation-hang attachment-large size-large wp-image-2667" alt="derek logo" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-1024x381.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-300x112.png 300w, https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-768x286.png 768w, https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-1536x571.png 1536w, https://www.lhasalimited.org/wp-content/uploads/2022/11/derek-logo-2048x762.png 2048w" sizes="(max-width: 1024px) 100vw, 1024px"> </a> </div> </div> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-79fc150b" data-id="79fc150b" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-254dd856 dce_masking-none elementor-widget elementor-widget-image" data-id="254dd856" data-element_type="widget" data-settings="{"motion_fx_motion_fx_mouse":"yes"}" data-widget_type="image.default"> <div class="elementor-widget-container"> <a href="#Vitic"> <img loading="lazy" decoding="async" width="2068" height="769" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1.png" class="elementor-animation-hang attachment-full size-full wp-image-2668" alt="vitic logo 1" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1.png 2068w, https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1-300x112.png 300w, https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1-1024x381.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1-768x286.png 768w, https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1-1536x571.png 1536w, https://www.lhasalimited.org/wp-content/uploads/2022/11/vitic-logo-1-2048x762.png 2048w" sizes="(max-width: 2068px) 100vw, 2068px"> </a> </div> </div> </div> </div> </div> </section> <div class="elementor-element elementor-element-f85732 elementor-widget elementor-widget-menu-anchor" data-id="f85732" data-element_type="widget" data-widget_type="menu-anchor.default"> <div class="elementor-widget-container"> <div class="elementor-menu-anchor" id="Derek"></div> </div> </div> </div> </div> </div> </section> <section data-dce-background-color="#FFFFFF" class="elementor-section elementor-top-section elementor-element elementor-element-3c2124f elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="3c2124f" data-element_type="section" data-settings="{"jet_parallax_layout_list":[],"background_background":"gradient"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-cc7d152" data-id="cc7d152" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-01517d9" data-id="01517d9" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-e918b19 dce_masking-none elementor-widget elementor-widget-image" data-id="e918b19" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="9420" height="3404" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/SARAH_LOGO.png" class="attachment-full size-full wp-image-2404" alt="SARAH LOGO" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/SARAH_LOGO.png 9420w, https://www.lhasalimited.org/wp-content/uploads/2022/11/SARAH_LOGO-300x108.png 300w, https://www.lhasalimited.org/wp-content/uploads/2022/11/SARAH_LOGO-1024x370.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2022/11/SARAH_LOGO-768x278.png 768w, https://www.lhasalimited.org/wp-content/uploads/2022/11/SARAH_LOGO-1536x555.png 1536w, https://www.lhasalimited.org/wp-content/uploads/2022/11/SARAH_LOGO-2048x740.png 2048w" sizes="(max-width: 9420px) 100vw, 9420px"> </div> </div> <div class="elementor-element elementor-element-1e87741 elementor-widget elementor-widget-text-editor" data-id="1e87741" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>Sarah Nexus</strong> is a <span class="NormalTextRun SCXW194932658 BCX8">statistical</span><span class="NormalTextRun SCXW194932658 BCX8">-based software</span><span class="NormalTextRun SCXW194932658 BCX8"> which can help to </span><span class="NormalTextRun SCXW194932658 BCX8">identify</span><span class="NormalTextRun SCXW194932658 BCX8"> genotoxic impurities through the prediction of chromosome damage and mutagenicity.</span></p> </div> </div> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-619ccd1" data-id="619ccd1" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-2ce291c4 elementor-widget elementor-widget-heading" data-id="2ce291c4" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Sarah Nexus highlights</h2> </div> </div> <div class="elementor-element elementor-element-382aa681 elementor-widget elementor-widget-text-editor" data-id="382aa681" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span class="TextRun SCXW2509371 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW2509371 BCX8">Predict </span><span class="NormalTextRun SCXW2509371 BCX8">the potential genetic toxicity of chemicals</span></span><span class="EOP SCXW2509371 BCX8" data-ccp-props="{}"> </span></strong><br /><span class="TextRun SCXW77106795 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW77106795 BCX8">Access Ames assay data for </span><span class="NormalTextRun SCXW77106795 BCX8">accurate</span><span class="NormalTextRun SCXW77106795 BCX8"> mutagenicity predictions,</span></span><span class="TextRun SCXW77106795 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW77106795 BCX8"> and l</span><span class="NormalTextRun SCXW77106795 BCX8">everage micronucleus and chromosome aberration </span></span><em><span class="TextRun SCXW77106795 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW77106795 BCX8">in</span> <span class="NormalTextRun SCXW77106795 BCX8">vitro </span></span></em><span class="TextRun SCXW77106795 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW77106795 BCX8">assay data</span><span class="NormalTextRun SCXW77106795 BCX8"> and </span></span><em><span class="TextRun SCXW77106795 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW77106795 BCX8">in</span> <span class="NormalTextRun SCXW77106795 BCX8">vivo</span></span></em><span class="TextRun SCXW77106795 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW77106795 BCX8"> test data</span> <span class="NormalTextRun SCXW77106795 BCX8">to assess genotoxic risk. </span></span></p> </div> </div> <div class="elementor-element elementor-element-c910e34 elementor-widget elementor-widget-text-editor" data-id="c910e34" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span class="TextRun SCXW255978078 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW255978078 BCX8">Retrieve standardised and curated toxicological data</span></span><span class="EOP SCXW255978078 BCX8" data-ccp-props="{}"> </span></strong><br /><span class="TextRun SCXW238558630 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW238558630 BCX8">Sarah Nexus utilises a machine-learned, self-organising hypothesis network (SOHN) </span><span class="NormalTextRun SCXW238558630 BCX8">methodology</span><span class="NormalTextRun SCXW238558630 BCX8">, where </span><span class="NormalTextRun SCXW238558630 BCX8">chemical structures </span><span class="NormalTextRun SCXW238558630 BCX8">are</span><span class="NormalTextRun SCXW238558630 BCX8"> standardised and curated</span><span class="NormalTextRun SCXW238558630 BCX8"> to</span> <span class="NormalTextRun SCXW238558630 BCX8">generate </span><span class="NormalTextRun SCXW238558630 BCX8">accurate</span><span class="NormalTextRun SCXW238558630 BCX8"> Ames results for each data point.</span> <span class="NormalTextRun SCXW238558630 BCX8">This approach results </span><span class="NormalTextRun CommentHighlightPipeRestV2 SCXW238558630 BCX8">in a SOHN model </span><span class="NormalTextRun SCXW238558630 BCX8">containing</span> <span class="NormalTextRun SCXW238558630 BCX8">hundreds of</span><span class="NormalTextRun SCXW238558630 BCX8"> unique hypotheses, offering powerful predictive insights.</span></span></p> </div> </div> <div class="elementor-element elementor-element-394241e elementor-widget elementor-widget-text-editor" data-id="394241e" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;"><b>Early risk identification</b></span></strong><br /><span style="font-weight: 400;"><span class="TextRun SCXW220236130 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW220236130 BCX8">Predict the genotoxic potential of compounds early in the </span><span class="NormalTextRun SCXW220236130 BCX8">chemical</span><span class="NormalTextRun SCXW220236130 BCX8"> development process, allowing for the identification and elimination of high-risk candidates before costly and time-consuming </span></span><em><span class="TextRun SCXW220236130 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW220236130 BCX8">in vitro</span></span></em><span class="TextRun SCXW220236130 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW220236130 BCX8"> or </span></span><em><span class="TextRun SCXW220236130 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW220236130 BCX8">in vivo</span></span></em><span class="TextRun SCXW220236130 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW220236130 BCX8"> testing.</span></span></span></p> </div> </div> <div class="elementor-element elementor-element-38ead55 elementor-align-left elementor-widget elementor-widget-button" data-id="38ead55" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="/contact-us"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Get in touch</span> </span> </a> </div> </div> </div> <div class="elementor-element elementor-element-49bd7f4c elementor-widget elementor-widget-menu-anchor" data-id="49bd7f4c" data-element_type="widget" data-widget_type="menu-anchor.default"> <div class="elementor-widget-container"> <div class="elementor-menu-anchor" id="Sarah"></div> </div> </div> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-e67d491" data-id="e67d491" data-element_type="column" data-settings="{"background_background":"gradient"}"> <div class="elementor-widget-wrap"> </div> </div> </div> </section> <section data-dce-background-color="#FFFFFF" class="elementor-section elementor-top-section elementor-element elementor-element-d448ef6 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="d448ef6" data-element_type="section" data-settings="{"jet_parallax_layout_list":[],"background_background":"classic"}"> <div class="elementor-background-overlay"></div> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-7af6e1a" data-id="7af6e1a" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-a7a8021" data-id="a7a8021" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-21ce919 dce_masking-none elementor-widget elementor-widget-image" data-id="21ce919" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img loading="lazy" decoding="async" width="2382" height="810" src="https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO.png" class="attachment-full size-full wp-image-1556" alt="DEREK LOGO" srcset="https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO.png 2382w, https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO-300x102.png 300w, https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO-1024x348.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO-768x261.png 768w, https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO-1536x522.png 1536w, https://www.lhasalimited.org/wp-content/uploads/2022/11/DEREK_LOGO-2048x696.png 2048w" sizes="(max-width: 2382px) 100vw, 2382px"> </div> </div> <div class="elementor-element elementor-element-da78c1f elementor-widget elementor-widget-text-editor" data-id="da78c1f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>Derek Nexus</strong> <span class="TextRun SCXW122963738 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW122963738 BCX8">is an expert, knowledge-based prediction software that can help you to </span><span class="NormalTextRun SCXW122963738 BCX8">establish</span><span class="NormalTextRun SCXW122963738 BCX8"> if there is a toxicity hazard associated with your compound.</span></span><span class="EOP SCXW122963738 BCX8" data-ccp-props="{}"> </span></p> </div> </div> </div> </div> <div data-dce-background-overlay-color="#FFFFFF" class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-e33d911" data-id="e33d911" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-background-overlay"></div> <div class="elementor-element elementor-element-c9d7154 elementor-widget elementor-widget-heading" data-id="c9d7154" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Derek Nexus highlights</h2> </div> </div> <div class="elementor-element elementor-element-b58385b elementor-widget elementor-widget-text-editor" data-id="b58385b" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span class="TextRun SCXW147450657 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun CommentStart SCXW147450657 BCX8">Access expert structure-activity relationship (SAR) knowledge for many</span><span class="NormalTextRun SCXW147450657 BCX8"> genotoxicity endpoints</span></span></strong><span class="LineBreakBlob BlobObject DragDrop SCXW147450657 BCX8"><span class="SCXW147450657 BCX8"> </span><br class="SCXW147450657 BCX8" /></span><span class="TextRun SCXW147450657 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW147450657 BCX8">Derek Nexus </span><span class="NormalTextRun SCXW147450657 BCX8">contains</span><span class="NormalTextRun SCXW147450657 BCX8"> SAR knowledge for </span><span class="NormalTextRun SCXW147450657 BCX8">multiple genotoxicity</span> <span class="NormalTextRun SCXW147450657 BCX8">endpoints</span><span class="NormalTextRun SCXW147450657 BCX8">,</span><span class="NormalTextRun SCXW147450657 BCX8"> including</span><span class="NormalTextRun SCXW147450657 BCX8"> mutagenicity, chromosome damage, photo mutagenicity</span><span class="NormalTextRun SCXW147450657 BCX8"> and </span><span class="NormalTextRun SCXW147450657 BCX8">photo chromosome </span><span class="NormalTextRun SCXW147450657 BCX8">damage</span><span class="NormalTextRun SCXW147450657 BCX8">,</span><span class="NormalTextRun SCXW147450657 BCX8"> covering both</span></span><em><span class="TextRun SCXW147450657 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW147450657 BCX8"> in vitro</span></span></em><span class="TextRun SCXW147450657 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW147450657 BCX8"> and</span></span><em><span class="TextRun SCXW147450657 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW147450657 BCX8"> in vivo</span></span></em><span class="TextRun SCXW147450657 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW147450657 BCX8"> predictions.</span><span class="NormalTextRun SCXW147450657 BCX8"> The SAR knowledge is derived from both public and proprietary member data sources and is updated as new data becomes available.</span></span><span class="EOP SCXW147450657 BCX8" data-ccp-props="{}"> </span></p> </div> </div> <div class="elementor-element elementor-element-358d3b27 elementor-widget elementor-widget-text-editor" data-id="358d3b27" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span class="TextRun SCXW194086227 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW194086227 BCX8">Identify</span> <span class="NormalTextRun SpellingErrorV2Themed SCXW194086227 BCX8">toxicophores</span><span class="NormalTextRun SCXW194086227 BCX8">,</span><span class="NormalTextRun SCXW194086227 BCX8"> highlighting possible hazard</span></span><span class="TrackChangeTextInsertion TrackedChange SCXW194086227 BCX8"><span class="TextRun SCXW194086227 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW194086227 BCX8">s</span></span></span></strong><span class="LineBreakBlob BlobObject DragDrop SCXW194086227 BCX8"><strong><span class="SCXW194086227 BCX8"> </span></strong><br class="SCXW194086227 BCX8" /></span><span class="TextRun SCXW194086227 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW194086227 BCX8">The expert comments associated with a Derek Nexus alert can help you to decide if this compound structure is a concern or not.</span> <span class="NormalTextRun SCXW194086227 BCX8">Each prediction comes with </span><span class="NormalTextRun CommentStart CommentHighlightPipeRestV2 CommentHighlightRest SCXW194086227 BCX8">a clear, scientifically grounded explanation, outlining the</span><span class="NormalTextRun CommentHighlightPipeRestV2 SCXW194086227 BCX8"> reasoning behind the outcome. </span></span><span class="EOP SCXW194086227 BCX8" data-ccp-props="{}"> </span></p> </div> </div> <div class="elementor-element elementor-element-1a089b5c elementor-widget elementor-widget-text-editor" data-id="1a089b5c" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span class="TextRun SCXW79422970 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW79422970 BCX8">Understand the SAR behind predictions </span></span></strong><span class="LineBreakBlob BlobObject DragDrop SCXW79422970 BCX8"><strong><span class="SCXW79422970 BCX8"> </span></strong><br class="SCXW79422970 BCX8" /></span><span class="TextRun SCXW79422970 BCX8" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW79422970 BCX8">The scientific comments which </span><span class="NormalTextRun SCXW79422970 BCX8">accompany</span><span class="NormalTextRun SCXW79422970 BCX8"> a Derek Nexus alert will describe the chemical and biological mechanisms of action where possible.</span> <span class="NormalTextRun SCXW79422970 BCX8">This transparency aids in regulatory submission, providing the rationale required to support expert review and decision-making.</span></span><span class="EOP SCXW79422970 BCX8" data-ccp-props="{}"> </span></p> </div> </div> <div class="elementor-element elementor-element-5c5b35a elementor-align-left elementor-widget elementor-widget-button" data-id="5c5b35a" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button 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With Vitic, you can easily determine if relevant data already exists for your compound.</p> </div> </div> </div> </div> <div class="elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-8800808" data-id="8800808" data-element_type="column" data-settings="{"background_background":"classic"}"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-945b3e4 elementor-widget elementor-widget-heading" data-id="945b3e4" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Vitic highlights</h2> </div> </div> <div class="elementor-element elementor-element-7218e21 elementor-widget elementor-widget-text-editor" data-id="7218e21" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><span style="color: #333f48;"><b>Explore hundreds of<em> in vivo</em> and <em>in vitro</em> genetic toxicology study records</b></span></strong><br /><span class="NormalTextRun SCXW112111960 BCX8">Vitic</span> <span class="NormalTextRun SCXW112111960 BCX8">contains</span><span class="NormalTextRun SCXW112111960 BCX8"> a wealth of high-quality</span><span class="NormalTextRun SCXW112111960 BCX8"> carcinogenicity and genotoxicity</span><span class="NormalTextRun SCXW112111960 BCX8"> data to support chemical risk assessments. </span><span class="NormalTextRun SCXW112111960 BCX8">This broader scope allows for a more complete assessment of your impurities, helping you evaluate their safety with confidence.</span></p> </div> </div> <div class="elementor-element elementor-element-d41f6af elementor-widget elementor-widget-text-editor" data-id="d41f6af" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span style="color: #333f48;"><span class="TextRun SCXW76754443 BCX8" lang="EN-GB" 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d="M203.94,120.63c15.7,0,31.4-.09,47.1,.04,9.09,.07,14.94,8.53,11.51,16.49-2.17,5.03-6.25,7.42-11.7,7.42-13.04,.01-26.08,0-39.12,0-18.36,0-36.72,.06-55.08-.03-9.39-.04-15.41-8.4-11.91-16.5,2.25-5.2,6.49-7.45,12.1-7.44,15.7,.04,31.4,.01,47.1,.01Z"></path><path class="cls-5" d="M300.27,333.02c7.91-8.36,14.75-15.78,21.8-23,5.94-6.09,11.98-12.1,18.19-17.9,7.21-6.74,17.75-3.92,20.24,5.25,1.19,4.38,0,8.28-3.11,11.37-16.24,16.1-32.5,32.19-48.93,48.09-4.94,4.79-11.44,4.66-16.53-.09-8.36-7.8-16.57-15.76-24.65-23.85-4.97-4.98-4.97-12.01-.42-16.85,4.5-4.79,11.53-5.04,16.85-.43,2.81,2.43,5.47,5.06,8.04,7.75,2.57,2.69,4.94,5.58,8.53,9.67Z"></path></svg> </div> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-cada9e4" data-id="cada9e4" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-789f769 elementor-widget elementor-widget-heading" data-id="789f769" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">ICH M7</h2> </div> </div> <div class="elementor-element elementor-element-2bdb0b3 elementor-widget elementor-widget-text-editor" data-id="2bdb0b3" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>The <a href="https://www.ema.europa.eu/en/ich-m7-assessment-control-dna-reactive-mutagenic-impurities-pharmaceuticals-limit-potential" target="_blank" rel="noopener">ICH M7 guideline</a> states that “Two (Q)SAR prediction methodologies that complement each other should be applied. One methodology should be expert rule-based & the second should be statistical-based”. Combining a Derek Nexus expert rule-based prediction and a Sarah Nexus statistical prediction can provide a full ICH M7 classification.</p> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-95cbb28 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="95cbb28" data-element_type="section" data-settings="{"jet_parallax_layout_list":[]}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-d2f4d77" data-id="d2f4d77" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-751a1c6 elementor-view-default elementor-widget elementor-widget-icon" data-id="751a1c6" data-element_type="widget" data-widget_type="icon.default"> <div class="elementor-widget-container"> <div 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d="M203.94,120.63c15.7,0,31.4-.09,47.1,.04,9.09,.07,14.94,8.53,11.51,16.49-2.17,5.03-6.25,7.42-11.7,7.42-13.04,.01-26.08,0-39.12,0-18.36,0-36.72,.06-55.08-.03-9.39-.04-15.41-8.4-11.91-16.5,2.25-5.2,6.49-7.45,12.1-7.44,15.7,.04,31.4,.01,47.1,.01Z"></path><path class="cls-5" d="M300.27,333.02c7.91-8.36,14.75-15.78,21.8-23,5.94-6.09,11.98-12.1,18.19-17.9,7.21-6.74,17.75-3.92,20.24,5.25,1.19,4.38,0,8.28-3.11,11.37-16.24,16.1-32.5,32.19-48.93,48.09-4.94,4.79-11.44,4.66-16.53-.09-8.36-7.8-16.57-15.76-24.65-23.85-4.97-4.98-4.97-12.01-.42-16.85,4.5-4.79,11.53-5.04,16.85-.43,2.81,2.43,5.47,5.06,8.04,7.75,2.57,2.69,4.94,5.58,8.53,9.67Z"></path></svg> </div> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-6adc159" data-id="6adc159" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-1fac920 elementor-widget elementor-widget-heading" data-id="1fac920" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Guidance on the establishment of the residue definition for dietary risk assessment</h2> </div> </div> <div class="elementor-element elementor-element-d094bf4 elementor-widget elementor-widget-text-editor" data-id="d094bf4" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>The aim of the <a href="https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2016.4549" target="_blank" rel="noopener">EFSA guidance</a> is to guide the complex process of identifying the pertinent residue components that should be considered for dietary risk assessments of chemical active substances. Our (Q)SAR tools, Derek Nexus and Sarah Nexus, can be used for metabolite hazard identification and characterisation of these compounds.</p> </div> </div> <div class="elementor-element elementor-element-1d65b3a elementor-align-center elementor-widget elementor-widget-button" data-id="1d65b3a" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="/contact-us"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Get in touch</span> </span> </a> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-5c0faa4 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="5c0faa4" data-element_type="section" data-settings="{"jet_parallax_layout_list":[],"background_background":"classic"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fcc26d6" data-id="fcc26d6" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-788f595 elementor-widget elementor-widget-heading" data-id="788f595" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Related publications</h2> </div> </div> <div class="elementor-element elementor-element-b129eec premium-cursor-icon premium-gbadge-stripe premium-gbadge-row premium-gbadge-right premium-gbadge-top elementor-widget elementor-widget-jet-listing-grid" data-id="b129eec" data-element_type="widget" data-settings="{"columns":"1"}" 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elementor-section-height-default elementor-section-height-default" data-id="7a09055" data-element_type="section" data-settings="{"jet_parallax_layout_list":[],"background_background":"classic"}"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a0c81fc" data-id="a0c81fc" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-4421db8 elementor-widget elementor-widget-heading" data-id="4421db8" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Recent blogs</h2> </div> </div> <div class="elementor-element elementor-element-1b2e7fc premium-blog-align-left elementor-widget elementor-widget-global elementor-global-7984 elementor-widget-premium-addon-blog" data-id="1b2e7fc" 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href="https://www.lhasalimited.org/blog/lhasa-interviews-2023-richard-williams-award-winner/" target="_self"> Lhasa speaks with the 2023 Richard Williams Award Winner </a> </h2> </div> <div class="premium-blog-content-inner-wrapper"> <p class="premium-blog-post-content">The Richard Williams Memorial Award, established in 2020, honours the scientific contributions and memory of Dr. Richard Williams. This award recognises exceptional …</p> </div> <div class="premium-blog-entry-meta"> </div> </div> </div> </div> <div class="premium-blog-post-outer-container" data-total="27"> <div class="premium-blog-post-container premium-blog-skin-cards"> <div class="premium-blog-thumb-effect-wrapper"> <div class="premium-blog-thumbnail-container premium-blog-none-effect"> <a href="https://www.lhasalimited.org/blog/10-faqs-about-mirabilis-pharmaceutical-impurity-control-using-in-silico-tools/" target="_self"> <img loading="lazy" decoding="async" width="1080" height="864" src="https://www.lhasalimited.org/wp-content/uploads/2024/10/blog-images.png" class="attachment-full size-full wp-image-11461" alt="blog images" srcset="https://www.lhasalimited.org/wp-content/uploads/2024/10/blog-images.png 1080w, https://www.lhasalimited.org/wp-content/uploads/2024/10/blog-images-300x240.png 300w, https://www.lhasalimited.org/wp-content/uploads/2024/10/blog-images-1024x819.png 1024w, https://www.lhasalimited.org/wp-content/uploads/2024/10/blog-images-768x614.png 768w" sizes="(max-width: 1080px) 100vw, 1080px" /> </a> </div> <div class="premium-blog-effect-container premium-blog-none-effect"> <a class="premium-blog-post-link" href="https://www.lhasalimited.org/blog/10-faqs-about-mirabilis-pharmaceutical-impurity-control-using-in-silico-tools/" target="_self"><span>10 FAQs About Mirabilis: Pharmaceutical Impurity Control Using In Silico Tools</span></a> </div> </div> <div class="premium-blog-content-wrapper "> <div class="premium-blog-inner-container"> <h2 class="premium-blog-entry-title"> <a href="https://www.lhasalimited.org/blog/10-faqs-about-mirabilis-pharmaceutical-impurity-control-using-in-silico-tools/" target="_self"> 10 FAQs About Mirabilis: Pharmaceutical Impurity Control Using In Silico Tools </a> </h2> </div> <div class="premium-blog-content-inner-wrapper"> <p class="premium-blog-post-content">Identification and control of impurities in active pharmaceutical ingredients (APIs) and pharmaceutical drug products is critical in drug development. Mirabilis is our …</p> </div> <div class="premium-blog-entry-meta"> </div> </div> </div> </div> <div class="premium-blog-post-outer-container" data-total="27"> <div class="premium-blog-post-container premium-blog-skin-cards"> <div class="premium-blog-thumb-effect-wrapper"> <div class="premium-blog-thumbnail-container premium-blog-none-effect"> <a href="https://www.lhasalimited.org/blog/eurotox-2024-advancing-toxicology-in-copenhagen/" target="_self"> <img loading="lazy" decoding="async" width="1080" height="864" src="https://www.lhasalimited.org/wp-content/uploads/2024/09/Eurotox-blog.jpg" class="attachment-full size-full wp-image-11241" alt="EUROTOX 2024: A memorable gathering in Copenhagen" srcset="https://www.lhasalimited.org/wp-content/uploads/2024/09/Eurotox-blog.jpg 1080w, https://www.lhasalimited.org/wp-content/uploads/2024/09/Eurotox-blog-300x240.jpg 300w, https://www.lhasalimited.org/wp-content/uploads/2024/09/Eurotox-blog-1024x819.jpg 1024w, https://www.lhasalimited.org/wp-content/uploads/2024/09/Eurotox-blog-768x614.jpg 768w" sizes="(max-width: 1080px) 100vw, 1080px" /> </a> </div> <div class="premium-blog-effect-container premium-blog-none-effect"> <a class="premium-blog-post-link" href="https://www.lhasalimited.org/blog/eurotox-2024-advancing-toxicology-in-copenhagen/" target="_self"><span>EUROTOX 2024: Advancing toxicology in Copenhagen</span></a> </div> </div> <div class="premium-blog-content-wrapper "> <div class="premium-blog-inner-container"> <h2 class="premium-blog-entry-title"> <a href="https://www.lhasalimited.org/blog/eurotox-2024-advancing-toxicology-in-copenhagen/" target="_self"> EUROTOX 2024: Advancing toxicology in Copenhagen </a> </h2> </div> <div class="premium-blog-content-inner-wrapper"> <p class="premium-blog-post-content">We had a fantastic time at EUROTOX 2024, held from 8 – 11th September in the picturesque city of Copenhagen, Denmark. 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selected='selected'>True</option></select></div></div><div id="field_8_20" class="gfield gfield--type-select gfield--input-type-select gfield--width-full field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_hidden" data-js-reload="field_8_20" ><div class='admin-hidden-markup'><i class='gform-icon gform-icon--hidden'></i><span>Hidden</span></div><label class='gfield_label gform-field-label' for='input_8_20'>Surveys</label><div class='ginput_container ginput_container_select'><select name='input_20' id='input_8_20' class='large gfield_select' aria-invalid="false" ><option value='True' selected='selected'>True</option></select></div></div><div id="field_8_19" class="gfield gfield--type-select gfield--input-type-select gfield--width-full field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_hidden" data-js-reload="field_8_19" ><div class='admin-hidden-markup'><i class='gform-icon 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