CINXE.COM
Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants | eLife
<!doctype html> <html lang="en" prefix="og: http://ogp.me/ns#"> <head> <meta charset="utf-8"> <title>Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants | eLife</title> <meta name="viewport" content="width=device-width,initial-scale=1,shrink-to-fit=no"> <meta name="format-detection" content="telephone=no"> <script id="Cookiebot" src="https://consent.cookiebot.com/uc.js" data-cbid="0a5c50d8-fcf9-47b1-8f4f-1eaadb13941b" type="text/javascript"></script> <script> document.querySelector('html').classList.add('js'); </script> <style> @font-face{font-display:fallback;font-family:"Noto Sans";src:url(/assets/patterns/fonts/NotoSans-Regular-webfont-custom-2-subsetting.6031b15b.woff2) format("woff2")}@font-face{font-display:fallback;font-family:"Noto Sans";src:url(/assets/patterns/fonts/NotoSans-SemiBold-webfont-custom-2-subsetting.8b9e80d5.woff2) format("woff2");font-weight:700}@font-face{font-display:fallback;font-family:"Noto Serif";src:url(/assets/patterns/fonts/NotoSerif-Regular-webfont-custom-2-subsetting.e6069232.woff2) format("woff2")}@font-face{font-display:fallback;font-family:"Noto Serif";src:url(/assets/patterns/fonts/NotoSerif-Bold-webfont-basic-latin-subsetting.592fd0d5.woff2) format("woff2");font-weight:700}html{font-family:sans-serif;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%}body{margin:0}aside,header,main,nav,section{display:block}picture{display:inline-block;vertical-align:baseline}a{background-color:transparent}b{font-weight:inherit}b{font-weight:bolder}h1{font-size:2em;margin:.67em 0}img{border:0}svg:not(:root){overflow:hidden}button,input{font:inherit;margin:0}button{overflow:visible}button{text-transform:none}button{-webkit-appearance:button}button::-moz-focus-inner,input::-moz-focus-inner{border:0;padding:0}button:-moz-focusring,input:-moz-focusring{outline:ButtonText dotted 1px}input{line-height:normal}input[type=checkbox]{box-sizing:border-box;padding:0}input[type=search]{-webkit-appearance:textfield}input[type=search]::-webkit-search-cancel-button,input[type=search]::-webkit-search-decoration{-webkit-appearance:none}fieldset{border:1px solid silver;margin:0 2px;padding:.35em .625em .75em}*,:after,:before{box-sizing:border-box}body,html{height:100%}body{background-color:#fff;color:#212121;text-rendering:optimizeLegibility}h1{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:700;font-size:2.25rem;line-height:1.33333;font-size:2.25rem;margin:0}h2{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:700;font-size:1.625rem;line-height:1.15385;margin:0;padding-bottom:21px;padding-bottom:1.3125rem;padding-top:21px;padding-top:1.3125rem}h6{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:700;font-size:1rem;line-height:1.5;margin:0;padding-top:10px;padding-top:.625rem;padding-bottom:14px;padding-bottom:.875rem}p{font-family:"Noto Serif",serif;font-size:1rem;line-height:1.5;font-weight:400;margin:0;margin-bottom:24px;margin-bottom:1.5rem}a{color:#087acc;text-decoration:none}b{font-weight:700}ol,ul{margin-bottom:24px;margin-bottom:1.5rem;margin-top:0;padding-left:48px;padding-left:3rem}dl{margin-bottom:24px;margin-bottom:1.5rem;margin-top:0}dd,dt,li{font-family:"Noto Serif",serif;font-size:1rem;line-height:1.5;font-weight:400}dt{font-weight:700}dd{margin-left:0}.hidden{display:none}.visuallyhidden{border:0;clip:rect(0 0 0 0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}.clearfix{zoom:1}.clearfix:after,.clearfix:before{content:"";display:table}.clearfix:after{clear:both}.global-inner:after{content:"";display:block;clear:both}img{max-height:100%;max-width:100%}input[type=checkbox]{margin-right:6px;margin-right:.375rem}::-webkit-input-placeholder{color:#bdbdbd}::-moz-placeholder{color:#bdbdbd}:-ms-input-placeholder{color:#bdbdbd}:-moz-placeholder{color:#bdbdbd}.grid-column{margin-bottom:48px;margin-bottom:3rem}@media only all and (min-width:45.625em){.grid-column{margin-bottom:72px;margin-bottom:4.5rem}}.grid-secondary-column__item{margin-bottom:48px;margin-bottom:3rem}@media only all and (min-width:45.625em){.grid-secondary-column__item{margin-bottom:72px;margin-bottom:4.5rem}}.wrapper{box-sizing:content-box;max-width:1114px;max-width:69.625rem;margin:auto;padding-left:24px;padding-right:24px}@media only screen and (min-width:30em){.wrapper{padding-left:48px;padding-right:48px}}.wrapper.wrapper--content{padding-top:48px;padding-top:3rem}.content-header-image-wrapper+.wrapper.wrapper--listing,.content-header-simple+.wrapper.wrapper--listing{padding-top:0}.grid{list-style:none;margin:0;padding:0;margin-left:-1.6%;margin-right:-1.6%;zoom:1}.grid:after,.grid:before{content:"";display:table}.grid:after{clear:both}.grid__item{float:left;padding-left:1.6%;padding-right:1.6%;width:100%;box-sizing:border-box}@media only screen and (min-width:900px){.large--eight-twelfths{min-height:1px;width:66.666%}.large--ten-twelfths{min-height:1px;width:83.333%}.push--large--one-twelfth{left:8.333%}}@media only screen and (min-width:1200px){.x-large--two-twelfths{min-height:1px;width:16.666%}.x-large--seven-twelfths{min-height:1px;width:58.333%}.x-large--eight-twelfths{min-height:1px;width:66.666%}.push--x-large--zero{left:0}.push--x-large--two-twelfths{left:16.666%}}.breadcrumbs{margin:0;margin:0;padding:0;padding:0}.breadcrumbs .breadcrumb-item{font-size:.875rem;line-height:1.71429;margin:0;margin:0;padding:0;padding:0;display:inline;font-family:"Noto Sans",Arial,Helvetica,sans-serif;list-style:none}.breadcrumbs .breadcrumb-item:after{content:" | "}.breadcrumbs .breadcrumb-item:last-child:after{content:""}.breadcrumbs .breadcrumb-item .breadcrumb-item__link{color:#212121}.button{border:none;border-radius:4px;color:#fff;display:inline-block;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.875rem;line-height:1;font-weight:500;padding:17px 40px 16px;padding:1.0625rem 2.5rem 1rem;text-align:center;text-decoration:none;text-transform:uppercase}.button--default{background-color:#087acc;border:1px solid #087acc;color:#fff;padding:15px 36px 14px;padding:.9375rem 2.25rem .875rem}.button--secondary{background-color:#f7f7f7;border:1px solid #e0e0e0;color:#212121;padding:15px 36px 14px;padding:.9375rem 2.25rem .875rem}.button--extra-small{border-radius:3px;font-size:.6875rem;line-height:2.1818181818;padding:0 6px;padding:0 .375rem;height:24px;height:1.5rem}.button--action{padding:9px 20px;padding:.5625rem 1.25rem;background-color:#edeff4;border:none;color:#212121;display:-ms-inline-flexbox;display:inline-flex;font-weight:700;min-height:40px;line-height:24px;text-transform:initial}.button--action.icon{padding-left:40px;padding-left:2.5rem;background-position:11px;background-repeat:no-repeat}.button--action.icon-comment{background-image:url(/assets/patterns/img/icons/commenting.1b2facba.svg)}.button--action.icon-citation{background-image:url(/assets/patterns/img/icons/cite.5f3c4fab.svg)}.button--action.icon-download{background-image:url(/assets/patterns/img/icons/download.ecfa2d98.svg)}.button--action.icon-share{background-image:url(/assets/patterns/img/icons/share.5cbd86ce.svg)}.date{font-size:.875rem;line-height:1.71429;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:400;color:inherit;font-size:.75rem;line-height:2}.definition-list--timeline dd,.definition-list--timeline dt{padding-left:28px;padding-left:1.75rem;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:700;position:relative}.definition-list--timeline dt{font-size:1rem;line-height:1.5;margin-top:18px;margin-top:1.125rem}.definition-list--timeline dt:first-child{margin-top:0;margin-top:0}.definition-list--timeline dd{font-size:.875rem;line-height:1.71429;color:#757575}.definition-list--timeline dd:before,.definition-list--timeline dt:before{background-color:#edeff4;content:"";height:100%;left:0;position:absolute;top:0;width:8px}.definition-list--timeline dt:before{border-radius:6px 6px 0 0}.definition-list--timeline dd:before{border-radius:0 0 6px 6px}.doi{font-size:.875rem;line-height:1.71429;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:400;color:#757575}.doi a.doi__link{border-bottom:none;color:#757575;text-decoration:none;text-transform:none}.doi--article-section{color:#212121;display:block;font-size:.875rem;margin-bottom:24px;margin-bottom:1.5rem}.doi--article-section a.doi__link{color:#212121}.form-item{margin-bottom:24px;margin-bottom:1.5rem}.form-item>:last-child{margin-bottom:0}@supports (display:flex){.form-item__label_container{display:-ms-flexbox;display:flex;-ms-flex-pack:justify;justify-content:space-between}}.form-item__label{display:block;color:#212121;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.875rem;line-height:1.42857;font-weight:700;text-align:left;margin-bottom:4px;margin-bottom:.25rem}.info-bar{background-color:#087acc;color:#fff;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.875rem;font-weight:600;padding:14px 8px;padding:.875rem .5rem;text-align:center}.info-bar__text{background-position:0 50%;background-repeat:no-repeat;display:inline-block;padding:2px 0 0 28px;padding:.125rem 0 0 1.75rem;font-size:.875rem;line-height:1.3}.info-bar--warning .info-bar__text{padding-left:0;padding-left:0}.info-bar--announcement{padding:0;padding:0;background-color:#f5f7fa;color:#212121}.info-bar--announcement a{color:#087acc;font-weight:600;text-decoration:none}.info-bar--announcement .info-bar__container{padding:28px;padding:1.75rem;margin-bottom:24px;margin-bottom:1.5rem}.info-bar--announcement .info-bar__text{padding-top:0;padding-top:0;background:url(/assets/patterns/img/icons/info-blue.857b9409.svg) no-repeat,linear-gradient(transparent,transparent);font-weight:400;line-height:1.7;text-align:left}.info-bar--info .info-bar__text{background-image:url(/assets/patterns/img/icons/info.96b39fb1.png);background-image:url(/assets/patterns/img/icons/info.6662c626.svg),linear-gradient(transparent,transparent)}.info-bar--multiple-versions{background-color:#087acc}.info-bar--multiple-versions .info-bar__text{background-image:url(/assets/patterns/img/icons/multiple-versions-article.336e926c.png);background-image:url(/assets/patterns/img/icons/multiple-versions-article.96fdc4b8.svg),linear-gradient(transparent,transparent);background-size:17px}.info-bar--success{background-color:#629f43}.info-bar--success .info-bar__text{background-image:url(/assets/patterns/img/icons/confirmed.79ce7ac4.png);background-image:url(/assets/patterns/img/icons/confirmed.c30e8709.svg),linear-gradient(transparent,transparent)}.info-bar--attention{background-color:#cf0c4e}.info-bar--attention .info-bar__text{background-image:url(/assets/patterns/img/icons/attention.de73644c.png);background-image:url(/assets/patterns/img/icons/attention.77e4036b.svg),linear-gradient(transparent,transparent)}.info-bar--correction{background-color:#cf0c4e}.info-bar--correction .info-bar__text{background-image:url(/assets/patterns/img/icons/corrected-article.7be00f7a.png);background-image:url(/assets/patterns/img/icons/corrected-article.9cd6ecfe.svg),linear-gradient(transparent,transparent);background-size:17px}.info-bar--dismissible{padding-top:24px;padding-top:1.5rem;box-sizing:content-box;max-width:1114px;max-width:69.625rem;margin:auto;padding-left:24px;padding-right:24px;background-color:inherit;max-width:1114px}@media only screen and (min-width:30em){.info-bar--dismissible{padding-left:48px;padding-right:48px}}@media only screen and (min-width:56.25em){.info-bar--dismissible:not(.hidden){display:-ms-grid;display:grid;-ms-grid-columns:(1fr)[12];grid-template-columns:repeat(12,1fr)}}.js .info-bar--dismissible:not([data-behaviour-initialised]){display:none}.info-bar--dismissible .info-bar__container{padding:14px 15px 9px;padding:.875rem .9375rem .5625rem;background-color:#f5f7fa;color:#212121;display:-ms-flexbox;display:flex;grid-column:2/12}@media only screen and (min-width:75em){.info-bar--dismissible .info-bar__container{grid-column:1/13}}.info-bar--dismissible .info-bar__text{font-size:.875rem;line-height:1.71429;padding:0 8px 0 30px;padding:0 .5rem 0 1.875rem;background:url(/assets/patterns/img/icons/info-blue.857b9409.svg) no-repeat,linear-gradient(transparent,transparent);background-size:24px;font-weight:400;text-align:left;width:100%}.info-bar--dismissible .info-bar__text a{padding-left:2px;padding-left:.125rem;color:#087acc;font-weight:600;text-decoration:none}.info-bar--dismissible .dismiss-button{padding:5px;padding:.3125rem;background:url(/assets/patterns/img/icons/close.f00467a1.svg) center no-repeat;border:0;border-radius:2px;display:inline-block;float:right;height:24px;text-indent:-10000px;width:24px}.info-bar--dismissible .dismiss-button:hover{background-color:rgba(0,0,0,.15)}.info-bar--warning{background-color:#d14600}.main-menu .list-heading{padding-left:0;padding-right:0;padding-top:24px;padding-top:1.5rem;padding-bottom:24px;padding-bottom:1.5rem;text-align:center}.js .main-menu .list-heading{border:0;clip:rect(0 0 0 0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}.media-source__fallback_link{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.875rem;text-decoration:none}.modal-container{background-color:rgba(255,255,255,.9);height:100%;left:0;position:fixed;top:0;width:100%;visibility:hidden}.modal-content{background-color:#fff;border-radius:3px;box-shadow:0 0 20px rgba(0,0,0,.22);display:-ms-grid;display:grid;font-family:"Noto Sans",Arial,Helvetica,sans-serif;margin:0;padding:36px}@media only all and (min-width:30em){.modal-content{margin:24px}}@media only all and (min-width:48.625em){.modal-content{margin:180px auto 24px;max-width:730px}}.modal-content h6{font-size:1rem;line-height:1.5;padding-bottom:6px;padding-bottom:.375rem;grid-column:1/3;-ms-grid-row:1;grid-row:1;justify-self:start;padding-top:0}.modal-content .social-media-sharers{margin-bottom:0;margin-bottom:0;display:-ms-flexbox;display:flex;grid-column:1/3;-ms-grid-row:4;grid-row:4;-ms-flex-pack:center;justify-content:center}@media only all and (min-width:45.625em){.modal-content .social-media-sharers{-ms-grid-row:unset;grid-row:unset;-ms-flex-pack:left;justify-content:left}.modal-content .social-media-sharers li{margin:0 4px;margin:0 .25rem}.modal-content .social-media-sharers li:first-child{margin-left:0;margin-left:0}.modal-content .social-media-sharers li:first-child a{margin-left:0;margin-left:0}}.modal-content .reference{font-family:"Noto Sans",Arial,Helvetica,sans-serif;grid-column:1/3}.modal-content .reference .doi{margin-top:12px;margin-top:.75rem;margin-bottom:36px;margin-bottom:2.25rem;display:-ms-flexbox;display:flex}.modal-content .button-collection{display:unset;-ms-flex-direction:column;flex-direction:column;grid-column:1/3}.modal-content .button-collection .button-collection__item{float:none}.modal-content .button-collection .button{margin-bottom:12px;margin-bottom:.75rem;width:100%}@media only all and (min-width:45.625em){.modal-content .button-collection{grid-column:1/3}.modal-content .button-collection .button-collection__item{float:left}.modal-content .button-collection .button{margin-bottom:12px;margin-bottom:.75rem;padding:15px 24px 14px;padding:.9375rem 1.5rem .875rem;line-height:1.5;text-decoration:none;width:auto}}.modal-content__body{margin-top:30px;margin-top:1.875rem;display:-ms-grid;display:grid;grid-column:1/3;-ms-grid-columns:1fr 224px;grid-template-columns:1fr 224px}.modal-content__body .button{margin-bottom:36px;margin-bottom:2.25rem;justify-self:center;grid-column:1/3;-ms-grid-row:3;grid-row:3}.modal-content__body .button.button--default{padding:15px 18px;padding:.9375rem 1.125rem}.modal-content__body .form-item{margin-bottom:36px;margin-bottom:2.25rem;grid-column:1/3}@media only all and (min-width:45.625em){.modal-content__body .button.button--default{justify-self:right;grid-column:2/3;-ms-grid-row:unset;grid-row:unset}.modal-content__body .form-item{grid-column:1/2}}.modal-content__close-button{padding:0 25px 0 0;padding:0 1.5625rem 0 0;background:url(/assets/patterns/img/icons/close.f00467a1.svg) right 4px no-repeat;color:#212121;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:700;grid-column:2/3;-ms-grid-row:1;grid-row:1;justify-self:end}.modal-nojs{visibility:hidden}.reference__title{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:1rem;line-height:1.5;font-weight:700;display:inline;text-decoration:none}.reference__authors_list{display:inline;list-style:none;margin:0;padding:0}.reference__author{font-size:1rem;line-height:1.5;display:inline;font-family:"Noto Sans",Arial,Helvetica,sans-serif;margin:0;padding:0}.reference__author:after{content:", "}.reference__author:last-of-type:after{content:""}.reference__authors_list_suffix{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:1rem;line-height:1.5}.reference__origin{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:1rem;line-height:1.5;font-size:1rem;line-height:1.5;display:inline;padding-bottom:0}.reference .doi__reference-spacing{margin-bottom:6px;margin-bottom:.375rem}.see-more-link{display:block;color:#212121;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:1rem;line-height:1.5;text-decoration:none}.social-media-sharers{-ms-flex-positive:0;flex-grow:0;-ms-flex-preferred-size:24px;flex-basis:24px}.content-header-journal .social-media-sharers,.modal-content .social-media-sharers{-ms-flex-preferred-size:auto;flex-basis:auto;margin:0;margin:0;margin-bottom:12px;margin-bottom:.75rem;padding:0;padding:0;-ms-flex-pack:center;justify-content:center}.content-header-journal .social-media-sharers li,.modal-content .social-media-sharers li{margin-left:0;margin-left:0;margin-right:0;margin-right:0;list-style:none}.content-header-journal .social-media-sharers li:last-child,.modal-content .social-media-sharers li:last-child{margin-right:0}.content-header__one-column-container .social-media-sharers{margin-bottom:0;margin-bottom:0}.social-media-sharer{display:inline-block}.social-media-sharer{background-color:#212121;border-radius:3px;color:#fff;margin:0 8px;height:24px;padding:2px 0;text-decoration:none;width:24px}.content-header-journal .social-media-sharer,.modal-content .social-media-sharer{background-color:transparent;border-radius:0;margin:0 9px}.content-header-journal .social-media-sharer:hover svg path{fill:#087acc}.content-header--image .social-media-sharer{background-color:transparent;border:1px solid #fff;padding:1px 0}.content-header:not(.content-header--image):not(.content-header-journal) .social-media-sharer:active,.content-header:not(.content-header--image):not(.content-header-journal) .social-media-sharer:hover{background-color:#087acc}.speech-bubble{background-color:#087acc;border:1px solid #087acc;color:#fff;border-radius:3px;display:block;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.875rem;line-height:2.57143;height:36px;height:2.25rem;padding:0;position:relative;text-align:center;text-decoration:none;width:42px;width:2.625rem}.speech-bubble[data-behaviour~=HypothesisOpener]{display:none}.speech-bubble:after{border-style:solid;border-width:20px;border-color:transparent;border-left-color:#087acc;border-right-width:0;content:"";height:0;width:0;left:8px;position:absolute;top:8px;z-index:-1}.speech-bubble__inner{display:inline-block}.speech-bubble--wrapped{font-size:.6875rem;line-height:1.36364;padding:13px 18px 14px;padding:.8125rem 1.125rem .875rem;display:block;font-weight:300;height:auto;min-width:2em;width:auto;justify-self:end}.speech-bubble--wrapped .speech-bubble--wrapped__prefix{font-size:.875rem;line-height:1.28571;display:inline-block;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:300;text-transform:uppercase}.speech-bubble--wrapped .speech-bubble__inner{margin-left:9px;margin-left:.5625rem;padding:3px 5px 0;padding:.1875rem .3125rem 0;font-size:.875rem;line-height:1.28571;background:#fff;border-radius:3px;color:#0769b0;font-weight:700;letter-spacing:.2px;min-width:26px;position:relative}.speech-bubble--wrapped .speech-bubble__inner:after{background:url(/assets/patterns/img/icons/speech-bubble-wrapped-triangle.65674a5a.svg) no-repeat;content:"";width:10px;height:10px;bottom:-10px;left:5px;position:absolute}.speech-bubble--has-placeholder.speech-bubble--wrapped .speech-bubble__inner{background:url(/assets/patterns/img/icons/speech-bubble-wrapped-placeholder.2fee63c5.svg) 8px 5px no-repeat #fff;text-indent:-9999px}.text-field,.text-field[type=text]{-webkit-appearance:none;-moz-appearance:none;appearance:none}.text-field{border:1px solid #e0e0e0;border-radius:3px;color:#212121;display:block;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:1rem;line-height:1.5;padding:11px 12px;padding:.6875rem .75rem;margin-bottom:6px;margin-bottom:.375rem;width:100%}.js .main-menu .to-top-link{display:none}.tabbed-navigation:not(.hidden)~.main-content-grid .article-section{scroll-margin-top:72px}.tabbed-navigation:not(.hidden)~.main-content-grid .article-section .article-download-links-list__heading{scroll-margin-top:72px}.article-section--first{border:none;padding-top:0}.article-section--first .article-section__header:first-child h2{margin-top:0;padding-top:0}.wrapper--content-with-header-and-aside .article-section--first .article-section__header:first-child h2{padding-top:21px;padding-top:1.3125rem}.article-section__header{position:relative}.article-section__header_text{color:#212121;margin:0;-ms-flex:1 0 80%;flex:1 0 80%;text-decoration:none}.article-section__body{font-family:"Noto Serif",serif;font-size:1rem;line-height:1.5;font-weight:400}.divider{border-bottom:1px solid #e0e0e0;grid-column:2/12;height:1px}@media only all and (min-width:75em){.divider{grid-column:1/13}.content-header__one-column .divider{grid-column:3/11;margin-left:-24px;margin-right:-24px}}@media only all and (min-width:45.625em){.main-content-grid{grid-column:2/12;-ms-grid-row:2;grid-row:2;min-width:0}.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal){display:-ms-grid;display:grid;-ms-grid-columns:(1fr)[12];grid-template-columns:repeat(12,1fr);grid-column-gap:24px}}@media only all and (min-width:56.25em){.main-content-grid{grid-column:2/9}}@media only all and (min-width:75em){.main-content-grid{margin-left:48px;margin-left:3rem;grid-column:3/10;-ms-grid-row:1;grid-row:1}.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal)>*{margin-left:0;margin-left:0;padding-right:0;padding-right:0}}@media only all and (min-width:45.625em){.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal)>*{grid-column:2/12}.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal) .main-content-grid,.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal) .secondary-column-grid{margin-top:0;margin-top:0;-ms-grid-row:auto;grid-row:auto}}@media only all and (min-width:75em){.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal) .main-content-grid{grid-column:3/9;grid-row:2/5;margin-right:-24px}.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal) .social-media-sharers--wrapper~.main-content-grid{grid-column:3/9}.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal) .social-media-sharers,.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal) .social-media-sharers--wrapper{display:block}.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal) .social-media-sharers--wrapper{grid-column:10/11;grid-row:2/3;justify-self:end}.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal) .social-media-sharers--wrapper .svg-background-image{margin-left:8px;margin-left:.5rem}.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal) .side-section-wrapper__link{display:block}.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal) .secondary-column-grid{grid-column:10/13;grid-row:2/3}.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal) .social-media-sharers--wrapper~.secondary-column-grid{grid-row:3/5}}.authors{margin-bottom:24px;margin-bottom:1.5rem}.content-header-grid__main .authors{margin:0 0 36px}@media only all and (max-width:45.563rem){.content-header-journal .authors{display:contents}.authors .institution_list{border:0;clip:rect(0 0 0 0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}}.author_list{margin:0;padding:0}@media only all and (max-width:45.625em){.content-header-journal .author_list{padding:0}}.content-header-grid__main .author_list{padding:0 0 24px}.author_list_item{display:inline;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:1rem;line-height:1.5;list-style-type:none;padding:0;text-align:center}.author_list_item:first-of-type:before{content:""}.author_list_item:before{content:", "}.author_suffix{white-space:nowrap}li.institution_list_item:last-child .institution_separator{display:none}.author_link{color:inherit;text-decoration:inherit}.author_icon{padding-top:1px;vertical-align:text-top}.institution_list{margin:0;padding:0}.institution_list_item{display:inline;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.875rem;line-height:1.71429;font-weight:500;list-style-type:none;padding:0}.button-collection{display:table;margin:0;padding:0;margin-bottom:24px;margin-bottom:1.5rem;margin-top:-24px;margin-top:-1.5rem}@supports (display:flex){.button-collection{display:-ms-flexbox;display:flex;-ms-flex-wrap:wrap;flex-wrap:wrap;-ms-flex-align:center;align-items:center}}.button-collection.button-collection--inline{margin-top:0;margin-top:0;display:inline-block}.button-collection.button-collection--inline .button-collection__item{margin-top:0;margin-top:0;margin-right:12px;margin-right:.75rem;position:relative}.button-collection.button-collection--inline .button-collection__item:last-child{margin-right:0;margin-right:0}.button-collection__item{float:left;list-style:none;margin-top:24px;margin-top:1.5rem;margin-right:10px;margin-right:.625rem}.compact-form__container{border:none;margin:0 auto;max-width:440px;max-width:27.5rem;padding:0;position:relative}.search-box__inner .compact-form__container{max-width:none}.compact-form__input{background-color:#fff;border:1px solid #e0e0e0;border-right:none;border-radius:3px;display:block;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:1rem;line-height:1.5;padding:11px 55px 11px 12px;padding:.6875rem 3.4375rem .6875rem .75rem;width:100%}.compact-form__submit{background:url(/assets/patterns/img/icons/arrow-forward.7f8fc46b.png);background:url(/assets/patterns/img/icons/arrow-forward.663dc5c2.svg),linear-gradient(transparent,transparent);background-color:#087acc;background-position:50% 50%;background-repeat:no-repeat;border:none;border-radius:0 3px 3px 0;color:#fff;height:48px;height:3rem;position:absolute;right:0;top:0;width:47px;width:2.9375rem}.compact-form__reset{border:0;clip:rect(0 0 0 0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}.contextual-data{font-size:.875rem;line-height:1.71429;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:400;color:#757575;font-size:.75rem;line-height:2}.content-header .contextual-data{border-bottom:none}.content-header__one-column .contextual-data{display:-ms-flexbox;display:flex}.content-header__one-column .contextual-data:after{margin-left:3px;margin-left:.1875rem;margin-right:3px;margin-right:.1875rem;content:"\00a0\2022\00a0";font-weight:700;white-space:pre}.contextual-data__list{border-bottom:1px solid #e0e0e0;margin:0;padding:11px 0;padding:.6875rem 0;text-align:center}.content-header .contextual-data__list{border-bottom:none;padding:0;padding:0;text-align:right}.content-aside .contextual-data__list{margin-bottom:24px;margin-bottom:1.5rem;padding:0;padding:0;border:none;display:-ms-flexbox;display:flex}.content-aside .contextual-data__list .contextual-data__item{padding:0;padding:0;font-size:.875rem;line-height:1.71429}.content-aside .contextual-data__list .contextual-data__item:before{content:", "}.content-aside .contextual-data__list .contextual-data__item:first-child:before{content:""}.contextual-data__item{display:inline-block;font-size:.875rem;line-height:1.71429;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:400;color:#757575;font-size:.75rem;line-height:2;margin:0;padding:0 5px 0 0;padding:0 .3125rem 0 0}.contextual-data__item .contextual-data__counter,.contextual-data__item a{color:inherit}.contextual-data__item a:hover{color:#087acc}.content-header .contextual-data__item{font-size:.875rem;line-height:1.71429;display:list-item;padding:0;list-style:none}.contextual-data__item__hypothesis_opener{display:none}.js .contextual-data__item__hypothesis_opener{color:#087acc;display:inline-block}.contextual-data__cite_wrapper{border-bottom:1px solid #e0e0e0;padding-top:12px;padding-top:.75rem;padding-bottom:11px;padding-bottom:.6875rem;padding-left:0;padding-right:0;text-align:center}.contextual-data__cite{display:none}.contextual-data__counter{color:#212121;font-weight:700}.content-header__footer .contextual-data__counter{font-weight:400}@media only screen and (min-width:56.25rem){.contextual-data{border-bottom:1px solid #e0e0e0}.contextual-data__list{-ms-flex-item-align:center;-ms-grid-row-align:center;align-self:center;border-bottom:none;display:inline-block;text-align:left}.content-header__one-column .contextual-data__list{-ms-flex-item-align:auto;-ms-grid-row-align:auto;align-self:auto}.contextual-data__cite_wrapper{border-bottom:none;float:right;margin-left:auto;padding:11px 0;padding:.6875rem 0;text-align:start}.contextual-data__cite{-ms-flex-item-align:center;-ms-grid-row-align:center;align-self:center;display:inline-block;-ms-flex:1;flex:1;text-align:right;padding:0 5px 0 0;padding:0 .3125rem 0 0}}.highlight-item{max-width:1114px;max-width:69.625rem;margin-bottom:24px;margin-bottom:1.5rem;color:#212121;display:-ms-grid;display:grid;grid-auto-flow:dense;-ms-grid-columns:6fr 6fr;grid-template-columns:6fr 6fr;list-style-type:none;overflow:hidden;position:relative}@media only screen and (min-width:30em){.highlight-item{margin-bottom:36px;margin-bottom:2.25rem}}@media only screen and (min-width:45.625em){.highlight-item{display:-ms-grid;display:grid;grid-auto-flow:column;-ms-grid-columns:8fr 4fr;grid-template-columns:8fr 4fr}}@media only screen and (min-width:75em){.highlight-item{margin-bottom:0;margin-bottom:0;grid-auto-flow:row;-ms-grid-columns:auto;grid-template-columns:auto}}.highlight-item__meta .meta{font-size:.875rem;line-height:1.71429;color:inherit}@media only all and (min-width:45.625em){.highlight-item__meta .meta{display:-ms-flexbox;display:flex}}.highlight-item__meta .meta__type:hover{color:inherit}.jump-menu__wrapper{margin-top:24px;margin-top:1.5rem;background-color:#fff}.jump-menu__list{border-left:2px solid #edeff4;list-style:none;margin:0;padding:0;position:-webkit-sticky;position:sticky;top:110px}.jump-menu__item{margin:0;margin:0;margin-bottom:24px;margin-bottom:1.5rem;font-size:.875rem;line-height:1.71429;font-family:"Noto Sans",Arial,Helvetica,sans-serif}.jump-menu{padding-left:18px;padding-left:1.125rem;color:#757575;display:block;text-decoration:none}.wrapper--content .jump-menu__wrapper{display:none}.main-menu__section{padding-bottom:15px;padding-bottom:.9375rem}.main-menu__title{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.875rem;line-height:1;font-weight:700;text-transform:uppercase;margin:0;padding:0;padding-bottom:5px;padding-bottom:.3125rem;text-transform:uppercase}.main-menu__title-container{padding-top:30px;padding-top:1.875rem;padding-bottom:30px;padding-bottom:1.875rem}@media only screen and (min-width:56.25em){.main-menu__title-container{padding-top:42px;padding-top:2.625rem}}@media only screen and (min-width:75em){.wrapper--content .jump-menu__wrapper{display:block;grid-column:1/3;-ms-grid-row:3;grid-row:3}.main-menu__title-container{padding-top:54px;padding-top:3.375rem}}.main-menu__title-container .site-header__title{float:none}.main-menu__list{padding-left:0;padding-left:0}.main-menu__list_item{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:1rem;line-height:1.5;font-size:1rem;line-height:3;margin:0;padding:0;text-align:center;padding-bottom:24px;padding-bottom:1.5rem;display:block;line-height:0;text-align:left}@media only screen and (min-width:56.25em){.main-menu__list_item.hidden-wide{display:none}}.main-menu__list_item.end-of-group{margin-bottom:24px;margin-bottom:1.5rem;border-bottom:1px solid #e0e0e0}.main-menu__list_item:last-child{padding-bottom:48px;padding-bottom:3rem}.main-menu__list_link{font-size:.875rem;line-height:1.71429;color:#212121;font-weight:700;text-decoration:none}.main-menu__list_link:hover{color:#087acc}.main-menu__close_control{font-size:.875rem;line-height:1.71429;padding:0;padding:0;margin-top:8px;margin-top:.5rem;background:url(/assets/patterns/img/icons/close.f00467a1.svg) 49px 3px no-repeat;background-size:14px;border:none;color:#212121;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:700;float:right;text-align:left;width:68px}.main-menu__close_control:hover{background-image:url(/assets/patterns/img/icons/close-blue.35ee140b.svg);color:#087acc}.main-menu--js{display:none}.main-menu--js .main-menu__container{display:block}.main-menu--js.main-menu--shown{background-color:#fff;box-sizing:border-box;color:#212121;display:block;float:left;height:100vh;left:-3000px;max-width:100%;overflow:auto;position:fixed;top:0;transform:translate3d(3000px,0,0);width:100%;z-index:40}@media only screen and (min-width:56.25em){.main-menu--js.main-menu--shown{width:320px}.nav-primary{border-left:1px solid #e0e0e0;height:24px}}.main-menu--js .main_menu__quit{display:none}.main-menu__container:hover{color:#087acc}.main-menu__container .site-header__logo_link{display:block;float:none;height:35px;width:88px}.meta{font-size:.875rem;line-height:1.71429;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:400;color:#757575;font-size:.75rem;line-height:2}.content-header-journal .meta{font-size:.875rem;line-height:1.71429}.highlights .meta{display:block;overflow:hidden;text-overflow:ellipsis;white-space:nowrap}.meta__type{color:inherit;text-decoration:none}.meta__type+.date::before{content:"\00a0\2022\00a0";font-weight:700}.teaser--main .meta__type{font-size:.875rem;line-height:1.28571}.teaser--main .meta__type+.date::before{content:""}@media only all and (min-width:30em){.content-header-journal .social-media-sharers li,.modal-content .social-media-sharers li{margin-left:8px;margin-left:.5rem;margin-right:8px;margin-right:.5rem}.teaser--main .meta__type+.date::before{content:"\00a0\2022\00a0";font-weight:700}}.teaser .meta__type+.date::before{content:""}a.meta__type:hover{color:#0769b0}.meta>a.meta__type:last-child:after{content:""}.teaser .meta__status,.teaser .meta__type,.teaser .meta__version{font-size:.875rem;line-height:1.42857;color:#757575;display:inline-block}.teaser .meta__status:after,.teaser .meta__type:after,.teaser .meta__version:after{color:#757575;content:"\00a0\2022\00a0";display:inline-block;font-weight:700;width:13px}.teaser .meta__status{color:#212121}.teaser .meta__status-circle{margin-bottom:1px;margin-bottom:.0625rem;margin-right:8px;margin-right:.5rem;margin-left:1px;margin-left:.0625rem;background-color:#edeff4;border-radius:50%;display:inline-block;height:8px;width:8px}.teaser .meta__status-circle-not-revised{background-color:#f29524}.teaser .meta__status-circle-revised{background-color:#42aea4}.teaser .meta__status-circle-vor{background-color:#087acc}@media only screen and (min-width:45.625em){.button-collection__item{margin-left:0;margin-left:0;margin-right:24px;margin-right:1.5rem}}.search-box{position:relative}.search-box:not(.search-box--js){padding-top:48px;padding-top:3rem}.search-box__inner{max-width:1114px;padding:0 6%;position:relative}.wrapper .search-box__inner{padding-left:0;padding-right:0}@media only all and (min-width:1114px){.search-box__inner{margin:0 auto;padding:0 66px;padding:0 4.125rem}}.nav-primary{margin-top:8px;margin-top:.5rem;background-color:#fff;clear:right;position:relative;z-index:10}.nav-primary__list{padding-left:0;padding-left:0;margin-bottom:0;margin-bottom:0}.nav-primary__item{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.875rem;line-height:1.71429;font-weight:700;color:#212121;float:left;list-style-type:none}@supports (display:flex){.nav-primary__list{-ms-flex-align:center;align-items:center;display:-ms-flexbox;display:flex;padding-top:0}.nav-primary__item{padding-top:0}.nav-secondary__item{padding-top:0}}.nav-primary a:link,.nav-primary a:visited{color:#212121;text-decoration:none}.nav-primary__item{display:none}.nav-primary__item--first{display:list-item}.nav-primary__item--first a{background:url(/assets/patterns/img/patterns/molecules/nav-primary-menu-ic.ac4e582f.svg) 50px -2px no-repeat;background-size:24px;display:-ms-flexbox;display:flex;width:74px}@media only all and (max-width:21.25rem){.nav-primary__item--first{padding:0}}@media only screen and (min-width:56.25em){.nav-primary__item{margin-left:24px;margin-left:1.5rem;display:list-item}.nav-primary__item a{color:#212121}.nav-primary__item--first{margin-left:21px;margin-left:1.3125rem;margin-top:-2px;margin-top:-.125rem}.nav-primary__item--first a{background-position-x:0;background-position-y:0;text-indent:-9999px;width:24px}}.nav-secondary{margin-top:8px;margin-top:.5rem;background-color:#fff;display:none;margin-left:auto;position:relative;z-index:15}.nav-secondary__list{height:40px;height:2.5rem;margin:0;margin:0;padding:0;padding:0}.nav-secondary__item{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.875rem;line-height:1.71429;font-weight:700;color:#212121;float:left;list-style-type:none}.nav-secondary__list .nav-secondary__item.nav-secondary__item--search a{display:none}@media only screen and (min-width:56.25em){.nav-secondary{display:inline-block}.nav-secondary__list .nav-secondary__item.nav-secondary__item--search a{margin-right:24px;margin-right:1.5rem;background:url(/assets/patterns/img/patterns/molecules/nav-secondary-search-black-ic.a3f2d6fa.svg) no-repeat;background-size:21px;display:block;text-indent:-9999px;width:24px}}@media only screen and (min-width:75em){.nav-secondary__list .nav-secondary__item.nav-secondary__item--search a{background-position-x:50px;background-position-y:0;text-indent:0;width:70px}}.nav-secondary__list .nav-secondary__item.nav-secondary__item--alert a{display:none}.nav-secondary__item--hide-narrow{display:none}.nav-secondary__item--hide-narrow .button--default.button--extra-small{padding-left:8px;padding-left:.5rem;padding-right:8px;padding-right:.5rem;font-weight:400}.nav-secondary__item a:not(.login-control__non_js_control_link){text-decoration:none}.nav-secondary__item a:not(.login-control__non_js_control_link):link,.nav-secondary__item a:not(.login-control__non_js_control_link):visited{color:#212121}.nav-secondary__item a:not(.login-control__non_js_control_link).button:link,.nav-secondary__item a:not(.login-control__non_js_control_link).button:visited{color:#fff}@media only screen and (min-width:56.25em){.nav-secondary__list .nav-secondary__item.nav-secondary__item--alert a{margin-right:24px;margin-right:1.5rem;background:url(/assets/patterns/img/patterns/molecules/nav-secondary-alert-black-ic.e9bb80fe.svg) no-repeat;background-size:21px;display:block;text-indent:-9999px;width:24px}.nav-secondary__item--hide-narrow{display:list-item}}.tabbed-navigation{margin-bottom:24px;margin-bottom:1.5rem;background-color:#fff;border-bottom:1px solid #e0e0e0;border-top:1px solid #e0e0e0;grid-column:2/12;-ms-grid-row:1;grid-row:1;-ms-flex-pack:center;justify-content:center;position:-webkit-sticky;position:sticky;top:-1px;z-index:9}@media only all and (min-width:62.5em){.tabbed-navigation{grid-column:1/9}}.tabbed-navigation:not(.hidden)~.main-content-grid{-ms-grid-row:2;grid-row:2}.wrapper .tabbed-navigation{margin-left:-24px;margin-left:-1.5rem;margin-right:-24px;margin-right:-1.5rem}@media only all and (min-width:30em){.tabbed-navigation{margin-bottom:36px;margin-bottom:2.25rem}.wrapper .tabbed-navigation{margin-left:-48px;margin-left:-3rem;margin-right:-48px;margin-right:-3rem}}@media only all and (min-width:45.625em){.wrapper .tabbed-navigation{margin-left:0;margin-left:0;margin-right:0;margin-right:0}.content-aside .content-aside__second-column{width:100%}}@media only all and (min-width:75em){.tabbed-navigation{grid-column:1/10}.wrapper .tabbed-navigation{margin-right:36px;margin-right:2.25rem}}.tabbed-navigation__tab-label{font-size:1rem;line-height:1.5;display:inline}.tabbed-navigation__tab-label.tabbed-navigation__tab-label--active{border-bottom:4px solid #087acc;font-weight:600}.tabbed-navigation__tab-label.tabbed-navigation__tab-label--active a{color:#212121}.tabbed-navigation__tab-label a{padding:24px 14px;padding:1.5rem .875rem;color:#757575;display:block;font-family:"Noto Sans",Arial,Helvetica,sans-serif;text-decoration:none}.tabbed-navigation__tab-label a:hover{color:#212121}.tabbed-navigation__tab-label--long{display:none}@media only all and (min-width:30em){.tabbed-navigation__tab-label a{padding:24px 18px 20px;padding:1.5rem 1.125rem 1.25rem}.tabbed-navigation__tab-label--long{display:inline}}.tabbed-navigation__tab-label--side-by-side{display:none}@media only all and (min-width:30em){.tabbed-navigation__tab-label--side-by-side{display:inline}}.tabbed-navigation__tabs{display:-ms-inline-flexbox;display:inline-flex;list-style:none;margin:0;padding:0;width:100%;-ms-flex-pack:center;justify-content:center}@media only all and (min-width:30em){.tabbed-navigation__tabs{display:-ms-flexbox;display:flex;-ms-flex-wrap:wrap;flex-wrap:wrap;max-height:72px;overflow:hidden}}.content-aside{padding-top:12px;padding-top:.75rem}@media only screen and (min-width:30em){.content-aside{padding-top:24px;padding-top:1.5rem}}@media only screen and (min-width:45.625em){.content-aside{display:-ms-grid;display:grid;-ms-grid-columns:(1fr)[12];grid-template-columns:repeat(12,1fr)}}.content-aside .button-collection.button-collection--inline{margin-bottom:24px;margin-bottom:1.5rem}.content-aside .button-collection.button-collection--inline .button-collection__item{margin-bottom:12px;margin-bottom:.75rem}.content-aside .contextual-data{border:none}.content-aside .contextual-data__list{border:none;display:inline-block;text-align:left}.content-aside .contextual-data__list .contextual-data__item{padding:0;padding:0}.content-aside .contextual-data__list .contextual-data__item:before{content:""}.content-aside .contextual-data__list .contextual-data__item:after{content:"\00a0\2022\00a0";display:inline-block;width:13px}.content-aside .contextual-data__list .contextual-data__item:last-child:after{content:""}.content-aside .contextual-data__list .contextual-data__item.no-separator:after{content:""}.content-aside .content-aside__second-column{padding-bottom:24px;padding-bottom:1.5rem}@media only all and (min-width:62.5em){.content-aside .content-aside__second-column{padding-bottom:0;padding-bottom:0}}@media only screen and (min-width:45.625em){.content-aside .content-aside__column-wrapper{display:-ms-flexbox;display:flex;grid-column:2/12}.content-aside .content-aside__column-wrapper .content-aside__first-column{padding-right:48px;padding-right:3rem;width:50%}.content-aside .content-aside__column-wrapper .content-aside__first-column+.content-aside__second-column{width:50%}}.content-aside .content-aside__definition-list{margin-bottom:36px;margin-bottom:2.25rem}@media only screen and (min-width:62.5em){.content-aside{padding-top:86px;padding-top:5.375rem;-ms-flex-align:end;align-items:flex-end;-ms-flex-item-align:start;align-self:flex-start;display:-ms-flexbox;display:flex;-ms-flex-direction:column;flex-direction:column;z-index:5}.content-aside .content-aside__column-wrapper{display:block;max-width:260px;padding-left:10px;padding-left:.625rem}.content-aside .content-aside__column-wrapper .content-aside__first-column{padding-right:0;padding-right:0;width:100%}.content-aside .content-aside__column-wrapper .content-aside__first-column+.content-aside__second-column{width:100%}.content-aside .content-aside__definition-list{margin-bottom:48px;margin-bottom:3rem;padding-left:6px;padding-left:.375rem}}.content-aside .definition-list{margin:0;margin:0;-ms-grid-row:1;grid-row:1;overflow:hidden}@media only screen and (min-width:62.5em){.wrapper--content-with-header-and-aside{display:-ms-grid;display:grid;grid-column-gap:24px;-ms-grid-columns:(1fr)[12];grid-template-columns:repeat(12,1fr)}.wrapper--content-with-header-and-aside .content-header.content-header__has-aside{grid-column:1/9;-ms-grid-row:2;grid-row:2}.wrapper--content-with-header-and-aside .content-header .content-container-grid{display:block}.wrapper--content-with-header-and-aside .content-aside{grid-column:9/13;grid-row:2/4}}@media only screen and (min-width:75em){.nav-secondary__list .nav-secondary__item.nav-secondary__item--alert a{background-position-x:50px;background-position-y:0;text-indent:0;width:70px}.wrapper--content-with-header-and-aside .content-header.content-header__has-aside{padding-right:36px;padding-right:2.25rem;grid-column:1/10}.wrapper--content-with-header-and-aside .content-aside{grid-column:10/13}}.wrapper--content-with-header-and-aside>.wrapper{padding:0;padding:0}.wrapper--content-with-header-and-aside .wrapper--content{grid-column:1/13;-ms-grid-row:3;grid-row:3}@media only screen and (min-width:45.625em){.wrapper--content-with-header-and-aside .wrapper--content .main-content-grid{grid-column:2/12;-ms-grid-row:3;grid-row:3}}@media only screen and (min-width:62.5em){.wrapper--content-with-header-and-aside .wrapper--content{padding-top:24px;padding-top:1.5rem}.wrapper--content-with-header-and-aside .wrapper--content .main-content-grid{grid-column:1/9}}@media only screen and (min-width:75em){.wrapper--content-with-header-and-aside .wrapper--content{padding-top:36px;padding-top:2.25rem}.wrapper--content-with-header-and-aside .wrapper--content .main-content-grid{margin-left:36px;margin-left:2.25rem;margin-right:36px;margin-right:2.25rem;grid-column:3/10;-ms-grid-row:3;grid-row:3}}.content-header-grid-top{margin-top:24px;margin-top:1.5rem;margin-bottom:24px;margin-bottom:1.5rem}.content-header-grid-top .content-header__subject_list{margin-bottom:0;margin-bottom:0;text-align:left}@media only all and (min-width:45.625em){.content-container-grid{display:-ms-grid;display:grid;-ms-grid-columns:(1fr)[12];grid-template-columns:repeat(12,1fr);grid-column-gap:24px;max-width:1114px;padding:0}.content-header-grid-top{grid-column:2/12}}@media only all and (min-width:75em){.content-header-grid-top{grid-column:1/13}.page--magazine .content-header-grid-top{grid-column:2/12}.content-header__one-column .content-header-grid-top{grid-column:3/11;margin-left:-24px}}.content-header-grid__main{margin-bottom:24px;margin-bottom:1.5rem}.social-media-page--wrapper .content-header-grid__main{margin-bottom:36px;margin-bottom:2.25rem}.social-media-page--wrapper[data-item-type=digest] .content-header-grid__main{margin-bottom:24px;margin-bottom:1.5rem}.content-header__one-column .content-header-grid__main .content-header__footer{display:block}.content-header__one-column .content-header-grid__main .content-header__footer .content-header__footer-column-left{margin-bottom:24px;margin-bottom:1.5rem;display:-ms-flexbox;display:flex}.content-header-grid__main .content-header__icons li{display:inline-block}.content-header-grid__main .date{font-size:.875rem;line-height:1.71429}@media only all and (min-width:30em){.content-header-grid__main .content-header__footer{display:-ms-flexbox;display:flex;width:100%}.content-header-grid__main .doi:before{margin-left:3px;margin-left:.1875rem;content:"\00a0\2022\00a0";font-weight:700}.content-header-grid__main{margin-bottom:36px;margin-bottom:2.25rem;grid-column:1/10;width:100%}}@media only all and (min-width:45.625em){.social-media-page--wrapper .content-header-grid__main{margin-bottom:48px;margin-bottom:3rem}.content-header__one-column .content-header-grid__main .content-header__footer{display:-ms-flexbox;display:flex}.content-header__one-column .content-header-grid__main .content-header__footer .content-header__footer-column-left{margin-bottom:0;margin-bottom:0}.content-header-grid__main{grid-column:2/12;-ms-grid-row:2;grid-row:2}}@media only all and (min-width:56.25em){.global-wrapper.social-media-page--wrapper .main .content-header:not(.content-header-journal)>*{grid-column:3/11}.content-header .contextual-data__list{text-align:left}.content-header-grid__main{margin-bottom:48px;margin-bottom:3rem;grid-column:2/10;padding-right:48px}.content-header__one-column .content-header-grid__main{grid-column:2/12;padding-right:0}.wrapper--content-with-header-and-aside .content-header-grid__main{grid-column:2/12}}@media only all and (min-width:75em){.content-header-grid__main{grid-column:1/10;padding-right:0}.page--magazine .content-header-grid__main{grid-column:2/10;padding-right:48px}.content-header__one-column .content-header-grid__main{grid-column:3/12;margin-left:-24px;padding-right:46px}}.content-header__footer-inner{font-size:.875rem;line-height:1.71429;display:-ms-flexbox;display:flex}.content-header__one-column .social-media-sharers{display:inline-block}.content-header__one-column .social-media-sharers li{display:inline;margin-left:0;margin-right:0}.content-header__one-column .social-media-sharers li a:last-child{margin-right:0}.content-header__footer .content-header__one-column{display:-ms-flexbox;display:flex;width:100%}.content-header-grid__main .content-header__one-column{padding-right:0;grid-column:1/13}.content-header__one-column-container{display:-ms-flexbox;display:flex;margin-left:auto}.content-header__has-aside .content-container-grid{display:block}@media only all and (min-width:45.625em){.content-header__has-aside .content-container-grid{display:-ms-grid;display:grid}}.content-header__has-aside .content-container-grid .content-header-grid-top,.content-header__has-aside .content-container-grid .content-header-grid__main,.content-header__has-aside .content-container-grid .divider{margin-left:0;margin-left:0}.content-header__has-aside .content-container-grid .divider{display:none}.content-header__has-aside .content-header__icons{vertical-align:middle}@media only all and (min-width:20em){.content-header__has-aside .content-header__icons{display:inline-block}}.content-header__has-aside .content-header-grid-top{margin-bottom:12px;margin-bottom:.75rem}@media only all and (min-width:30em){.content-header__has-aside .content-header-grid-top{margin-bottom:24px;margin-bottom:1.5rem}}@media only all and (min-width:45.625em){.content-header__has-aside .content-header-grid-top{margin-bottom:12px;margin-bottom:.75rem}.content-header__has-aside .content-header-grid__main .content-header__footer .content-header__footer-column-left{margin-bottom:24px;margin-bottom:1.5rem}}.content-header__has-aside .content-header-grid__main{margin-bottom:24px;margin-bottom:1.5rem}.content-header__has-aside .content-header-grid__main .content-header__body{margin-bottom:24px;margin-bottom:1.5rem}.content-header__has-aside .content-header-grid__main .content-header__footer .content-header__footer-column-left{display:inline-block}.content-header__has-aside .content-header-grid__main .authors{margin-bottom:24px;margin-bottom:1.5rem}.content-header__has-aside .content-header-grid__main .author_link_highlight{padding-top:0;padding-top:0}.content-header__has-aside .content-header-grid__main .author_list{padding-bottom:12px;padding-bottom:.75rem}.content-header-profile{padding-top:48px;padding-top:3rem;padding-bottom:24px;padding-bottom:1.5rem;box-sizing:content-box;max-width:1114px;max-width:69.625rem;margin:auto;font-family:"Noto Sans",Arial,Helvetica,sans-serif;padding-left:6%;padding-right:6%;position:relative;text-align:center}@media only all and (min-width:45.625em){.content-header-profile{padding-bottom:48px;padding-bottom:3rem}}.content-header-profile__display_name{font-size:1.25rem;line-height:2.4;font-weight:700;margin:0;padding:0}.content-header-profile__details{font-size:1rem;line-height:1.5}.content-header-profile__affiliations{margin:0;padding:0;list-style:none}.content-header-profile__affiliations:empty{display:none}.content-header-profile__affiliation{display:inline;font-family:"Noto Sans",Arial,Helvetica,sans-serif}.content-header-profile__affiliation:after{content:"; "}.content-header-profile__affiliation:last-child:after{content:""}.content-header-profile__orcid .orcid__id{color:inherit}.content-header-profile__email{word-break:break-all}.content-header-profile__links{list-style:none;margin:0;padding:0}.js .content-header-profile__links{display:none}.content-header-profile__link{color:#212121;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.875rem;line-height:1.71429;font-weight:400;text-decoration:underline;text-transform:none}.content-header-profile__link:hover{text-decoration:underline}.content-header-profile__link--logout{position:absolute;right:24px;top:24px}.content-header-simple{padding-top:48px;padding-top:3rem;padding-bottom:24px;padding-bottom:1.5rem;padding-left:6%;padding-right:6%;text-align:center}@media only all and (min-width:45.625em){.content-header-simple{padding-bottom:48px;padding-bottom:3rem}.social-media-page--wrapper .content-header.wrapper:after{grid-column:2/12}}.content-header-simple__title{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:700;font-size:1.625rem;line-height:1.15385;color:#212121;font-size:1.25rem;line-height:1.2;margin:0;padding:0}.content-header-simple__strapline{color:#212121;font-family:"Noto Serif",serif;font-size:1rem;line-height:1.5;font-weight:400;margin:0;padding:0}.clean .content-header-simple{padding-left:0;padding-left:0;text-align:left}.header-wrapper .content-header-simple{padding:0;padding:0}.header-wrapper .content-header-simple__title{font-size:2rem;line-height:1.25}@media only screen and (min-width:56.25em){.header-wrapper .content-header-simple__title{font-size:2.625rem;line-height:1.2381}}.header-wrapper .content-header-simple__strapline{margin-top:24px;margin-top:1.5rem;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:700}.content-header{box-sizing:content-box;max-width:1114px;max-width:69.625rem;margin:auto;color:#212121;padding-top:0;padding-bottom:23px;padding-bottom:1.4375rem;position:relative;text-align:center}.content-header.wrapper{padding-bottom:0}.content-header.wrapper:after{border-bottom:1px solid #e0e0e0;content:"";display:block;width:100%}.content-header-journal{text-align:left;position:static}.content-header-journal.wrapper:after{border-bottom:none}@media only all and (min-width:75em){.content-header__has-aside .content-header-grid__main{margin-bottom:0;margin-bottom:0}.wrapper--content-with-header-and-aside .content-header-journal{margin-left:0;margin-left:0}}.content-header--read-more .content-header__subject_list{padding-left:0;padding-left:0;padding-right:0;padding-right:0;width:100%}.content-header-image-wrapper--no-credit{padding-bottom:48px;padding-bottom:3rem}.content-header__top{margin-top:12px;margin-top:.75rem;text-align:left}.content-header__top~.content-header__body{margin-top:24px;margin-top:1.5rem;margin-bottom:48px;margin-bottom:3rem}.content-header__body{margin-top:48px;margin-top:3rem;margin-bottom:24px;margin-bottom:1.5rem}.content-header--header .content-header__body{margin-top:12px;margin-top:.75rem}.content-header--image{border-bottom:none;color:#fff;height:264px;overflow:hidden;padding-bottom:0}@media only all and (min-width:56.25em){.content-header__has-aside .content-header-grid__main{padding-right:0;padding-right:0}.social-media-page--wrapper .content-header.wrapper:after{grid-column:3/11}.content-header--image{min-height:336px}}.content-header--image .content-header__body{height:132px;display:-ms-flexbox;display:flex;-ms-flex-direction:column;flex-direction:column;-ms-flex-align:center;align-items:center;-ms-flex-line-pack:center;align-content:center;-ms-flex-pack:center;justify-content:center;padding:0 12px;padding:0 .75rem}.content-header-journal .content-header--image .content-header__body{height:168px}.content-header--has-social-media-sharers .content-header--image .content-header__body{min-height:192px}.content-header-journal .content-header--has-social-media-sharers .content-header--image .content-header__body{height:216px}@media only all and (min-width:45.625em){.content-header--header .content-header__body{margin-top:24px;margin-top:1.5rem}.content-header-grid__main .content-header__body{margin-bottom:36px;margin-bottom:2.25rem;margin-top:0;margin-top:0}.content-header--image{height:288px}.content-header--image .content-header__body{display:-ms-flexbox;display:flex;-ms-flex-direction:column;flex-direction:column;-ms-flex-align:center;align-items:center;-ms-flex-line-pack:center;align-content:center;-ms-flex-pack:center;justify-content:center;padding:0 48px;padding:0 3rem;margin-top:48px;margin-top:3rem;margin-bottom:24px;margin-bottom:1.5rem}.content-header-journal .content-header--image .content-header__body{height:120px}}.content-header--image .social-media-sharers{position:absolute;left:0;right:0;bottom:52px}.content-header-journal .content-header--image .social-media-sharers{bottom:28px}@media only all and (max-width:45.5625em){.content-header--image.content-header--has-profile .content-header__body{display:block;margin-top:0;margin-bottom:0}}.content-header__title{font-size:2.25rem;line-height:1.33333;margin-top:0;margin-top:0;margin-bottom:24px;margin-bottom:1.5rem}.content-header-journal .content-header__title{margin-top:6px;margin-top:.375rem;margin-bottom:12px;margin-bottom:.75rem}@media only all and (min-width:45.625em){.content-header__title{font-size:2.5625rem;line-height:1.17073}}@media only all and (min-width:56.25em){.content-header--image .content-header__body{height:168px}.content-header--has-social-media-sharers .content-header--image .content-header__body{min-height:216px}.content-header__title{font-size:2.875rem;line-height:1.56522}}.content-header--header .content-header__title,.content-header--read-more .content-header__title{font-size:1.8125rem;line-height:1.24138}.content-header__title_link{color:inherit;text-decoration:inherit}@media only all and (min-width:45.625em){.content-header--header .content-header__title,.content-header--read-more .content-header__title{font-size:2.25rem;line-height:1.33333}.content-header--image .content-header__body{margin-top:72px;margin-top:4.5rem}}.content-header--image .content-header__title{font-size:2.5625rem;line-height:1.17073;margin-bottom:0;height:132px;display:-ms-flexbox;display:flex;-ms-flex-pack:center;justify-content:center;-ms-flex-item-align:center;align-self:center;-ms-flex-align:center;align-items:center}@media only all and (min-width:45.625em){.content-header--image .content-header__title{font-size:3.25rem;height:auto;display:block}}.content-header--image .content-header__title.content-header__title--xx-short{font-size:2.875rem}@media only all and (min-width:30em){.content-header__has-aside .content-header-grid__main .content-header__footer .content-header__footer-column-left{display:-ms-flexbox;display:flex}.content-header--image .content-header__title.content-header__title--xx-short{font-size:3.25rem}}.content-header--image .content-header__title.content-header__title--x-short{font-size:2.5625rem}@media only all and (min-width:45.625em){.content-header--image .content-header__title.content-header__title--x-short{font-size:2.875rem}}@media only all and (min-width:56.25em){.content-header--image .content-header__title{font-size:3.625rem;line-height:1.24138}.content-header--image .content-header__title.content-header__title--x-short{font-size:3.25rem}}.content-header--image .content-header__title.content-header__title--short{font-size:1.875rem}@media only all and (min-width:30em){.content-header--image .content-header__title.content-header__title--short{font-size:2.25rem}}@media only all and (min-width:45.625em){.content-header--image .content-header__title.content-header__title--short{font-size:2.5625rem}}@media only all and (min-width:56.25em){.content-header--image .content-header__title.content-header__title--short{font-size:2.875rem}}@media only all and (min-width:75em){.content-header--image .content-header__title.content-header__title--short{font-size:3.25rem}}.content-header--image .content-header__title.content-header__title--medium{font-size:1.625rem}@media only all and (min-width:30em){.content-header--image .content-header__title.content-header__title--medium{font-size:1.875rem}}@media only all and (min-width:45.625em){.content-header--image .content-header__title.content-header__title--medium{font-size:2.25rem}}@media only all and (min-width:56.25em){.content-header--image .content-header__title.content-header__title--medium{font-size:2.5625rem}}@media only all and (min-width:75em){.content-header--image .content-header__title.content-header__title--medium{font-size:3.25rem}}.content-header--image .content-header__title.content-header__title--long{font-size:1.25rem}@media only all and (min-width:30em){.content-header--image .content-header__title.content-header__title--long{font-size:1.625rem}}@media only all and (min-width:45.625em){.content-header--image .content-header__title.content-header__title--long{font-size:2.25rem}}@media only all and (min-width:75em){.content-header--image .content-header__title.content-header__title--long{font-size:2.5625rem}}.content-header--image .content-header__title.content-header__title--x-long{font-size:1.25rem}@media only all and (min-width:45.625em){.content-header--image .content-header__title.content-header__title--x-long{font-size:1.625rem}}@media only all and (min-width:56.25em){.content-header--image .content-header__title.content-header__title--x-long{font-size:1.625rem}}@media only all and (min-width:75em){.content-header--image .content-header__title.content-header__title--x-long{font-size:1.875rem}}.content-header--image .content-header__title.content-header__title--xx-long{font-size:1.125rem}@media only all and (min-width:30em){.content-header--image .content-header__title.content-header__title--xx-long{font-size:1.25rem}}.content-header__picture{position:absolute;top:0;right:0;bottom:0;left:0;z-index:-1}.content-header__picture:after{content:"";position:absolute;top:0;right:0;bottom:0;left:0;z-index:-1;background-color:rgba(0,0,0,.4)}.content-header__image{z-index:-2;position:absolute;left:50%;top:50%;height:100%;min-width:100%;max-width:none;-ms-transform:translate(-50%,-50%);transform:translate(-50%,-50%)}.content-header__image:after{content:"";background-color:#fff;position:absolute;top:0;left:0;width:100%;height:100%}.content-header__profile_wrapper{padding:18px 0 6px;padding:1.125rem 0 .375rem;font-size:.75rem;line-height:1}.content-header__profile{text-decoration:none}.content-header__profile .content-header__profile_data,.content-header__profile .content-header__profile_label,.content-header__profile dl{display:inline-block;margin:0;font-size:.75rem;line-height:1}@media only all and (min-width:45.625em){.content-header__profile_wrapper{position:absolute;left:0;right:0;line-height:normal}.content-header__profile .content-header__profile_data,.content-header__profile .content-header__profile_label,.content-header__profile dl{display:block;font-size:.6875rem;line-height:2.18182}}.content-header__profile_label{font-size:.875rem;line-height:1.71429;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:400;color:#fff}.content-header__profile_data{font-size:.875rem;line-height:1.71429;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:400;color:#fff}.content-header__profile_image{display:none}@supports (display:flex){@media only all and (min-width:45.625em){.content-header__profile--has-image{display:-ms-inline-flexbox;display:inline-flex;-ms-flex-pack:center;justify-content:center;text-align:left;width:100%}.content-header__profile--has-image .content-header__profile_image{display:block;border-radius:24px;height:48px;width:48px;margin-right:12px;margin-right:.75rem}.content-header__profile--has-image dd,.content-header__profile--has-image dl,.content-header__profile--has-image dt{display:block}.content-header__profile--has-image .content-header__profile_data{color:#fff;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.875rem;line-height:1.71429}.content-header__profile_wrapper{padding:24px 0 0;padding:1.5rem 0 0}}}.content-header__component-assets{display:-ms-grid;display:grid;-ms-grid-columns:50px auto 50px;grid-template-columns:50px auto 50px}.content-header__subject_list{padding-top:24px;padding-top:1.5rem;font-size:.875rem;line-height:1.71429;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:400;color:#087acc;padding-left:0;padding-left:0;padding-right:0;padding-right:0;-ms-grid-row:1;grid-row:1;margin:0;-ms-flex-order:2;order:2;text-align:center}@media only all and (min-width:45.625rem){.content-header__subject_list{padding-left:72px;padding-left:4.5rem;padding-right:72px;padding-right:4.5rem}.content-header-journal .content-header__subject_list{padding-left:0;padding-left:0;padding-right:0;padding-right:0}}.content-header--image .content-header__subject_list{color:inherit}.content-header__subject_list:before{color:#757575}.content-header-journal .content-header__subject_list{padding-top:0;padding-top:0}.content-header__subject_list_item{font-size:.875rem;line-height:1.71429;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:400;color:#087acc;font-size:.8125rem;line-height:1.84615;display:inline;list-style-type:none;padding:0}.content-header__subject_list_item .content-header__subject_link{font-weight:700}.content-header__subject_list_item .content-header__subject_link:after{content:", "}.content-header--image .content-header__subject_list_item{color:inherit}.content-header__subject_list_item:last-child .content-header__subject_link:after{content:""}.content-header__subject_link{font-size:.875rem;line-height:1.71429;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-weight:400;color:#087acc;font-size:.8125rem;line-height:1.84615;text-decoration:none}.content-header-journal .content-header__subject_link{font-size:.875rem;line-height:1.71429}.content-header__subject_link:hover{color:#0769b0;text-decoration:underline;text-underline-offset:3px}.content-header--image .content-header__subject_link{color:inherit}.content-header--image .content-header__subject_link:hover{color:inherit}.content-header__icons{margin:14px 0 0;margin:.875rem 0 0;padding:0;padding:0;-ms-grid-row:1;grid-row:1;list-style:none;-ms-flex-order:1;order:1}.content-header-journal .content-header__icons{margin:0 0 0 6px;margin:0 0 0 .375rem;-ms-flex-order:0;order:0}@media only all and (max-width:29.9375em){.content-header-journal.content-header__has-aside .content-header__icons{margin:0;margin:0}}@media only all and (min-width:75em){.content-header--image .content-header__icons{left:16px}.content-header--image .side-section-wrapper__download_link{right:16px}}.content-header--image .content-header__icons{left:12px;top:12px}.content-header__one-column .content-header__icons{-ms-grid-row:auto;grid-row:auto}.content-header__icon{background-repeat:no-repeat;background-position:left bottom;display:block;height:22px;width:17px}.content-header-journal .content-header__icon{background-position:0 0;height:20px}.content-header__icon--cc{background-image:url(/assets/patterns/img/icons/cc.ec7b6e9c.svg),linear-gradient(transparent,transparent)}.content-header__icon--cc:hover{background-image:url(/assets/patterns/img/icons/cc-hover.7a693c5e.svg),linear-gradient(transparent,transparent)}.content-header-journal .content-header__icon--cc:hover{background-image:url(/assets/patterns/img/icons/cc-new.508bd042.svg)}.content-header-journal .content-header__icon--cc{background-image:url(/assets/patterns/img/icons/cc-new.508bd042.svg)}.content-header__icon--oa{background-image:url(/assets/patterns/img/icons/oa.f53eb8bd.svg),linear-gradient(transparent,transparent)}.content-header__icon--oa:hover{background-image:url(/assets/patterns/img/icons/oa-hover.ec1c5229.svg),linear-gradient(transparent,transparent)}.content-header-journal .content-header__icon--oa:hover{background-image:url(/assets/patterns/img/icons/oa-new.9b599d77.svg)}.content-header-journal .content-header__icon--oa{background-image:url(/assets/patterns/img/icons/oa-new.9b599d77.svg)}.content-header-journal .content-header__icon--cc{width:18px}.content-header-journal .content-header__icon--oa{width:16px}.content-header--image .side-section-wrapper__download_link{right:12px;position:absolute;top:-12px}.content-header__download_icon{width:20px}.side-section .content-header__download_icon{width:20px}.content-header__impact-statement{font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:1rem;line-height:1.5;font-weight:500;margin-bottom:24px;margin-bottom:1.5rem;max-width:100%}.content-header__impact-statement a{border-bottom:1px dotted #212121;color:#212121;text-decoration:none}.content-header__impact-statement a:hover{border-bottom-color:#212121;color:#212121}.content-header__impact-statement a:active,.content-header__impact-statement a:hover{color:inherit}.content-header--image .content-header__impact-statement{margin-bottom:0;margin-bottom:0;display:none}.content-header--image .content-header__impact-statement a{border-bottom:1px dotted #fff;color:#fff;text-decoration:none}.content-header--image .content-header__impact-statement a:hover{border-bottom-color:#fff;color:#fff}@media only all and (min-width:56.25em){.content-header--image .content-header__title.content-header__title--xx-long{font-size:1.625rem}.content-header--image .content-header__impact-statement{display:block}.content-header--image.content-header--has-social-media-sharers .content-header__impact-statement{display:none}}.content-header__cta{margin-bottom:18px;margin-bottom:1.125rem}.content-header--image .content-header__cta{margin-bottom:0;margin-bottom:0;position:absolute;bottom:44px;left:0;right:0}.content-header__meta{padding-bottom:24px;padding-bottom:1.5rem}.content-header--image .content-header__meta{position:absolute;left:0;right:0;bottom:6px;font-size:.75rem;line-height:1}.content-header-journal .content-header--image .content-header__meta{bottom:12px}@media only all and (min-width:45.625em){.content-header--image .side-section-wrapper__download_link{top:0}.content-header__download_icon{width:44px}.content-header--image .content-header__meta{bottom:0;font-size:.75rem;line-height:2}}.content-header-grid__main .content-header__meta{padding-bottom:0;padding-bottom:0}.content-header--image .meta{color:inherit;font-size:.75rem;line-height:1}.content-header--image .date{color:inherit;font-size:.75rem;line-height:1}.content-header--image .meta__type:hover{color:inherit}.content-header__image-credit{color:#757575;font-family:"Noto Sans",Arial,Helvetica,sans-serif;font-size:.6875rem;line-height:2.18182;padding-top:12px;padding-top:.75rem;padding-bottom:12px;padding-bottom:.75rem;text-align:right;visibility:hidden}.content-header__image-credit a,.content-header__image-credit a:hover{color:inherit;text-decoration:underline}.content-header__image-credit--overlay{color:#fff;position:absolute;bottom:0;right:0;padding-right:12px;padding-right:.75rem}.hero-banner{margin-bottom:24px;margin-bottom:1.5rem;background-color:#fff;color:#212121;height:100%;max-width:1114px;width:100%}@media only screen and (min-width:75em){.hero-banner{margin-bottom:48px;margin-bottom:3rem;padding-top:24px;padding-top:1.5rem}}.hero-banner__details .hero-banner__meta .meta{color:inherit;font-size:.875rem;line-height:1}.hero-banner__details .hero-banner__meta .meta__type:hover{color:inherit}.hero-banner__picture-wrapper{height:-webkit-fit-content;height:-moz-fit-content;height:fit-content}.highlight{max-width:1114px;max-width:69.625rem;padding:36px 0;padding:2.25rem 0;border-bottom:1px solid #e0e0e0;margin-left:auto;margin-right:auto;overflow:hidden;position:relative}@media only screen and (min-width:45.625em){.hero-banner{display:-ms-grid;display:grid;grid-auto-flow:dense;-ms-grid-columns:7fr 5fr;grid-template-columns:7fr 5fr}.hero-banner__picture-wrapper{-ms-grid-column:2;grid-column:2}.highlight{padding-bottom:48px;padding-bottom:3rem}}@media only screen and (min-width:75em){.highlight{padding-top:48px;padding-top:3rem}}.highlight__items{list-style:none;margin:0;padding:0}@media only all and (min-width:75em){.content-header--image.content-header--has-social-media-sharers .content-header__impact-statement{display:block}.highlight__items{-ms-flex-align:start;align-items:start;-moz-column-gap:3rem;column-gap:3rem;display:-ms-grid;display:grid;-ms-grid-columns:4fr 4fr 4fr;grid-template-columns:4fr 4fr 4fr}}.listing-list--read-more .content-header-divider{border:none}.listing-list--read-more .content-header--read-more{border:none}.site-header{margin:30px 0;margin:1.875rem 0;max-height:96px;position:relative;z-index:20}@media only screen and (min-width:56.25em){.site-header{margin:42px 0;margin:2.625rem 0}}@media only screen and (min-width:75em){.site-header{margin:54px 0 42px;margin:3.375rem 0 2.625rem}}@supports (display:flex){.site-header{display:-ms-flexbox;display:flex}}.site-header .search-box{background-color:#fff;display:none}.site-header__title{display:inline-block;float:left;position:relative;z-index:21}.site-header__logo_link{background:url(/assets/patterns/img/patterns/molecules/elife-logo-cropped-xs.5f5020c1.svg) no-repeat;display:block;height:35px;width:88px}.site-header__logo_link_image{display:none}@supports (display:flex){.site-header__logo_link{background:0 0}.site-header__logo_link_image{display:block}}.site-header__navigation{background-color:#fff;height:35px;display:-ms-flexbox;display:flex;-ms-flex-pack:right;justify-content:right;margin-left:auto;position:relative;width:100%;z-index:20}.site-header__skip_to_content{display:block;position:absolute;top:20px;left:20px;white-space:nowrap}.site-header__skip_to_content__link{border:0;clip:rect(0 0 0 0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px;padding:15px 36px 14px;padding:.9375rem 2.25rem .875rem;z-index:50}@media only all and (min-width:45.625em){.content-header--image .date{font-size:.75rem;line-height:2}.content-header__image-credit{visibility:visible}.site-header__title{float:left;position:relative;width:88px}.site-header__logo_link{margin:0;margin:0;background:0 0;display:block;float:right;height:35px;position:relative;width:88px;z-index:10}.site-header__logo_link_image{display:block}}@media only screen and (min-width:56.25em){.site-header{max-height:119px}.site-header__navigation{margin-left:20px;margin-left:1.25rem}.site-header__navigation__item{-ms-flex-pack:start;justify-content:flex-start}}@media only screen and (min-width:75em){.site-header{max-height:143px}} </style> <link rel="apple-touch-icon" sizes="57x57" href="/assets/favicons/apple-touch-icon-57x57.c2b7763c.png"> <link rel="apple-touch-icon" sizes="60x60" href="/assets/favicons/apple-touch-icon-60x60.de8ef708.png"> <link rel="apple-touch-icon" sizes="72x72" href="/assets/favicons/apple-touch-icon-72x72.329a975f.png"> <link rel="apple-touch-icon" sizes="76x76" href="/assets/favicons/apple-touch-icon-76x76.bf88533a.png"> <link rel="apple-touch-icon" sizes="114x114" href="/assets/favicons/apple-touch-icon-114x114.1e1b745a.png"> <link rel="apple-touch-icon" sizes="120x120" href="/assets/favicons/apple-touch-icon-120x120.ee3353ac.png"> <link rel="apple-touch-icon" sizes="144x144" href="/assets/favicons/apple-touch-icon-144x144.0a33d19e.png"> <link rel="apple-touch-icon" sizes="152x152" href="/assets/favicons/apple-touch-icon-152x152.8124b596.png"> <link rel="apple-touch-icon" sizes="180x180" href="/assets/favicons/apple-touch-icon-180x180.7dd4e110.png"> <link rel="icon" type="image/svg+xml" href="/assets/favicons/favicon.e086b7f6.svg"> <link rel="icon" type="image/png" sizes="32x32" href="/assets/favicons/favicon-32x32.68f361ed.png"> <link rel="icon" type="image/png" sizes="192x192" href="/assets/favicons/android-chrome-192x192.9d5990c2.png"> <link rel="icon" type="image/png" sizes="16x16" href="/assets/favicons/favicon-16x16.c7965709.png"> <link rel="shortcut icon" href="/assets/favicons/favicon.28c35cbe.ico"> <link rel="manifest" href="/assets/favicons/manifest.dbfa139f.json"> <meta name="theme-color" content="#ffffff"> <meta name="application-name" content="eLife"> <meta name="dc.format" content="text/html"> <meta name="dc.language" content="en"> <meta name="dc.publisher" content="eLife Sciences Publications Limited"> <meta name="dc.title" content="Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants"> <meta name="dc.identifier" content="doi:10.7554/eLife.24307"> <meta name="dc.date" content="2016-12-20"> <meta name="dc.rights" content="© 2016 Sulak et al.. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited."> <meta name="dc.contributor" content="Michael Sulak"> <meta name="dc.contributor" content="Lindsey Fong"> <meta name="dc.contributor" content="Katelyn Mika"> <meta name="dc.contributor" content="Sravanthi Chigurupati"> <meta name="dc.contributor" content="Lisa Yon"> <meta name="dc.contributor" content="Nigel P Mongan"> <meta name="dc.contributor" content="Richard D Emes"> <meta name="dc.contributor" content="Vincent J Lynch"> <meta property="og:site_name" content="eLife"> <meta property="og:url" content="https://elifesciences.org/articles/24307"> <meta property="og:title" content="Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants"> <meta name="twitter:site" content="@eLife"> <meta property="og:description" content=""> <meta name="description" content=""> <meta name="twitter:card" content="summary"> <meta name="twitter:image" content="https://elifesciences.org/assets/images/social/icon-600x600@1.52e87ee6.png"> <meta property="og:image" content="https://elifesciences.org/assets/images/social/icon-600x600@1.52e87ee6.png"> <meta property="og:image:width" content="600"> <meta property="og:image:height" content="600"> <meta property="og:type" content="article"> <link rel="canonical" href="/articles/24307"> <script type="text/plain" data-cookieconsent="statistics,marketing"> window.gtmDataLayer = window.gtmDataLayer || []; window.gtmDataLayer.push( { 'articleSubjects': 'Cell Biology, Evolutionary Biology', 'articleType': 'Correction', 'articlePublishDate': 'Dec 20, 2016' } ); (function (w, d, s, l, i) { w[l] = w[l] || []; w[l].push({ 'gtm.start': new Date().getTime(), event: 'gtm.js' }); var f = d.getElementsByTagName(s)[0], j = d.createElement(s), dl = l != 'dataLayer' ? '&l=' + l : ''; j.async = true; j.src = 'https://www.googletagmanager.com/gtm.js?id=' + i + dl; f.parentNode.insertBefore(j, f); })(window, document, 'script', 'gtmDataLayer', 'GTM-WVM8KG'); </script> <script type="text/plain" data-cookieconsent="statistics" src="https://www.googleoptimize.com/optimize.js?id=OPT-KJGKNCT"></script> </head> <body> <noscript> <iframe src="https://www.googletagmanager.com/ns.html?id=GTM-WVM8KG" height="0" width="0" style="display:none; visibility:hidden"></iframe> </noscript> <div class="global-wrapper" data-behaviour="FragmentHandler Math HypothesisLoader" data-item-type="correction" > <div class="global-inner"> <div class="wrapper wrapper--site-header"> <header class="site-header clearfix" data-behaviour="SiteHeader" id="siteHeader"> <div class="site-header__title clearfix" role="banner"> <div class="site-header__skip_to_content"> <a href="#maincontent" class="site-header__skip_to_content__link button button--default">Skip to Content</a> </div> <a href="/" class="site-header__logo_link"> <picture class="site-header__logo_link_image"> <source srcset="/assets/patterns/img/patterns/organisms/elife-logo-xs.fd623d00.svg" type="image/svg+xml"> <img src="/assets/patterns/img/patterns/organisms/elife-logo-xs@1x.f9b97bde.png" alt="eLife logo" class="site-header__logo_link"/> </picture> <span class="visuallyhidden" >eLife home page</span> </a> </div> <div class="site-header__navigation" role="navigation" aria-label="Main navigation"> <div class="site-header__navigation__item"> <nav class="nav-primary"> <ul class="nav-primary__list clearfix"> <li class="nav-primary__item nav-primary__item--first"> <a href="#mainMenu"> Menu </a> </li> <li class="nav-primary__item"> <a href="/"> Home </a> </li> <li class="nav-primary__item"> <a href="/magazine"> Magazine </a> </li> <li class="nav-primary__item"> <a href="/community"> Community </a> </li> <li class="nav-primary__item nav-primary__item--last"> <a href="/about"> About </a> </li> </ul> </nav> </div> <nav class="nav-secondary"> <ul class="nav-secondary__list clearfix"> <li class="nav-secondary__item nav-secondary__item--first nav-secondary__item--search"> <a href="/search" rel="search"> Search </a> </li> <li class="nav-secondary__item nav-secondary__item--alert"> <a href="/content-alerts"> Alerts </a> </li> <li class="nav-secondary__item nav-secondary__item--last nav-secondary__item--hide-narrow"> <a href="/submit-your-research" class="button button--extra-small button--default" id="submitResearchButton">Submit your research</a> </li> </ul> </nav> </div> <div class="search-box" data-behaviour="SearchBox"> <div class="search-box__inner"> <form class="compact-form" id="search" action="/search" method="GET" novalidate> <fieldset class="compact-form__container"> <label> <span class="visuallyhidden">Search by keyword or author</span> <input type="search" name="for" value="" placeholder="Search by keyword or author" class="compact-form__input" > </label> <button type="reset" name="reset" class="compact-form__reset"><span class="visuallyhidden">Reset form</span></button> <button type="submit" class="compact-form__submit"><span class="visuallyhidden">Search</span></button> </fieldset> </form> <label class="search-box__search_option_label"> <input type="checkbox" name="subjects[]" value="cell-biology" form="search">Limit my search to Cell Biology </label> </div> </div> </header> </div> <div class="info-bar info-bar--correction" > <div class="info-bar__container"> <div class="info-bar__text">This is a correction notice. Read the <a href="/articles/11994">corrected article</a>.</div> </div> </div> <main role="main" class="main" id="maincontent"> <div class="wrapper wrapper--content-with-header-and-aside"> <header class="content-header content-header-journal wrapper content-header--header content-header--has-social-media-sharers content-header__has-aside" data-behaviour="ContentHeader"> <div class="content-container-grid"> <div class="content-header-grid-top"> <ul class="breadcrumbs"> <li class="breadcrumb-item"> <a href="/articles/correction" class="breadcrumb-item__link">Correction</a> </li> </ul> <ol class="content-header__subject_list"> <li class="content-header__subject_list_item"> <a href="/subjects/cell-biology" class="content-header__subject_link">Cell Biology</a> </li> <li class="content-header__subject_list_item"> <a href="/subjects/evolutionary-biology" class="content-header__subject_link">Evolutionary Biology</a> </li> </ol> </div> <div class="content-header-grid__main"> <div class="content-header__body"> <h1 class="content-header__title content-header__title--xx-long">Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants</h1> </div> <div class="authors" data-behaviour="Authors"> <ol class="author_list" aria-label="Authors of this article"> <li class="author_list_item"><span class="author"><a href="/articles/24307#xb42580c6" data-behaviour="Popup" class="author_link">Michael Sulak</a></span></li><li class="author_list_item"><span class="author"><a href="/articles/24307#x8c100906" data-behaviour="Popup" class="author_link">Lindsey Fong</a></span></li><li class="author_list_item"><span class="author"><a href="/articles/24307#xdb7bc2b9" data-behaviour="Popup" class="author_link">Katelyn Mika</a></span></li><li class="author_list_item"><span class="author"><a href="/articles/24307#xd92b8b4d" data-behaviour="Popup" class="author_link">Sravanthi Chigurupati</a></span></li><li class="author_list_item"><span class="author"><a href="/articles/24307#xfd0f535b" data-behaviour="Popup" class="author_link">Lisa Yon</a></span></li><li class="author_list_item"><span class="author"><a href="/articles/24307#x54740d81" data-behaviour="Popup" class="author_link">Nigel P Mongan</a></span></li><li class="author_list_item"><span class="author"><a href="/articles/24307#x24750cbb" data-behaviour="Popup" class="author_link">Richard D Emes</a></span></li><li class="author_list_item"><span class="author"><a href="/articles/24307#x6f449d78" data-behaviour="Popup" class="author_link">Vincent J Lynch</a></span></li> </ol> </div> <div class="content-header__footer"> <div class="content-header__meta"> <div class="meta"> <span class="date"> <time datetime="2016-12-20">Dec 20, 2016</time></span> </div> </div> <span class="doi"> <a href="https://doi.org/10.7554/eLife.24307" class="doi__link"> https://doi.org/10.7554/eLife.24307 </a> </span> <ul class="content-header__icons"> <li> <a href="https://en.wikipedia.org/wiki/Open_access" class="content-header__icon content-header__icon--oa"> <span class="visuallyhidden">Open access</span> </a> </li> <li> <a href="#copyright" class="content-header__icon content-header__icon--cc"> <span class="visuallyhidden">Copyright information</span> </a> </li> </ul> </div> </div> <div class="divider"></div> </div> </header> <aside class="content-aside" data-behaviour="ContentAside"> <div class="content-aside__column-wrapper"> <div class="content-aside__second-column"> <ol class="button-collection button-collection--inline"> <li class="button-collection__item"> <a href="#downloads" class="button button--default button--action icon icon-download" id="button-action-download">Download</a> </li> <li class="button-collection__item"> <a href="#cite-this-article" class="button button--default button--action icon icon-citation" id="modalContentCitations">Cite</a> </li> <li class="button-collection__item"> <a href="#share" class="button button--default button--action icon icon-share" id="modalContentShare">Share</a> </li> <li class="button-collection__item"><div data-hypothesis-trigger> <a href="#comment" class="button button--default button--action icon icon-comment" data-behaviour="HypothesisTrigger">Comment<span aria-hidden='true'><span data-visible-annotation-count></span> </span><span class='visuallyhidden'>Open annotations (there are currently <span data-hypothesis-annotation-count>0</span> annotations on this page). </span></a> </div> </li> </ol> <div class="contextual-data"> <ul class="contextual-data__list" aria-label="The following contains the number of views, citations and annotations in this article"> <li class="contextual-data__item"><a href="/articles/24307#metrics"><span class="contextual-data__counter">1,042</span> views</a></li> <li class="contextual-data__item"><a href="/articles/24307#metrics"><span class="contextual-data__counter">16</span> citations</a></li> </ul> </div> </div> </div> </aside> <div class="modal modal-nojs" data-behaviour="Modal" data-trigger-id="modalContentShare"> <div class="modal-container"> <div class="modal-content"> <h6>Share this article</h6> <a href="" class="modal-content__button modal-content__close-button"></a> <div class="modal-content__body"> <div class="form-item"> <div class="form-item__label_container"> <label for="modal-share-doi" class="form-item__label visuallyhidden"> Doi </label> </div> <input type="text" class="text-field text-field--text" id="modal-share-doi" name="doi" value="https://doi.org/10.7554/eLife.24307" > </div> <button class="button button--default" type="button" data-behaviour="ButtonClipboard" data-clipboard="https://doi.org/10.7554/eLife.24307">Copy to clipboard</button> <ul class="social-media-sharers"> <li> <a class="social-media-sharer email" href="mailto:?subject=Correction%3A%20TP53%20copy%20number%20expansion%20is%20associated%20with%20the%20evolution%20of%20increased%20body%20size%20and%20an%20enhanced%20DNA%20damage%20response%20in%20elephants&body=https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_blank" rel="noopener noreferrer" aria-label="Share by Email"> <svg width="24px" height="24px" viewBox="0 0 24 24" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g id="email" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <rect id="clear-button-bg" x="0" y="0" width="24" height="24"></rect> <path d="M20,4 L4,4 C2.9,4 2.01,4.9 2.01,6 L2,18 C2,19.1 2.9,20 4,20 L20,20 C21.1,20 22,19.1 22,18 L22,6 C22,4.9 21.1,4 20,4 Z M20,8 L12,13 L4,8 L4,6 L12,11 L20,6 L20,8 Z" id="Shape" fill="#000000" fill-rule="nonzero"></path> </g> </svg> </a> </li> <li> <a class="social-media-sharer" href="https://twitter.com/intent/tweet/?text=In%20%40eLife%3A%20Correction%3A%20TP53%20copy%20number%20expansion%20is%20associated%20with%20the%20evolution%20of%20increased%20body%20size%20and%20an%20enhanced%20DNA%20damage%20response%20in%20elephants&url=https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_blank" rel="noopener noreferrer" aria-label="Tweet a link to this page"> <svg width="24px" height="24px" viewBox="0 0 24 24" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g id="x-24-articles" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <rect id="Rectangle" x="0" y="0" width="24" height="24"></rect> <path d="M13.6604555,11.4785798 L20.954365,3 L19.225942,3 L12.8926412,10.3618317 L7.83425247,3 L2,3 L9.64927632,14.1323934 L2,23.023486 L3.72852106,23.023486 L10.4166498,15.2491415 L15.7586789,23.023486 L21.5929313,23.023486 L13.660031,11.4785798 L13.6604555,11.4785798 Z M11.293009,14.2304723 L10.5179779,13.1219369 L4.35133136,4.30120576 L7.00623887,4.30120576 L11.9827944,11.4198173 L12.7578255,12.5283527 L19.2267583,21.7814574 L16.5718508,21.7814574 L11.293009,14.2308968 L11.293009,14.2304723 Z" id="Shape" fill="#212121" fill-rule="nonzero"></path> </g> </svg> </a> </li> <li> <a class="social-media-sharer" href="https://facebook.com/sharer/sharer.php?u=https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_blank" rel="noopener noreferrer" aria-label="Share on Facebook"> <svg width="24px" height="24px" viewBox="0 0 24 24" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g id="facebook" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g> <rect id="clear-button-bg" x="0" y="0" width="24" height="24"></rect> <path d="M11.8969072,2 C6.43099227,2 2,6.41067993 2,11.8515383 C2,16.7687258 5.61915593,20.844338 10.3505155,21.5833958 L10.3505155,14.6992486 L7.83762887,14.6992486 L7.83762887,11.8515383 L10.3505155,11.8515383 L10.3505155,9.68112126 C10.3505155,7.21207948 11.8280541,5.84825714 14.0887242,5.84825714 C15.1715271,5.84825714 16.3041237,6.04067 16.3041237,6.04067 L16.3041237,8.465072 L15.0561469,8.465072 C13.8267075,8.465072 13.443299,9.22446783 13.443299,10.0035475 L13.443299,11.8515383 L16.1881443,11.8515383 L15.7493557,14.6992486 L13.443299,14.6992486 L13.443299,21.5833958 C18.1746585,20.844338 21.7938144,16.7687258 21.7938144,11.8515383 C21.7938144,6.41067993 17.3628222,2 11.8969072,2 Z" id="Fill-1" fill="#212121" fill-rule="nonzero"></path> </g> </g> </svg> </a> </li> <li> <a class="social-media-sharer" href="https://www.linkedin.com/shareArticle?title=Correction%3A%20TP53%20copy%20number%20expansion%20is%20associated%20with%20the%20evolution%20of%20increased%20body%20size%20and%20an%20enhanced%20DNA%20damage%20response%20in%20elephants&url=https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_self" aria-label="Share this page to LinkedIn (opens up email program, if configured on this system)"> <svg width="24px" height="24px" viewBox="0 0 24 24" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g id="linkedin" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g> <rect id="Rectangle" x="0" y="0" width="24" height="24"></rect> <path d="M18.9751954,18.9751435 L16.0232549,18.9751435 L16.0232549,14.3522816 C16.0232549,13.2499163 16.0035753,11.8308324 14.4879383,11.8308324 C12.9504693,11.8308324 12.7152366,13.0319032 12.7152366,14.2720257 L12.7152366,18.974836 L9.76329605,18.974836 L9.76329605,9.46835755 L12.5971589,9.46835755 L12.5971589,10.7675189 L12.6368256,10.7675189 C13.2146663,9.77952684 14.2890899,9.18943873 15.4328668,9.23189481 C18.4247815,9.23189481 18.9764254,11.1998552 18.9764254,13.7600486 L18.9751954,18.9751435 Z M6.43252317,8.16888879 C5.48643292,8.16905854 4.71933758,7.40223852 4.7191677,6.45614827 C4.71899794,5.51005802 5.48581795,4.74296266 6.4319082,4.74279278 C7.37799845,4.74262301 8.14509382,5.50944301 8.14526371,6.45553326 C8.14534522,6.90986184 7.96494211,7.34561469 7.64374096,7.66693118 C7.32253981,7.98824766 6.88685175,8.16880719 6.43252317,8.16888879 M7.90849343,18.9751435 L4.95347798,18.9751435 L4.95347798,9.46835755 L7.90849343,9.46835755 L7.90849343,18.9751435 Z M20.4468607,2.00148552 L3.47012787,2.00148552 C2.66777241,1.99243094 2.00979231,2.63513479 2,3.43748159 L2,20.4846305 C2.00945705,21.2873639 2.6673842,21.9307041 3.47012787,21.9223954 L20.4468607,21.9223954 C21.2511925,21.9322515 21.9116962,21.2889485 21.922831,20.4846305 L21.922831,3.43625161 C21.9113617,2.63231978 21.2508045,1.98965267 20.4468607,2" id="Path_2520" fill="#212121" fill-rule="nonzero"></path> </g> </g> </svg> </a> </li> <li> <a class="social-media-sharer" href="https://reddit.com/submit/?title=Correction%3A%20TP53%20copy%20number%20expansion%20is%20associated%20with%20the%20evolution%20of%20increased%20body%20size%20and%20an%20enhanced%20DNA%20damage%20response%20in%20elephants&url=https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_blank" rel="noopener noreferrer" aria-label="Share this page on Reddit"> <svg width="24px" height="24px" viewBox="0 0 24 24" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g id="reddit" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g> <rect id="Rectangle" x="0" y="0" width="24" height="24"></rect> <path d="M11.9872095,1.051163 C18.0270212,1.051163 22.923256,5.94739779 22.923256,11.9872095 C22.923256,18.0270212 18.0270212,22.923256 11.9872095,22.923256 C5.94739779,22.923256 1.051163,18.0270212 1.051163,11.9872095 C1.051163,5.94739779 5.94739779,1.051163 11.9872095,1.051163 Z M16.5534886,5.37441881 C16.1058142,5.37441881 15.7220932,5.63023277 15.5430235,6.0139537 L12.895349,5.451163 C12.8186049,5.4383723 12.7418607,5.451163 12.6779072,5.48953509 C12.6139537,5.52790719 12.5755816,5.59186067 12.5500002,5.66860486 L11.7441863,9.48023277 C10.0430235,9.53139556 8.52093044,10.0302328 7.42093044,10.8360467 C7.13953509,10.5674421 6.74302347,10.3883723 6.32093044,10.3883723 C5.4383723,10.3883723 4.72209323,11.1046514 4.72209323,11.9872095 C4.72209323,12.6395351 5.10581416,13.1895351 5.66860486,13.445349 C5.64302347,13.5988374 5.63023277,13.7651165 5.63023277,13.9313956 C5.63023277,16.3872095 8.48255835,18.3697677 12.0127909,18.3697677 C15.5430235,18.3697677 18.395349,16.3872095 18.395349,13.9313956 C18.395349,13.7651165 18.3825583,13.6116281 18.356977,13.4581397 C18.8813956,13.2023258 19.2779072,12.6395351 19.2779072,11.9872095 C19.2779072,11.1046514 18.5616281,10.3883723 17.67907,10.3883723 C17.2441863,10.3883723 16.8604653,10.5546514 16.57907,10.8360467 C15.4918607,10.0558142 13.9825583,9.54418626 12.3197677,9.48023277 L13.0488374,6.06511649 L15.4151165,6.5639537 C15.4406979,7.16511649 15.9395351,7.651163 16.5534886,7.651163 C17.1802328,7.651163 17.6918607,7.13953509 17.6918607,6.51279091 C17.6918607,5.88604672 17.1802328,5.37441881 16.5534886,5.37441881 Z M9.72325602,15.7093025 C10.2093025,16.195349 11.2581397,16.3744188 12.0127909,16.3744188 C12.7674421,16.3744188 13.8034886,16.195349 14.3023258,15.7093025 C14.4174421,15.5941863 14.6093025,15.5941863 14.7244188,15.7093025 C14.8139537,15.8372095 14.8139537,16.0162793 14.6988374,16.1313956 C13.9186049,16.9116281 12.4348839,16.9627909 12.0000002,16.9627909 C11.5651165,16.9627909 10.0686049,16.8988374 9.301163,16.1313956 C9.18604672,16.0162793 9.18604672,15.8244188 9.301163,15.7093025 C9.41627928,15.5941863 9.60813974,15.5941863 9.72325602,15.7093025 Z M9.48023277,11.9872095 C10.1069769,11.9872095 10.6186049,12.4988374 10.6186049,13.1255816 C10.6186049,13.7523258 10.1069769,14.2639537 9.48023277,14.2639537 C8.85348858,14.2639537 8.34186067,13.7523258 8.34186067,13.1255816 C8.34186067,12.4988374 8.85348858,11.9872095 9.48023277,11.9872095 Z M14.4941863,11.9872095 C15.1209304,11.9872095 15.6325583,12.4988374 15.6325583,13.1255816 C15.6325583,13.7523258 15.1209304,14.2639537 14.4941863,14.2639537 C13.8674421,14.2639537 13.3558142,13.7523258 13.3558142,13.1255816 C13.3558142,12.4988374 13.8674421,11.9872095 14.4941863,11.9872095 Z" id="Combined-Shape" fill="#212121" fill-rule="nonzero"></path> </g> </g> </svg> </a> </li> <li> <a class="social-media-sharer" href="https://toot.kytta.dev/?text=Correction%3A%20TP53%20copy%20number%20expansion%20is%20associated%20with%20the%20evolution%20of%20increased%20body%20size%20and%20an%20enhanced%20DNA%20damage%20response%20in%20elephants%20https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_blank" rel="noopener noreferrer" aria-label="Share this page on Mastodon"> <svg width="24px" height="24px"> <g id="mastodon" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g> <rect id="Rectangle" x="0" y="0" width="24" height="24"></rect> <path d='M11.5412949,0 C14.6936837,0.0250851513 17.7279692,0.357269448 19.4950021,1.1471931 C19.4950021,1.1471931 22.9995752,2.67324958 22.9995752,7.87958222 L23,8.27840764 C22.9948717,9.32900538 22.9399626,12.2394095 22.5108214,14.3877566 C22.1727192,16.0807457 19.4826471,17.9335557 16.3930961,18.2926354 C14.7820287,18.4797396 13.1958041,18.6517151 11.5043627,18.5762011 C8.73816776,18.4528442 6.55544838,17.9335557 6.55544838,17.9335557 C6.55544838,18.1956567 6.57205459,18.4452152 6.605267,18.6786105 C6.96489093,21.335697 9.312211,21.4948713 11.5357152,21.5690923 C13.7799439,21.6438306 15.7782681,21.0305374 15.7782681,21.0305374 L15.8704657,23.0052819 C15.8704657,23.0052819 14.3007146,23.8257215 11.5043627,23.9766203 C9.96237703,24.0591169 8.04774824,23.9388633 5.8177344,23.3643616 C0.981210876,22.1183796 0.149439349,17.1004442 0.022169409,12.0089343 C-0.0166226796,10.4972307 0.00729025582,9.07177343 0.00729025582,7.87958222 C0.00729025582,2.67324958 3.51199627,1.1471931 3.51199627,1.1471931 C5.27916201,0.357269448 8.31145476,0.0250851513 11.4638436,0 L11.5412949,0 Z M15.8599153,5 C14.461897,5 13.4033065,5.46697151 12.7035195,6.40103745 L12.0229667,7.39238391 L11.3425554,6.40103745 C10.642627,5.46697151 9.58403654,5 8.18615964,5 C6.97793807,5 6.00462882,5.36912752 5.26142334,6.08919046 C4.54070495,6.8092534 4.18190148,7.78253068 4.18190148,9.00730143 L4.18190148,15 L6.91358821,15 L6.91358821,9.1834452 C6.91358821,7.95732233 7.50716259,7.33498047 8.69445278,7.33498047 C10.0071899,7.33498047 10.6652556,8.0732355 10.6652556,9.5330285 L10.6652556,12.7167687 L13.3808194,12.7167687 L13.3808194,9.5330285 C13.3808194,8.0732355 14.0387436,7.33498047 15.3514807,7.33498047 C16.5387709,7.33498047 17.1323453,7.95732233 17.1323453,9.1834452 L17.1323453,15 L19.864032,15 L19.864032,9.00730143 C19.864032,7.78253068 19.5052285,6.8092534 18.7846516,6.08919046 C18.0413047,5.36912752 17.0679954,5 15.8599153,5 Z' id='Combined-Shape' fill='#212121' fill-rule='nonzero'></path> </g> </g> </svg> </a> </li> </ul> </div> </div> </div> </div> <div class="modal modal-nojs" data-behaviour="Modal" data-trigger-id="modalContentCitations"> <div class="modal-container"> <div class="modal-content"> <h6>Cite this article</h6> <a href="" class="modal-content__button modal-content__close-button"></a> <div class="modal-content__body"> <div class="reference"> <ol class="reference__authors_list"> <li class="reference__author"> Michael Sulak</li> <li class="reference__author"> Lindsey Fong</li> <li class="reference__author"> Katelyn Mika</li> <li class="reference__author"> Sravanthi Chigurupati</li> <li class="reference__author"> Lisa Yon</li> <li class="reference__author"> Nigel P Mongan</li> <li class="reference__author"> Richard D Emes</li> <li class="reference__author"> Vincent J Lynch</li> </ol> <span class="reference__authors_list_suffix">(2016)</span> <div class="reference__title">Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants</div> <div class="reference__origin"><i>eLife</i> <b>5</b>:e24307.</div> <div class="doi__reference-spacing"></div> <span class="doi"> https://doi.org/10.7554/eLife.24307 </span> </div> <ol class="button-collection"> <li class="button-collection__item"> <button class="button button--default" type="button" data-behaviour="ButtonClipboard" data-clipboard="Michael Sulak, Lindsey Fong, Katelyn Mika, Sravanthi Chigurupati, Lisa Yon, Nigel P Mongan, Richard D Emes, Vincent J Lynch (2016) Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants eLife 5:e24307 https://doi.org/ ">Copy to clipboard</button> </li> <li class="button-collection__item"> <a href="/articles/24307.bib" class="button button--secondary">Download BibTeX</a> </li> <li class="button-collection__item"> <a href="/articles/24307.ris" class="button button--secondary">Download .RIS</a> </li> </ol> </div> </div> </div> </div> <div data-behaviour="DelegateBehaviour" data-delegate-behaviour="Popup" data-selector=".article-section:not(#abstract) a" class="wrapper wrapper--content" id="content"> <div class="content-container-grid"> <nav class="tabbed-navigation" data-behaviour="TabbedNavigation"> <ul class="tabbed-navigation__tabs"> <li class="tabbed-navigation__tab-label tabbed-navigation__tab-label--active"> <a href="/articles/24307#content">Full text</a> </li> <li class="tabbed-navigation__tab-label tabbed-navigation__tab-label--side-by-side" data-side-by-side-link="https://lens.elifesciences.org/24307"> <a href="https://lens.elifesciences.org/24307">Side by side</a> </li> </ul> </nav> <div class="jump-menu__wrapper" data-behaviour="JumpMenu"> <ul class="jump-menu__list"> <li class="jump-menu__item"> <a href="#s0" class="jump-menu">Main text</a> </li> <li class="jump-menu__item"> <a href="#info" class="jump-menu">Article and author information</a> </li> <li class="jump-menu__item"> <a href="#metrics" class="jump-menu">Metrics</a> </li> </ul> </div> <div class="main-content-grid"> <section class="article-section article-section--first" id="s0" data-behaviour="ArticleSection" > <header class="article-section__header"> <h2 class="article-section__header_text">Main text</h2> </header> <div class="article-section__body"> <p class="paragraph">Sulak M, Fong L, Mika K, Chigurupati S, Yon L, Mongan NP, Emes RD, Lynch VJ. 2016. <i>TP53</i> copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. <i>eLife</i> <b>5</b>:e11994. doi: <a href="http://dx.doi.org/10.7554/eLife.11994">10.7554/eLife.11994</a>.</p> <p class="paragraph">Published 19, September 2016</p> <p class="paragraph">After publication we became aware of three incorrect citations in the Materials and methods.</p> <p class="paragraph">The Notung v2.6 citation was incorrectly cited as Notung v2.6 (Wilkie et al., 2013) and Notung v2.6 (Trapnell et al., 2012), it should have cited Chen et al. 2000.</p> <p class="paragraph">The Proboscidean body size citation was incorrectly cited as ‘Proboscidean body size data were obtained from previously published studies on mammalian body size evolution (Chen et al., 2000)’, it should have cited Evans et al. 2012.</p> <p class="paragraph">The article has been corrected accordingly.</p> </div> </section> <button class="speech-bubble speech-bubble--has-placeholder speech-bubble--wrapped " data-behaviour="SpeechBubble HypothesisOpener" aria-live="polite"> <span class="speech-bubble--wrapped__prefix">Add a comment</span> <span class="speech-bubble__inner"><span aria-hidden="true"><span data-visible-annotation-count>+</span></span><span class="visuallyhidden"> Open annotations. The current annotation count on this page is <span data-hypothesis-annotation-count>being calculated</span>.</span></span> </button> <section class="article-section " id="info" data-behaviour="ArticleSection" data-initial-state="closed" > <header class="article-section__header"> <h2 class="article-section__header_text">Article and author information</h2> </header> <div class="article-section__body"> <h3 class="authors-details__heading">Author details</h3> <ol class="authors-details__authors"> <li class="authors-details__author"><div class="author-details" data-popup-contents="xb42580c6" id="xb42580c6"> <h4 class="author-details__name">Michael Sulak</h4> </div> </li> <li class="authors-details__author"><div class="author-details" data-popup-contents="x8c100906" id="x8c100906"> <h4 class="author-details__name">Lindsey Fong</h4> </div> </li> <li class="authors-details__author"><div class="author-details" data-popup-contents="xdb7bc2b9" id="xdb7bc2b9"> <h4 class="author-details__name">Katelyn Mika</h4> </div> </li> <li class="authors-details__author"><div class="author-details" data-popup-contents="xd92b8b4d" id="xd92b8b4d"> <h4 class="author-details__name">Sravanthi Chigurupati</h4> </div> </li> <li class="authors-details__author"><div class="author-details" data-popup-contents="xfd0f535b" id="xfd0f535b"> <h4 class="author-details__name">Lisa Yon</h4> </div> </li> <li class="authors-details__author"><div class="author-details" data-popup-contents="x54740d81" id="x54740d81"> <h4 class="author-details__name">Nigel P Mongan</h4> </div> </li> <li class="authors-details__author"><div class="author-details" data-popup-contents="x24750cbb" id="x24750cbb"> <h4 class="author-details__name">Richard D Emes</h4> </div> </li> <li class="authors-details__author"><div class="author-details" data-popup-contents="x6f449d78" id="x6f449d78"> <h4 class="author-details__name">Vincent J Lynch</h4> <section class="author-details__section"> <span class="orcid"> <a href="https://orcid.org/0000-0001-5311-3824"> <picture> <source srcset="/assets/patterns/img/icons/orcid.b96370b9.svg" type="image/svg+xml"> <img src="/assets/patterns/img/icons/orcid.e0a7f9de.png" class="orcid__icon" alt="ORCID icon"> </picture> <span class="visuallyhidden">"This ORCID iD identifies the author of this article:"</span> 0000-0001-5311-3824</a> </span> </section> </div> </li> </ol> <section class="article-section " > <header class="article-section__header"> <h3 class="article-section__header_text">Version history</h3> </header> <div class="article-section__body"> <ol class="list list--bullet"> <li>Received: <time datetime="December 15, 2016">December 15, 2016</time></li> <li>Accepted: <time datetime="December 15, 2016">December 15, 2016</time></li> <li><a href="/articles/24307">Version of Record published</a>: <time datetime="2016-12-20">December 20, 2016</time></li> </ol> </div> </section> <section class="article-section " id="copyright" > <header class="article-section__header"> <h3 class="article-section__header_text">Copyright</h3> </header> <div class="article-section__body"> <p>© 2016, Sulak et al.</p><p>This article is distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</a>, which permits unrestricted use and redistribution provided that the original author and source are credited.</p> </div> </section> </div> </section> <section class="article-section " id="metrics" data-behaviour="ArticleSection" data-initial-state="closed" > <header class="article-section__header"> <h2 class="article-section__header_text">Metrics</h2> </header> <div class="article-section__body"> <ul class="statistic-collection clearfix" data-behaviour="StatisticCollection"> <li class="statistic-collection__item"> <dl class="statistic"> <dd class="statistic__value"> 1,042 </dd> <dt class="statistic__label"> views </dt> </dl> </li> <li class="statistic-collection__item"> <dl class="statistic"> <dd class="statistic__value"> 16 </dd> <dt class="statistic__label"> citations </dt> </dl> </li> </ul> <p class="paragraph">Views, downloads and citations are aggregated across all versions of this paper published by eLife.</p> <div data-behaviour="Metrics" data-id="24307" data-type="article" data-container-id="page-views" data-metric="page-views" data-period="month" data-api-endpoint="https://api.elifesciences.org" data-chevron-left-svg="/assets/patterns/img/patterns/molecules/chevron-left-ic.5a64c74f.svg" data-chevron-left-srcset="/assets/patterns/img/patterns/molecules/chevron-left-ic_2x.6b3ada52.png 48w, /assets/patterns/img/patterns/molecules/chevron-left-ic_1x.1e8d2a3f.png 24w" data-chevron-left-src="/assets/patterns/img/patterns/molecules/chevron-left-ic_1x.1e8d2a3f.png" data-chevron-right-svg="/assets/patterns/img/patterns/molecules/chevron-right-ic.b299caa7.svg" data-chevron-right-srcset="/assets/patterns/img/patterns/molecules/chevron-right-ic_2x.f14c9491.png 48w, /assets/patterns/img/patterns/molecules/chevron-right-ic_1x.d24da5fc.png 24w" data-chevron-right-src="/assets/patterns/img/patterns/molecules/chevron-right-ic_1x.d24da5fc.png" aria-hidden="true" > </div> </div> </section> <section class="article-section " > <header class="article-section__header"> <h2 class="article-section__header_text">Download links</h2> </header> <div class="article-section__body"> <div data-behaviour="ArticleDownloadLinksList" id="downloads" aria-labelledby="downloads-label"> <div class="visuallyhidden"><span id="downloads-label">A two-part list of links to download the article, or parts of the article, in various formats.</span></div> <div class="article-download-links-list__group"> <h3 class="article-download-links-list__heading" id="downloads">Open citations<span class="visuallyhidden"> (links to open the citations from this article in various online reference manager services)</span></h3> <ul class="article-download-list"> <li class="article-download-links-list__item"> <a href="https://www.mendeley.com/import?doi=10.7554/eLife.24307" class="article-download-links-list__link" >Mendeley</a> </li> <li class="article-download-links-list__item"> <span data-behaviour="CheckPMC" data-check-available="https://ncbi.nlm.nih.gov/pmc/utils/idconv/v1.0/?ids=10.7554/eLife.24307&format=json" data-display-on-available="<a href='' class='article-download-links-list__link'></a>"></span> </li> </ul> </div> <div class="article-download-links-list__group article-download-links-list__group--js-exclude"> <h3 class="article-download-links-list__heading" id="cite-this-article">Cite this article<span class="visuallyhidden"> (links to download the citations from this article in formats compatible with various reference manager tools)</span></h3> <div class="article-download-links-list__intro"><div class="reference"> <ol class="reference__authors_list"> <li class="reference__author"> Michael Sulak</li> <li class="reference__author"> Lindsey Fong</li> <li class="reference__author"> Katelyn Mika</li> <li class="reference__author"> Sravanthi Chigurupati</li> <li class="reference__author"> Lisa Yon</li> <li class="reference__author"> Nigel P Mongan</li> <li class="reference__author"> Richard D Emes</li> <li class="reference__author"> Vincent J Lynch</li> </ol> <span class="reference__authors_list_suffix">(2016)</span> <div class="reference__title">Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants</div> <div class="reference__origin"><i>eLife</i> <b>5</b>:e24307.</div> <div class="doi__reference-spacing"></div> <span class="doi"> https://doi.org/10.7554/eLife.24307 </span> </div> </div> <ul class="article-download-list"> <li class="article-download-links-list__item"> <a href="/articles/24307.bib" class="article-download-links-list__link" >Download BibTeX</a> </li> <li class="article-download-links-list__item"> <a href="/articles/24307.ris" class="article-download-links-list__link" >Download .RIS</a> </li> </ul> </div> </div> </div> </section> <section class="article-section article-section__sharers " id="share" > <header class="article-section__header"> <h3 class="article-section__header_text">Share this article</h3> </header> <div class="article-section__body"> <span class="doi"> <a href="https://doi.org/10.7554/eLife.24307" class="doi__link"> https://doi.org/10.7554/eLife.24307 </a> </span> <ul class="social-media-sharers"> <li> <a class="social-media-sharer email" href="mailto:?subject=Correction%3A%20TP53%20copy%20number%20expansion%20is%20associated%20with%20the%20evolution%20of%20increased%20body%20size%20and%20an%20enhanced%20DNA%20damage%20response%20in%20elephants&body=https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_blank" rel="noopener noreferrer" aria-label="Share by Email"> <svg width="24px" height="24px" viewBox="0 0 24 24" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g id="email" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <rect id="clear-button-bg" x="0" y="0" width="24" height="24"></rect> <path d="M20,4 L4,4 C2.9,4 2.01,4.9 2.01,6 L2,18 C2,19.1 2.9,20 4,20 L20,20 C21.1,20 22,19.1 22,18 L22,6 C22,4.9 21.1,4 20,4 Z M20,8 L12,13 L4,8 L4,6 L12,11 L20,6 L20,8 Z" id="Shape" fill="#000000" fill-rule="nonzero"></path> </g> </svg> </a> </li> <li> <a class="social-media-sharer" href="https://twitter.com/intent/tweet/?text=Correction%3A%20TP53%20copy%20number%20expansion%20is%20associated%20with%20the%20evolution%20of%20increased%20body%20size%20and%20an%20enhanced%20DNA%20damage%20response%20in%20elephants&url=https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_blank" rel="noopener noreferrer" aria-label="Tweet a link to this page"> <svg width="24px" height="24px" viewBox="0 0 24 24" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g id="x-24-articles" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <rect id="Rectangle" x="0" y="0" width="24" height="24"></rect> <path d="M13.6604555,11.4785798 L20.954365,3 L19.225942,3 L12.8926412,10.3618317 L7.83425247,3 L2,3 L9.64927632,14.1323934 L2,23.023486 L3.72852106,23.023486 L10.4166498,15.2491415 L15.7586789,23.023486 L21.5929313,23.023486 L13.660031,11.4785798 L13.6604555,11.4785798 Z M11.293009,14.2304723 L10.5179779,13.1219369 L4.35133136,4.30120576 L7.00623887,4.30120576 L11.9827944,11.4198173 L12.7578255,12.5283527 L19.2267583,21.7814574 L16.5718508,21.7814574 L11.293009,14.2308968 L11.293009,14.2304723 Z" id="Shape" fill="#212121" fill-rule="nonzero"></path> </g> </svg> </a> </li> <li> <a class="social-media-sharer" href="https://facebook.com/sharer/sharer.php?u=https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_blank" rel="noopener noreferrer" aria-label="Share on Facebook"> <svg width="24px" height="24px" viewBox="0 0 24 24" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g id="facebook" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g> <rect id="clear-button-bg" x="0" y="0" width="24" height="24"></rect> <path d="M11.8969072,2 C6.43099227,2 2,6.41067993 2,11.8515383 C2,16.7687258 5.61915593,20.844338 10.3505155,21.5833958 L10.3505155,14.6992486 L7.83762887,14.6992486 L7.83762887,11.8515383 L10.3505155,11.8515383 L10.3505155,9.68112126 C10.3505155,7.21207948 11.8280541,5.84825714 14.0887242,5.84825714 C15.1715271,5.84825714 16.3041237,6.04067 16.3041237,6.04067 L16.3041237,8.465072 L15.0561469,8.465072 C13.8267075,8.465072 13.443299,9.22446783 13.443299,10.0035475 L13.443299,11.8515383 L16.1881443,11.8515383 L15.7493557,14.6992486 L13.443299,14.6992486 L13.443299,21.5833958 C18.1746585,20.844338 21.7938144,16.7687258 21.7938144,11.8515383 C21.7938144,6.41067993 17.3628222,2 11.8969072,2 Z" id="Fill-1" fill="#212121" fill-rule="nonzero"></path> </g> </g> </svg> </a> </li> <li> <a class="social-media-sharer" href="https://www.linkedin.com/shareArticle?title=Correction%3A%20TP53%20copy%20number%20expansion%20is%20associated%20with%20the%20evolution%20of%20increased%20body%20size%20and%20an%20enhanced%20DNA%20damage%20response%20in%20elephants&url=https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_self" aria-label="Share this page to LinkedIn (opens up email program, if configured on this system)"> <svg width="24px" height="24px" viewBox="0 0 24 24" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g id="linkedin" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g> <rect id="Rectangle" x="0" y="0" width="24" height="24"></rect> <path d="M18.9751954,18.9751435 L16.0232549,18.9751435 L16.0232549,14.3522816 C16.0232549,13.2499163 16.0035753,11.8308324 14.4879383,11.8308324 C12.9504693,11.8308324 12.7152366,13.0319032 12.7152366,14.2720257 L12.7152366,18.974836 L9.76329605,18.974836 L9.76329605,9.46835755 L12.5971589,9.46835755 L12.5971589,10.7675189 L12.6368256,10.7675189 C13.2146663,9.77952684 14.2890899,9.18943873 15.4328668,9.23189481 C18.4247815,9.23189481 18.9764254,11.1998552 18.9764254,13.7600486 L18.9751954,18.9751435 Z M6.43252317,8.16888879 C5.48643292,8.16905854 4.71933758,7.40223852 4.7191677,6.45614827 C4.71899794,5.51005802 5.48581795,4.74296266 6.4319082,4.74279278 C7.37799845,4.74262301 8.14509382,5.50944301 8.14526371,6.45553326 C8.14534522,6.90986184 7.96494211,7.34561469 7.64374096,7.66693118 C7.32253981,7.98824766 6.88685175,8.16880719 6.43252317,8.16888879 M7.90849343,18.9751435 L4.95347798,18.9751435 L4.95347798,9.46835755 L7.90849343,9.46835755 L7.90849343,18.9751435 Z M20.4468607,2.00148552 L3.47012787,2.00148552 C2.66777241,1.99243094 2.00979231,2.63513479 2,3.43748159 L2,20.4846305 C2.00945705,21.2873639 2.6673842,21.9307041 3.47012787,21.9223954 L20.4468607,21.9223954 C21.2511925,21.9322515 21.9116962,21.2889485 21.922831,20.4846305 L21.922831,3.43625161 C21.9113617,2.63231978 21.2508045,1.98965267 20.4468607,2" id="Path_2520" fill="#212121" fill-rule="nonzero"></path> </g> </g> </svg> </a> </li> <li> <a class="social-media-sharer" href="https://reddit.com/submit/?title=Correction%3A%20TP53%20copy%20number%20expansion%20is%20associated%20with%20the%20evolution%20of%20increased%20body%20size%20and%20an%20enhanced%20DNA%20damage%20response%20in%20elephants&url=https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_blank" rel="noopener noreferrer" aria-label="Share this page on Reddit"> <svg width="24px" height="24px" viewBox="0 0 24 24" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g id="reddit" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g> <rect id="Rectangle" x="0" y="0" width="24" height="24"></rect> <path d="M11.9872095,1.051163 C18.0270212,1.051163 22.923256,5.94739779 22.923256,11.9872095 C22.923256,18.0270212 18.0270212,22.923256 11.9872095,22.923256 C5.94739779,22.923256 1.051163,18.0270212 1.051163,11.9872095 C1.051163,5.94739779 5.94739779,1.051163 11.9872095,1.051163 Z M16.5534886,5.37441881 C16.1058142,5.37441881 15.7220932,5.63023277 15.5430235,6.0139537 L12.895349,5.451163 C12.8186049,5.4383723 12.7418607,5.451163 12.6779072,5.48953509 C12.6139537,5.52790719 12.5755816,5.59186067 12.5500002,5.66860486 L11.7441863,9.48023277 C10.0430235,9.53139556 8.52093044,10.0302328 7.42093044,10.8360467 C7.13953509,10.5674421 6.74302347,10.3883723 6.32093044,10.3883723 C5.4383723,10.3883723 4.72209323,11.1046514 4.72209323,11.9872095 C4.72209323,12.6395351 5.10581416,13.1895351 5.66860486,13.445349 C5.64302347,13.5988374 5.63023277,13.7651165 5.63023277,13.9313956 C5.63023277,16.3872095 8.48255835,18.3697677 12.0127909,18.3697677 C15.5430235,18.3697677 18.395349,16.3872095 18.395349,13.9313956 C18.395349,13.7651165 18.3825583,13.6116281 18.356977,13.4581397 C18.8813956,13.2023258 19.2779072,12.6395351 19.2779072,11.9872095 C19.2779072,11.1046514 18.5616281,10.3883723 17.67907,10.3883723 C17.2441863,10.3883723 16.8604653,10.5546514 16.57907,10.8360467 C15.4918607,10.0558142 13.9825583,9.54418626 12.3197677,9.48023277 L13.0488374,6.06511649 L15.4151165,6.5639537 C15.4406979,7.16511649 15.9395351,7.651163 16.5534886,7.651163 C17.1802328,7.651163 17.6918607,7.13953509 17.6918607,6.51279091 C17.6918607,5.88604672 17.1802328,5.37441881 16.5534886,5.37441881 Z M9.72325602,15.7093025 C10.2093025,16.195349 11.2581397,16.3744188 12.0127909,16.3744188 C12.7674421,16.3744188 13.8034886,16.195349 14.3023258,15.7093025 C14.4174421,15.5941863 14.6093025,15.5941863 14.7244188,15.7093025 C14.8139537,15.8372095 14.8139537,16.0162793 14.6988374,16.1313956 C13.9186049,16.9116281 12.4348839,16.9627909 12.0000002,16.9627909 C11.5651165,16.9627909 10.0686049,16.8988374 9.301163,16.1313956 C9.18604672,16.0162793 9.18604672,15.8244188 9.301163,15.7093025 C9.41627928,15.5941863 9.60813974,15.5941863 9.72325602,15.7093025 Z M9.48023277,11.9872095 C10.1069769,11.9872095 10.6186049,12.4988374 10.6186049,13.1255816 C10.6186049,13.7523258 10.1069769,14.2639537 9.48023277,14.2639537 C8.85348858,14.2639537 8.34186067,13.7523258 8.34186067,13.1255816 C8.34186067,12.4988374 8.85348858,11.9872095 9.48023277,11.9872095 Z M14.4941863,11.9872095 C15.1209304,11.9872095 15.6325583,12.4988374 15.6325583,13.1255816 C15.6325583,13.7523258 15.1209304,14.2639537 14.4941863,14.2639537 C13.8674421,14.2639537 13.3558142,13.7523258 13.3558142,13.1255816 C13.3558142,12.4988374 13.8674421,11.9872095 14.4941863,11.9872095 Z" id="Combined-Shape" fill="#212121" fill-rule="nonzero"></path> </g> </g> </svg> </a> </li> <li> <a class="social-media-sharer" href="https://toot.kytta.dev/?text=Correction%3A%20TP53%20copy%20number%20expansion%20is%20associated%20with%20the%20evolution%20of%20increased%20body%20size%20and%20an%20enhanced%20DNA%20damage%20response%20in%20elephants%20https%3A%2F%2Fdoi.org%2F10.7554%2FeLife.24307" target="_blank" rel="noopener noreferrer" aria-label="Share this page on Mastodon"> <svg width="24px" height="24px"> <g id="mastodon" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g> <rect id="Rectangle" x="0" y="0" width="24" height="24"></rect> <path d='M11.5412949,0 C14.6936837,0.0250851513 17.7279692,0.357269448 19.4950021,1.1471931 C19.4950021,1.1471931 22.9995752,2.67324958 22.9995752,7.87958222 L23,8.27840764 C22.9948717,9.32900538 22.9399626,12.2394095 22.5108214,14.3877566 C22.1727192,16.0807457 19.4826471,17.9335557 16.3930961,18.2926354 C14.7820287,18.4797396 13.1958041,18.6517151 11.5043627,18.5762011 C8.73816776,18.4528442 6.55544838,17.9335557 6.55544838,17.9335557 C6.55544838,18.1956567 6.57205459,18.4452152 6.605267,18.6786105 C6.96489093,21.335697 9.312211,21.4948713 11.5357152,21.5690923 C13.7799439,21.6438306 15.7782681,21.0305374 15.7782681,21.0305374 L15.8704657,23.0052819 C15.8704657,23.0052819 14.3007146,23.8257215 11.5043627,23.9766203 C9.96237703,24.0591169 8.04774824,23.9388633 5.8177344,23.3643616 C0.981210876,22.1183796 0.149439349,17.1004442 0.022169409,12.0089343 C-0.0166226796,10.4972307 0.00729025582,9.07177343 0.00729025582,7.87958222 C0.00729025582,2.67324958 3.51199627,1.1471931 3.51199627,1.1471931 C5.27916201,0.357269448 8.31145476,0.0250851513 11.4638436,0 L11.5412949,0 Z M15.8599153,5 C14.461897,5 13.4033065,5.46697151 12.7035195,6.40103745 L12.0229667,7.39238391 L11.3425554,6.40103745 C10.642627,5.46697151 9.58403654,5 8.18615964,5 C6.97793807,5 6.00462882,5.36912752 5.26142334,6.08919046 C4.54070495,6.8092534 4.18190148,7.78253068 4.18190148,9.00730143 L4.18190148,15 L6.91358821,15 L6.91358821,9.1834452 C6.91358821,7.95732233 7.50716259,7.33498047 8.69445278,7.33498047 C10.0071899,7.33498047 10.6652556,8.0732355 10.6652556,9.5330285 L10.6652556,12.7167687 L13.3808194,12.7167687 L13.3808194,9.5330285 C13.3808194,8.0732355 14.0387436,7.33498047 15.3514807,7.33498047 C16.5387709,7.33498047 17.1323453,7.95732233 17.1323453,9.1834452 L17.1323453,15 L19.864032,15 L19.864032,9.00730143 C19.864032,7.78253068 19.5052285,6.8092534 18.7846516,6.08919046 C18.0413047,5.36912752 17.0679954,5 15.8599153,5 Z' id='Combined-Shape' fill='#212121' fill-rule='nonzero'></path> </g> </g> </svg> </a> </li> </ul> </div> </section> <section class="article-meta"> <div class="article-meta__container"> <section class="article-meta__group"> <h4 class="article-meta__group_title">Categories and tags</h4> <ul class="article-meta__link_list"> <li class="article-meta__link_list_item"> <a href="/articles/correction" class="article-meta__link">Correction</a></li> <li class="article-meta__link_list_item"> <a href="/subjects/cell-biology" class="article-meta__link">Cell Biology</a></li> <li class="article-meta__link_list_item"> <a href="/subjects/evolutionary-biology" class="article-meta__link">Evolutionary Biology</a></li> </ul> </section> </div> </section> </div> </div> </div> </div> <script type="application/ld+json"> { "@context": "https://schema.org", "@type": "ScholarlyArticle", "mainEntityOfPage": { "@type": "WebPage", "@id": "https://elifesciences.org/articles/24307" }, "headline": "Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants", "datePublished": "2016-12-20", "author": [ { "@type": "Person", "name": "Michael Sulak" }, { "@type": "Person", "name": "Lindsey Fong" }, { "@type": "Person", "name": "Katelyn Mika" }, { "@type": "Person", "name": "Sravanthi Chigurupati" }, { "@type": "Person", "name": "Lisa Yon" }, { "@type": "Person", "name": "Nigel P Mongan" }, { "@type": "Person", "name": "Richard D Emes" }, { "@type": "Person", "name": "Vincent J Lynch" } ], "publisher": { "@type": "Organization", "name": "eLife Sciences Publications, Ltd", "logo": { "@type": "ImageObject", "url": "https://elifesciences.org/assets/patterns/img/patterns/organisms/elife-logo-symbol@2x.ff81306e.png" } }, "about": [ "Cell Biology", "Evolutionary Biology" ], "isPartOf": { "@type": "Periodical", "name": "eLife", "issn": "2050-084X" } } </script> </main> <section class="email-cta"> <div class="email-cta__container"> <header class="email-cta__header"> <h2 class="email-cta__header_text">Be the first to read new articles from eLife</h2> </header> <a href="/content-alerts" class="button button--default email-cta__button">Sign up for email alerts</a> <div class="email-cta__privacy"> <a class="email-cta__privacy_link" href="/privacy">Privacy notice</a> </div> </div> </section> <div class="main-menu wrapper" id="mainMenu" data-behaviour="MainMenu" tabindex="0"> <div class="main-menu__title-container"> <div class="site-header__title clearfix" role="banner"> <div class="site-header__skip_to_content"> <a href="#maincontent" class="site-header__skip_to_content__link button button--default">Skip to Content</a> </div> <a href="/" class="site-header__logo_link"> <picture class="site-header__logo_link_image"> <source srcset="/assets/patterns/img/patterns/organisms/elife-logo-xs.fd623d00.svg" type="image/svg+xml"> <img src="/assets/patterns/img/patterns/organisms/elife-logo-xs@1x.f9b97bde.png" alt="eLife logo" class="site-header__logo_link"/> </picture> <span class="visuallyhidden" >eLife home page</span> </a> </div> </div> <nav class="main-menu__container" role="navigation"> <h3 class="list-heading">Menu</h3> <ul class="main-menu__list"> <li class="main-menu__list_item hidden-wide"> <a href="/" class="main-menu__list_link">Home</a> </li> <li class="main-menu__list_item hidden-wide"> <a href="/magazine" class="main-menu__list_link">Magazine</a> </li> <li class="main-menu__list_item hidden-wide"> <a href="/community" class="main-menu__list_link">Community</a> </li> <li class="main-menu__list_item hidden-wide"> <a href="/about" class="main-menu__list_link">About</a> </li> <li class="main-menu__list_item"> <a href="/subjects" class="main-menu__list_link">Research categories</a> </li> <li class="main-menu__list_item end-of-group"> <a href="/inside-elife" class="main-menu__list_link">Inside eLife</a> </li> <li class="main-menu__list_item hidden-wide"> <a href="/search" class="main-menu__list_link">Search</a> </li> <li class="main-menu__list_item hidden-wide end-of-group"> <a href="/content-alerts" class="main-menu__list_link">Subscribe to alerts</a> </li> <li class="main-menu__list_item hidden-wide"> <a href="https://elifesciences.org/submit-your-research" class="main-menu__list_link">Submit your research</a> </li> <li class="main-menu__list_item"> <a href="https://reviewer.elifesciences.org/author-guide/editorial-process" class="main-menu__list_link">Author guide</a> </li> <li class="main-menu__list_item"> <a href="https://reviewer.elifesciences.org/reviewer-guide/review-process" class="main-menu__list_link">Reviewer guide</a> </li> </ul> <a href="#siteHeader" class="to-top-link">Back to top</a> </nav> </div> <ol class="investor-logos" role="list" aria-label="eLife is funded by these organisations"> <li class="investor-logos__item" role="listitem"> <div class="investor-logos__container"> <picture class="investor-logos__picture"> <source srcset="/assets/images/investors/hhmi.9d0951a2.svg" type="image/svg+xml" > <source srcset="/assets/images/investors/hhmi@2x.39287b22.webp 2x, /assets/images/investors/hhmi@1x.7a33c14e.webp 1x" type="image/webp" > <source srcset="/assets/images/investors/hhmi@2x.1ad6ab6c.png 2x, /assets/images/investors/hhmi@1x.739f96c8.png 1x" type="image/png" > <img src="/assets/images/investors/hhmi@1x.739f96c8.png" alt="Howard Hughes Medical Institute" class="investor-logos__img" > </picture> </div> </li> <li class="investor-logos__item" role="listitem"> <div class="investor-logos__container"> <picture class="investor-logos__picture"> <source srcset="/assets/images/investors/wellcome.813f8634.svg" type="image/svg+xml" > <source srcset="/assets/images/investors/wellcome@2x.20f8e70c.webp 2x, /assets/images/investors/wellcome@1x.04660921.webp 1x" type="image/webp" > <source srcset="/assets/images/investors/wellcome@2x.04433270.png 2x, /assets/images/investors/wellcome@1x.b38198be.png 1x" type="image/png" > <img src="/assets/images/investors/wellcome@1x.b38198be.png" alt="Wellcome Trust" class="investor-logos__img" > </picture> </div> </li> <li class="investor-logos__item" role="listitem"> <div class="investor-logos__container"> <picture class="investor-logos__picture"> <source srcset="/assets/images/investors/max.a0546fd2.svg" type="image/svg+xml" > <source srcset="/assets/images/investors/max@2x.8503a434.webp 2x, /assets/images/investors/max@1x.893132ad.webp 1x" type="image/webp" > <source srcset="/assets/images/investors/max@2x.727ba110.png 2x, /assets/images/investors/max@1x.71f18cc3.png 1x" type="image/png" > <img src="/assets/images/investors/max@1x.71f18cc3.png" alt="Max-Planck-Gesellschaft" class="investor-logos__img" > </picture> </div> </li> <li class="investor-logos__item" role="listitem"> <div class="investor-logos__container"> <picture class="investor-logos__picture"> <source srcset="/assets/images/investors/kaw.db745e57.svg" type="image/svg+xml" > <source srcset="/assets/images/investors/kaw@2x.dfb04de2.webp 2x, /assets/images/investors/kaw@1x.aabae49d.webp 1x" type="image/webp" > <source srcset="/assets/images/investors/kaw@2x.ee42bf3a.png 2x, /assets/images/investors/kaw@1x.d11d4f95.png 1x" type="image/png" > <img src="/assets/images/investors/kaw@1x.d11d4f95.png" alt="Knut and Alice Wallenberg Foundation" class="investor-logos__img" > </picture> </div> </li> </ol> <footer class="site-footer"> <div class="site-footer__container"> <div class="grid-cell"> <nav class="footer-navigation"> <ul class="footer-navigation__list"> <li class="footer-navigation__list_item"> <a href="/about" class="footer-navigation__list_link">About</a> </li> <li class="footer-navigation__list_item"> <a href="/jobs" class="footer-navigation__list_link">Jobs</a> </li> <li class="footer-navigation__list_item"> <a href="/who-we-work-with" class="footer-navigation__list_link">Who we work with</a> </li> <li class="footer-navigation__list_item"> <a href="/alerts" class="footer-navigation__list_link">Alerts</a> </li> <li class="footer-navigation__list_item"> <a href="/contact" class="footer-navigation__list_link">Contact</a> </li> <li class="footer-navigation__list_item"> <a href="/terms" class="footer-navigation__list_link">Terms and conditions</a> </li> <li class="footer-navigation__list_item"> <a href="/privacy" class="footer-navigation__list_link">Privacy notice</a> </li> <li class="footer-navigation__list_item"> <a href="/inside-elife" class="footer-navigation__list_link">Inside eLife</a> </li> <li class="footer-navigation__list_item"> <a href="/archive/2025" class="footer-navigation__list_link">Monthly archive</a> </li> <li class="footer-navigation__list_item"> <a href="/for-the-press" class="footer-navigation__list_link">For the press</a> </li> <li class="footer-navigation__list_item"> <a href="/resources" class="footer-navigation__list_link">Resources</a> </li> <li class="footer-navigation__list_item"> <a href="http://developers.elifesciences.org" class="footer-navigation__list_link">XML and Data</a> </li> </ul> </nav> <div class="social-links" aria-label="Social media links for eLife Sciences"> <ul class="social-links__list"> <li class="social-links__list_item"> <a href="https://twitter.com/elife" class="social-links__list_link" aria-label="Twitter"> <svg width="28px" height="28px" viewBox="0 0 28 28" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g id="x-28-footer" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <rect id="Rectangle" x="0" y="0" width="28" height="28"></rect> <path d="M16.0929883,12.5202067 L24.2829833,3 L22.3422167,3 L15.230845,11.2662617 L9.55101333,3 L3,3 L11.58902,15.5000517 L3,25.48345 L4.94087667,25.48345 L12.4506683,16.7539967 L18.4489867,25.48345 L25,25.48345 L16.0925117,12.5202067 L16.0929883,12.5202067 Z M13.4346917,15.61018 L12.564445,14.3654567 L5.64020167,4.461064 L8.621275,4.461064 L14.20922,12.454225 L15.0794667,13.6989483 L22.3431333,24.0888333 L19.36206,24.0888333 L13.4346917,15.6106567 L13.4346917,15.61018 Z" id="Shape" fill="#212121" fill-rule="nonzero"></path> </g> </svg> </a> </li> <li class="social-links__list_item"> <a href="https://www.facebook.com/elifesciences" class="social-links__list_link" aria-label="Facebook"> <svg width="28" height="28"> <path d="M26,14 C26,7.37257812 20.6274219,2 14,2 C7.37257813,2 2,7.37257812 2,14 C2,19.9895469 6.38822656,24.9539844 12.125,25.8542187 L12.125,17.46875 L9.078125,17.46875 L9.078125,14 L12.125,14 L12.125,11.35625 C12.125,8.34875 13.9165156,6.6875 16.6575781,6.6875 C17.9704766,6.6875 19.34375,6.921875 19.34375,6.921875 L19.34375,9.875 L17.8305781,9.875 C16.3398828,9.875 15.875,10.8000078 15.875,11.7489922 L15.875,14 L19.203125,14 L18.6710938,17.46875 L15.875,17.46875 L15.875,25.8542187 C21.6117734,24.9539844 26,19.9895469 26,14" id="Fill-1" fill="#0A0B09"></path> </svg> </a> </li> <li class="social-links__list_item"> <a href="https://www.instagram.com/elifesciences/" class="social-links__list_link" aria-label="Instagram"> <svg width="28" height="28"> <path d="M13.9999762,4.16220594 C17.2041298,4.16220594 17.5836306,4.17440025 18.8489821,4.23213276 C20.0189703,4.28553056 20.6543612,4.48102079 21.0772565,4.64531072 C21.6373379,4.86299845 22.0371308,5.12308049 22.4570251,5.54297487 C22.8769195,5.96286924 23.1370016,6.36266203 23.3546416,6.92274348 C23.5189792,7.3456388 23.7144694,7.98102972 23.7678672,9.15097025 C23.8255997,10.4163695 23.8377941,10.7958701 23.8377941,14.0000238 C23.8377941,17.2041775 23.8255997,17.5836782 23.7678672,18.8490297 C23.7144694,20.0190179 23.5189792,20.6544088 23.3546416,21.0773041 C23.1370016,21.6373856 22.8769195,22.0371784 22.4570251,22.4570727 C22.0371308,22.8769671 21.6373379,23.1370492 21.0772565,23.3546892 C20.6543612,23.5190268 20.0189703,23.7145171 18.8489821,23.7679149 C17.5838211,23.8256473 17.2043204,23.8378417 13.9999762,23.8378417 C10.795632,23.8378417 10.4161313,23.8256473 9.15097025,23.7679149 C7.9809821,23.7145171 7.34559117,23.5190268 6.92274348,23.3546892 C6.3626144,23.1370492 5.9628216,22.8769671 5.54292723,22.4570727 C5.12303286,22.0371784 4.86295081,21.6373856 4.64531072,21.0773041 C4.48097317,20.6544088 4.28548292,20.0190179 4.23208512,18.8490774 C4.17435262,17.5836782 4.1621583,17.2041775 4.1621583,14.0000238 C4.1621583,10.7958701 4.17435262,10.4163695 4.23208512,9.15101788 C4.28548292,7.98102972 4.48097317,7.3456388 4.64531072,6.92274348 C4.86295081,6.36266203 5.12303286,5.96286924 5.54292723,5.54297487 C5.9628216,5.12308049 6.3626144,4.86299845 6.92274348,4.64531072 C7.34559117,4.48102079 7.9809821,4.28553056 9.15092262,4.23213276 C10.4163218,4.17440025 10.7958225,4.16220594 13.9999762,4.16220594 M13.9999762,2 C10.740948,2 10.3323429,2.01381388 9.05241535,2.07221326 C7.77510763,2.13051737 6.90283244,2.33334326 6.13949638,2.63000828 C5.35039031,2.93667645 4.68117918,3.34699637 4.01406396,4.01411159 C3.34694874,4.68122682 2.93662882,5.35043793 2.62996064,6.13954402 C2.33329562,6.90288008 2.13046973,7.77515526 2.07216562,9.05246298 C2.01376625,10.3323429 2,10.7409957 2,14.0000238 C2,17.259052 2.01376625,17.6677047 2.07216562,18.9475846 C2.13046973,20.2248924 2.33329562,21.0971676 2.62996064,21.8605036 C2.93662882,22.649562 3.34694874,23.3188208 4.01406396,23.985936 C4.68117918,24.6530513 5.35039031,25.0633712 6.13949638,25.3700394 C6.90283244,25.6667044 7.77510763,25.8695303 9.05241535,25.9278343 C10.3323429,25.9862338 10.740948,26 13.9999762,26 C17.2590043,26 17.667657,25.9862338 18.947537,25.9278343 C20.2248448,25.8695303 21.09712,25.6667044 21.860456,25.3700394 C22.649562,25.0633712 23.3187732,24.6530513 23.9858884,23.985936 C24.6530037,23.3188208 25.0633236,22.6496097 25.3699918,21.8605036 C25.6666568,21.0971676 25.8694827,20.2248924 25.9277867,18.9475846 C25.9861861,17.6677047 26,17.259052 26,14.0000238 C26,10.7409957 25.9861861,10.3323429 25.9277867,9.05246298 C25.8694827,7.77515526 25.6666568,6.90288008 25.3699918,6.13954402 C25.0633236,5.35043793 24.6530037,4.68122682 23.9858884,4.01411159 C23.3187732,3.34699637 22.649562,2.93667645 21.860456,2.63000828 C21.09712,2.33334326 20.2248448,2.13051737 18.947537,2.07221326 C17.667657,2.01381388 17.2590043,2 13.9999762,2 Z M13.9999762,7.8378417 C10.5967121,7.8378417 7.83779407,10.5967597 7.83779407,14.0000238 C7.83779407,17.4032879 10.5967121,20.162206 13.9999762,20.162206 C17.4032403,20.162206 20.1621583,17.4032879 20.1621583,14.0000238 C20.1621583,10.5967597 17.4032403,7.8378417 13.9999762,7.8378417 Z M13.9999762,18.0000477 C11.7908507,18.0000477 9.99995236,16.2091493 9.99995236,14.0000238 C9.99995236,11.7908983 11.7908507,10 13.9999762,10 C16.2091017,10 18,11.7908983 18,14.0000238 C18,16.2091493 16.2091017,18.0000477 13.9999762,18.0000477 Z M21.8455942,7.59438394 C21.8455942,8.38968246 21.2009145,9.03440967 20.405616,9.03440967 C19.6103175,9.03440967 18.9655903,8.38968246 18.9655903,7.59438394 C18.9655903,6.79908542 19.6103175,6.15440585 20.405616,6.15440585 C21.2009145,6.15440585 21.8455942,6.79908542 21.8455942,7.59438394 Z" id="Shape" fill="#212121" fill-rule="nonzero"></path> </svg> </a> </li> <li class="social-links__list_item"> <a href="https://www.youtube.com/channel/UCNEHLtAc_JPI84xW8V4XWyw" class="social-links__list_link" aria-label="YouTube"> <svg width="28" height="28"> <path d="M14.3394034,5.00081974 C15.0650046,5.00416663 16.8547629,5.01866982 18.7408249,5.08151696 L19.3085648,5.10185861 L19.3085648,5.10185861 L19.8762758,5.12532402 C21.6678517,5.20481265 23.3716441,5.33464406 24.1578396,5.54670204 C25.2765782,5.84762249 26.157476,6.73428158 26.456476,7.86025886 C26.9532448,9.72604587 26.995825,13.4452634 26.9994747,14.0691357 L26.9994747,14.2486746 C26.995825,14.8725277 26.9532448,18.5916449 26.456476,20.457702 C26.157476,21.5835316 25.2765782,22.4701907 24.1578396,22.7712589 C23.3302654,22.9944175 21.4859633,23.126491 19.5927869,23.2046569 L19.0243355,23.2265266 C16.9417355,23.3010584 14.9171078,23.3148606 14.2386654,23.3174166 L13.7609683,23.3174166 C12.4040836,23.3123047 5.66245741,23.2622078 3.84179414,22.7712589 C2.72320323,22.4701907 1.84215778,21.5835316 1.54315778,20.457702 C1.06191297,18.6499592 1.00691357,15.1031629 1.00062792,14.316078 L1.00062792,14.0017303 C1.00691357,13.2146223 1.06191297,9.66774002 1.54315778,7.86025886 C1.84215778,6.73428158 2.72320323,5.84762249 3.84179414,5.54670204 C5.6210787,5.06678135 12.1001879,5.00801555 13.6602303,5.00081974 Z M11.1612194,10.2011473 L11.1612194,17.7986829 L17.8387126,14.0000603 L11.1612194,10.2011473 Z" id="Combined-Shape" fill="#222321"></path> </svg> </a> </li> <li class="social-links__list_item"> <a href="https://www.linkedin.com/company/elife-sciences-publications-ltd" class="social-links__list_link" aria-label="LinkedIn"> <svg width="28" height="28"> <path d="M22.3830154,22.3830154 L18.8384,22.3830154 L18.8384,16.832 C18.8384,15.5083077 18.8147692,13.8043077 16.9948308,13.8043077 C15.1486769,13.8043077 14.8662154,15.2465231 14.8662154,16.7356308 L14.8662154,22.3826462 L11.3216,22.3826462 L11.3216,10.9675077 L14.7244308,10.9675077 L14.7244308,12.5275077 L14.7720615,12.5275077 C15.465918,11.3411519 16.7560586,10.632589 18.1294769,10.6835692 C21.7220923,10.6835692 22.3844923,13.0466462 22.3844923,16.1208615 L22.3830154,22.3830154 Z M7.32209231,9.4071385 C6.1860511,9.40734236 5.26494244,8.48656431 5.26473849,7.3505231 C5.26453461,6.21448189 6.18531266,5.29337322 7.32135387,5.29316926 C8.45739508,5.29296537 9.37850375,6.21374341 9.37870773,7.34978462 C9.37880563,7.89533086 9.16218215,8.41857185 8.77649194,8.80440054 C8.39080174,9.19022923 7.86763855,9.40704054 7.32209231,9.4071385 M9.0944,22.3830154 L5.54609231,22.3830154 L5.54609231,10.9675077 L9.0944,10.9675077 L9.0944,22.3830154 Z M24.1501538,2.00147692 L3.76492308,2.00147692 C2.80147497,1.99060441 2.01138912,2.76234691 1.99963077,3.72578462 L1.99963077,24.1955692 C2.01098655,25.1594712 2.80100881,25.9319778 3.76492308,25.9218636 L24.1501538,25.9218636 C25.115975,25.9338359 25.9090911,25.1613738 25.9224615,24.1955692 L25.9224615,3.72430769 C25.9086895,2.75896671 25.1155091,1.98726833 24.1501538,1.9998447" id="Path_2520" fill="#212121" fill-rule="nonzero"></path> </svg> </a> </li> <li class="social-links__list_item"> <a rel='me' href='https://fediscience.org/@eLife' class='social-links__list_link' aria-label='Mastodon'> <svg width="28px" height="28px"> <g id="Artboard" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g id="Group-7" transform="translate(3.000000, 2.000000)" fill="#212121" fill-rule="nonzero"> <g id="mastodon-24px-black"> <path d="M11.5412949,0 C14.6936837,0.0250851513 17.7279692,0.357269448 19.4950021,1.1471931 C19.4950021,1.1471931 22.9995752,2.67324958 22.9995752,7.87958222 L23,8.27840764 C22.9948717,9.32900538 22.9399626,12.2394095 22.5108214,14.3877566 C22.1727192,16.0807457 19.4826471,17.9335557 16.3930961,18.2926354 C14.7820287,18.4797396 13.1958041,18.6517151 11.5043627,18.5762011 C8.73816776,18.4528442 6.55544838,17.9335557 6.55544838,17.9335557 C6.55544838,18.1956567 6.57205459,18.4452152 6.605267,18.6786105 C6.96489093,21.335697 9.312211,21.4948713 11.5357152,21.5690923 C13.7799439,21.6438306 15.7782681,21.0305374 15.7782681,21.0305374 L15.8704657,23.0052819 C15.8704657,23.0052819 14.3007146,23.8257215 11.5043627,23.9766203 C9.96237703,24.0591169 8.04774824,23.9388633 5.8177344,23.3643616 C0.981210876,22.1183796 0.149439349,17.1004442 0.022169409,12.0089343 C-0.0166226796,10.4972307 0.00729025582,9.07177343 0.00729025582,7.87958222 C0.00729025582,2.67324958 3.51199627,1.1471931 3.51199627,1.1471931 C5.27916201,0.357269448 8.31145476,0.0250851513 11.4638436,0 L11.5412949,0 Z M15.8599153,5 C14.461897,5 13.4033065,5.46697151 12.7035195,6.40103745 L12.0229667,7.39238391 L11.3425554,6.40103745 C10.642627,5.46697151 9.58403654,5 8.18615964,5 C6.97793807,5 6.00462882,5.36912752 5.26142334,6.08919046 C4.54070495,6.8092534 4.18190148,7.78253068 4.18190148,9.00730143 L4.18190148,15 L6.91358821,15 L6.91358821,9.1834452 C6.91358821,7.95732233 7.50716259,7.33498047 8.69445278,7.33498047 C10.0071899,7.33498047 10.6652556,8.0732355 10.6652556,9.5330285 L10.6652556,12.7167687 L13.3808194,12.7167687 L13.3808194,9.5330285 C13.3808194,8.0732355 14.0387436,7.33498047 15.3514807,7.33498047 C16.5387709,7.33498047 17.1323453,7.95732233 17.1323453,9.1834452 L17.1323453,15 L19.864032,15 L19.864032,9.00730143 C19.864032,7.78253068 19.5052285,6.8092534 18.7846516,6.08919046 C18.0413047,5.36912752 17.0679954,5 15.8599153,5 Z" id="Combined-Shape"></path> </g> </g> </g> </svg> </a> </li> </ul> </div> <div class="github-link-wrapper"> <a href="https://github.com/elifesciences" class="github-link"> <svg width="20" height="20"> <g id="Page-1" stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g id="github-logo-svg" fill="#000000"> <path d="M9.99907916,1.72084569e-15 C4.47773105,1.72084569e-15 2.22044605e-16,4.5904205 2.22044605e-16,10.2533868 C2.22044605e-16,14.7833822 2.86503576,18.6260419 6.83876117,19.9818304 C7.33908346,20.0762447 7.5214095,19.7596422 7.5214095,19.4877292 C7.5214095,19.2441405 7.512815,18.5996059 7.50790386,17.7442129 C4.72635747,18.3635703 4.13947635,16.3695415 4.13947635,16.3695415 C3.68458209,15.1849574 3.02894503,14.8696139 3.02894503,14.8696139 C2.12099819,14.2338913 3.09770097,14.2464799 3.09770097,14.2464799 C4.10141502,14.3188641 4.62936247,15.30329 4.62936247,15.30329 C5.52134811,16.869937 6.97013414,16.417378 7.53982627,16.1549064 C7.63068234,15.4927479 7.88913104,15.0408184 8.17459099,14.784641 C5.95414224,14.525946 3.6195095,13.6460053 3.6195095,9.7171139 C3.6195095,8.59799041 4.00933116,7.68217225 4.64900703,6.96588286 C4.54587311,6.7065584 4.20270727,5.66359573 4.74722981,4.25241751 C4.74722981,4.25241751 5.5864207,3.97672792 7.4968538,5.30356275 C8.29430001,5.07570971 9.15006599,4.96241262 10.0003069,4.95800662 C10.849934,4.96241262 11.7050861,5.07570971 12.5037601,5.30356275 C14.4129654,3.97672792 15.2509285,4.25241751 15.2509285,4.25241751 C15.7966788,5.66359573 15.453513,6.7065584 15.350993,6.96588286 C15.9918966,7.68217225 16.3786488,8.59799041 16.3786488,9.7171139 C16.3786488,13.6560761 14.0403327,14.5227989 11.8131312,14.7764585 C12.1716443,15.0930609 12.4914822,15.7187126 12.4914822,16.6748142 C12.4914822,18.045709 12.4792044,19.1516145 12.4792044,19.4877292 C12.4792044,19.7621599 12.6596888,20.0812801 13.1667639,19.981201 C17.1374198,18.6222653 20,14.7821233 20,10.2533868 C20,4.5904205 15.5222689,1.72084569e-15 9.99907916,1.72084569e-15" id="Fill-51"></path> </g> </g> </svg> <div class="github-link--text">Find us on GitHub</div> </a> </div> <div class="carbon-neutral-wrapper"> <a href="https://positiveplanet.uk/company-dashboards/elife-sciences/" class="carbon-neutral-link"> <img src="/assets/patterns/img/patterns/molecules/carbon-neutral.706efe6d.svg" alt="Positive Planet - Certified Carbon Neutral"> </a> </div> </div> <div class="grid-cell"> <div class="site-smallprint"> <small>eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science.</small> <small>eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware, USA, with company number 5030732, and is registered in the UK with company number FC030576 and branch number BR015634 at the address:</small> <address> eLife Sciences Publications, Ltd<br> 95 Regent Street<br> Cambridge CB2 1AW<br> UK </address> </div> <div class="site-smallprint"> <small>© <time>2025</time> eLife Sciences Publications Ltd. Subject to a <a href="https://creativecommons.org/licenses/by/4.0/" rel="license" class="site-smallprint__copyright_link">Creative Commons Attribution license</a>, except where otherwise noted. ISSN: 2050-084X</small> </div> </div> </div> </footer> </div> </div> <script> window.elifeConfig = window.elifeConfig || {}; window.elifeConfig.scriptPaths = [ '/assets/patterns/js/main.c88b96f1.js' ]; window.elifeConfig.hypothesis = { usernameUrl: 'https://elifesciences.org/profiles/', services: [{ apiUrl: 'https://hypothes.is/api/', authority: 'elifesciences.org', grantToken: null, onLoginRequest: function () { window.location.assign('/log-in'); }, onSignupRequest: function () { window.location.assign('/log-in'); } }] }; window.elifeConfig.domain = 'elifesciences.org'; (function (window) { 'use strict'; try { var scriptPaths, $body; if ( !!window.localStorage && !!(window.document.createElement('div')).dataset && typeof window.document.querySelector === 'function' && typeof window.addEventListener === 'function' ) { scriptPaths = window.elifeConfig.scriptPaths; if (Array.isArray(scriptPaths) && scriptPaths.length) { $body = window.document.querySelector('body'); scriptPaths.forEach(function (scriptPath) { var $script = window.document.createElement('script'); $script.src = scriptPath; $body.appendChild($script); }); } } } catch (e) { window.console.error('JavaScript loading failed with the error: "' + e + '". Additionally, RUM logging failed.'); } }(window)); </script> <link href="/assets/patterns/css/all.49307731.css" rel="stylesheet"> </body> </html>