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Dipòsit Digital de la Universitat de Barcelona: Association of APOA5 and APOC3 genetic polymorphisms with severity of hypertriglyceridemia in patients with cutaneous T-Cell lymphoma treated with bexarotene
<!DOCTYPE html> <html> <head> <title>Dipòsit Digital de la Universitat de Barcelona: Association of APOA5 and APOC3 genetic polymorphisms with severity of hypertriglyceridemia in patients with cutaneous T-Cell lymphoma treated with bexarotene</title> <base href="https://diposit.ub.edu" /> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <meta name="Generator" content="DSpace 5.8" /> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link rel="shortcut icon" href="/dspace/favicon.ico" type="image/x-icon"/> <link rel="stylesheet" href="/dspace/static/css/jquery-ui-1.10.3.custom/redmond/jquery-ui-1.10.3.custom.css" type="text/css" /> <link rel="stylesheet" href="/dspace/static/css/bootstrap/bootstrap.min.css" type="text/css" /> <link rel="stylesheet" href="/dspace/static/css/bootstrap/bootstrap-theme.min.css" type="text/css" /> <link rel="stylesheet" href="/dspace/static/css/bootstrap/dspace-theme.css" type="text/css" /> <link rel="search" type="application/opensearchdescription+xml" href="/dspace/open-search/description.xml" title="DSpace"/> <link rel="schema.DCTERMS" href="http://purl.org/dc/terms/" /> <link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" /> <meta name="DC.creator" content="Cabello Zamora, Irene" /> <meta name="DC.creator" content="Alia, Pedro" /> <meta name="DC.creator" content="Pintó Sala, Xavier" /> <meta name="DC.creator" content="Muniesa Montserrat, Cristina" /> <meta name="DC.creator" content="Fernández de Misa, Ricardo" /> <meta name="DC.creator" content="Peñate, Yerai" /> <meta name="DC.creator" content="Morillo, Mercedes" /> <meta name="DC.creator" content="Pérez-Ferriols, Amparo" /> <meta name="DC.creator" content="Estrach Panella, Ma. Teresa (María Teresa)" /> <meta name="DC.creator" content="Izu, Rosa" /> <meta name="DC.creator" content="Gallardo, F. (Fernando)" /> <meta name="DC.creator" content="Román, Concepción" /> <meta name="DC.creator" content="Cervigón, Iván" /> <meta name="DC.creator" content="Ortiz Brugués, Ariadna" /> <meta name="DC.creator" content="Ortiz Romero, Pablo Luis" /> <meta name="DC.creator" content="Servitje Bedate, Octavio" /> <meta name="DCTERMS.dateAccepted" content="2019-01-22T12:27:46Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.available" content="2019-12-01T06:10:13Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.issued" content="2018-12-01" scheme="DCTERMS.W3CDTF" /> <meta name="DC.identifier" content="2168-6068" /> <meta name="DC.identifier" content="https://hdl.handle.net/2445/127512" scheme="DCTERMS.URI" /> <meta name="DCTERMS.abstract" content="Importance: hypertriglyceridemia is the most frequent and limiting adverse effect of bexarotene therapy in cutaneous T-cell lymphoma (CTCL). Despite standard prophylactic measures, there is a wide variability in the severity of this complication, which could be associated with both genetic and environmental factors. Objectives: to analyze the association between genetic polymorphisms of apolipoprotein genes APOA5, APOC3, and APOE and the severity of hypertriglyceridemia during bexarotene therapy and to optimize patient selection for bexarotene therapy based on adverse effect profile. Design, Setting, and Participants: this case series study was conducted in 12 university referral hospitals in Spain from September 17, 2014, to February 6, 2015. One hundred twenty-five patients with a confirmed diagnosis of CTCL who had received bexarotene therapy for at least 3 months were enrolled. Nine patients were excluded owing to missing analytic triglyceride level data, leaving a study group of 116 patients. Data on demographic and cardiovascular risk factor were collected, and a complete blood analysis, including lipid profile and genetic analysis from a saliva sample, was performed. Main Outcomes and Measures: primary outcomes were the maximal triglyceride levels reported in association with the minor alleles of the polymorphisms studied. Results: among 116 patients, the mean (SD) age was 61.2 (14.7) years, 69 (59.5%) were men, and 85 (73.2%) had mycosis fungoides, the most prevalent form of CTCL. During bexarotene therapy, 96 patients (82.7%) experienced hypertriglyceridemia, which was severe or extreme in 8 of these patients (8.3%). Patients who carried minor alleles of the polymorphisms did not show significant differences in baseline triglyceride concentrations. After bexarotene treatment, carriers of at least 1 of the 2 minor alleles of APOA5 c.-1131T>C and APOC3 c.*40C>G showed lower levels of triglycerides than noncarriers (mean [SD], 241.59 [169.91] vs 330.97 [169.03] mg/dL, respectively; P = .02). Conclusions and Relevance: these results indicate that the screening of APOA5 and APOC3 genotypes may be useful to estimate changes in triglyceride concentrations during bexarotene treatment in patients with CTCL and also to identify the best candidates for bexarotene therapy based on the expected adverse effect profile." /> <meta name="DCTERMS.extent" content="8 p." /> <meta name="DC.format" content="application/pdf" /> <meta name="DC.language" content="eng" scheme="DCTERMS.RFC1766" /> <meta name="DC.publisher" content="American Medical Association" /> <meta name="DCTERMS.isFormatOf" content="Reproducció del document publicat a: https://doi.org/10.1001/jamadermatol.2018.3679" /> <meta name="DCTERMS.isPartOf" content="JAMA Dermatology, 2018, vol. 154, num. 12, p. 1424-1431" /> <meta name="DC.relation" content="https://doi.org/10.1001/jamadermatol.2018.3679" scheme="DCTERMS.URI" /> <meta name="DC.rights" content="(c) American Medical Association, 2018" /> <meta name="DC.source" content="Articles publicats en revistes (Ciències Clíniques)" /> <meta name="DC.subject" content="Polimorfisme genètic" /> <meta name="DC.subject" content="Triglicèrids" /> <meta name="DC.subject" content="Efectes secundaris dels medicaments" /> <meta name="DC.subject" content="Medicaments antineoplàstics" /> <meta name="DC.subject" content="Càncer de pell" /> <meta name="DC.subject" content="Genetic polymorphisms" /> <meta name="DC.subject" content="Triglycerides" /> <meta name="DC.subject" content="Drug side effects" /> <meta name="DC.subject" content="Antineoplastic agents" /> <meta name="DC.subject" content="Skin cancer" /> <meta name="DC.title" content="Association of APOA5 and APOC3 genetic polymorphisms with severity of hypertriglyceridemia in patients with cutaneous T-Cell lymphoma treated with bexarotene" /> <meta name="DC.type" content="info:eu-repo/semantics/article" /> <meta name="DC.type" content="info:eu-repo/semantics/publishedVersion" /> <meta name="DC.identifier" content="682972" /> <meta name="DC.date" content="2019-01-22T12:27:46Z" scheme="DCTERMS.W3CDTF" /> <meta name="DC.rights" content="info:eu-repo/semantics/openAccess" /> <meta name="DC.identifier" content="30422238" /> <meta name="citation_keywords" content="info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion" /> <meta name="citation_title" content="Association of APOA5 and APOC3 genetic polymorphisms with severity of hypertriglyceridemia in patients with cutaneous T-Cell lymphoma treated with bexarotene" /> <meta name="citation_issn" content="2168-6068" /> <meta name="citation_publisher" content="American Medical Association" /> <meta name="citation_language" content="eng" /> <meta name="citation_author" content="Cabello Zamora, Irene" /> <meta name="citation_author" content="Alia, Pedro" /> <meta name="citation_author" content="Pintó Sala, Xavier" /> <meta name="citation_author" content="Muniesa Montserrat, Cristina" /> <meta name="citation_author" content="Fernández de Misa, Ricardo" /> <meta name="citation_author" content="Peñate, Yerai" /> <meta name="citation_author" content="Morillo, Mercedes" /> <meta name="citation_author" content="Pérez-Ferriols, Amparo" /> <meta name="citation_author" content="Estrach Panella, Ma. Teresa (María Teresa)" /> <meta name="citation_author" content="Izu, Rosa" /> <meta name="citation_author" content="Gallardo, F. (Fernando)" /> <meta name="citation_author" content="Román, Concepción" /> <meta name="citation_author" content="Cervigón, Iván" /> <meta name="citation_author" content="Ortiz Brugués, Ariadna" /> <meta name="citation_author" content="Ortiz Romero, Pablo Luis" /> <meta name="citation_author" content="Servitje Bedate, Octavio" /> <meta name="citation_pdf_url" content="https://diposit.ub.edu/dspace/bitstream/2445/127512/3/682972.pdf" /> <meta name="citation_date" content="2018-12-01" /> <meta name="citation_abstract_html_url" content="https://diposit.ub.edu/dspace/handle/2445/127512" /> <script type='text/javascript' src="/dspace/static/js/jquery/jquery-1.10.2.min.js"></script> <script type='text/javascript' src='/dspace/static/js/jquery/jquery-ui-1.10.3.custom.min.js'></script> <script type='text/javascript' src='/dspace/static/js/bootstrap/bootstrap.min.js'></script> <script type='text/javascript' src='/dspace/static/js/holder.js'></script> <script type="text/javascript" src="/dspace/utils.js"></script> <script type="text/javascript" src="/dspace/static/js/choice-support.js"> </script> <!-- /* <script type="text/javascript"> var _gaq = _gaq || []; _gaq.push(['_setAccount', 'UA-9816681-2']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 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Teresa (María Teresa)</a><br /><a class="author"href="/dspace/browse?type=author&value=Izu%2C+Rosa">Izu, Rosa</a><br /><a class="author"href="/dspace/browse?type=author&value=Gallardo%2C+F.+%28Fernando%29">Gallardo, F. (Fernando)</a><br /><a class="author"href="/dspace/browse?type=author&value=Rom%C3%A1n%2C+Concepci%C3%B3n">Román, Concepción</a><br /><a class="author"href="/dspace/browse?type=author&value=Cervig%C3%B3n%2C+Iv%C3%A1n">Cervigón, Iván</a><br /><a class="author"href="/dspace/browse?type=author&value=Ortiz+Brugu%C3%A9s%2C+Ariadna">Ortiz Brugués, Ariadna</a><br /><a class="author"href="/dspace/browse?type=author&value=Ortiz+Romero%2C+Pablo+Luis">Ortiz Romero, Pablo Luis</a><br /><a class="author"href="/dspace/browse?type=author&value=Servitje+Bedate%2C+Octavio">Servitje Bedate, Octavio</a></td></tr> <tr><td class="metadataFieldLabel">Keywords: </td><td class="metadataFieldValue">Polimorfisme genètic<br />Triglicèrids<br />Efectes secundaris dels medicaments<br />Medicaments antineoplàstics<br />Càncer de pell<br />Genetic polymorphisms<br />Triglycerides<br />Drug side effects<br />Antineoplastic agents<br />Skin cancer</td></tr> <tr><td class="metadataFieldLabel">Issue Date: </td><td class="metadataFieldValue">1-Dec-2018</td></tr> <tr><td class="metadataFieldLabel">Publisher: </td><td class="metadataFieldValue">American Medical Association</td></tr> <tr><td class="metadataFieldLabel">Abstract: </td><td class="metadataFieldValue">Importance: hypertriglyceridemia is the most frequent and limiting adverse effect of bexarotene therapy in cutaneous T-cell lymphoma (CTCL). Despite standard prophylactic measures, there is a wide variability in the severity of this complication, which could be associated with both genetic and environmental factors. Objectives: to analyze the association between genetic polymorphisms of apolipoprotein genes APOA5, APOC3, and APOE and the severity of hypertriglyceridemia during bexarotene therapy and to optimize patient selection for bexarotene therapy based on adverse effect profile. Design, Setting, and Participants: this case series study was conducted in 12 university referral hospitals in Spain from September 17, 2014, to February 6, 2015. One hundred twenty-five patients with a confirmed diagnosis of CTCL who had received bexarotene therapy for at least 3 months were enrolled. Nine patients were excluded owing to missing analytic triglyceride level data, leaving a study group of 116 patients. Data on demographic and cardiovascular risk factor were collected, and a complete blood analysis, including lipid profile and genetic analysis from a saliva sample, was performed. Main Outcomes and Measures: primary outcomes were the maximal triglyceride levels reported in association with the minor alleles of the polymorphisms studied. Results: among 116 patients, the mean (SD) age was 61.2 (14.7) years, 69 (59.5%) were men, and 85 (73.2%) had mycosis fungoides, the most prevalent form of CTCL. During bexarotene therapy, 96 patients (82.7%) experienced hypertriglyceridemia, which was severe or extreme in 8 of these patients (8.3%). Patients who carried minor alleles of the polymorphisms did not show significant differences in baseline triglyceride concentrations. After bexarotene treatment, carriers of at least 1 of the 2 minor alleles of APOA5 c.-1131T>C and APOC3 c.*40C>G showed lower levels of triglycerides than noncarriers (mean [SD], 241.59 [169.91] vs 330.97 [169.03] mg/dL, respectively; P = .02). Conclusions and Relevance: these results indicate that the screening of APOA5 and APOC3 genotypes may be useful to estimate changes in triglyceride concentrations during bexarotene treatment in patients with CTCL and also to identify the best candidates for bexarotene therapy based on the expected adverse effect profile.</td></tr> <tr><td class="metadataFieldLabel">Note: </td><td class="metadataFieldValue">Reproducció del document publicat a: https://doi.org/10.1001/jamadermatol.2018.3679</td></tr> <tr><td class="metadataFieldLabel">It is part of: </td><td class="metadataFieldValue">JAMA Dermatology, 2018, vol. 154, num. 12, p. 1424-1431</td></tr> <tr><td class="metadataFieldLabel">URI: </td><td class="metadataFieldValue"><a href="https://hdl.handle.net/2445/127512">https://hdl.handle.net/2445/127512</a></td></tr> <tr><td class="metadataFieldLabel">Related resource: </td><td class="metadataFieldValue"><a href="https://doi.org/10.1001/jamadermatol.2018.3679">https://doi.org/10.1001/jamadermatol.2018.3679</a></td></tr> <tr><td class="metadataFieldLabel">ISSN: </td><td class="metadataFieldValue">2168-6068</td></tr> <tr><td class="metadataFieldLabel">Appears in Collections:</td><td class="metadataFieldValue"><a href="/dspace/handle/2445/107206">Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)</a><br/><a href="/dspace/handle/2445/7983">Articles publicats en revistes (Ciències Clíniques)</a><br/><a href="/dspace/handle/2445/7204">Articles publicats en revistes (Medicina)</a><br/><a href="/dspace/handle/2445/67491">Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))</a><br/></td></tr> </table><br/> <div class="panel panel-info"><div class="panel-heading">Files in This Item:</div> <table class="table panel-body"><tr><th id="t1" class="standard">File</th> <th id="t2" class="standard">Description</th> <th id="t3" class="standard">Size</th><th id="t4" class="standard">Format</th><th> </th></tr> <tr><td headers="t1" class="standard"><a target="_blank" href="/dspace/bitstream/2445/127512/3/682972.pdf">682972.pdf</a></td><td headers="t2" class="standard"></td><td headers="t3" class="standard">150.85 kB</td><td headers="t4" class="standard">Adobe PDF</td><td class="standard" align="center"><a class="btn btn-primary" target="_blank" href="/dspace/bitstream/2445/127512/3/682972.pdf">View/Open</a></td></tr></table> </div> <div class="container row"> <a class="btn btn-default" href="/dspace/handle/2445/127512?mode=full"> Show full item record </a> </div> <br/> <br/> <p class="submitFormHelp alert alert-info"> Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated. <!-- a href=""><img src="/dspace/image/cc-somerights.gif" border="0" alt="Creative Commons" style="margin-top: -5px;" class="pull-right"/></a --> <!-- %= cc_rdf % --> </p> <div class="addthis_sharing_toolbox"></div> </div> </main> <footer class="navbar navbar-inverse navbar-bottom" style='background:-webkit-linear-gradient(#6685a9,#406086);background:-o-linear-gradient(#6685a9,#406086);background:-moz-linear-gradient(#6685a9,#406086);background:linear-gradient(#6685a9,#406086);border-radius:0;border:0;width:100%'> <div id="designedby" class="container text-muted"> <!-- fmt:message key="jsp.layout.footer-default.theme-by"/> <a href="http://www.cineca.it"><img src="/dspace/image/logo-cineca-small.png" alt="Logo CINECA" /></a --> <div id="footer_feedback" class="pull-left"> <p class="text-muted"> <span style='color:white'>Coordination: </span> <a style='color:#000' onMouseOver="this.style.color='#fff'" onMouseOut="this.style.color='#000'" target='_blank' href='http://crai.ub.edu/en'> CRAI Universitat de Barcelona</a> <a style='color:#000' onMouseOver="this.style.color='#fff'" onMouseOut="this.style.color='#000'" target="_blank" href='http://www.ub.edu/web/ub/en/menu_peu/avislegal/avis_legal.html'>Legal notice</a> </p> </div> <div id="footer_feedback" class="pull-right"> <p class="text-muted"> <span style='color:white'>Metadata subject to: </span> <a target='_blank' href='http://creativecommons.org/publicdomain/zero/1.0/'> <img src="/dspace/image/logoCC.png" alt="Logo CC" /> </a> <span style='color:white'>Powered by: </span> <a style='color:#000' onMouseOver="this.style.color='#fff'" onMouseOut="this.style.color='#000'" target="_blank" href="http://dspace.org/">DSpace</a> <a style='color:#000' onMouseOver="this.style.color='#fff'" onMouseOut="this.style.color='#000'" target="_blank" href="/dspace/feedback">Contact us</a> </p> </div> <!-- div id="footer_feedback" class="pull-right"> <p class="text-muted"><a target="_blank" href="http://www.dspace.org/">DSpace Software</a> Copyright © 2002-2013 <a target="_blank" href="http://www.duraspace.org/">Duraspace</a> - <a target="_blank" href="/dspace/feedback">Contact us</a> <a href="/dspace/htmlmap"></a></p> </div --> </div> </footer> </body> </html>