急性肝性ポルフィリン症（AHP）の急性発作の主な誘因

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block-porphyriajp-top-level-title-block"> <div class="top-level-title-block"> <div class="top-level-title-block__inner"> <h1 class="top-level-title-block__title">症状</h1> </div> </div> </div> <div id="block-link-to-supervisor-page" class="block block-fixed-block-content block-fixed-block-contentlink-to-supervisor-page"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p class="link-to-supervisor-page"><span class="link-to-supervisor-page__label">監修:</span><a href="/supervision">堀江裕先生<span class="link-to-supervisor-page__position">（島根県済生会江津総合病院名誉院長、芝浦スリーワンクリニック・ポルフィリン症外来）</span></a></p> </div> </div> <div id="block-porphyriajp-content" class="block block-system block-system-main-block"> <article role="article" about="/symptom/triggers-for-acute-attacks" typeof="schema:WebPage" class="node node--type-page node--view-mode-full"> <span property="schema:name" content="急性発作の主な誘因" class="rdf-meta hidden"></span> <div class="node__content"> <div property="schema:text" class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><h1>急性発作の主な誘因</h1> <p>急性肝性ポルフィリン症（acute hepatic porphyria：AHP）の急性発作の誘因としては、フェノバルビタールなどのある種の薬物、生理前や妊娠、出産など性ホルモンのアンバランス、タバコ、アルコール、感染症、カロリー摂取不足、ストレスなどが知られています<sup>1</sup>。 <span class="br">AHPの予防・治療・予後においては、アルコールやストレスなど排除可能な環境要因をできるだけ避けること、また、カロリー摂取が不足しないよう生活習慣を整えることも重要です。</span></p> <div class="image-box"> <figure class="scalable-figure"> <figcaption class="scalable-figure__caption">急性肝性ポルフィリン症の発症・増悪の誘因</figcaption> <div class="js-scalable-container"> <div class="js-scalable-content scalable-content"> <table class="basic-table basic-table--with-summary-column triggers-table"> <caption class="basic-table__note"><span>AIP: 急性間欠性ポルフィリン症、</span><span>VP: 異型ポルフィリン症、</span><span>HCP: 遺伝性コプロポルフィリン症、</span><span>PCT: 晩発性皮膚型ポルフィリン症</span></caption> <thead> <tr> <th> </th> <th>AIP<br /> (198例中)</th> <th>VP<br /> (56例中)</th> <th>HCP<br /> (41例中)</th> <th>分類不明<br /> (58例中)</th> <th>PCT<br /> (328例中)</th> <th>計<br /> (681例中)</th> </tr> </thead> <tbody> <tr> <th>フェノバルビタール</th> <td>24</td> <td>7</td> <td>12</td> <td>3</td> <td>1</td> <td>47</td> </tr> <tr> <th>解熱、鎮痛、鎮痙剤</th> <td>26</td> <td>1</td> <td>1</td> <td>2</td> <td>3</td> <td>33</td> </tr> <tr> <th>妊娠、月経、分娩</th> <td>33</td> <td>2</td> <td>2</td> <td>2</td> <td>1</td> <td>40</td> </tr> <tr> <th>ピル</th> <td>6</td> <td>1</td> <td>1</td> <td>0</td> <td>0</td> <td>8</td> </tr> <tr> <th>眠剤</th> <td>3</td> <td>1</td> <td>0</td> <td>0</td> <td>0</td> <td>4</td> </tr> <tr> <th>アルコール</th> <td>4</td> <td>1</td> <td>0</td> <td>1</td> <td>253</td> <td>259</td> </tr> <tr> <th>血液透析</th> <td>0</td> <td>0</td> <td>0</td> <td>3</td> <td>9</td> <td>12</td> </tr> <tr> <th>その他</th> <td>10</td> <td>1</td> <td>2</td> <td>0</td> <td>14</td> <td>27</td> </tr> <tr> <th>小計</th> <td>106</td> <td>14</td> <td>18</td> <td>11</td> <td>281</td> <td>430</td> </tr> <tr> <th>不明</th> <td>92</td> <td>42</td> <td>23</td> <td>47</td> <td>47</td> <td>251</td> </tr> </tbody> </table> </div> </div> </figure> </div> <dl class="references"> <dt class="references__label">参考文献</dt> <dd class="references__content"> <ol class="references__list"> <li class="references__item"><span>近藤雅雄, 矢野雄三, 浦田郡平. <i>ALA-Porphyrin Science</i>. 2012;1(2):73-82.</span></li> </ol> </dd> </dl> <ul class="node-pc-pager"> <li class="node-pc-pager__item node-pc-pager__item--prev"><a href="/symptom/importance-of-differential-diagnosis"><span class="node-pc-pager__title">AHPにおける鑑別診断の重要性</span></a></li> <li class="node-pc-pager__item node-pc-pager__item--next"><a href="/symptom/complication-risk"><span class="node-pc-pager__title">長期罹患に伴う合併症リスク</span></a></li> </ul> <ol class="node-sp-pager"> <li class="node-sp-pager__item"><a href="/symptom/AHP-symptoms">AHPの症状</a></li> <li class="node-sp-pager__item"><a href="/symptom/importance-of-differential-diagnosis">AHPにおける鑑別診断の重要性</a></li> <li class="node-sp-pager__item is-active"><span>急性発作の主な誘因</span></li> <li class="node-sp-pager__item"><a href="/symptom/complication-risk">長期罹患に伴う合併症リスク</a></li> </ol> </div> </div> </article> </div> </div> </div> </main> <div class="layout-modal"> <div class="region region-modal"> <div id="block-modal-confirm" class="block block-fixed-block-content block-fixed-block-contentmodal-confirm"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="modal-confirm js-modal-confirm"> <div class="modal-confirm__inner"> <p class="modal-confirm__body">このサイトの情報は日本国内の医療関係者を対象とするもので、一般の方および国外の医療関係者に対する情報提供を目的としたものではありません。<br /> あなたは日本国内の医療関係者ですか？</p> <div class="modal-confirm__actions"><button class="modal-confirm__button js-ok-button" type="button">はい</button><a class="modal-confirm__button" href="https://www.alnylam.jp/">いいえ</a></div> </div> </div> </div> </div> <div id="block-waibusaitohenoqianyiquerenmotaru" class="block 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急性肝性ポルフィリン症（AHP）の急性発作の主な誘因 | Porphyria.jp