Cancer | Bio-Techne

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You can browse below or search in the search bar above.</p> <h2><br> Table of Contents</h2> <ul> <li><a href="#Cancer Disease Types">Cancer Disease Types </a></li> <li><a href="#Cancer Research Areas">Cancer Research Areas</a></li> <li><a href="#Cancer Targets">Cancer Targets</a> </li> <li><a href="#Products and Services">Products and Services</a></li> <li><a href="#cancer resources">Cancer Resources & Tools</a></li> <li><a href="#Background and FAQs">Background and FAQs</a></li> </ul></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/53BP1-antibody-immunohistochemistry-paraffin-nb100-304-img0013-v2.jpg" alt="Detection of Human and Mouse 53BP1 by IHC in ovarian cancer cells image" > </div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_image_caption"> <div>FFPE sections of human ovarian carcinoma (left) & mouse teratoma:<br>53BP1 Antibody (#NB100-304)</div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="Cancer Disease Types"></a>Cancer Disease Types </h2> <p>Browse research products by Cancer disease Type</p> <figure class="responsive-figure-table"><table class="table table-striped"> <tbody> <tr> <td class="w-25"><a href="/search?search_type=products&keywords=breast+cancer">Breast Cancer</a></td> <td><a href="/search?search_type=products&keywords=leukemia">Leukemia</a></td> <td class="w-25"><a href="/research-areas/lung-cancer">Lung Cancer</a></td> <td><a href="/search?search_type=products&keywords=prostate+cancer">Prostate Cancer</a></td> </tr> <tr> <td><a href="https://www.tocris.com/research-area/colorectal-cancer" target="_blank">Colorectal Cancer</a> (at tocris.com)</td> <td><a 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mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="Cancer Targets"></a>Cancer Targets</h2> <p>Browse research products by cancer targets:</p> <h4>Featured Cancer Targets</h4> <figure class="responsive-figure-table"><table class="table table-striped"> <tbody> <tr> <td class="w-25"><a href="/search?search_type=products&keywords=γ-secretase+">γ-secretase </a></td> <td class="w-25"><a href="/search?search_type=products&keywords=EGFR">EGFR</a></td> <td class="w-25"><a href="/search?search_type=products&keywords=Histone+Deacetylases">Histone Deacetylases (HDACs)</a></td> <td><a href="/search?search_type=products&keywords=Matrix+Metalloprotease">Matrix Metalloprotease</a></td> </tr> <tr> <td><a href="/search?search_type=products&keywords=MAPK">MAPKs</a></td> <td><a href="/search?search_type=products&keywords=p53">p53</a></td> <td><a href="/search?search_type=products&keywords=PI+3-Kinases">PI 3-Kinases</a></td> <td><a 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href="/resources/signal-transduction-pathways/mapk-erk-pathway">MAPK/ERK Pathway</a></li> <li><a href="/resources/signal-transduction-pathways/p38-mapk">p38 MAPK Pathway</a></li> <li><a href="/resources/signal-transduction-pathways/jnk-signaling-pathway">JNK Pathway</a></li> <li><a href="/resources/signal-transduction-pathways/akt-signaling-pathway">AKT Pathway</a></li> <li><a href="/resources/signal-transduction-pathways/apoptosis-pathway">Apoptosis Pathway</a></li> <li><a href="/resources/signal-transduction-pathways/autophagy-pathway">Autophagy Pathway</a></li> </ul> <ul> </ul></div> <div class="col-4 column-group"><h3> </h3> <h3>View All <a href="/resources/scientific-articles?tid_3%5B186%5D=186">Cancer Articles</a> <a href="/resources/blogs">& Blogs</a></h3> <ul> <li><a href="/resources/scientific-articles/erk-signal-transduction-pathway">The ERK Signal Transduction Pathway: Its Role in Growth Factor Signaling and Cancer</a></li> <li><a href="/resources/scientific-articles/a-simple-flow-cytometry-based-assay-for-car-detection-using-fluorokines">A Simple Flow Cytometry-Based Assay for CAR Detection Using Fluorokines™</a></li> <li><a href="https://www.bio-techne.com/resources/blogs/tired-t-cells-hypoxia-drives-t-cell-exhaustion-in-the-tumor-microenvironment" rel="bookmark">Tired T cells: Hypoxia Drives T cell Exhaustion in the Tumor Microenvironment</a></li> <li><a href="https://www.bio-techne.com/resources/blogs/harnessing-natural-killer-cell-activity-for-anti-tumor-immunotherapy" rel="bookmark">Harnessing Natural Killer Cell Activity for Anti-Tumor Immunotherapy</a></li> </ul></div> <div class="col-4 column-group"><h3> </h3> <h3>View All <a href="/resources/protocols-troubleshooting?tid_4%5B186%5D=186">Cancer Protocols</a></h3> <ul> <li><a href="/resources/protocols-troubleshooting/human-lung-organoid-culture">Human Lung Organoid Culture Protocol</a></li> <li><a href="/resources/protocols-troubleshooting/cellular-response-hypoxia">Cellular Response to Hypoxia Protocols</a></li> <li><a href="/resources/protocols-troubleshooting/immunocytochemistry">Immunocytochemistry (ICC) Protocol</a></li> <li><a href="/resources/protocols-troubleshooting/apoptosis-flow-annexin-v-protocol">Annexin V and PI Staining for Apoptosis by Flow Cytometry</a></li> <li><a href="https://www.bio-techne.com/resources/protocols-troubleshooting/western-blot" rel="bookmark">Western Blot Protocol</a></li> </ul> <p> </p></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="Background and FAQs"></a>Cancer Background and FAQs</h2> <p><a href="#Tumor Suppressors">Tumor Suppressors</a> |<a href="#Oncogenes"> Oncogenes</a> | <a name="References">References & Further Reading</a></p> <p>Cancer encompasses a wide range of diseases where cellular proliferation goes unchecked leading to increased cell growth and decreased cell death. Genetic alterations, which may be inherited or result from environmental influence, represent the main basic underlying mechanism for disease onset and progression. Accelerated growth, programmed cell death evasion, immune checkpoint evasion and ability to invade distant tissues are all hallmark properties of cancerous cells. These abnormal cellular properties are brought about by mutations in genes involved in the regulation of cell proliferation and growth, including proto-oncogenes and tumor suppressor genes. Additionally, mutations in genes involved in DNA repair further undermine the integrity of DNA sequences facilitating the accumulation of multiple DNA lesions in cancer cells.</p> <p>Traditionally, cancer types have been identified based on the site of origin and afflicted organ or tissue. In the US, prostate and breast cancer represent the most prevalent cancer types afflicting males and females, respectively. It is also noteworthy that lung cancer causes ~25% of cancer-related deaths in both males and females. Lung cancer causes more deaths annually than breast, prostate, and colon cancer combined.</p> <p> </p> <p><strong><a name="Tumor Suppressors"></a>What are Tumor </strong><strong>Suppressors</strong><strong>?</strong></p> <p>Tumor suppressors are genes that protect cells from cancerous transformations. But, occasionally, these genes mutate and a loss in function leads to cancer. This is in contrast to oncogenes, which cause cancer through a mutation resulting in a gain of function. Tumor suppressor genes are often grouped into three categories: Caretakers, gatekeepers, and landscapers. Gatekeepers are those genes which prevent abnormal cell proliferation, caretakers provide genomic stability (through assessing and correcting DNA damage/mismatches/chromosomal abnormalities), and landscapers control the microenvironment in which cells grow.</p> <p><a href="/t/p53">p53</a> is often referred to as the “master” tumor suppressor gene because it is involved in the broadest of cancers. It can act as caretaker or gatekeeper and plays a role in <a href="/research-areas/apoptosis">apoptosis</a>, genomic stability, and <a href="/research-areas/cancer/angiogenesis">angiogenesis</a> inhibition. There have been hundreds of other tumor suppressors reported and there continues to be new targets discovered through the field of oncogenomics. Bio-Techne has an extensive catalog of <a href="/search?keywords=tumor+suppressor&category_attr=Primary%20Antibodies">tumor suppressor antibodies</a> to suit most researchers needs.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><strong><a name="Oncogenes"></a>What are Oncogenes?</strong></p> <p>Oncogenes are genes that are critical to the cause and proliferation of cancer. Normal, non-mutated forms of these genes (proto-oncogenes) code for proteins that regulate cell growth and differentiation. In contrast to tumor suppressors, they are involved in cancer through a gain of function, not loss of function (caused by a mutation, increased expression, or chromosome rearrangement). Many current cancer therapies focus on targeting proteins that are encoded by oncogenes.</p> <p>There are many known and proposed mechanisms of oncogenesis, which can lead to abnormal cell growth. Some well-studied drivers of malignancy include mutation of proteins involved in intracellular signaling (such as <a href="/t/mapk">MAPK</a>/<a href="/t/erk">ERK</a> and <a href="/t/pi3k">PI3K</a>/<a href="/t/akt">AKT</a>/<a href="/t/mtor">MTOR</a> pathways), mutation of growth factor receptors (ex. <a href="/t/pdgf">PDGF</a>), and excess expression of growth factors (ex. <a href="/t/erbb2">ErbB2/HER2</a>).</p></div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/p/antibodies/c-myc-antibody-9e11_nb200-108" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/nb-c-myc-antibody-525x350.png" alt="Novus Biologicals C-Myc Antibody Graph" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/p/antibodies/c-myc-antibody-9e11_nb200-108" > <h3 class="card_title_htag"></h3> </a> <div class="card_description flex-grow-1"> </div> <div class="card-bottom-link"> <div> <a href="/p/antibodies/c-myc-antibody-9e11_nb200-108" > c-Myc Antibody (9E11) NB200-108 </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/p/antibodies/53bp1-antibody_nb100-304" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/53bp1-antibody-immunohistochemistry-paraffin-nb100-304-img0017.jpg" alt="Immunohistochemical Analysis of 53BP1 in Paraffin Embedded Breast Tumors" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/p/antibodies/53bp1-antibody_nb100-304" > <h3 class="card_title_htag"></h3> </a> <div class="card_description flex-grow-1"> </div> <div class="card-bottom-link"> <div> <a href="/p/antibodies/53bp1-antibody_nb100-304" > 53BP1 Antibody - BSA Free </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/p/antibodies/human-mouse-rat-ras-gap-antibody_af5094" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/ras-gap-af5094-western-blot-5627.jpg" alt="Human/Mouse/Rat Ras-GAP Antibody gel image" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/p/antibodies/human-mouse-rat-ras-gap-antibody_af5094" > <h3 class="card_title_htag"></h3> </a> <div class="card_description flex-grow-1"> </div> <div class="card-bottom-link"> <div> <a href="/p/antibodies/human-mouse-rat-ras-gap-antibody_af5094" > Human/Mouse/Rat Ras-GAP Antibody </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="References"></a></p></div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-selected-references-amp-further-reading7" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Selected References & Further Reading</h5> </a> </div> <div class="collapse" id="expPara-selected-references-amp-further-reading7" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p><strong>Select References for further reading</strong><br> <br> Aoki, K., & Taketo, M. M. (2007). <a href="https://www.ncbi.nlm.nih.gov/pubmed/17881494">Adenomatous polyposis coli (APC): a multi-functional </a><a href="https://www.ncbi.nlm.nih.gov/pubmed/17881494">tumor</a><a href="https://www.ncbi.nlm.nih.gov/pubmed/17881494"> suppressor gene</a>. Journal of Cell Science. <a href="https://doi.org/10.1242/jcs.03485">https://doi.org/10.1242/jcs.03485</a></p> <p>Fuhrman-Luck, R. A., Loessner, D., & Clements, J. A. (2014). <a href="https://www.semanticscholar.org/paper/Kallikrein-Related-Peptidases-in-Prostate-Cancer%3A-Fuhrman-Luck-Loessner/7c082cd2457dff7aad4aeeafd0043fe83562b37c">Kallikrein-Related Peptidases in Prostate Cancer: From Molecular Function to Clinical Application</a>. EJIFCC. PMCID: PMC4975200</p> <p>Goldar, S., Khaniani, M. S., Derakhshan, S. M., & Baradaran, B. (2015). <a href="https://pdfs.semanticscholar.org/52a1/0aebd517be62fe6cbca80664d1a4f18f0dde.pdf">Molecular mechanisms of apoptosis and roles in cancer development and treatment.</a> Asian Pacific Journal of Cancer Prevention. <a href="https://doi.org/10.7314/APJCP.2015.16.6.2129">https://doi.org/10.7314/APJCP.2015.16.6.2129</a></p> <p>Hassanpour, S. H., & Dehghani, M. (2017). <a href="https://www.researchgate.net/publication/318347992_Review_of_cancer_from_perspective_of_molecular">Review of cancer from perspective of molecular</a>. Journal of Cancer Research and Practice. <a href="https://doi.org/10.1016/j.jcrpr.2017.07.001">https://doi.org/10.1016/j.jcrpr.2017.07.001</a></p> <p>Jaiswal, P. K., Goel, A., & Mittal, R. D. (2015). <a href="https://www.researchgate.net/publication/279302299_Survivin_A_molecular_biomarker_in_cancer">Survivin</a><a href="https://www.researchgate.net/publication/279302299_Survivin_A_molecular_biomarker_in_cancer">: A molecular biomarker in cancer</a>. Indian Journal of Medical Research. <a href="https://doi.org/10.1002/stem.592">https://doi.org/10.1002/stem.592</a></p> <p>Maguer-Satta, V., Besançon, R., & Bachelard-Cascales, E. (2011). <a href="https://www.ncbi.nlm.nih.gov/pubmed/21425402">Concise review: Neutral endopeptidase (CD10): A multifaceted environment actor in stem cells, physiological mechanisms, and cancer</a>. Stem Cells. <a href="https://doi.org/10.1002/stem.592">https://doi.org/10.1002/stem.592</a></p> <p>Sau, A., Lau, R., Cabrita, M. A., Nolan, E., Crooks, P. A., Visvader, J. E., & Pratt, M. A. C. (2016). <a href="https://www.ncbi.nlm.nih.gov/pubmed/27292187">Persistent Activation of NF-</a><a href="https://www.ncbi.nlm.nih.gov/pubmed/27292187">κ</a><a href="https://www.ncbi.nlm.nih.gov/pubmed/27292187">B in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage</a>. Cell Stem Cell. <a href="https://doi.org/10.1016/j.stem.2016.05.003">https://doi.org/10.1016/j.stem.2016.05.003</a></p> <p>Yang, D., Wu, Z., Duan, H., Luo, Y., Lu, D., Li, W., … Yan, X. (2011). <a href="https://www.researchgate.net/publication/51973434_CD146_an_epithelial-mesenchymal_transition_inducer_is_associated_with_triple-negative_breast_cancer">CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer</a>. Proceedings of the National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1111053108">https://doi.org/10.1073/pnas.1111053108</a></p> <p>Zamay, T. N., Zamay, G. S., Kolovskaya, O. S., Zukov, R. A., Petrova, M. M., Gargaun, A., … Kichkailo, A. S. (2017). <a href="https://www.researchgate.net/publication/321045814_Current_and_Prospective_Protein_Biomarkers_of_Lung_Cancer">Current and prospective protein biomarkers of lung cancer</a>. Cancers. <a href="https://doi.org/10.3390/cancers9110155">https://doi.org/10.3390/cancers9110155</a></p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article> </div> </div> </section> </main> </div> <div id="brandsbar-footer" class="bg-bt-primary"> <div class="container-wide container-fluid text-white"> <div class="row py-5"> <div class="footer-logo col-xl-3 col-lg-auto d-flex"> <img class="brand-bar-footer-logo" src="/themes/custom/bio_techne_global/logo.svg" alt="Bio-techne logo"> </div> <div class="col-xl-9 col-lg-auto"> <p class="ml-xl-4 bt-px_groteskbold footer-tagline">Global Developer, Manufacturer, and Supplier of High-Quality Reagents, Analytical Instruments, and Precision Diagnostics.</p> </div> <div class="included-brands col"> <span class="font-weight-bold mr-3 bt-inter_regular">INCLUDES</span> <span class="mr-3 bt-inter_regular">R&D Systems™</span> <span class="mr-3 bt-inter_regular">Novus Biologicals™</span> <span class="mr-3 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