Immunoassays for Immune Response Profiling

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class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:h1_2_2_text_to_media:field_indv_h1"> <div><h1>Immunoassays for Immune Response Profiling</h1></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:h1_2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/DW-Immune-Cell-Therapy-Treg-Cell-Foreground-v2-STRY0112373.png" alt="Treg Cell Image" fetchpriority="high" > </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> </header> </div> <div id="main" class="container-fluid container-wide"> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/applications">Applications</a> </li> <li> <a href="/applications/immunoassays">Immunoassay Workflow Solutions</a> </li> <li> Immunoassays For Immune Response Profiling </li> </ol> </nav> </div> </div> </div> </div> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Quality is at the Core of Our Immune Response Profiling Immunoassays</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/ibu-scientist-lab-lifestyle-525x380.jpg" alt="Multiplex immunoassays for biomarker research" loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Quality at the core means you can depend on our immunoassays for consistent, high-quality immune response profiling data over the long term.</p> <ul> <li><strong>Vertical Integration:</strong> Immunoassays are built with in-house antibodies and diluents, thus guaranteeing a long-term supply of consistent and reliable immunoassays.</li> <li><strong>Rigorous Quality Assurance and Quality Control Processes:</strong> Our immunoassays uphold the highest standards of consistency, linearity, recovery, and specificity</li> <li><strong>30 Years of Immunoassay Development and Manufacturing Experience: </strong> Partner with us for your custom immune response profiling needs.</li> </ul></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--clickable-icons-container paragraph--view-mode--default"> <div class="container"> <div class="row"> <div class="col p-0 "> <h2>Explore Immunoassays for Secreted Cytokines</h2> </div> </div> <div class="row"> <div class="col "> </div> </div> <div class="row"> <div class="row"> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#keycytokine" > <div><article> <div><img src='https://resources.bio-techne.com/images/webinar/LP_images/Protein-Bioprocessing-LP-Characterization-Cytokine-v2.png' alt='Protein Bioprocessing: discover the bioactivity of your biologics with our range of solutions.'></div> </article> </div> <p><strong>Key Cytokines</strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#treg" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/DW-Immune-Cell-Therapy-Treg-Cell-STRY0112373.png' alt='Treg Cell Image'></div> </article> </div> <p><strong>Th Cells and Tregs</strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#crs" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/common-cytokine-receptor-gamma-chain-guide-teaser-solo.png' alt='Select immune cell types whose development and activities are regulated by common cytokine receptor gamma chain cytokines '></div> </article> </div> <p><strong>Cytokine Release Syndrome</strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#webinar" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/dw-custom-services-cgt-stry0114989-img2-webinar.jpg' alt='Webinar Image'></div> </article> </div> <p><strong>Webinars</strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#resources" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/elisa-hs-immunoassays-ifn-gamma-secretion-cytokine-storm-app-note.jpg' alt='ELISA High Sensitivity Immunoassays'></div> </article> </div> <p><strong>Resources</strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#custom" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/obt-antibody-luminex-new.png' alt='Custom Luminex assay antibody, analyte and species options'></div> </article> </div> <p><strong>Custom Services</strong></p> </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <h2>Choose the Assay That Best Suits Your Immune Response Profiling Needs</h2> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/reagents/simple-plex-immunoassays" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/instruments/instrument-ella-500x382.png" alt="Ella Instrument Simple Plex" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/reagents/simple-plex-immunoassays" > <h3 class="card_title_htag"> <div><h3>Simple Plex™ Immunoassays</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>This hands-free, automated immunoassay has factory-built standards, allowing for easy comparisons across users and geographies. Quantify up to 8 target analytes simultaneously in 90 minutes!</p></div> </div> <div class="card-bottom-link"> <div> <a href="/reagents/simple-plex-immunoassays" > Explore Simple Plex Automated Immunoassays </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/resources/instrument-applications/sars-cov-2-multi-antigen-serology-module-simple-western" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/instruments/instrument-obt-teaser-jess-700x420-v2.png" alt="Jess Instrument Simple Western" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/instrument-applications/sars-cov-2-multi-antigen-serology-module-simple-western" > <h3 class="card_title_htag"> <div><h3>Simple Western Serology Assays</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Hands-free serology assays on Simple Western add size separation for quantitative immune response profiling of multiple antigens simultaneously with just 3 µL of serum sample.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/instrument-applications/sars-cov-2-multi-antigen-serology-module-simple-western" > Explore Multi-Antigen Serological Assays </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/reagents/luminex-assays" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/bt-luminexassay-gradient-hero-cell-v3.png" alt="Luminex Assay Gradient Hero Cell" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/reagents/luminex-assays" > <h3 class="card_title_htag"> <div><h3>Luminex<sup>®</sup> Assays</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Use this flexible, cost-effective multiplex assay to quantify up to 50 analytes per sample in cell culture supernates, serum, plasma, and other fluids. Learn More About Luminex Discovery Assays and High-Performance Assays.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/reagents/luminex-assays" > Find Out More About Luminex Assays </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/reagents/elisa-kits" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/vaccine-lp-assess-elisa.png" alt="Antibody binding antigen in sandwich ELISA " loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/reagents/elisa-kits" > <h3 class="card_title_htag"> <div><h3>Quantikine™ ELISA Kits</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Quantikine ELISA kits are the most cited ELISA on the market. These vertically integrated ELISAs undergo a rigorous Quality Control/Quality Assurance regimen. Choose Quantikine High Sensitivity ELISAs for low-abundance analytes. </p> <p> </p></div> </div> <div class="card-bottom-link"> <div> <a href="/reagents/elisa-kits" > Explore ELISA </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/reagents/elisa-kits/duoset-elisa-development-kits" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/products/rndsystems_duoset-elisas.png" alt="Image showing R&D Systems DuoSet intracellular IC ELISA kits" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/reagents/elisa-kits/duoset-elisa-development-kits" > <h3 class="card_title_htag"> <div><h3>DuoSet™ ELISAs</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>This flexible ELISA is adaptable to a variety of platforms. It also allows you maximum control over assay conditions. Choose from over 1000 assays across 16 species.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/reagents/elisa-kits/duoset-elisa-development-kits" > Explore DuoSet ELISAs </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/reagents/proteome-profiler-antibody-arrays" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/ia-teaser-floater-6-350x210.png" alt="Proteome Profiler™ Antibody Array" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/reagents/proteome-profiler-antibody-arrays" > <h3 class="card_title_htag"> <div><h3>Proteome Profiler™ Antibody Arrays</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Use this simple, qualitative screening assay to simultaneously measure up to 119 cytokines in supernates and cellular lysates.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/reagents/proteome-profiler-antibody-arrays" > Explore Proteome Profiler Arrays </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Bio-Techne's Immunoassay Platforms are Highly Correlated</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/graphs/b3graphs-immuneprofiling-ifngamma-1110x212.png" alt="Serum IFN-γ detection is highly correlated across Bio-Techne’s immunoassay platforms" loading="lazy" > </div> <div><p>Bio-Techne maintains consistent quality standards across all our immunoassays. This enables you to move seamlessly from one immunoassay platform to the next as your needs change. In this example, serum IFN-γ detection is highly correlated across Bio-Techne’s immunoassay platforms. <strong>A.</strong> The Quantikine High Sensitivity (HS) ELISA is highly correlated with Simple Plex Assay (R<sup>2</sup>=0.99). <strong>B.</strong> Similarly, HS ELISA data is also highly correlated with Luminex assay data (R<sup>2</sup>=0.97). <strong>C.</strong> Finally, data collected using the Simple Plex immunoassay is highly correlated with the Luminex Assay (R<sup>2</sup>=0.98).</p></div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-what-is-immune-response-profiling22" role="button" aria-expanded="false" aria-controls="expPara"> <h5>What is Immune Response Profiling?</h5> </a> </div> <div class="collapse" id="expPara-what-is-immune-response-profiling22" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>The vertebrate immune system's role is to protect against pathogenic organisms such as viruses or bacteria. It also protects against aberrant cells and plays a role in tissue maintenance and repair<sup>1</sup>. Investigators use immune response profiling to capture a snapshot of immune system activity in healthy and pathological contexts.  Immune response profiling can include assessments of immune cell phenotye, cellular activity, and secreted products such as cytokines and antibodies. This page highlights immunoassays for quantifying secreted cytokines.</p></div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="keycytokine"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Purchase Key Cytokine Immunoassays</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>Bio-Techne has over 1000 immunoassays for immune response profiling. Are you running a Luminex assay? Use the <a href="/luminex-assay-customization-tool"><strong>Luminex Assay Customization Tool</strong></a> to design and purchase your assay. Running an ELISA, ELISpot, or Array? Use the search bar above to find the immunoassay that best suits your needs. We have listed key cytokines below for your convenience.</p></div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-luminex-fixed-and-configurable-panels25" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Luminex Fixed and Configurable Panels</h5> </a> </div> <div class="collapse" id="expPara-luminex-fixed-and-configurable-panels25" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/luminex-3d-dc-hero-updated.jpg" alt="Luminex bead antibody binding analyte in Luminex multiplex assay" loading="lazy" > </div> <br/> <div><h3>Luminex Human Discovery Assays - Preconfigured Panels</h3> <p><strong>Luminex Discovery assays are ideal for early-stage discovery or screening. Use the <a href="/luminex-assay-customization-tool">Luminex Assay Customization Tool</a> or adapt the preconfigured panels below to meet your specific needs.</strong></p> <ul> <li><a href="/luminex-assay-customization-tool?code=BpDbuyDMh">CD8 T Cell</a></li> <li><a href="/luminex-assay-customization-tool?code=Bdk3Hhgb7">Cytokine/Chemokine</a></li> <li><a href="/luminex-assay-customization-tool?code=B7WvAnXJB">Cytokine/Chemokine 2</a></li> <li><a href="/luminex-assay-customization-tool?code=BmpQUzyxy">Sepsis</a></li> <li><a href="/luminex-assay-customization-tool?code=BmnYwd8h4">Sepsis 2</a></li> <li><a href="/luminex-assay-customization-tool?code=BgVjn84Fj">Soluble Cytokines</a></li> <li><a href="/luminex-assay-customization-tool?code=BZ84Mydxu">T Cell</a></li> <li><a href="/luminex-assay-customization-tool?code=BB9LrBYyN">Th1/Th2</a></li> <li><a href="/luminex-assay-customization-tool?code=BFRdAPhXa">Th 17</a></li> </ul> <h3>High Performance - Fixed Luminex Panels</h3> <p><strong>High Performance Luminex assays are ideal for late-stage target analyte verification. Fixed panels come with pre-selected analytes and are ready to use. </strong></p> <p><strong>Stocked, Ships in 1-2 Days</strong></p> <ul> <li> <p><a href="/p/luminex-assays/human-cytokine-magnetic-luminex-performance-assay-14-plex-fixed-panel_lktm011">Human Cytokine 14-plex</a></p> </li> <li> <p><a href="/p/luminex-assays/human-chemokine-magnetic-luminex-performance-assay-8-plex-fixed-panel_lktm012">Human Chemokine 8-plex</a></p> </li> <li> <p><a href="/p/luminex-assays/human-growth-factor-magnetic-luminex-performance-assay-21-plex-fixed-panel_lktm013">Human Growth Factor 21-plex</a></p> </li> <li> <p><a href="/p/luminex-assays/human-th1-th2-magnetic-luminex-performance-assay-11-plex-fixed-panel_lktm008">Human Th1/Th2 11-plex</a></p> </li> <li> <p><a href="/p/luminex-assays/human-th9-th17-th22-magnetic-luminex-performance-assay-17-plex-fixed-panel_lktm009">Human Th9/Th17/Th22 17-plex</a></p> </li> <li> <p><a href="/p/luminex-assays/human-timp-magnetic-luminex-performance-assay-4-plex-fixed-panel_lktm003">Human TIMP 4-plex</a></p> </li> <li> <p><a href="/p/luminex-assays/human-xl-cytokine-magnetic-luminex-performance-assay-44-plex-fixed-panel_lktm014">Human XL Cytokine 44-plex</a></p> </li> </ul> <h3>High Performance - Configurable Luminex Panels</h3> <p><strong>High Performance Configurable Luminex Panels allow you to customize the panel to meet your specific needs. </strong></p> <p><strong>Select Analytes, Ships 5-10 Days</strong></p> <ul> <li> <p><a href="/p/luminex-assays/human-biomarker-premixed-magnetic-luminex-performance-assay-kit-a_fcstm13">Human Biomarker Panel A</a></p> </li> <li> <p><a href="/p/luminex-assays/human-cytokine-a-premixed-magnetic-luminex-performance-assay_fcstm03">Human Cytokine Panel A</a></p> </li> <li> <p><a href="/p/luminex-assays/human-high-sensitivity-cytokine-a-premixed-magnetic-luminex-performance-assay_fcstm09">Human High Sensitivity Cytokine Panel A</a></p> </li> <li> <p><a href="/p/luminex-assays/human-high-sensitivity-cytokine-b-premixed-magnetic-luminex-performance-assay_fcstm14">Human High Sensitivity Cytokine Panel B</a></p> </li> <li> <p><a href="/p/luminex-assays/human-xl-cytokine-luminex-performance-panel-premixed-kit_fcstm18">Human XL Cytokine Panel</a></p> </li> <li> <p><a href="/p/luminex-assays/nhp-xl-cytokine-luminex-performance-premixed-kit_fcstm21">NHP XL Cytokine Panel</a></p> </li> <li> <p><a href="/p/luminex-assays/tgf-beta-premixed-magnetic-luminex-performance-assay_fcstm17">Multi-species TGF-beta Panel</a></p> </li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-simple-plex-stocked-cartridges-and-panels22" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Simple Plex Stocked Cartridges and Panels</h5> </a> </div> <div class="collapse" id="expPara-simple-plex-stocked-cartridges-and-panels22" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>These ready-to-use Simple Plex cartridges ship within the continental United States within 48 hours. Choose from single analyte assays, Cytokine Storm panel, Coagulation Panels, or the Cytokine Screening Panel. Need a customized panel for your study? <strong><a href="/p/instruments/simple-plex/request-quote?productName=Ella&catalogNumber=600-100">Your local immunoassay specialist is standing by to help!</a></strong></p></div> <a href="/reagents/simple-plex-immunoassays/simple-plex-stocked-cartridges" class="btn btn-primary" type="link"> Purchase Simple Plex Stocked Cartridges </a> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-key-cytokine-immunoassays18" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Key Cytokine Immunoassays</h5> </a> </div> <div class="collapse" id="expPara-key-cytokine-immunoassays18" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li>IFN-gamma       <a href="/search?keywords=interferon%20gamma&category_attr=Luminex%20Assays&common_name=IFN-gamma">Luminex Assays</a> | <a href="/t/ifn-gamma/simple-plex">Simple Plex Assays</a> | <a href="/t/ifn-gamma/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=interferon%20gamma&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> | <a href="/search?keywords=interferon%20gamma&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> <li>IL-1b                   <a href="/search?keywords=IL-1%20beta&category_attr=Luminex%20Assays&common_name=IL-1%20beta/IL-1F2">Luminex Assays</a> | <a href="/search?keywords=il1%20beta&brand=proteinsimple&common_name=IL-1%20beta/IL-1F2">Simple Plex Assays</a> | <a href="/search?keywords=IL-1-beta&category_attr=ELISA%20Kits">ELISA Kits</a> | <a href="/search?keywords=il1%20beta&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-1%20beta/IL-1F2">Proteome Profiler Arrays</a></li> <li>IL-2                     <a href="/search?keywords=IL-2&category_attr=Luminex%20Assays&common_name=IL-2">Luminex Assays</a> | <a href="/t/il-2/simple-plex">Simple Plex Assays</a> | <a href="/t/il-2/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il2&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-2">Proteome Profiler Arrays</a> | <a href="/search?keywords=il2&category_attr=ELISpot%20and%20FluoroSpot%20Kits&common_name=IL-2">ELISpot Kits</a></li> <li>IL-6                     <a href="/search?keywords=IL-6&category_attr=Luminex%20Assays&common_name=IL-6">Luminex Assays</a> | <a href="/t/il-6/simple-plex">Simple Plex Assays</a> | <a href="/t/il-6/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il6&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-6">Proteome Profiler Arrays</a>| <a href="/search?keywords=il6&category_attr=ELISpot%20and%20FluoroSpot%20Kits&common_name=IL-6">ELISpot Kits</a></li> <li>IL-8                     <a href="/search?keywords=IL-8&category_attr=Luminex%20Assays&common_name=IL-8/CXCL8">Luminex Assays </a>| <a href="/search?keywords=il8&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-8-cxcl8/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il8&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-8/CXCL8">Proteome Profiler Arrays</a> </li> <li>IL-10                   <a href="/search?keywords=IL-10&category_attr=Luminex%20Assays&common_name=IL-10">Luminex Assays</a> | <a href="/search?keywords=il10&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-10/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il10&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-10">Proteome Profiler Arrays</a> | <a href="/search?keywords=il10&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> <li>IL-18                   <a href="/search?keywords=IL-18&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/t/il-18-il-1f4/simple-plex">Simple Plex Assays</a> | <a href="/t/il-18-il-1f4/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il18&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-18%20R%20alpha/IL-1%20R5|IL-18%20BPa|IL-18/IL-1F4">Proteome Profiler Arrays</a> </li> <li>TNF-alpha          <a href="/search?keywords=TNF-alpha&category_attr=Luminex%20Assays&common_name=TNF-alpha">Luminex Assays</a> | <a href="/search?keywords=tnfalpha&brand=proteinsimple&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/tnf-alpha/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=tnfalpha&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=TNF-alpha">Proteome Profiler Arrays</a> | <a href="/search?keywords=tnfalpha&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="treg"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Profile Cytokines Secreted by Helper T Cells and Regulatory T Cells</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>CD4<sup>+</sup> T cells are subclassified into helper T (Th) cells and regulatory T cells based on their cytokine repertoire<sup>2</sup>. Although Th1 secreted cytokines are associated with proinflammatory and antitumor responses, Th2 secreted cytokines are correlated with anti-inflammatory responses. Th17 responses play a role in autoimmunity and allergic responses. Finally, Tregs suppress deleterious Th cell activity. It is no surprise that cytokines secreted by Tregs are associated with immunosuppression and cancer progression.</p></div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-profile-cytokines-secreted-by-th1-cells12" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Profile Cytokines Secreted by Th1 Cells</h5> </a> </div> <div class="collapse" id="expPara-profile-cytokines-secreted-by-th1-cells12" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li><strong>IFN-gamma</strong>     <a href="/search?keywords=interferon%20gamma&category_attr=Luminex%20Assays&common_name=IFN-gamma">Luminex Assays</a> | <a href="/t/ifn-gamma/simple-plex">Simple Plex Assays</a> | <a href="/t/ifn-gamma/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=interferon%20gamma&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> | <a href="/search?keywords=interferon%20gamma&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> <li><strong>IL-2 </strong>                   <a href="/search?keywords=IL-2&category_attr=Luminex%20Assays&common_name=IL-2">Luminex Assays</a> | <a href="/t/il-2/simple-plex">Simple Plex Assays</a> | <a href="/t/il-2/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il2&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-2">Proteome Profiler Arrays</a> | <a href="/search?keywords=il2&category_attr=ELISpot%20and%20FluoroSpot%20Kits&common_name=IL-2">ELISpot Kits</a></li> <li><strong>IL-12                  </strong><a href="/search?keywords=IL-12&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il12&brand=proteinsimple">Simple Plex Assays</a> | <a href="/search?keywords=IL-12&category_attr=ELISA%20Kits">ELISA Kits</a> | <a href="/search?keywords=il12&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a>  | <a href="/p/elispot-fluorospot-kits/human-il-12-il-23-p40-elispot-kit_el309">ELISpot Kit</a></li> <li><strong>TNF-alpha        </strong><a href="/search?keywords=tnf-alpha&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=tnfalpha&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=TNF-alpha&category_attr=ELISA%20Kits">ELISA Kits</a> |<a href="/search?keywords=tnfalpha&category_attr=Proteome%20Profiler%20Antibody%20Arrays"> Proteome Profiler Arrays</a> | <a href="/search?keywords=tnfalpha&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-profile-cytokines-secreted-by-th2-cells14" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Profile Cytokines Secreted by Th2 Cells</h5> </a> </div> <div class="collapse" id="expPara-profile-cytokines-secreted-by-th2-cells14" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li><strong>IL-4                        </strong><a href="/search?keywords=IL-4&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il4&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-4/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il4&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> |<a href="/search?keywords=il4&category_attr=ELISpot%20and%20FluoroSpot%20Kits"> ELIspot Kits</a></li> <li><strong>IL-5                        </strong><a href="/search?keywords=IL-5&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il5&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=IL-5&category_attr=ELISA%20Kits">ELISA Kits</a> | <a href="/search?keywords=il5&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> | <a href="/search?keywords=il5&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> <li><strong>IL-6                        </strong><a href="/t/il-6r-alpha/luminex-assays">Luminex Assays</a> | <a href="/t/il-6/simple-plex">Simple Plex Assays</a> | <a href="/t/il-6/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il6&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-6">Proteome Profiler Arrays</a>| <a href="/search?keywords=il6&category_attr=ELISpot%20and%20FluoroSpot%20Kits&common_name=IL-6">ELISpot Kits</a></li> <li><strong>IL-10</strong>                      <a href="/search?keywords=IL-10&category_attr=Luminex%20Assays&common_name=IL-10">Luminex Assays</a> | <a href="/search?keywords=il10&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-10/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il10&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-10">Proteome Profiler Arrays</a> | <a href="/search?keywords=il10&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> <li><strong>IL-13                      </strong><a href="/search?keywords=IL-13&category_attr=Luminex%20Assays">Luminex Assays</a> |<a href="/search?keywords=il13&brand=proteinsimple&category_attr=Simple%20Plex"> Simple Plex Assays</a> |<a href="/search?keywords=IL-13&category_attr=ELISA%20Kits"> ELISA Kits</a>| <a href="/search?keywords=il13&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> | <a href="/search?keywords=il13&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-profile-cytokines-secreted-by-th17-cells14" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Profile Cytokines Secreted by Th17 Cells</h5> </a> </div> <div class="collapse" id="expPara-profile-cytokines-secreted-by-th17-cells14" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li><strong>IL-17</strong>            <a href="/search?keywords=IL-17&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il17&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=IL-17&category_attr=ELISA%20Kits">ELISA Kits</a>| <a href="/search?keywords=il17&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> | <a href="/search?keywords=il17&category_attr=ELISpot%20and%20FluoroSpot%20Kits">Elispot Kits</a></li> <li><strong>IL-21</strong>            <a href="/search?keywords=il21&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il21&category_attr=ELISA%20Kits">DuoSet ELISAs</a> | <a href="/search?keywords=il21&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Antibody Array</a> </li> <li><strong>IL-22           </strong><a href="/search?keywords=IL-22&category_attr=Luminex%20Assays"> Luminex Assays</a> | <a href="/search?keywords=il22&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=IL-22&category_attr=ELISA%20Kits">ELISA Kits</a> |<a href="/search?keywords=il22&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> </li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-profile-cytokines-secreted-by-regulatory-t-cells-tregs9" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Profile Cytokines Secreted by Regulatory T Cells (Tregs)</h5> </a> </div> <div class="collapse" id="expPara-profile-cytokines-secreted-by-regulatory-t-cells-tregs9" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li><strong>TGF-beta  </strong>       <a href="/search?keywords=tgf-%20beta&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=tgf%20beta&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/tgf-beta-1/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=tgf%20beta&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Array</a> </li> <li><strong>IL-10</strong>                 <a href="/search?keywords=IL-10&category_attr=Luminex%20Assays&common_name=IL-10">Luminex Assays</a> | <a href="/search?keywords=il10&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-10/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il10&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-10">Proteome Profiler Arrays</a> | <a href="/search?keywords=il10&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kit</a></li> <li><strong>IL-35                </strong> <a href="/p/elisa-kits/human-ebi3-duoset-elisa_dy6456-05">DuoSet ELISA</a></li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="crs"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Cytokine Release Syndrome Profiling</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>Cytokine release syndrome (CRS), also known as the cytokine storm, is a life-threatening systemic inflammatory syndrome.  It is characterized by the excessive release of cytokines<sup>3</sup>. CRS is triggered by a variety of events, including cancer, cell therapy, and infections triggered by bacteria or viruses.</p></div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-immunoassays-for-cell-therapy-and-crs-immune-response-profiling23" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Immunoassays for Cell Therapy and CRS Immune Response Profiling</h5> </a> </div> <div class="collapse" id="expPara-immunoassays-for-cell-therapy-and-crs-immune-response-profiling23" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>Cell Therapy stimulated CRS is characterized by the excessive release of cytokines including<sup>4</sup>:</p> <ul> <li><strong>IFN-gamma</strong>    <a href="/search?keywords=interferon%20gamma&category_attr=Luminex%20Assays&common_name=IFN-gamma">Luminex Assays</a> | <a href="/t/ifn-gamma/simple-plex">Simple Plex Assays</a> | <a href="/t/ifn-gamma/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=interferon%20gamma&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> | <a href="/search?keywords=interferon%20gamma&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> <li><strong>IL-6</strong>                   <a href="/t/il-6r-alpha/luminex-assays">Luminex Assays</a> | <a href="/t/il-6/simple-plex">Simple Plex Assays</a> | <a href="/t/il-6/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il6&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-6">Proteome Profiler Arrays</a>| <a href="/search?keywords=il6&category_attr=ELISpot%20and%20FluoroSpot%20Kits&common_name=IL-6">ELISpot Kits</a></li> <li><strong>IL-8  </strong>                 <a href="/search?keywords=IL-8&category_attr=Luminex%20Assays&common_name=IL-8/CXCL8">Luminex Assays </a>| <a href="/search?keywords=il8&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-8-cxcl8/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il8&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-8/CXCL8">Proteome Profiler Arrays</a> </li> <li><strong>IL-10</strong>                 <a href="/search?keywords=IL-10&category_attr=Luminex%20Assays&common_name=IL-10">Luminex Assays</a> | <a href="/search?keywords=il10&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-10/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il10&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-10">Proteome Profiler Arrays</a> | <a href="/search?keywords=il10&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> <li><strong>IL-15  </strong>               <a href="/search?keywords=IL-15&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il15&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-15/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il15&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a></li> <li><strong>MCP-1</strong>             <a href="/search?keywords=il15&category_attr=Luminex%20Assays"> Luminex Assays</a> | <a href="/search?keywords=MCP-1&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=MCP-1&category_attr=ELISA%20Kits">ELISA Kits</a> | <a href="/search?keywords=mcp1&sub_category=Proteome%20Profiler%20Antibody%20Array%20Kits">Proteome Profiler Arrays</a></li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-immunoassays-for-covid-19-and-crs-immune-response-profiling1" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Immunoassays for COVID-19 and CRS Immune Response Profiling</h5> </a> </div> <div class="collapse" id="expPara-immunoassays-for-covid-19-and-crs-immune-response-profiling1" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>Severe COVID-19 disease can be characterized by CRS. Cytokines elevated in COVID-stimulated CRS include<sup>5</sup>:</p> <ul> <li><strong>G-CSF</strong>                  <a href="/search?keywords=G-csf&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/t/g-csf/simple-plex">Simple Plex Assays</a> | <a href="/t/g-csf/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=gcsf&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a></li> <li><strong>GM-CSF               </strong><a href="/search?keywords=GM-CSF&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=gmcsf&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=GM-csf&category_attr=ELISA%20Kits">ELISA Kits</a>| <a href="/search?keywords=gmcsf&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a></li> <li><strong>IFN-gamma</strong>        <a href="/search?keywords=interferon%20gamma&category_attr=Luminex%20Assays&common_name=IFN-gamma">Luminex Assays</a> |<a href="/t/ifn-gamma/simple-plex">Simple Plex Assays</a> | <a href="/t/ifn-gamma/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=interferon%20gamma&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> | <a href="/search?keywords=interferon%20gamma&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> <li><strong>IL-1 beta           <a href="/search?keywords=IL-1%20beta&category_attr=Luminex%20Assays"> </a> </strong><a href="/search?keywords=IL-1%20beta&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il1%20beta&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=IL-1-beta&category_attr=ELISA%20Kits">ELISA Kits</a> | <a href="/search?keywords=il1%20beta&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> </li> <li><strong>IL-6                       </strong><a href="/t/il-6r-alpha/luminex-assays">Luminex Assays</a> | <a href="/t/il-6/simple-plex">Simple Plex Assays</a> | <a href="/t/il-6/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il6&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-6">Proteome Profiler Arrays</a>| <a href="/search?keywords=il6&category_attr=ELISpot%20and%20FluoroSpot%20Kits&common_name=IL-6">ELISpot Kits</a></li> <li><strong>IL-7                       </strong><a href="/search?keywords=IL-7&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il7&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-7/elisa-kits">ELISA Kits</a></li> <li><strong>IL-8  </strong>                     <a href="/search?keywords=IL-8&category_attr=Luminex%20Assays&common_name=IL-8/CXCL8">Luminex Assays </a>| <a href="/search?keywords=il8&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-8-cxcl8/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il8&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-8/CXCL8">Proteome Profiler Arrays</a> </li> <li><strong>IL-9                       </strong><a href="/search?keywords=IL-9&sub_category=DuoSet%20ELISA%20Development%20Systems">DuoSet ELISAs</a></li> <li><strong>IL-10                     </strong><a href="/search?keywords=IL-10&sub_category=Luminex%20High%20Performance%20Assays">Luminex Assays</a> | <a href="/search?keywords=il10&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-10/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il10&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> | <a href="/search?keywords=il10&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> <li><strong>IL-17                     </strong><a href="/search?keywords=IL-17&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il17&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-17-il-17a/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il17&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> | <a href="/search?keywords=il17&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> <li><strong>MCP-1</strong>             <a href="/search?keywords=il15&category_attr=Luminex%20Assays">     Luminex Assays</a> | <a href="/search?keywords=MCP-1&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=MCP-1&category_attr=ELISA%20Kits">ELISA Kits</a> | <a href="/search?keywords=mcp1&sub_category=Proteome%20Profiler%20Antibody%20Array%20Kits">Proteome Profiler Arrays</a></li> <li><strong>TNF-alpha           </strong><a href="/search?keywords=tnf-alpha&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=tnfalpha&category_attr=Simple%20Plex">Simple Plex Assays</a> |<a href="/search?keywords=TNF-alpha&category_attr=ELISA%20Kits">ELISA Kits</a> |<a href="/search?keywords=tnfalpha&category_attr=Proteome%20Profiler%20Antibody%20Arrays"> Proteome Profiler Arrays</a> | <a href="/search?keywords=tnfalpha&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> </ul> <p>Tocilizumab and Sarilumab have been encouraged for the treatment of critically ill COVID-19 patients. Bio-Techne has<strong> </strong><a href="/p/antibodies/human-il-6r-alpha-research-grade-sarilumab-biosimilar-antibody-hu137_mab10346"><strong>Research Grade Human IL-6R alpha (Sarilumab Biosimilar) antibody</strong></a><strong> </strong>for research applications.</p></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-immunoassays-for-systemic-inflammation-and-crs-immune-response-profiling18" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Immunoassays for Systemic Inflammation and CRS Immune Response Profiling</h5> </a> </div> <div class="collapse" id="expPara-immunoassays-for-systemic-inflammation-and-crs-immune-response-profiling18" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>Systemic inflammatory responses and CRS can be triggered by a variety of stressors including, infection, trauma, ischemia, and more<sup>6</sup>.</p> <ul> <li><strong>CRP                        </strong><a href="/search?keywords=CRP&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=crp&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=CRP&category_attr=ELISA%20Kits">ELISA Kits</a> | <a href="/search?keywords=crp&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays </a></li> <li><strong>IFN-gamma</strong>         <a href="/search?keywords=interferon%20gamma&category_attr=Luminex%20Assays&common_name=IFN-gamma">Luminex Assays</a> | <a href="/t/ifn-gamma/simple-plex">Simple Plex Assays</a> | <a href="/t/ifn-gamma/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=interferon%20gamma&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> | <a href="/search?keywords=interferon%20gamma&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> <li><strong>IL-1</strong>                        <a href="/search?keywords=IL-1&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il1&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=IL-1&category_attr=ELISA%20Kits">ELISA Kits</a> | <a href="/search?keywords=il1&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a></li> <li><strong>IL-1 beta              </strong><a href="/search?keywords=IL-1%20beta&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il1%20beta&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=IL-1beta&category_attr=ELISA%20Kits">ELISA Kits</a>| <a href="/search?keywords=il1%20beta&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a></li> <li><strong>IL-4                        </strong><a href="/search?keywords=IL-4&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=il4&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-4/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il4&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> |<a href="/search?keywords=il4&category_attr=ELISpot%20and%20FluoroSpot%20Kits"> ELIspot Kits</a></li> <li><strong>IL-6                        </strong><a href="/t/il-6r-alpha/luminex-assays">Luminex Assays</a> | <a href="/t/il-6/simple-plex">Simple Plex Assays</a> | <a href="/t/il-6/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il6&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-6">Proteome Profiler Arrays</a>| <a href="/search?keywords=il6&category_attr=ELISpot%20and%20FluoroSpot%20Kits&common_name=IL-6">ELISpot Kits</a></li> <li><strong>IL-8  </strong>                      <a href="/search?keywords=IL-8&category_attr=Luminex%20Assays&common_name=IL-8/CXCL8">Luminex Assays </a>| <a href="/search?keywords=il8&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-8-cxcl8/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il8&category_attr=Proteome%20Profiler%20Antibody%20Arrays&common_name=IL-8/CXCL8">Proteome Profiler Arrays</a> </li> <li><strong>IL-10                      </strong><a href="/search?keywords=IL-10&sub_category=Luminex%20High%20Performance%20Assays">Luminex Assays</a> | <a href="/search?keywords=il10&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/t/il-10/elisa-kits">ELISA Kits</a> | <a href="/search?keywords=il10&category_attr=Proteome%20Profiler%20Antibody%20Arrays">Proteome Profiler Arrays</a> | <a href="/search?keywords=il10&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a><strong> </strong></li> <li><strong>TNF-alpha</strong>          <strong>  </strong><a href="/search?keywords=tnf-alpha&category_attr=Luminex%20Assays">Luminex Assays</a> | <a href="/search?keywords=tnfalpha&category_attr=Simple%20Plex">Simple Plex Assays</a> | <a href="/search?keywords=TNF-alpha&category_attr=ELISA%20Kits">ELISA Kits</a> |<a href="/search?keywords=tnfalpha&category_attr=Proteome%20Profiler%20Antibody%20Arrays"> Proteome Profiler Arrays</a> | <a href="/search?keywords=tnfalpha&category_attr=ELISpot%20and%20FluoroSpot%20Kits">ELISpot Kits</a></li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph-image-banner banner_wrapper"> <div class="banner_background_image" data-bgimage="https://resources.bio-techne.com/images/webinar/LP_images/Covid-Vaccine-LP-Hero-Background.png" style="background-repeat: no-repeat"> <div class="text_align_center"> <div><h2>Vaccine Research and Development</h2></div> <div><p><strong>Develop the highest quality vaccines with solutions that save time and money while providing superb accuracy and precision.</strong></p></div> <a href="/applications/vaccine-development" > <button type="button" class="btn btn-primary"> Learn More About Vaccine Research and Development </button> </a> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Immune Response Profiling Publication Spotlights</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>Download these publications to see how your peers are using Bio-Techne's immunoassays in scientific and clinical research studies.</p></div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-covid-19-vaccination-in-fragile-patients-current-evidence-and-an-harmonized-transdisease-trial16" role="button" aria-expanded="false" aria-controls="expPara"> <h5>COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial</h5> </a> </div> <div class="collapse" id="expPara-covid-19-vaccination-in-fragile-patients-current-evidence-and-an-harmonized-transdisease-trial16" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>Individuals with pre-existing conditions are often excluded from COVID-19 vaccine trials, creating a gap in our understanding of vaccine efficacy. To address this issue, 12 Italian healthcare centers collaborated to understand vaccine efficacy in a large transdisease cohort that was excluded from vaccine trials. Download this publication to see how <strong><a href="/reagents/simple-plex-immunoassays">Simple Plex</a></strong> automated immune response profiling assays were used in the VAX4FRAIL study.</p></div> <a href="https://www.frontiersin.org/articles/10.3389/fimmu.2021.704110/full" class="btn btn-primary" type="link"> Read the VAX4FRAIL Study </a> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-acetylated-k676-tgfbip-as-a-severity-diagnostic-blood-biomarker-for-sars-cov-2-pneumonia2" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia</h5> </a> </div> <div class="collapse" id="expPara-acetylated-k676-tgfbip-as-a-severity-diagnostic-blood-biomarker-for-sars-cov-2-pneumonia2" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>In this peer-reviewed Science Advances paper, investigators used  <strong><a href="/reagents/elisa-kits/quantikine">Quantikine™ ELISAs</a></strong> and <strong><a href="/reagents/proteome-profiler-antibody-arrays">Proteome Profiler™ Antibody Arrays</a></strong> to understand the relationship between a novel biomarker candidate, acetylated 676th lysine transforming growth factor–beta-induced protein (TGFBIp K676Ac), the cytokine storm, and COVID-19 severity. Download our <a href="https://resources.rndsystems.com/images/site/sp_elisapublicationspotlight_stry0062546_web.pdf" target="_blank">publication spotlight</a>, highlighting this paper on R&D Systems.com.</p></div> <a href="https://www.science.org/doi/10.1126/sciadv.abc1564" class="btn btn-primary" type="link"> Download the SARS-CoV-2 Biomarker Publication </a> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-similarities-and-differences-between-the-cytokine-storms-in-acute-dengue-and-covid-1911" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Similarities and differences between the ‘cytokine storms’ in acute dengue and COVID-19</h5> </a> </div> <div class="collapse" id="expPara-similarities-and-differences-between-the-cytokine-storms-in-acute-dengue-and-covid-1911" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>In this Nature paper, investigators used <strong><a href="/reagents/simple-plex-immunoassays">Simple Plex immunoassays</a></strong> and the <strong><a href="/p/luminex-assays/human-th9-th17-th22-magnetic-luminex-performance-assay-17-plex-fixed-panel_lktm009">R&D Systems Th9/Th17/Th 22 Discovery Performance Assay</a></strong> to profile cytokines in patients with COVID-19 and dengue haemorrhagic fever (DHF). Their data indicate that these patients have a complex cytokine milieu that varies as a function of disease type and progression. Download the publication to learn more.</p></div> <a href="https://www.nature.com/articles/s41598-020-76836-2" class="btn btn-primary" type="link"> Download the Cytokine Storms in COVID-19 and DHF Publication </a> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-marked-t-cell-activation-senescence-exhaustion-and-skewing-towards-th17-in-patients-with-covid-19-pneumonia25" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia</h5> </a> </div> <div class="collapse" id="expPara-marked-t-cell-activation-senescence-exhaustion-and-skewing-towards-th17-in-patients-with-covid-19-pneumonia25" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>SARS-CoV-2 pathophysiology is incompletely understood. To address this issue, De Biasi <em>et al.,</em> examined the T cell compartment in severe COVID-19 patients. The authors used the <strong><a href="/p/luminex-assays/human-luminex-discovery-assay_lxsahm">Human Cytokine Discovery Panel</a></strong> to profile 31 cytokines in severe COVID-19 patients. Their data highlighted, among other things, the importance of IL-17 in severe COVID-19 patients.</p></div> <a href="https://www.nature.com/articles/s41467-020-17292-4" class="btn btn-primary" type="link"> Download the Th17 and COVID Publication </a> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-t-cell-immune-response-after-mrna-sars-cov-2-vaccines-is-frequently-detected-also-in-the-absence-of-seroconversion-in-patients-with-lymphoid-malignancies5" role="button" aria-expanded="false" aria-controls="expPara"> <h5>T-cell immune response after mRNA SARS-CoV-2 vaccines is frequently detected also in the absence of seroconversion in patients with lymphoid malignancies</h5> </a> </div> <div class="collapse" id="expPara-t-cell-immune-response-after-mrna-sars-cov-2-vaccines-is-frequently-detected-also-in-the-absence-of-seroconversion-in-patients-with-lymphoid-malignancies5" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>Individuals with lymphoid malignancies (LM) were not included in SARS-CoV-2 mRNA vaccine clinical trials. Since vaccines have reduced efficacy in LM patients, Marasco <em>et al.,</em> wanted to evaluate the immune response to the novel SARs-CoV-2 mRNA vaccines. Download this publication to see how the authors used <strong><a href="/instruments/simple-plex">Ella</a></strong> to profile Th1 associated cytokine release in LM patients that received the Moderna mRNA1273 or Pfizer BNT162b2 mRNA vaccines. </p></div> <a href="https://onlinelibrary.wiley.com/doi/10.1111/bjh.17877" class="btn btn-primary" type="link"> Download the Lymphoid Malignancy and Vaccine Immune Response Publication </a> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-coordinated-cellular-and-humoral-immune-responses-after-two-dose-sars-cov2-mrna-vaccination-in-liver-transplant-recipients5" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Coordinated cellular and humoral immune responses after two-dose SARS-CoV2 mRNA vaccination in liver transplant recipients</h5> </a> </div> <div class="collapse" id="expPara-coordinated-cellular-and-humoral-immune-responses-after-two-dose-sars-cov2-mrna-vaccination-in-liver-transplant-recipients5" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>Investigators do not have a complete understanding of the risks and benefits of SARS-CoV-2 vaccination for solid organ transplant patients. To address this issue, D'Offizi <em>et al., </em>profiled the immune response to the SARS-CoV-2 mRNA vaccine in liver transplant recipients. Download this publication to see how the authors used <strong><a href="/reagents/simple-plex-immunoassays">Simple Plex assays</a></strong> on the <strong><a href="/instruments/simple-plex">Ella</a></strong> platform to profile the Th 1-associated response to SARS-CoV2 mRNA vaccines in liver transplant recipients.</p></div> <a href="https://onlinelibrary.wiley.com/doi/10.1111/liv.15089" class="btn btn-primary" type="link"> Download the SARS-CoV-2 Immune Response in Liver Transplant Patients </a> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-humoral-and-t-cell-specific-immune-responses-to-sars-cov-2-mrna-vaccination-in-patients-with-ms-using-different-disease-modifying-therapies22" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Humoral- and T-Cell Specific Immune Responses to SARS-CoV-2 mRNA Vaccination in Patients With MS Using Different Disease-Modifying Therapies</h5> </a> </div> <div class="collapse" id="expPara-humoral-and-t-cell-specific-immune-responses-to-sars-cov-2-mrna-vaccination-in-patients-with-ms-using-different-disease-modifying-therapies22" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>The impact of disease-modifying treatments (DMTs) for multiple sclerosis (MS) on immune responses to the SARS-CoV-2 vaccine efficacy is unknown. To address this issue, Tortorella <em>et al.,</em> profiled serological and T cell responses in MS patients that received DMTs. Download the publication to see how the authors used <a href="/reagents/simple-plex-immunoassays"><strong>Simple Plex immunoassays</strong></a> to profile serum <strong><a href="/search?keywords=ifn%20gamma&brand=proteinsimple">IFN-gamma</a></strong>.</p></div> <a href="https://n.neurology.org/content/early/2021/11/22/WNL.0000000000013108.long" class="btn btn-primary" type="link"> Download the Immune Profiling in MS Patients Publication </a> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="webinar"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Immune Response Profiling Webinars</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <a href="https://www.bio-techne.com/resources/webinars/profiling-host-response-covid-19-with-ella" title="Watch the COVID-19 Immune Response Profiling Webinar" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/coronavirus-sars-cov-2-covid-350x250.jpg" alt="SARS-CoV-2" loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div><h3>Profile Immune Responses to COVID with Simple Plex Automated Immunoassays</h3></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Watch this webinar to see how Dr. Jesus Bermejo-Marting uses Simple Plex assays on the Ella platform to profile immune responses to COVID-19.</p></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_call_to_action_global"> <a href="/resources/webinars/profiling-host-response-covid-19-with-ella" class="btn btn-primary" type="link"> Watch the COVID-19 Immune Response Profiling Webinar </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <a href="https://www.bio-techne.com/resources/webinars/deep-dive-luminex-multiplex-assays" title="Watch the Luminex Multiplex Assays Video" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/webinars/webinar-luminex-thumbnail-525x315.jpg" alt="Luminex Multiplex Assays " loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div><h3>Deep Dive: Luminex Multiplex Assays at Bio-Techne</h3></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Unfamiliar with Luminex Technology? 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In this video, our scientists demonstrate how our proprietary diluents and reagents preclude the false-positive pitfalls that ensnare assays from competitors.</p></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_call_to_action_global"> <a href="/resources/webinars/webinar-false-positivies-in-immunoassays" class="btn btn-primary" type="link"> Watch the Removing False Positives Webinar </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="resources"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Immune Response Profiling Resources</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <a href="https://www.rndsystems.com/quantify-ifn-gamma-confidence" title="Explore Immunoassays for IFN-gamma Research" target="_blank" rel="noreferrer" > <img src="https://resources.bio-techne.com/images/webinar/LP_images/Protein-Bioprocessing-LP-Characterization-Cytokine-v2.png" alt="Protein Bioprocessing: discover the bioactivity of your biologics with our range of solutions." loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div><h3>Quantify IFN-Gamma With Confidence</h3></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>R&D Systems, a Bio-Techne brand, has an extensive array of Interferon Gamma (IFN-gamma) Immunoassays. Read our IFN-gamma application notes and select the immunoassay that best suits your immune response profiling needs.</p></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_call_to_action_global"> <a href="https://www.rndsystems.com/quantify-ifn-gamma-confidence" class="btn btn-primary" type="link"> Explore Immunoassays for IFN-gamma Research </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h3>Flow Cytometry for Immune Cell Phenotyping</h3></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>Explore Bio-Techne's solutions for Flow Cytometry. Choose from thousands of antibodies and reagents including CyTOF-ready antibodies and multicolor flow cytometry kits. Explore our interactive cell marker tool. Use the Novus Panel Builder to choose compatible reagents.</p></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_call_to_action_global"> <a href="/applications/flow-cytometry" class="btn btn-primary" type="link"> Solutions for Immunophenotyping Using Flow Cytometry </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <a href="https://www.bio-techne.com/applications/flow-cytometry" title="Solutions for Immunophenotyping Using Flow Cytometry" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/flow-cytometry-handbook-teaser-solo.png" alt="Single cell suspended in a population of cells" loading="lazy" > </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4 p-3"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <a href="https://www.bio-techne.com/resources/testimonials/immunassays-profile-immune-system-marker-autoimmune-disease-activity" title="Read the Case Study" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/testimonials/melissamunroe-circle.png" alt="Melissa Munroe" loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_header_2_global"> <div><h2>Gaining an Edge in Autoimmune Disease Research</h2></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p> </p> <h3>“The less we rely on manual steps, the more reproducible the results”</h3> <h4>– Dr. Melissa Munroe, M.D., Ph.D.<br> Research Associate, Oklahoma Medical Research Foundation</h4> <p> </p></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_call_to_action_global"> <a href="/resources/testimonials/immunassays-profile-immune-system-marker-autoimmune-disease-activity" class="btn btn-primary" type="link"> Read the Case Study </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph-image-banner banner_wrapper"> <div class="banner_background_image" data-bgimage="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/immuno-cytokines-banner-1110x800.jpg" style="background-repeat: no-repeat"> <div class="text_align_center"> <div><h2>Cytokines</h2></div> <div><p>From basic research to preclinical applications, we offer research-grade, Animal-Free™, and GMP-grade bioactive cytokines to meet all of your experimental needs.</p></div> <a href="/reagents/proteins/cytokines" > <button type="button" class="btn btn-primary"> Explore Our Large Selection of Cytokines </button> </a> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="custom"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <h2>Custom Immunoassay Services</h2> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/services/custom-elisa-services" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; 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(2014)  </em><a href="https://pubmed.ncbi.nlm.nih.gov/24421210/" target="_blank">Do all creatures possess an acquired immune system of some sort?</a> Bioassays. <strong>36:</strong>273. PMID: 24421210</p> <p>2<strong>. Xu, X,</strong><em> et al</em>, (2016) <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998098/" target="_blank">Expression of Th1- Th2- and Th17-associated cytokines in laryngeal carcinoma</a>. Oncology Letters. <strong>12:</strong>1941. PMID: 27588143</p> <p>3<strong>. Fajgenbaum, D.C. </strong>and<strong> June, C.H.</strong> (2020) <a href="https://www.nejm.org/doi/full/10.1056/NEJMra2026131" target="_blank">Cytokine Storm</a>. NEJM. <strong>383</strong>:2255. PMID: 33264547</p> <p>4. <strong>Neelapu, S.S.</strong> (2019) <a href="https://onlinelibrary.wiley.com/doi/10.1002/hon.2595" target="_blank">Managing the toxicities of CAR T-cell therapy.</a> Hematol. Oncol. <strong>37(S1)</strong>:48. PMID: 31187535</p> <p>5. <strong>Pasrija, R</strong>. and <strong>Naime, M</strong>. (2021) <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691139/" target="_blank">The deregulated immune reaction and cytokines release storm (CRS) in COVID-19 disease</a>. Intl. Immunopharmacology. <strong>90:</strong>107225. PMID: 33302033</p> <p>6. <a href="https://www.ncbi.nlm.nih.gov/books/NBK547669/" target="_blank">https://www.ncbi.nlm.nih.gov/books/NBK547669/</a></p></div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--button-row paragraph--view-mode--default"> <div class="row"> <div class="col"> <div><h3>Explore Related Research Areas</h3></div> <div class="list-grid-wrap"> <div class="row"> <div class="col-md-4"> <a href="/node/466" class="btn btn-primary" type="link"> Immunology </a> </div> <div class="col-md-4"> <a href="/research-areas/immuno-oncology" class="btn btn-primary" type="link"> Immuno-Oncology: Research </a> </div> <div class="col-md-4"> <a href="/applications/immuno-oncology-clinical" class="btn btn-primary" type="link"> Immuno-Oncology: Clinical </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>Luminex<sup>® </sup>is a Registered Trademark of Luminex 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