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gene-1 (MDR-1) and Bcl-2 proteins. Thus, it is desirable to search for an alternative strategy for effective eradication of this type of cancer cells. We present evidence here for the first time that 6-shogaol (6-SG), an alkanone isolated from the rhizomes of ginger, can effectively induce apoptotic cell death of Mahlavu cells via an oxidative stress-mediated caspasedependent mechanism. The cascade of events in 6-SG-induced apoptosis of these cells involved an initial overproduction of reactive oxygen species (ROS) followed by a severe depletion of intracellular glutathione (GSH) contents. Both events consequently entailed a significant drop in mitochondrial transmembrane potential (∆Ψ m ), which ultimately activated the activities of caspases 3/7 resulting in the DNA fragmentation. Interestingly, we also found that N-acetylcysteine (NAC), an antioxidant and a precursor of GSH biosynthesis, could offer a near complete protection of apoptotic cell death exerted by 6-SG. Similarly, exogenously added GSH could also provide protection with an equal efficacy. However, it was paradoxical that both Boc-Asp(OMe)-fmk (a broad caspases inhibitor) and cyclosporin A (an mitochondrial permeability transition opening inhibitor) could only partially protect these cells from 6-SG-induced apoptosis. Taking these data into consideration, it is obvious that GSH depletion is the major contributing factor in arbitrating 6-SG-induced apoptosis of Mahlavu cells. In conclusion, we provide here a novel modality that can help to eradicate a p53 mutant of human hepatoma cells by using a natural consistent isolated form of ginger. These data also provide evidence to reaffirm the notion that consumption of certain foodstuffs can be beneficial to health because some of the constituents contained in them may be anticarcinogenic.","publication_date":"2007,,","publication_name":"Journal of Agricultural and Food Chemistry","grobid_abstract_attachment_id":"40254353"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"6-Shogaol (Alkanone from Ginger) Induces Apoptotic Cell Death of Human Hepatoma p53 Mutant Mahlavu Subline via an Oxidative Stress-Mediated Caspase-Dependent Mechanism","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [38866144]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript 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ds2-5-body-sm ds2-5-body-link" data-author-id="36617622" href="https://lu.academia.edu/saishyamnarayanan">sai shyam narayanan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PLoS ONE</p><p class="ds-related-work--abstract ds2-5-body-sm">We report mechanism-based evidence for the anticancer and chemopreventive efficacy of [6]-gingerol, the major active principle of the medicinal plant, Ginger (Zingiber officinale), in colon cancer cells. The compound was evaluated in two human colon cancer cell lines for its cytotoxic effect and the most sensitive cell line, SW-480, was selected for the mechanistic evaluation of its anticancer and chemopreventive efficacy. The non-toxic nature of [6]-gingerol was confirmed by viability assays on rapidly dividing normal mouse colon cells. [6]-gingerol inhibited cell proliferation and induced apoptosis as evidenced by externalization of phosphatidyl serine in SW-480, while the normal colon cells were unaffected. Sensitivity to [6]-gingerol in SW-480 cells was associated with activation of caspases 8, 9, 3 &7 and cleavage of PARP, which attests induction of apoptotic cell death. Mechanistically, [6]-gingerol down-regulated Phorbol Myristate Acetate (PMA) induced phosphorylation of ERK1...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"[6]-Gingerol Induces Caspase-Dependent Apoptosis and Prevents PMA-Induced Proliferation in Colon Cancer Cells by Inhibiting MAPK/AP-1 Signaling","attachmentId":77656405,"attachmentType":"pdf","work_url":"https://www.academia.edu/66481549/_6_Gingerol_Induces_Caspase_Dependent_Apoptosis_and_Prevents_PMA_Induced_Proliferation_in_Colon_Cancer_Cells_by_Inhibiting_MAPK_AP_1_Signaling","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/66481549/_6_Gingerol_Induces_Caspase_Dependent_Apoptosis_and_Prevents_PMA_Induced_Proliferation_in_Colon_Cancer_Cells_by_Inhibiting_MAPK_AP_1_Signaling"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="115253648" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/115253648/Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway">Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="29829624" href="https://mohp.academia.edu/AlaaeldinHamza">Alaaeldin A Hamza</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biomedicine &amp; Pharmacotherapy, 2021</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway","attachmentId":111714966,"attachmentType":"pdf","work_url":"https://www.academia.edu/115253648/Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/115253648/Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="46497810" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/46497810/NC_ND_license_Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway">NC-ND license Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="29829624" href="https://mohp.academia.edu/AlaaeldinHamza">Alaaeldin A Hamza</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Elsevier Masson SAS, 2021</p><p class="ds-related-work--abstract ds2-5-body-sm">Ginger has been proposed as quite a promising candidate for cancer prevention. The purpose of this study was to assess the chemo-preventive effects of ginger. Furthermore, this study investigated the possible mechanisms of a standardized extract drawn from the rhizomes of ginger against diethylnitrosamine (DEN)-induced liver cancer in Wistar rats. The chemo-preventive effects of ginger at doses of 75 mg/kg, 150 mg/kg and 300 mg/kg per day were determined using a liver cancer model which was induced by DEN (Ali et al., 2008) and 2-acetylaminofluor-ene (2-AAF) in rats. Ginger attenuated carcinogenic changes after 22 weeks of cancer induction by decreasing the quantity and occurrences of hepatic dyschromatic nodules and positive focal areas as well as decreasing the amount of placental glutathione S-transferase (GST) in the livers of DEN/2-AAF-treated rats. Moreover, in rats, ginger counteracts DEN-influenced oxidative stress and decreases myeloperoxidase, malondialdehyde and protein carbonyl concentrations in the liver. This was determined by observing the restoration of superoxide dis-mutase, catalase, GST and glutathione. Immunohistochemical bleaching in rat livers showed that ginger prevented the increase in cell-positive numbers for Ki-67, cyclooxygenase-2 and nuclear factor kappa B p65. Ginger also inhibited the number of positive cells in DEN/2-AAF-treated rats for TUNEL, M30 and caspase-3 liver tissues. This research shows that ginger has an important chemo-preventative impact on liver cancer by inhibiting the growth of cells and inducing apoptosis. By reducing oxidative and inflammatory damage, ginger protects rat liver against cancer.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"NC-ND license Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway","attachmentId":66228604,"attachmentType":"pdf","work_url":"https://www.academia.edu/46497810/NC_ND_license_Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/46497810/NC_ND_license_Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="4085611" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4085611/Induction_of_apoptosis_by_6_gingerol_associated_with_the_modulation_of_p53_and_involvement_of_mitochondrial_signaling_pathway_in_B_a_P_induced_mouse_skin_tumorigenesis">Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4926261" href="https://independent.academia.edu/MadhulikaSingh1">Madhulika Singh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer Chemotherapy and Pharmacology, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Purpose To unravel the molecular mechanisms underlying the chemopreventive potential of [6]-gingerol, a pungent ingredient of ginger rhizome (Zingiber officinale Roscoe, Zingiberaceae), against benzo[a]pyrene (B[a]P)-induced mouse skin tumorigenesis. Methods Topical treatment of [6]-gingerol (2.5 μM/animal) was given to the animals 30 min prior and post to B[a]P (5 μg/animal) for 32 weeks. At the end of the study period, the skin tumors/tissues were dissected out and examined histopathologically. Flow cytometry was employed for cell cycle analysis. Further immunohistochemical localization of p53 and regulation of related apoptogenic proteins were determined by Western blotting. Results Chemopreventive properties of [6]-gingerol were reflected by delay in onset of tumorigenesis, reduced cumulative number of tumors, and reduction in tumor volume. Cell cycle analysis revealed that the appearance of sub-G1 peak was significantly elevated in [6]-gingerol treated animals with post treatment showing higher efficacy in preventing tumorigenesis induced by B[a]P. Moreover, elevated apoptotic propensity was observed in tumor tissues than the corresponding non-tumor tissues. Western blot analysis also showed the same pattern of chemoprevention with [6]-gingerol treatment increasing the B[a]P suppressed p53 levels, also evident by immunohistochemistry, and Bax while decreasing the expression of Bcl-2 and Survivin. Further, [6]-gingerol treatment resulted in release of Cytochrome c, Caspases activation, increase in apoptotic protease-activating factor-1 (Apaf-1) as mechanism of apoptosis induction. Conclusions On the basis of the results we conclude that [6]-gingerol possesses apoptotic potential in mouse skin tumors as mechanism of chemoprevention hence deserves further investigation.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis","attachmentId":50042371,"attachmentType":"pdf","work_url":"https://www.academia.edu/4085611/Induction_of_apoptosis_by_6_gingerol_associated_with_the_modulation_of_p53_and_involvement_of_mitochondrial_signaling_pathway_in_B_a_P_induced_mouse_skin_tumorigenesis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/4085611/Induction_of_apoptosis_by_6_gingerol_associated_with_the_modulation_of_p53_and_involvement_of_mitochondrial_signaling_pathway_in_B_a_P_induced_mouse_skin_tumorigenesis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="68918427" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/68918427/Active_Compounds_from_Ginger_as_Inducers_of_Mitochondrial_Apoptotic_Pathway_An_in_Silico_Prediction">Active Compounds from Ginger as Inducers of Mitochondrial Apoptotic Pathway : An in Silico Prediction</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5682052" href="https://wbsubregistration.academia.edu/AshutoshMukherjee">Ashutosh Mukherjee</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2011</p><p class="ds-related-work--abstract ds2-5-body-sm">Knowledge about the mitochondrial apoptotic pathway is very important for chemotherapeutic drug development. The enzyme NADH dehydrogenase can be an important target for natural drugs in this respect. Active compounds of ginger (Zingiber officinale Roscoe) namely gingerol, paradol, shogaol and zingerone were selected as ginger is known to have anti-cancer properties. A three-dimensional model of the human NADH dehydrogenase was developed in silico and docked with gingerol, paradol, shogaol and zingerone. All of them were successfully docked. Among them, two compounds, namely 6-gingerol and 10-gingerol, formed covalent bonds with the enzyme showing that they are the most potent for drug development among the active components of ginger. The successful docking of these natural compounds with the enzyme showed that these compounds are potential inducers of the apoptotic pathway and thus important in chemotherapeutic drug development. ____________________________________________________...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Active Compounds from Ginger as Inducers of Mitochondrial Apoptotic Pathway : An in Silico Prediction","attachmentId":79219530,"attachmentType":"pdf","work_url":"https://www.academia.edu/68918427/Active_Compounds_from_Ginger_as_Inducers_of_Mitochondrial_Apoptotic_Pathway_An_in_Silico_Prediction","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/68918427/Active_Compounds_from_Ginger_as_Inducers_of_Mitochondrial_Apoptotic_Pathway_An_in_Silico_Prediction"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="63230378" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63230378/Herbal_Formulation_C168_Attenuates_Proliferation_and_Induces_Apoptosis_in_HCT_116_Human_Colorectal_Carcinoma_Cells_Role_of_Oxidative_Stress_and_DNA_Damage">Herbal Formulation C168 Attenuates Proliferation and Induces Apoptosis in HCT 116 Human Colorectal Carcinoma Cells: Role of Oxidative Stress and DNA Damage</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36786951" href="https://ukm-my.academia.edu/AsmahHamid">Asmah Hamid</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Evidence-Based Complementary and Alternative Medicine, 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">The use of herbal formulations has gained scientific interest, particularly in cancer treatment. In this study, the herbal formulation of interest, denoted as C168, is a mixture of eight genera of plants. This study aims to investigate the antiproliferative effect of C168 methanol extract (CME) on various cancer cells and its underlying mechanism of action on the most responsive cell line, namely, HCT 116 cells. CME exerted antiproliferative activities on HCT 116 colorectal carcinoma cells and HepG2 hepatocellular carcinoma cells but not on CCD-841-CoN normal colon epithelial cells, Jurkat E6.1 lymphoblastic leukemic cells, and V79-4 Chinese hamster lung fibroblasts. Further investigation on HCT 116 cells showed that CME induced G2/M cell-cycle arrest and apoptosis. Treatment of CME induced oxidative stress in HCT 116 cells by increasing the superoxide anion level and decreasing the intracellular glutathione. CME also increased tail moment value and H2AX phosphorylation in HCT 116 c...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Herbal Formulation C168 Attenuates Proliferation and Induces Apoptosis in HCT 116 Human Colorectal Carcinoma Cells: Role of Oxidative Stress and DNA Damage","attachmentId":75725344,"attachmentType":"pdf","work_url":"https://www.academia.edu/63230378/Herbal_Formulation_C168_Attenuates_Proliferation_and_Induces_Apoptosis_in_HCT_116_Human_Colorectal_Carcinoma_Cells_Role_of_Oxidative_Stress_and_DNA_Damage","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/63230378/Herbal_Formulation_C168_Attenuates_Proliferation_and_Induces_Apoptosis_in_HCT_116_Human_Colorectal_Carcinoma_Cells_Role_of_Oxidative_Stress_and_DNA_Damage"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":40254353,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":40254353,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_40254353" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="17017726" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17017726/6_Dehydrogingerdione_an_active_constituent_of_dietary_ginger_induces_cell_cycle_arrest_and_apoptosis_through_reactive_oxygen_species_c_Jun_N_terminal_kinase_pathways_in_human_breast_cancer_cells">6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36562658" href="https://independent.academia.edu/ChihhsingHung">Chih-hsing Hung</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecular Nutrition & Food Research, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells","attachmentId":42356905,"attachmentType":"pdf","work_url":"https://www.academia.edu/17017726/6_Dehydrogingerdione_an_active_constituent_of_dietary_ginger_induces_cell_cycle_arrest_and_apoptosis_through_reactive_oxygen_species_c_Jun_N_terminal_kinase_pathways_in_human_breast_cancer_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/17017726/6_Dehydrogingerdione_an_active_constituent_of_dietary_ginger_induces_cell_cycle_arrest_and_apoptosis_through_reactive_oxygen_species_c_Jun_N_terminal_kinase_pathways_in_human_breast_cancer_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="7035349" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/7035349/Molecular_targets_of_6_gingerol_Its_potential_roles_in_cancer_chemoprevention">Molecular targets of [6]-gingerol: Its potential roles in cancer chemoprevention</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="12005898" href="https://independent.academia.edu/AOYAGBEMI">ADEMOLA OYAGBEMI</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biofactors, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Molecular targets of [6]-gingerol: Its potential roles in cancer chemoprevention","attachmentId":48624970,"attachmentType":"pdf","work_url":"https://www.academia.edu/7035349/Molecular_targets_of_6_gingerol_Its_potential_roles_in_cancer_chemoprevention","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/7035349/Molecular_targets_of_6_gingerol_Its_potential_roles_in_cancer_chemoprevention"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="90418223" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90418223/Gingerol_sensitizes_TRAIL_induced_apoptotic_cell_death_of_glioblastoma_cells">Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="99887068" href="https://independent.academia.edu/DaeheeLee2">Dae-hee Lee</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Toxicology and applied pharmacology, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells","attachmentId":93987170,"attachmentType":"pdf","work_url":"https://www.academia.edu/90418223/Gingerol_sensitizes_TRAIL_induced_apoptotic_cell_death_of_glioblastoma_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/90418223/Gingerol_sensitizes_TRAIL_induced_apoptotic_cell_death_of_glioblastoma_cells"><span class="ds2-5-text-link__content">View 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