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href="../../Faculty/Adjunct_Professor.htm" title="Adjunct Professor">Adjunct Professor</a></dt> <dt><a href="../../Faculty/Postdoctor/Profile.htm" title="Postdoctor">Postdoctor</a></dt> <dt><a href="../../Faculty/Recruitment.htm" title="Recruitment">Recruitment</a></dt> </dl> </div> </section> <div class="clear"></div>  <div class="n_container n_b1 n_bg1"> <div class="wp flex"> <div class="nLeft"> <div class="n_t1"> <h3> Faculty</h3> <h4>Faculty</h4> </div> <div class="ejBox"> <ul class="list_ej"> <li><a href="../../Faculty/Outstanding_Talents.htm" title="Outstanding Talents" class="a"><span>Outstanding Talents</span></a></li> <li class="on"><a href="../../Faculty/Faculty_List1/Tenure_Track.htm" title="Faculty List" class="a"><span>Faculty List</span></a></li> <li><a href="../../Faculty/Adjunct_Professor.htm" title="Adjunct Professor" class="a"><span>Adjunct Professor</span></a></li> <li><a href="../../Faculty/Postdoctor/Profile.htm" title="Postdoctor" class="a"><span>Postdoctor</span></a></li> <li><a href="../../Faculty/Recruitment.htm" title="Recruitment" class="a"><span>Recruitment</span></a></li> </ul> </div> </div> <div class="nRight zzjs_d1"> <script language="javascript" src="../../_dwr/interface/NewsvoteDWR.js"></script><script language="javascript" src="../../_dwr/engine.js"></script><script language="javascript" src="/system/resource/js/news/newscontent.js"></script><script language="javascript" src="/system/resource/js/ajax.js"></script><form name="_newscontent_fromname"><script language="javascript" src="/system/resource/js/jquery/jquery-latest.min.js"></script> <div class="fl1 flex"> <div class="img slow imgBox"> <div class="imgLi" style=" background: url(/__local/E/4B/DE/9B3E3B24953583397DAE6926A6F_F89DC9DE_14786.jpg);"></div> </div> <div class="txt"> <h4>YU Jiakuo</h4> <div class="con"> <p class="l1 ps1">Professor</p> <p class="l1 ps1">Knee Surgery and Sports Medicine</p> <p class="l1 ps1">Beijing Tsinghua Changgung Hospital</p> <p class="l1 ps1">School of Clinical Medicine, Tsinghua University</p> <p class="l1 ps1"></p> </div> </div> </div> <div class="fl2"> <div class="box"> <h3 class="h3-1">Education and Employment</h3> <div class="ar_article"> <div class="v_news_content"> <p class="vsbcontent_start">2023. 11-Present Tenured Professor，School of Medicine, Tsinghua University</p> <p>2023. 11-Present Chief Physician，<strong>Orthopaedic and Sports Medicine Center, </strong>T<strong>singhua Changgung Hospital</strong>, Tsinghua University</p> <p>2010. 05-2023. 11 Level-2 Professor，Institute of Sports Medicine of Peking University, Peking University 3<sup>rd</sup> Hospital. Department of Sports Medicine, Peking University 3<sup>rd</sup> Hospital</p> <p>2007.08-2023.11 Chief Physician，Institute of Sports Medicine of Peking University, Peking University 3<sup>rd</sup> Hospital. Department of Sports Medicine, Peking University 3<sup>rd</sup> Hospital</p> <p>2006.08-2023.11 Research Scientist，Institute of Sports Medicine of Peking University，Peking University 3<sup>rd</sup> Hospital</p> <p>2002.08-2008.08 Level-3 Professor，Institute of Sports Medicine of Peking University, Peking University 3<sup>rd</sup> Hospital.</p> <p>2002.08-2007.08 Associate Chief Physician，Institute of Sports Medicine of Peking University, Peking University 3<sup>rd</sup> Hospital.</p> <p>1997.08- 2002.08 Associate Research Scientist，Attending Physician，Institute of Sports Medicine of Peking University，Peking University 3<sup>rd</sup> Hospital</p> <p>1993.08-1997.08 Assistant Research ，Resident Physician，Institute of Sports Medicine of Peking University，Peking University 3<sup>rd</sup> Hospital</p> <p>1990.08-1993.08 Ph.D., Institute of Sports Medicine of Peking University, Peking University 3<sup>rd</sup> Hospital.</p> <p>1987.08-1990.08 Master Degree，Department of Rehabilitation & Sports Medicine，The 1<sup>st</sup> Affiliated Hospital of Anhui Medical University</p> <p class="vsbcontent_end">1982.08-1987.08 B.S., Department of Medicine, Anhui Medical University</p> </div> </div> </div> <div class="box"> <h3 class="h3-1">Research Field</h3> <div class="ar_article"> <p class="vsbcontent_start">1. Research and development of stem cell drugs, tissue engineering scaffolds, tissue engineering cartilage, tissue engineered-meniscus, tissue engineered-ligaments and artificial ligaments, and tissue engineered-bone. Nanomaterials, functional small molecules, microenvironmental regulation, role of stem cells in tissue regeneration. Stem cells and regenerative medicine related molecular mechanisms, target molecules, bioinformatics analysis, multi-omics analysis, and single-cell sequencing research.</p> <p>2. Research on molecular subtypes, susceptibility genes, molecular mechanisms and therapeutic target molecules, stem cell therapy and stem cell delivery system therapy of OA.</p> <p>3. Studies on bionic anatomical reconstruction of anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL), allogeneic and xenogenic tissue transplantation reconstruction, brain regions activation related to cruciate ligament injury or/and reconstruction and return-to-sport after cruciate ligament injury or/and reconstruction, susceptibility genes and genetic diagnosis for cruciate ligament rupture.</p> <p>4. Research on repair and reconstruction of knee meniscus injury or/and surgery, total or partial meniscus transplantation of allogeneic and xenogeneic meniscus grafts, meniscus regeneration related to meniscus injury, and knee joint degeneration related to meniscus injury.</p> <p>5. Research on allogeneic and xenogeneic osteochondral transplantation reconstruction for knee osteochondral defects, intraoperative real-time patient-to-patient osteochondral transplantation reconstruction, autologous stem cell transplantation for articular cartilage repair, and intraoperative in situ 3D bioprinting for repair and reconstruction of cartilage injury.</p> <p>6. Clinical threshold studies for surgical indications of patellofemoral joint disorders, innovative surgical procedures researches, research on pedigree with patellar femoral disorder, study on susceptibility genes and its genetic diagnosis.</p> <p>7. Artificial intelligence-assisted diagnosis and treatment for bone and joint injuries, preoperative planning, surgical navigation, surgical robots, intraoperative and postoperative intelligent evaluation, and remote intelligent rehabilitation research.</p> <p class="vsbcontent_end">8. Research and clinical application of personalized diagnosis and treatment technology, personalized surgical technology, intraoperative personalized medical devices and related medical equipment for bone and joint injuries.</p> </div> </div> <div class="box"> <h3 class="h3-1">Selected Publications</h3> <div class="ar_article"> <p class="vsbcontent_start">1. Zhang ZZ#, Jiang D#, Wang SJ, Qi YS, Zhang JY, Yu JK *(通信作者). <a href="http://www.ncbi.nlm.nih.gov/pubmed/26102091">The potential of centrifugal seeding method in improving cells distribution and proliferation on the demineralized cancellous bone scaffolds for tissue engineered meniscus.</a> ACS Appl Mater Interfaces. 2015, 7(28): 15294-302 PMID: 26102091. Doi: 10.1021/acsami.5b03129.</p> <p>2. Zhang ZZ#, Jiang D#, Ding JX,* Wang SJ, Zhang L, Zhang JY, Qi YS, Chen XS, Yu JK*. Role of scaffold mean pore size in meniscus regeneration. Acta Biomater. 2016, 43: 314-326. Doi: 10.1016/j.actbio.2016.07.050. PubMed PMID: 27481291.</p> <p><a></a>3. Zheng-Zheng Zhang#, You-Rong Chen#, Shao-Jie Wang#, Feng Zhao#, Xiao-Gang Wang, Fei Yang, Jin-Jun Shi, Zi-Gang Ge, Wen-Yu Ding, Yu-Chen Yang, Tong-Qiang Zou, Ji-Ying Zhang, Jia-Kuo Yu,<a href="https://stm.sciencemag.org/content/11/487/eaao0750#corresp-1">*</a> and Dong Jiang<a href="https://stm.sciencemag.org/content/11/487/eaao0750#corresp-1">*</a>. Orchestrated biomechanical, structural, and biochemical stimuli for engineering anisotropic meniscus. Sci Transl Med. 2019，11（487）: eaao0750. DOI: 10.1126/scitranslmed.aao0750.</p> <p><a></a>4. Wang SJ#, Jiang D# , Zhang ZZ#, Chen YR, Yang ZD, Zhang JY, Shi J*(共同通讯作者), Wang X*, Yu JK*. <a href="https://www.ncbi.nlm.nih.gov/pubmed/31621958">Biomimetic Nanosilica-Collagen Scaffolds for In Situ Bone Regeneration: Toward a Cell-Free, One-Step Surgery.</a> Adv Mater. 2019, 31(49): e1904341. Doi: 10.1002/adma.201904341. Epub 2019 Oct 17. PMID: 31621958.</p> <p>5. Feifei Sun#, Yazhong Bu#, Yourong Chen, Fei Yang, Jiakuo Yu*, and Decheng Wu*. An Injectable and Instant Self-Healing Medical Adhesive for Wound Sealing. ACS APPLIED MATERIALS & INTERFACES 2020, 12(8):9132-9140. 20221129. Doi: 10.1021/acsami.0c01022.</p> <p><a></a>6. Yanyu Yang#, Yatian Yang#, Yanxia Cao, Xing Wang⁎, Yourong Chen, Hongyan Liu, Yafei Gao, Jianfeng Wang, Chao Liu, Wanjie Wang⁎, Jia-Kuo Yu⁎, Decheng Wu⁎ . Anti-freezing, resilient and tough hydrogels for sensitive and large-range strain and pressure sensors. Chemical Engineering Journal 2021，403:126431. Received 20 May 2020; Received in revised form 10 July 2020; Accepted 23 July 2020; Available online 27 July 2020. Doi: <a href="https://doi-org-443.webvpn.bjmu.edu.cn/10.1016/j.cej.2020.126431">10.1016/j.cej.2020.126431</a><b>（</b><b>ESI highly cited</b>）.</p> <p><a></a>7. Yan X#, Yang B#, Chen YR#, Song YF, Ye J, Pan YF, Zhou BN, Wang YQ, Mao FB, Dong YC, Liu DS*, Yu JK*. Anti-Friction MSCs Delivery system improves the therapy for severe osteoarthritis. Advanced materials. 2021 Oct 17; e2104758. Doi: 10.1002/adma.202104758.</p> <p><a></a>8. Fan BS#, Ye J#, Xu BB#, Sun ZW, Zhang JY, Song ST, Wang XJ, Song YF, Zhang ZZ*, Jiang D*, Yu JK*. Study on feasibility of the partial meniscal allograft transplantation. Clin Transl Med. 2022, 12(1): e701. Doi: 10.1002/ctm2.701. PMID: 35088938.</p> <p>9. Meng Yang#, Zheng-Chu Zhang#, Fu-ZhenYuan#, Rong-Hui Deng, XinYan, Feng-Biao Mao, You-Rong Chen*, Hua Lu*, Jia-KuoYu*. An immunomodulatory polypeptide hydrogel for osteochondral defect repair. Bioact Mater. 2022, 19: 678-689. (IF=18.9, Q1). (January 2021) . Doi: 10.1016/j.bioactmat.2022.05.008<b>（</b><b>ESI highly cited</b>）.</p> <p>10. Bingbing Xu#, Jing Ye#, Bao-Shi Fan, Xinjie Wang, Ji-Ying Zhang, Shitang Song, Yifan Song, Wen-Bo Jian*, Xing Wang*, Jia-Kuo Yu*. Protein-spatiotemporal partition releasing gradient porous scaffolds and anti-inflammatory and antioxidant regulation remodel tissue engineered anisotropic meniscus. Bioact Mater. 2022, 20: 194-207. (January 2021) . doi: 10.1016/j.bioactmat.2022.05.019<b>（</b><b>ESI highly cited</b>）.</p> <p>11. Chen YR#, Yan X#, Yuan FZ#, Lin L, Wang SJ, Ye J, Zhang JY, Yang M, Wu DC*, Wang X*, Yu JK*. <a href="https://pubmed.ncbi.nlm.nih.gov/36253092/">Kartogenin-Conjugated Double-Network Hydrogel Combined with Stem Cell Transplantation and Tracing for Cartilage Repair.</a> Adv Sci (Weinh). 2022 Oct17:e2105571. Doi: 10.1002/advs.202105571. Online ahead of print.PMID: 36253092.</p> <p>12. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Liu+L&cauthor_id=37975685">Lei Liu</a>#, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Xian+Y&cauthor_id=37975685">Yiwen Xian</a>#, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Wang+W&cauthor_id=37975685">Wantao Wang</a> , <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Huang+L&cauthor_id=37975685">Lin Huang</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Fan+J&cauthor_id=37975685">Jinghao Fan</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Ma+W&cauthor_id=37975685">Wenzheng Ma</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Li+Y&cauthor_id=37975685">Yixi Li</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=37975685">Hongmei Liu</a>*, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Yu+JK&cauthor_id=37975685">Jia-Kuo Yu</a>*, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Wu+D&cauthor_id=37975685">Decheng Wu</a>*. Meniscus-Inspired Self-Lubricating and Friction-Responsive Hydrogels for Protecting Articular Cartilage and Improving Exercise. ACS Nano 2023 Dec 12;17(23): 24308-24319. doi: 10.1021/acsnano.3c10139. Epub 2023 Nov 17. （JCR，Q1，IF 17.1）.</p> <p>13. Chao Li#, Ronghui Deng#, Meng Yang, Fuzhen Yuan, Chong Zhang, and Jiakuo Yu*. Advanced Hydrogel Material for Meniscus Repair. Adv. Funct. Mater. 2024, 2312276. DOI: 10.1002/adfm.202312276.</p> <p><a></a>14. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Ye+J&cauthor_id=38009465">Jing Ye</a>#, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Deng+R&cauthor_id=38009465">Ronghui Deng</a>#, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Wang+X&cauthor_id=38009465">Xinjie Wang</a>#, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Song+S&cauthor_id=38009465">Shitang Song</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Xu+X&cauthor_id=38009465">Xiong Xu</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+JY&cauthor_id=38009465">Ji-Ying Zhang</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Xu+BB&cauthor_id=38009465">Bing-Bing Xu</a>*, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Wang+X&cauthor_id=38009465">Xing Wang</a>*, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Yu+JK&cauthor_id=38009465">Jia-Kuo Yu</a>*. Intra-articular Histone Deacetylase Inhibitor Microcarrier Delivery to Reduce Osteoarthritis. Nano Lett. 2023 Dec 13;23(23):10832-10840. Epub 2023 Nov 27. PMID: 38009465. PMCID: <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10722529/">PMC10722529</a>. DOI: <a href="https://doi.org/10.1021/acs.nanolett.3c03037">10.1021/acs.nanolett.3c03037</a>.</p> <p class="vsbcontent_end">15. <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con1">RONGHUI DENG</a>#, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con2">RUIFANG ZHAO</a>#, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con3">ZINING ZHANG</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con4">YANG CHEN</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con5">MENG YANG</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con6">YIXUAN LIN</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con7">JING YE</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con8">NAN LI</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con9">HAO QIN</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con10">XIN YAN</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con11">JIAN SHI</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con12">FUZHEN YUAN</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con13">SHITANG SONG</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con14">ZIJIE XU</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con15">YIFAN SONG</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con16">JIANGNAN FU</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con17">BINGBING XU</a>, <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con18">GUANGJUN NIE</a>* , AND <a href="https://www.science.org/doi/10.1126/scitranslmed.adh9751#con19">JIA-KUO YU</a>*. Chondrocyte membrane–coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis. SCIENCE TRANSLATIONAL MEDICINE, 21 Feb 2024, Vol 16, Issue 735, <a href="https://doi.org/10.1126/scitranslmed.adh9751">DOI: 10.1126/scitranslmed.adh9751</a>.</p> </div> </div> <div class="box"> <h3 class="h3-1">Awards and Membership</h3> <div class="ar_article"> <p class="vsbcontent_start">Founding Chairman of the Geriatric Sports Medicine Branch of the Chinese Society of Gerology and Geriatrics.</p> <p>Enjoys the Special Government Allowance of The State Council of the People’s Republic of China.</p> <p>Health Consultation Expert of CPC Central Committee</p> <p>Medical Expert of the National Team for Summer and Winter Olympic Games.</p> <p>Chief editor of Arthroscopy and Sports Medicine of the Fifth Editorial Board of Orthopedic Journal of China</p> <p>Associate Editor of Chinese Journal of Sports Medicine</p> <p>Executive Editor of Chinese Journal of Bone and Joint Surgery</p> <p>Editorial Board Members of several other Journals.</p> <p class="vsbcontent_end">Vice Presidents and Vice Chairmans of 7 Societies.</p> </div> </div> <div class="box"> <h3 class="h3-1">Contact Information</h3> <div class="ar_article"> <p class="vsbcontent_start">Email: yujiakuo@tsinghua.edu.cn<br></p> </div> </div> </div> </form> </div> </div> </div>   <footer> <div class="fl1"> <div class="wp flex"> <div class="left"> <div class="f_logo"> <img src="../../images/f_logo.png" alt="" class="w100"> </div> <ul class="ewm1 flex"> <li> <img src="../../images/ewm1.jpg"> <h6></h6> </li> </ul> <div class="list8"> <script language="javascript" src="/system/resource/js/news/mp4video.js"></script> <p class="p1"> Postcode: 100084    Email: lcyweb@tsinghua.edu.cn </p> <p class="p2"> Address: Tsinghua University, Haidian District, Beijing, China </p> </div> </div> <div class="right"> <ul class="f_nav flex"> <li> <a> <div class="h3">About Us</div> </a> <div class="sub"> <div class="box"> <a href="../../About_Us/Introduction.htm" title="Introduction">Introduction</a> <a href="../../About_Us/History.htm" 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