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class="right__hamburger"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#fff" stroke-linecap="round" stroke-width="1.5" d="M3 4.25h14m-14 6h14m-14 6h14"/></svg></button> </div> </div> </div> </header> <main class="DefaultTemplate"> <section class="HeadingButtonsImage HeadingButtonsImage--image"> <div class="row"> <div class="HeadingButtonsImage__content"> <h1 class="content__title">Leading Hypoxia Research</h1> <div class="content__description"><p>Our laboratory focuses on oxygen transport, O2 measurement, hypoxia tolerance, & high-altitude physiology.</p> </div> <div class="content__row"> <a class="Button Button__type--2" title="Study Capabilities" href="https://hypoxialab.com/sponsored-research/" > <span class="Button__label">Study Capabilities</span> <span class="Loader"><span class="Loader__animation"></span></span> </a> <a class="Button Button__type--1" title="Become a Participant" href="https://hypoxialab.com/study-participation/" > <span 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</section> <section class="ContentWithGrid"> <div class="row"> <div class="ContentWithGrid__content"> <h2 class="content__heading">Areas of Research</h2> <div class="content__description"><p>A major focus of the laboratory is the evaluation of pulse oximeter performance, especially as relates to accuracy in people of all genders, sizes, and skin colors.聽 We partner with the <a href="https://globalsurgery.org/" target="_blank" rel="noopener">UCSF Center for Health Equity in Surgery & Anesthesia</a> to reduce health disparities by improving access to safe pulse oximeters worldwide. We are an independent university-based testing facility with non-profit status through UCSF.</p> </div> </div> <div class="ContentWithGrid__grid"> <div class="grid__item"> <div class="image-wrapper image-wrapper--svg item__icon"> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-1-was56o.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-1-was56o.svg" sizes="100vw"> </picture> </div> </div> <div class="item__label"> <p class="label__content">Human Adaptation to High Altitude</p> </div> </div> <div class="grid__item"> <div class="image-wrapper image-wrapper--svg item__icon"> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-2-ok5n1k.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-2-ok5n1k.svg" sizes="100vw"> </picture> </div> </div> <div class="item__label"> <p class="label__content">Controlled Desaturation Studies</p> </div> </div> <div class="grid__item"> <div class="image-wrapper image-wrapper--svg item__icon"> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-3-vbo040.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-3-vbo040.svg" sizes="100vw"> </picture> </div> </div> <div class="item__label"> <p class="label__content">Oximetry Device Testing & Development</p> </div> </div> <div class="grid__item"> <div class="image-wrapper image-wrapper--svg item__icon"> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-4-jvtsio.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-4-jvtsio.svg" sizes="100vw"> </picture> </div> </div> <div class="item__label"> <p class="label__content">Clinical Trials</p> </div> </div> <div class="grid__item"> <div class="image-wrapper image-wrapper--svg item__icon"> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-5-ux35uc.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-5-ux35uc.svg" sizes="100vw"> </picture> </div> </div> <div class="item__label"> <p class="label__content">Regulatory Science</p> </div> </div> <div class="grid__item"> <div class="image-wrapper image-wrapper--svg item__icon"> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-6-52lgpx.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/08/17/research-6-52lgpx.svg" sizes="100vw"> </picture> </div> </div> <div class="item__label"> <p class="label__content">Medical Devices for Public Health Crises</p> </div> </div> </div> </div> </section> <section class="ServicesCarousel ServicesCarousel__type--white" data-jsmodule="ServicesCarousel"> <div class="ServicesCarousel__header"> <div class="row"> <div class="header__content"> <h2 class="content__heading">Our Services</h2> </div> </div> </div> <div class="ServicesCarousel__carousel"> <div class="carousel__item" data-index="0"> <div class="item__content"> <div class="content__thumbnail"> <div class="image-wrapper image-wrapper--svg "> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/12/01/standard-pulse-ox-study-rra0rb.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/12/01/standard-pulse-ox-study-rra0rb.svg" sizes="100vw"> </picture> </div> </div> </div> <h3 class="content__heading">Standard Pulse Oximeter Study</h3> <div class="content__description"><p>We determine the accuracy of pulse oximeters by exposing volunteers to short periods of low oxygen levels (75-100% SaO2) while monitoring how the oximeter responds. This helps us understand if these devices are accurate for everyone regardless of skin color during these low oxygen conditions.</p> </div> <a class="content__link Button Button__type--3" href="https://hypoxialab.com/service/sample-research/" title="Standard Pulse Oximeter Study" > <span class="Button__label">Read more</span> <span class="Loader"><span class="Loader__animation"></span></span> <span class="Button__icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#006BE9" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg> </span> </a> </div> </div> <div class="carousel__item" data-index="1"> <div class="item__content"> <div class="content__thumbnail"> <div class="image-wrapper image-wrapper--svg "> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/12/01/motion-testing-zrzoac.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/12/01/motion-testing-zrzoac.svg" sizes="100vw"> </picture> </div> </div> </div> <h3 class="content__heading">Motion Testing</h3> <div class="content__description"><p>During pulse oximetry testing, we can include tools that mimic patient movements. These tools, which come from the manufacturer, are called motion fixtures. They help us simulate scenarios where a patient might be moving, allowing us to see how well the pulse oximeters perform in situations with motion during low oxygen conditions.</p> </div> <a class="content__link Button Button__type--3" href="https://hypoxialab.com/service/motion-testing/" title="Motion Testing" > <span class="Button__label">Read more</span> <span class="Loader"><span class="Loader__animation"></span></span> <span class="Button__icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#006BE9" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg> </span> </a> </div> </div> <div class="carousel__item" data-index="2"> <div class="item__content"> <div class="content__thumbnail"> <div class="image-wrapper image-wrapper--svg "> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/12/01/methemoglobin-study-dior8q.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/12/01/methemoglobin-study-dior8q.svg" sizes="100vw"> </picture> </div> </div> </div> <h3 class="content__heading">Methemoglobin Study</h3> <div class="content__description"><p>We assess pulse oximeters tailored for detecting methemoglobin (metHb), a hemoglobin type not carrying oxygen as usual. To ensure if pulse oximeters reliably detect elevated metHb levels during low-oxygen conditions, volunteers undergo brief low-oxygen exposure (75-100% SaO2) while we observe oximeter responses.</p> </div> <a class="content__link Button Button__type--3" href="https://hypoxialab.com/service/methemoglobin/" title="Methemoglobin Study" > <span class="Button__label">Read more</span> <span class="Loader"><span class="Loader__animation"></span></span> <span class="Button__icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#006BE9" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg> </span> </a> </div> </div> <div class="carousel__item" data-index="3"> <div class="item__content"> <div class="content__thumbnail"> <div class="image-wrapper image-wrapper--svg "> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/12/01/carboxyhemoglobin-study-mx0pmc.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/12/01/carboxyhemoglobin-study-mx0pmc.svg" sizes="100vw"> </picture> </div> </div> </div> <h3 class="content__heading">Carboxyhemoglobin Study</h3> <div class="content__description"><p>We assess pulse oximeters tailored for detecting carboxyhemoglobin (COHb), a hemoglobin type not carrying oxygen as usual. To ensure if pulse oximeters reliably detect elevated COHb levels during low-oxygen conditions, volunteers undergo brief low-oxygen exposure (75-100% SaO2) while we observe oximeter responses.</p> </div> <a class="content__link Button Button__type--3" href="https://hypoxialab.com/service/carbon-monoxide/" title="Carboxyhemoglobin Study" > <span class="Button__label">Read more</span> <span class="Loader"><span class="Loader__animation"></span></span> <span class="Button__icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#006BE9" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg> </span> </a> </div> </div> <div class="carousel__item" data-index="4"> <div class="item__content"> <div class="content__thumbnail"> <div class="image-wrapper image-wrapper--svg "> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/12/01/cerebral-ox-study-zuho67.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/12/01/cerebral-ox-study-zuho67.svg" sizes="100vw"> </picture> </div> </div> </div> <h3 class="content__heading">Cerebral Oximetry Study</h3> <div class="content__description"><p>We’re studying cerebral oximeters to gauge their accuracy in measuring brain oxygen levels. Comparing readings with direct blood measurements from the artery (SaO2) and jugular vein (SjvO2) helps us assess performance, particularly when arterial oxyhemoglobin saturation (SaO2) is between 70% and 100%.</p> </div> <a class="content__link Button Button__type--3" href="https://hypoxialab.com/service/iso-510k-pulse-oximetry-testing/" title="Cerebral Oximetry Study" > <span class="Button__label">Read more</span> <span class="Loader"><span class="Loader__animation"></span></span> <span class="Button__icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#006BE9" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg> </span> </a> </div> </div> <div class="carousel__item" data-index="5"> <div class="item__content"> <div class="content__thumbnail"> <div class="image-wrapper image-wrapper--svg "> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/12/01/low-perfusion-testing-cai4dr.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/12/01/low-perfusion-testing-cai4dr.svg" sizes="100vw"> </picture> </div> </div> </div> <h3 class="content__heading">Low Perfusion Testing</h3> <div class="content__description"><p>With low perfusion testing, we can simulate low perfusion (reduced blood flow) using clamps or cuffs. We can also test in various body positions, like the Trendelenburg position. This allows us to examine how well devices perform under low oxygen conditions (75-100% SaO2) where blood flow may be limited or changed.</p> </div> <a class="content__link Button Button__type--3" href="https://hypoxialab.com/service/low-perfusion-testing/" title="Low Perfusion Testing" > <span class="Button__label">Read more</span> <span class="Loader"><span class="Loader__animation"></span></span> <span class="Button__icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#006BE9" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg> </span> </a> </div> </div> <div class="carousel__item" data-index="6"> <div class="item__content"> <div class="content__thumbnail"> <div class="image-wrapper image-wrapper--svg "> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/12/01/transcutaneous-carbon-dioxide-sensor-testing-znnxyg.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/12/01/transcutaneous-carbon-dioxide-sensor-testing-znnxyg.svg" sizes="100vw"> </picture> </div> </div> </div> <h3 class="content__heading">Transcutaneous Carbon Dioxide Sensor Testing</h3> <div class="content__description"><p>We’re testing transcutaneous carbon dioxide sensors to see how well they monitor carbon dioxide levels in the blood. We’re examining their performance alone and when used with pulse oximetry and desaturation of oxyhemoglobin (a component of the blood that carries oxygen).</p> </div> <a class="content__link Button Button__type--3" href="https://hypoxialab.com/service/transcutaneous-carbon-dioxide-sensor-testing/" title="Transcutaneous Carbon Dioxide Sensor Testing" > <span class="Button__label">Read more</span> <span class="Loader"><span class="Loader__animation"></span></span> <span class="Button__icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#006BE9" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg> </span> </a> </div> </div> <div class="carousel__item" data-index="7"> <div class="item__content"> <div class="content__thumbnail"> <div class="image-wrapper image-wrapper--svg "> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/12/01/drug-induced-apnea-testing-h7ppu0.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/12/01/drug-induced-apnea-testing-h7ppu0.svg" sizes="100vw"> </picture> </div> </div> </div> <h3 class="content__heading">Drug-Induced Apnea Testing</h3> <div class="content__description"><p>Using medications like Propofol and Remifentanil, we induce temporary breathing pauses (apneic events) to simulate opioid-related respiratory slowdown. The aim is to evaluate how effectively the oximeter combination can identify this reduced oxygen condition, crucial for monitoring patients in these specific medical situations.</p> </div> <a class="content__link Button Button__type--3" href="https://hypoxialab.com/service/drug-induced-apnea-testing-study/" title="Drug-Induced Apnea Testing" > <span class="Button__label">Read more</span> <span class="Loader"><span class="Loader__animation"></span></span> <span class="Button__icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#006BE9" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg> </span> </a> </div> </div> <div class="carousel__item" data-index="8"> <div class="item__content"> <div class="content__thumbnail"> <div class="image-wrapper image-wrapper--svg "> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/12/01/neonatal-accuracy-testing-zseitw.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/12/01/neonatal-accuracy-testing-zseitw.svg" sizes="100vw"> </picture> </div> </div> </div> <h3 class="content__heading">Neonatal Accuracy Testing</h3> <div class="content__description"><p>To ensure pulse oximeters work effectively in diverse scenarios, we test them on neonates undergoing heart surgery, where physiological conditions change. Multiple blood samples are taken, providing insights into oximeter performance amidst rapidly changing variables.</p> </div> <a class="content__link Button Button__type--3" href="https://hypoxialab.com/service/neonatal-accuracy-testing/" title="Neonatal Accuracy Testing" > <span class="Button__label">Read more</span> <span class="Loader"><span class="Loader__animation"></span></span> <span class="Button__icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#006BE9" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg> </span> </a> </div> </div> <div class="carousel__item" data-index="9"> <div class="item__content"> <div class="content__thumbnail"> <div class="image-wrapper image-wrapper--svg "> <div class="asset"> <picture class="lazy-load-item" data-iesrc="https://hypoxialab.com/wp-content/uploads/2023/12/04/profound-hemodilution-study-dsgopa.svg" > <source srcset="https://hypoxialab.com/wp-content/uploads/2023/12/04/profound-hemodilution-study-dsgopa.svg" sizes="100vw"> </picture> </div> </div> </div> <h3 class="content__heading">Profound Hemodilution Study</h3> <div class="content__description"><p>This study aims to assess the accuracy of new non-invasive pulse oximeters, measuring total blood hemoglobin without skin puncture. By temporarily removing and re-infusing blood in healthy volunteers (isovolemic hemodilution), we induce changes in hemoglobin concentration.</p> </div> <a class="content__link Button Button__type--3" href="https://hypoxialab.com/service/profound-hemodilution-study/" title="Profound Hemodilution Study" > <span class="Button__label">Read more</span> <span class="Loader"><span class="Loader__animation"></span></span> <span class="Button__icon"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#006BE9" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg> </span> </a> </div> </div> </div> <div class="ServicesCarousel__control"> <button aria-label="Scroll left" class="control__button control__button--prev" disabled><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m13 16-6-6 6-6"/></svg></button> <button aria-label="Scroll right" class="control__button control__button--next"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 20 20"><path stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.5" d="m7 4 6 6-6 6"/></svg></button> </div> </section> </main> <footer class="Footer"> <div class="row"> <div class="Footer__row"> <div class="row__home"> <a href="https://hypoxialab.com" title="Homepage" class="home__link"> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/logo-white.svg" width="160" height="24" alt="logo-white" class="svg"/> </a> </div> <ul id="nav_footer_left" class="row__nav row__nav--left"> <li class="nav__item"> <a href="https://hypoxialab.com/about-us/" title="About Us" >About Us</a> </li> <li class="nav__item"> <a href="https://hypoxialab.com/sponsored-research/" title="Sponsored Research" >Sponsored Research</a> </li> <li class="nav__item"> <a href="https://hypoxialab.com/study-participation/" title="Study Participation" >Study Participation</a> </li> <li class="nav__item"> <a href="https://hypoxialab.com/publications/" title="Research" >Research</a> </li> </ul> <ul id="nav_footer_right" class="row__nav row__nav--right"> <li class="nav__item"> <a href="https://hypoxialab.com/privacy-policy/" title="Privacy Policy" >Privacy Policy</a> </li> <li class="nav__item"> <a href="https://hypoxialab.com/terms-of-use/" title="Terms of Use" >Terms of Use</a> </li> </ul> </div> <div class="Footer__links"> <a href="https://goo.gl/maps/59jbdpePh9CHr8aq5" title="Go to Google Map" target="_blank" class="links__single"> <img src="https://hypoxialab.com/wp-content/themes/hypoxia-lab/assets/svg/icon-location.svg" width="20" height="20" alt="icon-location" class="svg"/> <span>400 Parnassus Ave; 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