CINXE.COM

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href="/become-partner">Learn How</a></li></ul></div></div></div></div></li><li class="level0 diagnostics col-1"> <a href="/rnascope%C2%AE-diagnostics" class="level0">Diagnostics</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Diagnostics</div> <span class="sectitle-span">+</span><ul><li><a href="/rnascope%C2%AE-diagnostics">Diagnostics</a></li><li><a href="/diagnostics-literature">Literature</a></li><li><a href="/rnascope%E2%84%A2-ish-probes-detection-kappa-lambda-and-igll5">Diagnostics ASR Probes</a></li><li><a href="/rnascope-ish-probe-high-risk-hpv-head-neck-cancer">Diagnostics CE-IVD Probes</a></li><li><a href="/rnascope-ce-ivd-detection">Diagnostics CE-IVD Detection</a></li><li><a href="/rnascope%C2%AE-ish-companion-diagnostics-cdx">Companion Diagnostics</a></li></ul></div></div></div></div></li><li class="level0 technology col-1"> <a href="/image-contest" class="level0">Image Calendar</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Image Calendar</div> <span class="sectitle-span">+</span><ul><li><a href="/image-contest">Image Contest</a></li><li><a href="/data-image-gallery">Data Image Gallery</a></li></ul></div></div></div></div></li></ul></div><div class="col-lg-1 col-md-1 col-sm-1 col-xs-12 header-search search__button "><div class="search-icon">Search</div><div class="clear"></div></div></div></div> </header></div><div class="page-main-container"><div class="banner-container light"><div><img class="img-banner stick" src="/sites/default/files/DxWebPage.jpg"></div><h1 style="display: block;">RNAscope Technology for Diagnostics</h1></div><div class="content-container container custom-container science leadership"><div class="region region-content"><div id="block-system-main" class="block block-system clearfix"><div class="content"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs" id="myTab"><li class=" active"><a href="/diagnostics">Diagnostics</a></li><li class=""><a href="/diagnostics-literature">Literature</a></li><li class=""><a href="/node/465356">Diagnostics ASR Probes</a></li><li class=""><a href="/rnascope-ish-probe-high-risk-hpv-head-neck-cancer">Diagnostics CE-IVD Probes</a></li><li class=""><a href="/rnascope-ce-ivd-detection">Diagnostics CE-IVD Detection</a></li><li class=""><a href="/companion-diagnostics">Companion Diagnostics</a></li></ul></div><div id="node-71214" class="" about="/diagnostics" typeof="sioc:Item foaf:Document"><div class="abt-science-content diagnostic-content"><div class="abt-science-title">RNAscope Technology for Diagnostics</div><div class="content-body"><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p>Advanced Cell Diagnostics (ACD), inventors of the innovative RNAscope <em>in situ hybridization</em> (ISH) Technology have over 30,000+ RNA probes, designed and ready to use, available for most research areas and applications. RNAscope ISH technology with its proprietary double Z probe design and reagents enable reliable detection of RNA biomarkers at a single molecule sensitivity within morphological context for FFPE tissues. With 40+ issued and pending patents, over 4000 publications and customers in many diagnostic, pharma and academic fields, RNAscope technology is primed for adoption by the clinical and companion diagnostic community.</p><h3>RNAscope ISH for Diagnostics</h3><p>ACD has partnered with <a href="http://www.leicabiosystems.com/ACD" target="_blank">Leica Biosystems</a> to develop the fully automated <a href="/science/how-it-works">RNAscope ISH technology</a>, available for diagnostic use. The <a href="/science/how-it-works">RNAscope ISH Technology</a> has been optimized for diagnostic and clinical use on the BOND III Advanced Staining Clinical Platform. Please contact Leica Biosystems for more supporting information.</p><p>There are currently 16 ASR probes available: targeted for Albumin, CMV, EBV, HPV-6, HPV-11 (concentrate), HPV-16, HPV-18 (concentrate), HPV-31, HPV-31 (concentrate), HPV-33 (concentrate), Napsin-A, SARS-CoV-2, and TTF-1 covering a number of clinical disease states, as well as control probes: PPIB (Positive), UBC (Positive), and dapB (negative).</p><div class="posters-brochures"><div class="row immuno-watch"><h3>Ordering Information</h3><div class="col-md-12"><div class="classification full"><table class="table"><thead><tr><th><p>Product Code</p></th><th><p>Product Name</p></th><th><p>Size</p></th><th><p>Status</p></th><th><p>Order</p></th></tr></thead><tbody><tr class="odd"><td class="grey-bg" colspan="5"><p>Detection Kits</p></td></tr><tr class="even"><td><p>DS9790</p></td><td><p>BOND RNAscope Detection Reagents - BROWN</p></td><td><p>Pre-filled BOND containers</p></td><td><p>GPR</p></td><td><p><a href="https://shop.leicabiosystems.com/us/ihc-ish/detection-systems/pid-bond-rnascope-detection-reagents-brown" target="_blank">Order via Leica</a></p></td></tr><tr class="odd"><td><p>AR9773</p></td><td><p>BOND RNAscope Protease</p></td><td><p>Pre-filled BOND container</p></td><td><p>GPR</p></td><td><p><a href="https://shop.leicabiosystems.com/us/ihc-ish/detection-systems/pid-bond-rnascope-protease" target="_blank">Order via Leica</a></p></td></tr><tr class="odd"><td class="grey-bg" colspan="5"><p>Target probes</p></td></tr><tr><td><p>200440</p></td><td><p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; direction: ltr; unicode-bidi: embed; vertical-align: middle; word-break: normal;">RNAscope ISH Probe SARS-CoV-2</p></td><td>14 mL</td><td>ASR</td><td><p><a href="https://acdbio.com/store/rnascope-ish-probe-sars-cov-2.html" style="background-color: #0066d5;">Order via ACD</a></p></td></tr><tr class="even"><td><p>RS7750</p></td><td><p>ACD RNA ISH Probe CMV</p></td><td><p>14 mL</p></td><td><p>ASR</p></td><td><p><a href="http://www.leicabiosystems.com/ihc-ish-fish/acd-ish-probes/products/cmv-probe-1/" target="_blank">Order via Leica</a></p></td></tr><tr class="odd"><td><p>RS7751</p></td><td><p>ACD RNA ISH Probe EBV</p></td><td><p>14 mL</p></td><td><p>ASR</p></td><td><p><a href="http://www.leicabiosystems.com/ihc-ish-fish/acd-ish-probes/products/ebv-probe/" target="_blank">Order via Leica</a></p></td></tr><tr class="even"><td><p>RS7752</p></td><td><p>ACD RNA ISH Probe Albumin</p></td><td><p>14 mL</p></td><td><p>ASR</p></td><td><p><a href="http://www.leicabiosystems.com/ihc-ish-fish/acd-ish-probes/products/albumin-probe/" target="_blank">Order via Leica</a></p></td></tr><tr class="odd"><td><p>RS7753</p></td><td><p>ACD RNA ISH Probe TTF1</p></td><td><p>14 mL</p></td><td><p>ASR</p></td><td><p><a href="http://www.leicabiosystems.com/ihc-ish-fish/acd-ish-probes/products/ttf-1-probe/" target="_blank">Order via Leica</a></p></td></tr><tr class="even"><td><p>RS7754</p></td><td><p>ACD RNA ISH Probe Napsin A</p></td><td><p>14 mL</p></td><td><p>ASR</p></td><td><p><a href="http://www.leicabiosystems.com/ihc-ish-fish/acd-ish-probes/products/napsin-a-probe/" target="_blank">Order via Leica</a></p></td></tr><tr><td><p>RS7757</p></td><td><p>ACD RNA ISH Probe HPV-6</p></td><td>14 mL</td><td>ASR</td><td><p><a href="https://shop.leicabiosystems.com/us/ihc-ish/ish-probes-molecular-pathology/pid-acd-rna-ish-probe-hpv-6" target="_blank">Order via Leica</a></p></td></tr><tr><td><p>RS7758</p></td><td><p>ACD RNA ISH Probe HPV-16</p></td><td>14 mL</td><td>ASR</td><td><p><a href="https://shop.leicabiosystems.com/us/ihc-ish/ish-probes-molecular-pathology/pid-acd-rna-ish-probe-hpv-16" target="_blank">Order via Leica</a></p></td></tr><tr><td><p>RS7759</p></td><td><p>ACD RNA ISH Probe HPV-31</p></td><td>14 mL</td><td>ASR</td><td><p><a href="https://shop.leicabiosystems.com/us/ihc-ish/ish-probes-molecular-pathology/pid-acd-rna-ish-probe-hpv-31" target="_blank">Order via Leica</a></p></td></tr><tr><td><p>RS7860</p></td><td><p>ACD RNA ISH Probe (concentrate) HPV-11</p></td><td>80 µl</td><td>ASR</td><td><p><a href="https://shop.leicabiosystems.com/us/ihc-ish/ish-probes-molecular-pathology/pid-acd-rna-probe-hpv-11-concentrate" target="_blank">Order via Leica</a></p></td></tr><tr><td><p>RS7861</p></td><td><p>ACD RNA ISH Probe (concentrate) HPV-18</p></td><td>80 µl</td><td>ASR</td><td><p><a href="https://shop.leicabiosystems.com/us/ihc-ish/ish-probes-molecular-pathology/pid-acd-rna-probe-hpv-18-concentrate" target="_blank">Order via Leica</a></p></td></tr><tr><td><p>RS7862</p></td><td><p>ACD RNA ISH Probe (concentrate) HPV-31</p></td><td>80 µl</td><td>ASR</td><td><p><a href="https://shop.leicabiosystems.com/us/ihc-ish/ish-probes-molecular-pathology/pid-acd-rna-probe-hpv-31-concentrate" target="_blank">Order via Leica</a></p></td></tr><tr><td><p>RS7863</p></td><td><p>ACD RNA ISH Probe (concentrate) HPV-33</p></td><td><p>80 µl</p></td><td>ASR</td><td><p><a href="https://shop.leicabiosystems.com/us/ihc-ish/ish-probes-molecular-pathology/pid-acd-rna-probe-hpv-33-concentrate" target="_blank">Order via Leica</a></p></td></tr><tr class="odd"><td class="grey-bg" colspan="5"><p>ISH Control Probes</p></td></tr><tr class="even"><td><p>RS7755</p></td><td><p>PPIB (Positive Control)</p></td><td><p>14 mL</p></td><td><p>ASR</p></td><td><p><a href="http://www.leicabiosystems.com/ihc-ish-fish/acd-ish-probes/products/ppib-positive-control/" target="_blank">Order via Leica</a></p></td></tr><tr class="odd"><td><p>RS7756</p></td><td><p>dapB (Negative Control)</p></td><td><p>14 mL</p></td><td><p>ASR</p></td><td><p><a href="http://www.leicabiosystems.com/ihc-ish-fish/acd-ish-probes/products/dapb-negative-control/" target="_blank">Order via Leica</a></p></td></tr><tr><td><p>RS7760</p></td><td><p>ACD RNA ISH Probe UBC (Pos. Ctrl.)</p></td><td>14 mL</td><td>ASR</td><td><p><a href="https://shop.leicabiosystems.com/us/ihc-ish/ish-probes-molecular-pathology/pid-acd-rna-ish-probe-ubc-pos-ctrl" target="_blank">Order via Leica</a></p></td></tr></tbody></table></div><p><span style="color: rgb(34, 34, 34); font-family: Calibri, sans-serif; font-size: 14.6667px;">Additional information is available via </span> <a href="https://www.leicabiosystems.com/search/?q=acd" target="_blank">Leica Biosystems</a> .<span style="color: rgb(34, 34, 34); font-family: Calibri, sans-serif; font-size: 14.6667px;">To learn more, please find the informational materials below:</span></p></div></div><div class="row immuno-watch"><h3>Brochure</h3><div class="col-md-6"><a href="https://acdbio.com/system/files_force/Brochure-Leica-and-ACD.pdf?download=1"><img src="https://acdbio.com/sites/default/files/Brochure-Leica-and-ACD.jpg" /> </a></div><div class="col-md-6 content"><p>Leica Bond III ISH and IHC stainer and ACD's RNAscope</p><p><a class="immu-watch-link" href="/diagnostics-literature">View</a></p></div></div><div class="row immuno-watch"><h3>Flyer</h3><div class="col-md-6" style="text-align: center;"><a href="https://acdbio.com/system/files_force/Flyer-ACD-ISH.pdf?download=1"><img src="https://acdbio.com/sites/default/files/Flyer-ACD-ISH.jpg" /> </a><p>Leica Bond III and ACD RNAscope ISH Chromogenic Probes</p><p><a class="immu-watch-link" href="/diagnostics-literature">View</a></p></div><div class="col-md-6" style="text-align: center;"><a href="https://acdbio.com/system/files_force/MK51_186RevA_RNAscope_Anatomic_Pathology_Panels.pdf?download=1"><img src="https://acdbio.com/sites/default/files/MK51_186RevA_RNAscope_Anatomic_Pathology_Panels.jpg" /> </a><p>RNAscope™ Anatomic Pathology Panels</p><p><a class="immu-watch-link" href="https://acdbio.com/system/files_force/MK51_186RevA_RNAscope_Anatomic_Pathology_Panels.pdf?download=1">Download Flyer</a></p></div></div><div class="row immuno-watch"><h3> </h3></div><div class="row immuno-watch"> </div><h3>Partnership with Leica Biosystems</h3><div class="row immuno-watch"><div class="col-md-6"><p>Take a look at our short video, describing our partnership and continued progress to advance clinical diagnostics via innovative technologies including RNA ISH.</p><p><a class="immu-watch-link video-link" href="https://www.youtube.com/embed/FV_-FmKsRlY">Watch video</a></p></div><div class="col-md-6"><a class="video-link" href="https://www.youtube.com/embed/FV_-FmKsRlY"><img src="https://acdbio.com/sites/default/files/thumbnail.png" style="max-width: 100%;" /> </a></div></div><p>The ACD ASR Chromogenic ISH probes have been developed in partnership by both ACD and Leica Biosystems to be a fully-automated, plug and play RNA ISH that fits seamlessly with existing clinical laboratory equipment and workflows. The clinically proven standard protocol on the Bond III provides superior accuracy, reproducibility and reliability. The established chromogenic detection allows for standard bright-field review and analysis as preferred by pathologists, accustomed to reviewing IHC.</p><div class="row immuno-watch"><div class="col-md-12 contact-link text-center"><a href="http://www.leicabiosystems.com/ihc-ish-fish/bond-ancillary-ihc-ish-reagents/products/bond-rnascope-detection-reagents-brown/" target="_blank">Contact Leica</a></div><div class="col-md-12 contact-link text-center"> </div><div class="col-md-12 contact-link text-center"><a href="https://www.bio-techne.com/diagnostics/controls-reagents/rnascope-ish-probe-high-risk-hpv" target="_blank">Contact Clinical Sales</a></div><div class="col-md-12 contact-link text-center"> </div></div></div></div></div></div></div><div class="abt-science-sub"></div></div></div><div class="video-popup-show" id="video-popup-show"> <a class="video-popup-close"> <img class="video-popup-show_close" src="/sites/all/themes/acd/images/lightbox-close-btn.jpg" class="img"> </a><iframe 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action="https://proteinsimple--obtfull.my.salesforce.com/servlet/servlet.WebToCase?encoding=UTF-8" id="web-to-case1" method="POST"><div class="row"><div class="col-md-6"> <label for="fname">First Name</label> <input id="fname" maxlength="80" name="fname" size="20" type="text"></div><div class="col-md-6"> <label for="lname">Last Name</label> <input id="lname" maxlength="80" name="lname" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="email">Email</label> <input id="email" maxlength="80" name="email" size="20" type="text"></div><div class="col-md-6"> <label for="phone">Phone</label> <input id="phone" maxlength="40" name="phone" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="company">Institution / Company</label> <input id="company" maxlength="80" name="company" size="20" type="text"></div></div><div class="row"><div class="col-md-12"> <label for="description">Message</label> <textarea name="description"></textarea> </div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <label>Type the characters that you see in the picture below</label> <input type="text" id="PageCaseCaptcha" disabled /> <a class="btnrefresh" onclick="DrawCaptcha();"></a></div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <input type="text" class="case_captcha" id="PageCaseInput" name="case_captcha"/><div id="pagecasecaptcha-error"></div></div></div> <input type="submit" name="submit" style="float:left;" onclick="ValidCaptcha('pagecase');"><div class="clear"></div></form></div></div><div class="needhelp-tab-container tab-pane fade" id="contactinfo"><div class="supportform-con contact-info"><div class="row"><h3>Advanced Cell Diagnostics</h3><p>Our new headquarters office starting May 2016:</p><p>7707 Gateway Blvd. <br />Newark, CA 94560<br />Toll Free: 1 (877) 576-3636<br />Phone: (510) 576-8800<br />Fax: (510) 576-8798</p></div><div class="row"><p> </p><div class="row"><h3>Bio-Techne</h3><p>19 Barton Lane <br />Abingdon Science Park<br />Abingdon<br />OX14 3NB<br />United Kingdom<br />Phone 2: +44 1235 529449<br />Fax: +44 1235 533420</p><p> </p></div><div class="row"><h3>Advanced Cell Diagnostics China</h3><p>20F, Tower 3,<br />Raffles City Changning Office,<br />1193 Changning Road, Shanghai 200051</p><p>021-52293200<br /><a href="mailto:info.cn@bio-techne.com">info.cn@bio-techne.com</a><br />Web: <a href="http://www.acdbio.com/cn">www.acdbio.com/cn</a></p></div><div class="row"><p>For general information: <a href="mailto:Info.ACD@bio-techne.com">Info.ACD@bio-techne.com</a><br />For place an order: <a href="mailto:order.ACD@bio-techne.com">order.ACD@bio-techne.com</a><br />For product support: <a href="mailto:support.ACD@bio-techne.com">support.ACD@bio-techne.com</a><br />For career opportunities: <a href="mailto:hr.ACD@bio-techne.com">hr.ACD@bio-techne.com</a></p></div></div><div class="row" style="border-bottom: none;"><div class="col-md-6"> <a href="/about/distributors" class="meet-out-sales-team" title="See Distributors">See Distributors</a></div></div></div></div><div class="needhelp-tab-container tab-pane fade" id="contactpharma"><div class="supportform-con"><div class="contact-tab-form supportform-con"><form id="mktoForm_9817"></form> <script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9817);</script> </div></div></div></div></div></div></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { $("#web-to-case1").validate({ // Specify the validation rules rules: { fname: "required", lname: "required", phone:"required", email: { required: true, email: true }, company: "required", case_captcha: "required" }, // Specify the validation error messages messages: { fname: "Please enter your First Name", lname: "Please enter your Last Name", email: "Please enter your email address", phone: "Please enter your 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